-- dump date 20140620_041741 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266117000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 266117000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266117000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000004 Walker A motif; other site 266117000005 ATP binding site [chemical binding]; other site 266117000006 Walker B motif; other site 266117000007 arginine finger; other site 266117000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266117000009 DnaA box-binding interface [nucleotide binding]; other site 266117000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 266117000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266117000012 putative DNA binding surface [nucleotide binding]; other site 266117000013 dimer interface [polypeptide binding]; other site 266117000014 beta-clamp/clamp loader binding surface; other site 266117000015 beta-clamp/translesion DNA polymerase binding surface; other site 266117000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117000017 RNA binding surface [nucleotide binding]; other site 266117000018 recombination protein F; Reviewed; Region: recF; PRK00064 266117000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117000020 Walker A/P-loop; other site 266117000021 ATP binding site [chemical binding]; other site 266117000022 Q-loop/lid; other site 266117000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117000024 ABC transporter signature motif; other site 266117000025 Walker B; other site 266117000026 D-loop; other site 266117000027 H-loop/switch region; other site 266117000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 266117000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000030 ATP binding site [chemical binding]; other site 266117000031 Mg2+ binding site [ion binding]; other site 266117000032 G-X-G motif; other site 266117000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266117000034 anchoring element; other site 266117000035 dimer interface [polypeptide binding]; other site 266117000036 ATP binding site [chemical binding]; other site 266117000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266117000038 active site 266117000039 putative metal-binding site [ion binding]; other site 266117000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266117000041 DNA gyrase subunit A; Validated; Region: PRK05560 266117000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266117000043 CAP-like domain; other site 266117000044 active site 266117000045 primary dimer interface [polypeptide binding]; other site 266117000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266117000052 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266117000053 LabA_like proteins; Region: LabA_like; cd06167 266117000054 putative metal binding site [ion binding]; other site 266117000055 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 266117000056 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 266117000057 L-aspartate oxidase; Provisional; Region: PRK06175 266117000058 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266117000059 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 266117000060 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266117000061 catalytic loop [active] 266117000062 iron binding site [ion binding]; other site 266117000063 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 266117000064 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266117000065 nudix motif; other site 266117000066 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 266117000067 Flavoprotein; Region: Flavoprotein; pfam02441 266117000068 RDD family; Region: RDD; pfam06271 266117000069 classical (c) SDRs; Region: SDR_c; cd05233 266117000070 NAD(P) binding site [chemical binding]; other site 266117000071 active site 266117000072 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266117000073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117000074 Beta-Casp domain; Region: Beta-Casp; smart01027 266117000075 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266117000076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266117000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117000078 active site 266117000079 ATP binding site [chemical binding]; other site 266117000080 substrate binding site [chemical binding]; other site 266117000081 activation loop (A-loop); other site 266117000082 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266117000083 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266117000084 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266117000085 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266117000086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117000087 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 266117000088 Protein phosphatase 2C; Region: PP2C; pfam00481 266117000089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266117000090 active site 266117000091 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266117000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266117000093 phosphopeptide binding site; other site 266117000094 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 266117000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266117000096 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266117000097 phosphopeptide binding site; other site 266117000098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117000099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266117000100 active site 266117000101 ATP binding site [chemical binding]; other site 266117000102 substrate binding site [chemical binding]; other site 266117000103 activation loop (A-loop); other site 266117000104 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266117000105 AsnC family; Region: AsnC_trans_reg; pfam01037 266117000106 carboxylate-amine ligase; Provisional; Region: PRK13517 266117000107 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266117000108 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266117000109 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266117000110 catalytic residues [active] 266117000111 Methylamine utilisation protein MauE; Region: MauE; pfam07291 266117000112 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 266117000113 TAP-like protein; Region: Abhydrolase_4; pfam08386 266117000114 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266117000115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000116 ATP binding site [chemical binding]; other site 266117000117 Mg2+ binding site [ion binding]; other site 266117000118 G-X-G motif; other site 266117000119 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 266117000120 ATP binding site [chemical binding]; other site 266117000121 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 266117000122 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266117000123 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266117000124 carboxyltransferase (CT) interaction site; other site 266117000125 biotinylation site [posttranslational modification]; other site 266117000126 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266117000127 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117000128 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117000129 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266117000130 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 266117000131 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 266117000132 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 266117000133 hypothetical protein; Validated; Region: PRK08116 266117000134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000135 Walker A motif; other site 266117000136 ATP binding site [chemical binding]; other site 266117000137 Walker B motif; other site 266117000138 arginine finger; other site 266117000139 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 266117000140 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 266117000141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117000142 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266117000143 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266117000144 dimer interface [polypeptide binding]; other site 266117000145 ssDNA binding site [nucleotide binding]; other site 266117000146 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266117000147 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266117000148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266117000149 DNA binding residues [nucleotide binding] 266117000150 dimer interface [polypeptide binding]; other site 266117000151 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 266117000152 putative active site [active] 266117000153 transaldolase; Provisional; Region: PRK03903 266117000154 catalytic residue [active] 266117000155 transketolase; Reviewed; Region: PRK05899 266117000156 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266117000157 TPP-binding site [chemical binding]; other site 266117000158 dimer interface [polypeptide binding]; other site 266117000159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266117000160 PYR/PP interface [polypeptide binding]; other site 266117000161 dimer interface [polypeptide binding]; other site 266117000162 TPP binding site [chemical binding]; other site 266117000163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117000164 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 266117000165 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266117000166 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266117000167 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266117000168 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266117000169 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 266117000170 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266117000171 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266117000172 putative active site [active] 266117000173 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117000174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117000175 NAD(P) binding site [chemical binding]; other site 266117000176 active site 266117000177 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266117000178 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 266117000179 putative NAD(P) binding site [chemical binding]; other site 266117000180 putative substrate binding site [chemical binding]; other site 266117000181 catalytic Zn binding site [ion binding]; other site 266117000182 structural Zn binding site [ion binding]; other site 266117000183 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266117000184 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266117000185 oligomer interface [polypeptide binding]; other site 266117000186 metal binding site [ion binding]; metal-binding site 266117000187 metal binding site [ion binding]; metal-binding site 266117000188 putative Cl binding site [ion binding]; other site 266117000189 basic sphincter; other site 266117000190 hydrophobic gate; other site 266117000191 periplasmic entrance; other site 266117000192 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 266117000193 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117000194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117000195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117000196 Walker A/P-loop; other site 266117000197 ATP binding site [chemical binding]; other site 266117000198 Q-loop/lid; other site 266117000199 ABC transporter signature motif; other site 266117000200 Walker B; other site 266117000201 D-loop; other site 266117000202 H-loop/switch region; other site 266117000203 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266117000204 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266117000205 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266117000206 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117000207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000208 DNA-binding site [nucleotide binding]; DNA binding site 266117000209 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117000210 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117000211 Walker A/P-loop; other site 266117000212 ATP binding site [chemical binding]; other site 266117000213 Q-loop/lid; other site 266117000214 ABC transporter signature motif; other site 266117000215 Walker B; other site 266117000216 D-loop; other site 266117000217 H-loop/switch region; other site 266117000218 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266117000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117000220 dimer interface [polypeptide binding]; other site 266117000221 conserved gate region; other site 266117000222 putative PBP binding loops; other site 266117000223 ABC-ATPase subunit interface; other site 266117000224 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266117000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117000226 putative PBP binding loops; other site 266117000227 ABC-ATPase subunit interface; other site 266117000228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117000229 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266117000230 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 266117000231 alpha-mannosidase; Provisional; Region: PRK09819 266117000232 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 266117000233 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 266117000234 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 266117000235 metal binding site [ion binding]; metal-binding site 266117000236 putative dimer interface [polypeptide binding]; other site 266117000237 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266117000238 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266117000239 trimer interface [polypeptide binding]; other site 266117000240 active site 266117000241 substrate binding site [chemical binding]; other site 266117000242 CoA binding site [chemical binding]; other site 266117000243 succinyldiaminopimelate transaminase; Region: DapC; TIGR03537 266117000244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117000245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117000246 homodimer interface [polypeptide binding]; other site 266117000247 catalytic residue [active] 266117000248 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266117000249 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266117000250 active site 266117000251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266117000252 substrate binding site [chemical binding]; other site 266117000253 catalytic residues [active] 266117000254 dimer interface [polypeptide binding]; other site 266117000255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117000256 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117000257 putative substrate translocation pore; other site 266117000258 short chain dehydrogenase; Provisional; Region: PRK06138 266117000259 classical (c) SDRs; Region: SDR_c; cd05233 266117000260 NAD(P) binding site [chemical binding]; other site 266117000261 active site 266117000262 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266117000263 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117000264 substrate binding site [chemical binding]; other site 266117000265 ATP binding site [chemical binding]; other site 266117000266 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266117000267 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 266117000268 active site 266117000269 intersubunit interface [polypeptide binding]; other site 266117000270 catalytic residue [active] 266117000271 D-mannonate oxidoreductase; Provisional; Region: PRK08277 266117000272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117000273 NAD(P) binding site [chemical binding]; other site 266117000274 active site 266117000275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117000276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000277 DNA-binding site [nucleotide binding]; DNA binding site 266117000278 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266117000279 dimerization interface [polypeptide binding]; other site 266117000280 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 266117000281 ligand binding site [chemical binding]; other site 266117000282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117000283 active site 266117000284 TQO small subunit DoxD; Region: DoxD; pfam04173 266117000285 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266117000286 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266117000287 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 266117000288 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266117000289 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266117000290 iron-sulfur cluster [ion binding]; other site 266117000291 [2Fe-2S] cluster binding site [ion binding]; other site 266117000292 MarR family; Region: MarR; pfam01047 266117000293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117000294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117000295 Walker A/P-loop; other site 266117000296 ATP binding site [chemical binding]; other site 266117000297 Q-loop/lid; other site 266117000298 ABC transporter signature motif; other site 266117000299 Walker B; other site 266117000300 D-loop; other site 266117000301 H-loop/switch region; other site 266117000302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000303 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266117000304 Walker A motif; other site 266117000305 ATP binding site [chemical binding]; other site 266117000306 Walker B motif; other site 266117000307 arginine finger; other site 266117000308 Response regulator receiver domain; Region: Response_reg; pfam00072 266117000309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117000310 active site 266117000311 phosphorylation site [posttranslational modification] 266117000312 intermolecular recognition site; other site 266117000313 dimerization interface [polypeptide binding]; other site 266117000314 PAS fold; Region: PAS_4; pfam08448 266117000315 PAS domain S-box; Region: sensory_box; TIGR00229 266117000316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117000317 putative active site [active] 266117000318 heme pocket [chemical binding]; other site 266117000319 PAS domain S-box; Region: sensory_box; TIGR00229 266117000320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117000321 putative active site [active] 266117000322 heme pocket [chemical binding]; other site 266117000323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117000324 PAS domain; Region: PAS_9; pfam13426 266117000325 putative active site [active] 266117000326 heme pocket [chemical binding]; other site 266117000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000328 ATP binding site [chemical binding]; other site 266117000329 G-X-G motif; other site 266117000330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117000331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117000332 active site 266117000333 phosphorylation site [posttranslational modification] 266117000334 intermolecular recognition site; other site 266117000335 dimerization interface [polypeptide binding]; other site 266117000336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117000337 DNA binding residues [nucleotide binding] 266117000338 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266117000339 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266117000340 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266117000341 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266117000342 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266117000343 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266117000344 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266117000345 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266117000346 dimer interface [polypeptide binding]; other site 266117000347 active site 266117000348 catalytic residue [active] 266117000349 aspartate kinase; Reviewed; Region: PRK06635 266117000350 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266117000351 putative nucleotide binding site [chemical binding]; other site 266117000352 putative catalytic residues [active] 266117000353 putative Mg ion binding site [ion binding]; other site 266117000354 putative aspartate binding site [chemical binding]; other site 266117000355 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266117000356 putative allosteric regulatory site; other site 266117000357 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266117000358 putative allosteric regulatory residue; other site 266117000359 CAAX protease self-immunity; Region: Abi; pfam02517 266117000360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117000361 putative active site [active] 266117000362 PAS fold; Region: PAS_3; pfam08447 266117000363 heme pocket [chemical binding]; other site 266117000364 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266117000365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117000366 putative active site [active] 266117000367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117000368 dimer interface [polypeptide binding]; other site 266117000369 phosphorylation site [posttranslational modification] 266117000370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000371 ATP binding site [chemical binding]; other site 266117000372 G-X-G motif; other site 266117000373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117000374 Ligand Binding Site [chemical binding]; other site 266117000375 quinolinate synthetase; Provisional; Region: PRK09375 266117000376 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 266117000377 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266117000378 dimerization interface [polypeptide binding]; other site 266117000379 active site 266117000380 L-aspartate oxidase; Region: nadB; TIGR00551 266117000381 L-aspartate oxidase; Provisional; Region: PRK06175 266117000382 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266117000383 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266117000384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117000385 catalytic residue [active] 266117000386 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266117000387 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266117000388 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 266117000389 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266117000390 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266117000391 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266117000392 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266117000393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000394 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266117000395 Walker A motif; other site 266117000396 ATP binding site [chemical binding]; other site 266117000397 Walker B motif; other site 266117000398 arginine finger; other site 266117000399 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266117000400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266117000401 metal ion-dependent adhesion site (MIDAS); other site 266117000402 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266117000403 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266117000404 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266117000405 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266117000406 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266117000407 Ligand binding site; other site 266117000408 metal-binding site 266117000409 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266117000410 putative hydrophobic ligand binding site [chemical binding]; other site 266117000411 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266117000412 putative hydrophobic ligand binding site [chemical binding]; other site 266117000413 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266117000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117000415 S-adenosylmethionine binding site [chemical binding]; other site 266117000416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117000417 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117000418 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266117000419 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266117000420 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117000421 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117000422 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266117000423 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 266117000424 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 266117000425 NADH dehydrogenase; Region: NADHdh; cl00469 266117000426 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 266117000427 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 266117000428 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 266117000429 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266117000430 metal-binding site [ion binding] 266117000431 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 266117000432 putative homodimer interface [polypeptide binding]; other site 266117000433 putative homotetramer interface [polypeptide binding]; other site 266117000434 putative allosteric switch controlling residues; other site 266117000435 putative metal binding site [ion binding]; other site 266117000436 putative homodimer-homodimer interface [polypeptide binding]; other site 266117000437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266117000438 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266117000439 metal-binding site [ion binding] 266117000440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266117000441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117000442 motif II; other site 266117000443 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266117000444 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266117000445 putative active site [active] 266117000446 putative metal binding site [ion binding]; other site 266117000447 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117000448 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266117000449 TAP-like protein; Region: Abhydrolase_4; pfam08386 266117000450 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266117000451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000452 DNA-binding site [nucleotide binding]; DNA binding site 266117000453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117000455 homodimer interface [polypeptide binding]; other site 266117000456 catalytic residue [active] 266117000457 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266117000458 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266117000459 dimer interface [polypeptide binding]; other site 266117000460 active site 266117000461 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266117000462 EamA-like transporter family; Region: EamA; pfam00892 266117000463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117000464 Isochorismatase family; Region: Isochorismatase; pfam00857 266117000465 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266117000466 catalytic triad [active] 266117000467 conserved cis-peptide bond; other site 266117000468 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 266117000469 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266117000470 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266117000471 Na binding site [ion binding]; other site 266117000472 Protein of unknown function, DUF485; Region: DUF485; pfam04341 266117000473 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 266117000474 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266117000475 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266117000476 putative molybdopterin cofactor binding site [chemical binding]; other site 266117000477 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266117000478 putative molybdopterin cofactor binding site; other site 266117000479 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 266117000480 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 266117000481 NAD binding site [chemical binding]; other site 266117000482 catalytic Zn binding site [ion binding]; other site 266117000483 structural Zn binding site [ion binding]; other site 266117000484 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266117000485 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266117000486 putative active site [active] 266117000487 putative metal binding site [ion binding]; other site 266117000488 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266117000489 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266117000490 transmembrane helices; other site 266117000491 Transcriptional regulator [Transcription]; Region: LytR; COG1316 266117000492 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 266117000493 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266117000494 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266117000495 ligand binding site [chemical binding]; other site 266117000496 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266117000497 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117000498 Walker A/P-loop; other site 266117000499 ATP binding site [chemical binding]; other site 266117000500 Q-loop/lid; other site 266117000501 ABC transporter signature motif; other site 266117000502 Walker B; other site 266117000503 D-loop; other site 266117000504 H-loop/switch region; other site 266117000505 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117000506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117000507 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266117000508 TM-ABC transporter signature motif; other site 266117000509 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266117000510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117000511 TM-ABC transporter signature motif; other site 266117000512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117000513 Histidine kinase; Region: HisKA_3; pfam07730 266117000514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000515 ATP binding site [chemical binding]; other site 266117000516 Mg2+ binding site [ion binding]; other site 266117000517 G-X-G motif; other site 266117000518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117000519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117000520 active site 266117000521 phosphorylation site [posttranslational modification] 266117000522 intermolecular recognition site; other site 266117000523 dimerization interface [polypeptide binding]; other site 266117000524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117000525 DNA binding residues [nucleotide binding] 266117000526 dimerization interface [polypeptide binding]; other site 266117000527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117000528 non-specific DNA binding site [nucleotide binding]; other site 266117000529 salt bridge; other site 266117000530 sequence-specific DNA binding site [nucleotide binding]; other site 266117000531 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266117000532 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266117000533 trimerization site [polypeptide binding]; other site 266117000534 active site 266117000535 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266117000536 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266117000537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117000538 catalytic residue [active] 266117000539 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266117000540 [2Fe-2S] cluster binding site [ion binding]; other site 266117000541 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 266117000542 FeS assembly protein SufD; Region: sufD; TIGR01981 266117000543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117000544 Ligand Binding Site [chemical binding]; other site 266117000545 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 266117000546 FeS assembly protein SufB; Region: sufB; TIGR01980 266117000547 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 266117000548 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 266117000549 Walker A/P-loop; other site 266117000550 ATP binding site [chemical binding]; other site 266117000551 Q-loop/lid; other site 266117000552 ABC transporter signature motif; other site 266117000553 Walker B; other site 266117000554 D-loop; other site 266117000555 H-loop/switch region; other site 266117000556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117000557 S-adenosylmethionine binding site [chemical binding]; other site 266117000558 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266117000559 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266117000560 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117000561 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 266117000562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117000563 motif II; other site 266117000564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266117000565 DNA-binding site [nucleotide binding]; DNA binding site 266117000566 RNA-binding motif; other site 266117000567 hypothetical protein; Provisional; Region: PRK04194 266117000568 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266117000569 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 266117000570 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266117000571 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 266117000572 metal binding site [ion binding]; metal-binding site 266117000573 dimer interface [polypeptide binding]; other site 266117000574 Cupin domain; Region: Cupin_2; cl17218 266117000575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266117000576 active site 266117000577 ATP binding site [chemical binding]; other site 266117000578 substrate binding site [chemical binding]; other site 266117000579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117000580 activation loop (A-loop); other site 266117000581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266117000582 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266117000583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117000584 Walker A/P-loop; other site 266117000585 ATP binding site [chemical binding]; other site 266117000586 Q-loop/lid; other site 266117000587 ABC transporter signature motif; other site 266117000588 Walker B; other site 266117000589 D-loop; other site 266117000590 H-loop/switch region; other site 266117000591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117000592 dimer interface [polypeptide binding]; other site 266117000593 phosphorylation site [posttranslational modification] 266117000594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000595 ATP binding site [chemical binding]; other site 266117000596 Mg2+ binding site [ion binding]; other site 266117000597 G-X-G motif; other site 266117000598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117000599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117000600 active site 266117000601 phosphorylation site [posttranslational modification] 266117000602 intermolecular recognition site; other site 266117000603 dimerization interface [polypeptide binding]; other site 266117000604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117000605 DNA binding site [nucleotide binding] 266117000606 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266117000607 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266117000608 EamA-like transporter family; Region: EamA; cl17759 266117000609 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266117000610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266117000611 catalytic loop [active] 266117000612 iron binding site [ion binding]; other site 266117000613 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266117000614 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117000615 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 266117000616 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266117000617 putative ligand binding site [chemical binding]; other site 266117000618 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266117000619 TM-ABC transporter signature motif; other site 266117000620 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266117000621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266117000622 TM-ABC transporter signature motif; other site 266117000623 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266117000624 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266117000625 Walker A/P-loop; other site 266117000626 ATP binding site [chemical binding]; other site 266117000627 Q-loop/lid; other site 266117000628 ABC transporter signature motif; other site 266117000629 Walker B; other site 266117000630 D-loop; other site 266117000631 H-loop/switch region; other site 266117000632 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266117000633 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266117000634 Walker A/P-loop; other site 266117000635 ATP binding site [chemical binding]; other site 266117000636 Q-loop/lid; other site 266117000637 ABC transporter signature motif; other site 266117000638 Walker B; other site 266117000639 D-loop; other site 266117000640 H-loop/switch region; other site 266117000641 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266117000642 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 266117000643 tetramer interface [polypeptide binding]; other site 266117000644 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 266117000645 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 266117000646 tetramer interface [polypeptide binding]; other site 266117000647 active site 266117000648 metal binding site [ion binding]; metal-binding site 266117000649 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266117000650 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266117000651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117000652 active site 266117000653 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 266117000654 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266117000655 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266117000656 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117000657 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266117000658 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 266117000659 active site 266117000660 hypothetical protein; Provisional; Region: PRK08204 266117000661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117000662 active site 266117000663 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117000664 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266117000665 NAD(P) binding site [chemical binding]; other site 266117000666 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117000667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000668 DNA-binding site [nucleotide binding]; DNA binding site 266117000669 FCD domain; Region: FCD; pfam07729 266117000670 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266117000671 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117000672 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266117000673 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 266117000674 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 266117000675 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266117000676 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117000677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117000678 Coenzyme A binding pocket [chemical binding]; other site 266117000679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000680 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266117000681 Walker A motif; other site 266117000682 ATP binding site [chemical binding]; other site 266117000683 Walker B motif; other site 266117000684 arginine finger; other site 266117000685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117000686 Coenzyme A binding pocket [chemical binding]; other site 266117000687 Sterol carrier protein domain; Region: SCP2_2; pfam13530 266117000688 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 266117000689 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117000690 EamA-like transporter family; Region: EamA; pfam00892 266117000691 phenylhydantoinase; Validated; Region: PRK08323 266117000692 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266117000693 tetramer interface [polypeptide binding]; other site 266117000694 active site 266117000695 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266117000696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117000697 inhibitor-cofactor binding pocket; inhibition site 266117000698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117000699 catalytic residue [active] 266117000700 allantoate amidohydrolase; Reviewed; Region: PRK09290 266117000701 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266117000702 active site 266117000703 metal binding site [ion binding]; metal-binding site 266117000704 dimer interface [polypeptide binding]; other site 266117000705 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 266117000706 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266117000707 Na binding site [ion binding]; other site 266117000708 putative substrate binding site [chemical binding]; other site 266117000709 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117000710 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 266117000711 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266117000712 cytosine deaminase; Provisional; Region: PRK09230 266117000713 active site 266117000714 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266117000715 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117000716 Walker A/P-loop; other site 266117000717 ATP binding site [chemical binding]; other site 266117000718 Q-loop/lid; other site 266117000719 ABC transporter signature motif; other site 266117000720 Walker B; other site 266117000721 D-loop; other site 266117000722 H-loop/switch region; other site 266117000723 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117000724 Walker A/P-loop; other site 266117000725 ATP binding site [chemical binding]; other site 266117000726 Q-loop/lid; other site 266117000727 ABC transporter signature motif; other site 266117000728 Walker B; other site 266117000729 D-loop; other site 266117000730 H-loop/switch region; other site 266117000731 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 266117000732 QueT transporter; Region: QueT; cl01932 266117000733 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266117000734 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266117000735 homotetramer interface [polypeptide binding]; other site 266117000736 ligand binding site [chemical binding]; other site 266117000737 catalytic site [active] 266117000738 NAD binding site [chemical binding]; other site 266117000739 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266117000740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266117000741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117000742 hypothetical protein; Provisional; Region: PRK08609 266117000743 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 266117000744 active site 266117000745 primer binding site [nucleotide binding]; other site 266117000746 NTP binding site [chemical binding]; other site 266117000747 metal binding triad [ion binding]; metal-binding site 266117000748 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 266117000749 active site 266117000750 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266117000751 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266117000752 active site 266117000753 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266117000754 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266117000755 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266117000756 active site 266117000757 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117000758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000759 DNA-binding site [nucleotide binding]; DNA binding site 266117000760 FCD domain; Region: FCD; pfam07729 266117000761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117000762 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117000763 putative substrate translocation pore; other site 266117000764 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266117000765 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 266117000766 putative active site [active] 266117000767 catalytic triad [active] 266117000768 putative dimer interface [polypeptide binding]; other site 266117000769 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266117000770 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266117000771 amidase; Provisional; Region: PRK07486 266117000772 Amidase; Region: Amidase; pfam01425 266117000773 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266117000774 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266117000775 putative C-terminal domain interface [polypeptide binding]; other site 266117000776 putative GSH binding site (G-site) [chemical binding]; other site 266117000777 putative dimer interface [polypeptide binding]; other site 266117000778 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 266117000779 putative N-terminal domain interface [polypeptide binding]; other site 266117000780 putative dimer interface [polypeptide binding]; other site 266117000781 putative substrate binding pocket (H-site) [chemical binding]; other site 266117000782 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117000783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117000784 DNA-binding site [nucleotide binding]; DNA binding site 266117000785 FCD domain; Region: FCD; pfam07729 266117000786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266117000787 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266117000788 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117000789 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117000790 enoyl-CoA hydratase; Provisional; Region: PRK06144 266117000791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117000792 substrate binding site [chemical binding]; other site 266117000793 oxyanion hole (OAH) forming residues; other site 266117000794 trimer interface [polypeptide binding]; other site 266117000795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266117000796 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266117000797 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266117000798 trimer interface [polypeptide binding]; other site 266117000799 putative metal binding site [ion binding]; other site 266117000800 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117000801 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117000802 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117000803 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117000804 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266117000805 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266117000806 Catalytic site [active] 266117000807 4-alpha-glucanotransferase; Provisional; Region: PRK14508 266117000808 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 266117000809 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 266117000810 oligomer interface [polypeptide binding]; other site 266117000811 active site 266117000812 metal binding site [ion binding]; metal-binding site 266117000813 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 266117000814 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266117000815 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266117000816 NAD binding site [chemical binding]; other site 266117000817 ATP-grasp domain; Region: ATP-grasp; pfam02222 266117000818 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266117000819 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117000820 putative NAD(P) binding site [chemical binding]; other site 266117000821 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 266117000822 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 266117000823 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 266117000824 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661 266117000825 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 266117000826 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 266117000827 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 266117000828 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 266117000829 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 266117000830 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 266117000831 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 266117000832 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 266117000833 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 266117000834 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 266117000835 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 266117000836 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 266117000837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266117000838 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 266117000839 Family of unknown function (DUF694); Region: DUF694; pfam05107 266117000840 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 266117000841 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 266117000842 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266117000843 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266117000844 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 266117000845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117000846 ABC transporter signature motif; other site 266117000847 Walker B; other site 266117000848 D-loop; other site 266117000849 H-loop/switch region; other site 266117000850 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266117000851 active site 266117000852 HIGH motif; other site 266117000853 dimer interface [polypeptide binding]; other site 266117000854 KMSKS motif; other site 266117000855 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266117000856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117000857 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117000858 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266117000859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117000860 S-adenosylmethionine binding site [chemical binding]; other site 266117000861 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266117000862 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266117000863 substrate binding site [chemical binding]; other site 266117000864 ligand binding site [chemical binding]; other site 266117000865 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266117000866 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266117000867 substrate binding site [chemical binding]; other site 266117000868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117000869 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266117000870 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 266117000871 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 266117000872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266117000873 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266117000874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266117000875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117000876 S-adenosylmethionine binding site [chemical binding]; other site 266117000877 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 266117000878 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266117000879 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266117000880 DNA-binding site [nucleotide binding]; DNA binding site 266117000881 RNA-binding motif; other site 266117000882 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 266117000883 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266117000884 MutS domain I; Region: MutS_I; pfam01624 266117000885 MutS domain II; Region: MutS_II; pfam05188 266117000886 MutS domain III; Region: MutS_III; pfam05192 266117000887 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 266117000888 Walker A/P-loop; other site 266117000889 ATP binding site [chemical binding]; other site 266117000890 Q-loop/lid; other site 266117000891 ABC transporter signature motif; other site 266117000892 Walker B; other site 266117000893 D-loop; other site 266117000894 H-loop/switch region; other site 266117000895 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 266117000896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000897 ATP binding site [chemical binding]; other site 266117000898 Mg2+ binding site [ion binding]; other site 266117000899 G-X-G motif; other site 266117000900 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 266117000901 ATP binding site [chemical binding]; other site 266117000902 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 266117000903 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266117000904 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266117000905 QueT transporter; Region: QueT; cl01932 266117000906 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 266117000907 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266117000908 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 266117000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000910 Walker A motif; other site 266117000911 ATP binding site [chemical binding]; other site 266117000912 Walker B motif; other site 266117000913 arginine finger; other site 266117000914 UvrB/uvrC motif; Region: UVR; pfam02151 266117000915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117000916 Walker A motif; other site 266117000917 ATP binding site [chemical binding]; other site 266117000918 Walker B motif; other site 266117000919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266117000920 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266117000921 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 266117000922 C-terminal domain interface [polypeptide binding]; other site 266117000923 GSH binding site (G-site) [chemical binding]; other site 266117000924 dimer interface [polypeptide binding]; other site 266117000925 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 266117000926 N-terminal domain interface [polypeptide binding]; other site 266117000927 putative dimer interface [polypeptide binding]; other site 266117000928 active site 266117000929 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117000930 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 266117000931 CHASE domain; Region: CHASE; pfam03924 266117000932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117000933 dimer interface [polypeptide binding]; other site 266117000934 phosphorylation site [posttranslational modification] 266117000935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117000936 ATP binding site [chemical binding]; other site 266117000937 Mg2+ binding site [ion binding]; other site 266117000938 G-X-G motif; other site 266117000939 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266117000940 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 266117000941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117000942 catalytic residue [active] 266117000943 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266117000944 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 266117000945 putative active site [active] 266117000946 putative metal binding site [ion binding]; other site 266117000947 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266117000948 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266117000949 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 266117000950 active site 266117000951 catalytic site [active] 266117000952 metal binding site [ion binding]; metal-binding site 266117000953 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 266117000954 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266117000955 putative active site [active] 266117000956 putative metal binding site [ion binding]; other site 266117000957 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117000958 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117000959 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266117000960 PhoD-like phosphatase; Region: PhoD; pfam09423 266117000961 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266117000962 putative active site [active] 266117000963 putative metal binding site [ion binding]; other site 266117000964 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117000965 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 266117000966 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266117000967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266117000968 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117000969 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266117000970 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 266117000971 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 266117000972 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266117000973 active site 266117000974 homodimer interface [polypeptide binding]; other site 266117000975 catalytic site [active] 266117000976 acceptor binding site [chemical binding]; other site 266117000977 trehalose synthase; Region: treS_nterm; TIGR02456 266117000978 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 266117000979 active site 266117000980 catalytic site [active] 266117000981 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 266117000982 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 266117000983 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 266117000984 glycogen branching enzyme; Provisional; Region: PRK05402 266117000985 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266117000986 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266117000987 active site 266117000988 catalytic site [active] 266117000989 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266117000990 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266117000991 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266117000992 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266117000993 active site 266117000994 catalytic site [active] 266117000995 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 266117000996 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 266117000997 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 266117000998 catalytic site [active] 266117000999 active site 266117001000 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 266117001001 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 266117001002 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 266117001003 active site 266117001004 catalytic site [active] 266117001005 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266117001006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117001007 S-adenosylmethionine binding site [chemical binding]; other site 266117001008 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266117001009 oxidoreductase; Provisional; Region: PRK06196 266117001010 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266117001011 putative NAD(P) binding site [chemical binding]; other site 266117001012 active site 266117001013 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266117001014 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266117001015 inhibitor site; inhibition site 266117001016 active site 266117001017 dimer interface [polypeptide binding]; other site 266117001018 catalytic residue [active] 266117001019 Nucleoside recognition; Region: Gate; pfam07670 266117001020 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266117001021 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266117001022 nucleotide binding pocket [chemical binding]; other site 266117001023 K-X-D-G motif; other site 266117001024 catalytic site [active] 266117001025 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266117001026 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266117001027 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266117001028 Dimer interface [polypeptide binding]; other site 266117001029 PrcB C-terminal; Region: PrcB_C; pfam14343 266117001030 PRC-barrel domain; Region: PRC; pfam05239 266117001031 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266117001032 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266117001033 HSP70 interaction site [polypeptide binding]; other site 266117001034 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 266117001035 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117001036 active site 266117001037 catalytic site [active] 266117001038 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266117001039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266117001040 active site 266117001041 Int/Topo IB signature motif; other site 266117001042 DNA binding site [nucleotide binding] 266117001043 CCC1-related family of proteins; Region: CCC1_like; cl00278 266117001044 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266117001045 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266117001046 active site 266117001047 dimer interface [polypeptide binding]; other site 266117001048 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266117001049 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266117001050 active site 266117001051 FMN binding site [chemical binding]; other site 266117001052 substrate binding site [chemical binding]; other site 266117001053 3Fe-4S cluster binding site [ion binding]; other site 266117001054 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266117001055 domain interface; other site 266117001056 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266117001057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117001058 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266117001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117001060 S-adenosylmethionine binding site [chemical binding]; other site 266117001061 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 266117001062 Peptidase family M48; Region: Peptidase_M48; cl12018 266117001063 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266117001064 classical (c) SDRs; Region: SDR_c; cd05233 266117001065 NAD(P) binding site [chemical binding]; other site 266117001066 active site 266117001067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117001068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117001069 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266117001070 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266117001071 tetramer interface [polypeptide binding]; other site 266117001072 TPP-binding site [chemical binding]; other site 266117001073 heterodimer interface [polypeptide binding]; other site 266117001074 phosphorylation loop region [posttranslational modification] 266117001075 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117001076 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266117001077 alpha subunit interface [polypeptide binding]; other site 266117001078 TPP binding site [chemical binding]; other site 266117001079 heterodimer interface [polypeptide binding]; other site 266117001080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117001081 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266117001082 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266117001083 E3 interaction surface; other site 266117001084 lipoyl attachment site [posttranslational modification]; other site 266117001085 e3 binding domain; Region: E3_binding; pfam02817 266117001086 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266117001087 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117001088 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266117001089 NAD(P) binding site [chemical binding]; other site 266117001090 Putative cyclase; Region: Cyclase; pfam04199 266117001091 acyl-CoA synthetase; Validated; Region: PRK08316 266117001092 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117001093 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266117001094 acyl-activating enzyme (AAE) consensus motif; other site 266117001095 acyl-activating enzyme (AAE) consensus motif; other site 266117001096 putative AMP binding site [chemical binding]; other site 266117001097 putative active site [active] 266117001098 putative CoA binding site [chemical binding]; other site 266117001099 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266117001100 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 266117001101 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266117001102 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266117001103 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266117001104 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 266117001105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117001106 active site 266117001107 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266117001108 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266117001109 Walker A/P-loop; other site 266117001110 ATP binding site [chemical binding]; other site 266117001111 Q-loop/lid; other site 266117001112 ABC transporter signature motif; other site 266117001113 Walker B; other site 266117001114 D-loop; other site 266117001115 H-loop/switch region; other site 266117001116 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266117001117 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266117001118 Walker A/P-loop; other site 266117001119 ATP binding site [chemical binding]; other site 266117001120 Q-loop/lid; other site 266117001121 ABC transporter signature motif; other site 266117001122 Walker B; other site 266117001123 D-loop; other site 266117001124 H-loop/switch region; other site 266117001125 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266117001126 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266117001127 TM-ABC transporter signature motif; other site 266117001128 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266117001129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117001130 TM-ABC transporter signature motif; other site 266117001131 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266117001132 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 266117001133 putative ligand binding site [chemical binding]; other site 266117001134 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117001135 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266117001136 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117001137 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117001138 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117001139 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266117001140 Putative cyclase; Region: Cyclase; pfam04199 266117001141 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266117001142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266117001143 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 266117001144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117001145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117001146 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 266117001147 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266117001148 acyl-activating enzyme (AAE) consensus motif; other site 266117001149 putative AMP binding site [chemical binding]; other site 266117001150 putative active site [active] 266117001151 putative CoA binding site [chemical binding]; other site 266117001152 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266117001153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117001154 substrate binding site [chemical binding]; other site 266117001155 oxyanion hole (OAH) forming residues; other site 266117001156 trimer interface [polypeptide binding]; other site 266117001157 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 266117001158 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266117001159 NAD binding site [chemical binding]; other site 266117001160 homodimer interface [polypeptide binding]; other site 266117001161 homotetramer interface [polypeptide binding]; other site 266117001162 active site 266117001163 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117001164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001165 putative substrate translocation pore; other site 266117001166 acyl-coenzyme A oxidase; Region: PLN02526 266117001167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117001168 active site 266117001169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266117001170 active site 266117001171 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 266117001172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117001173 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 266117001174 active site 266117001175 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 266117001176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117001177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117001178 active site 266117001179 phosphorylation site [posttranslational modification] 266117001180 intermolecular recognition site; other site 266117001181 dimerization interface [polypeptide binding]; other site 266117001182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117001183 DNA binding site [nucleotide binding] 266117001184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 266117001185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266117001186 dimerization interface [polypeptide binding]; other site 266117001187 PAS domain; Region: PAS; smart00091 266117001188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117001189 dimer interface [polypeptide binding]; other site 266117001190 phosphorylation site [posttranslational modification] 266117001191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117001192 ATP binding site [chemical binding]; other site 266117001193 Mg2+ binding site [ion binding]; other site 266117001194 G-X-G motif; other site 266117001195 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 266117001196 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266117001197 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 266117001198 dimerization interface [polypeptide binding]; other site 266117001199 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266117001200 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 266117001201 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266117001202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117001203 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266117001204 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266117001205 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266117001206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266117001207 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117001208 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266117001209 EDD domain protein, DegV family; Region: DegV; TIGR00762 266117001210 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 266117001211 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 266117001212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117001213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117001214 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266117001215 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266117001216 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117001217 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117001218 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266117001219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117001220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117001221 TM-ABC transporter signature motif; other site 266117001222 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117001223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117001224 TM-ABC transporter signature motif; other site 266117001225 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266117001226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117001227 Walker A/P-loop; other site 266117001228 ATP binding site [chemical binding]; other site 266117001229 Q-loop/lid; other site 266117001230 ABC transporter signature motif; other site 266117001231 Walker B; other site 266117001232 D-loop; other site 266117001233 H-loop/switch region; other site 266117001234 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117001235 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266117001236 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117001237 putative ligand binding site [chemical binding]; other site 266117001238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117001239 putative DNA binding site [nucleotide binding]; other site 266117001240 putative Zn2+ binding site [ion binding]; other site 266117001241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266117001242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266117001243 nucleotide binding site [chemical binding]; other site 266117001244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266117001245 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 266117001246 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 266117001247 homotetramer interface [polypeptide binding]; other site 266117001248 FMN binding site [chemical binding]; other site 266117001249 homodimer contacts [polypeptide binding]; other site 266117001250 putative active site [active] 266117001251 putative substrate binding site [chemical binding]; other site 266117001252 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 266117001253 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266117001254 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266117001255 N- and C-terminal domain interface [polypeptide binding]; other site 266117001256 D-xylulose kinase; Region: XylB; TIGR01312 266117001257 active site 266117001258 MgATP binding site [chemical binding]; other site 266117001259 catalytic site [active] 266117001260 metal binding site [ion binding]; metal-binding site 266117001261 xylulose binding site [chemical binding]; other site 266117001262 homodimer interface [polypeptide binding]; other site 266117001263 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266117001264 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117001265 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 266117001266 protein binding site [polypeptide binding]; other site 266117001267 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 266117001268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117001269 Walker A/P-loop; other site 266117001270 ATP binding site [chemical binding]; other site 266117001271 Q-loop/lid; other site 266117001272 ABC transporter signature motif; other site 266117001273 Walker B; other site 266117001274 D-loop; other site 266117001275 H-loop/switch region; other site 266117001276 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266117001277 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266117001278 IucA / IucC family; Region: IucA_IucC; pfam04183 266117001279 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266117001280 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 266117001281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266117001282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 266117001283 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 266117001284 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266117001285 IucA / IucC family; Region: IucA_IucC; pfam04183 266117001286 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266117001287 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 266117001288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117001289 inhibitor-cofactor binding pocket; inhibition site 266117001290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117001291 catalytic residue [active] 266117001292 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 266117001293 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266117001294 siderophore binding site; other site 266117001295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266117001296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266117001297 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266117001298 putative PBP binding regions; other site 266117001299 ABC-ATPase subunit interface; other site 266117001300 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266117001301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266117001302 dimer interface [polypeptide binding]; other site 266117001303 putative PBP binding regions; other site 266117001304 ABC-ATPase subunit interface; other site 266117001305 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266117001306 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266117001307 Walker A/P-loop; other site 266117001308 ATP binding site [chemical binding]; other site 266117001309 Q-loop/lid; other site 266117001310 ABC transporter signature motif; other site 266117001311 Walker B; other site 266117001312 D-loop; other site 266117001313 H-loop/switch region; other site 266117001314 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266117001315 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 266117001316 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266117001317 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266117001318 siderophore binding site; other site 266117001319 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266117001320 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266117001321 intersubunit interface [polypeptide binding]; other site 266117001322 Protein of unknown function (DUF466); Region: DUF466; pfam04328 266117001323 carbon starvation protein A; Provisional; Region: PRK15015 266117001324 Carbon starvation protein CstA; Region: CstA; pfam02554 266117001325 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 266117001326 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117001327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117001328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117001329 Walker A/P-loop; other site 266117001330 ATP binding site [chemical binding]; other site 266117001331 Q-loop/lid; other site 266117001332 ABC transporter signature motif; other site 266117001333 Walker B; other site 266117001334 D-loop; other site 266117001335 H-loop/switch region; other site 266117001336 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266117001337 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266117001338 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117001339 FAD binding domain; Region: FAD_binding_4; pfam01565 266117001340 Berberine and berberine like; Region: BBE; pfam08031 266117001341 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266117001342 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 266117001343 SnoaL-like domain; Region: SnoaL_2; pfam12680 266117001344 Archaeal ATPase; Region: Arch_ATPase; pfam01637 266117001345 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 266117001346 Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the...; Region: Mth938; cd05126 266117001347 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266117001348 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266117001349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266117001350 catalytic loop [active] 266117001351 iron binding site [ion binding]; other site 266117001352 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117001353 Ligand Binding Site [chemical binding]; other site 266117001354 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117001355 Ligand Binding Site [chemical binding]; other site 266117001356 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 266117001357 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 266117001358 iron binding site [ion binding]; other site 266117001359 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 266117001360 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 266117001361 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 266117001362 Rubredoxin; Region: Rubredoxin; pfam00301 266117001363 iron binding site [ion binding]; other site 266117001364 hypothetical protein; Provisional; Region: PRK06185 266117001365 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266117001366 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266117001367 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 266117001368 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 266117001369 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117001370 Walker A/P-loop; other site 266117001371 ATP binding site [chemical binding]; other site 266117001372 Q-loop/lid; other site 266117001373 ABC transporter signature motif; other site 266117001374 Walker B; other site 266117001375 D-loop; other site 266117001376 H-loop/switch region; other site 266117001377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117001378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117001379 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 266117001380 Colicin V production protein; Region: Colicin_V; pfam02674 266117001381 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266117001382 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117001383 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 266117001384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117001385 FeS/SAM binding site; other site 266117001386 Uncharacterized conserved protein [Function unknown]; Region: COG3402 266117001387 Bacterial PH domain; Region: DUF304; pfam03703 266117001388 Bacterial PH domain; Region: DUF304; pfam03703 266117001389 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266117001390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117001391 active site 266117001392 metal binding site [ion binding]; metal-binding site 266117001393 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266117001394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117001395 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266117001396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117001397 ABC transporter signature motif; other site 266117001398 Walker B; other site 266117001399 D-loop; other site 266117001400 H-loop/switch region; other site 266117001401 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266117001402 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 266117001403 active site 266117001404 metal binding site [ion binding]; metal-binding site 266117001405 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 266117001406 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266117001407 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 266117001408 hypothetical protein; Provisional; Region: PRK06446 266117001409 metal binding site [ion binding]; metal-binding site 266117001410 dimer interface [polypeptide binding]; other site 266117001411 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 266117001412 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266117001413 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266117001414 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266117001415 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266117001416 Na binding site [ion binding]; other site 266117001417 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266117001418 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266117001419 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 266117001420 active site 266117001421 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266117001422 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266117001423 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266117001424 dimer interface [polypeptide binding]; other site 266117001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117001426 catalytic residue [active] 266117001427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001428 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117001429 putative substrate translocation pore; other site 266117001430 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117001431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117001432 putative Zn2+ binding site [ion binding]; other site 266117001433 putative DNA binding site [nucleotide binding]; other site 266117001434 dimerization interface [polypeptide binding]; other site 266117001435 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117001436 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 266117001437 amidohydrolase; Region: amidohydrolases; TIGR01891 266117001438 putative metal binding site [ion binding]; other site 266117001439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001440 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117001441 putative substrate translocation pore; other site 266117001442 amidase; Provisional; Region: PRK07487 266117001443 Amidase; Region: Amidase; cl11426 266117001444 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266117001445 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266117001446 dimer interface [polypeptide binding]; other site 266117001447 active site 266117001448 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266117001449 folate binding site [chemical binding]; other site 266117001450 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266117001451 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117001452 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266117001453 phenol 2-monooxygenase; Provisional; Region: PRK08294 266117001454 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266117001455 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 266117001456 dimer interface [polypeptide binding]; other site 266117001457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266117001458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117001459 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266117001460 dimerization interface [polypeptide binding]; other site 266117001461 substrate binding pocket [chemical binding]; other site 266117001462 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 266117001463 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266117001464 active site 266117001465 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266117001466 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 266117001467 active site 266117001468 Zn binding site [ion binding]; other site 266117001469 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 266117001470 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 266117001471 hypothetical protein; Reviewed; Region: PRK09588 266117001472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117001473 active site 266117001474 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266117001475 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266117001476 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266117001477 putative active site [active] 266117001478 putative metal binding site [ion binding]; other site 266117001479 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 266117001480 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117001481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266117001482 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266117001483 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 266117001484 hypothetical protein; Provisional; Region: PRK08609 266117001485 active site 266117001486 primer binding site [nucleotide binding]; other site 266117001487 NTP binding site [chemical binding]; other site 266117001488 metal binding triad [ion binding]; metal-binding site 266117001489 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 266117001490 active site 266117001491 Protein of unknown function DUF72; Region: DUF72; pfam01904 266117001492 AAA domain; Region: AAA_33; pfam13671 266117001493 AAA domain; Region: AAA_17; pfam13207 266117001494 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266117001495 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 266117001496 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266117001497 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117001498 substrate binding site [chemical binding]; other site 266117001499 ATP binding site [chemical binding]; other site 266117001500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117001501 PAS fold; Region: PAS_3; pfam08447 266117001502 putative active site [active] 266117001503 heme pocket [chemical binding]; other site 266117001504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117001505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117001506 metal binding site [ion binding]; metal-binding site 266117001507 active site 266117001508 I-site; other site 266117001509 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117001510 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266117001511 substrate binding pocket [chemical binding]; other site 266117001512 substrate-Mg2+ binding site; other site 266117001513 aspartate-rich region 1; other site 266117001514 aspartate-rich region 2; other site 266117001515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117001516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117001517 active site 266117001518 catalytic tetrad [active] 266117001519 hydrolase, alpha/beta fold family protein; Region: PLN02824 266117001520 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117001521 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266117001522 active site 266117001523 ATP binding site [chemical binding]; other site 266117001524 substrate binding site [chemical binding]; other site 266117001525 activation loop (A-loop); other site 266117001526 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266117001527 Tic20-like protein; Region: Tic20; pfam09685 266117001528 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266117001529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117001530 dimer interface [polypeptide binding]; other site 266117001531 conserved gate region; other site 266117001532 putative PBP binding loops; other site 266117001533 ABC-ATPase subunit interface; other site 266117001534 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266117001535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266117001536 substrate binding pocket [chemical binding]; other site 266117001537 membrane-bound complex binding site; other site 266117001538 hinge residues; other site 266117001539 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266117001540 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266117001541 Walker A/P-loop; other site 266117001542 ATP binding site [chemical binding]; other site 266117001543 Q-loop/lid; other site 266117001544 ABC transporter signature motif; other site 266117001545 Walker B; other site 266117001546 D-loop; other site 266117001547 H-loop/switch region; other site 266117001548 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266117001549 Fe-S cluster binding site [ion binding]; other site 266117001550 active site 266117001551 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 266117001552 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 266117001553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266117001554 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266117001555 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266117001556 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117001557 drug efflux system protein MdtG; Provisional; Region: PRK09874 266117001558 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266117001559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117001560 motif II; other site 266117001561 hypothetical protein; Validated; Region: PRK00153 266117001562 recombination protein RecR; Reviewed; Region: recR; PRK00076 266117001563 RecR protein; Region: RecR; pfam02132 266117001564 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266117001565 putative active site [active] 266117001566 putative metal-binding site [ion binding]; other site 266117001567 tetramer interface [polypeptide binding]; other site 266117001568 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 266117001569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266117001570 ATP binding site [chemical binding]; other site 266117001571 putative Mg++ binding site [ion binding]; other site 266117001572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266117001573 nucleotide binding region [chemical binding]; other site 266117001574 ATP-binding site [chemical binding]; other site 266117001575 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 266117001576 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266117001577 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266117001578 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 266117001579 NADP binding site [chemical binding]; other site 266117001580 substrate binding site [chemical binding]; other site 266117001581 active site 266117001582 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266117001583 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266117001584 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266117001585 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266117001586 catalytic site [active] 266117001587 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117001588 active site 266117001589 metal binding site [ion binding]; metal-binding site 266117001590 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 266117001591 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266117001592 Homeodomain-like domain; Region: HTH_23; pfam13384 266117001593 Winged helix-turn helix; Region: HTH_29; pfam13551 266117001594 Homeodomain-like domain; Region: HTH_32; pfam13565 266117001595 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 266117001596 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 266117001597 CrcB-like protein; Region: CRCB; pfam02537 266117001598 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 266117001599 Predicted transcriptional regulators [Transcription]; Region: COG1695 266117001600 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266117001601 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266117001602 transcriptional regulator NanR; Provisional; Region: PRK03837 266117001603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117001604 DNA-binding site [nucleotide binding]; DNA binding site 266117001605 FCD domain; Region: FCD; pfam07729 266117001606 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117001607 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266117001608 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266117001609 AP (apurinic/apyrimidinic) site pocket; other site 266117001610 DNA interaction; other site 266117001611 Metal-binding active site; metal-binding site 266117001612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117001613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117001614 classical (c) SDRs; Region: SDR_c; cd05233 266117001615 NAD(P) binding site [chemical binding]; other site 266117001616 active site 266117001617 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 266117001618 active site 266117001619 catalytic residues [active] 266117001620 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266117001621 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266117001622 iron-sulfur cluster [ion binding]; other site 266117001623 [2Fe-2S] cluster binding site [ion binding]; other site 266117001624 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266117001625 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266117001626 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 266117001627 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 266117001628 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 266117001629 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 266117001630 NADP binding site [chemical binding]; other site 266117001631 homodimer interface [polypeptide binding]; other site 266117001632 active site 266117001633 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266117001634 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117001635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117001636 DNA-binding site [nucleotide binding]; DNA binding site 266117001637 FCD domain; Region: FCD; pfam07729 266117001638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117001639 short chain dehydrogenase; Provisional; Region: PRK06138 266117001640 classical (c) SDRs; Region: SDR_c; cd05233 266117001641 NAD(P) binding site [chemical binding]; other site 266117001642 active site 266117001643 Cupin domain; Region: Cupin_2; pfam07883 266117001644 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266117001645 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 266117001646 NAD binding site [chemical binding]; other site 266117001647 substrate binding site [chemical binding]; other site 266117001648 catalytic Zn binding site [ion binding]; other site 266117001649 structural Zn binding site [ion binding]; other site 266117001650 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266117001651 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117001652 NAD(P) binding site [chemical binding]; other site 266117001653 catalytic residues [active] 266117001654 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266117001655 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117001656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117001657 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266117001658 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117001659 active site pocket [active] 266117001660 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266117001661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117001662 Walker A/P-loop; other site 266117001663 ATP binding site [chemical binding]; other site 266117001664 Q-loop/lid; other site 266117001665 ABC transporter signature motif; other site 266117001666 Walker B; other site 266117001667 D-loop; other site 266117001668 H-loop/switch region; other site 266117001669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117001670 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117001671 TM-ABC transporter signature motif; other site 266117001672 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266117001673 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117001674 putative ligand binding site [chemical binding]; other site 266117001675 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266117001676 classical (c) SDRs; Region: SDR_c; cd05233 266117001677 NAD(P) binding site [chemical binding]; other site 266117001678 active site 266117001679 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117001680 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266117001681 active site pocket [active] 266117001682 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117001683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117001684 DNA-binding site [nucleotide binding]; DNA binding site 266117001685 FCD domain; Region: FCD; pfam07729 266117001686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117001687 TPR motif; other site 266117001688 TPR repeat; Region: TPR_11; pfam13414 266117001689 binding surface 266117001690 Chain length determinant protein; Region: Wzz; cl15801 266117001691 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 266117001692 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 266117001693 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117001694 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266117001695 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117001696 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266117001697 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266117001698 putative metal binding site; other site 266117001699 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266117001700 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266117001701 Probable Catalytic site; other site 266117001702 metal-binding site 266117001703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266117001704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117001705 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266117001706 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266117001707 NADP-binding site; other site 266117001708 homotetramer interface [polypeptide binding]; other site 266117001709 substrate binding site [chemical binding]; other site 266117001710 homodimer interface [polypeptide binding]; other site 266117001711 active site 266117001712 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266117001713 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266117001714 NADP-binding site; other site 266117001715 homotetramer interface [polypeptide binding]; other site 266117001716 substrate binding site [chemical binding]; other site 266117001717 homodimer interface [polypeptide binding]; other site 266117001718 active site 266117001719 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 266117001720 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266117001721 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266117001722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266117001723 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266117001724 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266117001725 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 266117001726 Na binding site [ion binding]; other site 266117001727 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266117001728 active sites [active] 266117001729 tetramer interface [polypeptide binding]; other site 266117001730 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266117001731 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266117001732 Walker A/P-loop; other site 266117001733 ATP binding site [chemical binding]; other site 266117001734 Q-loop/lid; other site 266117001735 ABC transporter signature motif; other site 266117001736 Walker B; other site 266117001737 D-loop; other site 266117001738 H-loop/switch region; other site 266117001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117001740 dimer interface [polypeptide binding]; other site 266117001741 conserved gate region; other site 266117001742 ABC-ATPase subunit interface; other site 266117001743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117001744 ABC-ATPase subunit interface; other site 266117001745 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117001746 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266117001747 active sites [active] 266117001748 tetramer interface [polypeptide binding]; other site 266117001749 allantoate amidohydrolase; Reviewed; Region: PRK09290 266117001750 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266117001751 active site 266117001752 metal binding site [ion binding]; metal-binding site 266117001753 dimer interface [polypeptide binding]; other site 266117001754 urocanate hydratase; Provisional; Region: PRK05414 266117001755 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266117001756 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117001757 active site 266117001758 imidazolonepropionase; Validated; Region: PRK09356 266117001759 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266117001760 active site 266117001761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117001762 non-specific DNA binding site [nucleotide binding]; other site 266117001763 salt bridge; other site 266117001764 sequence-specific DNA binding site [nucleotide binding]; other site 266117001765 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 266117001766 YcfA-like protein; Region: YcfA; pfam07927 266117001767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117001768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117001769 active site 266117001770 phosphorylation site [posttranslational modification] 266117001771 intermolecular recognition site; other site 266117001772 dimerization interface [polypeptide binding]; other site 266117001773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117001774 DNA binding site [nucleotide binding] 266117001775 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266117001776 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 266117001777 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266117001778 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266117001779 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266117001780 metal-binding site [ion binding] 266117001781 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266117001782 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266117001783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117001784 dimerization interface [polypeptide binding]; other site 266117001785 putative DNA binding site [nucleotide binding]; other site 266117001786 putative Zn2+ binding site [ion binding]; other site 266117001787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266117001788 Cation efflux family; Region: Cation_efflux; cl00316 266117001789 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 266117001790 homodimer interaction site [polypeptide binding]; other site 266117001791 cofactor binding site; other site 266117001792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266117001793 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117001794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117001795 S-adenosylmethionine binding site [chemical binding]; other site 266117001796 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266117001797 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117001798 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266117001799 protein binding site [polypeptide binding]; other site 266117001800 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266117001801 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 266117001802 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 266117001803 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 266117001804 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 266117001805 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266117001806 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266117001807 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 266117001808 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266117001809 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 266117001810 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266117001811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117001812 phosphopentomutase; Provisional; Region: PRK05362 266117001813 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266117001814 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117001815 pyridoxamine kinase; Validated; Region: PRK05756 266117001816 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266117001817 dimer interface [polypeptide binding]; other site 266117001818 pyridoxal binding site [chemical binding]; other site 266117001819 ATP binding site [chemical binding]; other site 266117001820 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266117001821 MarR family; Region: MarR; pfam01047 266117001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117001824 putative substrate translocation pore; other site 266117001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001826 putative substrate translocation pore; other site 266117001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001828 putative substrate translocation pore; other site 266117001829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117001830 aconitate hydratase; Validated; Region: PRK09277 266117001831 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 266117001832 substrate binding site [chemical binding]; other site 266117001833 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 266117001834 ligand binding site [chemical binding]; other site 266117001835 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266117001836 substrate binding site [chemical binding]; other site 266117001837 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266117001838 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266117001839 dimerization interface [polypeptide binding]; other site 266117001840 ligand binding site [chemical binding]; other site 266117001841 NADP binding site [chemical binding]; other site 266117001842 catalytic site [active] 266117001843 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 266117001844 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266117001845 putative active site [active] 266117001846 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117001847 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266117001848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117001849 dimer interface [polypeptide binding]; other site 266117001850 conserved gate region; other site 266117001851 putative PBP binding loops; other site 266117001852 ABC-ATPase subunit interface; other site 266117001853 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266117001854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117001855 dimer interface [polypeptide binding]; other site 266117001856 conserved gate region; other site 266117001857 putative PBP binding loops; other site 266117001858 ABC-ATPase subunit interface; other site 266117001859 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 266117001860 Nucleotidyltransferase (NT) domain of an uncharacterized subgroup of the Pol beta-like NT superfamily; Region: NT_Pol-beta-like_1; cd07749 266117001861 metal binding triad [ion binding]; metal-binding site 266117001862 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266117001863 Beta-lactamase; Region: Beta-lactamase; pfam00144 266117001864 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 266117001865 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 266117001866 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266117001867 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266117001868 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266117001869 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117001870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117001871 DNA-binding site [nucleotide binding]; DNA binding site 266117001872 UTRA domain; Region: UTRA; pfam07702 266117001873 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117001874 classical (c) SDRs; Region: SDR_c; cd05233 266117001875 NAD(P) binding site [chemical binding]; other site 266117001876 active site 266117001877 cobyric acid synthase; Provisional; Region: PRK00784 266117001878 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117001879 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266117001880 catalytic triad [active] 266117001881 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 266117001882 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266117001883 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266117001884 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 266117001885 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266117001886 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 266117001887 metal ion-dependent adhesion site (MIDAS); other site 266117001888 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266117001889 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266117001890 Walker A motif; other site 266117001891 homodimer interface [polypeptide binding]; other site 266117001892 ATP binding site [chemical binding]; other site 266117001893 hydroxycobalamin binding site [chemical binding]; other site 266117001894 Walker B motif; other site 266117001895 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266117001896 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266117001897 catalytic triad [active] 266117001898 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 266117001899 active site 266117001900 SAM binding site [chemical binding]; other site 266117001901 homodimer interface [polypeptide binding]; other site 266117001902 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 266117001903 active site 266117001904 SAM binding site [chemical binding]; other site 266117001905 homodimer interface [polypeptide binding]; other site 266117001906 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 266117001907 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 266117001908 active site 266117001909 SAM binding site [chemical binding]; other site 266117001910 putative homodimer interface [polypeptide binding]; other site 266117001911 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 266117001912 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 266117001913 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 266117001914 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 266117001915 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 266117001916 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 266117001917 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 266117001918 active site 266117001919 SAM binding site [chemical binding]; other site 266117001920 homodimer interface [polypeptide binding]; other site 266117001921 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266117001922 Precorrin-8X methylmutase; Region: CbiC; pfam02570 266117001923 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 266117001924 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 266117001925 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266117001926 putative active site [active] 266117001927 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 266117001928 putative active site [active] 266117001929 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266117001930 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266117001931 putative dimer interface [polypeptide binding]; other site 266117001932 active site pocket [active] 266117001933 putative cataytic base [active] 266117001934 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 266117001935 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 266117001936 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266117001937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117001938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117001939 homodimer interface [polypeptide binding]; other site 266117001940 catalytic residue [active] 266117001941 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266117001942 catalytic core [active] 266117001943 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266117001944 homotrimer interface [polypeptide binding]; other site 266117001945 Walker A motif; other site 266117001946 GTP binding site [chemical binding]; other site 266117001947 Walker B motif; other site 266117001948 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 266117001949 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 266117001950 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266117001951 FeoA domain; Region: FeoA; pfam04023 266117001952 manganese transport protein MntH; Reviewed; Region: PRK00701 266117001953 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266117001954 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 266117001955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 266117001956 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266117001957 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 266117001958 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266117001959 active site 266117001960 dimer interface [polypeptide binding]; other site 266117001961 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 266117001962 putative ADP-ribose binding site [chemical binding]; other site 266117001963 putative active site [active] 266117001964 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266117001965 SelR domain; Region: SelR; pfam01641 266117001966 Sulfatase; Region: Sulfatase; pfam00884 266117001967 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117001968 Sulfatase; Region: Sulfatase; pfam00884 266117001969 photolyase PhrII; Region: phr2; TIGR00591 266117001970 DNA photolyase; Region: DNA_photolyase; pfam00875 266117001971 Domain of unknown function (DUF202); Region: DUF202; pfam02656 266117001972 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266117001973 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117001974 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266117001975 protein binding site [polypeptide binding]; other site 266117001976 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266117001977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117001978 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266117001979 putative active site [active] 266117001980 putative catalytic site [active] 266117001981 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266117001982 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266117001983 putative dimer interface [polypeptide binding]; other site 266117001984 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 266117001985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117001986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117001987 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266117001988 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266117001989 putative dimer interface [polypeptide binding]; other site 266117001990 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 266117001991 Clp amino terminal domain; Region: Clp_N; pfam02861 266117001992 Clp amino terminal domain; Region: Clp_N; pfam02861 266117001993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117001994 Walker A motif; other site 266117001995 ATP binding site [chemical binding]; other site 266117001996 Walker B motif; other site 266117001997 arginine finger; other site 266117001998 UvrB/uvrC motif; Region: UVR; pfam02151 266117001999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117002000 Walker A motif; other site 266117002001 ATP binding site [chemical binding]; other site 266117002002 Walker B motif; other site 266117002003 arginine finger; other site 266117002004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266117002005 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 266117002006 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 266117002007 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266117002008 active site 266117002009 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266117002010 PLD-like domain; Region: PLDc_2; pfam13091 266117002011 putative active site [active] 266117002012 catalytic site [active] 266117002013 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266117002014 PLD-like domain; Region: PLDc_2; pfam13091 266117002015 putative active site [active] 266117002016 catalytic site [active] 266117002017 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 266117002018 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 266117002019 active site 266117002020 substrate-binding site [chemical binding]; other site 266117002021 metal-binding site [ion binding] 266117002022 ATP binding site [chemical binding]; other site 266117002023 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 266117002024 dimanganese center [ion binding]; other site 266117002025 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266117002026 putative active site [active] 266117002027 putative metal binding site [ion binding]; other site 266117002028 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117002029 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 266117002030 OsmC-like protein; Region: OsmC; pfam02566 266117002031 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 266117002032 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 266117002033 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266117002034 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 266117002035 putative dimer interface [polypeptide binding]; other site 266117002036 putative active site [active] 266117002037 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 266117002038 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266117002039 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 266117002040 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266117002041 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117002042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117002043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117002044 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117002045 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 266117002046 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117002047 putative NAD(P) binding site [chemical binding]; other site 266117002048 Dot/Icm substrate protein; Region: SidE; pfam12252 266117002049 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 266117002050 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266117002051 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266117002052 active site 266117002053 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 266117002054 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266117002055 NlpC/P60 family; Region: NLPC_P60; pfam00877 266117002056 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266117002057 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266117002058 tandem repeat interface [polypeptide binding]; other site 266117002059 oligomer interface [polypeptide binding]; other site 266117002060 active site residues [active] 266117002061 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117002062 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 266117002063 putative active site [active] 266117002064 putative metal binding site [ion binding]; other site 266117002065 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 266117002066 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266117002067 nudix motif; other site 266117002068 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266117002069 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266117002070 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266117002071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117002072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117002073 active site 266117002074 phosphorylation site [posttranslational modification] 266117002075 intermolecular recognition site; other site 266117002076 dimerization interface [polypeptide binding]; other site 266117002077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117002078 dimerization interface [polypeptide binding]; other site 266117002079 DNA binding residues [nucleotide binding] 266117002080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117002081 Histidine kinase; Region: HisKA_3; pfam07730 266117002082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117002083 ATP binding site [chemical binding]; other site 266117002084 Mg2+ binding site [ion binding]; other site 266117002085 G-X-G motif; other site 266117002086 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 266117002087 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 266117002088 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 266117002089 active site 266117002090 homotrimer interface [polypeptide binding]; other site 266117002091 catalytic site [active] 266117002092 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 266117002093 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266117002094 classical (c) SDRs; Region: SDR_c; cd05233 266117002095 NAD(P) binding site [chemical binding]; other site 266117002096 active site 266117002097 Predicted membrane protein [Function unknown]; Region: COG2323 266117002098 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266117002099 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266117002100 putative active site [active] 266117002101 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266117002102 substrate binding site [chemical binding]; other site 266117002103 ATP binding site [chemical binding]; other site 266117002104 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 266117002105 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266117002106 active site 266117002107 nucleotide binding site [chemical binding]; other site 266117002108 HIGH motif; other site 266117002109 KMSKS motif; other site 266117002110 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266117002111 dimer interface [polypeptide binding]; other site 266117002112 active site 266117002113 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 266117002114 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 266117002115 putative ADP-binding pocket [chemical binding]; other site 266117002116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117002117 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117002118 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266117002119 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266117002120 putative active site [active] 266117002121 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266117002122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117002123 active site 266117002124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117002125 active site 266117002126 motif I; other site 266117002127 motif II; other site 266117002128 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 266117002129 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 266117002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117002131 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117002132 NAD(P) binding site [chemical binding]; other site 266117002133 active site 266117002134 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266117002135 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117002136 NAD binding site [chemical binding]; other site 266117002137 catalytic Zn binding site [ion binding]; other site 266117002138 structural Zn binding site [ion binding]; other site 266117002139 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 266117002140 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117002141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117002142 TIGR01777 family protein; Region: yfcH 266117002143 NAD(P) binding site [chemical binding]; other site 266117002144 active site 266117002145 prephenate dehydrogenase; Validated; Region: PRK06545 266117002146 prephenate dehydrogenase; Validated; Region: PRK08507 266117002147 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 266117002148 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266117002149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117002150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002151 homodimer interface [polypeptide binding]; other site 266117002152 catalytic residue [active] 266117002153 Chorismate mutase type II; Region: CM_2; pfam01817 266117002154 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 266117002155 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 266117002156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117002157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266117002158 active site 266117002159 ATP binding site [chemical binding]; other site 266117002160 substrate binding site [chemical binding]; other site 266117002161 activation loop (A-loop); other site 266117002162 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266117002163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266117002164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117002165 active site 266117002166 ATP binding site [chemical binding]; other site 266117002167 substrate binding site [chemical binding]; other site 266117002168 activation loop (A-loop); other site 266117002169 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266117002170 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117002171 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266117002172 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266117002173 DNA-binding site [nucleotide binding]; DNA binding site 266117002174 RNA-binding motif; other site 266117002175 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266117002176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266117002177 active site 266117002178 dimer interface [polypeptide binding]; other site 266117002179 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266117002180 active site 266117002181 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 266117002182 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 266117002183 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 266117002184 oligomer interface [polypeptide binding]; other site 266117002185 active site 266117002186 metal binding site [ion binding]; metal-binding site 266117002187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266117002188 EamA-like transporter family; Region: EamA; pfam00892 266117002189 EamA-like transporter family; Region: EamA; pfam00892 266117002190 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 266117002191 nucleotide binding site/active site [active] 266117002192 HIT family signature motif; other site 266117002193 catalytic residue [active] 266117002194 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266117002195 FAD binding domain; Region: FAD_binding_2; pfam00890 266117002196 hypothetical protein; Validated; Region: PRK07411 266117002197 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266117002198 ATP binding site [chemical binding]; other site 266117002199 substrate interface [chemical binding]; other site 266117002200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117002201 active site residue [active] 266117002202 Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977 266117002203 charged pocket; other site 266117002204 hydrophobic patch; other site 266117002205 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 266117002206 MPN+ (JAMM) motif; other site 266117002207 Zinc-binding site [ion binding]; other site 266117002208 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266117002209 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266117002210 dimer interface [polypeptide binding]; other site 266117002211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002212 catalytic residue [active] 266117002213 Chlorite dismutase; Region: Chlor_dismutase; cl01280 266117002214 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117002215 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117002216 active site 266117002217 catalytic tetrad [active] 266117002218 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266117002219 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266117002220 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 266117002221 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266117002222 DNA topoisomerase III; Provisional; Region: PRK07726 266117002223 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266117002224 active site 266117002225 putative interdomain interaction site [polypeptide binding]; other site 266117002226 putative metal-binding site [ion binding]; other site 266117002227 putative nucleotide binding site [chemical binding]; other site 266117002228 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266117002229 domain I; other site 266117002230 DNA binding groove [nucleotide binding] 266117002231 phosphate binding site [ion binding]; other site 266117002232 domain II; other site 266117002233 domain III; other site 266117002234 nucleotide binding site [chemical binding]; other site 266117002235 catalytic site [active] 266117002236 domain IV; other site 266117002237 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266117002238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117002239 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266117002240 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 266117002241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117002242 Walker A/P-loop; other site 266117002243 ATP binding site [chemical binding]; other site 266117002244 Q-loop/lid; other site 266117002245 ABC transporter signature motif; other site 266117002246 Walker B; other site 266117002247 D-loop; other site 266117002248 H-loop/switch region; other site 266117002249 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266117002250 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117002251 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 266117002252 BCCT family transporter; Region: BCCT; pfam02028 266117002253 choline dehydrogenase; Region: betA; TIGR01810 266117002254 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266117002255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117002256 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266117002257 NAD(P) binding site [chemical binding]; other site 266117002258 catalytic residues [active] 266117002259 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266117002260 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 266117002261 homodimer interface [polypeptide binding]; other site 266117002262 substrate-cofactor binding pocket; other site 266117002263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002264 catalytic residue [active] 266117002265 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 266117002266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266117002267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266117002268 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266117002269 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117002270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 266117002271 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266117002272 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266117002273 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117002274 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266117002275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266117002276 dimer interface [polypeptide binding]; other site 266117002277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002278 catalytic residue [active] 266117002279 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 266117002280 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266117002281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117002282 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 266117002283 FAD binding site [chemical binding]; other site 266117002284 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266117002285 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266117002286 Potassium binding sites [ion binding]; other site 266117002287 Cesium cation binding sites [ion binding]; other site 266117002288 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266117002289 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117002290 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266117002291 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266117002292 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117002293 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117002294 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117002295 Sulfatase; Region: Sulfatase; pfam00884 266117002296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117002297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117002298 active site 266117002299 metal binding site [ion binding]; metal-binding site 266117002300 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266117002301 glycyl-tRNA synthetase; Provisional; Region: PRK04173 266117002302 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266117002303 motif 1; other site 266117002304 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 266117002305 active site 266117002306 motif 2; other site 266117002307 motif 3; other site 266117002308 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 266117002309 anticodon binding site; other site 266117002310 2-phosphoglycerate kinase; Provisional; Region: PRK04220 266117002311 YtxH-like protein; Region: YtxH; cl02079 266117002312 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266117002313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266117002314 dimerization interface [polypeptide binding]; other site 266117002315 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266117002316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117002317 dimer interface [polypeptide binding]; other site 266117002318 phosphorylation site [posttranslational modification] 266117002319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117002320 ATP binding site [chemical binding]; other site 266117002321 Mg2+ binding site [ion binding]; other site 266117002322 G-X-G motif; other site 266117002323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117002325 active site 266117002326 phosphorylation site [posttranslational modification] 266117002327 intermolecular recognition site; other site 266117002328 dimerization interface [polypeptide binding]; other site 266117002329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117002330 DNA binding site [nucleotide binding] 266117002331 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266117002332 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 266117002333 nucleotide binding site [chemical binding]; other site 266117002334 NEF interaction site [polypeptide binding]; other site 266117002335 SBD interface [polypeptide binding]; other site 266117002336 GrpE; Region: GrpE; pfam01025 266117002337 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266117002338 dimer interface [polypeptide binding]; other site 266117002339 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266117002340 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 266117002341 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266117002342 HSP70 interaction site [polypeptide binding]; other site 266117002343 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266117002344 Zn binding sites [ion binding]; other site 266117002345 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266117002346 dimer interface [polypeptide binding]; other site 266117002347 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 266117002348 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266117002349 DNA binding residues [nucleotide binding] 266117002350 putative dimer interface [polypeptide binding]; other site 266117002351 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 266117002352 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 266117002353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266117002354 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 266117002355 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 266117002356 Ligand binding site; other site 266117002357 Putative Catalytic site; other site 266117002358 DXD motif; other site 266117002359 Predicted membrane protein [Function unknown]; Region: COG2246 266117002360 GtrA-like protein; Region: GtrA; pfam04138 266117002361 GAF domain; Region: GAF_3; pfam13492 266117002362 GAF domain; Region: GAF_2; pfam13185 266117002363 Acylphosphatase; Region: Acylphosphatase; cl00551 266117002364 ribonuclease HIII; Provisional; Region: PRK00996 266117002365 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 266117002366 RNA/DNA hybrid binding site [nucleotide binding]; other site 266117002367 active site 266117002368 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266117002369 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266117002370 tetramer interface [polypeptide binding]; other site 266117002371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002372 catalytic residue [active] 266117002373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117002374 Coenzyme A binding pocket [chemical binding]; other site 266117002375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266117002376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117002377 Coenzyme A binding pocket [chemical binding]; other site 266117002378 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266117002379 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266117002380 glutaminase active site [active] 266117002381 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266117002382 dimer interface [polypeptide binding]; other site 266117002383 active site 266117002384 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266117002385 dimer interface [polypeptide binding]; other site 266117002386 active site 266117002387 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266117002388 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266117002389 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266117002390 Uncharacterized conserved protein [Function unknown]; Region: COG0062 266117002391 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266117002392 putative substrate binding site [chemical binding]; other site 266117002393 putative ATP binding site [chemical binding]; other site 266117002394 FOG: CBS domain [General function prediction only]; Region: COG0517 266117002395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266117002396 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266117002397 alanine racemase; Reviewed; Region: alr; PRK00053 266117002398 active site 266117002399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266117002400 dimer interface [polypeptide binding]; other site 266117002401 substrate binding site [chemical binding]; other site 266117002402 catalytic residues [active] 266117002403 HD domain; Region: HD; pfam01966 266117002404 PspC domain; Region: PspC; cl00864 266117002405 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266117002406 Fe-S cluster binding site [ion binding]; other site 266117002407 active site 266117002408 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266117002409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266117002410 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 266117002411 Glycoprotease family; Region: Peptidase_M22; pfam00814 266117002412 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266117002413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117002414 Coenzyme A binding pocket [chemical binding]; other site 266117002415 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 266117002416 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 266117002417 Peptidase family M23; Region: Peptidase_M23; pfam01551 266117002418 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266117002419 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266117002420 ring oligomerisation interface [polypeptide binding]; other site 266117002421 ATP/Mg binding site [chemical binding]; other site 266117002422 stacking interactions; other site 266117002423 hinge regions; other site 266117002424 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 266117002425 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266117002426 active site 266117002427 GMP synthase; Reviewed; Region: guaA; PRK00074 266117002428 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266117002429 AMP/PPi binding site [chemical binding]; other site 266117002430 candidate oxyanion hole; other site 266117002431 catalytic triad [active] 266117002432 potential glutamine specificity residues [chemical binding]; other site 266117002433 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266117002434 ATP Binding subdomain [chemical binding]; other site 266117002435 Ligand Binding sites [chemical binding]; other site 266117002436 Dimerization subdomain; other site 266117002437 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 266117002438 putative catalytic site [active] 266117002439 putative metal binding site [ion binding]; other site 266117002440 putative phosphate binding site [ion binding]; other site 266117002441 PBP superfamily domain; Region: PBP_like_2; cl17296 266117002442 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 266117002443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002444 dimer interface [polypeptide binding]; other site 266117002445 conserved gate region; other site 266117002446 putative PBP binding loops; other site 266117002447 ABC-ATPase subunit interface; other site 266117002448 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266117002449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002450 dimer interface [polypeptide binding]; other site 266117002451 conserved gate region; other site 266117002452 putative PBP binding loops; other site 266117002453 ABC-ATPase subunit interface; other site 266117002454 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 266117002455 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266117002456 Walker A/P-loop; other site 266117002457 ATP binding site [chemical binding]; other site 266117002458 Q-loop/lid; other site 266117002459 ABC transporter signature motif; other site 266117002460 Walker B; other site 266117002461 D-loop; other site 266117002462 H-loop/switch region; other site 266117002463 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 266117002464 PhoU domain; Region: PhoU; pfam01895 266117002465 PhoU domain; Region: PhoU; pfam01895 266117002466 Rrf2 family protein; Region: rrf2_super; TIGR00738 266117002467 Transcriptional regulator; Region: Rrf2; pfam02082 266117002468 Putative methyltransferase; Region: Methyltransf_16; pfam10294 266117002469 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 266117002470 Part of AAA domain; Region: AAA_19; pfam13245 266117002471 Family description; Region: UvrD_C_2; pfam13538 266117002472 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 266117002473 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 266117002474 DRTGG domain; Region: DRTGG; pfam07085 266117002475 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266117002476 DHH family; Region: DHH; pfam01368 266117002477 DHHA2 domain; Region: DHHA2; pfam02833 266117002478 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 266117002479 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266117002480 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266117002481 homodimer interface [polypeptide binding]; other site 266117002482 NADP binding site [chemical binding]; other site 266117002483 substrate binding site [chemical binding]; other site 266117002484 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 266117002485 cleavage site 266117002486 active site 266117002487 substrate binding sites [chemical binding]; other site 266117002488 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266117002489 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266117002490 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266117002491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266117002492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266117002493 DNA binding site [nucleotide binding] 266117002494 domain linker motif; other site 266117002495 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266117002496 dimerization interface [polypeptide binding]; other site 266117002497 ligand binding site [chemical binding]; other site 266117002498 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 266117002499 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 266117002500 hexamer (dimer of trimers) interface [polypeptide binding]; other site 266117002501 trimer interface [polypeptide binding]; other site 266117002502 substrate binding site [chemical binding]; other site 266117002503 Mn binding site [ion binding]; other site 266117002504 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266117002505 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 266117002506 N- and C-terminal domain interface [polypeptide binding]; other site 266117002507 putative active site [active] 266117002508 MgATP binding site [chemical binding]; other site 266117002509 catalytic site [active] 266117002510 metal binding site [ion binding]; metal-binding site 266117002511 putative xylulose binding site [chemical binding]; other site 266117002512 putative homodimer interface [polypeptide binding]; other site 266117002513 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266117002514 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266117002515 GatB domain; Region: GatB_Yqey; smart00845 266117002516 Dehydratase family; Region: ILVD_EDD; cl00340 266117002517 Dehydratase family; Region: ILVD_EDD; cl00340 266117002518 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266117002519 homodimer interface [polypeptide binding]; other site 266117002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002521 catalytic residue [active] 266117002522 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 266117002523 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266117002524 ligand binding site [chemical binding]; other site 266117002525 NAD binding site [chemical binding]; other site 266117002526 dimerization interface [polypeptide binding]; other site 266117002527 catalytic site [active] 266117002528 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 266117002529 putative L-serine binding site [chemical binding]; other site 266117002530 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266117002531 YjzC-like protein; Region: YjzC; pfam14168 266117002532 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266117002533 substrate binding site [chemical binding]; other site 266117002534 THF binding site; other site 266117002535 zinc-binding site [ion binding]; other site 266117002536 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 266117002537 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 266117002538 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 266117002539 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 266117002540 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266117002541 FAD binding site [chemical binding]; other site 266117002542 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266117002543 active site lid residues [active] 266117002544 substrate binding pocket [chemical binding]; other site 266117002545 catalytic residues [active] 266117002546 substrate-Mg2+ binding site; other site 266117002547 aspartate-rich region 1; other site 266117002548 aspartate-rich region 2; other site 266117002549 phytoene desaturase; Region: crtI_fam; TIGR02734 266117002550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117002551 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266117002552 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 266117002553 putative RNA binding site [nucleotide binding]; other site 266117002554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117002555 S-adenosylmethionine binding site [chemical binding]; other site 266117002556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266117002557 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 266117002558 FtsX-like permease family; Region: FtsX; pfam02687 266117002559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266117002560 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 266117002561 FtsX-like permease family; Region: FtsX; pfam02687 266117002562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266117002563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266117002564 Walker A/P-loop; other site 266117002565 ATP binding site [chemical binding]; other site 266117002566 Q-loop/lid; other site 266117002567 ABC transporter signature motif; other site 266117002568 Walker B; other site 266117002569 D-loop; other site 266117002570 H-loop/switch region; other site 266117002571 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 266117002572 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266117002573 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266117002574 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266117002575 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266117002576 replicative DNA helicase; Region: DnaB; TIGR00665 266117002577 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266117002578 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266117002579 Walker A motif; other site 266117002580 ATP binding site [chemical binding]; other site 266117002581 Walker B motif; other site 266117002582 DNA binding loops [nucleotide binding] 266117002583 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 266117002584 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266117002585 NAD binding site [chemical binding]; other site 266117002586 homotetramer interface [polypeptide binding]; other site 266117002587 homodimer interface [polypeptide binding]; other site 266117002588 substrate binding site [chemical binding]; other site 266117002589 active site 266117002590 Sulfatase; Region: Sulfatase; pfam00884 266117002591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266117002592 TPR motif; other site 266117002593 acetyl-CoA synthetase; Provisional; Region: PRK00174 266117002594 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266117002595 active site 266117002596 CoA binding site [chemical binding]; other site 266117002597 acyl-activating enzyme (AAE) consensus motif; other site 266117002598 AMP binding site [chemical binding]; other site 266117002599 acetate binding site [chemical binding]; other site 266117002600 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266117002601 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 266117002602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266117002603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117002604 ligand binding site [chemical binding]; other site 266117002605 flexible hinge region; other site 266117002606 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266117002607 non-specific DNA interactions [nucleotide binding]; other site 266117002608 DNA binding site [nucleotide binding] 266117002609 sequence specific DNA binding site [nucleotide binding]; other site 266117002610 putative cAMP binding site [chemical binding]; other site 266117002611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117002612 Zn2+ binding site [ion binding]; other site 266117002613 Mg2+ binding site [ion binding]; other site 266117002614 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266117002615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117002616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117002617 DNA binding residues [nucleotide binding] 266117002618 Uncharacterized conserved protein [Function unknown]; Region: COG1315 266117002619 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 266117002620 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266117002621 peptide binding site [polypeptide binding]; other site 266117002622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266117002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002624 dimer interface [polypeptide binding]; other site 266117002625 conserved gate region; other site 266117002626 putative PBP binding loops; other site 266117002627 ABC-ATPase subunit interface; other site 266117002628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266117002629 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266117002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002631 dimer interface [polypeptide binding]; other site 266117002632 conserved gate region; other site 266117002633 putative PBP binding loops; other site 266117002634 ABC-ATPase subunit interface; other site 266117002635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266117002636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117002637 Walker A/P-loop; other site 266117002638 ATP binding site [chemical binding]; other site 266117002639 Q-loop/lid; other site 266117002640 ABC transporter signature motif; other site 266117002641 Walker B; other site 266117002642 D-loop; other site 266117002643 H-loop/switch region; other site 266117002644 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266117002645 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266117002646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117002647 Walker A/P-loop; other site 266117002648 ATP binding site [chemical binding]; other site 266117002649 Q-loop/lid; other site 266117002650 ABC transporter signature motif; other site 266117002651 Walker B; other site 266117002652 D-loop; other site 266117002653 H-loop/switch region; other site 266117002654 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266117002655 Uncharacterized conserved protein [Function unknown]; Region: COG3342 266117002656 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 266117002657 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 266117002658 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266117002659 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 266117002660 peptide binding site [polypeptide binding]; other site 266117002661 dimer interface [polypeptide binding]; other site 266117002662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266117002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002664 dimer interface [polypeptide binding]; other site 266117002665 conserved gate region; other site 266117002666 putative PBP binding loops; other site 266117002667 ABC-ATPase subunit interface; other site 266117002668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266117002669 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266117002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117002671 dimer interface [polypeptide binding]; other site 266117002672 conserved gate region; other site 266117002673 putative PBP binding loops; other site 266117002674 ABC-ATPase subunit interface; other site 266117002675 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266117002676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117002677 Walker A/P-loop; other site 266117002678 ATP binding site [chemical binding]; other site 266117002679 Q-loop/lid; other site 266117002680 ABC transporter signature motif; other site 266117002681 Walker B; other site 266117002682 D-loop; other site 266117002683 H-loop/switch region; other site 266117002684 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266117002685 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 266117002686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117002687 Walker A/P-loop; other site 266117002688 ATP binding site [chemical binding]; other site 266117002689 Q-loop/lid; other site 266117002690 ABC transporter signature motif; other site 266117002691 Walker B; other site 266117002692 D-loop; other site 266117002693 H-loop/switch region; other site 266117002694 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266117002695 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266117002696 C-terminal peptidase (prc); Region: prc; TIGR00225 266117002697 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266117002698 protein binding site [polypeptide binding]; other site 266117002699 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266117002700 Catalytic dyad [active] 266117002701 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266117002702 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 266117002703 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266117002704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117002705 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117002706 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117002707 DNA binding residues [nucleotide binding] 266117002708 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 266117002709 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266117002710 MarR family; Region: MarR; pfam01047 266117002711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117002712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117002713 DNA binding residues [nucleotide binding] 266117002714 Cupin domain; Region: Cupin_2; pfam07883 266117002715 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266117002716 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266117002717 iron-sulfur cluster [ion binding]; other site 266117002718 [2Fe-2S] cluster binding site [ion binding]; other site 266117002719 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266117002720 PLD-like domain; Region: PLDc_2; pfam13091 266117002721 putative active site [active] 266117002722 catalytic site [active] 266117002723 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266117002724 PLD-like domain; Region: PLDc_2; pfam13091 266117002725 putative active site [active] 266117002726 catalytic site [active] 266117002727 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 266117002728 DHH family; Region: DHH; pfam01368 266117002729 DHHA1 domain; Region: DHHA1; pfam02272 266117002730 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266117002731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266117002732 nucleotide binding site [chemical binding]; other site 266117002733 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266117002734 Predicted methyltransferases [General function prediction only]; Region: COG0313 266117002735 putative SAM binding site [chemical binding]; other site 266117002736 putative homodimer interface [polypeptide binding]; other site 266117002737 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266117002738 active site 266117002739 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266117002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117002741 S-adenosylmethionine binding site [chemical binding]; other site 266117002742 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 266117002743 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 266117002744 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266117002745 Substrate binding site; other site 266117002746 Mg++ binding site; other site 266117002747 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266117002748 active site 266117002749 substrate binding site [chemical binding]; other site 266117002750 CoA binding site [chemical binding]; other site 266117002751 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266117002752 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266117002753 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117002754 active site 266117002755 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266117002756 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266117002757 5S rRNA interface [nucleotide binding]; other site 266117002758 CTC domain interface [polypeptide binding]; other site 266117002759 L16 interface [polypeptide binding]; other site 266117002760 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266117002761 putative active site [active] 266117002762 catalytic residue [active] 266117002763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117002764 DNA-binding site [nucleotide binding]; DNA binding site 266117002765 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266117002766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117002767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117002768 DNA binding residues [nucleotide binding] 266117002769 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266117002770 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266117002771 DNA binding site [nucleotide binding] 266117002772 active site 266117002773 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266117002774 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266117002775 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266117002776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117002777 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 266117002778 NAD(P) binding site [chemical binding]; other site 266117002779 catalytic residues [active] 266117002780 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266117002781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117002782 motif II; other site 266117002783 Predicted transcriptional regulators [Transcription]; Region: COG1733 266117002784 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266117002785 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266117002786 CoenzymeA binding site [chemical binding]; other site 266117002787 subunit interaction site [polypeptide binding]; other site 266117002788 PHB binding site; other site 266117002789 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266117002790 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266117002791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266117002792 ATP binding site [chemical binding]; other site 266117002793 putative Mg++ binding site [ion binding]; other site 266117002794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266117002795 nucleotide binding region [chemical binding]; other site 266117002796 ATP-binding site [chemical binding]; other site 266117002797 TRCF domain; Region: TRCF; pfam03461 266117002798 Uncharacterized conserved protein [Function unknown]; Region: COG1683 266117002799 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 266117002800 SurA N-terminal domain; Region: SurA_N; pfam09312 266117002801 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266117002802 enolase; Provisional; Region: eno; PRK00077 266117002803 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266117002804 dimer interface [polypeptide binding]; other site 266117002805 metal binding site [ion binding]; metal-binding site 266117002806 substrate binding pocket [chemical binding]; other site 266117002807 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 266117002808 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266117002809 domain interfaces; other site 266117002810 active site 266117002811 Septum formation initiator; Region: DivIC; pfam04977 266117002812 Protein of unknown function (DUF501); Region: DUF501; pfam04417 266117002813 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117002814 Ligand Binding Site [chemical binding]; other site 266117002815 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 266117002816 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 266117002817 4Fe-4S binding domain; Region: Fer4; pfam00037 266117002818 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 266117002819 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266117002820 dimer interface [polypeptide binding]; other site 266117002821 PYR/PP interface [polypeptide binding]; other site 266117002822 TPP binding site [chemical binding]; other site 266117002823 substrate binding site [chemical binding]; other site 266117002824 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 266117002825 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 266117002826 TPP-binding site [chemical binding]; other site 266117002827 putative dimer interface [polypeptide binding]; other site 266117002828 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266117002829 homodimer interface [polypeptide binding]; other site 266117002830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117002831 catalytic residue [active] 266117002832 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266117002833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266117002834 sequence-specific DNA binding site [nucleotide binding]; other site 266117002835 salt bridge; other site 266117002836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266117002837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117002838 non-specific DNA binding site [nucleotide binding]; other site 266117002839 salt bridge; other site 266117002840 sequence-specific DNA binding site [nucleotide binding]; other site 266117002841 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117002842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117002843 DNA-binding site [nucleotide binding]; DNA binding site 266117002844 FCD domain; Region: FCD; pfam07729 266117002845 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 266117002846 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 266117002847 catalytic core [active] 266117002848 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 266117002849 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266117002850 substrate binding site [chemical binding]; other site 266117002851 THF binding site; other site 266117002852 zinc-binding site [ion binding]; other site 266117002853 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 266117002854 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266117002855 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 266117002856 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266117002857 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117002858 NAD(P) binding site [chemical binding]; other site 266117002859 FOG: CBS domain [General function prediction only]; Region: COG0517 266117002860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 266117002861 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 266117002862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117002863 extended (e) SDRs; Region: SDR_e; cd08946 266117002864 NAD(P) binding site [chemical binding]; other site 266117002865 active site 266117002866 substrate binding site [chemical binding]; other site 266117002867 Putative zinc-finger; Region: zf-HC2; pfam13490 266117002868 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266117002869 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 266117002870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117002871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117002872 DNA binding residues [nucleotide binding] 266117002873 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117002874 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266117002875 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266117002876 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266117002877 NADP binding site [chemical binding]; other site 266117002878 dimer interface [polypeptide binding]; other site 266117002879 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117002880 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266117002881 active site 266117002882 ATP binding site [chemical binding]; other site 266117002883 substrate binding site [chemical binding]; other site 266117002884 activation loop (A-loop); other site 266117002885 benzoylformate decarboxylase; Reviewed; Region: PRK07092 266117002886 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117002887 PYR/PP interface [polypeptide binding]; other site 266117002888 dimer interface [polypeptide binding]; other site 266117002889 TPP binding site [chemical binding]; other site 266117002890 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117002891 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266117002892 TPP-binding site [chemical binding]; other site 266117002893 dimer interface [polypeptide binding]; other site 266117002894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266117002895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266117002896 DNA binding site [nucleotide binding] 266117002897 domain linker motif; other site 266117002898 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266117002899 dimerization interface [polypeptide binding]; other site 266117002900 ligand binding site [chemical binding]; other site 266117002901 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266117002902 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117002903 Walker A/P-loop; other site 266117002904 ATP binding site [chemical binding]; other site 266117002905 Q-loop/lid; other site 266117002906 ABC transporter signature motif; other site 266117002907 Walker B; other site 266117002908 D-loop; other site 266117002909 H-loop/switch region; other site 266117002910 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117002911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117002912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117002913 TM-ABC transporter signature motif; other site 266117002914 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 266117002915 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 266117002916 ligand binding site [chemical binding]; other site 266117002917 dimerization interface [polypeptide binding]; other site 266117002918 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266117002919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117002920 substrate binding site [chemical binding]; other site 266117002921 dimer interface [polypeptide binding]; other site 266117002922 ATP binding site [chemical binding]; other site 266117002923 D-ribose pyranase; Provisional; Region: PRK11797 266117002924 Sulphur transport; Region: Sulf_transp; pfam04143 266117002925 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266117002926 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 266117002927 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 266117002928 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 266117002929 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266117002930 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266117002931 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117002932 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 266117002933 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 266117002934 dimer interface [polypeptide binding]; other site 266117002935 substrate binding site [chemical binding]; other site 266117002936 phosphate binding site [ion binding]; other site 266117002937 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 266117002938 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 266117002939 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266117002940 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 266117002941 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 266117002942 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266117002943 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266117002944 Active Sites [active] 266117002945 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 266117002946 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266117002947 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266117002948 4Fe-4S binding domain; Region: Fer4; pfam00037 266117002949 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 266117002950 coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325 266117002951 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 266117002952 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 266117002953 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 266117002954 ATP-sulfurylase; Region: ATPS; cd00517 266117002955 active site 266117002956 HXXH motif; other site 266117002957 flexible loop; other site 266117002958 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 266117002959 ligand-binding site [chemical binding]; other site 266117002960 Shikimate kinase; Region: SKI; pfam01202 266117002961 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117002962 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266117002963 dimer interface [polypeptide binding]; other site 266117002964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117002965 active site 266117002966 metal binding site [ion binding]; metal-binding site 266117002967 glutathione binding site [chemical binding]; other site 266117002968 Helix-turn-helix domain; Region: HTH_17; pfam12728 266117002969 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266117002970 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266117002971 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266117002972 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266117002973 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266117002974 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 266117002975 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 266117002976 putative FMN binding site [chemical binding]; other site 266117002977 FO synthase; Reviewed; Region: fbiC; PRK09234 266117002978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117002979 FeS/SAM binding site; other site 266117002980 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266117002981 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266117002982 active site residue [active] 266117002983 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266117002984 active site residue [active] 266117002985 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266117002986 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266117002987 trimerization site [polypeptide binding]; other site 266117002988 active site 266117002989 argininosuccinate lyase; Provisional; Region: PRK00855 266117002990 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266117002991 active sites [active] 266117002992 tetramer interface [polypeptide binding]; other site 266117002993 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117002994 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266117002995 active site 266117002996 metal binding site [ion binding]; metal-binding site 266117002997 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117002998 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 266117002999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117003000 ABC-ATPase subunit interface; other site 266117003001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117003002 dimer interface [polypeptide binding]; other site 266117003003 conserved gate region; other site 266117003004 ABC-ATPase subunit interface; other site 266117003005 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266117003006 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266117003007 Walker A/P-loop; other site 266117003008 ATP binding site [chemical binding]; other site 266117003009 Q-loop/lid; other site 266117003010 ABC transporter signature motif; other site 266117003011 Walker B; other site 266117003012 D-loop; other site 266117003013 H-loop/switch region; other site 266117003014 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266117003015 catalytic residues [active] 266117003016 ParB-like nuclease domain; Region: ParBc; cl02129 266117003017 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266117003018 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266117003019 GDP-binding site [chemical binding]; other site 266117003020 ACT binding site; other site 266117003021 IMP binding site; other site 266117003022 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266117003023 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266117003024 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117003025 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266117003026 adenylosuccinate lyase; Provisional; Region: PRK07380 266117003027 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 266117003028 tetramer interface [polypeptide binding]; other site 266117003029 active site 266117003030 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 266117003031 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 266117003032 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 266117003033 ATP binding site [chemical binding]; other site 266117003034 active site 266117003035 substrate binding site [chemical binding]; other site 266117003036 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 266117003037 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 266117003038 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266117003039 putative active site [active] 266117003040 catalytic triad [active] 266117003041 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 266117003042 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266117003043 dimerization interface [polypeptide binding]; other site 266117003044 ATP binding site [chemical binding]; other site 266117003045 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266117003046 dimerization interface [polypeptide binding]; other site 266117003047 ATP binding site [chemical binding]; other site 266117003048 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 266117003049 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266117003050 active site 266117003051 tetramer interface [polypeptide binding]; other site 266117003052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117003053 active site 266117003054 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266117003055 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266117003056 dimerization interface [polypeptide binding]; other site 266117003057 putative ATP binding site [chemical binding]; other site 266117003058 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266117003059 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266117003060 active site 266117003061 substrate binding site [chemical binding]; other site 266117003062 cosubstrate binding site; other site 266117003063 catalytic site [active] 266117003064 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266117003065 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266117003066 purine monophosphate binding site [chemical binding]; other site 266117003067 dimer interface [polypeptide binding]; other site 266117003068 putative catalytic residues [active] 266117003069 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266117003070 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266117003071 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266117003072 catalytic residues [active] 266117003073 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 266117003074 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266117003075 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 266117003076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117003077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117003078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117003079 DNA binding residues [nucleotide binding] 266117003080 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266117003081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117003082 non-specific DNA binding site [nucleotide binding]; other site 266117003083 salt bridge; other site 266117003084 sequence-specific DNA binding site [nucleotide binding]; other site 266117003085 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266117003086 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266117003087 putative dimer interface [polypeptide binding]; other site 266117003088 EamA-like transporter family; Region: EamA; pfam00892 266117003089 EamA-like transporter family; Region: EamA; cl17759 266117003090 FOG: CBS domain [General function prediction only]; Region: COG0517 266117003091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 266117003092 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 266117003093 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266117003094 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 266117003095 active site 266117003096 Zn binding site [ion binding]; other site 266117003097 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 266117003098 H+ Antiporter protein; Region: 2A0121; TIGR00900 266117003099 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117003100 Zn2+ binding site [ion binding]; other site 266117003101 Mg2+ binding site [ion binding]; other site 266117003102 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117003103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117003104 metal binding site [ion binding]; metal-binding site 266117003105 active site 266117003106 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266117003107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117003108 Zn2+ binding site [ion binding]; other site 266117003109 Mg2+ binding site [ion binding]; other site 266117003110 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266117003111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117003112 FeS/SAM binding site; other site 266117003113 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266117003114 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266117003115 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 266117003116 transmembrane helices; other site 266117003117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266117003118 FOG: CBS domain [General function prediction only]; Region: COG0517 266117003119 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266117003120 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 266117003121 transmembrane helices; other site 266117003122 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117003123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117003124 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 266117003125 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 266117003126 hydrophobic ligand binding site; other site 266117003127 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 266117003128 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117003129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117003130 DNA-binding site [nucleotide binding]; DNA binding site 266117003131 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266117003132 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 266117003133 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117003134 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266117003135 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266117003136 catalytic triad [active] 266117003137 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266117003138 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266117003139 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266117003140 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266117003141 Cytochrome P450; Region: p450; cl12078 266117003142 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 266117003143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117003144 active site 266117003145 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117003146 active site 266117003147 metal binding site [ion binding]; metal-binding site 266117003148 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 266117003149 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117003150 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266117003151 NAD binding site [chemical binding]; other site 266117003152 catalytic residues [active] 266117003153 acetylornithine deacetylase; Provisional; Region: PRK06837 266117003154 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266117003155 metal binding site [ion binding]; metal-binding site 266117003156 dimer interface [polypeptide binding]; other site 266117003157 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266117003158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266117003159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117003160 catalytic residue [active] 266117003161 recombination factor protein RarA; Reviewed; Region: PRK13342 266117003162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117003163 Walker A motif; other site 266117003164 ATP binding site [chemical binding]; other site 266117003165 Walker B motif; other site 266117003166 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266117003167 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266117003168 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117003169 Uncharacterized conserved protein [Function unknown]; Region: COG3273 266117003170 PhoU domain; Region: PhoU; pfam01895 266117003171 TrkA-C domain; Region: TrkA_C; pfam02080 266117003172 PhoU domain; Region: PhoU; pfam01895 266117003173 TrkA-C domain; Region: TrkA_C; pfam02080 266117003174 Divalent cation transporter; Region: MgtE; cl00786 266117003175 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266117003176 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266117003177 Predicted membrane protein [Function unknown]; Region: COG2259 266117003178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117003179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117003180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266117003181 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266117003182 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 266117003183 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 266117003184 active site 266117003185 dimer interface [polypeptide binding]; other site 266117003186 metal binding site [ion binding]; metal-binding site 266117003187 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 266117003188 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266117003189 putative active site [active] 266117003190 putative substrate binding site [chemical binding]; other site 266117003191 putative FMN binding site [chemical binding]; other site 266117003192 putative catalytic residues [active] 266117003193 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 266117003194 Predicted esterase [General function prediction only]; Region: COG0400 266117003195 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266117003196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003197 Zn binding site [ion binding]; other site 266117003198 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266117003199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003200 Zn binding site [ion binding]; other site 266117003201 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266117003202 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266117003203 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003204 Zn binding site [ion binding]; other site 266117003205 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266117003206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003207 Zn binding site [ion binding]; other site 266117003208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117003209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117003210 putative substrate translocation pore; other site 266117003211 MarR family; Region: MarR; pfam01047 266117003212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117003213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117003214 metal binding site [ion binding]; metal-binding site 266117003215 active site 266117003216 I-site; other site 266117003217 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 266117003218 dimerization interface [polypeptide binding]; other site 266117003219 putative ATP binding site [chemical binding]; other site 266117003220 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 266117003221 glycerol kinase; Provisional; Region: glpK; PRK00047 266117003222 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266117003223 N- and C-terminal domain interface [polypeptide binding]; other site 266117003224 active site 266117003225 MgATP binding site [chemical binding]; other site 266117003226 catalytic site [active] 266117003227 metal binding site [ion binding]; metal-binding site 266117003228 glycerol binding site [chemical binding]; other site 266117003229 homotetramer interface [polypeptide binding]; other site 266117003230 homodimer interface [polypeptide binding]; other site 266117003231 FBP binding site [chemical binding]; other site 266117003232 protein IIAGlc interface [polypeptide binding]; other site 266117003233 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 266117003234 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266117003235 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 266117003236 amphipathic channel; other site 266117003237 Asn-Pro-Ala signature motifs; other site 266117003238 DAK2 domain; Region: Dak2; cl03685 266117003239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 266117003240 active pocket/dimerization site; other site 266117003241 active site 266117003242 phosphorylation site [posttranslational modification] 266117003243 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266117003244 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266117003245 Ferritin-like domain; Region: Ferritin; pfam00210 266117003246 dinuclear metal binding motif [ion binding]; other site 266117003247 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 266117003248 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117003249 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266117003250 Domain of unknown function DUF21; Region: DUF21; pfam01595 266117003251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266117003252 Transporter associated domain; Region: CorC_HlyC; smart01091 266117003253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266117003254 active site 266117003255 L-asparaginase II; Region: Asparaginase_II; pfam06089 266117003256 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 266117003257 PAC2 family; Region: PAC2; pfam09754 266117003258 Protein of unknown function (DUF456); Region: DUF456; pfam04306 266117003259 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 266117003260 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 266117003261 Ligand Binding Site [chemical binding]; other site 266117003262 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266117003263 catalytic triad [active] 266117003264 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266117003265 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266117003266 dimer interface [polypeptide binding]; other site 266117003267 active site 266117003268 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 266117003269 FMN binding site [chemical binding]; other site 266117003270 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 266117003271 dimer interface [polypeptide binding]; other site 266117003272 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 266117003273 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 266117003274 malonyl-CoA binding site [chemical binding]; other site 266117003275 dimer interface [polypeptide binding]; other site 266117003276 active site 266117003277 product binding site; other site 266117003278 Phospholipid methyltransferase; Region: PEMT; cl17370 266117003279 seryl-tRNA synthetase; Provisional; Region: PRK05431 266117003280 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266117003281 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 266117003282 dimer interface [polypeptide binding]; other site 266117003283 active site 266117003284 motif 1; other site 266117003285 motif 2; other site 266117003286 motif 3; other site 266117003287 prolyl-tRNA synthetase; Provisional; Region: PRK08661 266117003288 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 266117003289 dimer interface [polypeptide binding]; other site 266117003290 motif 1; other site 266117003291 active site 266117003292 motif 2; other site 266117003293 motif 3; other site 266117003294 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 266117003295 anticodon binding site; other site 266117003296 zinc-binding site [ion binding]; other site 266117003297 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 266117003298 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 266117003299 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 266117003300 substrate binding site [chemical binding]; other site 266117003301 nucleotide binding site [chemical binding]; other site 266117003302 AAK_AK: Amino Acid Kinase Superfamily (AAK), Aspartokinase (AK); this CD includes the N-terminal catalytic domain of aspartokinase (4-L-aspartate-4-phosphotransferase;). AK is the first enzyme in the biosynthetic pathway of the aspartate family of amino...; Region: AAK_AK; cd04234 266117003303 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 266117003304 aspartate binding site [chemical binding]; other site 266117003305 putative catalytic residues [active] 266117003306 putative nucleotide binding site [chemical binding]; other site 266117003307 homoserine dehydrogenase family protein; Region: PLN02700 266117003308 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266117003309 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 266117003310 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266117003311 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266117003312 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 266117003313 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266117003314 active site 266117003315 PHP Thumb interface [polypeptide binding]; other site 266117003316 metal binding site [ion binding]; metal-binding site 266117003317 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266117003318 generic binding surface I; other site 266117003319 generic binding surface II; other site 266117003320 amino acid transporter; Region: 2A0306; TIGR00909 266117003321 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 266117003322 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 266117003323 active site 266117003324 Zn binding site [ion binding]; other site 266117003325 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266117003326 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 266117003327 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266117003328 dimer interface [polypeptide binding]; other site 266117003329 motif 1; other site 266117003330 active site 266117003331 motif 2; other site 266117003332 motif 3; other site 266117003333 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 266117003334 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 266117003335 histidinol dehydrogenase; Region: hisD; TIGR00069 266117003336 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266117003337 NAD binding site [chemical binding]; other site 266117003338 dimerization interface [polypeptide binding]; other site 266117003339 product binding site; other site 266117003340 substrate binding site [chemical binding]; other site 266117003341 zinc binding site [ion binding]; other site 266117003342 catalytic residues [active] 266117003343 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266117003344 putative active site pocket [active] 266117003345 4-fold oligomerization interface [polypeptide binding]; other site 266117003346 metal binding residues [ion binding]; metal-binding site 266117003347 3-fold/trimer interface [polypeptide binding]; other site 266117003348 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 266117003349 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266117003350 putative active site [active] 266117003351 oxyanion strand; other site 266117003352 catalytic triad [active] 266117003353 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266117003354 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 266117003355 catalytic residues [active] 266117003356 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266117003357 Transglycosylase; Region: Transgly; pfam00912 266117003358 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266117003359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117003360 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 266117003361 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 266117003362 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266117003363 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266117003364 putative NAD(P) binding site [chemical binding]; other site 266117003365 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 266117003366 dimer interface [polypeptide binding]; other site 266117003367 [2Fe-2S] cluster binding site [ion binding]; other site 266117003368 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266117003369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266117003370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117003371 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266117003372 Coenzyme A binding pocket [chemical binding]; other site 266117003373 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117003374 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266117003375 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117003376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117003377 Walker A/P-loop; other site 266117003378 ATP binding site [chemical binding]; other site 266117003379 Q-loop/lid; other site 266117003380 ABC transporter signature motif; other site 266117003381 Walker B; other site 266117003382 D-loop; other site 266117003383 H-loop/switch region; other site 266117003384 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117003385 active site 266117003386 catalytic site [active] 266117003387 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 266117003388 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 266117003389 active site 266117003390 catalytic residues [active] 266117003391 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266117003392 MPT binding site; other site 266117003393 trimer interface [polypeptide binding]; other site 266117003394 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266117003395 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266117003396 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266117003397 interface (dimer of trimers) [polypeptide binding]; other site 266117003398 Substrate-binding/catalytic site; other site 266117003399 Zn-binding sites [ion binding]; other site 266117003400 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266117003401 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266117003402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266117003403 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266117003404 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266117003405 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266117003406 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 266117003407 dimer interface [polypeptide binding]; other site 266117003408 catalytic triad [active] 266117003409 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 266117003410 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 266117003411 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266117003412 putative active site [active] 266117003413 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266117003414 putative active site [active] 266117003415 BON domain; Region: BON; pfam04972 266117003416 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266117003417 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 266117003418 active site 266117003419 substrate binding site [chemical binding]; other site 266117003420 metal binding site [ion binding]; metal-binding site 266117003421 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117003422 active site 266117003423 catalytic site [active] 266117003424 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 266117003425 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266117003426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117003427 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 266117003428 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266117003429 putative DNA binding helix; other site 266117003430 metal binding site 2 [ion binding]; metal-binding site 266117003431 metal binding site 1 [ion binding]; metal-binding site 266117003432 dimer interface [polypeptide binding]; other site 266117003433 structural Zn2+ binding site [ion binding]; other site 266117003434 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266117003435 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266117003436 intersubunit interface [polypeptide binding]; other site 266117003437 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266117003438 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 266117003439 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266117003440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266117003441 ABC-ATPase subunit interface; other site 266117003442 dimer interface [polypeptide binding]; other site 266117003443 putative PBP binding regions; other site 266117003444 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266117003445 metal binding site 2 [ion binding]; metal-binding site 266117003446 putative DNA binding helix; other site 266117003447 metal binding site 1 [ion binding]; metal-binding site 266117003448 structural Zn2+ binding site [ion binding]; other site 266117003449 Rhomboid family; Region: Rhomboid; pfam01694 266117003450 rod shape-determining protein MreC; Provisional; Region: PRK13922 266117003451 endonuclease IV; Provisional; Region: PRK01060 266117003452 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266117003453 AP (apurinic/apyrimidinic) site pocket; other site 266117003454 DNA interaction; other site 266117003455 Metal-binding active site; metal-binding site 266117003456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117003457 non-specific DNA binding site [nucleotide binding]; other site 266117003458 salt bridge; other site 266117003459 sequence-specific DNA binding site [nucleotide binding]; other site 266117003460 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 266117003461 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266117003462 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 266117003463 putative active site [active] 266117003464 Zn binding site [ion binding]; other site 266117003465 Protein of unknown function DUF72; Region: DUF72; pfam01904 266117003466 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 266117003467 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266117003468 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266117003469 substrate binding pocket [chemical binding]; other site 266117003470 active site 266117003471 iron coordination sites [ion binding]; other site 266117003472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117003473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117003474 metal binding site [ion binding]; metal-binding site 266117003475 active site 266117003476 I-site; other site 266117003477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117003478 RDD family; Region: RDD; pfam06271 266117003479 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 266117003480 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266117003481 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 266117003482 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117003483 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117003484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117003485 DNA binding residues [nucleotide binding] 266117003486 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266117003487 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266117003488 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266117003489 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266117003490 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266117003491 Walker A motif; other site 266117003492 ATP binding site [chemical binding]; other site 266117003493 Walker B motif; other site 266117003494 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266117003495 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266117003496 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266117003497 Walker A motif; other site 266117003498 ATP binding site [chemical binding]; other site 266117003499 Walker B motif; other site 266117003500 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266117003501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266117003502 Walker A motif; other site 266117003503 ATP binding site [chemical binding]; other site 266117003504 Walker B motif; other site 266117003505 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 266117003506 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 266117003507 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266117003508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117003509 motif II; other site 266117003510 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 266117003511 homodecamer interface [polypeptide binding]; other site 266117003512 GTP cyclohydrolase I; Provisional; Region: PLN03044 266117003513 active site 266117003514 putative catalytic site residues [active] 266117003515 zinc binding site [ion binding]; other site 266117003516 GTP-CH-I/GFRP interaction surface; other site 266117003517 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266117003518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266117003519 nucleotide binding site [chemical binding]; other site 266117003520 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266117003521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117003522 Walker A/P-loop; other site 266117003523 ATP binding site [chemical binding]; other site 266117003524 Q-loop/lid; other site 266117003525 ABC transporter signature motif; other site 266117003526 Walker B; other site 266117003527 D-loop; other site 266117003528 H-loop/switch region; other site 266117003529 TOBE domain; Region: TOBE_2; pfam08402 266117003530 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266117003531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117003532 dimer interface [polypeptide binding]; other site 266117003533 conserved gate region; other site 266117003534 putative PBP binding loops; other site 266117003535 ABC-ATPase subunit interface; other site 266117003536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266117003537 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266117003538 Iron permease FTR1 family; Region: FTR1; cl00475 266117003539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117003540 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117003541 NAD(P) binding site [chemical binding]; other site 266117003542 active site 266117003543 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266117003544 Sulfatase; Region: Sulfatase; cl17466 266117003545 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266117003546 Ligand binding site; other site 266117003547 Putative Catalytic site; other site 266117003548 DXD motif; other site 266117003549 tartrate dehydrogenase; Provisional; Region: PRK08194 266117003550 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266117003551 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266117003552 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266117003553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117003554 S-adenosylmethionine binding site [chemical binding]; other site 266117003555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117003556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117003557 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 266117003558 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 266117003559 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 266117003560 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266117003561 Ferredoxin [Energy production and conversion]; Region: COG1146 266117003562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266117003563 catalytic loop [active] 266117003564 iron binding site [ion binding]; other site 266117003565 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 266117003566 Ferredoxin [Energy production and conversion]; Region: COG1146 266117003567 4Fe-4S binding domain; Region: Fer4; cl02805 266117003568 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 266117003569 4Fe-4S binding domain; Region: Fer4; cl02805 266117003570 4Fe-4S binding domain; Region: Fer4; pfam00037 266117003571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266117003572 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 266117003573 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 266117003574 Cupin domain; Region: Cupin_2; cl17218 266117003575 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266117003576 Cupin domain; Region: Cupin_2; cl17218 266117003577 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 266117003578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117003579 putative substrate translocation pore; other site 266117003580 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 266117003581 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 266117003582 [4Fe-4S] binding site [ion binding]; other site 266117003583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117003584 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117003585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117003586 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 266117003587 molybdopterin cofactor binding site; other site 266117003588 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 266117003589 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266117003590 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 266117003591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117003592 NAD(P) binding site [chemical binding]; other site 266117003593 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266117003594 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266117003595 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266117003596 putative active site [active] 266117003597 putative CoA binding site [chemical binding]; other site 266117003598 nudix motif; other site 266117003599 metal binding site [ion binding]; metal-binding site 266117003600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117003601 active site 266117003602 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266117003603 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 266117003604 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266117003605 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 266117003606 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266117003607 minor groove reading motif; other site 266117003608 helix-hairpin-helix signature motif; other site 266117003609 substrate binding pocket [chemical binding]; other site 266117003610 active site 266117003611 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 266117003612 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266117003613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117003614 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266117003615 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266117003616 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266117003617 proposed catalytic triad [active] 266117003618 conserved cys residue [active] 266117003619 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266117003620 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266117003621 metal binding site 2 [ion binding]; metal-binding site 266117003622 putative DNA binding helix; other site 266117003623 metal binding site 1 [ion binding]; metal-binding site 266117003624 dimer interface [polypeptide binding]; other site 266117003625 structural Zn2+ binding site [ion binding]; other site 266117003626 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 266117003627 oligomer interface [polypeptide binding]; other site 266117003628 tandem repeat interface [polypeptide binding]; other site 266117003629 active site residues [active] 266117003630 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266117003631 tandem repeat interface [polypeptide binding]; other site 266117003632 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 266117003633 oligomer interface [polypeptide binding]; other site 266117003634 active site residues [active] 266117003635 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117003636 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 266117003637 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266117003638 metal binding site 2 [ion binding]; metal-binding site 266117003639 putative DNA binding helix; other site 266117003640 metal binding site 1 [ion binding]; metal-binding site 266117003641 dimer interface [polypeptide binding]; other site 266117003642 structural Zn2+ binding site [ion binding]; other site 266117003643 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 266117003644 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266117003645 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 266117003646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117003647 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117003648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117003649 DNA binding residues [nucleotide binding] 266117003650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117003651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117003652 metal binding site [ion binding]; metal-binding site 266117003653 active site 266117003654 I-site; other site 266117003655 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266117003656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117003657 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 266117003658 ligand binding site [chemical binding]; other site 266117003659 flexible hinge region; other site 266117003660 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266117003661 putative switch regulator; other site 266117003662 non-specific DNA interactions [nucleotide binding]; other site 266117003663 DNA binding site [nucleotide binding] 266117003664 sequence specific DNA binding site [nucleotide binding]; other site 266117003665 putative cAMP binding site [chemical binding]; other site 266117003666 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117003667 Sulfatase; Region: Sulfatase; cl17466 266117003668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117003669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117003670 NAD(P) binding site [chemical binding]; other site 266117003671 active site 266117003672 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 266117003673 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266117003674 Ligand binding site; other site 266117003675 Putative Catalytic site; other site 266117003676 DXD motif; other site 266117003677 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 266117003678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117003679 NAD binding site [chemical binding]; other site 266117003680 substrate binding site [chemical binding]; other site 266117003681 active site 266117003682 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 266117003683 Bacitracin resistance protein BacA; Region: BacA; pfam02673 266117003684 Chorismate mutase type II; Region: CM_2; smart00830 266117003685 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 266117003686 Prephenate dehydratase; Region: PDT; pfam00800 266117003687 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266117003688 putative L-Phe binding site [chemical binding]; other site 266117003689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 266117003690 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266117003691 DNA-binding site [nucleotide binding]; DNA binding site 266117003692 RNA-binding motif; other site 266117003693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266117003694 catalytic core [active] 266117003695 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266117003696 catalytic residues [active] 266117003697 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 266117003698 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 266117003699 VanW like protein; Region: VanW; pfam04294 266117003700 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266117003701 homotrimer interaction site [polypeptide binding]; other site 266117003702 putative active site [active] 266117003703 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 266117003704 Protease prsW family; Region: PrsW-protease; pfam13367 266117003705 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266117003706 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266117003707 GTP binding site; other site 266117003708 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266117003709 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266117003710 putative active site [active] 266117003711 Homeodomain-like domain; Region: HTH_23; pfam13384 266117003712 Winged helix-turn helix; Region: HTH_29; pfam13551 266117003713 Homeodomain-like domain; Region: HTH_32; pfam13565 266117003714 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266117003715 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266117003716 metal-dependent hydrolase; Provisional; Region: PRK00685 266117003717 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266117003718 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266117003719 nitrilase; Region: PLN02798 266117003720 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266117003721 putative active site [active] 266117003722 catalytic triad [active] 266117003723 dimer interface [polypeptide binding]; other site 266117003724 L-lactate permease; Region: Lactate_perm; cl00701 266117003725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117003726 sequence-specific DNA binding site [nucleotide binding]; other site 266117003727 salt bridge; other site 266117003728 Cupin domain; Region: Cupin_2; pfam07883 266117003729 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 266117003730 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 266117003731 active site 266117003732 PAS domain S-box; Region: sensory_box; TIGR00229 266117003733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117003734 putative active site [active] 266117003735 heme pocket [chemical binding]; other site 266117003736 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266117003737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117003738 putative active site [active] 266117003739 heme pocket [chemical binding]; other site 266117003740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117003741 dimer interface [polypeptide binding]; other site 266117003742 phosphorylation site [posttranslational modification] 266117003743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117003744 ATP binding site [chemical binding]; other site 266117003745 Mg2+ binding site [ion binding]; other site 266117003746 G-X-G motif; other site 266117003747 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266117003748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117003749 active site 266117003750 phosphorylation site [posttranslational modification] 266117003751 intermolecular recognition site; other site 266117003752 dimerization interface [polypeptide binding]; other site 266117003753 Response regulator receiver domain; Region: Response_reg; pfam00072 266117003754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117003755 active site 266117003756 phosphorylation site [posttranslational modification] 266117003757 intermolecular recognition site; other site 266117003758 dimerization interface [polypeptide binding]; other site 266117003759 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266117003760 putative binding surface; other site 266117003761 active site 266117003762 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266117003763 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266117003764 agmatinase; Region: agmatinase; TIGR01230 266117003765 Arginase family; Region: Arginase; cd09989 266117003766 active site 266117003767 Mn binding site [ion binding]; other site 266117003768 oligomer interface [polypeptide binding]; other site 266117003769 Cation transport protein; Region: TrkH; cl17365 266117003770 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 266117003771 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 266117003772 TrkA-N domain; Region: TrkA_N; pfam02254 266117003773 TrkA-C domain; Region: TrkA_C; pfam02080 266117003774 TrkA-N domain; Region: TrkA_N; pfam02254 266117003775 TrkA-C domain; Region: TrkA_C; pfam02080 266117003776 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266117003777 TrkA-N domain; Region: TrkA_N; pfam02254 266117003778 TrkA-C domain; Region: TrkA_C; pfam02080 266117003779 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 266117003780 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 266117003781 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266117003782 CoA binding domain; Region: CoA_binding; pfam02629 266117003783 CoA-ligase; Region: Ligase_CoA; pfam00549 266117003784 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266117003785 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266117003786 CoA-ligase; Region: Ligase_CoA; pfam00549 266117003787 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 266117003788 Protein of unknown function (DUF554); Region: DUF554; pfam04474 266117003789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003790 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266117003791 dimer interface [polypeptide binding]; other site 266117003792 substrate binding site [chemical binding]; other site 266117003793 metal binding site [ion binding]; metal-binding site 266117003794 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 266117003795 MarR family; Region: MarR_2; cl17246 266117003796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266117003797 hypothetical protein; Provisional; Region: PRK07236 266117003798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266117003799 Domain of unknown function DUF59; Region: DUF59; cl00941 266117003800 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266117003801 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266117003802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117003803 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266117003804 dimer interaction site [polypeptide binding]; other site 266117003805 substrate-binding tunnel; other site 266117003806 active site 266117003807 catalytic site [active] 266117003808 substrate binding site [chemical binding]; other site 266117003809 malate dehydrogenase; Provisional; Region: PRK05442 266117003810 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 266117003811 NAD(P) binding site [chemical binding]; other site 266117003812 dimer interface [polypeptide binding]; other site 266117003813 malate binding site [chemical binding]; other site 266117003814 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 266117003815 putative FMN binding site [chemical binding]; other site 266117003816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 266117003817 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 266117003818 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266117003819 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 266117003820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117003821 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 266117003822 catalytic triad [active] 266117003823 putative active site [active] 266117003824 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266117003825 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266117003826 isocitrate dehydrogenase; Validated; Region: PRK06451 266117003827 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266117003828 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266117003829 Predicted membrane protein [Function unknown]; Region: COG2246 266117003830 GtrA-like protein; Region: GtrA; pfam04138 266117003831 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266117003832 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266117003833 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266117003834 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266117003835 active site 266117003836 dimer interface [polypeptide binding]; other site 266117003837 motif 1; other site 266117003838 motif 2; other site 266117003839 motif 3; other site 266117003840 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266117003841 anticodon binding site; other site 266117003842 translation initiation factor IF-3; Region: infC; TIGR00168 266117003843 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266117003844 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266117003845 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266117003846 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266117003847 23S rRNA binding site [nucleotide binding]; other site 266117003848 L21 binding site [polypeptide binding]; other site 266117003849 L13 binding site [polypeptide binding]; other site 266117003850 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266117003851 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266117003852 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266117003853 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266117003854 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266117003855 dimer interface [polypeptide binding]; other site 266117003856 motif 1; other site 266117003857 active site 266117003858 motif 2; other site 266117003859 motif 3; other site 266117003860 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266117003861 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266117003862 putative tRNA-binding site [nucleotide binding]; other site 266117003863 B3/4 domain; Region: B3_4; pfam03483 266117003864 tRNA synthetase B5 domain; Region: B5; smart00874 266117003865 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266117003866 dimer interface [polypeptide binding]; other site 266117003867 motif 1; other site 266117003868 motif 3; other site 266117003869 motif 2; other site 266117003870 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 266117003871 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266117003872 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117003873 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266117003874 active site 266117003875 DNA binding site [nucleotide binding] 266117003876 Transglycosylase; Region: Transgly; pfam00912 266117003877 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266117003878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117003879 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266117003880 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266117003881 active site 266117003882 HIGH motif; other site 266117003883 dimer interface [polypeptide binding]; other site 266117003884 KMSKS motif; other site 266117003885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117003886 RNA binding surface [nucleotide binding]; other site 266117003887 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266117003888 putative active site [active] 266117003889 putative metal binding site [ion binding]; other site 266117003890 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266117003891 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 266117003892 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 266117003893 P loop; other site 266117003894 Nucleotide binding site [chemical binding]; other site 266117003895 DTAP/Switch II; other site 266117003896 Switch I; other site 266117003897 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 266117003898 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 266117003899 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 266117003900 active site 266117003901 multimer interface [polypeptide binding]; other site 266117003902 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 266117003903 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 266117003904 predicted active site [active] 266117003905 catalytic triad [active] 266117003906 hypothetical protein; Validated; Region: PRK00110 266117003907 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 266117003908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117003909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117003910 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 266117003911 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 266117003912 active site 266117003913 putative DNA-binding cleft [nucleotide binding]; other site 266117003914 dimer interface [polypeptide binding]; other site 266117003915 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266117003916 RuvA N terminal domain; Region: RuvA_N; pfam01330 266117003917 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 266117003918 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266117003919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117003920 Walker A motif; other site 266117003921 ATP binding site [chemical binding]; other site 266117003922 Walker B motif; other site 266117003923 arginine finger; other site 266117003924 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266117003925 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266117003926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 266117003927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117003928 putative metal binding site [ion binding]; other site 266117003929 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266117003930 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 266117003931 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266117003932 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 266117003933 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266117003934 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 266117003935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117003936 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266117003937 ligand binding site [chemical binding]; other site 266117003938 flexible hinge region; other site 266117003939 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 266117003940 Thermus thermophilus Tt1561 and related proteins, metallophosphatase domain; Region: MPP_Tt1561; cd07388 266117003941 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 266117003942 protein-export membrane protein SecD; Region: secD; TIGR01129 266117003943 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 266117003944 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 266117003945 Protein export membrane protein; Region: SecD_SecF; pfam02355 266117003946 Uncharacterized conserved protein [Function unknown]; Region: COG3937 266117003947 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 266117003948 ABC1 family; Region: ABC1; cl17513 266117003949 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266117003950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117003951 Zn2+ binding site [ion binding]; other site 266117003952 Mg2+ binding site [ion binding]; other site 266117003953 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266117003954 synthetase active site [active] 266117003955 NTP binding site [chemical binding]; other site 266117003956 metal binding site [ion binding]; metal-binding site 266117003957 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266117003958 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266117003959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117003960 histidyl-tRNA synthetase; Region: hisS; TIGR00442 266117003961 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266117003962 dimer interface [polypeptide binding]; other site 266117003963 motif 1; other site 266117003964 active site 266117003965 motif 2; other site 266117003966 motif 3; other site 266117003967 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266117003968 anticodon binding site; other site 266117003969 NAD-dependent deacetylase; Provisional; Region: PRK00481 266117003970 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 266117003971 NAD+ binding site [chemical binding]; other site 266117003972 substrate binding site [chemical binding]; other site 266117003973 Zn binding site [ion binding]; other site 266117003974 Ion transport protein; Region: Ion_trans; pfam00520 266117003975 Ion channel; Region: Ion_trans_2; pfam07885 266117003976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266117003977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117003978 active site 266117003979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117003980 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 266117003981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117003982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117003983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117003984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117003985 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266117003986 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266117003987 NodB motif; other site 266117003988 active site 266117003989 catalytic site [active] 266117003990 metal binding site [ion binding]; metal-binding site 266117003991 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117003992 active site 266117003993 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266117003994 carboxylate-amine ligase; Provisional; Region: PRK13517 266117003995 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266117003996 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266117003997 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266117003998 dimer interface [polypeptide binding]; other site 266117003999 anticodon binding site; other site 266117004000 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266117004001 homodimer interface [polypeptide binding]; other site 266117004002 motif 1; other site 266117004003 active site 266117004004 motif 2; other site 266117004005 GAD domain; Region: GAD; pfam02938 266117004006 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266117004007 active site 266117004008 motif 3; other site 266117004009 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266117004010 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266117004011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117004012 catalytic residue [active] 266117004013 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266117004014 trimerization site [polypeptide binding]; other site 266117004015 active site 266117004016 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266117004017 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266117004018 Ligand Binding Site [chemical binding]; other site 266117004019 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 266117004020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117004021 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117004022 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266117004023 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266117004024 motif 1; other site 266117004025 active site 266117004026 motif 2; other site 266117004027 motif 3; other site 266117004028 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266117004029 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 266117004030 YceG-like family; Region: YceG; pfam02618 266117004031 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266117004032 dimerization interface [polypeptide binding]; other site 266117004033 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 266117004034 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266117004035 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266117004036 shikimate binding site; other site 266117004037 NAD(P) binding site [chemical binding]; other site 266117004038 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266117004039 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266117004040 substrate binding site [chemical binding]; other site 266117004041 hexamer interface [polypeptide binding]; other site 266117004042 metal binding site [ion binding]; metal-binding site 266117004043 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 266117004044 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266117004045 catalytic motif [active] 266117004046 Zn binding site [ion binding]; other site 266117004047 RibD C-terminal domain; Region: RibD_C; cl17279 266117004048 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266117004049 Lumazine binding domain; Region: Lum_binding; pfam00677 266117004050 Lumazine binding domain; Region: Lum_binding; pfam00677 266117004051 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 266117004052 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266117004053 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266117004054 dimerization interface [polypeptide binding]; other site 266117004055 active site 266117004056 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266117004057 homopentamer interface [polypeptide binding]; other site 266117004058 active site 266117004059 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266117004060 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 266117004061 DAK2 domain; Region: Dak2; pfam02734 266117004062 EDD domain protein, DegV family; Region: DegV; TIGR00762 266117004063 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 266117004064 Y-family of DNA polymerases; Region: PolY; cl12025 266117004065 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266117004066 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266117004067 ssDNA binding site; other site 266117004068 generic binding surface II; other site 266117004069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266117004070 ATP binding site [chemical binding]; other site 266117004071 putative Mg++ binding site [ion binding]; other site 266117004072 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266117004073 nucleotide binding region [chemical binding]; other site 266117004074 ATP-binding site [chemical binding]; other site 266117004075 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 266117004076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117004077 S-adenosylmethionine binding site [chemical binding]; other site 266117004078 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266117004079 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266117004080 active site 266117004081 (T/H)XGH motif; other site 266117004082 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266117004083 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 266117004084 putative phosphate acyltransferase; Provisional; Region: PRK05331 266117004085 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266117004086 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266117004087 dimer interface [polypeptide binding]; other site 266117004088 active site 266117004089 CoA binding pocket [chemical binding]; other site 266117004090 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266117004091 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266117004092 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266117004093 homotetramer interface [polypeptide binding]; other site 266117004094 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266117004095 NAD(P) binding site [chemical binding]; other site 266117004096 homodimer interface [polypeptide binding]; other site 266117004097 active site 266117004098 acyl carrier protein; Provisional; Region: acpP; PRK00982 266117004099 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266117004100 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266117004101 dimer interface [polypeptide binding]; other site 266117004102 active site 266117004103 ribonuclease III; Reviewed; Region: rnc; PRK00102 266117004104 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266117004105 dimerization interface [polypeptide binding]; other site 266117004106 active site 266117004107 metal binding site [ion binding]; metal-binding site 266117004108 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266117004109 dsRNA binding site [nucleotide binding]; other site 266117004110 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266117004111 Walker A/P-loop; other site 266117004112 ATP binding site [chemical binding]; other site 266117004113 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 266117004114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117004115 ABC transporter signature motif; other site 266117004116 Walker B; other site 266117004117 D-loop; other site 266117004118 H-loop/switch region; other site 266117004119 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 266117004120 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 266117004121 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266117004122 P loop; other site 266117004123 GTP binding site [chemical binding]; other site 266117004124 signal recognition particle protein; Provisional; Region: PRK10867 266117004125 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266117004126 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266117004127 P loop; other site 266117004128 GTP binding site [chemical binding]; other site 266117004129 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266117004130 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 266117004131 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 266117004132 KH domain; Region: KH_4; pfam13083 266117004133 G-X-X-G motif; other site 266117004134 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266117004135 RimM N-terminal domain; Region: RimM; pfam01782 266117004136 PRC-barrel domain; Region: PRC; pfam05239 266117004137 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 266117004138 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266117004139 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266117004140 RNA/DNA hybrid binding site [nucleotide binding]; other site 266117004141 active site 266117004142 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266117004143 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266117004144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117004145 Walker A motif; other site 266117004146 ATP binding site [chemical binding]; other site 266117004147 Walker B motif; other site 266117004148 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266117004149 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266117004150 DNA protecting protein DprA; Region: dprA; TIGR00732 266117004151 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 266117004152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117004153 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117004154 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266117004155 rRNA interaction site [nucleotide binding]; other site 266117004156 S8 interaction site; other site 266117004157 putative laminin-1 binding site; other site 266117004158 elongation factor Ts; Reviewed; Region: tsf; PRK12332 266117004159 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 266117004160 Elongation factor TS; Region: EF_TS; pfam00889 266117004161 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266117004162 putative nucleotide binding site [chemical binding]; other site 266117004163 uridine monophosphate binding site [chemical binding]; other site 266117004164 homohexameric interface [polypeptide binding]; other site 266117004165 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266117004166 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266117004167 hinge region; other site 266117004168 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 266117004169 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 266117004170 catalytic residue [active] 266117004171 putative FPP diphosphate binding site; other site 266117004172 putative FPP binding hydrophobic cleft; other site 266117004173 dimer interface [polypeptide binding]; other site 266117004174 putative IPP diphosphate binding site; other site 266117004175 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 266117004176 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266117004177 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266117004178 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266117004179 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266117004180 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266117004181 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 266117004182 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266117004183 active site 266117004184 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266117004185 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266117004186 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266117004187 GcpE protein; Region: GcpE; pfam04551 266117004188 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266117004189 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 266117004190 putative hydrophobic ligand binding site [chemical binding]; other site 266117004191 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266117004192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 266117004193 Sm and related proteins; Region: Sm_like; cl00259 266117004194 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 266117004195 putative oligomer interface [polypeptide binding]; other site 266117004196 putative RNA binding site [nucleotide binding]; other site 266117004197 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 266117004198 NusA N-terminal domain; Region: NusA_N; pfam08529 266117004199 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266117004200 RNA binding site [nucleotide binding]; other site 266117004201 homodimer interface [polypeptide binding]; other site 266117004202 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266117004203 G-X-X-G motif; other site 266117004204 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266117004205 G-X-X-G motif; other site 266117004206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266117004207 translation initiation factor IF-2; Region: IF-2; TIGR00487 266117004208 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266117004209 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266117004210 G1 box; other site 266117004211 putative GEF interaction site [polypeptide binding]; other site 266117004212 GTP/Mg2+ binding site [chemical binding]; other site 266117004213 Switch I region; other site 266117004214 G2 box; other site 266117004215 G3 box; other site 266117004216 Switch II region; other site 266117004217 G4 box; other site 266117004218 G5 box; other site 266117004219 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266117004220 Translation-initiation factor 2; Region: IF-2; pfam11987 266117004221 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266117004222 Protein of unknown function (DUF503); Region: DUF503; pfam04456 266117004223 Ribosome-binding factor A; Region: RBFA; pfam02033 266117004224 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 266117004225 DHH family; Region: DHH; pfam01368 266117004226 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 266117004227 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266117004228 RNA binding site [nucleotide binding]; other site 266117004229 active site 266117004230 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 266117004231 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266117004232 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266117004233 active site 266117004234 Riboflavin kinase; Region: Flavokinase; pfam01687 266117004235 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266117004236 16S/18S rRNA binding site [nucleotide binding]; other site 266117004237 S13e-L30e interaction site [polypeptide binding]; other site 266117004238 25S rRNA binding site [nucleotide binding]; other site 266117004239 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266117004240 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266117004241 RNase E interface [polypeptide binding]; other site 266117004242 trimer interface [polypeptide binding]; other site 266117004243 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266117004244 RNase E interface [polypeptide binding]; other site 266117004245 trimer interface [polypeptide binding]; other site 266117004246 active site 266117004247 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266117004248 putative nucleic acid binding region [nucleotide binding]; other site 266117004249 G-X-X-G motif; other site 266117004250 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266117004251 RNA binding site [nucleotide binding]; other site 266117004252 domain interface; other site 266117004253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266117004254 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266117004255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266117004256 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266117004257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117004258 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266117004259 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266117004260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266117004261 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266117004262 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 266117004263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117004264 non-specific DNA binding site [nucleotide binding]; other site 266117004265 salt bridge; other site 266117004266 sequence-specific DNA binding site [nucleotide binding]; other site 266117004267 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 266117004268 recombinase A; Provisional; Region: recA; PRK09354 266117004269 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266117004270 hexamer interface [polypeptide binding]; other site 266117004271 Walker A motif; other site 266117004272 ATP binding site [chemical binding]; other site 266117004273 Walker B motif; other site 266117004274 recombination regulator RecX; Reviewed; Region: recX; PRK00117 266117004275 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 266117004276 KH domain; Region: KH_1; pfam00013 266117004277 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 266117004278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117004279 Zn2+ binding site [ion binding]; other site 266117004280 Mg2+ binding site [ion binding]; other site 266117004281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117004282 ATP binding site [chemical binding]; other site 266117004283 Mg2+ binding site [ion binding]; other site 266117004284 G-X-G motif; other site 266117004285 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266117004286 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 266117004287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117004288 FeS/SAM binding site; other site 266117004289 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 266117004290 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266117004291 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266117004292 HflX GTPase family; Region: HflX; cd01878 266117004293 G1 box; other site 266117004294 GTP/Mg2+ binding site [chemical binding]; other site 266117004295 Switch I region; other site 266117004296 G2 box; other site 266117004297 G3 box; other site 266117004298 Switch II region; other site 266117004299 G4 box; other site 266117004300 G5 box; other site 266117004301 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 266117004302 RibD C-terminal domain; Region: RibD_C; cl17279 266117004303 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266117004304 active site 266117004305 DNA binding site [nucleotide binding] 266117004306 Int/Topo IB signature motif; other site 266117004307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117004308 active site 266117004309 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266117004310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266117004311 DNA binding residues [nucleotide binding] 266117004312 dimer interface [polypeptide binding]; other site 266117004313 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 266117004314 Double zinc ribbon; Region: DZR; pfam12773 266117004315 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266117004316 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266117004317 phosphopeptide binding site; other site 266117004318 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266117004319 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 266117004320 active site 266117004321 Substrate binding site; other site 266117004322 Mg++ binding site; other site 266117004323 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 266117004324 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 266117004325 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 266117004326 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 266117004327 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266117004328 GTP/Mg2+ binding site [chemical binding]; other site 266117004329 Switch I region; other site 266117004330 G2 box; other site 266117004331 Switch II region; other site 266117004332 G3 box; other site 266117004333 G4 box; other site 266117004334 G5 box; other site 266117004335 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266117004336 G1 box; other site 266117004337 GTP/Mg2+ binding site [chemical binding]; other site 266117004338 G2 box; other site 266117004339 Switch I region; other site 266117004340 G3 box; other site 266117004341 Switch II region; other site 266117004342 G4 box; other site 266117004343 G5 box; other site 266117004344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266117004345 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266117004346 putative acyl-acceptor binding pocket; other site 266117004347 cytidylate kinase; Provisional; Region: cmk; PRK00023 266117004348 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266117004349 CMP-binding site; other site 266117004350 The sites determining sugar specificity; other site 266117004351 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 266117004352 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266117004353 hinge; other site 266117004354 active site 266117004355 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266117004356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117004357 RNA binding surface [nucleotide binding]; other site 266117004358 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 266117004359 active site 266117004360 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 266117004361 ScpA/B protein; Region: ScpA_ScpB; cl00598 266117004362 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266117004363 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266117004364 hexamer interface [polypeptide binding]; other site 266117004365 ligand binding site [chemical binding]; other site 266117004366 putative active site [active] 266117004367 NAD(P) binding site [chemical binding]; other site 266117004368 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 266117004369 CTP synthetase; Validated; Region: pyrG; PRK05380 266117004370 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266117004371 Catalytic site [active] 266117004372 active site 266117004373 UTP binding site [chemical binding]; other site 266117004374 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266117004375 active site 266117004376 putative oxyanion hole; other site 266117004377 catalytic triad [active] 266117004378 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 266117004379 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 266117004380 Thiamine pyrophosphokinase; Region: TPK; cl08415 266117004381 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266117004382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117004383 Walker A/P-loop; other site 266117004384 ATP binding site [chemical binding]; other site 266117004385 Q-loop/lid; other site 266117004386 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266117004387 ABC transporter signature motif; other site 266117004388 Walker B; other site 266117004389 D-loop; other site 266117004390 H-loop/switch region; other site 266117004391 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 266117004392 ATP-NAD kinase; Region: NAD_kinase; pfam01513 266117004393 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117004394 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 266117004395 RNA binding surface [nucleotide binding]; other site 266117004396 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 266117004397 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266117004398 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266117004399 substrate binding pocket [chemical binding]; other site 266117004400 chain length determination region; other site 266117004401 substrate-Mg2+ binding site; other site 266117004402 catalytic residues [active] 266117004403 aspartate-rich region 1; other site 266117004404 active site lid residues [active] 266117004405 aspartate-rich region 2; other site 266117004406 transcription antitermination factor NusB; Region: nusB; TIGR01951 266117004407 putative RNA binding site [nucleotide binding]; other site 266117004408 elongation factor P; Validated; Region: PRK00529 266117004409 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266117004410 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266117004411 RNA binding site [nucleotide binding]; other site 266117004412 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266117004413 RNA binding site [nucleotide binding]; other site 266117004414 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266117004415 active site 266117004416 dimer interface [polypeptide binding]; other site 266117004417 metal binding site [ion binding]; metal-binding site 266117004418 shikimate kinase; Reviewed; Region: aroK; PRK00131 266117004419 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266117004420 ADP binding site [chemical binding]; other site 266117004421 magnesium binding site [ion binding]; other site 266117004422 putative shikimate binding site; other site 266117004423 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266117004424 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266117004425 Tetramer interface [polypeptide binding]; other site 266117004426 active site 266117004427 FMN-binding site [chemical binding]; other site 266117004428 Pilus assembly protein, PilO; Region: PilO; cl01234 266117004429 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 266117004430 Cell division protein FtsA; Region: FtsA; cl17206 266117004431 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266117004432 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266117004433 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266117004434 putative active site [active] 266117004435 substrate binding site [chemical binding]; other site 266117004436 putative cosubstrate binding site; other site 266117004437 catalytic site [active] 266117004438 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266117004439 substrate binding site [chemical binding]; other site 266117004440 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266117004441 active site 266117004442 catalytic residues [active] 266117004443 metal binding site [ion binding]; metal-binding site 266117004444 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 266117004445 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266117004446 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266117004447 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266117004448 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266117004449 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266117004450 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266117004451 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266117004452 Guanylate kinase; Region: Guanylate_kin; pfam00625 266117004453 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266117004454 catalytic site [active] 266117004455 G-X2-G-X-G-K; other site 266117004456 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 266117004457 heterodimer interface [polypeptide binding]; other site 266117004458 active site 266117004459 FMN binding site [chemical binding]; other site 266117004460 homodimer interface [polypeptide binding]; other site 266117004461 substrate binding site [chemical binding]; other site 266117004462 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 266117004463 FAD binding pocket [chemical binding]; other site 266117004464 FAD binding motif [chemical binding]; other site 266117004465 phosphate binding motif [ion binding]; other site 266117004466 beta-alpha-beta structure motif; other site 266117004467 NAD binding pocket [chemical binding]; other site 266117004468 Iron coordination center [ion binding]; other site 266117004469 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266117004470 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117004471 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266117004472 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266117004473 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117004474 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117004475 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266117004476 IMP binding site; other site 266117004477 dimer interface [polypeptide binding]; other site 266117004478 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266117004479 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266117004480 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266117004481 catalytic site [active] 266117004482 subunit interface [polypeptide binding]; other site 266117004483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117004484 dihydroorotase; Validated; Region: pyrC; PRK09357 266117004485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117004486 active site 266117004487 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266117004488 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266117004489 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266117004490 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 266117004491 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117004492 active site 266117004493 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266117004494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117004495 RNA binding surface [nucleotide binding]; other site 266117004496 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266117004497 active site 266117004498 DivIVA domain; Region: DivI1A_domain; TIGR03544 266117004499 DivIVA protein; Region: DivIVA; pfam05103 266117004500 YGGT family; Region: YGGT; pfam02325 266117004501 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266117004502 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266117004503 Protein of unknown function (DUF552); Region: DUF552; pfam04472 266117004504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266117004505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266117004506 catalytic residue [active] 266117004507 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266117004508 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 266117004509 cell division protein FtsZ; Validated; Region: PRK09330 266117004510 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266117004511 nucleotide binding site [chemical binding]; other site 266117004512 SulA interaction site; other site 266117004513 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 266117004514 Cell division protein FtsA; Region: FtsA; smart00842 266117004515 Cell division protein FtsA; Region: FtsA; pfam14450 266117004516 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266117004517 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266117004518 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266117004519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117004520 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266117004521 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266117004522 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266117004523 homodimer interface [polypeptide binding]; other site 266117004524 active site 266117004525 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 266117004526 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 266117004527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117004528 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266117004529 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266117004530 Mg++ binding site [ion binding]; other site 266117004531 putative catalytic motif [active] 266117004532 putative substrate binding site [chemical binding]; other site 266117004533 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 266117004534 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266117004535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117004536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266117004537 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 266117004538 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266117004539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117004540 MraW methylase family; Region: Methyltransf_5; cl17771 266117004541 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 266117004542 MraZ protein; Region: MraZ; pfam02381 266117004543 cell division protein MraZ; Reviewed; Region: PRK00326 266117004544 MraZ protein; Region: MraZ; pfam02381 266117004545 DNA primase, catalytic core; Region: dnaG; TIGR01391 266117004546 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266117004547 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266117004548 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266117004549 active site 266117004550 metal binding site [ion binding]; metal-binding site 266117004551 interdomain interaction site; other site 266117004552 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266117004553 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266117004554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117004555 Zn2+ binding site [ion binding]; other site 266117004556 Mg2+ binding site [ion binding]; other site 266117004557 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266117004558 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266117004559 Recombination protein O N terminal; Region: RecO_N; pfam11967 266117004560 Recombination protein O C terminal; Region: RecO_C; pfam02565 266117004561 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266117004562 intersubunit interface [polypeptide binding]; other site 266117004563 active site 266117004564 catalytic residue [active] 266117004565 GTPase Era; Reviewed; Region: era; PRK00089 266117004566 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266117004567 G1 box; other site 266117004568 GTP/Mg2+ binding site [chemical binding]; other site 266117004569 Switch I region; other site 266117004570 G2 box; other site 266117004571 Switch II region; other site 266117004572 G3 box; other site 266117004573 G4 box; other site 266117004574 G5 box; other site 266117004575 KH domain; Region: KH_2; pfam07650 266117004576 G-X-X-G motif; other site 266117004577 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266117004578 active site 266117004579 catalytic motif [active] 266117004580 Zn binding site [ion binding]; other site 266117004581 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 266117004582 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266117004583 active site 266117004584 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 266117004585 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 266117004586 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 266117004587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117004588 Zn2+ binding site [ion binding]; other site 266117004589 Mg2+ binding site [ion binding]; other site 266117004590 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266117004591 PhoH-like protein; Region: PhoH; pfam02562 266117004592 Yqey-like protein; Region: YqeY; cl17540 266117004593 RNA methyltransferase, RsmE family; Region: TIGR00046 266117004594 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 266117004595 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 266117004596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266117004597 HSP70 interaction site [polypeptide binding]; other site 266117004598 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266117004599 substrate binding site [polypeptide binding]; other site 266117004600 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266117004601 Zn binding sites [ion binding]; other site 266117004602 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266117004603 dimer interface [polypeptide binding]; other site 266117004604 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266117004605 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 266117004606 GTP-binding protein LepA; Provisional; Region: PRK05433 266117004607 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266117004608 G1 box; other site 266117004609 putative GEF interaction site [polypeptide binding]; other site 266117004610 GTP/Mg2+ binding site [chemical binding]; other site 266117004611 Switch I region; other site 266117004612 G2 box; other site 266117004613 G3 box; other site 266117004614 Switch II region; other site 266117004615 G4 box; other site 266117004616 G5 box; other site 266117004617 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266117004618 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266117004619 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266117004620 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 266117004621 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 266117004622 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266117004623 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 266117004624 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266117004625 Competence protein; Region: Competence; pfam03772 266117004626 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 266117004627 Helix-hairpin-helix motif; Region: HHH; pfam00633 266117004628 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266117004629 Oligomerisation domain; Region: Oligomerisation; pfam02410 266117004630 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 266117004631 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266117004632 active site 266117004633 (T/H)XGH motif; other site 266117004634 GTPase CgtA; Reviewed; Region: obgE; PRK12297 266117004635 GTP1/OBG; Region: GTP1_OBG; pfam01018 266117004636 Obg GTPase; Region: Obg; cd01898 266117004637 G1 box; other site 266117004638 GTP/Mg2+ binding site [chemical binding]; other site 266117004639 Switch I region; other site 266117004640 G2 box; other site 266117004641 G3 box; other site 266117004642 Switch II region; other site 266117004643 G4 box; other site 266117004644 G5 box; other site 266117004645 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 266117004646 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266117004647 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 266117004648 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 266117004649 rod shape-determining protein MreC; Provisional; Region: PRK13922 266117004650 rod shape-determining protein MreC; Region: MreC; pfam04085 266117004651 rod shape-determining protein MreB; Provisional; Region: PRK13927 266117004652 MreB and similar proteins; Region: MreB_like; cd10225 266117004653 nucleotide binding site [chemical binding]; other site 266117004654 Mg binding site [ion binding]; other site 266117004655 putative protofilament interaction site [polypeptide binding]; other site 266117004656 RodZ interaction site [polypeptide binding]; other site 266117004657 hypothetical protein; Reviewed; Region: PRK00024 266117004658 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266117004659 MPN+ (JAMM) motif; other site 266117004660 Zinc-binding site [ion binding]; other site 266117004661 Maf-like protein; Region: Maf; pfam02545 266117004662 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266117004663 active site 266117004664 dimer interface [polypeptide binding]; other site 266117004665 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266117004666 active site 266117004667 multimer interface [polypeptide binding]; other site 266117004668 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 266117004669 Double zinc ribbon; Region: DZR; pfam12773 266117004670 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 266117004671 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117004672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266117004673 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266117004674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266117004675 active site 266117004676 HIGH motif; other site 266117004677 nucleotide binding site [chemical binding]; other site 266117004678 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266117004679 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266117004680 active site 266117004681 KMSKS motif; other site 266117004682 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266117004683 tRNA binding surface [nucleotide binding]; other site 266117004684 anticodon binding site; other site 266117004685 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266117004686 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266117004687 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266117004688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117004689 Walker A motif; other site 266117004690 ATP binding site [chemical binding]; other site 266117004691 Walker B motif; other site 266117004692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266117004693 Clp protease; Region: CLP_protease; pfam00574 266117004694 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266117004695 oligomer interface [polypeptide binding]; other site 266117004696 active site residues [active] 266117004697 trigger factor; Region: tig; TIGR00115 266117004698 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266117004699 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266117004700 putative cation:proton antiport protein; Provisional; Region: PRK10669 266117004701 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266117004702 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266117004703 TrkA-N domain; Region: TrkA_N; pfam02254 266117004704 TrkA-C domain; Region: TrkA_C; pfam02080 266117004705 Transcriptional regulator [Transcription]; Region: LytR; COG1316 266117004706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117004707 putative substrate translocation pore; other site 266117004708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117004709 benzoylformate decarboxylase; Reviewed; Region: PRK07092 266117004710 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117004711 PYR/PP interface [polypeptide binding]; other site 266117004712 dimer interface [polypeptide binding]; other site 266117004713 TPP binding site [chemical binding]; other site 266117004714 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117004715 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266117004716 TPP-binding site [chemical binding]; other site 266117004717 dimer interface [polypeptide binding]; other site 266117004718 Cupin domain; Region: Cupin_2; cl17218 266117004719 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266117004720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117004721 metal binding site [ion binding]; metal-binding site 266117004722 active site 266117004723 I-site; other site 266117004724 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117004725 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266117004726 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266117004727 active site 266117004728 dimerization interface [polypeptide binding]; other site 266117004729 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266117004730 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266117004731 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117004732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117004733 Walker A/P-loop; other site 266117004734 ATP binding site [chemical binding]; other site 266117004735 Q-loop/lid; other site 266117004736 ABC transporter signature motif; other site 266117004737 Walker B; other site 266117004738 D-loop; other site 266117004739 H-loop/switch region; other site 266117004740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117004741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117004742 active site 266117004743 phosphorylation site [posttranslational modification] 266117004744 intermolecular recognition site; other site 266117004745 dimerization interface [polypeptide binding]; other site 266117004746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117004747 DNA binding residues [nucleotide binding] 266117004748 dimerization interface [polypeptide binding]; other site 266117004749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117004750 Histidine kinase; Region: HisKA_3; pfam07730 266117004751 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266117004752 Mg2+ binding site [ion binding]; other site 266117004753 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266117004754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117004755 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266117004756 dimerization interface [polypeptide binding]; other site 266117004757 substrate binding pocket [chemical binding]; other site 266117004758 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266117004759 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 266117004760 Walker A/P-loop; other site 266117004761 ATP binding site [chemical binding]; other site 266117004762 Q-loop/lid; other site 266117004763 ABC transporter signature motif; other site 266117004764 Walker B; other site 266117004765 D-loop; other site 266117004766 H-loop/switch region; other site 266117004767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266117004768 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 266117004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117004770 dimer interface [polypeptide binding]; other site 266117004771 conserved gate region; other site 266117004772 ABC-ATPase subunit interface; other site 266117004773 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266117004774 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117004775 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266117004776 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 266117004777 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117004778 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266117004779 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266117004780 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266117004781 active site 266117004782 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266117004783 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266117004784 [2Fe-2S] cluster binding site [ion binding]; other site 266117004785 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266117004786 alpha subunit interface [polypeptide binding]; other site 266117004787 active site 266117004788 substrate binding site [chemical binding]; other site 266117004789 Fe binding site [ion binding]; other site 266117004790 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117004791 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 266117004792 NAD(P) binding site [chemical binding]; other site 266117004793 catalytic residues [active] 266117004794 catalytic residues [active] 266117004795 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 266117004796 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117004797 putative NAD(P) binding site [chemical binding]; other site 266117004798 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 266117004799 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266117004800 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266117004801 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266117004802 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117004803 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 266117004804 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266117004805 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266117004806 homodimer interface [polypeptide binding]; other site 266117004807 NADP binding site [chemical binding]; other site 266117004808 substrate binding site [chemical binding]; other site 266117004809 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 266117004810 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266117004811 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266117004812 Potassium binding sites [ion binding]; other site 266117004813 Cesium cation binding sites [ion binding]; other site 266117004814 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266117004815 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 266117004816 acyl-activating enzyme (AAE) consensus motif; other site 266117004817 putative AMP binding site [chemical binding]; other site 266117004818 putative active site [active] 266117004819 putative CoA binding site [chemical binding]; other site 266117004820 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266117004821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117004822 active site 266117004823 motif I; other site 266117004824 motif II; other site 266117004825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117004826 motif II; other site 266117004827 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266117004828 active site 266117004829 catalytic residues [active] 266117004830 metal binding site [ion binding]; metal-binding site 266117004831 homodimer binding site [polypeptide binding]; other site 266117004832 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266117004833 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117004834 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117004835 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266117004836 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266117004837 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266117004838 carboxyltransferase (CT) interaction site; other site 266117004839 biotinylation site [posttranslational modification]; other site 266117004840 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266117004841 hypothetical protein; Provisional; Region: PRK08296 266117004842 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266117004843 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 266117004844 FAD binding site [chemical binding]; other site 266117004845 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 266117004846 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266117004847 TAP-like protein; Region: Abhydrolase_4; pfam08386 266117004848 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 266117004849 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266117004850 tetramer interface [polypeptide binding]; other site 266117004851 active site 266117004852 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 266117004853 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266117004854 heterodimer interface [polypeptide binding]; other site 266117004855 active site 266117004856 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266117004857 heterodimer interface [polypeptide binding]; other site 266117004858 multimer interface [polypeptide binding]; other site 266117004859 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266117004860 active site 266117004861 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266117004862 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117004863 dimer interface [polypeptide binding]; other site 266117004864 active site 266117004865 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 266117004866 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266117004867 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266117004868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117004869 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266117004870 dimerization interface [polypeptide binding]; other site 266117004871 substrate binding pocket [chemical binding]; other site 266117004872 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266117004873 substrate binding site [chemical binding]; other site 266117004874 THF binding site; other site 266117004875 zinc-binding site [ion binding]; other site 266117004876 shikimate transporter; Provisional; Region: PRK09952 266117004877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117004878 putative substrate translocation pore; other site 266117004879 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266117004880 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266117004881 trimer interface [polypeptide binding]; other site 266117004882 active site 266117004883 dimer interface [polypeptide binding]; other site 266117004884 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117004885 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 266117004886 putative NAD(P) binding site [chemical binding]; other site 266117004887 catalytic Zn binding site [ion binding]; other site 266117004888 structural Zn binding site [ion binding]; other site 266117004889 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266117004890 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266117004891 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266117004892 Int/Topo IB signature motif; other site 266117004893 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 266117004894 Helix-turn-helix domain; Region: HTH_17; pfam12728 266117004895 glutamate racemase; Provisional; Region: PRK00865 266117004896 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266117004897 SmpB-tmRNA interface; other site 266117004898 RNB domain; Region: RNB; pfam00773 266117004899 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 266117004900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266117004901 RNA binding site [nucleotide binding]; other site 266117004902 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 266117004903 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 266117004904 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266117004905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117004906 Walker A/P-loop; other site 266117004907 ATP binding site [chemical binding]; other site 266117004908 Q-loop/lid; other site 266117004909 ABC transporter signature motif; other site 266117004910 Walker B; other site 266117004911 D-loop; other site 266117004912 H-loop/switch region; other site 266117004913 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 266117004914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117004915 dimerization interface [polypeptide binding]; other site 266117004916 putative DNA binding site [nucleotide binding]; other site 266117004917 putative Zn2+ binding site [ion binding]; other site 266117004918 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266117004919 catalytic residues [active] 266117004920 Domain of unknown function (DUF202); Region: DUF202; cl09954 266117004921 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266117004922 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266117004923 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266117004924 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266117004925 This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757 266117004926 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266117004927 putative [Fe4-S4] binding site [ion binding]; other site 266117004928 putative molybdopterin cofactor binding site [chemical binding]; other site 266117004929 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 266117004930 putative molybdopterin cofactor binding site; other site 266117004931 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 266117004932 4Fe-4S binding domain; Region: Fer4; pfam00037 266117004933 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 266117004934 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 266117004935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117004936 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266117004937 putative dimerization interface [polypeptide binding]; other site 266117004938 Predicted transporter component [General function prediction only]; Region: COG2391 266117004939 Sulphur transport; Region: Sulf_transp; pfam04143 266117004940 Predicted transporter component [General function prediction only]; Region: COG2391 266117004941 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266117004942 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117004943 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117004944 active site residue [active] 266117004945 peptide chain release factor 2; Validated; Region: prfB; PRK00578 266117004946 PCRF domain; Region: PCRF; pfam03462 266117004947 RF-1 domain; Region: RF-1; pfam00472 266117004948 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266117004949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266117004950 ATP binding site [chemical binding]; other site 266117004951 putative Mg++ binding site [ion binding]; other site 266117004952 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266117004953 SEC-C motif; Region: SEC-C; pfam02810 266117004954 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266117004955 30S subunit binding site; other site 266117004956 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266117004957 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266117004958 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 266117004959 active site 266117004960 Substrate binding site; other site 266117004961 Mg++ binding site; other site 266117004962 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266117004963 putative trimer interface [polypeptide binding]; other site 266117004964 putative CoA binding site [chemical binding]; other site 266117004965 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266117004966 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117004967 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266117004968 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117004969 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266117004970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117004971 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266117004972 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 266117004973 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 266117004974 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 266117004975 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 266117004976 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 266117004977 NADH dehydrogenase subunit D; Validated; Region: PRK06075 266117004978 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 266117004979 NADH dehydrogenase subunit B; Validated; Region: PRK06411 266117004980 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 266117004981 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266117004982 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 266117004983 metal binding site [ion binding]; metal-binding site 266117004984 dimer interface [polypeptide binding]; other site 266117004985 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266117004986 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266117004987 hinge; other site 266117004988 active site 266117004989 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266117004990 gamma subunit interface [polypeptide binding]; other site 266117004991 epsilon subunit interface [polypeptide binding]; other site 266117004992 LBP interface [polypeptide binding]; other site 266117004993 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266117004994 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266117004995 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266117004996 alpha subunit interaction interface [polypeptide binding]; other site 266117004997 Walker A motif; other site 266117004998 ATP binding site [chemical binding]; other site 266117004999 Walker B motif; other site 266117005000 inhibitor binding site; inhibition site 266117005001 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266117005002 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266117005003 core domain interface [polypeptide binding]; other site 266117005004 delta subunit interface [polypeptide binding]; other site 266117005005 epsilon subunit interface [polypeptide binding]; other site 266117005006 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266117005007 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266117005008 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266117005009 beta subunit interaction interface [polypeptide binding]; other site 266117005010 Walker A motif; other site 266117005011 ATP binding site [chemical binding]; other site 266117005012 Walker B motif; other site 266117005013 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266117005014 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 266117005015 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266117005016 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266117005017 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 266117005018 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266117005019 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266117005020 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 266117005021 catalytic motif [active] 266117005022 Zn binding site [ion binding]; other site 266117005023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117005024 active site 266117005025 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266117005026 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266117005027 dimer interface [polypeptide binding]; other site 266117005028 active site 266117005029 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266117005030 folate binding site [chemical binding]; other site 266117005031 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 266117005032 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 266117005033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117005034 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266117005035 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266117005036 RF-1 domain; Region: RF-1; pfam00472 266117005037 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 266117005038 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 266117005039 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 266117005040 transcription termination factor Rho; Provisional; Region: PRK12608 266117005041 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266117005042 RNA binding site [nucleotide binding]; other site 266117005043 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266117005044 Walker A motif; other site 266117005045 ATP binding site [chemical binding]; other site 266117005046 Walker B motif; other site 266117005047 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266117005048 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 266117005049 putative active site [active] 266117005050 Predicted GTPase [General function prediction only]; Region: COG2403 266117005051 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266117005052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266117005053 active site 266117005054 metal binding site [ion binding]; metal-binding site 266117005055 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266117005056 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 266117005057 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266117005058 active site 266117005059 HIGH motif; other site 266117005060 KMSK motif region; other site 266117005061 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266117005062 tRNA binding surface [nucleotide binding]; other site 266117005063 anticodon binding site; other site 266117005064 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 266117005065 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266117005066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117005067 Coenzyme A binding pocket [chemical binding]; other site 266117005068 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 266117005069 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 266117005070 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266117005071 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117005072 active site 266117005073 catalytic site [active] 266117005074 Ferritin-like domain; Region: Ferritin_2; pfam13668 266117005075 Ferritin-like domain; Region: Ferritin_2; pfam13668 266117005076 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266117005077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117005078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117005079 DNA binding residues [nucleotide binding] 266117005080 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266117005081 Dodecin; Region: Dodecin; pfam07311 266117005082 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266117005083 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 266117005084 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 266117005085 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266117005086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117005087 motif II; other site 266117005088 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266117005089 putative active site pocket [active] 266117005090 dimerization interface [polypeptide binding]; other site 266117005091 putative catalytic residue [active] 266117005092 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266117005093 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 266117005094 N- and C-terminal domain interface [polypeptide binding]; other site 266117005095 active site 266117005096 catalytic site [active] 266117005097 metal binding site [ion binding]; metal-binding site 266117005098 carbohydrate binding site [chemical binding]; other site 266117005099 ATP binding site [chemical binding]; other site 266117005100 Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116 266117005101 dimer interface [polypeptide binding]; other site 266117005102 Citrate synthase; Region: Citrate_synt; pfam00285 266117005103 active site 266117005104 citrylCoA binding site [chemical binding]; other site 266117005105 oxalacetate/citrate binding site [chemical binding]; other site 266117005106 coenzyme A binding site [chemical binding]; other site 266117005107 catalytic triad [active] 266117005108 Tic20-like protein; Region: Tic20; pfam09685 266117005109 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 266117005110 intersubunit interface [polypeptide binding]; other site 266117005111 active site 266117005112 Zn2+ binding site [ion binding]; other site 266117005113 short chain dehydrogenase; Validated; Region: PRK08324 266117005114 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 266117005115 Zn2+ binding site [ion binding]; other site 266117005116 intersubunit interface [polypeptide binding]; other site 266117005117 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 266117005118 putative NAD(P) binding site [chemical binding]; other site 266117005119 active site 266117005120 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 266117005121 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 266117005122 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266117005123 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 266117005124 ligand binding site [chemical binding]; other site 266117005125 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117005126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117005127 TM-ABC transporter signature motif; other site 266117005128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117005129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117005130 TM-ABC transporter signature motif; other site 266117005131 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266117005132 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117005133 Walker A/P-loop; other site 266117005134 ATP binding site [chemical binding]; other site 266117005135 Q-loop/lid; other site 266117005136 ABC transporter signature motif; other site 266117005137 Walker B; other site 266117005138 D-loop; other site 266117005139 H-loop/switch region; other site 266117005140 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117005141 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 266117005142 N- and C-terminal domain interface [polypeptide binding]; other site 266117005143 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 266117005144 active site 266117005145 putative catalytic site [active] 266117005146 metal binding site [ion binding]; metal-binding site 266117005147 ATP binding site [chemical binding]; other site 266117005148 carbohydrate binding site [chemical binding]; other site 266117005149 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 266117005150 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266117005151 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266117005152 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266117005153 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266117005154 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117005155 acyl-activating enzyme (AAE) consensus motif; other site 266117005156 AMP binding site [chemical binding]; other site 266117005157 active site 266117005158 CoA binding site [chemical binding]; other site 266117005159 PAS domain; Region: PAS; smart00091 266117005160 PAS domain; Region: PAS_9; pfam13426 266117005161 putative active site [active] 266117005162 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 266117005163 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266117005164 anti sigma factor interaction site; other site 266117005165 regulatory phosphorylation site [posttranslational modification]; other site 266117005166 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266117005167 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 266117005168 substrate binding site [chemical binding]; other site 266117005169 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266117005170 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266117005171 substrate binding site [chemical binding]; other site 266117005172 ligand binding site [chemical binding]; other site 266117005173 Isochorismatase family; Region: Isochorismatase; pfam00857 266117005174 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266117005175 catalytic triad [active] 266117005176 conserved cis-peptide bond; other site 266117005177 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266117005178 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266117005179 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266117005180 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266117005181 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266117005182 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266117005183 active site 266117005184 catalytic residues [active] 266117005185 metal binding site [ion binding]; metal-binding site 266117005186 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117005187 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117005188 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117005189 FCD domain; Region: FCD; pfam07729 266117005190 amidase; Provisional; Region: PRK07235 266117005191 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266117005192 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266117005193 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117005194 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117005195 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266117005196 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266117005197 carboxyltransferase (CT) interaction site; other site 266117005198 biotinylation site [posttranslational modification]; other site 266117005199 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266117005200 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266117005201 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266117005202 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 266117005203 active site 266117005204 acyl-activating enzyme (AAE) consensus motif; other site 266117005205 putative CoA binding site [chemical binding]; other site 266117005206 AMP binding site [chemical binding]; other site 266117005207 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266117005208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117005209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117005210 active site 266117005211 Conserved TM helix; Region: TM_helix; pfam05552 266117005212 Conserved TM helix; Region: TM_helix; pfam05552 266117005213 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266117005214 Putative zinc-finger; Region: zf-HC2; pfam13490 266117005215 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266117005216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117005217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117005218 DNA binding residues [nucleotide binding] 266117005219 acetyl-CoA synthetase; Provisional; Region: PRK00174 266117005220 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117005221 acyl-activating enzyme (AAE) consensus motif; other site 266117005222 AMP binding site [chemical binding]; other site 266117005223 active site 266117005224 CoA binding site [chemical binding]; other site 266117005225 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 266117005226 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266117005227 putative lipid kinase; Reviewed; Region: PRK13057 266117005228 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 266117005229 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266117005230 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266117005231 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266117005232 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266117005233 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266117005234 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266117005235 tetrameric interface [polypeptide binding]; other site 266117005236 NAD binding site [chemical binding]; other site 266117005237 catalytic residues [active] 266117005238 KduI/IolB family; Region: KduI; pfam04962 266117005239 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 266117005240 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117005241 PYR/PP interface [polypeptide binding]; other site 266117005242 dimer interface [polypeptide binding]; other site 266117005243 TPP binding site [chemical binding]; other site 266117005244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117005245 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 266117005246 TPP-binding site; other site 266117005247 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266117005248 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117005249 Walker A/P-loop; other site 266117005250 ATP binding site [chemical binding]; other site 266117005251 Q-loop/lid; other site 266117005252 ABC transporter signature motif; other site 266117005253 Walker B; other site 266117005254 D-loop; other site 266117005255 H-loop/switch region; other site 266117005256 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117005257 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117005258 TM-ABC transporter signature motif; other site 266117005259 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266117005260 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266117005261 putative ligand binding site [chemical binding]; other site 266117005262 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266117005263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117005264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117005265 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266117005266 putative ligand binding site [chemical binding]; other site 266117005267 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117005268 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117005269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117005270 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266117005271 short chain dehydrogenase; Provisional; Region: PRK06198 266117005272 classical (c) SDRs; Region: SDR_c; cd05233 266117005273 NAD(P) binding site [chemical binding]; other site 266117005274 active site 266117005275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117005276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117005277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266117005278 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117005279 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266117005280 substrate binding site [chemical binding]; other site 266117005281 ATP binding site [chemical binding]; other site 266117005282 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 266117005283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 266117005284 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266117005285 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266117005286 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266117005287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117005289 DNA-binding site [nucleotide binding]; DNA binding site 266117005290 UTRA domain; Region: UTRA; pfam07702 266117005291 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 266117005292 active site 266117005293 trimer interface [polypeptide binding]; other site 266117005294 allosteric site; other site 266117005295 active site lid [active] 266117005296 hexamer (dimer of trimers) interface [polypeptide binding]; other site 266117005297 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 266117005298 HPr interaction site; other site 266117005299 glycerol kinase (GK) interaction site [polypeptide binding]; other site 266117005300 active site 266117005301 phosphorylation site [posttranslational modification] 266117005302 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 266117005303 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 266117005304 active site turn [active] 266117005305 phosphorylation site [posttranslational modification] 266117005306 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266117005307 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266117005308 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266117005309 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266117005310 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266117005311 dimerization domain swap beta strand [polypeptide binding]; other site 266117005312 regulatory protein interface [polypeptide binding]; other site 266117005313 active site 266117005314 regulatory phosphorylation site [posttranslational modification]; other site 266117005315 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 266117005316 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266117005317 NAD binding site [chemical binding]; other site 266117005318 homodimer interface [polypeptide binding]; other site 266117005319 homotetramer interface [polypeptide binding]; other site 266117005320 active site 266117005321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117005322 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 266117005323 dimer interface [polypeptide binding]; other site 266117005324 active site 266117005325 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 266117005326 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266117005327 acyl-activating enzyme (AAE) consensus motif; other site 266117005328 putative AMP binding site [chemical binding]; other site 266117005329 putative active site [active] 266117005330 putative CoA binding site [chemical binding]; other site 266117005331 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266117005332 active sites [active] 266117005333 tetramer interface [polypeptide binding]; other site 266117005334 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266117005335 MarR family; Region: MarR_2; pfam12802 266117005336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117005337 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 266117005338 Walker A/P-loop; other site 266117005339 ATP binding site [chemical binding]; other site 266117005340 Q-loop/lid; other site 266117005341 ABC transporter signature motif; other site 266117005342 Walker B; other site 266117005343 D-loop; other site 266117005344 H-loop/switch region; other site 266117005345 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 266117005346 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117005347 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 266117005348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117005349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117005350 active site 266117005351 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 266117005352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117005353 acyl-coenzyme A oxidase; Region: PLN02526 266117005354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117005355 active site 266117005356 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 266117005357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117005358 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266117005359 enoyl-CoA hydratase; Provisional; Region: PRK06688 266117005360 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117005361 substrate binding site [chemical binding]; other site 266117005362 oxyanion hole (OAH) forming residues; other site 266117005363 trimer interface [polypeptide binding]; other site 266117005364 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117005365 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266117005366 tetramerization interface [polypeptide binding]; other site 266117005367 NAD(P) binding site [chemical binding]; other site 266117005368 catalytic residues [active] 266117005369 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266117005370 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266117005371 trimer interface [polypeptide binding]; other site 266117005372 putative metal binding site [ion binding]; other site 266117005373 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266117005374 Phenylacetic acid degradation B; Region: PaaB; cl01371 266117005375 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266117005376 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 266117005377 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 266117005378 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266117005379 active site 266117005380 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266117005381 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 266117005382 catalytic Zn binding site [ion binding]; other site 266117005383 NAD binding site [chemical binding]; other site 266117005384 structural Zn binding site [ion binding]; other site 266117005385 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 266117005386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117005387 acyl-activating enzyme (AAE) consensus motif; other site 266117005388 AMP binding site [chemical binding]; other site 266117005389 active site 266117005390 CoA binding site [chemical binding]; other site 266117005391 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266117005392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117005393 NAD(P) binding site [chemical binding]; other site 266117005394 catalytic residues [active] 266117005395 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266117005396 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266117005397 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117005398 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117005399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117005400 enoyl-CoA hydratase; Provisional; Region: PRK07657 266117005401 substrate binding site [chemical binding]; other site 266117005402 oxyanion hole (OAH) forming residues; other site 266117005403 trimer interface [polypeptide binding]; other site 266117005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117005406 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 266117005407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266117005408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117005409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266117005410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266117005411 metal-binding site [ion binding] 266117005412 mercuric reductase; Region: MerA; TIGR02053 266117005413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266117005414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117005415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266117005416 Alkylmercury lyase; Region: MerB; pfam03243 266117005417 Alkylmercury lyase; Region: MerB; pfam03243 266117005418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117005419 dimerization interface [polypeptide binding]; other site 266117005420 putative DNA binding site [nucleotide binding]; other site 266117005421 putative Zn2+ binding site [ion binding]; other site 266117005422 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266117005423 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266117005424 catalytic residues [active] 266117005425 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266117005426 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266117005427 catalytic triad [active] 266117005428 N-terminal ACT domain of the yet uncharacterized, small (; 133 a.a.), putative amino acid binding protein, Af1403, and related domains; Region: ACT_Af1403; cd04874 266117005429 ACT domain-containing protein [General function prediction only]; Region: COG1707 266117005430 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266117005431 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266117005432 active site 266117005433 dimer interface [polypeptide binding]; other site 266117005434 non-prolyl cis peptide bond; other site 266117005435 insertion regions; other site 266117005436 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005438 putative substrate translocation pore; other site 266117005439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 266117005440 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266117005441 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 266117005442 dimerization interface [polypeptide binding]; other site 266117005443 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266117005444 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266117005445 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266117005446 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266117005447 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266117005448 active site 266117005449 dimer interface [polypeptide binding]; other site 266117005450 non-prolyl cis peptide bond; other site 266117005451 insertion regions; other site 266117005452 UBA/TS-N domain; Region: UBA; pfam00627 266117005453 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266117005454 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_4; cd08976 266117005455 putative DNA binding site [nucleotide binding]; other site 266117005456 catalytic residue [active] 266117005457 putative H2TH interface [polypeptide binding]; other site 266117005458 putative catalytic residues [active] 266117005459 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266117005460 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266117005461 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266117005462 active site 266117005463 Fe-S cluster binding site [ion binding]; other site 266117005464 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266117005465 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266117005466 substrate binding site [chemical binding]; other site 266117005467 AAA domain; Region: AAA_11; pfam13086 266117005468 AAA domain; Region: AAA_30; pfam13604 266117005469 AAA domain; Region: AAA_12; pfam13087 266117005470 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 266117005471 DNA methylase; Region: N6_N4_Mtase; cl17433 266117005472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117005473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117005474 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266117005475 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266117005476 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 266117005477 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 266117005478 putative metal binding site [ion binding]; other site 266117005479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117005480 active site 266117005481 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 266117005482 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 266117005483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117005484 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 266117005485 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 266117005486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117005487 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 266117005488 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 266117005489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266117005490 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266117005491 metal-binding site [ion binding] 266117005492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266117005493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117005494 ligand binding site [chemical binding]; other site 266117005495 flexible hinge region; other site 266117005496 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266117005497 putative switch regulator; other site 266117005498 non-specific DNA interactions [nucleotide binding]; other site 266117005499 DNA binding site [nucleotide binding] 266117005500 sequence specific DNA binding site [nucleotide binding]; other site 266117005501 putative cAMP binding site [chemical binding]; other site 266117005502 Domain of unknown function DUF77; Region: DUF77; pfam01910 266117005503 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 266117005504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117005505 Zn2+ binding site [ion binding]; other site 266117005506 Mg2+ binding site [ion binding]; other site 266117005507 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266117005508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117005509 Walker A motif; other site 266117005510 ATP binding site [chemical binding]; other site 266117005511 Walker B motif; other site 266117005512 arginine finger; other site 266117005513 Peptidase family M41; Region: Peptidase_M41; pfam01434 266117005514 ParB-like nuclease domain; Region: ParBc; cl02129 266117005515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117005516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117005517 Ferritin-like domain; Region: Ferritin; pfam00210 266117005518 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266117005519 dimerization interface [polypeptide binding]; other site 266117005520 DPS ferroxidase diiron center [ion binding]; other site 266117005521 ion pore; other site 266117005522 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 266117005523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266117005524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117005525 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117005526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117005527 DNA binding residues [nucleotide binding] 266117005528 Cupin domain; Region: Cupin_2; cl17218 266117005529 Uncharacterized membrane protein [Function unknown]; Region: COG3949 266117005530 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266117005531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117005532 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117005533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117005534 Ligand Binding Site [chemical binding]; other site 266117005535 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266117005536 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266117005537 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266117005538 Thioredoxin; Region: Thioredoxin_4; pfam13462 266117005539 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 266117005540 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 266117005541 VanW like protein; Region: VanW; pfam04294 266117005542 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266117005543 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266117005544 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117005545 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117005546 active site residue [active] 266117005547 Domain of unknown function DUF302; Region: DUF302; cl01364 266117005548 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117005549 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266117005550 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266117005551 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266117005552 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266117005553 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266117005554 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266117005555 catalytic residues [active] 266117005556 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266117005557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117005558 S-adenosylmethionine binding site [chemical binding]; other site 266117005559 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 266117005560 Domain of unknown function DUF87; Region: DUF87; pfam01935 266117005561 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266117005562 SWIM zinc finger; Region: SWIM; pfam04434 266117005563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117005564 trimer interface [polypeptide binding]; other site 266117005565 oxyanion hole (OAH) forming residues; other site 266117005566 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117005567 dimer interface [polypeptide binding]; other site 266117005568 active site 266117005569 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266117005570 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266117005571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117005572 acyl-activating enzyme (AAE) consensus motif; other site 266117005573 active site 266117005574 AMP binding site [chemical binding]; other site 266117005575 CoA binding site [chemical binding]; other site 266117005576 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 266117005577 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266117005578 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266117005579 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266117005580 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266117005581 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266117005582 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 266117005583 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 266117005584 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266117005585 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266117005586 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266117005587 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266117005588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117005589 acyl-activating enzyme (AAE) consensus motif; other site 266117005590 AMP binding site [chemical binding]; other site 266117005591 active site 266117005592 CoA binding site [chemical binding]; other site 266117005593 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117005594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117005595 DNA-binding site [nucleotide binding]; DNA binding site 266117005596 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266117005597 allantoate amidohydrolase; Reviewed; Region: PRK09290 266117005598 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266117005599 active site 266117005600 metal binding site [ion binding]; metal-binding site 266117005601 dimer interface [polypeptide binding]; other site 266117005602 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266117005603 homotrimer interaction site [polypeptide binding]; other site 266117005604 putative active site [active] 266117005605 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 266117005606 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 266117005607 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 266117005608 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266117005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117005610 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266117005611 DNA-binding site [nucleotide binding]; DNA binding site 266117005612 FCD domain; Region: FCD; pfam07729 266117005613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266117005614 Transposase; Region: HTH_Tnp_1; cl17663 266117005615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005616 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117005617 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266117005618 putative hydrophobic ligand binding site [chemical binding]; other site 266117005619 short chain dehydrogenase; Provisional; Region: PRK06125 266117005620 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266117005621 putative NAD(P) binding site [chemical binding]; other site 266117005622 putative active site [active] 266117005623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266117005624 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266117005625 acyl-activating enzyme (AAE) consensus motif; other site 266117005626 putative AMP binding site [chemical binding]; other site 266117005627 putative active site [active] 266117005628 putative CoA binding site [chemical binding]; other site 266117005629 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266117005630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117005631 substrate binding site [chemical binding]; other site 266117005632 oxyanion hole (OAH) forming residues; other site 266117005633 trimer interface [polypeptide binding]; other site 266117005634 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117005635 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266117005636 dimer interface [polypeptide binding]; other site 266117005637 substrate binding site [chemical binding]; other site 266117005638 metal binding site [ion binding]; metal-binding site 266117005639 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 266117005640 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266117005641 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266117005642 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266117005643 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266117005644 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266117005645 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266117005646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266117005647 catalytic loop [active] 266117005648 iron binding site [ion binding]; other site 266117005649 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266117005650 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266117005651 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266117005652 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266117005653 benzoate transport; Region: 2A0115; TIGR00895 266117005654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005655 putative substrate translocation pore; other site 266117005656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005657 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117005658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117005659 DNA-binding site [nucleotide binding]; DNA binding site 266117005660 FCD domain; Region: FCD; pfam07729 266117005661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117005662 acyl-coenzyme A oxidase; Region: PLN02526 266117005663 active site 266117005664 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266117005665 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266117005666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266117005667 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266117005668 substrate binding site [chemical binding]; other site 266117005669 dimer interface [polypeptide binding]; other site 266117005670 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117005671 ATP binding site [chemical binding]; other site 266117005672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117005673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117005674 TM-ABC transporter signature motif; other site 266117005675 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266117005676 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117005677 putative ligand binding site [chemical binding]; other site 266117005678 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266117005679 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117005680 Walker A/P-loop; other site 266117005681 ATP binding site [chemical binding]; other site 266117005682 Q-loop/lid; other site 266117005683 ABC transporter signature motif; other site 266117005684 Walker B; other site 266117005685 D-loop; other site 266117005686 H-loop/switch region; other site 266117005687 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117005688 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 266117005689 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 266117005690 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 266117005691 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266117005692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117005693 Walker A/P-loop; other site 266117005694 ATP binding site [chemical binding]; other site 266117005695 Q-loop/lid; other site 266117005696 ABC transporter signature motif; other site 266117005697 Walker B; other site 266117005698 D-loop; other site 266117005699 H-loop/switch region; other site 266117005700 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266117005701 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117005702 Walker A/P-loop; other site 266117005703 ATP binding site [chemical binding]; other site 266117005704 Q-loop/lid; other site 266117005705 ABC transporter signature motif; other site 266117005706 Walker B; other site 266117005707 D-loop; other site 266117005708 H-loop/switch region; other site 266117005709 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 266117005710 active site 266117005711 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266117005712 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117005713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117005714 DNA-binding site [nucleotide binding]; DNA binding site 266117005715 UTRA domain; Region: UTRA; pfam07702 266117005716 Homeodomain-like domain; Region: HTH_23; pfam13384 266117005717 Winged helix-turn helix; Region: HTH_29; pfam13551 266117005718 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117005719 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266117005720 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266117005721 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266117005722 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266117005723 active site 266117005724 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117005725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117005726 putative substrate translocation pore; other site 266117005727 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 266117005728 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266117005729 Catalytic site; other site 266117005730 Uncharacterized conserved protein [Function unknown]; Region: COG5495 266117005731 LexA repressor; Validated; Region: PRK00215 266117005732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117005733 putative DNA binding site [nucleotide binding]; other site 266117005734 putative Zn2+ binding site [ion binding]; other site 266117005735 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266117005736 Catalytic site [active] 266117005737 Homeodomain-like domain; Region: HTH_23; pfam13384 266117005738 Winged helix-turn helix; Region: HTH_29; pfam13551 266117005739 Homeodomain-like domain; Region: HTH_32; pfam13565 266117005740 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266117005741 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 266117005742 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 266117005743 active site 266117005744 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266117005745 generic binding surface II; other site 266117005746 generic binding surface I; other site 266117005747 Helix-turn-helix domain; Region: HTH_17; pfam12728 266117005748 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266117005749 putative active site [active] 266117005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117005751 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266117005752 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266117005753 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266117005754 Int/Topo IB signature motif; other site 266117005755 AAA domain; Region: AAA_32; pfam13654 266117005756 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266117005757 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266117005758 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266117005759 active site 266117005760 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 266117005761 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266117005762 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 266117005763 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266117005764 putative active site [active] 266117005765 putative metal binding site [ion binding]; other site 266117005766 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 266117005767 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 266117005768 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117005769 putative glycosyl transferase; Provisional; Region: PRK10307 266117005770 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266117005771 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 266117005772 putative ADP-binding pocket [chemical binding]; other site 266117005773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117005774 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 266117005775 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 266117005776 putative ADP-binding pocket [chemical binding]; other site 266117005777 O-Antigen ligase; Region: Wzy_C; pfam04932 266117005778 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266117005779 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 266117005780 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117005781 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 266117005782 Chain length determinant protein; Region: Wzz; cl15801 266117005783 Disaggregatase related; Region: Disaggr_assoc; pfam08480 266117005784 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117005785 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 266117005786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266117005787 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 266117005788 putative active site [active] 266117005789 putative cosubstrate binding site; other site 266117005790 putative substrate binding site [chemical binding]; other site 266117005791 catalytic site [active] 266117005792 O-Antigen ligase; Region: Wzy_C; pfam04932 266117005793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117005794 TPR repeat; Region: TPR_11; pfam13414 266117005795 TPR motif; other site 266117005796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117005797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117005798 DNA binding residues [nucleotide binding] 266117005799 dimerization interface [polypeptide binding]; other site 266117005800 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117005801 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266117005802 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117005803 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266117005804 active site 266117005805 Domain of unknown function DUF59; Region: DUF59; pfam01883 266117005806 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266117005807 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 266117005808 NAD binding site [chemical binding]; other site 266117005809 substrate binding site [chemical binding]; other site 266117005810 catalytic Zn binding site [ion binding]; other site 266117005811 structural Zn binding site [ion binding]; other site 266117005812 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266117005813 putative active site pocket [active] 266117005814 cleavage site 266117005815 PSP1 C-terminal conserved region; Region: PSP1; cl00770 266117005816 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 266117005817 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266117005818 thymidylate kinase; Validated; Region: tmk; PRK00698 266117005819 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266117005820 TMP-binding site; other site 266117005821 ATP-binding site [chemical binding]; other site 266117005822 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266117005823 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266117005824 catalytic triad [active] 266117005825 DNA topoisomerase I; Validated; Region: PRK07220 266117005826 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266117005827 active site 266117005828 putative interdomain interaction site [polypeptide binding]; other site 266117005829 putative metal-binding site [ion binding]; other site 266117005830 putative nucleotide binding site [chemical binding]; other site 266117005831 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266117005832 domain I; other site 266117005833 DNA binding groove [nucleotide binding] 266117005834 phosphate binding site [ion binding]; other site 266117005835 domain II; other site 266117005836 domain III; other site 266117005837 nucleotide binding site [chemical binding]; other site 266117005838 catalytic site [active] 266117005839 domain IV; other site 266117005840 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266117005841 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 266117005842 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 266117005843 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 266117005844 UbiA prenyltransferase family; Region: UbiA; pfam01040 266117005845 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 266117005846 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 266117005847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117005848 binding surface 266117005849 TPR motif; other site 266117005850 chlorohydrolase; Provisional; Region: PRK08418 266117005851 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117005852 active site 266117005853 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266117005854 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266117005855 substrate binding pocket [chemical binding]; other site 266117005856 chain length determination region; other site 266117005857 substrate-Mg2+ binding site; other site 266117005858 catalytic residues [active] 266117005859 aspartate-rich region 1; other site 266117005860 active site lid residues [active] 266117005861 aspartate-rich region 2; other site 266117005862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117005863 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266117005864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117005865 S-adenosylmethionine binding site [chemical binding]; other site 266117005866 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 266117005867 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117005868 inhibitor-cofactor binding pocket; inhibition site 266117005869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117005870 catalytic residue [active] 266117005871 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 266117005872 dimer interface [polypeptide binding]; other site 266117005873 active site 266117005874 Schiff base residues; other site 266117005875 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266117005876 active site 266117005877 SAM binding site [chemical binding]; other site 266117005878 homodimer interface [polypeptide binding]; other site 266117005879 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266117005880 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 266117005881 active site 266117005882 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 266117005883 domain interfaces; other site 266117005884 active site 266117005885 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 266117005886 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 266117005887 tRNA; other site 266117005888 putative tRNA binding site [nucleotide binding]; other site 266117005889 putative NADP binding site [chemical binding]; other site 266117005890 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 266117005891 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 266117005892 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 266117005893 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266117005894 trimer interface [polypeptide binding]; other site 266117005895 dimer interface [polypeptide binding]; other site 266117005896 putative active site [active] 266117005897 Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; Region: TEF1; COG5256 266117005898 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266117005899 G1 box; other site 266117005900 GTP/Mg2+ binding site [chemical binding]; other site 266117005901 G2 box; other site 266117005902 Switch I region; other site 266117005903 G3 box; other site 266117005904 Switch II region; other site 266117005905 G4 box; other site 266117005906 G5 box; other site 266117005907 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 266117005908 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 266117005909 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 266117005910 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266117005911 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 266117005912 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 266117005913 putative hydrolase; Region: TIGR03624 266117005914 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 266117005915 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 266117005916 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266117005917 generic binding surface I; other site 266117005918 generic binding surface II; other site 266117005919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117005920 Zn2+ binding site [ion binding]; other site 266117005921 Mg2+ binding site [ion binding]; other site 266117005922 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266117005923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117005924 dimer interface [polypeptide binding]; other site 266117005925 conserved gate region; other site 266117005926 putative PBP binding loops; other site 266117005927 ABC-ATPase subunit interface; other site 266117005928 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266117005929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117005930 dimer interface [polypeptide binding]; other site 266117005931 conserved gate region; other site 266117005932 putative PBP binding loops; other site 266117005933 ABC-ATPase subunit interface; other site 266117005934 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266117005935 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117005936 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266117005937 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266117005938 Walker A/P-loop; other site 266117005939 ATP binding site [chemical binding]; other site 266117005940 Q-loop/lid; other site 266117005941 ABC transporter signature motif; other site 266117005942 Walker B; other site 266117005943 D-loop; other site 266117005944 H-loop/switch region; other site 266117005945 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266117005946 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266117005947 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 266117005948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266117005949 putative Mg++ binding site [ion binding]; other site 266117005950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266117005951 nucleotide binding region [chemical binding]; other site 266117005952 ATP-binding site [chemical binding]; other site 266117005953 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 266117005954 Protein of unknown function (DUF790); Region: DUF790; pfam05626 266117005955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117005956 Coenzyme A binding pocket [chemical binding]; other site 266117005957 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266117005958 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266117005959 homotetramer interface [polypeptide binding]; other site 266117005960 ligand binding site [chemical binding]; other site 266117005961 catalytic site [active] 266117005962 NAD binding site [chemical binding]; other site 266117005963 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266117005964 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 266117005965 putative active site [active] 266117005966 catalytic site [active] 266117005967 putative metal binding site [ion binding]; other site 266117005968 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266117005969 active site 266117005970 catalytic triad [active] 266117005971 oxyanion hole [active] 266117005972 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266117005973 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266117005974 active site 266117005975 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 266117005976 active site 266117005977 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266117005978 triosephosphate isomerase; Provisional; Region: PRK14567 266117005979 substrate binding site [chemical binding]; other site 266117005980 dimer interface [polypeptide binding]; other site 266117005981 catalytic triad [active] 266117005982 Phosphoglycerate kinase; Region: PGK; pfam00162 266117005983 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 266117005984 substrate binding site [chemical binding]; other site 266117005985 hinge regions; other site 266117005986 ADP binding site [chemical binding]; other site 266117005987 catalytic site [active] 266117005988 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266117005989 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 266117005990 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266117005991 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 266117005992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 266117005993 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 266117005994 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 266117005995 phosphate binding site [ion binding]; other site 266117005996 putative substrate binding pocket [chemical binding]; other site 266117005997 dimer interface [polypeptide binding]; other site 266117005998 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266117005999 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 266117006000 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266117006001 putative dimer interface [polypeptide binding]; other site 266117006002 N-terminal domain interface [polypeptide binding]; other site 266117006003 putative substrate binding pocket (H-site) [chemical binding]; other site 266117006004 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 266117006005 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266117006006 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266117006007 GIY-YIG motif/motif A; other site 266117006008 active site 266117006009 catalytic site [active] 266117006010 putative DNA binding site [nucleotide binding]; other site 266117006011 metal binding site [ion binding]; metal-binding site 266117006012 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266117006013 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266117006014 amino acid transporter; Region: 2A0306; TIGR00909 266117006015 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 266117006016 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266117006017 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266117006018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117006019 ABC transporter signature motif; other site 266117006020 Walker B; other site 266117006021 D-loop; other site 266117006022 H-loop/switch region; other site 266117006023 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266117006024 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 266117006025 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266117006026 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266117006027 Bacterial PH domain; Region: DUF304; cl01348 266117006028 CAAX protease self-immunity; Region: Abi; pfam02517 266117006029 excinuclease ABC subunit B; Provisional; Region: PRK05298 266117006030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266117006031 ATP binding site [chemical binding]; other site 266117006032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266117006033 nucleotide binding region [chemical binding]; other site 266117006034 ATP-binding site [chemical binding]; other site 266117006035 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266117006036 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266117006037 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266117006038 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266117006039 catalytic residue [active] 266117006040 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266117006041 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266117006042 CoA-binding site [chemical binding]; other site 266117006043 ATP-binding [chemical binding]; other site 266117006044 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266117006045 RNA binding site [nucleotide binding]; other site 266117006046 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266117006047 RNA binding site [nucleotide binding]; other site 266117006048 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266117006049 RNA binding site [nucleotide binding]; other site 266117006050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266117006051 RNA binding site [nucleotide binding]; other site 266117006052 DNA polymerase I; Provisional; Region: PRK05755 266117006053 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266117006054 active site 266117006055 metal binding site 1 [ion binding]; metal-binding site 266117006056 putative 5' ssDNA interaction site; other site 266117006057 metal binding site 3; metal-binding site 266117006058 metal binding site 2 [ion binding]; metal-binding site 266117006059 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266117006060 putative DNA binding site [nucleotide binding]; other site 266117006061 putative metal binding site [ion binding]; other site 266117006062 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 266117006063 substrate binding site [chemical binding]; other site 266117006064 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266117006065 active site 266117006066 DNA binding site [nucleotide binding] 266117006067 catalytic site [active] 266117006068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117006069 S-adenosylmethionine binding site [chemical binding]; other site 266117006070 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266117006071 active site 266117006072 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266117006073 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266117006074 Walker A/P-loop; other site 266117006075 ATP binding site [chemical binding]; other site 266117006076 Q-loop/lid; other site 266117006077 ABC transporter signature motif; other site 266117006078 Walker B; other site 266117006079 D-loop; other site 266117006080 H-loop/switch region; other site 266117006081 Branched-chain amino acid ATP-binding cassette transporter; Region: BCA_ABC_TP_C; pfam12399 266117006082 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266117006083 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266117006084 Walker A/P-loop; other site 266117006085 ATP binding site [chemical binding]; other site 266117006086 Q-loop/lid; other site 266117006087 ABC transporter signature motif; other site 266117006088 Walker B; other site 266117006089 D-loop; other site 266117006090 H-loop/switch region; other site 266117006091 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266117006092 TM-ABC transporter signature motif; other site 266117006093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117006094 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266117006095 TM-ABC transporter signature motif; other site 266117006096 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266117006097 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266117006098 dimerization interface [polypeptide binding]; other site 266117006099 ligand binding site [chemical binding]; other site 266117006100 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 266117006101 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 266117006102 lycopene cyclase; Region: lycopene_cycl; TIGR01789 266117006103 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 266117006104 pyruvate carboxylase; Reviewed; Region: PRK12999 266117006105 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117006106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117006107 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266117006108 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266117006109 active site 266117006110 catalytic residues [active] 266117006111 metal binding site [ion binding]; metal-binding site 266117006112 homodimer binding site [polypeptide binding]; other site 266117006113 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266117006114 carboxyltransferase (CT) interaction site; other site 266117006115 biotinylation site [posttranslational modification]; other site 266117006116 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266117006117 dimer interface [polypeptide binding]; other site 266117006118 substrate binding site [chemical binding]; other site 266117006119 metal binding sites [ion binding]; metal-binding site 266117006120 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 266117006121 aromatic arch; other site 266117006122 DCoH dimer interaction site [polypeptide binding]; other site 266117006123 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266117006124 DCoH tetramer interaction site [polypeptide binding]; other site 266117006125 substrate binding site [chemical binding]; other site 266117006126 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266117006127 Catalytic site; other site 266117006128 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266117006129 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266117006130 proposed catalytic triad [active] 266117006131 conserved cys residue [active] 266117006132 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 266117006133 beta-galactosidase; Region: BGL; TIGR03356 266117006134 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 266117006135 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 266117006136 putative transporter; Provisional; Region: PRK10484 266117006137 Na binding site [ion binding]; other site 266117006138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117006139 active site 266117006140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117006141 catalytic tetrad [active] 266117006142 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 266117006143 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 266117006144 active site 266117006145 catalytic site [active] 266117006146 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 266117006147 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 266117006148 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266117006149 acyl-CoA synthetase; Validated; Region: PRK08162 266117006150 acyl-activating enzyme (AAE) consensus motif; other site 266117006151 putative active site [active] 266117006152 AMP binding site [chemical binding]; other site 266117006153 putative CoA binding site [chemical binding]; other site 266117006154 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 266117006155 enoyl-CoA hydratase; Validated; Region: PRK08139 266117006156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117006157 substrate binding site [chemical binding]; other site 266117006158 oxyanion hole (OAH) forming residues; other site 266117006159 trimer interface [polypeptide binding]; other site 266117006160 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 266117006161 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 266117006162 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117006163 dimer interface [polypeptide binding]; other site 266117006164 active site 266117006165 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266117006166 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266117006167 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117006168 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117006169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117006170 substrate binding site [chemical binding]; other site 266117006171 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266117006172 oxyanion hole (OAH) forming residues; other site 266117006173 trimer interface [polypeptide binding]; other site 266117006174 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266117006175 active site 2 [active] 266117006176 active site 1 [active] 266117006177 Predicted transcriptional regulators [Transcription]; Region: COG1695 266117006178 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266117006179 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 266117006180 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 266117006181 acyl-activating enzyme (AAE) consensus motif; other site 266117006182 putative AMP binding site [chemical binding]; other site 266117006183 putative active site [active] 266117006184 putative CoA binding site [chemical binding]; other site 266117006185 acyl-coenzyme A oxidase; Region: PLN02526 266117006186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117006187 active site 266117006188 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266117006189 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266117006190 NAD(P) binding site [chemical binding]; other site 266117006191 isocitrate lyase; Provisional; Region: PRK15063 266117006192 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266117006193 tetramer interface [polypeptide binding]; other site 266117006194 active site 266117006195 Mg2+/Mn2+ binding site [ion binding]; other site 266117006196 malate synthase A; Region: malate_syn_A; TIGR01344 266117006197 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 266117006198 active site 266117006199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266117006200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117006201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266117006202 dimerization interface [polypeptide binding]; other site 266117006203 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266117006204 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 266117006205 active site 266117006206 catalytic triad [active] 266117006207 oxyanion hole [active] 266117006208 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266117006209 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 266117006210 active site 266117006211 catalytic site [active] 266117006212 metal binding site [ion binding]; metal-binding site 266117006213 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266117006214 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266117006215 Walker A/P-loop; other site 266117006216 ATP binding site [chemical binding]; other site 266117006217 Q-loop/lid; other site 266117006218 ABC transporter signature motif; other site 266117006219 Walker B; other site 266117006220 D-loop; other site 266117006221 H-loop/switch region; other site 266117006222 TOBE domain; Region: TOBE_2; pfam08402 266117006223 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266117006224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117006225 dimer interface [polypeptide binding]; other site 266117006226 conserved gate region; other site 266117006227 putative PBP binding loops; other site 266117006228 ABC-ATPase subunit interface; other site 266117006229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117006230 dimer interface [polypeptide binding]; other site 266117006231 conserved gate region; other site 266117006232 putative PBP binding loops; other site 266117006233 ABC-ATPase subunit interface; other site 266117006234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266117006235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117006236 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266117006237 tartrate dehydrogenase; Provisional; Region: PRK08194 266117006238 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 266117006239 Phosphotransferase enzyme family; Region: APH; pfam01636 266117006240 active site 266117006241 ATP binding site [chemical binding]; other site 266117006242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266117006243 active site 266117006244 ATP binding site [chemical binding]; other site 266117006245 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266117006246 substrate binding site [chemical binding]; other site 266117006247 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266117006248 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266117006249 active site 266117006250 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266117006251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117006252 ligand binding site [chemical binding]; other site 266117006253 flexible hinge region; other site 266117006254 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266117006255 non-specific DNA interactions [nucleotide binding]; other site 266117006256 DNA binding site [nucleotide binding] 266117006257 sequence specific DNA binding site [nucleotide binding]; other site 266117006258 putative cAMP binding site [chemical binding]; other site 266117006259 Hydrogenase formation hypA family; Region: HypD; cl12072 266117006260 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266117006261 phosphofructokinase; Region: PFK_mixed; TIGR02483 266117006262 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 266117006263 active site 266117006264 ADP/pyrophosphate binding site [chemical binding]; other site 266117006265 dimerization interface [polypeptide binding]; other site 266117006266 allosteric effector site; other site 266117006267 fructose-1,6-bisphosphate binding site; other site 266117006268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266117006269 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 266117006270 Walker A/P-loop; other site 266117006271 ATP binding site [chemical binding]; other site 266117006272 Q-loop/lid; other site 266117006273 ABC transporter signature motif; other site 266117006274 Walker B; other site 266117006275 D-loop; other site 266117006276 H-loop/switch region; other site 266117006277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266117006278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117006279 dimer interface [polypeptide binding]; other site 266117006280 conserved gate region; other site 266117006281 putative PBP binding loops; other site 266117006282 ABC-ATPase subunit interface; other site 266117006283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266117006284 NMT1/THI5 like; Region: NMT1; pfam09084 266117006285 membrane-bound complex binding site; other site 266117006286 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266117006287 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266117006288 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266117006289 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266117006290 substrate binding site [chemical binding]; other site 266117006291 active site 266117006292 catalytic residues [active] 266117006293 heterodimer interface [polypeptide binding]; other site 266117006294 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266117006295 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266117006296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117006297 catalytic residue [active] 266117006298 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 266117006299 active site 266117006300 PAS domain; Region: PAS; smart00091 266117006301 putative active site [active] 266117006302 heme pocket [chemical binding]; other site 266117006303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117006304 metal binding site [ion binding]; metal-binding site 266117006305 active site 266117006306 I-site; other site 266117006307 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117006308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117006309 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266117006310 active site 266117006311 ribulose/triose binding site [chemical binding]; other site 266117006312 phosphate binding site [ion binding]; other site 266117006313 substrate (anthranilate) binding pocket [chemical binding]; other site 266117006314 product (indole) binding pocket [chemical binding]; other site 266117006315 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266117006316 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266117006317 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266117006318 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266117006319 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 266117006320 glutamine binding [chemical binding]; other site 266117006321 catalytic triad [active] 266117006322 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266117006323 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266117006324 putative alpha-glucosidase; Provisional; Region: PRK10658 266117006325 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 266117006326 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 266117006327 trimer interface [polypeptide binding]; other site 266117006328 active site 266117006329 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 266117006330 catalytic site [active] 266117006331 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266117006332 classical (c) SDRs; Region: SDR_c; cd05233 266117006333 NAD(P) binding site [chemical binding]; other site 266117006334 active site 266117006335 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266117006336 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266117006337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117006338 motif II; other site 266117006339 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 266117006340 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266117006341 putative deacylase active site [active] 266117006342 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266117006343 Beta-lactamase; Region: Beta-lactamase; pfam00144 266117006344 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266117006345 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266117006346 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266117006347 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266117006348 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 266117006349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266117006350 MOSC domain; Region: MOSC; pfam03473 266117006351 3-alpha domain; Region: 3-alpha; pfam03475 266117006352 MarR family; Region: MarR; pfam01047 266117006353 Protoglobin; Region: Protoglobin; pfam11563 266117006354 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266117006355 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117006356 NAD(P) binding site [chemical binding]; other site 266117006357 fatty acyl-CoA reductase; Region: PLN02996 266117006358 fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236 266117006359 putative NAD(P) binding site [chemical binding]; other site 266117006360 active site 266117006361 putative substrate binding site [chemical binding]; other site 266117006362 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 266117006363 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266117006364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117006365 motif II; other site 266117006366 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 266117006367 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117006368 Sulfatase; Region: Sulfatase; pfam00884 266117006369 anthranilate synthase component I; Provisional; Region: PRK13565 266117006370 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266117006371 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266117006372 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266117006373 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 266117006374 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266117006375 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266117006376 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266117006377 substrate binding site [chemical binding]; other site 266117006378 glutamase interaction surface [polypeptide binding]; other site 266117006379 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 266117006380 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266117006381 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 266117006382 active site 266117006383 substrate binding site [chemical binding]; other site 266117006384 metal binding site [ion binding]; metal-binding site 266117006385 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266117006386 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266117006387 23S rRNA interface [nucleotide binding]; other site 266117006388 L3 interface [polypeptide binding]; other site 266117006389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266117006390 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 266117006391 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266117006392 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266117006393 dimerization interface 3.5A [polypeptide binding]; other site 266117006394 active site 266117006395 Cobalt transport protein; Region: CbiQ; cl00463 266117006396 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266117006397 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117006398 Walker A/P-loop; other site 266117006399 ATP binding site [chemical binding]; other site 266117006400 Q-loop/lid; other site 266117006401 ABC transporter signature motif; other site 266117006402 Walker B; other site 266117006403 D-loop; other site 266117006404 H-loop/switch region; other site 266117006405 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117006406 Walker A/P-loop; other site 266117006407 ATP binding site [chemical binding]; other site 266117006408 ABC transporter; Region: ABC_tran; pfam00005 266117006409 Q-loop/lid; other site 266117006410 ABC transporter signature motif; other site 266117006411 Walker B; other site 266117006412 D-loop; other site 266117006413 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266117006414 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266117006415 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266117006416 alphaNTD homodimer interface [polypeptide binding]; other site 266117006417 alphaNTD - beta interaction site [polypeptide binding]; other site 266117006418 alphaNTD - beta' interaction site [polypeptide binding]; other site 266117006419 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266117006420 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266117006421 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266117006422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266117006423 RNA binding surface [nucleotide binding]; other site 266117006424 30S ribosomal protein S11; Validated; Region: PRK05309 266117006425 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266117006426 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266117006427 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266117006428 rRNA binding site [nucleotide binding]; other site 266117006429 predicted 30S ribosome binding site; other site 266117006430 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266117006431 active site 266117006432 adenylate kinase; Reviewed; Region: adk; PRK00279 266117006433 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266117006434 AMP-binding site [chemical binding]; other site 266117006435 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266117006436 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266117006437 SecY translocase; Region: SecY; pfam00344 266117006438 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266117006439 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266117006440 23S rRNA binding site [nucleotide binding]; other site 266117006441 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266117006442 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266117006443 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266117006444 23S rRNA interface [nucleotide binding]; other site 266117006445 5S rRNA interface [nucleotide binding]; other site 266117006446 L27 interface [polypeptide binding]; other site 266117006447 L5 interface [polypeptide binding]; other site 266117006448 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266117006449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266117006450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266117006451 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266117006452 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 266117006453 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266117006454 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266117006455 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266117006456 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266117006457 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266117006458 RNA binding site [nucleotide binding]; other site 266117006459 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266117006460 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266117006461 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266117006462 L23 interface [polypeptide binding]; other site 266117006463 signal recognition particle (SRP54) interaction site; other site 266117006464 trigger factor interaction site; other site 266117006465 23S rRNA interface [nucleotide binding]; other site 266117006466 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266117006467 23S rRNA interface [nucleotide binding]; other site 266117006468 5S rRNA interface [nucleotide binding]; other site 266117006469 putative antibiotic binding site [chemical binding]; other site 266117006470 L25 interface [polypeptide binding]; other site 266117006471 L27 interface [polypeptide binding]; other site 266117006472 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 266117006473 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266117006474 G-X-X-G motif; other site 266117006475 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266117006476 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266117006477 putative translocon binding site; other site 266117006478 protein-rRNA interface [nucleotide binding]; other site 266117006479 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266117006480 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266117006481 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266117006482 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266117006483 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266117006484 50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953 266117006485 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 266117006486 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266117006487 elongation factor Tu; Reviewed; Region: PRK00049 266117006488 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266117006489 G1 box; other site 266117006490 GEF interaction site [polypeptide binding]; other site 266117006491 GTP/Mg2+ binding site [chemical binding]; other site 266117006492 Switch I region; other site 266117006493 G2 box; other site 266117006494 G3 box; other site 266117006495 Switch II region; other site 266117006496 G4 box; other site 266117006497 G5 box; other site 266117006498 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266117006499 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266117006500 Antibiotic Binding Site [chemical binding]; other site 266117006501 elongation factor G; Reviewed; Region: PRK00007 266117006502 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266117006503 G1 box; other site 266117006504 putative GEF interaction site [polypeptide binding]; other site 266117006505 GTP/Mg2+ binding site [chemical binding]; other site 266117006506 Switch I region; other site 266117006507 G2 box; other site 266117006508 G3 box; other site 266117006509 Switch II region; other site 266117006510 G4 box; other site 266117006511 G5 box; other site 266117006512 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266117006513 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266117006514 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266117006515 30S ribosomal protein S7; Validated; Region: PRK05302 266117006516 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266117006517 S17 interaction site [polypeptide binding]; other site 266117006518 S8 interaction site; other site 266117006519 16S rRNA interaction site [nucleotide binding]; other site 266117006520 streptomycin interaction site [chemical binding]; other site 266117006521 23S rRNA interaction site [nucleotide binding]; other site 266117006522 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266117006523 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266117006524 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 266117006525 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266117006526 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266117006527 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266117006528 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266117006529 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 266117006530 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266117006531 G-loop; other site 266117006532 DNA binding site [nucleotide binding] 266117006533 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266117006534 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 266117006535 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 266117006536 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266117006537 RPB1 interaction site [polypeptide binding]; other site 266117006538 RPB10 interaction site [polypeptide binding]; other site 266117006539 RPB11 interaction site [polypeptide binding]; other site 266117006540 RPB3 interaction site [polypeptide binding]; other site 266117006541 RPB12 interaction site [polypeptide binding]; other site 266117006542 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266117006543 core dimer interface [polypeptide binding]; other site 266117006544 peripheral dimer interface [polypeptide binding]; other site 266117006545 L10 interface [polypeptide binding]; other site 266117006546 L11 interface [polypeptide binding]; other site 266117006547 putative EF-Tu interaction site [polypeptide binding]; other site 266117006548 putative EF-G interaction site [polypeptide binding]; other site 266117006549 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266117006550 23S rRNA interface [nucleotide binding]; other site 266117006551 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266117006552 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266117006553 mRNA/rRNA interface [nucleotide binding]; other site 266117006554 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266117006555 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266117006556 putative thiostrepton binding site; other site 266117006557 23S rRNA interface [nucleotide binding]; other site 266117006558 L7/L12 interface [polypeptide binding]; other site 266117006559 L25 interface [polypeptide binding]; other site 266117006560 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266117006561 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266117006562 putative homodimer interface [polypeptide binding]; other site 266117006563 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266117006564 heterodimer interface [polypeptide binding]; other site 266117006565 homodimer interface [polypeptide binding]; other site 266117006566 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 266117006567 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 266117006568 elongation factor Tu; Reviewed; Region: PRK00049 266117006569 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266117006570 G1 box; other site 266117006571 GEF interaction site [polypeptide binding]; other site 266117006572 GTP/Mg2+ binding site [chemical binding]; other site 266117006573 Switch I region; other site 266117006574 G2 box; other site 266117006575 G3 box; other site 266117006576 Switch II region; other site 266117006577 G4 box; other site 266117006578 G5 box; other site 266117006579 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266117006580 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266117006581 Antibiotic Binding Site [chemical binding]; other site 266117006582 YacP-like NYN domain; Region: NYN_YacP; pfam05991 266117006583 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 266117006584 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266117006585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266117006586 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 266117006587 active site 266117006588 HIGH motif; other site 266117006589 nucleotide binding site [chemical binding]; other site 266117006590 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266117006591 KMSKS motif; other site 266117006592 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266117006593 tRNA binding surface [nucleotide binding]; other site 266117006594 anticodon binding site; other site 266117006595 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266117006596 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 266117006597 active site 266117006598 HIGH motif; other site 266117006599 KMSKS motif; other site 266117006600 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266117006601 homotrimer interaction site [polypeptide binding]; other site 266117006602 zinc binding site [ion binding]; other site 266117006603 CDP-binding sites; other site 266117006604 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266117006605 substrate binding site; other site 266117006606 dimer interface; other site 266117006607 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 266117006608 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 266117006609 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 266117006610 DNA repair protein RadA; Provisional; Region: PRK11823 266117006611 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266117006612 Walker A motif; other site 266117006613 ATP binding site [chemical binding]; other site 266117006614 Walker B motif; other site 266117006615 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266117006616 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 266117006617 Clp amino terminal domain; Region: Clp_N; pfam02861 266117006618 Clp amino terminal domain; Region: Clp_N; pfam02861 266117006619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117006620 Walker A motif; other site 266117006621 ATP binding site [chemical binding]; other site 266117006622 Walker B motif; other site 266117006623 arginine finger; other site 266117006624 UvrB/uvrC motif; Region: UVR; pfam02151 266117006625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117006626 Walker A motif; other site 266117006627 ATP binding site [chemical binding]; other site 266117006628 Walker B motif; other site 266117006629 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266117006630 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 266117006631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266117006632 active site 266117006633 nucleotide binding site [chemical binding]; other site 266117006634 HIGH motif; other site 266117006635 KMSKS motif; other site 266117006636 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266117006637 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266117006638 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266117006639 pantothenate kinase; Reviewed; Region: PRK13318 266117006640 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266117006641 catalytic center binding site [active] 266117006642 ATP binding site [chemical binding]; other site 266117006643 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266117006644 dihydropteroate synthase; Region: DHPS; TIGR01496 266117006645 substrate binding pocket [chemical binding]; other site 266117006646 dimer interface [polypeptide binding]; other site 266117006647 inhibitor binding site; inhibition site 266117006648 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266117006649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117006650 Walker A motif; other site 266117006651 ATP binding site [chemical binding]; other site 266117006652 Walker B motif; other site 266117006653 arginine finger; other site 266117006654 Peptidase family M41; Region: Peptidase_M41; pfam01434 266117006655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117006656 active site 266117006657 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 266117006658 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266117006659 Ligand Binding Site [chemical binding]; other site 266117006660 TilS substrate C-terminal domain; Region: TilS_C; smart00977 266117006661 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 266117006662 active site 266117006663 catalytic triad [active] 266117006664 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 266117006665 GTP-binding protein YchF; Reviewed; Region: PRK09601 266117006666 YchF GTPase; Region: YchF; cd01900 266117006667 G1 box; other site 266117006668 GTP/Mg2+ binding site [chemical binding]; other site 266117006669 Switch I region; other site 266117006670 G2 box; other site 266117006671 Switch II region; other site 266117006672 G3 box; other site 266117006673 G4 box; other site 266117006674 G5 box; other site 266117006675 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 266117006676 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266117006677 trimerization site [polypeptide binding]; other site 266117006678 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266117006679 active site 266117006680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117006681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117006682 active site 266117006683 metal binding site [ion binding]; metal-binding site 266117006684 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266117006685 amidase catalytic site [active] 266117006686 Zn binding residues [ion binding]; other site 266117006687 substrate binding site [chemical binding]; other site 266117006688 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 266117006689 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 266117006690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117006691 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266117006692 dimer interface [polypeptide binding]; other site 266117006693 active site 266117006694 metal binding site [ion binding]; metal-binding site 266117006695 glutathione binding site [chemical binding]; other site 266117006696 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 266117006697 ABC1 family; Region: ABC1; cl17513 266117006698 Protein of unknown function (DUF422); Region: DUF422; pfam04240 266117006699 prenyltransferase; Provisional; Region: ubiA; PRK13595 266117006700 UbiA prenyltransferase family; Region: UbiA; pfam01040 266117006701 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266117006702 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266117006703 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266117006704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117006705 catalytic residue [active] 266117006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117006707 putative substrate translocation pore; other site 266117006708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117006709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117006710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117006711 Response regulator receiver domain; Region: Response_reg; pfam00072 266117006712 active site 266117006713 phosphorylation site [posttranslational modification] 266117006714 intermolecular recognition site; other site 266117006715 dimerization interface [polypeptide binding]; other site 266117006716 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 266117006717 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 266117006718 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266117006719 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 266117006720 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 266117006721 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266117006722 Int/Topo IB signature motif; other site 266117006723 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 266117006724 SWIM zinc finger; Region: SWIM; pfam04434 266117006725 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266117006726 Helix-turn-helix domain; Region: HTH_38; pfam13936 266117006727 Homeodomain-like domain; Region: HTH_32; pfam13565 266117006728 Integrase core domain; Region: rve; pfam00665 266117006729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266117006730 Transposase; Region: HTH_Tnp_1; pfam01527 266117006731 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266117006732 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266117006733 minor groove reading motif; other site 266117006734 helix-hairpin-helix signature motif; other site 266117006735 substrate binding pocket [chemical binding]; other site 266117006736 active site 266117006737 Type II restriction endonuclease (RE_Alw26IDE); Region: RE_Alw26IDE; pfam09665 266117006738 type II restriction endonuclease, Alw26I/Eco31I/Esp3I family; Region: restrict_Alw26I; TIGR02986 266117006739 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266117006740 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266117006741 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266117006742 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266117006743 cofactor binding site; other site 266117006744 DNA binding site [nucleotide binding] 266117006745 substrate interaction site [chemical binding]; other site 266117006746 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 266117006747 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266117006748 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 266117006749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117006750 sequence-specific DNA binding site [nucleotide binding]; other site 266117006751 salt bridge; other site 266117006752 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266117006753 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266117006754 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266117006755 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117006756 Amidohydrolase; Region: Amidohydro_2; pfam04909 266117006757 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266117006758 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117006759 hypothetical protein; Provisional; Region: PRK06847 266117006760 hypothetical protein; Provisional; Region: PRK07236 266117006761 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 266117006762 tetramer interface [polypeptide binding]; other site 266117006763 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 266117006764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266117006765 active site 266117006766 metal binding site [ion binding]; metal-binding site 266117006767 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266117006768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266117006769 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266117006770 dimerization interface [polypeptide binding]; other site 266117006771 substrate binding pocket [chemical binding]; other site 266117006772 Putative cyclase; Region: Cyclase; pfam04199 266117006773 Cupin domain; Region: Cupin_2; pfam07883 266117006774 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266117006775 Proline racemase; Region: Pro_racemase; pfam05544 266117006776 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 266117006777 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 266117006778 putative active site [active] 266117006779 putative FMN binding site [chemical binding]; other site 266117006780 putative substrate binding site [chemical binding]; other site 266117006781 putative catalytic residue [active] 266117006782 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 266117006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117006784 putative substrate translocation pore; other site 266117006785 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266117006786 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117006787 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117006788 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266117006789 NAD(P) binding site [chemical binding]; other site 266117006790 catalytic residues [active] 266117006791 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266117006792 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266117006793 inhibitor site; inhibition site 266117006794 active site 266117006795 dimer interface [polypeptide binding]; other site 266117006796 catalytic residue [active] 266117006797 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266117006798 Proline racemase; Region: Pro_racemase; pfam05544 266117006799 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117006800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117006801 DNA-binding site [nucleotide binding]; DNA binding site 266117006802 FCD domain; Region: FCD; pfam07729 266117006803 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 266117006804 Staphylococcal nuclease homologues; Region: SNc; smart00318 266117006805 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266117006806 Catalytic site; other site 266117006807 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 266117006808 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266117006809 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117006810 PYR/PP interface [polypeptide binding]; other site 266117006811 dimer interface [polypeptide binding]; other site 266117006812 TPP binding site [chemical binding]; other site 266117006813 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117006814 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266117006815 TPP-binding site [chemical binding]; other site 266117006816 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 266117006817 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266117006818 hypothetical protein; Provisional; Region: PRK07236 266117006819 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266117006820 active site 266117006821 FMN binding site [chemical binding]; other site 266117006822 substrate binding site [chemical binding]; other site 266117006823 homotetramer interface [polypeptide binding]; other site 266117006824 catalytic residue [active] 266117006825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117006826 classical (c) SDRs; Region: SDR_c; cd05233 266117006827 NAD(P) binding site [chemical binding]; other site 266117006828 active site 266117006829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266117006830 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266117006831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117006832 substrate binding site [chemical binding]; other site 266117006833 oxyanion hole (OAH) forming residues; other site 266117006834 trimer interface [polypeptide binding]; other site 266117006835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117006836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117006837 active site 266117006838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117006839 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266117006840 acyl-activating enzyme (AAE) consensus motif; other site 266117006841 AMP binding site [chemical binding]; other site 266117006842 active site 266117006843 CoA binding site [chemical binding]; other site 266117006844 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266117006845 homotrimer interaction site [polypeptide binding]; other site 266117006846 putative active site [active] 266117006847 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266117006848 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266117006849 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266117006850 active site 266117006851 ATP binding site [chemical binding]; other site 266117006852 substrate binding site [chemical binding]; other site 266117006853 activation loop (A-loop); other site 266117006854 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 266117006855 Transposase domain (DUF772); Region: DUF772; pfam05598 266117006856 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266117006857 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266117006858 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 266117006859 Lipase (class 2); Region: Lipase_2; pfam01674 266117006860 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 266117006861 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266117006862 active site 266117006863 metal binding site [ion binding]; metal-binding site 266117006864 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 266117006865 putative active site [active] 266117006866 dimerization interface [polypeptide binding]; other site 266117006867 putative tRNAtyr binding site [nucleotide binding]; other site 266117006868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117006869 S-adenosylmethionine binding site [chemical binding]; other site 266117006870 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266117006871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266117006872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266117006873 ABC transporter; Region: ABC_tran_2; pfam12848 266117006874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266117006875 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266117006876 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266117006877 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266117006878 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 266117006879 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266117006880 active site 266117006881 metal binding site [ion binding]; metal-binding site 266117006882 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266117006883 oligomerisation interface [polypeptide binding]; other site 266117006884 mobile loop; other site 266117006885 roof hairpin; other site 266117006886 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266117006887 catalytic residues [active] 266117006888 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 266117006889 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 266117006890 putative substrate binding site [chemical binding]; other site 266117006891 putative ATP binding site [chemical binding]; other site 266117006892 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266117006893 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266117006894 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 266117006895 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266117006896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266117006897 catalytic residues [active] 266117006898 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266117006899 active site 266117006900 dimer interface [polypeptide binding]; other site 266117006901 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266117006902 IHF dimer interface [polypeptide binding]; other site 266117006903 IHF - DNA interface [nucleotide binding]; other site 266117006904 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 266117006905 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 266117006906 putative homodimer interface [polypeptide binding]; other site 266117006907 putative homotetramer interface [polypeptide binding]; other site 266117006908 putative allosteric switch controlling residues; other site 266117006909 putative metal binding site [ion binding]; other site 266117006910 putative homodimer-homodimer interface [polypeptide binding]; other site 266117006911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266117006912 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266117006913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117006914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266117006915 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 266117006916 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266117006917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117006918 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117006919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117006920 DNA binding residues [nucleotide binding] 266117006921 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266117006922 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266117006923 active site 266117006924 dimerization interface [polypeptide binding]; other site 266117006925 Transglycosylase; Region: Transgly; pfam00912 266117006926 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266117006927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266117006928 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266117006929 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266117006930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117006931 catalytic residue [active] 266117006932 pyrophosphatase PpaX; Provisional; Region: PRK13288 266117006933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117006934 motif II; other site 266117006935 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266117006936 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 266117006937 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 266117006938 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 266117006939 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 266117006940 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 266117006941 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 266117006942 RibD C-terminal domain; Region: RibD_C; cl17279 266117006943 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266117006944 Helix-turn-helix domain; Region: HTH_18; pfam12833 266117006945 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 266117006946 elongation factor G; Reviewed; Region: PRK12740 266117006947 G1 box; other site 266117006948 putative GEF interaction site [polypeptide binding]; other site 266117006949 GTP/Mg2+ binding site [chemical binding]; other site 266117006950 Switch I region; other site 266117006951 G2 box; other site 266117006952 G3 box; other site 266117006953 Switch II region; other site 266117006954 G4 box; other site 266117006955 G5 box; other site 266117006956 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266117006957 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266117006958 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266117006959 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 266117006960 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266117006961 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266117006962 putative dimer interface [polypeptide binding]; other site 266117006963 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266117006964 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117006965 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266117006966 alpha subunit interface [polypeptide binding]; other site 266117006967 TPP binding site [chemical binding]; other site 266117006968 heterodimer interface [polypeptide binding]; other site 266117006969 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117006970 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266117006971 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266117006972 tetramer interface [polypeptide binding]; other site 266117006973 TPP-binding site [chemical binding]; other site 266117006974 heterodimer interface [polypeptide binding]; other site 266117006975 phosphorylation loop region [posttranslational modification] 266117006976 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266117006977 active site 266117006978 dimerization interface [polypeptide binding]; other site 266117006979 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266117006980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117006981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117006982 homodimer interface [polypeptide binding]; other site 266117006983 catalytic residue [active] 266117006984 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266117006985 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266117006986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117006987 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266117006988 Glucose inhibited division protein A; Region: GIDA; pfam01134 266117006989 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266117006990 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 266117006991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117006992 NAD(P) binding site [chemical binding]; other site 266117006993 active site 266117006994 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266117006995 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 266117006996 CoenzymeA binding site [chemical binding]; other site 266117006997 subunit interaction site [polypeptide binding]; other site 266117006998 PHB binding site; other site 266117006999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117007000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117007001 NAD(P) binding site [chemical binding]; other site 266117007002 active site 266117007003 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266117007004 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266117007005 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117007006 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266117007007 Phosphotransferase enzyme family; Region: APH; pfam01636 266117007008 putative active site [active] 266117007009 putative substrate binding site [chemical binding]; other site 266117007010 ATP binding site [chemical binding]; other site 266117007011 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 266117007012 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 266117007013 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266117007014 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266117007015 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 266117007016 acyl-activating enzyme (AAE) consensus motif; other site 266117007017 putative AMP binding site [chemical binding]; other site 266117007018 putative active site [active] 266117007019 putative CoA binding site [chemical binding]; other site 266117007020 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 266117007021 active site 266117007022 substrate binding pocket [chemical binding]; other site 266117007023 homodimer interaction site [polypeptide binding]; other site 266117007024 enoyl-CoA hydratase; Provisional; Region: PRK08140 266117007025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117007026 substrate binding site [chemical binding]; other site 266117007027 oxyanion hole (OAH) forming residues; other site 266117007028 trimer interface [polypeptide binding]; other site 266117007029 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266117007030 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266117007031 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 266117007032 acyl-activating enzyme (AAE) consensus motif; other site 266117007033 putative AMP binding site [chemical binding]; other site 266117007034 putative active site [active] 266117007035 putative CoA binding site [chemical binding]; other site 266117007036 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 266117007037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117007038 NAD(P) binding site [chemical binding]; other site 266117007039 active site 266117007040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117007041 metabolite-proton symporter; Region: 2A0106; TIGR00883 266117007042 putative substrate translocation pore; other site 266117007043 Tannase and feruloyl esterase; Region: Tannase; pfam07519 266117007044 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 266117007045 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266117007046 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266117007047 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266117007048 putative catalytic residue [active] 266117007049 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266117007050 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117007051 Sulfatase; Region: Sulfatase; pfam00884 266117007052 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 266117007053 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 266117007054 Moco binding site; other site 266117007055 metal coordination site [ion binding]; other site 266117007056 dimerization interface [polypeptide binding]; other site 266117007057 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266117007058 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266117007059 active site residue [active] 266117007060 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266117007061 active site residue [active] 266117007062 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 266117007063 active site clefts [active] 266117007064 zinc binding site [ion binding]; other site 266117007065 dimer interface [polypeptide binding]; other site 266117007066 OsmC-like protein; Region: OsmC; pfam02566 266117007067 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 266117007068 ligand-binding site [chemical binding]; other site 266117007069 Predicted transcriptional regulator [Transcription]; Region: COG1959 266117007070 Transcriptional regulator; Region: Rrf2; pfam02082 266117007071 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117007072 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117007073 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266117007074 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266117007075 dimer interface [polypeptide binding]; other site 266117007076 acyl-activating enzyme (AAE) consensus motif; other site 266117007077 putative active site [active] 266117007078 AMP binding site [chemical binding]; other site 266117007079 putative CoA binding site [chemical binding]; other site 266117007080 Predicted acyl esterases [General function prediction only]; Region: COG2936 266117007081 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 266117007082 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117007083 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 266117007084 dimer interface [polypeptide binding]; other site 266117007085 active site 266117007086 E3 Ubiquitin ligase; Region: GIDE; pfam12483 266117007087 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266117007088 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 266117007089 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 266117007090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117007091 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266117007092 SnoaL-like domain; Region: SnoaL_2; pfam12680 266117007093 Translocation protein Sec62; Region: Sec62; cl02170 266117007094 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266117007095 active site 266117007096 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266117007097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117007098 substrate binding site [chemical binding]; other site 266117007099 oxyanion hole (OAH) forming residues; other site 266117007100 trimer interface [polypeptide binding]; other site 266117007101 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266117007102 B12 binding site [chemical binding]; other site 266117007103 cobalt ligand [ion binding]; other site 266117007104 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266117007105 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266117007106 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 266117007107 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266117007108 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266117007109 Predicted membrane protein [Function unknown]; Region: COG4129 266117007110 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 266117007111 homotrimer interaction site [polypeptide binding]; other site 266117007112 putative active site [active] 266117007113 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117007114 FAD binding domain; Region: FAD_binding_4; pfam01565 266117007115 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266117007116 Cysteine-rich domain; Region: CCG; pfam02754 266117007117 Trehalase; Region: Trehalase; cl17346 266117007118 Predicted integral membrane protein [Function unknown]; Region: COG0392 266117007119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117007120 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 266117007121 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117007122 catalytic Zn binding site [ion binding]; other site 266117007123 structural Zn binding site [ion binding]; other site 266117007124 tetramer interface [polypeptide binding]; other site 266117007125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117007126 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 266117007127 NAD(P) binding site [chemical binding]; other site 266117007128 catalytic residues [active] 266117007129 catalytic residues [active] 266117007130 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 266117007131 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266117007132 putative active site [active] 266117007133 metal binding site [ion binding]; metal-binding site 266117007134 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266117007135 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266117007136 acyl-activating enzyme (AAE) consensus motif; other site 266117007137 putative AMP binding site [chemical binding]; other site 266117007138 putative active site [active] 266117007139 putative CoA binding site [chemical binding]; other site 266117007140 Predicted acyl esterases [General function prediction only]; Region: COG2936 266117007141 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 266117007142 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 266117007143 e3 binding domain; Region: E3_binding; pfam02817 266117007144 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 266117007145 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266117007146 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266117007147 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266117007148 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266117007149 acyl-coenzyme A oxidase; Region: PLN02526 266117007150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117007151 active site 266117007152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266117007153 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117007154 putative acyltransferase; Provisional; Region: PRK05790 266117007155 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117007156 dimer interface [polypeptide binding]; other site 266117007157 active site 266117007158 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266117007159 Predicted transcriptional regulators [Transcription]; Region: COG1695 266117007160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266117007161 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266117007162 homotetramer interface [polypeptide binding]; other site 266117007163 NAD(P) binding site [chemical binding]; other site 266117007164 homodimer interface [polypeptide binding]; other site 266117007165 active site 266117007166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117007167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117007168 NAD(P) binding site [chemical binding]; other site 266117007169 active site 266117007170 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266117007171 thiamine phosphate binding site [chemical binding]; other site 266117007172 active site 266117007173 pyrophosphate binding site [ion binding]; other site 266117007174 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 266117007175 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266117007176 thiS-thiF/thiG interaction site; other site 266117007177 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266117007178 ThiS interaction site; other site 266117007179 putative active site [active] 266117007180 tetramer interface [polypeptide binding]; other site 266117007181 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266117007182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117007183 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266117007184 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266117007185 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266117007186 NADP binding site [chemical binding]; other site 266117007187 dimer interface [polypeptide binding]; other site 266117007188 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117007189 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117007190 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266117007191 tetramer interface [polypeptide binding]; other site 266117007192 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266117007193 active site 266117007194 Mg2+/Mn2+ binding site [ion binding]; other site 266117007195 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 266117007196 dimer interface [polypeptide binding]; other site 266117007197 Citrate synthase; Region: Citrate_synt; pfam00285 266117007198 active site 266117007199 citrylCoA binding site [chemical binding]; other site 266117007200 oxalacetate/citrate binding site [chemical binding]; other site 266117007201 coenzyme A binding site [chemical binding]; other site 266117007202 catalytic triad [active] 266117007203 2-methylcitrate dehydratase; Region: prpD; TIGR02330 266117007204 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 266117007205 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266117007206 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266117007207 tetramer interface [polypeptide binding]; other site 266117007208 TPP-binding site [chemical binding]; other site 266117007209 heterodimer interface [polypeptide binding]; other site 266117007210 phosphorylation loop region [posttranslational modification] 266117007211 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117007212 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266117007213 alpha subunit interface [polypeptide binding]; other site 266117007214 TPP binding site [chemical binding]; other site 266117007215 heterodimer interface [polypeptide binding]; other site 266117007216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117007217 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 266117007218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266117007219 E3 interaction surface; other site 266117007220 lipoyl attachment site [posttranslational modification]; other site 266117007221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266117007222 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266117007223 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 266117007224 ATP-NAD kinase; Region: NAD_kinase; pfam01513 266117007225 Putative cyclase; Region: Cyclase; pfam04199 266117007226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117007227 benzoate transport; Region: 2A0115; TIGR00895 266117007228 putative substrate translocation pore; other site 266117007229 hypothetical protein; Provisional; Region: PRK05463 266117007230 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266117007231 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266117007232 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266117007233 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266117007234 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266117007235 MOSC domain; Region: MOSC; pfam03473 266117007236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266117007237 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 266117007238 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 266117007239 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117007240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117007241 NAD(P) binding site [chemical binding]; other site 266117007242 active site 266117007243 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266117007244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117007245 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266117007246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117007247 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266117007248 FAD binding site [chemical binding]; other site 266117007249 substrate binding site [chemical binding]; other site 266117007250 catalytic base [active] 266117007251 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 266117007252 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 266117007253 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117007254 active site 266117007255 catalytic site [active] 266117007256 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266117007257 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266117007258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117007259 dimer interface [polypeptide binding]; other site 266117007260 conserved gate region; other site 266117007261 putative PBP binding loops; other site 266117007262 ABC-ATPase subunit interface; other site 266117007263 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266117007264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117007265 dimer interface [polypeptide binding]; other site 266117007266 conserved gate region; other site 266117007267 putative PBP binding loops; other site 266117007268 ABC-ATPase subunit interface; other site 266117007269 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266117007270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266117007271 peptide binding site [polypeptide binding]; other site 266117007272 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 266117007273 Active_site [active] 266117007274 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266117007275 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 266117007276 Moco binding site; other site 266117007277 metal coordination site [ion binding]; other site 266117007278 dimerization interface [polypeptide binding]; other site 266117007279 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 266117007280 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266117007281 HIGH motif; other site 266117007282 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266117007283 active site 266117007284 KMSKS motif; other site 266117007285 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 266117007286 tRNA binding surface [nucleotide binding]; other site 266117007287 anticodon binding site; other site 266117007288 Muconolactone delta-isomerase; Region: MIase; cl01992 266117007289 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266117007290 Formamidopyrimidine-DNA glycosylase N-terminal domain; Region: Fapy_DNA_glyco; pfam01149 266117007291 DNA binding site [nucleotide binding] 266117007292 catalytic residue [active] 266117007293 H2TH interface [polypeptide binding]; other site 266117007294 putative catalytic residues [active] 266117007295 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266117007296 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266117007297 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 266117007298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117007299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266117007300 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266117007301 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266117007302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266117007303 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117007304 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 266117007305 Domain of unknown function (DUF309); Region: DUF309; pfam03745 266117007306 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266117007307 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266117007308 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266117007309 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 266117007310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117007311 Walker A motif; other site 266117007312 ATP binding site [chemical binding]; other site 266117007313 Walker B motif; other site 266117007314 arginine finger; other site 266117007315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266117007316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266117007317 catalytic residue [active] 266117007318 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266117007319 Peptidase family M23; Region: Peptidase_M23; pfam01551 266117007320 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 266117007321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117007322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117007323 short chain dehydrogenase; Provisional; Region: PRK08251 266117007324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117007325 NAD(P) binding site [chemical binding]; other site 266117007326 active site 266117007327 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266117007328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117007329 substrate binding site [chemical binding]; other site 266117007330 oxyanion hole (OAH) forming residues; other site 266117007331 trimer interface [polypeptide binding]; other site 266117007332 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266117007333 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117007334 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266117007335 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 266117007336 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117007337 dimer interface [polypeptide binding]; other site 266117007338 active site 266117007339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117007340 acyl-coenzyme A oxidase; Region: PLN02526 266117007341 active site 266117007342 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 266117007343 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117007344 NAD(P) binding site [chemical binding]; other site 266117007345 catalytic residues [active] 266117007346 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 266117007347 putative NAD(P) binding site [chemical binding]; other site 266117007348 homodimer interface [polypeptide binding]; other site 266117007349 active site 266117007350 substrate binding site [chemical binding]; other site 266117007351 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 266117007352 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 266117007353 acyl-activating enzyme (AAE) consensus motif; other site 266117007354 putative AMP binding site [chemical binding]; other site 266117007355 putative active site [active] 266117007356 putative CoA binding site [chemical binding]; other site 266117007357 SCP-2 sterol transfer family; Region: SCP2; pfam02036 266117007358 Bifunctional nuclease; Region: DNase-RNase; pfam02577 266117007359 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266117007360 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266117007361 DNA interaction; other site 266117007362 Metal-binding active site; metal-binding site 266117007363 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266117007364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266117007365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117007366 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266117007367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266117007368 carboxyltransferase (CT) interaction site; other site 266117007369 biotinylation site [posttranslational modification]; other site 266117007370 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 266117007371 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266117007372 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266117007373 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 266117007374 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266117007375 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 266117007376 NAD binding site [chemical binding]; other site 266117007377 Phe binding site; other site 266117007378 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 266117007379 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266117007380 intersubunit interface [polypeptide binding]; other site 266117007381 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266117007382 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266117007383 active site 266117007384 ATP-binding site [chemical binding]; other site 266117007385 pantoate-binding site; other site 266117007386 HXXH motif; other site 266117007387 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 266117007388 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266117007389 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117007390 Walker A/P-loop; other site 266117007391 ATP binding site [chemical binding]; other site 266117007392 Q-loop/lid; other site 266117007393 ABC transporter signature motif; other site 266117007394 Walker B; other site 266117007395 D-loop; other site 266117007396 H-loop/switch region; other site 266117007397 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 266117007398 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266117007399 Walker A/P-loop; other site 266117007400 ATP binding site [chemical binding]; other site 266117007401 Q-loop/lid; other site 266117007402 ABC transporter signature motif; other site 266117007403 Walker B; other site 266117007404 D-loop; other site 266117007405 H-loop/switch region; other site 266117007406 Predicted membrane protein [Function unknown]; Region: COG4684 266117007407 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 266117007408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117007409 classical (c) SDRs; Region: SDR_c; cd05233 266117007410 NAD(P) binding site [chemical binding]; other site 266117007411 active site 266117007412 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266117007413 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 266117007414 metal binding site [ion binding]; metal-binding site 266117007415 dimer interface [polypeptide binding]; other site 266117007416 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266117007417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117007418 putative substrate translocation pore; other site 266117007419 thiamine pyrophosphate protein; Validated; Region: PRK08199 266117007420 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117007421 PYR/PP interface [polypeptide binding]; other site 266117007422 dimer interface [polypeptide binding]; other site 266117007423 TPP binding site [chemical binding]; other site 266117007424 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117007425 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266117007426 TPP-binding site [chemical binding]; other site 266117007427 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266117007428 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266117007429 E3 interaction surface; other site 266117007430 lipoyl attachment site [posttranslational modification]; other site 266117007431 e3 binding domain; Region: E3_binding; pfam02817 266117007432 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266117007433 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117007434 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266117007435 alpha subunit interface [polypeptide binding]; other site 266117007436 TPP binding site [chemical binding]; other site 266117007437 heterodimer interface [polypeptide binding]; other site 266117007438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117007439 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266117007440 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266117007441 tetramer interface [polypeptide binding]; other site 266117007442 TPP-binding site [chemical binding]; other site 266117007443 heterodimer interface [polypeptide binding]; other site 266117007444 phosphorylation loop region [posttranslational modification] 266117007445 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 266117007446 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117007447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117007448 active site 266117007449 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 266117007450 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 266117007451 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266117007452 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266117007453 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117007454 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 266117007455 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266117007456 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266117007457 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266117007458 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117007459 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266117007460 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 266117007461 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266117007462 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 266117007463 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 266117007464 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 266117007465 putative active site [active] 266117007466 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 266117007467 domain_subunit interface; other site 266117007468 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266117007469 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 266117007470 active site 266117007471 FMN binding site [chemical binding]; other site 266117007472 substrate binding site [chemical binding]; other site 266117007473 3Fe-4S cluster binding site [ion binding]; other site 266117007474 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266117007475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117007476 non-specific DNA binding site [nucleotide binding]; other site 266117007477 salt bridge; other site 266117007478 sequence-specific DNA binding site [nucleotide binding]; other site 266117007479 Cupin domain; Region: Cupin_2; pfam07883 266117007480 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266117007481 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266117007482 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266117007483 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 266117007484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266117007485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007486 phosphorylation site [posttranslational modification] 266117007487 intermolecular recognition site; other site 266117007488 PAS domain; Region: PAS_9; pfam13426 266117007489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117007490 putative active site [active] 266117007491 heme pocket [chemical binding]; other site 266117007492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117007493 Histidine kinase; Region: HisKA_3; pfam07730 266117007494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117007495 ATP binding site [chemical binding]; other site 266117007496 Mg2+ binding site [ion binding]; other site 266117007497 G-X-G motif; other site 266117007498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117007499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007500 active site 266117007501 phosphorylation site [posttranslational modification] 266117007502 intermolecular recognition site; other site 266117007503 dimerization interface [polypeptide binding]; other site 266117007504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117007505 DNA binding residues [nucleotide binding] 266117007506 dimerization interface [polypeptide binding]; other site 266117007507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266117007508 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266117007509 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266117007510 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 266117007511 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266117007512 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266117007513 homodimer interface [polypeptide binding]; other site 266117007514 NADP binding site [chemical binding]; other site 266117007515 substrate binding site [chemical binding]; other site 266117007516 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 266117007517 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266117007518 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266117007519 Potassium binding sites [ion binding]; other site 266117007520 Cesium cation binding sites [ion binding]; other site 266117007521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117007522 Ligand Binding Site [chemical binding]; other site 266117007523 ethanolamine permease; Region: 2A0305; TIGR00908 266117007524 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266117007525 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266117007526 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 266117007527 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 266117007528 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266117007529 dimer interface [polypeptide binding]; other site 266117007530 active site 266117007531 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266117007532 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 266117007533 active site 266117007534 acyl-activating enzyme (AAE) consensus motif; other site 266117007535 putative CoA binding site [chemical binding]; other site 266117007536 AMP binding site [chemical binding]; other site 266117007537 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266117007538 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266117007539 intersubunit interface [polypeptide binding]; other site 266117007540 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117007541 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117007542 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266117007543 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266117007544 E3 interaction surface; other site 266117007545 lipoyl attachment site [posttranslational modification]; other site 266117007546 e3 binding domain; Region: E3_binding; pfam02817 266117007547 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266117007548 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266117007549 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266117007550 TPP-binding site [chemical binding]; other site 266117007551 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266117007552 dimer interface [polypeptide binding]; other site 266117007553 PYR/PP interface [polypeptide binding]; other site 266117007554 TPP binding site [chemical binding]; other site 266117007555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266117007556 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266117007557 binding surface 266117007558 TPR motif; other site 266117007559 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 266117007560 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266117007561 homodimer interface [polypeptide binding]; other site 266117007562 substrate-cofactor binding pocket; other site 266117007563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117007564 catalytic residue [active] 266117007565 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 266117007566 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 266117007567 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 266117007568 Zn binding site [ion binding]; other site 266117007569 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266117007570 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 266117007571 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266117007572 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 266117007573 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 266117007574 catalytic residues [active] 266117007575 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 266117007576 active site 266117007577 intersubunit interface [polypeptide binding]; other site 266117007578 catalytic residue [active] 266117007579 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117007580 active site 266117007581 catalytic site [active] 266117007582 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266117007583 CoA binding domain; Region: CoA_binding; smart00881 266117007584 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266117007585 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266117007586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266117007587 CCC1-related family of proteins; Region: CCC1_like; cl00278 266117007588 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266117007589 lipoyl synthase; Provisional; Region: PRK05481 266117007590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117007591 FeS/SAM binding site; other site 266117007592 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 266117007593 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266117007594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117007595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266117007596 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266117007597 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266117007598 DNA binding site [nucleotide binding] 266117007599 catalytic residue [active] 266117007600 H2TH interface [polypeptide binding]; other site 266117007601 putative catalytic residues [active] 266117007602 turnover-facilitating residue; other site 266117007603 8OG recognition residue [nucleotide binding]; other site 266117007604 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266117007605 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266117007606 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266117007607 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266117007608 MoaE interaction surface [polypeptide binding]; other site 266117007609 MoeB interaction surface [polypeptide binding]; other site 266117007610 thiocarboxylated glycine; other site 266117007611 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266117007612 MoaE homodimer interface [polypeptide binding]; other site 266117007613 MoaD interaction [polypeptide binding]; other site 266117007614 active site residues [active] 266117007615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266117007616 nudix motif; other site 266117007617 Helix-turn-helix domain; Region: HTH_17; pfam12728 266117007618 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266117007619 dimer interface [polypeptide binding]; other site 266117007620 Citrate synthase; Region: Citrate_synt; pfam00285 266117007621 active site 266117007622 oxalacetate/citrate binding site [chemical binding]; other site 266117007623 citrylCoA binding site [chemical binding]; other site 266117007624 coenzyme A binding site [chemical binding]; other site 266117007625 catalytic triad [active] 266117007626 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 266117007627 dimer interface [polypeptide binding]; other site 266117007628 Citrate synthase; Region: Citrate_synt; pfam00285 266117007629 active site 266117007630 citrylCoA binding site [chemical binding]; other site 266117007631 oxalacetate/citrate binding site [chemical binding]; other site 266117007632 coenzyme A binding site [chemical binding]; other site 266117007633 catalytic triad [active] 266117007634 competence damage-inducible protein A; Provisional; Region: PRK00549 266117007635 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266117007636 putative MPT binding site; other site 266117007637 Competence-damaged protein; Region: CinA; pfam02464 266117007638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266117007639 Zn2+ binding site [ion binding]; other site 266117007640 Mg2+ binding site [ion binding]; other site 266117007641 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 266117007642 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 266117007643 Protein of unknown function, DUF488; Region: DUF488; cl01246 266117007644 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 266117007645 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266117007646 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266117007647 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266117007648 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266117007649 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266117007650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117007651 active site residue [active] 266117007652 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 266117007653 nucleotide binding site/active site [active] 266117007654 HIT family signature motif; other site 266117007655 catalytic residue [active] 266117007656 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 266117007657 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266117007658 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266117007659 histidinol-phosphatase; Provisional; Region: PRK07328 266117007660 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 266117007661 active site 266117007662 dimer interface [polypeptide binding]; other site 266117007663 calcium/proton exchanger (cax); Region: cax; TIGR00378 266117007664 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266117007665 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266117007666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117007667 S-adenosylmethionine binding site [chemical binding]; other site 266117007668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117007669 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117007670 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266117007671 active site 266117007672 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 266117007673 putative NAD(P) binding site [chemical binding]; other site 266117007674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117007675 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 266117007676 RibD C-terminal domain; Region: RibD_C; cl17279 266117007677 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 266117007678 homooctamer interface [polypeptide binding]; other site 266117007679 active site 266117007680 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 266117007681 putative acyl-acceptor binding pocket; other site 266117007682 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 266117007683 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117007684 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266117007685 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117007686 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266117007687 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266117007688 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 266117007689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117007690 dimer interface [polypeptide binding]; other site 266117007691 conserved gate region; other site 266117007692 ABC-ATPase subunit interface; other site 266117007693 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266117007694 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 266117007695 Walker A/P-loop; other site 266117007696 ATP binding site [chemical binding]; other site 266117007697 Q-loop/lid; other site 266117007698 ABC transporter signature motif; other site 266117007699 Walker B; other site 266117007700 D-loop; other site 266117007701 H-loop/switch region; other site 266117007702 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266117007703 alpha-glucosidase; Provisional; Region: PRK10426 266117007704 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 266117007705 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 266117007706 putative active site [active] 266117007707 putative catalytic site [active] 266117007708 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 266117007709 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 266117007710 hexamer (dimer of trimers) interface [polypeptide binding]; other site 266117007711 substrate binding site [chemical binding]; other site 266117007712 trimer interface [polypeptide binding]; other site 266117007713 Mn binding site [ion binding]; other site 266117007714 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 266117007715 active site 266117007716 ADP/pyrophosphate binding site [chemical binding]; other site 266117007717 dimerization interface [polypeptide binding]; other site 266117007718 allosteric effector site; other site 266117007719 fructose-1,6-bisphosphate binding site; other site 266117007720 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117007721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117007722 DNA-binding site [nucleotide binding]; DNA binding site 266117007723 FCD domain; Region: FCD; pfam07729 266117007724 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266117007725 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266117007726 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266117007727 Uncharacterized conserved protein [Function unknown]; Region: COG0327 266117007728 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 266117007729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 266117007730 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 266117007731 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266117007732 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117007733 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 266117007734 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 266117007735 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 266117007736 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 266117007737 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 266117007738 Pleckstrin homology-like domain; Region: PH-like; cl17171 266117007739 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266117007740 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266117007741 Sad1 / UNC-like C-terminal; Region: Sad1_UNC; pfam07738 266117007742 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 266117007743 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 266117007744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266117007745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266117007746 DNA binding site [nucleotide binding] 266117007747 domain linker motif; other site 266117007748 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266117007749 dimerization interface [polypeptide binding]; other site 266117007750 ligand binding site [chemical binding]; other site 266117007751 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266117007752 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117007753 Walker A/P-loop; other site 266117007754 ATP binding site [chemical binding]; other site 266117007755 Q-loop/lid; other site 266117007756 ABC transporter signature motif; other site 266117007757 Walker B; other site 266117007758 D-loop; other site 266117007759 H-loop/switch region; other site 266117007760 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117007761 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117007762 TM-ABC transporter signature motif; other site 266117007763 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266117007764 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117007765 putative ligand binding site [chemical binding]; other site 266117007766 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266117007767 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266117007768 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 266117007769 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 266117007770 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 266117007771 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266117007772 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266117007773 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117007774 Ligand Binding Site [chemical binding]; other site 266117007775 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266117007776 GAF domain; Region: GAF_3; pfam13492 266117007777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117007778 Histidine kinase; Region: HisKA_3; pfam07730 266117007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117007780 Mg2+ binding site [ion binding]; other site 266117007781 G-X-G motif; other site 266117007782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007784 active site 266117007785 phosphorylation site [posttranslational modification] 266117007786 intermolecular recognition site; other site 266117007787 dimerization interface [polypeptide binding]; other site 266117007788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117007789 DNA binding residues [nucleotide binding] 266117007790 dimerization interface [polypeptide binding]; other site 266117007791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117007792 short chain dehydrogenase; Provisional; Region: PRK07326 266117007793 classical (c) SDRs; Region: SDR_c; cd05233 266117007794 NAD(P) binding site [chemical binding]; other site 266117007795 active site 266117007796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117007797 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266117007798 active site 266117007799 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266117007800 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 266117007801 Predicted transcriptional regulator [Transcription]; Region: COG1959 266117007802 Transcriptional regulator; Region: Rrf2; pfam02082 266117007803 Cupin domain; Region: Cupin_2; pfam07883 266117007804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117007805 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266117007806 Protein of unknown function DUF82; Region: DUF82; pfam01927 266117007807 Uncharacterized conserved protein [Function unknown]; Region: COG1656 266117007808 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266117007809 trimer interface [polypeptide binding]; other site 266117007810 active site 266117007811 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 266117007812 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 266117007813 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 266117007814 NodB motif; other site 266117007815 putative active site [active] 266117007816 putative catalytic site [active] 266117007817 putative Zn binding site [ion binding]; other site 266117007818 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 266117007819 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 266117007820 active site 266117007821 homodimer interface [polypeptide binding]; other site 266117007822 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266117007823 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 266117007824 DXD motif; other site 266117007825 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 266117007826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117007827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007828 active site 266117007829 phosphorylation site [posttranslational modification] 266117007830 intermolecular recognition site; other site 266117007831 dimerization interface [polypeptide binding]; other site 266117007832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117007833 DNA binding residues [nucleotide binding] 266117007834 dimerization interface [polypeptide binding]; other site 266117007835 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 266117007836 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266117007837 active site 266117007838 HIGH motif; other site 266117007839 KMSKS motif; other site 266117007840 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266117007841 tRNA binding surface [nucleotide binding]; other site 266117007842 anticodon binding site; other site 266117007843 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117007844 active site residue [active] 266117007845 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 266117007846 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 266117007847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266117007848 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266117007849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266117007850 DNA binding residues [nucleotide binding] 266117007851 transcription factor E; Region: TIGR00373 266117007852 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 266117007853 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266117007854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266117007855 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266117007856 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 266117007857 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 266117007858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266117007859 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266117007860 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266117007861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266117007862 Putative cyclase; Region: Cyclase; pfam04199 266117007863 Predicted membrane protein [Function unknown]; Region: COG2860 266117007864 UPF0126 domain; Region: UPF0126; pfam03458 266117007865 UPF0126 domain; Region: UPF0126; pfam03458 266117007866 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266117007867 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266117007868 Walker A/P-loop; other site 266117007869 ATP binding site [chemical binding]; other site 266117007870 Q-loop/lid; other site 266117007871 ABC transporter signature motif; other site 266117007872 Walker B; other site 266117007873 D-loop; other site 266117007874 H-loop/switch region; other site 266117007875 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266117007876 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266117007877 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266117007878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266117007879 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266117007880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117007881 dimer interface [polypeptide binding]; other site 266117007882 conserved gate region; other site 266117007883 putative PBP binding loops; other site 266117007884 ABC-ATPase subunit interface; other site 266117007885 amphi-Trp domain; Region: amphi-Trp; TIGR04354 266117007886 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 266117007887 Domain of unknown function DUF59; Region: DUF59; cl00941 266117007888 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266117007889 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 266117007890 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 266117007891 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 266117007892 PAS fold; Region: PAS; pfam00989 266117007893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117007894 putative active site [active] 266117007895 heme pocket [chemical binding]; other site 266117007896 PAS fold; Region: PAS; pfam00989 266117007897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117007898 putative active site [active] 266117007899 heme pocket [chemical binding]; other site 266117007900 PAS fold; Region: PAS_4; pfam08448 266117007901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266117007902 putative active site [active] 266117007903 heme pocket [chemical binding]; other site 266117007904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117007905 putative active site [active] 266117007906 PAS fold; Region: PAS_3; pfam08447 266117007907 heme pocket [chemical binding]; other site 266117007908 PAS domain S-box; Region: sensory_box; TIGR00229 266117007909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117007910 putative active site [active] 266117007911 heme pocket [chemical binding]; other site 266117007912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117007913 dimer interface [polypeptide binding]; other site 266117007914 phosphorylation site [posttranslational modification] 266117007915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117007916 ATP binding site [chemical binding]; other site 266117007917 Mg2+ binding site [ion binding]; other site 266117007918 G-X-G motif; other site 266117007919 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266117007920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007921 active site 266117007922 phosphorylation site [posttranslational modification] 266117007923 intermolecular recognition site; other site 266117007924 dimerization interface [polypeptide binding]; other site 266117007925 Response regulator receiver domain; Region: Response_reg; pfam00072 266117007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007927 active site 266117007928 phosphorylation site [posttranslational modification] 266117007929 intermolecular recognition site; other site 266117007930 dimerization interface [polypeptide binding]; other site 266117007931 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266117007932 putative binding surface; other site 266117007933 active site 266117007934 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266117007935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117007936 ATP binding site [chemical binding]; other site 266117007937 Mg2+ binding site [ion binding]; other site 266117007938 G-X-G motif; other site 266117007939 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266117007940 anti sigma factor interaction site; other site 266117007941 regulatory phosphorylation site [posttranslational modification]; other site 266117007942 GAF domain; Region: GAF_3; pfam13492 266117007943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117007944 metal binding site [ion binding]; metal-binding site 266117007945 I-site; other site 266117007946 HEAT repeats; Region: HEAT_2; pfam13646 266117007947 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 266117007948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117007949 Predicted membrane protein [Function unknown]; Region: COG4267 266117007950 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266117007951 anti sigma factor interaction site; other site 266117007952 regulatory phosphorylation site [posttranslational modification]; other site 266117007953 Spherulation-specific family 4; Region: Spherulin4; pfam12138 266117007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117007955 Response regulator receiver domain; Region: Response_reg; pfam00072 266117007956 active site 266117007957 phosphorylation site [posttranslational modification] 266117007958 intermolecular recognition site; other site 266117007959 dimerization interface [polypeptide binding]; other site 266117007960 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 266117007961 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266117007962 aspartate aminotransferase; Provisional; Region: PRK05764 266117007963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266117007964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117007965 homodimer interface [polypeptide binding]; other site 266117007966 catalytic residue [active] 266117007967 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266117007968 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266117007969 minor groove reading motif; other site 266117007970 helix-hairpin-helix signature motif; other site 266117007971 substrate binding pocket [chemical binding]; other site 266117007972 active site 266117007973 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 266117007974 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 266117007975 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266117007976 active site 266117007977 dimer interface [polypeptide binding]; other site 266117007978 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266117007979 dimer interface [polypeptide binding]; other site 266117007980 active site 266117007981 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266117007982 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 266117007983 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266117007984 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 266117007985 Moco binding site; other site 266117007986 metal coordination site [ion binding]; other site 266117007987 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266117007988 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266117007989 Sulfatase; Region: Sulfatase; cl17466 266117007990 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117007991 Predicted transcriptional regulators [Transcription]; Region: COG1695 266117007992 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266117007993 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266117007994 Chromate transporter; Region: Chromate_transp; pfam02417 266117007995 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 266117007996 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266117007997 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266117007998 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 266117007999 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 266117008000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117008001 putative homodimer interface [polypeptide binding]; other site 266117008002 O-Antigen ligase; Region: Wzy_C; pfam04932 266117008003 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 266117008004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117008005 TPR motif; other site 266117008006 binding surface 266117008007 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266117008008 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266117008009 conserved hypothetical protein; Region: TIGR02246 266117008010 SnoaL-like domain; Region: SnoaL_3; pfam13474 266117008011 Predicted transcriptional regulators [Transcription]; Region: COG1695 266117008012 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266117008013 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266117008014 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266117008015 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266117008016 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266117008017 Qi binding site; other site 266117008018 intrachain domain interface; other site 266117008019 interchain domain interface [polypeptide binding]; other site 266117008020 heme bH binding site [chemical binding]; other site 266117008021 heme bL binding site [chemical binding]; other site 266117008022 Qo binding site; other site 266117008023 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266117008024 iron-sulfur cluster [ion binding]; other site 266117008025 [2Fe-2S] cluster binding site [ion binding]; other site 266117008026 benzoate transport; Region: 2A0115; TIGR00895 266117008027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117008030 Ligand Binding Site [chemical binding]; other site 266117008031 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 266117008032 thiamine pyrophosphate protein; Provisional; Region: PRK08273 266117008033 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266117008034 PYR/PP interface [polypeptide binding]; other site 266117008035 dimer interface [polypeptide binding]; other site 266117008036 tetramer interface [polypeptide binding]; other site 266117008037 TPP binding site [chemical binding]; other site 266117008038 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117008039 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266117008040 TPP-binding site [chemical binding]; other site 266117008041 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 266117008042 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117008043 putative active site pocket [active] 266117008044 putative metal binding site [ion binding]; other site 266117008045 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117008046 FAD binding domain; Region: FAD_binding_4; pfam01565 266117008047 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266117008048 Cysteine-rich domain; Region: CCG; pfam02754 266117008049 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 266117008050 trimer interface [polypeptide binding]; other site 266117008051 putative Zn binding site [ion binding]; other site 266117008052 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 266117008053 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117008054 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117008055 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117008056 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266117008057 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 266117008058 molybdopterin cofactor binding site; other site 266117008059 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 266117008060 4Fe-4S binding domain; Region: Fer4; pfam00037 266117008061 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 266117008062 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 266117008063 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266117008064 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 266117008065 Moco binding site; other site 266117008066 metal coordination site [ion binding]; other site 266117008067 HPP family; Region: HPP; pfam04982 266117008068 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266117008069 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266117008070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266117008071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266117008072 active site 266117008073 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266117008074 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266117008075 putative active site [active] 266117008076 putative catalytic site [active] 266117008077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117008078 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117008079 DNA-binding site [nucleotide binding]; DNA binding site 266117008080 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266117008081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008082 benzoate transport; Region: 2A0115; TIGR00895 266117008083 putative substrate translocation pore; other site 266117008084 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266117008085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117008086 NAD(P) binding site [chemical binding]; other site 266117008087 active site 266117008088 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266117008089 active site 266117008090 homodimer interface [polypeptide binding]; other site 266117008091 homotetramer interface [polypeptide binding]; other site 266117008092 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 266117008093 active site 266117008094 catalytic site [active] 266117008095 Zn binding site [ion binding]; other site 266117008096 tetramer interface [polypeptide binding]; other site 266117008097 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266117008098 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266117008099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266117008100 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266117008101 allantoate amidohydrolase; Reviewed; Region: PRK09290 266117008102 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266117008103 active site 266117008104 metal binding site [ion binding]; metal-binding site 266117008105 dimer interface [polypeptide binding]; other site 266117008106 phenylhydantoinase; Validated; Region: PRK08323 266117008107 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266117008108 tetramer interface [polypeptide binding]; other site 266117008109 active site 266117008110 Isochorismatase family; Region: Isochorismatase; pfam00857 266117008111 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266117008112 catalytic triad [active] 266117008113 conserved cis-peptide bond; other site 266117008114 fumarate hydratase; Provisional; Region: PRK06246 266117008115 Fumarase C-terminus; Region: Fumerase_C; pfam05683 266117008116 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266117008117 short chain dehydrogenase; Provisional; Region: PRK07109 266117008118 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 266117008119 putative NAD(P) binding site [chemical binding]; other site 266117008120 active site 266117008121 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 266117008122 putative active site [active] 266117008123 redox center [active] 266117008124 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266117008125 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266117008126 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266117008127 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266117008128 substrate binding pocket [chemical binding]; other site 266117008129 chain length determination region; other site 266117008130 substrate-Mg2+ binding site; other site 266117008131 catalytic residues [active] 266117008132 aspartate-rich region 1; other site 266117008133 active site lid residues [active] 266117008134 aspartate-rich region 2; other site 266117008135 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 266117008136 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 266117008137 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 266117008138 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 266117008139 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 266117008140 UbiA prenyltransferase family; Region: UbiA; pfam01040 266117008141 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266117008142 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266117008143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117008144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117008145 active site 266117008146 catalytic tetrad [active] 266117008147 NAD synthetase; Provisional; Region: PRK13981 266117008148 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266117008149 multimer interface [polypeptide binding]; other site 266117008150 active site 266117008151 catalytic triad [active] 266117008152 protein interface 1 [polypeptide binding]; other site 266117008153 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266117008154 homodimer interface [polypeptide binding]; other site 266117008155 NAD binding pocket [chemical binding]; other site 266117008156 ATP binding pocket [chemical binding]; other site 266117008157 Mg binding site [ion binding]; other site 266117008158 active-site loop [active] 266117008159 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 266117008160 nudix motif; other site 266117008161 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266117008162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266117008163 NAD binding site [chemical binding]; other site 266117008164 ligand binding site [chemical binding]; other site 266117008165 catalytic site [active] 266117008166 Domain of unknown function DUF21; Region: DUF21; pfam01595 266117008167 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266117008168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266117008169 Transporter associated domain; Region: CorC_HlyC; smart01091 266117008170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266117008171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266117008172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266117008173 Walker A/P-loop; other site 266117008174 ATP binding site [chemical binding]; other site 266117008175 Q-loop/lid; other site 266117008176 ABC transporter signature motif; other site 266117008177 Walker B; other site 266117008178 D-loop; other site 266117008179 H-loop/switch region; other site 266117008180 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266117008181 dimer interface [polypeptide binding]; other site 266117008182 ADP-ribose binding site [chemical binding]; other site 266117008183 active site 266117008184 nudix motif; other site 266117008185 metal binding site [ion binding]; metal-binding site 266117008186 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 266117008187 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266117008188 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266117008189 Protein of unknown function DUF58; Region: DUF58; pfam01882 266117008190 MoxR-like ATPases [General function prediction only]; Region: COG0714 266117008191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117008192 Walker A motif; other site 266117008193 ATP binding site [chemical binding]; other site 266117008194 Walker B motif; other site 266117008195 arginine finger; other site 266117008196 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266117008197 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266117008198 active site 266117008199 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 266117008200 Ferritin-like domain; Region: Ferritin; pfam00210 266117008201 ferroxidase diiron center [ion binding]; other site 266117008202 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 266117008203 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117008204 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266117008205 metal binding site [ion binding]; metal-binding site 266117008206 substrate binding pocket [chemical binding]; other site 266117008207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117008208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117008209 active site 266117008210 phosphorylation site [posttranslational modification] 266117008211 intermolecular recognition site; other site 266117008212 dimerization interface [polypeptide binding]; other site 266117008213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117008214 DNA binding site [nucleotide binding] 266117008215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117008216 dimer interface [polypeptide binding]; other site 266117008217 phosphorylation site [posttranslational modification] 266117008218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117008219 ATP binding site [chemical binding]; other site 266117008220 Mg2+ binding site [ion binding]; other site 266117008221 G-X-G motif; other site 266117008222 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266117008223 PAS fold; Region: PAS_4; pfam08448 266117008224 PAS fold; Region: PAS_4; pfam08448 266117008225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117008226 putative active site [active] 266117008227 heme pocket [chemical binding]; other site 266117008228 PAS domain; Region: PAS_9; pfam13426 266117008229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117008230 putative active site [active] 266117008231 heme pocket [chemical binding]; other site 266117008232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117008233 PAS fold; Region: PAS_3; pfam08447 266117008234 putative active site [active] 266117008235 heme pocket [chemical binding]; other site 266117008236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266117008237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266117008238 metal binding site [ion binding]; metal-binding site 266117008239 active site 266117008240 I-site; other site 266117008241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266117008242 Putative transcription activator [Transcription]; Region: TenA; COG0819 266117008243 ChaB; Region: ChaB; pfam06150 266117008244 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 266117008245 ATP binding site [chemical binding]; other site 266117008246 dimerization interface [polypeptide binding]; other site 266117008247 thiamine monophosphate kinase; Provisional; Region: PRK05731 266117008248 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266117008249 nudix motif; other site 266117008250 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 266117008251 nudix motif; other site 266117008252 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266117008253 thiamine phosphate binding site [chemical binding]; other site 266117008254 active site 266117008255 pyrophosphate binding site [ion binding]; other site 266117008256 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 266117008257 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 266117008258 substrate binding site [chemical binding]; other site 266117008259 multimerization interface [polypeptide binding]; other site 266117008260 ATP binding site [chemical binding]; other site 266117008261 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266117008262 dimer interface [polypeptide binding]; other site 266117008263 substrate binding site [chemical binding]; other site 266117008264 ATP binding site [chemical binding]; other site 266117008265 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266117008266 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 266117008267 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266117008268 dimer interface [polypeptide binding]; other site 266117008269 ADP-ribose binding site [chemical binding]; other site 266117008270 active site 266117008271 nudix motif; other site 266117008272 metal binding site [ion binding]; metal-binding site 266117008273 Ferredoxin [Energy production and conversion]; Region: COG1146 266117008274 4Fe-4S binding domain; Region: Fer4; cl02805 266117008275 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266117008276 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266117008277 ligand binding site [chemical binding]; other site 266117008278 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266117008279 putative switch regulator; other site 266117008280 non-specific DNA interactions [nucleotide binding]; other site 266117008281 DNA binding site [nucleotide binding] 266117008282 sequence specific DNA binding site [nucleotide binding]; other site 266117008283 putative cAMP binding site [chemical binding]; other site 266117008284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008285 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266117008286 putative substrate translocation pore; other site 266117008287 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 266117008288 classical (c) SDRs; Region: SDR_c; cd05233 266117008289 NAD(P) binding site [chemical binding]; other site 266117008290 active site 266117008291 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117008292 active site 266117008293 catalytic site [active] 266117008294 amino acid transporter; Region: 2A0306; TIGR00909 266117008295 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266117008296 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266117008297 active site residue [active] 266117008298 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266117008299 active site residue [active] 266117008300 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 266117008301 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266117008302 active site 266117008303 NTP binding site [chemical binding]; other site 266117008304 metal binding triad [ion binding]; metal-binding site 266117008305 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266117008306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 266117008307 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 266117008308 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266117008309 anti sigma factor interaction site; other site 266117008310 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266117008311 regulatory phosphorylation site [posttranslational modification]; other site 266117008312 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266117008313 LabA_like proteins; Region: LabA; cd10911 266117008314 putative metal binding site [ion binding]; other site 266117008315 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 266117008316 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 266117008317 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 266117008318 Ligand Binding Site [chemical binding]; other site 266117008319 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117008320 active site residue [active] 266117008321 UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179 266117008322 FAD binding domain; Region: FAD_binding_4; pfam01565 266117008323 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266117008324 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266117008325 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 266117008326 active site 266117008327 Substrate binding site; other site 266117008328 Mg++ binding site; other site 266117008329 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266117008330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117008331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117008332 active site 266117008333 phosphorylation site [posttranslational modification] 266117008334 intermolecular recognition site; other site 266117008335 dimerization interface [polypeptide binding]; other site 266117008336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117008337 DNA binding residues [nucleotide binding] 266117008338 dimerization interface [polypeptide binding]; other site 266117008339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266117008340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266117008341 dimerization interface [polypeptide binding]; other site 266117008342 Histidine kinase; Region: HisKA_3; pfam07730 266117008343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117008344 ATP binding site [chemical binding]; other site 266117008345 Mg2+ binding site [ion binding]; other site 266117008346 G-X-G motif; other site 266117008347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117008348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117008349 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266117008350 Tic20-like protein; Region: Tic20; pfam09685 266117008351 lipoprotein signal peptidase; Provisional; Region: PRK14787 266117008352 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 266117008353 Predicted transcriptional regulator [Transcription]; Region: COG2345 266117008354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117008355 putative DNA binding site [nucleotide binding]; other site 266117008356 putative Zn2+ binding site [ion binding]; other site 266117008357 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 266117008358 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266117008359 [2Fe-2S] cluster binding site [ion binding]; other site 266117008360 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266117008361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266117008362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117008363 aconitate hydratase; Validated; Region: PRK07229 266117008364 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 266117008365 substrate binding site [chemical binding]; other site 266117008366 ligand binding site [chemical binding]; other site 266117008367 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 266117008368 substrate binding site [chemical binding]; other site 266117008369 thymidine kinase; Provisional; Region: PRK04296 266117008370 Uncharacterized conserved protein [Function unknown]; Region: COG0398 266117008371 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266117008372 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266117008373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266117008374 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266117008375 Cysteine-rich domain; Region: CCG; pfam02754 266117008376 Cysteine-rich domain; Region: CCG; pfam02754 266117008377 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117008378 FAD binding domain; Region: FAD_binding_4; pfam01565 266117008379 FAD binding domain; Region: FAD_binding_4; pfam01565 266117008380 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 266117008381 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 266117008382 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266117008383 Na binding site [ion binding]; other site 266117008384 putative substrate binding site [chemical binding]; other site 266117008385 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266117008386 active site 266117008387 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266117008388 FAD binding domain; Region: FAD_binding_4; pfam01565 266117008389 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266117008390 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266117008391 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266117008392 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 266117008393 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266117008394 active site 266117008395 putative substrate binding pocket [chemical binding]; other site 266117008396 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 266117008397 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266117008398 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266117008399 xanthine permease; Region: pbuX; TIGR03173 266117008400 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 266117008401 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266117008402 nucleoside/Zn binding site; other site 266117008403 dimer interface [polypeptide binding]; other site 266117008404 catalytic motif [active] 266117008405 urate oxidase; Region: urate_oxi; TIGR03383 266117008406 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266117008407 active site 266117008408 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266117008409 active site 266117008410 homotetramer interface [polypeptide binding]; other site 266117008411 allantoinase; Provisional; Region: PRK06189 266117008412 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 266117008413 active site 266117008414 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 266117008415 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 266117008416 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266117008417 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266117008418 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 266117008419 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 266117008420 putative substrate binding site [chemical binding]; other site 266117008421 nucleotide binding site [chemical binding]; other site 266117008422 nucleotide binding site [chemical binding]; other site 266117008423 homodimer interface [polypeptide binding]; other site 266117008424 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266117008425 active site 266117008426 homotetramer interface [polypeptide binding]; other site 266117008427 homodimer interface [polypeptide binding]; other site 266117008428 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266117008429 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266117008430 Bacterial transcriptional regulator; Region: IclR; pfam01614 266117008431 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266117008432 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266117008433 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266117008434 glyoxylate carboligase; Provisional; Region: PRK11269 266117008435 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117008436 PYR/PP interface [polypeptide binding]; other site 266117008437 dimer interface [polypeptide binding]; other site 266117008438 TPP binding site [chemical binding]; other site 266117008439 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117008440 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266117008441 TPP-binding site [chemical binding]; other site 266117008442 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266117008443 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266117008444 MOFRL family; Region: MOFRL; pfam05161 266117008445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117008446 active site 266117008447 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266117008448 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266117008449 HIGH motif; other site 266117008450 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266117008451 active site 266117008452 KMSKS motif; other site 266117008453 NifU-like domain; Region: NifU; cl00484 266117008454 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266117008455 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 266117008456 active site 266117008457 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266117008458 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266117008459 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266117008460 Class II fumarases; Region: Fumarase_classII; cd01362 266117008461 active site 266117008462 tetramer interface [polypeptide binding]; other site 266117008463 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 266117008464 TPR repeat; Region: TPR_11; pfam13414 266117008465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117008466 TPR motif; other site 266117008467 TPR repeat; Region: TPR_11; pfam13414 266117008468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117008469 TPR motif; other site 266117008470 binding surface 266117008471 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266117008472 iron-sulfur cluster [ion binding]; other site 266117008473 [2Fe-2S] cluster binding site [ion binding]; other site 266117008474 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266117008475 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 266117008476 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 266117008477 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 266117008478 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266117008479 active site 266117008480 dimer interface [polypeptide binding]; other site 266117008481 effector binding site; other site 266117008482 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266117008483 TSCPD domain; Region: TSCPD; pfam12637 266117008484 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266117008485 ATP cone domain; Region: ATP-cone; pfam03477 266117008486 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266117008487 nucleoside/Zn binding site; other site 266117008488 dimer interface [polypeptide binding]; other site 266117008489 catalytic motif [active] 266117008490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266117008491 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266117008492 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266117008493 active site 266117008494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117008495 dimerization interface [polypeptide binding]; other site 266117008496 putative DNA binding site [nucleotide binding]; other site 266117008497 putative Zn2+ binding site [ion binding]; other site 266117008498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266117008499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266117008500 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 266117008501 argininosuccinate synthase; Provisional; Region: PRK13820 266117008502 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 266117008503 ANP binding site [chemical binding]; other site 266117008504 Substrate Binding Site II [chemical binding]; other site 266117008505 Substrate Binding Site I [chemical binding]; other site 266117008506 Uncharacterized conserved protein [Function unknown]; Region: COG3603 266117008507 Family description; Region: ACT_7; pfam13840 266117008508 Arginine repressor [Transcription]; Region: ArgR; COG1438 266117008509 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 266117008510 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 266117008511 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 266117008512 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266117008513 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266117008514 heterotetramer interface [polypeptide binding]; other site 266117008515 active site pocket [active] 266117008516 cleavage site 266117008517 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 266117008518 N-acetyl-L-glutamate binding site [chemical binding]; other site 266117008519 acetylornithine aminotransferase; Provisional; Region: PRK02627 266117008520 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117008521 inhibitor-cofactor binding pocket; inhibition site 266117008522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117008523 catalytic residue [active] 266117008524 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266117008525 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266117008526 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266117008527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266117008528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266117008529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117008530 catalytic residue [active] 266117008531 AMP-binding enzyme; Region: AMP-binding; pfam00501 266117008532 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 266117008533 acyl-activating enzyme (AAE) consensus motif; other site 266117008534 putative AMP binding site [chemical binding]; other site 266117008535 putative active site [active] 266117008536 putative CoA binding site [chemical binding]; other site 266117008537 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 266117008538 active site 266117008539 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266117008540 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 266117008541 substrate binding site [chemical binding]; other site 266117008542 oxyanion hole (OAH) forming residues; other site 266117008543 trimer interface [polypeptide binding]; other site 266117008544 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 266117008545 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 266117008546 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 266117008547 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 266117008548 dimer interface [polypeptide binding]; other site 266117008549 tetramer interface [polypeptide binding]; other site 266117008550 PYR/PP interface [polypeptide binding]; other site 266117008551 TPP binding site [chemical binding]; other site 266117008552 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 266117008553 TPP-binding site; other site 266117008554 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266117008555 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266117008556 N- and C-terminal domain interface [polypeptide binding]; other site 266117008557 D-xylulose kinase; Region: XylB; TIGR01312 266117008558 active site 266117008559 MgATP binding site [chemical binding]; other site 266117008560 catalytic site [active] 266117008561 metal binding site [ion binding]; metal-binding site 266117008562 xylulose binding site [chemical binding]; other site 266117008563 homodimer interface [polypeptide binding]; other site 266117008564 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117008565 active site 266117008566 catalytic site [active] 266117008567 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 266117008568 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 266117008569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117008570 inhibitor-cofactor binding pocket; inhibition site 266117008571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117008572 catalytic residue [active] 266117008573 succinic semialdehyde dehydrogenase; Region: PLN02278 266117008574 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266117008575 tetramerization interface [polypeptide binding]; other site 266117008576 NAD(P) binding site [chemical binding]; other site 266117008577 catalytic residues [active] 266117008578 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 266117008579 Na binding site [ion binding]; other site 266117008580 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266117008581 agmatinase; Region: agmatinase; TIGR01230 266117008582 oligomer interface [polypeptide binding]; other site 266117008583 putative active site [active] 266117008584 Mn binding site [ion binding]; other site 266117008585 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266117008586 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266117008587 hexamer interface [polypeptide binding]; other site 266117008588 ligand binding site [chemical binding]; other site 266117008589 putative active site [active] 266117008590 NAD(P) binding site [chemical binding]; other site 266117008591 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266117008592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266117008593 DNA binding residues [nucleotide binding] 266117008594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266117008595 sequence-specific DNA binding site [nucleotide binding]; other site 266117008596 salt bridge; other site 266117008597 Cupin domain; Region: Cupin_2; pfam07883 266117008598 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266117008599 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266117008600 hypothetical protein; Provisional; Region: PRK06541 266117008601 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266117008602 inhibitor-cofactor binding pocket; inhibition site 266117008603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117008604 catalytic residue [active] 266117008605 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266117008606 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266117008607 Walker A/P-loop; other site 266117008608 ATP binding site [chemical binding]; other site 266117008609 Q-loop/lid; other site 266117008610 ABC transporter signature motif; other site 266117008611 Walker B; other site 266117008612 D-loop; other site 266117008613 H-loop/switch region; other site 266117008614 TOBE domain; Region: TOBE_2; pfam08402 266117008615 TOBE domain; Region: TOBE_2; pfam08402 266117008616 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266117008617 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 266117008618 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266117008619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008620 dimer interface [polypeptide binding]; other site 266117008621 conserved gate region; other site 266117008622 putative PBP binding loops; other site 266117008623 ABC-ATPase subunit interface; other site 266117008624 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266117008625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008626 dimer interface [polypeptide binding]; other site 266117008627 conserved gate region; other site 266117008628 putative PBP binding loops; other site 266117008629 ABC-ATPase subunit interface; other site 266117008630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117008631 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 266117008632 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 266117008633 tetrameric interface [polypeptide binding]; other site 266117008634 NAD binding site [chemical binding]; other site 266117008635 catalytic residues [active] 266117008636 substrate binding site [chemical binding]; other site 266117008637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117008638 PAS domain; Region: PAS_9; pfam13426 266117008639 putative active site [active] 266117008640 heme pocket [chemical binding]; other site 266117008641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266117008642 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266117008643 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266117008644 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266117008645 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266117008646 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266117008647 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 266117008648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266117008649 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266117008650 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 266117008651 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 266117008652 Glutamate binding site [chemical binding]; other site 266117008653 homodimer interface [polypeptide binding]; other site 266117008654 NAD binding site [chemical binding]; other site 266117008655 catalytic residues [active] 266117008656 Proline dehydrogenase; Region: Pro_dh; cl03282 266117008657 amino acid transporter; Region: 2A0306; TIGR00909 266117008658 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 266117008659 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 266117008660 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117008661 NAD binding site [chemical binding]; other site 266117008662 catalytic residues [active] 266117008663 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266117008664 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 266117008665 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266117008666 ornithine cyclodeaminase; Validated; Region: PRK07340 266117008667 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266117008668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117008669 dimerization interface [polypeptide binding]; other site 266117008670 putative DNA binding site [nucleotide binding]; other site 266117008671 putative Zn2+ binding site [ion binding]; other site 266117008672 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266117008673 active site 266117008674 catalytic residues [active] 266117008675 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 266117008676 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 266117008677 putative active site; other site 266117008678 putative metal binding residues [ion binding]; other site 266117008679 signature motif; other site 266117008680 putative triphosphate binding site [ion binding]; other site 266117008681 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 266117008682 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 266117008683 MgtC family; Region: MgtC; pfam02308 266117008684 polyphosphate kinase; Provisional; Region: PRK05443 266117008685 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266117008686 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266117008687 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 266117008688 putative domain interface [polypeptide binding]; other site 266117008689 putative active site [active] 266117008690 catalytic site [active] 266117008691 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266117008692 putative domain interface [polypeptide binding]; other site 266117008693 putative active site [active] 266117008694 catalytic site [active] 266117008695 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 266117008696 dimer interface [polypeptide binding]; other site 266117008697 [2Fe-2S] cluster binding site [ion binding]; other site 266117008698 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 266117008699 active site 266117008700 catalytic site [active] 266117008701 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266117008702 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266117008703 ligand binding site [chemical binding]; other site 266117008704 homodimer interface [polypeptide binding]; other site 266117008705 NAD(P) binding site [chemical binding]; other site 266117008706 trimer interface B [polypeptide binding]; other site 266117008707 trimer interface A [polypeptide binding]; other site 266117008708 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266117008709 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266117008710 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266117008711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117008712 dimerization interface [polypeptide binding]; other site 266117008713 putative DNA binding site [nucleotide binding]; other site 266117008714 putative Zn2+ binding site [ion binding]; other site 266117008715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266117008716 active site residue [active] 266117008717 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266117008718 active site residue [active] 266117008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117008721 putative substrate translocation pore; other site 266117008722 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 266117008723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266117008724 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266117008725 Predicted ATPase [General function prediction only]; Region: COG3903 266117008726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266117008727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117008728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117008729 DNA binding residues [nucleotide binding] 266117008730 dimerization interface [polypeptide binding]; other site 266117008731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117008732 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 266117008733 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 266117008734 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 266117008735 Fe-S cluster binding site [ion binding]; other site 266117008736 DNA binding site [nucleotide binding] 266117008737 active site 266117008738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 266117008739 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 266117008740 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266117008741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266117008742 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266117008743 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266117008744 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 266117008745 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266117008746 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266117008747 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266117008748 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266117008749 Qi binding site; other site 266117008750 intrachain domain interface; other site 266117008751 interchain domain interface [polypeptide binding]; other site 266117008752 heme bH binding site [chemical binding]; other site 266117008753 heme bL binding site [chemical binding]; other site 266117008754 Qo binding site; other site 266117008755 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266117008756 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266117008757 iron-sulfur cluster [ion binding]; other site 266117008758 [2Fe-2S] cluster binding site [ion binding]; other site 266117008759 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266117008760 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 266117008761 Asp23 family; Region: Asp23; pfam03780 266117008762 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 266117008763 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 266117008764 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 266117008765 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266117008766 active site 266117008767 homotetramer interface [polypeptide binding]; other site 266117008768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117008769 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 266117008770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266117008771 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266117008772 ATP binding site [chemical binding]; other site 266117008773 Mg2+ binding site [ion binding]; other site 266117008774 G-X-G motif; other site 266117008775 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266117008776 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266117008777 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266117008778 NlpC/P60 family; Region: NLPC_P60; pfam00877 266117008779 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266117008780 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266117008781 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266117008782 Peptidase family M23; Region: Peptidase_M23; pfam01551 266117008783 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 266117008784 Peptidase family M50; Region: Peptidase_M50; pfam02163 266117008785 active site 266117008786 putative substrate binding region [chemical binding]; other site 266117008787 HAMP domain; Region: HAMP; pfam00672 266117008788 dimerization interface [polypeptide binding]; other site 266117008789 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266117008790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117008791 dimer interface [polypeptide binding]; other site 266117008792 phosphorylation site [posttranslational modification] 266117008793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117008794 ATP binding site [chemical binding]; other site 266117008795 Mg2+ binding site [ion binding]; other site 266117008796 G-X-G motif; other site 266117008797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117008798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117008799 active site 266117008800 phosphorylation site [posttranslational modification] 266117008801 intermolecular recognition site; other site 266117008802 dimerization interface [polypeptide binding]; other site 266117008803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117008804 DNA binding site [nucleotide binding] 266117008805 hypothetical protein; Validated; Region: PRK07883 266117008806 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266117008807 active site 266117008808 catalytic site [active] 266117008809 substrate binding site [chemical binding]; other site 266117008810 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266117008811 GIY-YIG motif/motif A; other site 266117008812 active site 266117008813 catalytic site [active] 266117008814 putative DNA binding site [nucleotide binding]; other site 266117008815 metal binding site [ion binding]; metal-binding site 266117008816 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266117008817 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266117008818 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266117008819 dimer interface [polypeptide binding]; other site 266117008820 putative functional site; other site 266117008821 putative MPT binding site; other site 266117008822 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 266117008823 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 266117008824 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266117008825 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266117008826 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266117008827 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266117008828 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 266117008829 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266117008830 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266117008831 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266117008832 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266117008833 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266117008834 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266117008835 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266117008836 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266117008837 Cysteine-rich domain; Region: CCG; pfam02754 266117008838 Cysteine-rich domain; Region: CCG; pfam02754 266117008839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117008840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117008841 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266117008842 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266117008843 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 266117008844 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 266117008845 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266117008846 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266117008847 active site 266117008848 substrate binding site [chemical binding]; other site 266117008849 FMN binding site [chemical binding]; other site 266117008850 putative catalytic residues [active] 266117008851 short chain dehydrogenase; Provisional; Region: PRK07326 266117008852 classical (c) SDRs; Region: SDR_c; cd05233 266117008853 NAD(P) binding site [chemical binding]; other site 266117008854 active site 266117008855 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266117008856 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266117008857 putative ligand binding site [chemical binding]; other site 266117008858 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266117008859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266117008860 TM-ABC transporter signature motif; other site 266117008861 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266117008862 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266117008863 Walker A/P-loop; other site 266117008864 ATP binding site [chemical binding]; other site 266117008865 Q-loop/lid; other site 266117008866 ABC transporter signature motif; other site 266117008867 Walker B; other site 266117008868 D-loop; other site 266117008869 H-loop/switch region; other site 266117008870 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266117008871 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266117008872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117008873 DNA-binding site [nucleotide binding]; DNA binding site 266117008874 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266117008875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266117008876 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266117008877 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117008878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117008879 active site 266117008880 catalytic tetrad [active] 266117008881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266117008882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117008883 NAD(P) binding site [chemical binding]; other site 266117008884 active site 266117008885 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266117008886 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117008887 active site pocket [active] 266117008888 short chain dehydrogenase; Provisional; Region: PRK07326 266117008889 classical (c) SDRs; Region: SDR_c; cd05233 266117008890 NAD(P) binding site [chemical binding]; other site 266117008891 active site 266117008892 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 266117008893 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117008894 putative NAD(P) binding site [chemical binding]; other site 266117008895 catalytic Zn binding site [ion binding]; other site 266117008896 short chain dehydrogenase; Provisional; Region: PRK06138 266117008897 classical (c) SDRs; Region: SDR_c; cd05233 266117008898 NAD(P) binding site [chemical binding]; other site 266117008899 active site 266117008900 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 266117008901 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117008902 putative active site pocket [active] 266117008903 metal binding site [ion binding]; metal-binding site 266117008904 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 266117008905 putative NAD(P) binding site [chemical binding]; other site 266117008906 active site 266117008907 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266117008908 catalytic triad [active] 266117008909 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266117008910 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 266117008911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266117008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266117008913 active site 266117008914 phosphorylation site [posttranslational modification] 266117008915 intermolecular recognition site; other site 266117008916 dimerization interface [polypeptide binding]; other site 266117008917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266117008918 DNA binding site [nucleotide binding] 266117008919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266117008920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266117008921 dimerization interface [polypeptide binding]; other site 266117008922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266117008923 dimer interface [polypeptide binding]; other site 266117008924 phosphorylation site [posttranslational modification] 266117008925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117008926 ATP binding site [chemical binding]; other site 266117008927 Mg2+ binding site [ion binding]; other site 266117008928 G-X-G motif; other site 266117008929 Predicted membrane protein [Function unknown]; Region: COG3212 266117008930 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266117008931 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266117008932 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266117008933 protein binding site [polypeptide binding]; other site 266117008934 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266117008935 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 266117008936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117008937 catalytic residue [active] 266117008938 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266117008939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117008940 Walker A/P-loop; other site 266117008941 ATP binding site [chemical binding]; other site 266117008942 Q-loop/lid; other site 266117008943 ABC transporter signature motif; other site 266117008944 Walker B; other site 266117008945 D-loop; other site 266117008946 H-loop/switch region; other site 266117008947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266117008948 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266117008949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266117008950 Walker A/P-loop; other site 266117008951 ATP binding site [chemical binding]; other site 266117008952 Q-loop/lid; other site 266117008953 ABC transporter signature motif; other site 266117008954 Walker B; other site 266117008955 D-loop; other site 266117008956 H-loop/switch region; other site 266117008957 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266117008958 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266117008959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008960 dimer interface [polypeptide binding]; other site 266117008961 conserved gate region; other site 266117008962 putative PBP binding loops; other site 266117008963 ABC-ATPase subunit interface; other site 266117008964 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266117008965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008966 putative PBP binding loops; other site 266117008967 dimer interface [polypeptide binding]; other site 266117008968 ABC-ATPase subunit interface; other site 266117008969 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266117008970 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266117008971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266117008972 putative substrate translocation pore; other site 266117008973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266117008974 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266117008975 NMT1/THI5 like; Region: NMT1; pfam09084 266117008976 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266117008977 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266117008978 active site 266117008979 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266117008980 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266117008981 Walker A/P-loop; other site 266117008982 ATP binding site [chemical binding]; other site 266117008983 Q-loop/lid; other site 266117008984 ABC transporter signature motif; other site 266117008985 Walker B; other site 266117008986 D-loop; other site 266117008987 H-loop/switch region; other site 266117008988 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266117008989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008990 putative PBP binding loops; other site 266117008991 dimer interface [polypeptide binding]; other site 266117008992 ABC-ATPase subunit interface; other site 266117008993 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266117008994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266117008995 dimer interface [polypeptide binding]; other site 266117008996 conserved gate region; other site 266117008997 putative PBP binding loops; other site 266117008998 ABC-ATPase subunit interface; other site 266117008999 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 266117009000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117009001 active site 266117009002 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266117009003 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266117009004 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266117009005 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117009006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117009007 DNA-binding site [nucleotide binding]; DNA binding site 266117009008 FCD domain; Region: FCD; pfam07729 266117009009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266117009010 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266117009011 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266117009012 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain; Region: MR_MLE_N; pfam02746 266117009013 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 266117009014 active site 266117009015 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266117009016 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 266117009017 active site 266117009018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117009019 classical (c) SDRs; Region: SDR_c; cd05233 266117009020 NAD(P) binding site [chemical binding]; other site 266117009021 active site 266117009022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266117009023 classical (c) SDRs; Region: SDR_c; cd05233 266117009024 NAD(P) binding site [chemical binding]; other site 266117009025 active site 266117009026 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266117009027 E3 interaction surface; other site 266117009028 lipoyl attachment site [posttranslational modification]; other site 266117009029 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266117009030 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266117009031 alpha subunit interface [polypeptide binding]; other site 266117009032 TPP binding site [chemical binding]; other site 266117009033 heterodimer interface [polypeptide binding]; other site 266117009034 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266117009035 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266117009036 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266117009037 tetramer interface [polypeptide binding]; other site 266117009038 TPP-binding site [chemical binding]; other site 266117009039 heterodimer interface [polypeptide binding]; other site 266117009040 phosphorylation loop region [posttranslational modification] 266117009041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266117009042 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266117009043 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266117009044 Na binding site [ion binding]; other site 266117009045 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266117009046 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 266117009047 AIR carboxylase; Region: AIRC; smart01001 266117009048 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266117009049 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266117009050 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266117009051 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266117009052 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266117009053 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 266117009054 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 266117009055 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117009056 FAD binding domain; Region: FAD_binding_4; pfam01565 266117009057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009058 Ligand Binding Site [chemical binding]; other site 266117009059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009060 Ligand Binding Site [chemical binding]; other site 266117009061 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 266117009062 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266117009063 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266117009064 oligomer interface [polypeptide binding]; other site 266117009065 metal binding site [ion binding]; metal-binding site 266117009066 metal binding site [ion binding]; metal-binding site 266117009067 putative Cl binding site [ion binding]; other site 266117009068 basic sphincter; other site 266117009069 hydrophobic gate; other site 266117009070 periplasmic entrance; other site 266117009071 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117009072 FAD binding domain; Region: FAD_binding_4; pfam01565 266117009073 Homeodomain-like domain; Region: HTH_23; pfam13384 266117009074 Winged helix-turn helix; Region: HTH_29; pfam13551 266117009075 Homeodomain-like domain; Region: HTH_32; pfam13565 266117009076 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266117009077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009078 Ligand Binding Site [chemical binding]; other site 266117009079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009080 Ligand Binding Site [chemical binding]; other site 266117009081 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009082 Ligand Binding Site [chemical binding]; other site 266117009083 phosphoenolpyruvate synthase; Validated; Region: PRK06464 266117009084 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266117009085 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266117009086 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266117009087 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266117009088 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266117009089 putative dimer interface [polypeptide binding]; other site 266117009090 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 266117009091 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266117009092 catalytic Zn binding site [ion binding]; other site 266117009093 structural Zn binding site [ion binding]; other site 266117009094 NAD(P) binding site [chemical binding]; other site 266117009095 sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116 266117009096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266117009097 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266117009098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266117009099 motif II; other site 266117009100 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266117009101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266117009102 sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116 266117009103 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266117009104 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266117009105 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266117009106 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266117009107 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 266117009108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117009109 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 266117009110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009111 Ligand Binding Site [chemical binding]; other site 266117009112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009113 Ligand Binding Site [chemical binding]; other site 266117009114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266117009115 PAS domain; Region: PAS_9; pfam13426 266117009116 putative active site [active] 266117009117 heme pocket [chemical binding]; other site 266117009118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117009119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117009120 DNA binding residues [nucleotide binding] 266117009121 dimerization interface [polypeptide binding]; other site 266117009122 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266117009123 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117009124 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266117009125 FAD binding domain; Region: FAD_binding_4; pfam01565 266117009126 Berberine and berberine like; Region: BBE; pfam08031 266117009127 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266117009128 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 266117009129 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117009130 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266117009131 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266117009132 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266117009133 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266117009134 CoA binding domain; Region: CoA_binding; cl17356 266117009135 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266117009136 NAD(P) binding site [chemical binding]; other site 266117009137 homodimer interface [polypeptide binding]; other site 266117009138 substrate binding site [chemical binding]; other site 266117009139 active site 266117009140 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 266117009141 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 266117009142 putative catalytic motif [active] 266117009143 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117009144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266117009145 NAD(P) binding site [chemical binding]; other site 266117009146 active site 266117009147 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266117009148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266117009149 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266117009150 active site 266117009151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117009152 active site 266117009153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266117009154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117009155 active site 266117009156 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 266117009157 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117009158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266117009159 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117009160 sulfotransferase; Region: PLN02164 266117009161 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117009162 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266117009163 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266117009164 NADP binding site [chemical binding]; other site 266117009165 active site 266117009166 putative substrate binding site [chemical binding]; other site 266117009167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266117009168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266117009169 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 266117009170 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117009171 sulfotransferase; Region: PLN02164 266117009172 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266117009173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117009174 active site 266117009175 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266117009176 Sulfatase; Region: Sulfatase; pfam00884 266117009177 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266117009178 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266117009179 amidase catalytic site [active] 266117009180 Zn binding residues [ion binding]; other site 266117009181 substrate binding site [chemical binding]; other site 266117009182 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 266117009183 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117009184 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 266117009185 NAD binding site [chemical binding]; other site 266117009186 substrate binding site [chemical binding]; other site 266117009187 homodimer interface [polypeptide binding]; other site 266117009188 active site 266117009189 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 266117009190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266117009191 NAD binding site [chemical binding]; other site 266117009192 putative substrate binding site 2 [chemical binding]; other site 266117009193 putative substrate binding site 1 [chemical binding]; other site 266117009194 active site 266117009195 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266117009196 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266117009197 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266117009198 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 266117009199 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266117009200 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266117009201 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266117009202 Walker A/P-loop; other site 266117009203 ATP binding site [chemical binding]; other site 266117009204 Q-loop/lid; other site 266117009205 ABC transporter signature motif; other site 266117009206 Walker B; other site 266117009207 D-loop; other site 266117009208 H-loop/switch region; other site 266117009209 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 266117009210 putative carbohydrate binding site [chemical binding]; other site 266117009211 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266117009212 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266117009213 Probable Catalytic site; other site 266117009214 metal-binding site 266117009215 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266117009216 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266117009217 Probable Catalytic site; other site 266117009218 metal-binding site 266117009219 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 266117009220 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266117009221 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266117009222 substrate binding site; other site 266117009223 tetramer interface; other site 266117009224 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266117009225 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266117009226 NAD binding site [chemical binding]; other site 266117009227 substrate binding site [chemical binding]; other site 266117009228 homodimer interface [polypeptide binding]; other site 266117009229 active site 266117009230 threonine synthase; Reviewed; Region: PRK06721 266117009231 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 266117009232 homodimer interface [polypeptide binding]; other site 266117009233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117009234 catalytic residue [active] 266117009235 homoserine kinase; Provisional; Region: PRK01212 266117009236 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266117009237 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266117009238 PYR/PP interface [polypeptide binding]; other site 266117009239 dimer interface [polypeptide binding]; other site 266117009240 TPP binding site [chemical binding]; other site 266117009241 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266117009242 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266117009243 TPP-binding site [chemical binding]; other site 266117009244 dimer interface [polypeptide binding]; other site 266117009245 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266117009246 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266117009247 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266117009248 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266117009249 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266117009250 homodimer interface [polypeptide binding]; other site 266117009251 substrate-cofactor binding pocket; other site 266117009252 catalytic residue [active] 266117009253 2-isopropylmalate synthase; Validated; Region: PRK00915 266117009254 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 266117009255 active site 266117009256 catalytic residues [active] 266117009257 metal binding site [ion binding]; metal-binding site 266117009258 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266117009259 tartrate dehydrogenase; Region: TTC; TIGR02089 266117009260 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 266117009261 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 266117009262 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 266117009263 active site 266117009264 catalytic residues [active] 266117009265 metal binding site [ion binding]; metal-binding site 266117009266 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266117009267 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266117009268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117009269 DNA-binding site [nucleotide binding]; DNA binding site 266117009270 FCD domain; Region: FCD; pfam07729 266117009271 tricarballylate dehydrogenase; Validated; Region: PRK08274 266117009272 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266117009273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266117009274 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266117009275 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266117009276 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266117009277 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 266117009278 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266117009279 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009280 Ligand Binding Site [chemical binding]; other site 266117009281 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266117009282 Ligand Binding Site [chemical binding]; other site 266117009283 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 266117009284 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 266117009285 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 266117009286 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117009287 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 266117009288 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 266117009289 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266117009290 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 266117009291 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266117009292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266117009293 active site 266117009294 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266117009295 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 266117009296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266117009297 phosphate binding site [ion binding]; other site 266117009298 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266117009299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266117009300 Walker A motif; other site 266117009301 ATP binding site [chemical binding]; other site 266117009302 Walker B motif; other site 266117009303 arginine finger; other site 266117009304 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 266117009305 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 266117009306 NAD binding site [chemical binding]; other site 266117009307 catalytic Zn binding site [ion binding]; other site 266117009308 substrate binding site [chemical binding]; other site 266117009309 structural Zn binding site [ion binding]; other site 266117009310 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 266117009311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266117009312 FeS/SAM binding site; other site 266117009313 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 266117009314 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 266117009315 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 266117009316 classical (c) SDRs; Region: SDR_c; cd05233 266117009317 NAD(P) binding site [chemical binding]; other site 266117009318 active site 266117009319 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266117009320 DNA methylase; Region: N6_N4_Mtase; pfam01555 266117009321 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266117009322 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 266117009323 Na binding site [ion binding]; other site 266117009324 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266117009325 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266117009326 active site 266117009327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117009328 binding surface 266117009329 TPR motif; other site 266117009330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117009331 binding surface 266117009332 TPR motif; other site 266117009333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266117009334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117009335 binding surface 266117009336 TPR motif; other site 266117009337 TPR repeat; Region: TPR_11; pfam13414 266117009338 TPR repeat; Region: TPR_11; pfam13414 266117009339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117009340 binding surface 266117009341 TPR motif; other site 266117009342 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 266117009343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 266117009344 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266117009345 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266117009346 intersubunit interface [polypeptide binding]; other site 266117009347 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 266117009348 Peptidase family M50; Region: Peptidase_M50; pfam02163 266117009349 active site 266117009350 putative substrate binding region [chemical binding]; other site 266117009351 FOG: CBS domain [General function prediction only]; Region: COG0517 266117009352 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 266117009353 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 266117009354 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266117009355 catalytic site [active] 266117009356 putative active site [active] 266117009357 putative substrate binding site [chemical binding]; other site 266117009358 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 266117009359 active site 266117009360 DNA binding site [nucleotide binding] 266117009361 catalytic site [active] 266117009362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266117009363 Coenzyme A binding pocket [chemical binding]; other site 266117009364 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266117009365 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 266117009366 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 266117009367 active site 266117009368 catalytic site [active] 266117009369 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266117009370 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117009371 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 266117009372 NAD(P) binding site [chemical binding]; other site 266117009373 catalytic residues [active] 266117009374 epoxyqueuosine reductase; Region: TIGR00276 266117009375 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266117009376 HEAT repeats; Region: HEAT_2; pfam13646 266117009377 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266117009378 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266117009379 HSP70 interaction site [polypeptide binding]; other site 266117009380 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 266117009381 active site 266117009382 Zn binding site [ion binding]; other site 266117009383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266117009384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266117009385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266117009386 active site 266117009387 catalytic tetrad [active] 266117009388 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 266117009389 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 266117009390 CoA binding domain; Region: CoA_binding; pfam02629 266117009391 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266117009392 lipoyl attachment site [posttranslational modification]; other site 266117009393 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266117009394 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266117009395 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266117009396 tetramer interface [polypeptide binding]; other site 266117009397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117009398 catalytic residue [active] 266117009399 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 266117009400 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 266117009401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266117009402 catalytic residue [active] 266117009403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266117009404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266117009405 DNA binding residues [nucleotide binding] 266117009406 dimerization interface [polypeptide binding]; other site 266117009407 Cupin domain; Region: Cupin_2; pfam07883 266117009408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266117009409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266117009410 Cupin domain; Region: Cupin_2; pfam07883 266117009411 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266117009412 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266117009413 dimer interface [polypeptide binding]; other site 266117009414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266117009415 catalytic residue [active] 266117009416 short chain dehydrogenase; Provisional; Region: PRK06057 266117009417 classical (c) SDRs; Region: SDR_c; cd05233 266117009418 NAD(P) binding site [chemical binding]; other site 266117009419 active site 266117009420 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266117009421 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266117009422 NAD(P) binding site [chemical binding]; other site 266117009423 catalytic residues [active] 266117009424 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266117009425 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266117009426 catalytic triad [active] 266117009427 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266117009428 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266117009429 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266117009430 ethanolamine permease; Region: 2A0305; TIGR00908 266117009431 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266117009432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266117009433 DNA-binding site [nucleotide binding]; DNA binding site 266117009434 UTRA domain; Region: UTRA; pfam07702 266117009435 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 266117009436 dimer interface [polypeptide binding]; other site 266117009437 putative tRNA-binding site [nucleotide binding]; other site 266117009438 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 266117009439 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266117009440 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 266117009441 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266117009442 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266117009443 HIGH motif; other site 266117009444 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266117009445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266117009446 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266117009447 active site 266117009448 KMSKS motif; other site 266117009449 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266117009450 tRNA binding surface [nucleotide binding]; other site 266117009451 Integral membrane protein DUF92; Region: DUF92; pfam01940 266117009452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266117009453 TPR motif; other site 266117009454 TPR repeat; Region: TPR_11; pfam13414 266117009455 binding surface 266117009456 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266117009457 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266117009458 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266117009459 catalytic residue [active] 266117009460 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266117009461 ParB-like nuclease domain; Region: ParB; smart00470 266117009462 KorB domain; Region: KorB; pfam08535 266117009463 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266117009464 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266117009465 P-loop; other site 266117009466 Magnesium ion binding site [ion binding]; other site 266117009467 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 266117009468 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 266117009469 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 266117009470 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 266117009471 G-X-X-G motif; other site 266117009472 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 266117009473 RxxxH motif; other site 266117009474 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 266117009475 Haemolytic domain; Region: Haemolytic; pfam01809 266117009476 Ribonuclease P; Region: Ribonuclease_P; pfam00825 266117009477 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 266117009478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266117009479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266117009480 ATP binding site [chemical binding]; other site 266117009481 Mg2+ binding site [ion binding]; other site 266117009482 G-X-G motif; other site 266117009483 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266117009484 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266117009485 putative DNA binding site [nucleotide binding]; other site 266117009486 putative Zn2+ binding site [ion binding]; other site