-- dump date   	20140620_042044
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
213810000001	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
213810000002	metal binding site [ion binding]; metal-binding site
213810000003	active site
213810000004	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810000005	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
213810000006	putative sugar binding sites [chemical binding]; other site
213810000007	Q-X-W motif; other site
213810000008	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
213810000009	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810000010	ligand binding site [chemical binding]; other site
213810000011	dimerization interface [polypeptide binding]; other site
213810000012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810000013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810000014	metal binding site [ion binding]; metal-binding site
213810000015	active site
213810000016	I-site; other site
213810000017	Helix-turn-helix domain; Region: HTH_18; pfam12833
213810000018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810000019	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
213810000020	putative metal binding residues [ion binding]; other site
213810000021	signature motif; other site
213810000022	dimer interface [polypeptide binding]; other site
213810000023	active site
213810000024	polyP binding site; other site
213810000025	substrate binding site [chemical binding]; other site
213810000026	acceptor-phosphate pocket; other site
213810000027	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
213810000028	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
213810000029	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
213810000030	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
213810000031	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
213810000032	putative catalytic cysteine [active]
213810000033	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
213810000034	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
213810000035	putative ligand binding site [chemical binding]; other site
213810000036	putative NAD binding site [chemical binding]; other site
213810000037	catalytic site [active]
213810000038	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
213810000039	DNA gyrase B; Region: DNA_gyraseB; pfam00204
213810000040	ATP binding site [chemical binding]; other site
213810000041	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
213810000042	active site
213810000043	putative metal-binding site [ion binding]; other site
213810000044	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
213810000045	Clostripain family; Region: Peptidase_C11; pfam03415
213810000046	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
213810000047	active site
213810000048	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
213810000049	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
213810000050	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
213810000051	dimer interface [polypeptide binding]; other site
213810000052	active site
213810000053	glycine-pyridoxal phosphate binding site [chemical binding]; other site
213810000054	folate binding site [chemical binding]; other site
213810000055	recombination factor protein RarA; Reviewed; Region: PRK13342
213810000056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810000057	Walker A motif; other site
213810000058	ATP binding site [chemical binding]; other site
213810000059	Walker B motif; other site
213810000060	arginine finger; other site
213810000061	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
213810000062	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
213810000063	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
213810000064	RNA binding site [nucleotide binding]; other site
213810000065	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
213810000066	RNA binding site [nucleotide binding]; other site
213810000067	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
213810000068	peptide chain release factor 1; Validated; Region: prfA; PRK00591
213810000069	This domain is found in peptide chain release factors; Region: PCRF; smart00937
213810000070	RF-1 domain; Region: RF-1; pfam00472
213810000071	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
213810000072	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
213810000073	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
213810000074	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
213810000075	oligomer interface [polypeptide binding]; other site
213810000076	putative active site [active]
213810000077	metal binding site [ion binding]; metal-binding site
213810000078	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
213810000079	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
213810000080	sporulation sigma factor SigE; Reviewed; Region: PRK08301
213810000081	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810000082	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810000083	DNA binding residues [nucleotide binding]
213810000084	Type III pantothenate kinase; Region: Pan_kinase; cl17198
213810000085	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
213810000086	Predicted membrane protein [Function unknown]; Region: COG4684
213810000087	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
213810000088	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
213810000089	Walker A/P-loop; other site
213810000090	ATP binding site [chemical binding]; other site
213810000091	Q-loop/lid; other site
213810000092	ABC transporter signature motif; other site
213810000093	Walker B; other site
213810000094	D-loop; other site
213810000095	H-loop/switch region; other site
213810000096	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
213810000097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810000098	dimer interface [polypeptide binding]; other site
213810000099	conserved gate region; other site
213810000100	putative PBP binding loops; other site
213810000101	ABC-ATPase subunit interface; other site
213810000102	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
213810000103	NMT1/THI5 like; Region: NMT1; pfam09084
213810000104	NMT1/THI5 like; Region: NMT1; pfam09084
213810000105	phenylhydantoinase; Validated; Region: PRK08323
213810000106	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
213810000107	tetramer interface [polypeptide binding]; other site
213810000108	active site
213810000109	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
213810000110	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
213810000111	phosphate binding site [ion binding]; other site
213810000112	4Fe-4S binding domain; Region: Fer4; pfam00037
213810000113	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
213810000114	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
213810000115	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
213810000116	hypothetical protein; Provisional; Region: PRK06062
213810000117	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
213810000118	inhibitor-cofactor binding pocket; inhibition site
213810000119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810000120	catalytic residue [active]
213810000121	allantoate amidohydrolase; Reviewed; Region: PRK09290
213810000122	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
213810000123	active site
213810000124	metal binding site [ion binding]; metal-binding site
213810000125	dimer interface [polypeptide binding]; other site
213810000126	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
213810000127	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
213810000128	active site
213810000129	NAD binding site [chemical binding]; other site
213810000130	metal binding site [ion binding]; metal-binding site
213810000131	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
213810000132	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
213810000133	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
213810000134	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810000135	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
213810000136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810000137	DNA binding residues [nucleotide binding]
213810000138	DNA primase; Validated; Region: dnaG; PRK05667
213810000139	CHC2 zinc finger; Region: zf-CHC2; cl17510
213810000140	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
213810000141	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
213810000142	active site
213810000143	metal binding site [ion binding]; metal-binding site
213810000144	interdomain interaction site; other site
213810000145	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
213810000146	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
213810000147	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
213810000148	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810000149	Zn2+ binding site [ion binding]; other site
213810000150	Mg2+ binding site [ion binding]; other site
213810000151	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
213810000152	Uncharacterized conserved protein [Function unknown]; Region: COG1739
213810000153	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
213810000154	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
213810000155	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
213810000156	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
213810000157	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
213810000158	active site
213810000159	substrate binding site [chemical binding]; other site
213810000160	metal binding site [ion binding]; metal-binding site
213810000161	hybrid cluster protein; Provisional; Region: PRK05290
213810000162	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810000163	ACS interaction site; other site
213810000164	CODH interaction site; other site
213810000165	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810000166	ACS interaction site; other site
213810000167	CODH interaction site; other site
213810000168	metal cluster binding site [ion binding]; other site
213810000169	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810000170	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810000171	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810000172	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810000173	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810000174	putative lipid kinase; Reviewed; Region: PRK13337
213810000175	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
213810000176	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
213810000177	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
213810000178	Thioesterase domain; Region: Thioesterase; pfam00975
213810000179	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
213810000180	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
213810000181	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
213810000182	active site
213810000183	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
213810000184	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
213810000185	NAD(P) binding site [chemical binding]; other site
213810000186	active site
213810000187	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
213810000188	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
213810000189	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810000190	acyl-activating enzyme (AAE) consensus motif; other site
213810000191	AMP binding site [chemical binding]; other site
213810000192	active site
213810000193	CoA binding site [chemical binding]; other site
213810000194	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
213810000195	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810000196	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810000197	Walker A/P-loop; other site
213810000198	ATP binding site [chemical binding]; other site
213810000199	Q-loop/lid; other site
213810000200	ABC transporter signature motif; other site
213810000201	Walker B; other site
213810000202	D-loop; other site
213810000203	H-loop/switch region; other site
213810000204	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
213810000205	FtsX-like permease family; Region: FtsX; pfam02687
213810000206	FtsX-like permease family; Region: FtsX; pfam02687
213810000207	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
213810000208	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
213810000209	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
213810000210	NAD(P) binding site [chemical binding]; other site
213810000211	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
213810000212	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
213810000213	dimer interface [polypeptide binding]; other site
213810000214	active site
213810000215	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
213810000216	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
213810000217	acyl-activating enzyme (AAE) consensus motif; other site
213810000218	putative AMP binding site [chemical binding]; other site
213810000219	putative active site [active]
213810000220	putative CoA binding site [chemical binding]; other site
213810000221	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
213810000222	Condensation domain; Region: Condensation; pfam00668
213810000223	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
213810000224	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
213810000225	active site
213810000226	ATP binding site [chemical binding]; other site
213810000227	Phosphotransferase enzyme family; Region: APH; pfam01636
213810000228	substrate binding site [chemical binding]; other site
213810000229	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
213810000230	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
213810000231	putative catalytic cysteine [active]
213810000232	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
213810000233	putative active site [active]
213810000234	metal binding site [ion binding]; metal-binding site
213810000235	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810000236	Double zinc ribbon; Region: DZR; pfam12773
213810000237	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810000238	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
213810000239	CotJB protein; Region: CotJB; pfam12652
213810000240	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
213810000241	dimanganese center [ion binding]; other site
213810000242	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
213810000243	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
213810000244	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
213810000245	Acyltransferase family; Region: Acyl_transf_3; pfam01757
213810000246	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
213810000247	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
213810000248	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
213810000249	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
213810000250	substrate binding site; other site
213810000251	dimer interface; other site
213810000252	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
213810000253	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
213810000254	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
213810000255	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
213810000256	putative trimer interface [polypeptide binding]; other site
213810000257	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
213810000258	trimer interface [polypeptide binding]; other site
213810000259	active site
213810000260	substrate binding site [chemical binding]; other site
213810000261	putative CoA binding site [chemical binding]; other site
213810000262	CoA binding site [chemical binding]; other site
213810000263	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
213810000264	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
213810000265	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
213810000266	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
213810000267	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
213810000268	NADP binding site [chemical binding]; other site
213810000269	active site
213810000270	putative substrate binding site [chemical binding]; other site
213810000271	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810000272	active site
213810000273	nucleotide binding site [chemical binding]; other site
213810000274	HIGH motif; other site
213810000275	KMSKS motif; other site
213810000276	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
213810000277	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
213810000278	NAD binding site [chemical binding]; other site
213810000279	substrate binding site [chemical binding]; other site
213810000280	homodimer interface [polypeptide binding]; other site
213810000281	active site
213810000282	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
213810000283	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
213810000284	substrate binding site; other site
213810000285	tetramer interface; other site
213810000286	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810000287	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
213810000288	catalytic residues [active]
213810000289	catalytic nucleophile [active]
213810000290	Presynaptic Site I dimer interface [polypeptide binding]; other site
213810000291	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
213810000292	Synaptic Flat tetramer interface [polypeptide binding]; other site
213810000293	Synaptic Site I dimer interface [polypeptide binding]; other site
213810000294	DNA binding site [nucleotide binding]
213810000295	Recombinase; Region: Recombinase; pfam07508
213810000296	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
213810000297	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
213810000298	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
213810000299	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
213810000300	homodecamer interface [polypeptide binding]; other site
213810000301	GTP cyclohydrolase I; Provisional; Region: PLN03044
213810000302	active site
213810000303	putative catalytic site residues [active]
213810000304	zinc binding site [ion binding]; other site
213810000305	GTP-CH-I/GFRP interaction surface; other site
213810000306	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810000307	Zn2+ binding site [ion binding]; other site
213810000308	Mg2+ binding site [ion binding]; other site
213810000309	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
213810000310	dihydropteroate synthase; Region: DHPS; TIGR01496
213810000311	substrate binding pocket [chemical binding]; other site
213810000312	dimer interface [polypeptide binding]; other site
213810000313	inhibitor binding site; inhibition site
213810000314	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
213810000315	homooctamer interface [polypeptide binding]; other site
213810000316	active site
213810000317	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
213810000318	catalytic center binding site [active]
213810000319	ATP binding site [chemical binding]; other site
213810000320	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
213810000321	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
213810000322	folate binding site [chemical binding]; other site
213810000323	NADP+ binding site [chemical binding]; other site
213810000324	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
213810000325	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
213810000326	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
213810000327	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
213810000328	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810000329	Coenzyme A binding pocket [chemical binding]; other site
213810000330	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
213810000331	endoglucanase; Region: PLN02308
213810000332	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
213810000333	Ferritin-like domain; Region: Ferritin; pfam00210
213810000334	ferroxidase diiron center [ion binding]; other site
213810000335	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
213810000336	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810000337	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
213810000338	cofactor binding site; other site
213810000339	DNA binding site [nucleotide binding]
213810000340	substrate interaction site [chemical binding]; other site
213810000341	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
213810000342	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
213810000343	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
213810000344	AAA domain; Region: AAA_21; pfam13304
213810000345	RloB-like protein; Region: RloB; pfam13707
213810000346	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810000347	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
213810000348	catalytic residues [active]
213810000349	catalytic nucleophile [active]
213810000350	Recombinase; Region: Recombinase; pfam07508
213810000351	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
213810000352	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810000353	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810000354	non-specific DNA binding site [nucleotide binding]; other site
213810000355	salt bridge; other site
213810000356	sequence-specific DNA binding site [nucleotide binding]; other site
213810000357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810000358	non-specific DNA binding site [nucleotide binding]; other site
213810000359	salt bridge; other site
213810000360	sequence-specific DNA binding site [nucleotide binding]; other site
213810000361	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810000362	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
213810000363	putative active site [active]
213810000364	putative metal binding site [ion binding]; other site
213810000365	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810000366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810000367	non-specific DNA binding site [nucleotide binding]; other site
213810000368	salt bridge; other site
213810000369	sequence-specific DNA binding site [nucleotide binding]; other site
213810000370	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
213810000371	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
213810000372	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810000373	cofactor binding site; other site
213810000374	DNA binding site [nucleotide binding]
213810000375	substrate interaction site [chemical binding]; other site
213810000376	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810000377	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
213810000378	DNA methylase; Region: N6_N4_Mtase; pfam01555
213810000379	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
213810000380	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
213810000381	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810000382	Int/Topo IB signature motif; other site
213810000383	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
213810000384	Low molecular weight phosphatase family; Region: LMWPc; cl00105
213810000385	active site
213810000386	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
213810000387	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
213810000388	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
213810000389	putative active site [active]
213810000390	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
213810000391	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810000392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810000393	Walker A/P-loop; other site
213810000394	ATP binding site [chemical binding]; other site
213810000395	Q-loop/lid; other site
213810000396	ABC transporter signature motif; other site
213810000397	Walker B; other site
213810000398	D-loop; other site
213810000399	H-loop/switch region; other site
213810000400	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
213810000401	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
213810000402	E3 interaction surface; other site
213810000403	lipoyl attachment site [posttranslational modification]; other site
213810000404	HlyD family secretion protein; Region: HlyD_3; pfam13437
213810000405	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
213810000406	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
213810000407	active site
213810000408	AAA domain; Region: AAA_21; pfam13304
213810000409	AAA domain; Region: AAA_21; pfam13304
213810000410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810000411	Walker B; other site
213810000412	D-loop; other site
213810000413	H-loop/switch region; other site
213810000414	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
213810000415	TIR domain; Region: TIR_2; pfam13676
213810000416	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
213810000417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810000418	non-specific DNA binding site [nucleotide binding]; other site
213810000419	salt bridge; other site
213810000420	sequence-specific DNA binding site [nucleotide binding]; other site
213810000421	glycyl-tRNA synthetase; Provisional; Region: PRK04173
213810000422	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
213810000423	motif 1; other site
213810000424	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
213810000425	active site
213810000426	motif 2; other site
213810000427	motif 3; other site
213810000428	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
213810000429	anticodon binding site; other site
213810000430	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
213810000431	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
213810000432	homodimer interface [polypeptide binding]; other site
213810000433	substrate-cofactor binding pocket; other site
213810000434	catalytic residue [active]
213810000435	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
213810000436	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
213810000437	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
213810000438	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
213810000439	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
213810000440	Walker A/P-loop; other site
213810000441	ATP binding site [chemical binding]; other site
213810000442	Q-loop/lid; other site
213810000443	ABC transporter signature motif; other site
213810000444	Walker B; other site
213810000445	D-loop; other site
213810000446	H-loop/switch region; other site
213810000447	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
213810000448	active site 1 [active]
213810000449	active site 2 [active]
213810000450	Sulfatase; Region: Sulfatase; cl17466
213810000451	hypothetical protein; Provisional; Region: PRK13670
213810000452	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
213810000453	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
213810000454	propionate/acetate kinase; Provisional; Region: PRK12379
213810000455	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
213810000456	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
213810000457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
213810000458	NAD(P) binding site [chemical binding]; other site
213810000459	active site
213810000460	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
213810000461	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
213810000462	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
213810000463	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
213810000464	active site
213810000465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810000466	salt bridge; other site
213810000467	non-specific DNA binding site [nucleotide binding]; other site
213810000468	sequence-specific DNA binding site [nucleotide binding]; other site
213810000469	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
213810000470	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
213810000471	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
213810000472	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
213810000473	active site
213810000474	Repair protein; Region: Repair_PSII; cl01535
213810000475	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
213810000476	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
213810000477	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
213810000478	active site
213810000479	catalytic residues [active]
213810000480	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
213810000481	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
213810000482	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
213810000483	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
213810000484	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
213810000485	dimer interface [polypeptide binding]; other site
213810000486	pyridoxal binding site [chemical binding]; other site
213810000487	ATP binding site [chemical binding]; other site
213810000488	Predicted methyltransferases [General function prediction only]; Region: COG0313
213810000489	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
213810000490	putative SAM binding site [chemical binding]; other site
213810000491	putative homodimer interface [polypeptide binding]; other site
213810000492	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
213810000493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810000494	S-adenosylmethionine binding site [chemical binding]; other site
213810000495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810000496	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
213810000497	active site
213810000498	motif I; other site
213810000499	motif II; other site
213810000500	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
213810000501	RNA methyltransferase, RsmE family; Region: TIGR00046
213810000502	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
213810000503	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
213810000504	generic binding surface II; other site
213810000505	ssDNA binding site; other site
213810000506	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
213810000507	ATP binding site [chemical binding]; other site
213810000508	putative Mg++ binding site [ion binding]; other site
213810000509	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
213810000510	nucleotide binding region [chemical binding]; other site
213810000511	ATP-binding site [chemical binding]; other site
213810000512	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
213810000513	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
213810000514	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810000515	putative active site [active]
213810000516	metal binding site [ion binding]; metal-binding site
213810000517	homodimer binding site [polypeptide binding]; other site
213810000518	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
213810000519	ANTAR domain; Region: ANTAR; pfam03861
213810000520	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
213810000521	domain_subunit interface; other site
213810000522	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
213810000523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
213810000524	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
213810000525	4Fe-4S binding domain; Region: Fer4; cl02805
213810000526	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810000527	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
213810000528	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
213810000529	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
213810000530	active site
213810000531	FMN binding site [chemical binding]; other site
213810000532	substrate binding site [chemical binding]; other site
213810000533	3Fe-4S cluster binding site [ion binding]; other site
213810000534	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
213810000535	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
213810000536	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
213810000537	putative active site [active]
213810000538	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
213810000539	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
213810000540	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
213810000541	ammonium transporter; Region: amt; TIGR00836
213810000542	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
213810000543	Nitrogen regulatory protein P-II; Region: P-II; smart00938
213810000544	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
213810000545	hypothetical protein; Provisional; Region: PRK05473
213810000546	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
213810000547	FAD binding site [chemical binding]; other site
213810000548	Asp23 family; Region: Asp23; pfam03780
213810000549	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
213810000550	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
213810000551	PemK-like protein; Region: PemK; pfam02452
213810000552	polyphosphate kinase; Provisional; Region: PRK05443
213810000553	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
213810000554	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
213810000555	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
213810000556	putative active site [active]
213810000557	catalytic site [active]
213810000558	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
213810000559	putative domain interface [polypeptide binding]; other site
213810000560	putative active site [active]
213810000561	catalytic site [active]
213810000562	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
213810000563	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
213810000564	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810000565	catalytic residue [active]
213810000566	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
213810000567	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
213810000568	Walker A/P-loop; other site
213810000569	ATP binding site [chemical binding]; other site
213810000570	Q-loop/lid; other site
213810000571	ABC transporter signature motif; other site
213810000572	Walker B; other site
213810000573	D-loop; other site
213810000574	H-loop/switch region; other site
213810000575	TOBE domain; Region: TOBE; pfam03459
213810000576	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
213810000577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810000578	RNA binding surface [nucleotide binding]; other site
213810000579	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
213810000580	active site
213810000581	uracil binding [chemical binding]; other site
213810000582	Predicted membrane protein [Function unknown]; Region: COG4818
213810000583	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
213810000584	ATP cone domain; Region: ATP-cone; pfam03477
213810000585	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
213810000586	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
213810000587	Protein export membrane protein; Region: SecD_SecF; cl14618
213810000588	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
213810000589	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
213810000590	tetramer interface [polypeptide binding]; other site
213810000591	active site
213810000592	YcxB-like protein; Region: YcxB; pfam14317
213810000593	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
213810000594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810000595	Mg2+ binding site [ion binding]; other site
213810000596	G-X-G motif; other site
213810000597	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
213810000598	anchoring element; other site
213810000599	dimer interface [polypeptide binding]; other site
213810000600	ATP binding site [chemical binding]; other site
213810000601	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
213810000602	active site
213810000603	putative metal-binding site [ion binding]; other site
213810000604	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
213810000605	recombination protein F; Reviewed; Region: recF; PRK00064
213810000606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810000607	Walker A/P-loop; other site
213810000608	ATP binding site [chemical binding]; other site
213810000609	Q-loop/lid; other site
213810000610	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810000611	ABC transporter signature motif; other site
213810000612	Walker B; other site
213810000613	D-loop; other site
213810000614	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810000615	RNA binding surface [nucleotide binding]; other site
213810000616	DNA polymerase III subunit beta; Validated; Region: PRK05643
213810000617	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
213810000618	putative DNA binding surface [nucleotide binding]; other site
213810000619	dimer interface [polypeptide binding]; other site
213810000620	beta-clamp/clamp loader binding surface; other site
213810000621	beta-clamp/translesion DNA polymerase binding surface; other site
213810000622	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
213810000623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810000624	Walker A motif; other site
213810000625	ATP binding site [chemical binding]; other site
213810000626	Walker B motif; other site
213810000627	arginine finger; other site
213810000628	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
213810000629	DnaA box-binding interface [nucleotide binding]; other site
213810000630	BNR repeat-like domain; Region: BNR_2; pfam13088
213810000631	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810000632	phage shock protein A; Region: phageshock_pspA; TIGR02977
213810000633	prolyl-tRNA synthetase; Provisional; Region: PRK08661
213810000634	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
213810000635	dimer interface [polypeptide binding]; other site
213810000636	motif 1; other site
213810000637	active site
213810000638	motif 2; other site
213810000639	motif 3; other site
213810000640	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
213810000641	anticodon binding site; other site
213810000642	zinc-binding site [ion binding]; other site
213810000643	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
213810000644	Phage terminase large subunit; Region: Terminase_3; cl12054
213810000645	Terminase-like family; Region: Terminase_6; pfam03237
213810000646	Terminase small subunit; Region: Terminase_2; cl01513
213810000647	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
213810000648	Ribonuclease P; Region: Ribonuclease_P; cl00457
213810000649	Haemolytic domain; Region: Haemolytic; pfam01809
213810000650	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
213810000651	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
213810000652	G-X-X-G motif; other site
213810000653	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
213810000654	RxxxH motif; other site
213810000655	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
213810000656	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
213810000657	trmE is a tRNA modification GTPase; Region: trmE; cd04164
213810000658	G1 box; other site
213810000659	GTP/Mg2+ binding site [chemical binding]; other site
213810000660	Switch I region; other site
213810000661	G2 box; other site
213810000662	Switch II region; other site
213810000663	G3 box; other site
213810000664	G4 box; other site
213810000665	G5 box; other site
213810000666	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
213810000667	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
213810000668	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
213810000669	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
213810000670	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
213810000671	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
213810000672	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
213810000673	ParB-like nuclease domain; Region: ParB; smart00470
213810000674	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
213810000675	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
213810000676	P-loop; other site
213810000677	Magnesium ion binding site [ion binding]; other site
213810000678	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
213810000679	Magnesium ion binding site [ion binding]; other site
213810000680	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
213810000681	ParB-like nuclease domain; Region: ParBc; pfam02195
213810000682	seryl-tRNA synthetase; Provisional; Region: PRK05431
213810000683	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
213810000684	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
213810000685	motif 1; other site
213810000686	dimer interface [polypeptide binding]; other site
213810000687	active site
213810000688	motif 2; other site
213810000689	motif 3; other site
213810000690	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
213810000691	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
213810000692	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
213810000693	G1 box; other site
213810000694	putative GEF interaction site [polypeptide binding]; other site
213810000695	GTP/Mg2+ binding site [chemical binding]; other site
213810000696	Switch I region; other site
213810000697	G2 box; other site
213810000698	G3 box; other site
213810000699	Switch II region; other site
213810000700	G4 box; other site
213810000701	G5 box; other site
213810000702	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
213810000703	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
213810000704	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
213810000705	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
213810000706	NADP-binding site; other site
213810000707	homotetramer interface [polypeptide binding]; other site
213810000708	substrate binding site [chemical binding]; other site
213810000709	homodimer interface [polypeptide binding]; other site
213810000710	active site
213810000711	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
213810000712	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
213810000713	putative ADP-binding pocket [chemical binding]; other site
213810000714	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
213810000715	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
213810000716	NADP-binding site; other site
213810000717	homotetramer interface [polypeptide binding]; other site
213810000718	substrate binding site [chemical binding]; other site
213810000719	homodimer interface [polypeptide binding]; other site
213810000720	active site
213810000721	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
213810000722	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
213810000723	Substrate binding site; other site
213810000724	Cupin domain; Region: Cupin_2; cl17218
213810000725	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
213810000726	Bacterial sugar transferase; Region: Bac_transf; pfam02397
213810000727	Domain of unknown function (DUF378); Region: DUF378; pfam04070
213810000728	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
213810000729	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
213810000730	nucleotide binding site [chemical binding]; other site
213810000731	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
213810000732	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
213810000733	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
213810000734	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
213810000735	active site
213810000736	VPS10 domain; Region: VPS10; smart00602
213810000737	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
213810000738	Melibiase; Region: Melibiase; pfam02065
213810000739	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
213810000740	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
213810000741	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
213810000742	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
213810000743	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
213810000744	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
213810000745	RNA/DNA hybrid binding site [nucleotide binding]; other site
213810000746	active site
213810000747	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
213810000748	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
213810000749	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810000750	catalytic residue [active]
213810000751	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
213810000752	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
213810000753	trimerization site [polypeptide binding]; other site
213810000754	active site
213810000755	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
213810000756	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
213810000757	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
213810000758	PhoU domain; Region: PhoU; pfam01895
213810000759	PhoU domain; Region: PhoU; pfam01895
213810000760	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
213810000761	Predicted membrane protein [Function unknown]; Region: COG2323
213810000762	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
213810000763	stage V sporulation protein AD; Validated; Region: PRK08304
213810000764	stage V sporulation protein AD; Provisional; Region: PRK12404
213810000765	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
213810000766	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
213810000767	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810000768	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
213810000769	Soluble P-type ATPase [General function prediction only]; Region: COG4087
213810000770	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
213810000771	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
213810000772	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
213810000773	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
213810000774	Catalytic site [active]
213810000775	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810000776	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
213810000777	UGMP family protein; Validated; Region: PRK09604
213810000778	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
213810000779	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
213810000780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810000781	Coenzyme A binding pocket [chemical binding]; other site
213810000782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
213810000783	DNA polymerase I; Provisional; Region: PRK05755
213810000784	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
213810000785	active site
213810000786	metal binding site 1 [ion binding]; metal-binding site
213810000787	putative 5' ssDNA interaction site; other site
213810000788	metal binding site 3; metal-binding site
213810000789	metal binding site 2 [ion binding]; metal-binding site
213810000790	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
213810000791	putative DNA binding site [nucleotide binding]; other site
213810000792	putative metal binding site [ion binding]; other site
213810000793	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
213810000794	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
213810000795	active site
213810000796	DNA binding site [nucleotide binding]
213810000797	catalytic site [active]
213810000798	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
213810000799	MarR family; Region: MarR; pfam01047
213810000800	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
213810000801	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
213810000802	GrpE; Region: GrpE; pfam01025
213810000803	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
213810000804	dimer interface [polypeptide binding]; other site
213810000805	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
213810000806	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
213810000807	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
213810000808	nucleotide binding site [chemical binding]; other site
213810000809	NEF interaction site [polypeptide binding]; other site
213810000810	SBD interface [polypeptide binding]; other site
213810000811	chaperone protein DnaJ; Provisional; Region: PRK10767
213810000812	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
213810000813	HSP70 interaction site [polypeptide binding]; other site
213810000814	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
213810000815	Zn binding sites [ion binding]; other site
213810000816	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
213810000817	dimer interface [polypeptide binding]; other site
213810000818	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
213810000819	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
213810000820	putative valine binding site [chemical binding]; other site
213810000821	dimer interface [polypeptide binding]; other site
213810000822	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
213810000823	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
213810000824	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
213810000825	PYR/PP interface [polypeptide binding]; other site
213810000826	dimer interface [polypeptide binding]; other site
213810000827	TPP binding site [chemical binding]; other site
213810000828	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
213810000829	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
213810000830	TPP-binding site [chemical binding]; other site
213810000831	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
213810000832	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
213810000833	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
213810000834	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
213810000835	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
213810000836	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
213810000837	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
213810000838	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
213810000839	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
213810000840	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
213810000841	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
213810000842	Walker A motif; other site
213810000843	ATP binding site [chemical binding]; other site
213810000844	Walker B motif; other site
213810000845	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
213810000846	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
213810000847	Walker A motif; other site
213810000848	ATP binding site [chemical binding]; other site
213810000849	Walker B motif; other site
213810000850	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
213810000851	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
213810000852	Methyltransferase domain; Region: Methyltransf_31; pfam13847
213810000853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810000854	S-adenosylmethionine binding site [chemical binding]; other site
213810000855	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
213810000856	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
213810000857	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
213810000858	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
213810000859	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
213810000860	DNA binding residues [nucleotide binding]
213810000861	dimer interface [polypeptide binding]; other site
213810000862	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
213810000863	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
213810000864	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
213810000865	active site
213810000866	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
213810000867	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
213810000868	active site
213810000869	HIGH motif; other site
213810000870	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
213810000871	KMSKS motif; other site
213810000872	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
213810000873	tRNA binding surface [nucleotide binding]; other site
213810000874	anticodon binding site; other site
213810000875	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
213810000876	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
213810000877	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
213810000878	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810000879	FeS/SAM binding site; other site
213810000880	RecX family; Region: RecX; pfam02631
213810000881	recombinase A; Provisional; Region: recA; PRK09354
213810000882	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
213810000883	hexamer interface [polypeptide binding]; other site
213810000884	Walker A motif; other site
213810000885	ATP binding site [chemical binding]; other site
213810000886	Walker B motif; other site
213810000887	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
213810000888	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810000889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
213810000890	dimerization interface [polypeptide binding]; other site
213810000891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810000892	dimer interface [polypeptide binding]; other site
213810000893	phosphorylation site [posttranslational modification]
213810000894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810000895	ATP binding site [chemical binding]; other site
213810000896	Mg2+ binding site [ion binding]; other site
213810000897	G-X-G motif; other site
213810000898	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
213810000899	dimer interface [polypeptide binding]; other site
213810000900	Citrate synthase; Region: Citrate_synt; pfam00285
213810000901	active site
213810000902	citrylCoA binding site [chemical binding]; other site
213810000903	oxalacetate/citrate binding site [chemical binding]; other site
213810000904	coenzyme A binding site [chemical binding]; other site
213810000905	catalytic triad [active]
213810000906	Nuclease-related domain; Region: NERD; pfam08378
213810000907	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
213810000908	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
213810000909	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
213810000910	Cl- selectivity filter; other site
213810000911	Cl- binding residues [ion binding]; other site
213810000912	pore gating glutamate residue; other site
213810000913	dimer interface [polypeptide binding]; other site
213810000914	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
213810000915	PAS domain; Region: PAS; smart00091
213810000916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810000917	dimer interface [polypeptide binding]; other site
213810000918	phosphorylation site [posttranslational modification]
213810000919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810000920	ATP binding site [chemical binding]; other site
213810000921	Mg2+ binding site [ion binding]; other site
213810000922	G-X-G motif; other site
213810000923	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810000924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810000925	active site
213810000926	phosphorylation site [posttranslational modification]
213810000927	intermolecular recognition site; other site
213810000928	dimerization interface [polypeptide binding]; other site
213810000929	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810000930	DNA binding site [nucleotide binding]
213810000931	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
213810000932	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
213810000933	ribonuclease R; Region: RNase_R; TIGR02063
213810000934	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
213810000935	RNB domain; Region: RNB; pfam00773
213810000936	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
213810000937	RNA binding site [nucleotide binding]; other site
213810000938	Preprotein translocase SecG subunit; Region: SecG; cl09123
213810000939	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
213810000940	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
213810000941	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
213810000942	homodimer interface [polypeptide binding]; other site
213810000943	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
213810000944	substrate-cofactor binding pocket; other site
213810000945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810000946	catalytic residue [active]
213810000947	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
213810000948	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
213810000949	putative ligand binding site [chemical binding]; other site
213810000950	putative NAD binding site [chemical binding]; other site
213810000951	putative catalytic site [active]
213810000952	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
213810000953	L-serine binding site [chemical binding]; other site
213810000954	ACT domain interface; other site
213810000955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810000956	metal binding site [ion binding]; metal-binding site
213810000957	active site
213810000958	I-site; other site
213810000959	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
213810000960	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
213810000961	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810000962	CAAX protease self-immunity; Region: Abi; pfam02517
213810000963	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
213810000964	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
213810000965	G1 box; other site
213810000966	GTP/Mg2+ binding site [chemical binding]; other site
213810000967	G2 box; other site
213810000968	Switch I region; other site
213810000969	G3 box; other site
213810000970	Switch II region; other site
213810000971	G4 box; other site
213810000972	G5 box; other site
213810000973	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
213810000974	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
213810000975	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
213810000976	putative alpha-glucosidase; Provisional; Region: PRK10658
213810000977	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
213810000978	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
213810000979	active site
213810000980	homotrimer interface [polypeptide binding]; other site
213810000981	catalytic site [active]
213810000982	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
213810000983	Bacterial PH domain; Region: DUF304; pfam03703
213810000984	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
213810000985	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
213810000986	nudix motif; other site
213810000987	TM2 domain; Region: TM2; pfam05154
213810000988	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
213810000989	Clp amino terminal domain; Region: Clp_N; pfam02861
213810000990	Clp amino terminal domain; Region: Clp_N; pfam02861
213810000991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810000992	Walker A motif; other site
213810000993	ATP binding site [chemical binding]; other site
213810000994	Walker B motif; other site
213810000995	arginine finger; other site
213810000996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810000997	Walker A motif; other site
213810000998	ATP binding site [chemical binding]; other site
213810000999	Walker B motif; other site
213810001000	arginine finger; other site
213810001001	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
213810001002	LexA regulated protein; Provisional; Region: PRK11675
213810001003	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
213810001004	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
213810001005	catalytic core [active]
213810001006	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810001007	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810001008	non-specific DNA binding site [nucleotide binding]; other site
213810001009	salt bridge; other site
213810001010	sequence-specific DNA binding site [nucleotide binding]; other site
213810001011	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
213810001012	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
213810001013	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810001014	putative active site [active]
213810001015	putative metal binding site [ion binding]; other site
213810001016	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
213810001017	active site
213810001018	catalytic triad [active]
213810001019	oxyanion hole [active]
213810001020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
213810001021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
213810001022	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
213810001023	dimerization interface [polypeptide binding]; other site
213810001024	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
213810001025	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810001026	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810001027	metal binding site [ion binding]; metal-binding site
213810001028	active site
213810001029	I-site; other site
213810001030	Predicted membrane protein [Function unknown]; Region: COG1971
213810001031	Domain of unknown function DUF; Region: DUF204; pfam02659
213810001032	Domain of unknown function DUF; Region: DUF204; pfam02659
213810001033	Smr domain; Region: Smr; pfam01713
213810001034	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
213810001035	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
213810001036	FMN binding site [chemical binding]; other site
213810001037	active site
213810001038	catalytic residues [active]
213810001039	substrate binding site [chemical binding]; other site
213810001040	Predicted membrane protein [Function unknown]; Region: COG2246
213810001041	GtrA-like protein; Region: GtrA; pfam04138
213810001042	Domain of unknown function DUF21; Region: DUF21; pfam01595
213810001043	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
213810001044	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
213810001045	Transporter associated domain; Region: CorC_HlyC; smart01091
213810001046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
213810001047	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
213810001048	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
213810001049	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
213810001050	Ca2+ binding site [ion binding]; other site
213810001051	Family description; Region: VCBS; pfam13517
213810001052	AAA domain; Region: AAA_31; pfam13614
213810001053	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
213810001054	P-loop; other site
213810001055	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
213810001056	Magnesium ion binding site [ion binding]; other site
213810001057	CAAX protease self-immunity; Region: Abi; pfam02517
213810001058	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
213810001059	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810001060	Walker A/P-loop; other site
213810001061	ATP binding site [chemical binding]; other site
213810001062	Q-loop/lid; other site
213810001063	ABC transporter signature motif; other site
213810001064	Walker B; other site
213810001065	D-loop; other site
213810001066	H-loop/switch region; other site
213810001067	Predicted transcriptional regulators [Transcription]; Region: COG1725
213810001068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
213810001069	DNA-binding site [nucleotide binding]; DNA binding site
213810001070	aspartate kinase; Reviewed; Region: PRK09034
213810001071	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
213810001072	nucleotide binding site [chemical binding]; other site
213810001073	substrate binding site [chemical binding]; other site
213810001074	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
213810001075	allosteric regulatory residue; other site
213810001076	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
213810001077	ribosome maturation protein RimP; Reviewed; Region: PRK00092
213810001078	Sm and related proteins; Region: Sm_like; cl00259
213810001079	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
213810001080	putative oligomer interface [polypeptide binding]; other site
213810001081	putative RNA binding site [nucleotide binding]; other site
213810001082	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
213810001083	NusA N-terminal domain; Region: NusA_N; pfam08529
213810001084	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
213810001085	RNA binding site [nucleotide binding]; other site
213810001086	homodimer interface [polypeptide binding]; other site
213810001087	NusA-like KH domain; Region: KH_5; pfam13184
213810001088	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
213810001089	G-X-X-G motif; other site
213810001090	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
213810001091	putative RNA binding cleft [nucleotide binding]; other site
213810001092	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
213810001093	translation initiation factor IF-2; Region: IF-2; TIGR00487
213810001094	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
213810001095	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
213810001096	G1 box; other site
213810001097	putative GEF interaction site [polypeptide binding]; other site
213810001098	GTP/Mg2+ binding site [chemical binding]; other site
213810001099	Switch I region; other site
213810001100	G2 box; other site
213810001101	G3 box; other site
213810001102	Switch II region; other site
213810001103	G4 box; other site
213810001104	G5 box; other site
213810001105	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
213810001106	Translation-initiation factor 2; Region: IF-2; pfam11987
213810001107	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
213810001108	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
213810001109	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
213810001110	DHH family; Region: DHH; pfam01368
213810001111	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
213810001112	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
213810001113	RNA binding site [nucleotide binding]; other site
213810001114	active site
213810001115	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
213810001116	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
213810001117	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
213810001118	active site
213810001119	HIGH motif; other site
213810001120	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
213810001121	active site
213810001122	KMSKS motif; other site
213810001123	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
213810001124	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810001125	Walker A/P-loop; other site
213810001126	ATP binding site [chemical binding]; other site
213810001127	Q-loop/lid; other site
213810001128	ABC transporter signature motif; other site
213810001129	Walker B; other site
213810001130	D-loop; other site
213810001131	H-loop/switch region; other site
213810001132	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
213810001133	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
213810001134	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
213810001135	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
213810001136	pyruvate phosphate dikinase; Provisional; Region: PRK09279
213810001137	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
213810001138	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
213810001139	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
213810001140	Chloramphenicol acetyltransferase; Region: CAT; cl02008
213810001141	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
213810001142	trimer interface [polypeptide binding]; other site
213810001143	active site
213810001144	substrate binding site [chemical binding]; other site
213810001145	CoA binding site [chemical binding]; other site
213810001146	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
213810001147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810001148	Coenzyme A binding pocket [chemical binding]; other site
213810001149	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
213810001150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
213810001151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
213810001152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
213810001153	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
213810001154	active site
213810001155	catalytic site [active]
213810001156	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
213810001157	domain interaction interfaces [polypeptide binding]; other site
213810001158	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
213810001159	Cna protein B-type domain; Region: Cna_B; pfam05738
213810001160	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
213810001161	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
213810001162	domain interaction interfaces [polypeptide binding]; other site
213810001163	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
213810001164	domain interaction interfaces [polypeptide binding]; other site
213810001165	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
213810001166	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
213810001167	Catalytic site [active]
213810001168	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
213810001169	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810001170	Coenzyme A binding pocket [chemical binding]; other site
213810001171	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
213810001172	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
213810001173	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
213810001174	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
213810001175	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
213810001176	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810001177	Zn2+ binding site [ion binding]; other site
213810001178	Mg2+ binding site [ion binding]; other site
213810001179	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
213810001180	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
213810001181	active site
213810001182	dimer interface [polypeptide binding]; other site
213810001183	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
213810001184	Ligand Binding Site [chemical binding]; other site
213810001185	Molecular Tunnel; other site
213810001186	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
213810001187	active site
213810001188	catalytic triad [active]
213810001189	oxyanion hole [active]
213810001190	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
213810001191	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
213810001192	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
213810001193	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
213810001194	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
213810001195	GTP-binding protein Der; Reviewed; Region: PRK00093
213810001196	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
213810001197	G1 box; other site
213810001198	GTP/Mg2+ binding site [chemical binding]; other site
213810001199	Switch I region; other site
213810001200	G2 box; other site
213810001201	Switch II region; other site
213810001202	G3 box; other site
213810001203	G4 box; other site
213810001204	G5 box; other site
213810001205	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
213810001206	G1 box; other site
213810001207	GTP/Mg2+ binding site [chemical binding]; other site
213810001208	Switch I region; other site
213810001209	G2 box; other site
213810001210	G3 box; other site
213810001211	Switch II region; other site
213810001212	G4 box; other site
213810001213	G5 box; other site
213810001214	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
213810001215	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
213810001216	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
213810001217	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
213810001218	active site
213810001219	dimer interface [polypeptide binding]; other site
213810001220	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
213810001221	dimer interface [polypeptide binding]; other site
213810001222	active site
213810001223	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
213810001224	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
213810001225	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
213810001226	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
213810001227	regulatory protein interface [polypeptide binding]; other site
213810001228	regulatory phosphorylation site [posttranslational modification]; other site
213810001229	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
213810001230	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
213810001231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810001232	FeS/SAM binding site; other site
213810001233	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
213810001234	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
213810001235	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
213810001236	dimerization interface [polypeptide binding]; other site
213810001237	ATP binding site [chemical binding]; other site
213810001238	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
213810001239	dimerization interface [polypeptide binding]; other site
213810001240	ATP binding site [chemical binding]; other site
213810001241	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
213810001242	putative active site [active]
213810001243	catalytic triad [active]
213810001244	Transglycosylase; Region: Transgly; pfam00912
213810001245	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
213810001246	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
213810001247	Flavoprotein; Region: Flavoprotein; cl08021
213810001248	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
213810001249	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
213810001250	NAD binding site [chemical binding]; other site
213810001251	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
213810001252	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
213810001253	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
213810001254	protein binding site [polypeptide binding]; other site
213810001255	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
213810001256	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
213810001257	active site
213810001258	NTP binding site [chemical binding]; other site
213810001259	metal binding triad [ion binding]; metal-binding site
213810001260	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
213810001261	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810001262	Zn2+ binding site [ion binding]; other site
213810001263	Mg2+ binding site [ion binding]; other site
213810001264	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
213810001265	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
213810001266	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
213810001267	ring oligomerisation interface [polypeptide binding]; other site
213810001268	ATP/Mg binding site [chemical binding]; other site
213810001269	stacking interactions; other site
213810001270	hinge regions; other site
213810001271	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
213810001272	oligomerisation interface [polypeptide binding]; other site
213810001273	mobile loop; other site
213810001274	roof hairpin; other site
213810001275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810001276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810001277	active site
213810001278	phosphorylation site [posttranslational modification]
213810001279	intermolecular recognition site; other site
213810001280	dimerization interface [polypeptide binding]; other site
213810001281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810001282	DNA binding site [nucleotide binding]
213810001283	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810001284	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
213810001285	dimerization interface [polypeptide binding]; other site
213810001286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810001287	dimer interface [polypeptide binding]; other site
213810001288	phosphorylation site [posttranslational modification]
213810001289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810001290	ATP binding site [chemical binding]; other site
213810001291	Mg2+ binding site [ion binding]; other site
213810001292	G-X-G motif; other site
213810001293	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
213810001294	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
213810001295	protein binding site [polypeptide binding]; other site
213810001296	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
213810001297	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
213810001298	YabP family; Region: YabP; cl06766
213810001299	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
213810001300	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
213810001301	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
213810001302	RNA binding site [nucleotide binding]; other site
213810001303	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
213810001304	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
213810001305	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810001306	Double zinc ribbon; Region: DZR; pfam12773
213810001307	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
213810001308	TM2 domain; Region: TM2; pfam05154
213810001309	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810001310	NPCBM/NEW2 domain; Region: NPCBM; cl07060
213810001311	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810001312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810001313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810001314	ATP binding site [chemical binding]; other site
213810001315	Mg2+ binding site [ion binding]; other site
213810001316	G-X-G motif; other site
213810001317	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
213810001318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810001319	active site
213810001320	phosphorylation site [posttranslational modification]
213810001321	intermolecular recognition site; other site
213810001322	dimerization interface [polypeptide binding]; other site
213810001323	LytTr DNA-binding domain; Region: LytTR; smart00850
213810001324	stage V sporulation protein T; Region: spore_V_T; TIGR02851
213810001325	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
213810001326	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
213810001327	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810001328	Walker A/P-loop; other site
213810001329	ATP binding site [chemical binding]; other site
213810001330	Q-loop/lid; other site
213810001331	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
213810001332	ABC transporter signature motif; other site
213810001333	Walker B; other site
213810001334	D-loop; other site
213810001335	H-loop/switch region; other site
213810001336	exonuclease subunit SbcD; Provisional; Region: PRK10966
213810001337	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
213810001338	active site
213810001339	metal binding site [ion binding]; metal-binding site
213810001340	DNA binding site [nucleotide binding]
213810001341	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
213810001342	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
213810001343	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
213810001344	active site
213810001345	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
213810001346	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
213810001347	BioY family; Region: BioY; pfam02632
213810001348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810001349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810001350	active site
213810001351	phosphorylation site [posttranslational modification]
213810001352	intermolecular recognition site; other site
213810001353	dimerization interface [polypeptide binding]; other site
213810001354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810001355	DNA binding site [nucleotide binding]
213810001356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810001357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810001358	dimer interface [polypeptide binding]; other site
213810001359	phosphorylation site [posttranslational modification]
213810001360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810001361	ATP binding site [chemical binding]; other site
213810001362	Mg2+ binding site [ion binding]; other site
213810001363	G-X-G motif; other site
213810001364	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
213810001365	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
213810001366	acyl-activating enzyme (AAE) consensus motif; other site
213810001367	AMP binding site [chemical binding]; other site
213810001368	Phosphopantetheine attachment site; Region: PP-binding; cl09936
213810001369	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
213810001370	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
213810001371	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
213810001372	transmembrane helices; other site
213810001373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810001374	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
213810001375	Coenzyme A binding pocket [chemical binding]; other site
213810001376	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
213810001377	catalytic core [active]
213810001378	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810001379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810001380	active site
213810001381	phosphorylation site [posttranslational modification]
213810001382	intermolecular recognition site; other site
213810001383	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
213810001384	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
213810001385	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
213810001386	MarR family; Region: MarR_2; pfam12802
213810001387	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
213810001388	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
213810001389	Walker A/P-loop; other site
213810001390	ATP binding site [chemical binding]; other site
213810001391	Q-loop/lid; other site
213810001392	ABC transporter signature motif; other site
213810001393	Walker B; other site
213810001394	D-loop; other site
213810001395	H-loop/switch region; other site
213810001396	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
213810001397	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
213810001398	von Willebrand factor type A domain; Region: VWA_2; pfam13519
213810001399	metal ion-dependent adhesion site (MIDAS); other site
213810001400	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
213810001401	putative ADP-ribose binding site [chemical binding]; other site
213810001402	putative active site [active]
213810001403	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
213810001404	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
213810001405	Catalytic site [active]
213810001406	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
213810001407	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
213810001408	domain interaction interfaces [polypeptide binding]; other site
213810001409	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810001410	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
213810001411	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
213810001412	active site
213810001413	catalytic site [active]
213810001414	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
213810001415	domain interaction interfaces [polypeptide binding]; other site
213810001416	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
213810001417	active site
213810001418	catalytic site [active]
213810001419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810001420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810001421	metal binding site [ion binding]; metal-binding site
213810001422	active site
213810001423	I-site; other site
213810001424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
213810001425	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
213810001426	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810001427	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
213810001428	Ca binding site [ion binding]; other site
213810001429	Ca binding site (active) [ion binding]; other site
213810001430	ligand binding site [chemical binding]; other site
213810001431	Double zinc ribbon; Region: DZR; pfam12773
213810001432	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
213810001433	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810001434	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
213810001435	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
213810001436	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810001437	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810001438	acyl-activating enzyme (AAE) consensus motif; other site
213810001439	AMP binding site [chemical binding]; other site
213810001440	active site
213810001441	CoA binding site [chemical binding]; other site
213810001442	Transcriptional regulators [Transcription]; Region: PurR; COG1609
213810001443	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
213810001444	DNA binding site [nucleotide binding]
213810001445	domain linker motif; other site
213810001446	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
213810001447	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
213810001448	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810001449	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810001450	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810001451	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
213810001452	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
213810001453	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
213810001454	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
213810001455	active site
213810001456	active site
213810001457	catalytic residues [active]
213810001458	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
213810001459	AzlC protein; Region: AzlC; pfam03591
213810001460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
213810001461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
213810001462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
213810001463	dimerization interface [polypeptide binding]; other site
213810001464	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
213810001465	active site
213810001466	catalytic triad [active]
213810001467	oxyanion hole [active]
213810001468	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
213810001469	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
213810001470	active site 2 [active]
213810001471	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
213810001472	active site
213810001473	catalytic triad [active]
213810001474	oxyanion hole [active]
213810001475	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
213810001476	putative homodimer interface [polypeptide binding]; other site
213810001477	putative homotetramer interface [polypeptide binding]; other site
213810001478	putative allosteric switch controlling residues; other site
213810001479	putative metal binding site [ion binding]; other site
213810001480	putative homodimer-homodimer interface [polypeptide binding]; other site
213810001481	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
213810001482	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
213810001483	metal-binding site [ion binding]
213810001484	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810001485	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810001486	motif II; other site
213810001487	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
213810001488	metal-binding site [ion binding]
213810001489	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
213810001490	metal-binding site [ion binding]
213810001491	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
213810001492	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
213810001493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810001494	Walker A/P-loop; other site
213810001495	ATP binding site [chemical binding]; other site
213810001496	Q-loop/lid; other site
213810001497	ABC transporter signature motif; other site
213810001498	Walker B; other site
213810001499	D-loop; other site
213810001500	H-loop/switch region; other site
213810001501	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
213810001502	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
213810001503	active site
213810001504	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
213810001505	substrate binding site [chemical binding]; other site
213810001506	catalytic residues [active]
213810001507	dimer interface [polypeptide binding]; other site
213810001508	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
213810001509	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
213810001510	C-terminal domain interface [polypeptide binding]; other site
213810001511	sugar binding site [chemical binding]; other site
213810001512	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
213810001513	PBP superfamily domain; Region: PBP_like_2; cl17296
213810001514	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
213810001515	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
213810001516	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
213810001517	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
213810001518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810001519	Walker A/P-loop; other site
213810001520	ATP binding site [chemical binding]; other site
213810001521	Q-loop/lid; other site
213810001522	ABC transporter signature motif; other site
213810001523	Walker B; other site
213810001524	D-loop; other site
213810001525	H-loop/switch region; other site
213810001526	FeoA domain; Region: FeoA; pfam04023
213810001527	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
213810001528	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
213810001529	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
213810001530	G1 box; other site
213810001531	GTP/Mg2+ binding site [chemical binding]; other site
213810001532	Switch I region; other site
213810001533	G2 box; other site
213810001534	G3 box; other site
213810001535	Switch II region; other site
213810001536	G4 box; other site
213810001537	G5 box; other site
213810001538	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
213810001539	Nucleoside recognition; Region: Gate; pfam07670
213810001540	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
213810001541	Nucleoside recognition; Region: Gate; pfam07670
213810001542	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
213810001543	active site
213810001544	catalytic triad [active]
213810001545	oxyanion hole [active]
213810001546	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
213810001547	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
213810001548	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
213810001549	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
213810001550	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810001551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810001552	non-specific DNA binding site [nucleotide binding]; other site
213810001553	salt bridge; other site
213810001554	sequence-specific DNA binding site [nucleotide binding]; other site
213810001555	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
213810001556	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810001557	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
213810001558	Cell division protein ZapA; Region: ZapA; pfam05164
213810001559	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
213810001560	Peptidase family U32; Region: Peptidase_U32; pfam01136
213810001561	Collagenase; Region: DUF3656; pfam12392
213810001562	Peptidase family U32; Region: Peptidase_U32; cl03113
213810001563	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
213810001564	trimer interface [polypeptide binding]; other site
213810001565	active site
213810001566	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
213810001567	rod shape-determining protein MreB; Provisional; Region: PRK13927
213810001568	MreB and similar proteins; Region: MreB_like; cd10225
213810001569	nucleotide binding site [chemical binding]; other site
213810001570	Mg binding site [ion binding]; other site
213810001571	putative protofilament interaction site [polypeptide binding]; other site
213810001572	RodZ interaction site [polypeptide binding]; other site
213810001573	rod shape-determining protein MreC; Provisional; Region: PRK13922
213810001574	rod shape-determining protein MreC; Region: MreC; pfam04085
213810001575	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
213810001576	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
213810001577	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
213810001578	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
213810001579	septum site-determining protein MinD; Region: minD_bact; TIGR01968
213810001580	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
213810001581	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
213810001582	substrate binding site [chemical binding]; other site
213810001583	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
213810001584	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
213810001585	dimer interface [polypeptide binding]; other site
213810001586	motif 1; other site
213810001587	active site
213810001588	motif 2; other site
213810001589	motif 3; other site
213810001590	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
213810001591	anticodon binding site; other site
213810001592	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
213810001593	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
213810001594	dimer interface [polypeptide binding]; other site
213810001595	anticodon binding site; other site
213810001596	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
213810001597	homodimer interface [polypeptide binding]; other site
213810001598	motif 1; other site
213810001599	active site
213810001600	motif 2; other site
213810001601	GAD domain; Region: GAD; pfam02938
213810001602	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
213810001603	active site
213810001604	motif 3; other site
213810001605	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
213810001606	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
213810001607	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
213810001608	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
213810001609	putative DNA binding site [nucleotide binding]; other site
213810001610	putative Zn2+ binding site [ion binding]; other site
213810001611	AsnC family; Region: AsnC_trans_reg; pfam01037
213810001612	histidinol-phosphatase; Provisional; Region: PRK05588
213810001613	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
213810001614	active site
213810001615	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
213810001616	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
213810001617	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
213810001618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810001619	FeS/SAM binding site; other site
213810001620	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
213810001621	Pyruvate formate lyase 1; Region: PFL1; cd01678
213810001622	coenzyme A binding site [chemical binding]; other site
213810001623	active site
213810001624	catalytic residues [active]
213810001625	glycine loop; other site
213810001626	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
213810001627	catalytic motif [active]
213810001628	Zn binding site [ion binding]; other site
213810001629	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
213810001630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810001631	S-adenosylmethionine binding site [chemical binding]; other site
213810001632	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
213810001633	glycogen branching enzyme; Provisional; Region: PRK12313
213810001634	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
213810001635	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
213810001636	active site
213810001637	catalytic site [active]
213810001638	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
213810001639	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
213810001640	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
213810001641	ligand binding site; other site
213810001642	oligomer interface; other site
213810001643	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
213810001644	dimer interface [polypeptide binding]; other site
213810001645	N-terminal domain interface [polypeptide binding]; other site
213810001646	sulfate 1 binding site; other site
213810001647	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
213810001648	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
213810001649	ligand binding site; other site
213810001650	oligomer interface; other site
213810001651	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
213810001652	dimer interface [polypeptide binding]; other site
213810001653	N-terminal domain interface [polypeptide binding]; other site
213810001654	sulfate 1 binding site; other site
213810001655	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
213810001656	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810001657	Dockerin type I repeat; Region: Dockerin_1; pfam00404
213810001658	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
213810001659	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
213810001660	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810001661	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
213810001662	acyl-activating enzyme (AAE) consensus motif; other site
213810001663	AMP binding site [chemical binding]; other site
213810001664	active site
213810001665	CoA binding site [chemical binding]; other site
213810001666	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
213810001667	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
213810001668	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
213810001669	dimer interface [polypeptide binding]; other site
213810001670	PYR/PP interface [polypeptide binding]; other site
213810001671	TPP binding site [chemical binding]; other site
213810001672	substrate binding site [chemical binding]; other site
213810001673	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
213810001674	TPP-binding site; other site
213810001675	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
213810001676	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
213810001677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810001678	dimer interface [polypeptide binding]; other site
213810001679	conserved gate region; other site
213810001680	ABC-ATPase subunit interface; other site
213810001681	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
213810001682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810001683	dimer interface [polypeptide binding]; other site
213810001684	conserved gate region; other site
213810001685	putative PBP binding loops; other site
213810001686	ABC-ATPase subunit interface; other site
213810001687	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
213810001688	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
213810001689	Walker A/P-loop; other site
213810001690	ATP binding site [chemical binding]; other site
213810001691	Q-loop/lid; other site
213810001692	ABC transporter signature motif; other site
213810001693	Walker B; other site
213810001694	D-loop; other site
213810001695	H-loop/switch region; other site
213810001696	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
213810001697	PhoU domain; Region: PhoU; pfam01895
213810001698	PhoU domain; Region: PhoU; pfam01895
213810001699	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
213810001700	PAS domain; Region: PAS; smart00091
213810001701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810001702	dimer interface [polypeptide binding]; other site
213810001703	phosphorylation site [posttranslational modification]
213810001704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810001705	ATP binding site [chemical binding]; other site
213810001706	Mg2+ binding site [ion binding]; other site
213810001707	G-X-G motif; other site
213810001708	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
213810001709	core dimer interface [polypeptide binding]; other site
213810001710	peripheral dimer interface [polypeptide binding]; other site
213810001711	L10 interface [polypeptide binding]; other site
213810001712	L11 interface [polypeptide binding]; other site
213810001713	putative EF-Tu interaction site [polypeptide binding]; other site
213810001714	putative EF-G interaction site [polypeptide binding]; other site
213810001715	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
213810001716	23S rRNA interface [nucleotide binding]; other site
213810001717	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
213810001718	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
213810001719	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
213810001720	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
213810001721	Putative Fe-S cluster; Region: FeS; cl17515
213810001722	PAS fold; Region: PAS; pfam00989
213810001723	PAS domain; Region: PAS; smart00091
213810001724	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
213810001725	dimer interface [polypeptide binding]; other site
213810001726	[2Fe-2S] cluster binding site [ion binding]; other site
213810001727	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
213810001728	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
213810001729	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
213810001730	Walker A/P-loop; other site
213810001731	ATP binding site [chemical binding]; other site
213810001732	Q-loop/lid; other site
213810001733	ABC transporter signature motif; other site
213810001734	Walker B; other site
213810001735	D-loop; other site
213810001736	H-loop/switch region; other site
213810001737	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
213810001738	Pectate lyase; Region: Pec_lyase_C; cl01593
213810001739	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810001740	putative sugar binding sites [chemical binding]; other site
213810001741	Q-X-W motif; other site
213810001742	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
213810001743	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
213810001744	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810001745	putative sugar binding sites [chemical binding]; other site
213810001746	Q-X-W motif; other site
213810001747	SseB protein; Region: SseB; cl06279
213810001748	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
213810001749	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
213810001750	active site
213810001751	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
213810001752	FAD binding site [chemical binding]; other site
213810001753	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
213810001754	CoenzymeA binding site [chemical binding]; other site
213810001755	subunit interaction site [polypeptide binding]; other site
213810001756	PHB binding site; other site
213810001757	GTP-binding protein YchF; Reviewed; Region: PRK09601
213810001758	YchF GTPase; Region: YchF; cd01900
213810001759	G1 box; other site
213810001760	GTP/Mg2+ binding site [chemical binding]; other site
213810001761	Switch I region; other site
213810001762	G2 box; other site
213810001763	Switch II region; other site
213810001764	G3 box; other site
213810001765	G4 box; other site
213810001766	G5 box; other site
213810001767	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
213810001768	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
213810001769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
213810001770	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
213810001771	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
213810001772	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
213810001773	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
213810001774	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
213810001775	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
213810001776	DHH family; Region: DHH; pfam01368
213810001777	DHHA1 domain; Region: DHHA1; pfam02272
213810001778	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
213810001779	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810001780	Zn2+ binding site [ion binding]; other site
213810001781	Mg2+ binding site [ion binding]; other site
213810001782	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
213810001783	synthetase active site [active]
213810001784	NTP binding site [chemical binding]; other site
213810001785	metal binding site [ion binding]; metal-binding site
213810001786	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
213810001787	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
213810001788	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
213810001789	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
213810001790	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
213810001791	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
213810001792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810001793	S-adenosylmethionine binding site [chemical binding]; other site
213810001794	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
213810001795	Catalytic domain of Protein Kinases; Region: PKc; cd00180
213810001796	active site
213810001797	ATP binding site [chemical binding]; other site
213810001798	substrate binding site [chemical binding]; other site
213810001799	activation loop (A-loop); other site
213810001800	PrcB C-terminal; Region: PrcB_C; pfam14343
213810001801	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
213810001802	putative ADP-ribose binding site [chemical binding]; other site
213810001803	putative active site [active]
213810001804	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
213810001805	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
213810001806	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
213810001807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810001808	Walker A/P-loop; other site
213810001809	ATP binding site [chemical binding]; other site
213810001810	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
213810001811	PLD-like domain; Region: PLDc_2; pfam13091
213810001812	putative active site [active]
213810001813	catalytic site [active]
213810001814	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
213810001815	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
213810001816	ATP binding site [chemical binding]; other site
213810001817	putative Mg++ binding site [ion binding]; other site
213810001818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
213810001819	nucleotide binding region [chemical binding]; other site
213810001820	ATP-binding site [chemical binding]; other site
213810001821	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
213810001822	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
213810001823	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
213810001824	Active Sites [active]
213810001825	WYL domain; Region: WYL; pfam13280
213810001826	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
213810001827	thymidine kinase; Provisional; Region: PRK04296
213810001828	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
213810001829	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
213810001830	ADP-ribose binding site [chemical binding]; other site
213810001831	TIR domain; Region: TIR_2; pfam13676
213810001832	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
213810001833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810001834	Coenzyme A binding pocket [chemical binding]; other site
213810001835	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
213810001836	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
213810001837	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
213810001838	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
213810001839	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
213810001840	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
213810001841	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
213810001842	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
213810001843	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
213810001844	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
213810001845	putative active site [active]
213810001846	putative metal binding site [ion binding]; other site
213810001847	Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548
213810001848	dockerin binding interface; other site
213810001849	Predicted permeases [General function prediction only]; Region: COG0679
213810001850	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
213810001851	active site
213810001852	oxyanion hole [active]
213810001853	catalytic triad [active]
213810001854	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
213810001855	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
213810001856	dimerization interface [polypeptide binding]; other site
213810001857	active site
213810001858	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
213810001859	L-aspartate oxidase; Provisional; Region: PRK06175
213810001860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810001861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810001862	dimer interface [polypeptide binding]; other site
213810001863	phosphorylation site [posttranslational modification]
213810001864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810001865	ATP binding site [chemical binding]; other site
213810001866	Mg2+ binding site [ion binding]; other site
213810001867	G-X-G motif; other site
213810001868	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810001869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810001870	active site
213810001871	phosphorylation site [posttranslational modification]
213810001872	intermolecular recognition site; other site
213810001873	dimerization interface [polypeptide binding]; other site
213810001874	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810001875	DNA binding site [nucleotide binding]
213810001876	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
213810001877	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810001878	putative active site [active]
213810001879	putative metal binding site [ion binding]; other site
213810001880	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
213810001881	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
213810001882	GDP-binding site [chemical binding]; other site
213810001883	ACT binding site; other site
213810001884	IMP binding site; other site
213810001885	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
213810001886	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
213810001887	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
213810001888	classical (c) SDRs; Region: SDR_c; cd05233
213810001889	NAD(P) binding site [chemical binding]; other site
213810001890	active site
213810001891	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810001892	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810001893	Walker A/P-loop; other site
213810001894	ATP binding site [chemical binding]; other site
213810001895	Q-loop/lid; other site
213810001896	ABC transporter signature motif; other site
213810001897	Walker B; other site
213810001898	D-loop; other site
213810001899	H-loop/switch region; other site
213810001900	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
213810001901	FtsX-like permease family; Region: FtsX; pfam02687
213810001902	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
213810001903	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
213810001904	FtsX-like permease family; Region: FtsX; pfam02687
213810001905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810001906	Coenzyme A binding pocket [chemical binding]; other site
213810001907	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
213810001908	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
213810001909	homodimer interface [polypeptide binding]; other site
213810001910	substrate-cofactor binding pocket; other site
213810001911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810001912	catalytic residue [active]
213810001913	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
213810001914	ATP synthase subunit C; Region: ATP-synt_C; cl00466
213810001915	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
213810001916	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
213810001917	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
213810001918	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
213810001919	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
213810001920	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
213810001921	beta subunit interaction interface [polypeptide binding]; other site
213810001922	Walker A motif; other site
213810001923	ATP binding site [chemical binding]; other site
213810001924	Walker B motif; other site
213810001925	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
213810001926	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
213810001927	core domain interface [polypeptide binding]; other site
213810001928	delta subunit interface [polypeptide binding]; other site
213810001929	epsilon subunit interface [polypeptide binding]; other site
213810001930	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
213810001931	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
213810001932	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
213810001933	alpha subunit interaction interface [polypeptide binding]; other site
213810001934	Walker A motif; other site
213810001935	ATP binding site [chemical binding]; other site
213810001936	Walker B motif; other site
213810001937	inhibitor binding site; inhibition site
213810001938	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
213810001939	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
213810001940	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
213810001941	gamma subunit interface [polypeptide binding]; other site
213810001942	epsilon subunit interface [polypeptide binding]; other site
213810001943	LBP interface [polypeptide binding]; other site
213810001944	Predicted membrane protein [Function unknown]; Region: COG2323
213810001945	MoxR-like ATPases [General function prediction only]; Region: COG0714
213810001946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810001947	Walker A motif; other site
213810001948	ATP binding site [chemical binding]; other site
213810001949	Walker B motif; other site
213810001950	arginine finger; other site
213810001951	Protein of unknown function DUF58; Region: DUF58; pfam01882
213810001952	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
213810001953	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
213810001954	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
213810001955	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
213810001956	Bacterial SH3 domain; Region: SH3_3; pfam08239
213810001957	Bacterial SH3 domain; Region: SH3_3; cl17532
213810001958	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
213810001959	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810001960	active site
213810001961	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
213810001962	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
213810001963	active site
213810001964	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
213810001965	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810001966	RNA binding surface [nucleotide binding]; other site
213810001967	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
213810001968	active site
213810001969	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
213810001970	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
213810001971	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
213810001972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810001973	Walker A/P-loop; other site
213810001974	ATP binding site [chemical binding]; other site
213810001975	Q-loop/lid; other site
213810001976	ABC transporter signature motif; other site
213810001977	Walker B; other site
213810001978	D-loop; other site
213810001979	H-loop/switch region; other site
213810001980	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
213810001981	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
213810001982	homodimer interface [polypeptide binding]; other site
213810001983	substrate-cofactor binding pocket; other site
213810001984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810001985	catalytic residue [active]
213810001986	Transcriptional regulator; Region: Rrf2; cl17282
213810001987	Rrf2 family protein; Region: rrf2_super; TIGR00738
213810001988	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
213810001989	homodimer interaction site [polypeptide binding]; other site
213810001990	cofactor binding site; other site
213810001991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810001992	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
213810001993	active site
213810001994	motif I; other site
213810001995	motif II; other site
213810001996	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
213810001997	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
213810001998	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
213810001999	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
213810002000	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
213810002001	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
213810002002	dimerization domain swap beta strand [polypeptide binding]; other site
213810002003	regulatory protein interface [polypeptide binding]; other site
213810002004	active site
213810002005	regulatory phosphorylation site [posttranslational modification]; other site
213810002006	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
213810002007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
213810002008	TPR repeat; Region: TPR_11; pfam13414
213810002009	binding surface
213810002010	TPR motif; other site
213810002011	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
213810002012	Peptidase family M23; Region: Peptidase_M23; pfam01551
213810002013	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
213810002014	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
213810002015	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
213810002016	Predicted membrane protein [Function unknown]; Region: COG4709
213810002017	Predicted transcriptional regulators [Transcription]; Region: COG1695
213810002018	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
213810002019	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
213810002020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
213810002021	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
213810002022	Stage III sporulation protein D; Region: SpoIIID; pfam12116
213810002023	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
213810002024	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
213810002025	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
213810002026	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
213810002027	active site
213810002028	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
213810002029	putative trimer interface [polypeptide binding]; other site
213810002030	putative CoA binding site [chemical binding]; other site
213810002031	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
213810002032	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
213810002033	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
213810002034	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
213810002035	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
213810002036	DHH family; Region: DHH; pfam01368
213810002037	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
213810002038	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
213810002039	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
213810002040	replicative DNA helicase; Region: DnaB; TIGR00665
213810002041	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
213810002042	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
213810002043	Walker A motif; other site
213810002044	ATP binding site [chemical binding]; other site
213810002045	Walker B motif; other site
213810002046	DNA binding loops [nucleotide binding]
213810002047	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
213810002048	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
213810002049	TilS substrate C-terminal domain; Region: TilS_C; smart00977
213810002050	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
213810002051	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810002052	Walker A/P-loop; other site
213810002053	ATP binding site [chemical binding]; other site
213810002054	Q-loop/lid; other site
213810002055	ABC transporter signature motif; other site
213810002056	Walker B; other site
213810002057	D-loop; other site
213810002058	H-loop/switch region; other site
213810002059	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
213810002060	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
213810002061	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
213810002062	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810002063	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810002064	ABC transporter; Region: ABC_tran_2; pfam12848
213810002065	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810002066	ABC transporter; Region: ABC_tran_2; pfam12848
213810002067	PAS fold; Region: PAS_3; pfam08447
213810002068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
213810002069	heme pocket [chemical binding]; other site
213810002070	PAS fold; Region: PAS_3; pfam08447
213810002071	putative active site [active]
213810002072	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
213810002073	Zn2+ binding site [ion binding]; other site
213810002074	Mg2+ binding site [ion binding]; other site
213810002075	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
213810002076	Sel1-like repeats; Region: SEL1; smart00671
213810002077	Protein of unknown function (DUF998); Region: DUF998; pfam06197
213810002078	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
213810002079	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810002080	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810002081	non-specific DNA binding site [nucleotide binding]; other site
213810002082	salt bridge; other site
213810002083	sequence-specific DNA binding site [nucleotide binding]; other site
213810002084	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
213810002085	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
213810002086	non-heme iron binding site [ion binding]; other site
213810002087	Methyltransferase domain; Region: Methyltransf_31; pfam13847
213810002088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810002089	S-adenosylmethionine binding site [chemical binding]; other site
213810002090	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810002091	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810002092	Walker A/P-loop; other site
213810002093	ATP binding site [chemical binding]; other site
213810002094	Q-loop/lid; other site
213810002095	ABC transporter signature motif; other site
213810002096	Walker B; other site
213810002097	D-loop; other site
213810002098	H-loop/switch region; other site
213810002099	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
213810002100	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810002101	Walker A/P-loop; other site
213810002102	ATP binding site [chemical binding]; other site
213810002103	Q-loop/lid; other site
213810002104	ABC transporter signature motif; other site
213810002105	Walker B; other site
213810002106	D-loop; other site
213810002107	H-loop/switch region; other site
213810002108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
213810002109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
213810002110	WHG domain; Region: WHG; pfam13305
213810002111	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
213810002112	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
213810002113	active site
213810002114	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
213810002115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810002116	active site
213810002117	DEAD-like helicases superfamily; Region: DEXDc; smart00487
213810002118	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
213810002119	Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443
213810002120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810002121	AAA domain; Region: AAA_21; pfam13304
213810002122	Walker A/P-loop; other site
213810002123	ATP binding site [chemical binding]; other site
213810002124	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
213810002125	putative active site [active]
213810002126	putative metal-binding site [ion binding]; other site
213810002127	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
213810002128	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810002129	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
213810002130	putative catalytic residues [active]
213810002131	catalytic nucleophile [active]
213810002132	Recombinase; Region: Recombinase; pfam07508
213810002133	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
213810002134	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
213810002135	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
213810002136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810002137	FeS/SAM binding site; other site
213810002138	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
213810002139	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
213810002140	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
213810002141	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
213810002142	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
213810002143	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
213810002144	DNA-binding site [nucleotide binding]; DNA binding site
213810002145	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
213810002146	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810002147	catalytic residue [active]
213810002148	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
213810002149	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
213810002150	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
213810002151	DNA binding site [nucleotide binding]
213810002152	active site
213810002153	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
213810002154	endonuclease III; Region: ENDO3c; smart00478
213810002155	minor groove reading motif; other site
213810002156	helix-hairpin-helix signature motif; other site
213810002157	substrate binding pocket [chemical binding]; other site
213810002158	active site
213810002159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
213810002160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
213810002161	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
213810002162	dimerization interface [polypeptide binding]; other site
213810002163	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
213810002164	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
213810002165	dimer interface [polypeptide binding]; other site
213810002166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810002167	catalytic residue [active]
213810002168	hypothetical protein; Provisional; Region: PRK11820
213810002169	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
213810002170	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
213810002171	hypothetical protein; Provisional; Region: PRK04323
213810002172	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
213810002173	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
213810002174	catalytic site [active]
213810002175	G-X2-G-X-G-K; other site
213810002176	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
213810002177	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
213810002178	active site
213810002179	catalytic residues [active]
213810002180	metal binding site [ion binding]; metal-binding site
213810002181	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
213810002182	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
213810002183	putative active site [active]
213810002184	substrate binding site [chemical binding]; other site
213810002185	putative cosubstrate binding site; other site
213810002186	catalytic site [active]
213810002187	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
213810002188	substrate binding site [chemical binding]; other site
213810002189	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
213810002190	NusB family; Region: NusB; pfam01029
213810002191	16S rRNA methyltransferase B; Provisional; Region: PRK14902
213810002192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810002193	S-adenosylmethionine binding site [chemical binding]; other site
213810002194	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
213810002195	active site
213810002196	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
213810002197	Catalytic domain of Protein Kinases; Region: PKc; cd00180
213810002198	active site
213810002199	ATP binding site [chemical binding]; other site
213810002200	substrate binding site [chemical binding]; other site
213810002201	activation loop (A-loop); other site
213810002202	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
213810002203	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
213810002204	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
213810002205	GTPase RsgA; Reviewed; Region: PRK00098
213810002206	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
213810002207	RNA binding site [nucleotide binding]; other site
213810002208	homodimer interface [polypeptide binding]; other site
213810002209	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
213810002210	GTPase/Zn-binding domain interface [polypeptide binding]; other site
213810002211	GTP/Mg2+ binding site [chemical binding]; other site
213810002212	G4 box; other site
213810002213	G5 box; other site
213810002214	G1 box; other site
213810002215	Switch I region; other site
213810002216	G2 box; other site
213810002217	G3 box; other site
213810002218	Switch II region; other site
213810002219	Thiamine pyrophosphokinase; Region: TPK; cd07995
213810002220	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
213810002221	active site
213810002222	dimerization interface [polypeptide binding]; other site
213810002223	thiamine binding site [chemical binding]; other site
213810002224	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
213810002225	putative substrate binding region [chemical binding]; other site
213810002226	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
213810002227	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
213810002228	B12 binding site [chemical binding]; other site
213810002229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810002230	FeS/SAM binding site; other site
213810002231	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
213810002232	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
213810002233	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
213810002234	Catalytic site [active]
213810002235	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
213810002236	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
213810002237	Catalytic site [active]
213810002238	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
213810002239	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
213810002240	GTP/Mg2+ binding site [chemical binding]; other site
213810002241	G4 box; other site
213810002242	G5 box; other site
213810002243	G1 box; other site
213810002244	Switch I region; other site
213810002245	G2 box; other site
213810002246	G3 box; other site
213810002247	Switch II region; other site
213810002248	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
213810002249	RNA/DNA hybrid binding site [nucleotide binding]; other site
213810002250	active site
213810002251	hypothetical protein; Reviewed; Region: PRK12497
213810002252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
213810002253	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810002254	active site
213810002255	metal binding site [ion binding]; metal-binding site
213810002256	trigger factor; Provisional; Region: tig; PRK01490
213810002257	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
213810002258	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
213810002259	Clp protease; Region: CLP_protease; pfam00574
213810002260	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
213810002261	oligomer interface [polypeptide binding]; other site
213810002262	active site residues [active]
213810002263	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
213810002264	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
213810002265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810002266	Walker A motif; other site
213810002267	ATP binding site [chemical binding]; other site
213810002268	Walker B motif; other site
213810002269	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
213810002270	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
213810002271	Found in ATP-dependent protease La (LON); Region: LON; smart00464
213810002272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810002273	Walker A motif; other site
213810002274	ATP binding site [chemical binding]; other site
213810002275	Walker B motif; other site
213810002276	arginine finger; other site
213810002277	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
213810002278	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
213810002279	G1 box; other site
213810002280	GTP/Mg2+ binding site [chemical binding]; other site
213810002281	Switch I region; other site
213810002282	G2 box; other site
213810002283	G3 box; other site
213810002284	Switch II region; other site
213810002285	G4 box; other site
213810002286	G5 box; other site
213810002287	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
213810002288	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
213810002289	minor groove reading motif; other site
213810002290	helix-hairpin-helix signature motif; other site
213810002291	substrate binding pocket [chemical binding]; other site
213810002292	active site
213810002293	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
213810002294	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
213810002295	DEAD/DEAH box helicase; Region: DEAD; pfam00270
213810002296	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
213810002297	SEC-C motif; Region: SEC-C; pfam02810
213810002298	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
213810002299	dimerization interface [polypeptide binding]; other site
213810002300	putative active cleft [active]
213810002301	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
213810002302	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
213810002303	Interdomain contacts; other site
213810002304	Cytokine receptor motif; other site
213810002305	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
213810002306	Interdomain contacts; other site
213810002307	Cytokine receptor motif; other site
213810002308	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
213810002309	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002310	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002311	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002312	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002313	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002314	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002315	Leucine rich repeat; Region: LRR_8; pfam13855
213810002316	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002317	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002318	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002319	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002320	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
213810002321	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
213810002322	coproporphyrinogen III oxidase; Validated; Region: PRK05628
213810002323	HemN C-terminal domain; Region: HemN_C; pfam06969
213810002324	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
213810002325	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
213810002326	active site
213810002327	HIGH motif; other site
213810002328	dimer interface [polypeptide binding]; other site
213810002329	KMSKS motif; other site
213810002330	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810002331	RNA binding surface [nucleotide binding]; other site
213810002332	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
213810002333	putative trimer interface [polypeptide binding]; other site
213810002334	putative CoA binding site [chemical binding]; other site
213810002335	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
213810002336	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
213810002337	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
213810002338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810002339	FeS/SAM binding site; other site
213810002340	TRAM domain; Region: TRAM; cl01282
213810002341	Protein of unknown function (DUF964); Region: DUF964; pfam06133
213810002342	MutS domain II; Region: MutS_II; pfam05188
213810002343	MutS domain III; Region: MutS_III; pfam05192
213810002344	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
213810002345	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
213810002346	Walker A/P-loop; other site
213810002347	ATP binding site [chemical binding]; other site
213810002348	Q-loop/lid; other site
213810002349	ABC transporter signature motif; other site
213810002350	Walker B; other site
213810002351	D-loop; other site
213810002352	H-loop/switch region; other site
213810002353	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
213810002354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810002355	ATP binding site [chemical binding]; other site
213810002356	Mg2+ binding site [ion binding]; other site
213810002357	G-X-G motif; other site
213810002358	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
213810002359	ATP binding site [chemical binding]; other site
213810002360	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
213810002361	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
213810002362	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
213810002363	bacterial Hfq-like; Region: Hfq; cd01716
213810002364	hexamer interface [polypeptide binding]; other site
213810002365	Sm1 motif; other site
213810002366	RNA binding site [nucleotide binding]; other site
213810002367	Sm2 motif; other site
213810002368	HlyD family secretion protein; Region: HlyD_2; pfam12700
213810002369	putative membrane fusion protein; Region: TIGR02828
213810002370	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
213810002371	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
213810002372	catalytic residue [active]
213810002373	Protein of unknown function (DUF552); Region: DUF552; cl00775
213810002374	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
213810002375	DivIVA protein; Region: DivIVA; pfam05103
213810002376	DivIVA domain; Region: DivI1A_domain; TIGR03544
213810002377	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
213810002378	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
213810002379	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810002380	active site
213810002381	HIGH motif; other site
213810002382	nucleotide binding site [chemical binding]; other site
213810002383	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
213810002384	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
213810002385	active site
213810002386	KMSKS motif; other site
213810002387	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
213810002388	tRNA binding surface [nucleotide binding]; other site
213810002389	anticodon binding site; other site
213810002390	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
213810002391	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
213810002392	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
213810002393	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810002394	RNA binding surface [nucleotide binding]; other site
213810002395	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
213810002396	active site
213810002397	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
213810002398	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
213810002399	motif II; other site
213810002400	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
213810002401	transketolase; Reviewed; Region: PRK05899
213810002402	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
213810002403	TPP-binding site [chemical binding]; other site
213810002404	dimer interface [polypeptide binding]; other site
213810002405	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
213810002406	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
213810002407	PYR/PP interface [polypeptide binding]; other site
213810002408	dimer interface [polypeptide binding]; other site
213810002409	TPP binding site [chemical binding]; other site
213810002410	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
213810002411	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
213810002412	active site
213810002413	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
213810002414	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
213810002415	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
213810002416	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
213810002417	glutamine binding [chemical binding]; other site
213810002418	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
213810002419	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
213810002420	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
213810002421	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
213810002422	active site
213810002423	ribulose/triose binding site [chemical binding]; other site
213810002424	phosphate binding site [ion binding]; other site
213810002425	substrate (anthranilate) binding pocket [chemical binding]; other site
213810002426	product (indole) binding pocket [chemical binding]; other site
213810002427	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
213810002428	active site
213810002429	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
213810002430	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
213810002431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810002432	catalytic residue [active]
213810002433	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
213810002434	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
213810002435	substrate binding site [chemical binding]; other site
213810002436	active site
213810002437	catalytic residues [active]
213810002438	heterodimer interface [polypeptide binding]; other site
213810002439	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
213810002440	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
213810002441	active site
213810002442	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
213810002443	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
213810002444	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
213810002445	DXD motif; other site
213810002446	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
213810002447	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810002448	Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160
213810002449	putative homodimer interface [polypeptide binding]; other site
213810002450	putative homotetramer interface [polypeptide binding]; other site
213810002451	putative metal binding site [ion binding]; other site
213810002452	putative homodimer-homodimer interface [polypeptide binding]; other site
213810002453	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
213810002454	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810002455	Soluble P-type ATPase [General function prediction only]; Region: COG4087
213810002456	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
213810002457	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810002458	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810002459	Walker A/P-loop; other site
213810002460	ATP binding site [chemical binding]; other site
213810002461	Q-loop/lid; other site
213810002462	ABC transporter signature motif; other site
213810002463	Walker B; other site
213810002464	D-loop; other site
213810002465	H-loop/switch region; other site
213810002466	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
213810002467	substrate binding site [chemical binding]; other site
213810002468	active site
213810002469	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
213810002470	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
213810002471	catalytic triad [active]
213810002472	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
213810002473	active site
213810002474	Dockerin type I repeat; Region: Dockerin_1; pfam00404
213810002475	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810002476	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810002477	Transcriptional regulators [Transcription]; Region: PurR; COG1609
213810002478	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810002479	ligand binding site [chemical binding]; other site
213810002480	dimerization interface [polypeptide binding]; other site
213810002481	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810002482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810002483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810002484	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
213810002485	Walker A/P-loop; other site
213810002486	ATP binding site [chemical binding]; other site
213810002487	Q-loop/lid; other site
213810002488	ABC transporter signature motif; other site
213810002489	Walker B; other site
213810002490	D-loop; other site
213810002491	H-loop/switch region; other site
213810002492	aconitate hydratase; Provisional; Region: acnA; PRK12881
213810002493	LabA_like proteins; Region: LabA_like/DUF88; cl10034
213810002494	putative metal binding site [ion binding]; other site
213810002495	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
213810002496	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
213810002497	inhibitor-cofactor binding pocket; inhibition site
213810002498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810002499	catalytic residue [active]
213810002500	Bacterial sugar transferase; Region: Bac_transf; pfam02397
213810002501	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
213810002502	active site
213810002503	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
213810002504	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
213810002505	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
213810002506	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
213810002507	NAD(P) binding site [chemical binding]; other site
213810002508	homodimer interface [polypeptide binding]; other site
213810002509	substrate binding site [chemical binding]; other site
213810002510	active site
213810002511	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
213810002512	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
213810002513	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
213810002514	D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662
213810002515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
213810002516	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
213810002517	putative ADP-binding pocket [chemical binding]; other site
213810002518	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
213810002519	O-Antigen ligase; Region: Wzy_C; pfam04932
213810002520	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
213810002521	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
213810002522	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
213810002523	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
213810002524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
213810002525	NAD(P) binding site [chemical binding]; other site
213810002526	active site
213810002527	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
213810002528	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
213810002529	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
213810002530	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
213810002531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
213810002532	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
213810002533	NAD(P) binding site [chemical binding]; other site
213810002534	active site
213810002535	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
213810002536	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810002537	CAAX protease self-immunity; Region: Abi; pfam02517
213810002538	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
213810002539	nucleoside/Zn binding site; other site
213810002540	dimer interface [polypeptide binding]; other site
213810002541	catalytic motif [active]
213810002542	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
213810002543	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
213810002544	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
213810002545	mRNA/rRNA interface [nucleotide binding]; other site
213810002546	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
213810002547	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
213810002548	23S rRNA interface [nucleotide binding]; other site
213810002549	L7/L12 interface [polypeptide binding]; other site
213810002550	putative thiostrepton binding site; other site
213810002551	L25 interface [polypeptide binding]; other site
213810002552	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
213810002553	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
213810002554	putative homodimer interface [polypeptide binding]; other site
213810002555	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
213810002556	heterodimer interface [polypeptide binding]; other site
213810002557	homodimer interface [polypeptide binding]; other site
213810002558	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
213810002559	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
213810002560	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
213810002561	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
213810002562	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
213810002563	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
213810002564	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
213810002565	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
213810002566	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
213810002567	active site
213810002568	HIGH motif; other site
213810002569	KMSK motif region; other site
213810002570	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
213810002571	tRNA binding surface [nucleotide binding]; other site
213810002572	anticodon binding site; other site
213810002573	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
213810002574	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
213810002575	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
213810002576	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
213810002577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
213810002578	Peptidase family M23; Region: Peptidase_M23; pfam01551
213810002579	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
213810002580	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
213810002581	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
213810002582	protein binding site [polypeptide binding]; other site
213810002583	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
213810002584	Catalytic dyad [active]
213810002585	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
213810002586	active site
213810002587	metal binding site [ion binding]; metal-binding site
213810002588	homotetramer interface [polypeptide binding]; other site
213810002589	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
213810002590	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
213810002591	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
213810002592	dimer interface [polypeptide binding]; other site
213810002593	ADP-ribose binding site [chemical binding]; other site
213810002594	active site
213810002595	nudix motif; other site
213810002596	metal binding site [ion binding]; metal-binding site
213810002597	SpoVG; Region: SpoVG; pfam04026
213810002598	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
213810002599	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
213810002600	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
213810002601	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
213810002602	LexA repressor; Validated; Region: PRK00215
213810002603	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
213810002604	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810002605	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810002606	non-specific DNA binding site [nucleotide binding]; other site
213810002607	salt bridge; other site
213810002608	sequence-specific DNA binding site [nucleotide binding]; other site
213810002609	Cupin domain; Region: Cupin_2; pfam07883
213810002610	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810002611	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
213810002612	acyl-activating enzyme (AAE) consensus motif; other site
213810002613	AMP binding site [chemical binding]; other site
213810002614	active site
213810002615	CoA binding site [chemical binding]; other site
213810002616	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
213810002617	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
213810002618	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
213810002619	intersubunit interface [polypeptide binding]; other site
213810002620	active site
213810002621	zinc binding site [ion binding]; other site
213810002622	Na+ binding site [ion binding]; other site
213810002623	Repair protein; Region: Repair_PSII; pfam04536
213810002624	Repair protein; Region: Repair_PSII; cl01535
213810002625	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
213810002626	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810002627	Walker A/P-loop; other site
213810002628	ATP binding site [chemical binding]; other site
213810002629	Q-loop/lid; other site
213810002630	ABC transporter signature motif; other site
213810002631	Walker B; other site
213810002632	D-loop; other site
213810002633	H-loop/switch region; other site
213810002634	Predicted transcriptional regulators [Transcription]; Region: COG1725
213810002635	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
213810002636	DNA-binding site [nucleotide binding]; DNA binding site
213810002637	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
213810002638	active site
213810002639	catalytic triad [active]
213810002640	oxyanion hole [active]
213810002641	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
213810002642	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
213810002643	TrkA-N domain; Region: TrkA_N; pfam02254
213810002644	TrkA-C domain; Region: TrkA_C; pfam02080
213810002645	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
213810002646	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
213810002647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810002648	homodimer interface [polypeptide binding]; other site
213810002649	catalytic residue [active]
213810002650	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
213810002651	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
213810002652	homodimer interface [polypeptide binding]; other site
213810002653	metal binding site [ion binding]; metal-binding site
213810002654	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
213810002655	homodimer interface [polypeptide binding]; other site
213810002656	active site
213810002657	putative chemical substrate binding site [chemical binding]; other site
213810002658	metal binding site [ion binding]; metal-binding site
213810002659	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
213810002660	IHF dimer interface [polypeptide binding]; other site
213810002661	IHF - DNA interface [nucleotide binding]; other site
213810002662	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810002663	RNA binding surface [nucleotide binding]; other site
213810002664	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
213810002665	beta-galactosidase; Region: BGL; TIGR03356
213810002666	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
213810002667	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
213810002668	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
213810002669	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
213810002670	excinuclease ABC subunit B; Provisional; Region: PRK05298
213810002671	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
213810002672	ATP binding site [chemical binding]; other site
213810002673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
213810002674	nucleotide binding region [chemical binding]; other site
213810002675	ATP-binding site [chemical binding]; other site
213810002676	Ultra-violet resistance protein B; Region: UvrB; pfam12344
213810002677	UvrB/uvrC motif; Region: UVR; pfam02151
213810002678	hypothetical protein; Reviewed; Region: PRK00024
213810002679	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
213810002680	MPN+ (JAMM) motif; other site
213810002681	Zinc-binding site [ion binding]; other site
213810002682	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
213810002683	Chain length determinant protein; Region: Wzz; cl15801
213810002684	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
213810002685	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
213810002686	PHP domain; Region: PHP; pfam02811
213810002687	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
213810002688	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
213810002689	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
213810002690	glutaminase active site [active]
213810002691	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
213810002692	dimer interface [polypeptide binding]; other site
213810002693	active site
213810002694	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
213810002695	dimer interface [polypeptide binding]; other site
213810002696	active site
213810002697	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
213810002698	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
213810002699	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810002700	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
213810002701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810002702	motif II; other site
213810002703	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
213810002704	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
213810002705	Part of AAA domain; Region: AAA_19; pfam13245
213810002706	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
213810002707	AAA domain; Region: AAA_12; pfam13087
213810002708	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
213810002709	SUKH-4 immunity protein; Region: SUKH-4; pfam14435
213810002710	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810002711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810002712	non-specific DNA binding site [nucleotide binding]; other site
213810002713	salt bridge; other site
213810002714	sequence-specific DNA binding site [nucleotide binding]; other site
213810002715	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
213810002716	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810002717	Int/Topo IB signature motif; other site
213810002718	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
213810002719	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
213810002720	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
213810002721	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
213810002722	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
213810002723	DNA methylase; Region: N6_N4_Mtase; pfam01555
213810002724	DNA methylase; Region: N6_N4_Mtase; cl17433
213810002725	Josephin; Region: Josephin; pfam02099
213810002726	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
213810002727	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
213810002728	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
213810002729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
213810002730	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
213810002731	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
213810002732	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
213810002733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810002734	DNA binding residues [nucleotide binding]
213810002735	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
213810002736	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
213810002737	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002738	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002739	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002740	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002741	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002742	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002743	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002744	putative transposase OrfB; Reviewed; Region: PHA02517
213810002745	Integrase core domain; Region: rve; pfam00665
213810002746	Integrase core domain; Region: rve_3; cl15866
213810002747	WYL domain; Region: WYL; pfam13280
213810002748	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002749	Lamin Tail Domain; Region: LTD; pfam00932
213810002750	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
213810002751	CotH protein; Region: CotH; pfam08757
213810002752	Acyltransferase family; Region: Acyl_transf_3; pfam01757
213810002753	D-mannose binding lectin; Region: B_lectin; pfam01453
213810002754	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
213810002755	mannose binding site [chemical binding]; other site
213810002756	dimerization interface [polypeptide binding]; other site
213810002757	D-mannose binding lectin; Region: B_lectin; pfam01453
213810002758	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
213810002759	mannose binding site [chemical binding]; other site
213810002760	dimerization interface [polypeptide binding]; other site
213810002761	D-mannose binding lectin; Region: B_lectin; pfam01453
213810002762	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
213810002763	mannose binding site [chemical binding]; other site
213810002764	dimerization interface [polypeptide binding]; other site
213810002765	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
213810002766	metal ion-dependent adhesion site (MIDAS); other site
213810002767	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
213810002768	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
213810002769	active site
213810002770	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810002771	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
213810002772	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810002773	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810002774	Walker A/P-loop; other site
213810002775	ATP binding site [chemical binding]; other site
213810002776	Q-loop/lid; other site
213810002777	ABC transporter signature motif; other site
213810002778	Walker B; other site
213810002779	D-loop; other site
213810002780	H-loop/switch region; other site
213810002781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
213810002782	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
213810002783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810002784	active site
213810002785	phosphorylation site [posttranslational modification]
213810002786	intermolecular recognition site; other site
213810002787	dimerization interface [polypeptide binding]; other site
213810002788	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
213810002789	DNA binding residues [nucleotide binding]
213810002790	dimerization interface [polypeptide binding]; other site
213810002791	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
213810002792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
213810002793	active site
213810002794	phosphorylation site [posttranslational modification]
213810002795	intermolecular recognition site; other site
213810002796	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
213810002797	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
213810002798	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
213810002799	putative dimer interface [polypeptide binding]; other site
213810002800	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
213810002801	MarR family; Region: MarR; pfam01047
213810002802	Predicted membrane protein [Function unknown]; Region: COG2364
213810002803	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
213810002804	alpha-galactosidase; Region: PLN02808; cl17638
213810002805	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
213810002806	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
213810002807	NAD(P) binding site [chemical binding]; other site
213810002808	LDH/MDH dimer interface [polypeptide binding]; other site
213810002809	substrate binding site [chemical binding]; other site
213810002810	fumarate hydratase; Reviewed; Region: fumC; PRK00485
213810002811	Class II fumarases; Region: Fumarase_classII; cd01362
213810002812	active site
213810002813	tetramer interface [polypeptide binding]; other site
213810002814	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
213810002815	Cysteine-rich domain; Region: CCG; pfam02754
213810002816	Cysteine-rich domain; Region: CCG; pfam02754
213810002817	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
213810002818	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
213810002819	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
213810002820	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
213810002821	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
213810002822	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
213810002823	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810002824	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810002825	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
213810002826	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
213810002827	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
213810002828	FAD binding pocket [chemical binding]; other site
213810002829	FAD binding motif [chemical binding]; other site
213810002830	phosphate binding motif [ion binding]; other site
213810002831	beta-alpha-beta structure motif; other site
213810002832	NAD binding pocket [chemical binding]; other site
213810002833	Iron coordination center [ion binding]; other site
213810002834	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
213810002835	catalytic loop [active]
213810002836	iron binding site [ion binding]; other site
213810002837	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810002838	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
213810002839	L-aspartate oxidase; Provisional; Region: PRK06175
213810002840	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
213810002841	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
213810002842	4Fe-4S binding domain; Region: Fer4; pfam00037
213810002843	4Fe-4S binding domain; Region: Fer4; pfam00037
213810002844	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
213810002845	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
213810002846	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
213810002847	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
213810002848	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
213810002849	Domain of unknown function DUF21; Region: DUF21; pfam01595
213810002850	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
213810002851	Transporter associated domain; Region: CorC_HlyC; pfam03471
213810002852	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
213810002853	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
213810002854	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
213810002855	hypothetical protein; Provisional; Region: PRK06851
213810002856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
213810002857	Walker A motif; other site
213810002858	ATP binding site [chemical binding]; other site
213810002859	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
213810002860	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
213810002861	putative active site [active]
213810002862	dimerization interface [polypeptide binding]; other site
213810002863	putative tRNAtyr binding site [nucleotide binding]; other site
213810002864	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
213810002865	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
213810002866	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
213810002867	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
213810002868	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
213810002869	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
213810002870	motif 1; other site
213810002871	active site
213810002872	motif 2; other site
213810002873	motif 3; other site
213810002874	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
213810002875	DHHA1 domain; Region: DHHA1; pfam02272
213810002876	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
213810002877	nucleotide binding site/active site [active]
213810002878	HIT family signature motif; other site
213810002879	catalytic residue [active]
213810002880	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810002881	active site
213810002882	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
213810002883	DNA polymerase III, delta subunit; Region: holA; TIGR01128
213810002884	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
213810002885	active site
213810002886	metal binding site [ion binding]; metal-binding site
213810002887	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
213810002888	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
213810002889	DHHW protein; Region: DHHW; pfam14286
213810002890	DHHW protein; Region: DHHW; pfam14286
213810002891	xylose isomerase; Provisional; Region: PRK05474
213810002892	xylose isomerase; Region: xylose_isom_A; TIGR02630
213810002893	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
213810002894	N- and C-terminal domain interface [polypeptide binding]; other site
213810002895	D-xylulose kinase; Region: XylB; TIGR01312
213810002896	active site
213810002897	MgATP binding site [chemical binding]; other site
213810002898	catalytic site [active]
213810002899	metal binding site [ion binding]; metal-binding site
213810002900	xylulose binding site [chemical binding]; other site
213810002901	homodimer interface [polypeptide binding]; other site
213810002902	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
213810002903	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
213810002904	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
213810002905	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
213810002906	RNA binding site [nucleotide binding]; other site
213810002907	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
213810002908	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
213810002909	active site
213810002910	metal binding site [ion binding]; metal-binding site
213810002911	DNA repair protein RadA; Provisional; Region: PRK11823
213810002912	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
213810002913	Walker A motif; other site
213810002914	ATP binding site [chemical binding]; other site
213810002915	Walker B motif; other site
213810002916	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
213810002917	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
213810002918	Clp amino terminal domain; Region: Clp_N; pfam02861
213810002919	Clp amino terminal domain; Region: Clp_N; pfam02861
213810002920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810002921	Walker A motif; other site
213810002922	ATP binding site [chemical binding]; other site
213810002923	Walker B motif; other site
213810002924	arginine finger; other site
213810002925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810002926	Walker A motif; other site
213810002927	ATP binding site [chemical binding]; other site
213810002928	Walker B motif; other site
213810002929	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
213810002930	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
213810002931	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
213810002932	active site
213810002933	NAD binding site [chemical binding]; other site
213810002934	metal binding site [ion binding]; metal-binding site
213810002935	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
213810002936	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
213810002937	active site
213810002938	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
213810002939	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
213810002940	PYR/PP interface [polypeptide binding]; other site
213810002941	dimer interface [polypeptide binding]; other site
213810002942	TPP binding site [chemical binding]; other site
213810002943	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
213810002944	TPP-binding site; other site
213810002945	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
213810002946	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
213810002947	tetramer interface [polypeptide binding]; other site
213810002948	active site
213810002949	Mg2+/Mn2+ binding site [ion binding]; other site
213810002950	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
213810002951	B12 binding domain; Region: B12-binding; pfam02310
213810002952	B12 binding site [chemical binding]; other site
213810002953	Radical SAM superfamily; Region: Radical_SAM; pfam04055
213810002954	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
213810002955	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810002956	acyl-activating enzyme (AAE) consensus motif; other site
213810002957	AMP binding site [chemical binding]; other site
213810002958	active site
213810002959	CoA binding site [chemical binding]; other site
213810002960	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
213810002961	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
213810002962	putative acyl-acceptor binding pocket; other site
213810002963	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810002964	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
213810002965	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
213810002966	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
213810002967	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
213810002968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810002969	dimer interface [polypeptide binding]; other site
213810002970	conserved gate region; other site
213810002971	putative PBP binding loops; other site
213810002972	ABC-ATPase subunit interface; other site
213810002973	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
213810002974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810002975	dimer interface [polypeptide binding]; other site
213810002976	conserved gate region; other site
213810002977	putative PBP binding loops; other site
213810002978	ABC-ATPase subunit interface; other site
213810002979	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
213810002980	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
213810002981	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
213810002982	active site
213810002983	catalytic site [active]
213810002984	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
213810002985	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
213810002986	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
213810002987	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
213810002988	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810002989	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810002990	Walker A/P-loop; other site
213810002991	ATP binding site [chemical binding]; other site
213810002992	Q-loop/lid; other site
213810002993	ABC transporter signature motif; other site
213810002994	Walker B; other site
213810002995	D-loop; other site
213810002996	H-loop/switch region; other site
213810002997	FtsX-like permease family; Region: FtsX; pfam02687
213810002998	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
213810002999	FtsX-like permease family; Region: FtsX; pfam02687
213810003000	prephenate dehydrogenase; Validated; Region: PRK08507
213810003001	Prephenate dehydrogenase; Region: PDH; pfam02153
213810003002	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
213810003003	dimer interface [polypeptide binding]; other site
213810003004	Citrate synthase; Region: Citrate_synt; pfam00285
213810003005	active site
213810003006	citrylCoA binding site [chemical binding]; other site
213810003007	oxalacetate/citrate binding site [chemical binding]; other site
213810003008	coenzyme A binding site [chemical binding]; other site
213810003009	catalytic triad [active]
213810003010	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
213810003011	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
213810003012	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
213810003013	Walker A/P-loop; other site
213810003014	ATP binding site [chemical binding]; other site
213810003015	Q-loop/lid; other site
213810003016	ABC transporter signature motif; other site
213810003017	Walker B; other site
213810003018	D-loop; other site
213810003019	H-loop/switch region; other site
213810003020	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
213810003021	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
213810003022	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
213810003023	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
213810003024	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
213810003025	Amb_all domain; Region: Amb_all; smart00656
213810003026	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
213810003027	SmpB-tmRNA interface; other site
213810003028	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
213810003029	putative active site [active]
213810003030	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
213810003031	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810003032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810003033	Walker A/P-loop; other site
213810003034	ATP binding site [chemical binding]; other site
213810003035	Q-loop/lid; other site
213810003036	ABC transporter signature motif; other site
213810003037	Walker B; other site
213810003038	D-loop; other site
213810003039	H-loop/switch region; other site
213810003040	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
213810003041	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
213810003042	HlyD family secretion protein; Region: HlyD_3; pfam13437
213810003043	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
213810003044	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
213810003045	substrate binding site [chemical binding]; other site
213810003046	ATP binding site [chemical binding]; other site
213810003047	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
213810003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810003049	Walker A motif; other site
213810003050	ATP binding site [chemical binding]; other site
213810003051	Walker B motif; other site
213810003052	arginine finger; other site
213810003053	Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553
213810003054	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
213810003055	non-specific DNA binding site [nucleotide binding]; other site
213810003056	salt bridge; other site
213810003057	sequence-specific DNA binding site [nucleotide binding]; other site
213810003058	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810003059	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
213810003060	cofactor binding site; other site
213810003061	DNA binding site [nucleotide binding]
213810003062	substrate interaction site [chemical binding]; other site
213810003063	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
213810003064	seryl-tRNA synthetase; Provisional; Region: PRK05431
213810003065	integrase; Provisional; Region: int; PHA02601
213810003066	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810003067	Int/Topo IB signature motif; other site
213810003068	MarR family; Region: MarR_2; cl17246
213810003069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003070	non-specific DNA binding site [nucleotide binding]; other site
213810003071	salt bridge; other site
213810003072	sequence-specific DNA binding site [nucleotide binding]; other site
213810003073	GMP synthase; Reviewed; Region: guaA; PRK00074
213810003074	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
213810003075	AMP/PPi binding site [chemical binding]; other site
213810003076	candidate oxyanion hole; other site
213810003077	catalytic triad [active]
213810003078	potential glutamine specificity residues [chemical binding]; other site
213810003079	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
213810003080	ATP Binding subdomain [chemical binding]; other site
213810003081	Ligand Binding sites [chemical binding]; other site
213810003082	Dimerization subdomain; other site
213810003083	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
213810003084	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
213810003085	putative ATP binding site [chemical binding]; other site
213810003086	putative substrate interface [chemical binding]; other site
213810003087	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
213810003088	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
213810003089	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
213810003090	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
213810003091	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
213810003092	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
213810003093	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
213810003094	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
213810003095	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
213810003096	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
213810003097	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
213810003098	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
213810003099	RPB10 interaction site [polypeptide binding]; other site
213810003100	RPB1 interaction site [polypeptide binding]; other site
213810003101	RPB11 interaction site [polypeptide binding]; other site
213810003102	RPB3 interaction site [polypeptide binding]; other site
213810003103	RPB12 interaction site [polypeptide binding]; other site
213810003104	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003105	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003106	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
213810003107	S17 interaction site [polypeptide binding]; other site
213810003108	S8 interaction site; other site
213810003109	16S rRNA interaction site [nucleotide binding]; other site
213810003110	streptomycin interaction site [chemical binding]; other site
213810003111	23S rRNA interaction site [nucleotide binding]; other site
213810003112	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
213810003113	30S ribosomal protein S7; Validated; Region: PRK05302
213810003114	elongation factor G; Reviewed; Region: PRK00007
213810003115	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
213810003116	G1 box; other site
213810003117	putative GEF interaction site [polypeptide binding]; other site
213810003118	GTP/Mg2+ binding site [chemical binding]; other site
213810003119	Switch I region; other site
213810003120	G2 box; other site
213810003121	G3 box; other site
213810003122	Switch II region; other site
213810003123	G4 box; other site
213810003124	G5 box; other site
213810003125	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
213810003126	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
213810003127	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
213810003128	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
213810003129	Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446
213810003130	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713
213810003131	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810003132	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
213810003133	peptide chain release factor 2; Validated; Region: prfB; PRK00578
213810003134	This domain is found in peptide chain release factors; Region: PCRF; smart00937
213810003135	RF-1 domain; Region: RF-1; pfam00472
213810003136	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
213810003137	flavoprotein, HI0933 family; Region: TIGR00275
213810003138	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
213810003139	active site
213810003140	catalytic triad [active]
213810003141	oxyanion hole [active]
213810003142	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
213810003143	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
213810003144	phosphopeptide binding site; other site
213810003145	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
213810003146	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
213810003147	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
213810003148	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810003149	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
213810003150	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810003151	ligand binding site [chemical binding]; other site
213810003152	dimerization interface [polypeptide binding]; other site
213810003153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810003154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810003155	metal binding site [ion binding]; metal-binding site
213810003156	active site
213810003157	I-site; other site
213810003158	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
213810003159	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
213810003160	Domain of unknown function DUF87; Region: DUF87; pfam01935
213810003161	AAA-like domain; Region: AAA_10; pfam12846
213810003162	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
213810003163	active site
213810003164	catalytic site [active]
213810003165	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
213810003166	CHAP domain; Region: CHAP; cl17642
213810003167	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
213810003168	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810003169	DNA binding residues [nucleotide binding]
213810003170	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810003171	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810003172	Walker A/P-loop; other site
213810003173	ATP binding site [chemical binding]; other site
213810003174	Q-loop/lid; other site
213810003175	ABC transporter signature motif; other site
213810003176	Walker B; other site
213810003177	D-loop; other site
213810003178	H-loop/switch region; other site
213810003179	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
213810003180	FtsX-like permease family; Region: FtsX; pfam02687
213810003181	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
213810003182	FtsX-like permease family; Region: FtsX; pfam02687
213810003183	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
213810003184	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810003185	DNA binding residues [nucleotide binding]
213810003186	PemK-like protein; Region: PemK; pfam02452
213810003187	Helix-turn-helix domain; Region: HTH_17; pfam12728
213810003188	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
213810003189	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810003190	Int/Topo IB signature motif; other site
213810003191	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
213810003192	YabP family; Region: YabP; cl06766
213810003193	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
213810003194	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
213810003195	PhoH-like protein; Region: PhoH; pfam02562
213810003196	metal-binding heat shock protein; Provisional; Region: PRK00016
213810003197	GTPase Era; Reviewed; Region: era; PRK00089
213810003198	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
213810003199	G1 box; other site
213810003200	GTP/Mg2+ binding site [chemical binding]; other site
213810003201	Switch I region; other site
213810003202	G2 box; other site
213810003203	Switch II region; other site
213810003204	G3 box; other site
213810003205	G4 box; other site
213810003206	G5 box; other site
213810003207	KH domain; Region: KH_2; pfam07650
213810003208	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
213810003209	Recombination protein O N terminal; Region: RecO_N; pfam11967
213810003210	Recombination protein O C terminal; Region: RecO_C; pfam02565
213810003211	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
213810003212	MutS domain III; Region: MutS_III; pfam05192
213810003213	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
213810003214	Walker A/P-loop; other site
213810003215	ATP binding site [chemical binding]; other site
213810003216	Q-loop/lid; other site
213810003217	ABC transporter signature motif; other site
213810003218	Walker B; other site
213810003219	D-loop; other site
213810003220	H-loop/switch region; other site
213810003221	Smr domain; Region: Smr; pfam01713
213810003222	YcfA-like protein; Region: YcfA; pfam07927
213810003223	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
213810003224	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
213810003225	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
213810003226	Toprim-like; Region: Toprim_2; pfam13155
213810003227	helicase superfamily c-terminal domain; Region: HELICc; smart00490
213810003228	ATP-binding site [chemical binding]; other site
213810003229	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
213810003230	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
213810003231	FeoA domain; Region: FeoA; pfam04023
213810003232	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
213810003233	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
213810003234	G1 box; other site
213810003235	GTP/Mg2+ binding site [chemical binding]; other site
213810003236	Switch I region; other site
213810003237	G2 box; other site
213810003238	G3 box; other site
213810003239	Switch II region; other site
213810003240	G4 box; other site
213810003241	G5 box; other site
213810003242	Nucleoside recognition; Region: Gate; pfam07670
213810003243	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
213810003244	Nucleoside recognition; Region: Gate; pfam07670
213810003245	classical (c) SDRs; Region: SDR_c; cd05233
213810003246	NAD(P) binding site [chemical binding]; other site
213810003247	active site
213810003248	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
213810003249	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810003250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810003251	Walker A/P-loop; other site
213810003252	ATP binding site [chemical binding]; other site
213810003253	Q-loop/lid; other site
213810003254	ABC transporter signature motif; other site
213810003255	Walker B; other site
213810003256	D-loop; other site
213810003257	H-loop/switch region; other site
213810003258	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
213810003259	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
213810003260	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
213810003261	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
213810003262	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810003263	FeS/SAM binding site; other site
213810003264	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
213810003265	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
213810003266	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
213810003267	G1 box; other site
213810003268	GTP/Mg2+ binding site [chemical binding]; other site
213810003269	Switch I region; other site
213810003270	G2 box; other site
213810003271	Switch II region; other site
213810003272	G3 box; other site
213810003273	G4 box; other site
213810003274	G5 box; other site
213810003275	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
213810003276	active site
213810003277	Trp repressor protein; Region: Trp_repressor; cl17266
213810003278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810003279	S-adenosylmethionine binding site [chemical binding]; other site
213810003280	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
213810003281	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
213810003282	dimerization interface [polypeptide binding]; other site
213810003283	domain crossover interface; other site
213810003284	redox-dependent activation switch; other site
213810003285	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
213810003286	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
213810003287	nudix motif; other site
213810003288	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
213810003289	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
213810003290	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
213810003291	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
213810003292	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
213810003293	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
213810003294	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
213810003295	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
213810003296	23S rRNA binding site [nucleotide binding]; other site
213810003297	L21 binding site [polypeptide binding]; other site
213810003298	L13 binding site [polypeptide binding]; other site
213810003299	DNA protecting protein DprA; Region: dprA; TIGR00732
213810003300	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
213810003301	DNA topoisomerase I; Validated; Region: PRK05582
213810003302	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
213810003303	active site
213810003304	interdomain interaction site; other site
213810003305	putative metal-binding site [ion binding]; other site
213810003306	nucleotide binding site [chemical binding]; other site
213810003307	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
213810003308	domain I; other site
213810003309	DNA binding groove [nucleotide binding]
213810003310	phosphate binding site [ion binding]; other site
213810003311	domain II; other site
213810003312	domain III; other site
213810003313	nucleotide binding site [chemical binding]; other site
213810003314	catalytic site [active]
213810003315	domain IV; other site
213810003316	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
213810003317	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
213810003318	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
213810003319	Glucose inhibited division protein A; Region: GIDA; pfam01134
213810003320	putative phosphate acyltransferase; Provisional; Region: PRK05331
213810003321	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
213810003322	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810003323	FeS/SAM binding site; other site
213810003324	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
213810003325	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
213810003326	Walker A/P-loop; other site
213810003327	ATP binding site [chemical binding]; other site
213810003328	Q-loop/lid; other site
213810003329	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
213810003330	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
213810003331	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
213810003332	ABC transporter signature motif; other site
213810003333	Walker B; other site
213810003334	D-loop; other site
213810003335	H-loop/switch region; other site
213810003336	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
213810003337	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
213810003338	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
213810003339	P loop; other site
213810003340	GTP binding site [chemical binding]; other site
213810003341	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
213810003342	active site
213810003343	dimerization interface [polypeptide binding]; other site
213810003344	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
213810003345	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
213810003346	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
213810003347	active site
213810003348	(T/H)XGH motif; other site
213810003349	Transcriptional regulator [Transcription]; Region: LytR; COG1316
213810003350	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
213810003351	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
213810003352	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
213810003353	HIGH motif; other site
213810003354	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
213810003355	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810003356	active site
213810003357	KMSKS motif; other site
213810003358	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
213810003359	tRNA binding surface [nucleotide binding]; other site
213810003360	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
213810003361	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810003362	active site
213810003363	motif I; other site
213810003364	motif II; other site
213810003365	Dehydroquinase class II; Region: DHquinase_II; pfam01220
213810003366	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
213810003367	trimer interface [polypeptide binding]; other site
213810003368	active site
213810003369	dimer interface [polypeptide binding]; other site
213810003370	elongation factor P; Validated; Region: PRK00529
213810003371	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
213810003372	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
213810003373	RNA binding site [nucleotide binding]; other site
213810003374	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
213810003375	RNA binding site [nucleotide binding]; other site
213810003376	Predicted membrane protein [Function unknown]; Region: COG3601
213810003377	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
213810003378	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
213810003379	S-adenosylmethionine synthetase; Validated; Region: PRK05250
213810003380	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
213810003381	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
213810003382	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
213810003383	stage II sporulation protein D; Region: spore_II_D; TIGR02870
213810003384	Stage II sporulation protein; Region: SpoIID; pfam08486
213810003385	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
213810003386	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810003387	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
213810003388	AMP-binding domain protein; Validated; Region: PRK08315
213810003389	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810003390	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
213810003391	acyl-activating enzyme (AAE) consensus motif; other site
213810003392	acyl-activating enzyme (AAE) consensus motif; other site
213810003393	putative AMP binding site [chemical binding]; other site
213810003394	putative active site [active]
213810003395	putative CoA binding site [chemical binding]; other site
213810003396	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810003397	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
213810003398	acyl-activating enzyme (AAE) consensus motif; other site
213810003399	AMP binding site [chemical binding]; other site
213810003400	active site
213810003401	CoA binding site [chemical binding]; other site
213810003402	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810003403	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003404	non-specific DNA binding site [nucleotide binding]; other site
213810003405	salt bridge; other site
213810003406	sequence-specific DNA binding site [nucleotide binding]; other site
213810003407	Cupin domain; Region: Cupin_2; pfam07883
213810003408	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
213810003409	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
213810003410	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
213810003411	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
213810003412	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
213810003413	Potassium binding sites [ion binding]; other site
213810003414	Cesium cation binding sites [ion binding]; other site
213810003415	DNA replication protein DnaC; Validated; Region: PRK06835
213810003416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810003417	Walker A motif; other site
213810003418	ATP binding site [chemical binding]; other site
213810003419	Bacterial sugar transferase; Region: Bac_transf; pfam02397
213810003420	VanZ like family; Region: VanZ; pfam04892
213810003421	Chorismate mutase type II; Region: CM_2; pfam01817
213810003422	Prephenate dehydratase; Region: PDT; pfam00800
213810003423	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
213810003424	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
213810003425	putative L-Phe binding site [chemical binding]; other site
213810003426	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
213810003427	active site
213810003428	putative DNA-binding cleft [nucleotide binding]; other site
213810003429	dimer interface [polypeptide binding]; other site
213810003430	SseB protein; Region: SseB; cl06279
213810003431	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
213810003432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810003433	Walker A motif; other site
213810003434	ATP binding site [chemical binding]; other site
213810003435	Walker B motif; other site
213810003436	arginine finger; other site
213810003437	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
213810003438	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
213810003439	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
213810003440	active site
213810003441	substrate binding site [chemical binding]; other site
213810003442	metal binding site [ion binding]; metal-binding site
213810003443	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
213810003444	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
213810003445	Walker A/P-loop; other site
213810003446	ATP binding site [chemical binding]; other site
213810003447	Q-loop/lid; other site
213810003448	ABC transporter signature motif; other site
213810003449	Walker B; other site
213810003450	D-loop; other site
213810003451	H-loop/switch region; other site
213810003452	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
213810003453	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
213810003454	Emopamil binding protein; Region: EBP; pfam05241
213810003455	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
213810003456	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
213810003457	dimerization interface 3.5A [polypeptide binding]; other site
213810003458	active site
213810003459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810003460	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
213810003461	Walker A motif; other site
213810003462	ATP binding site [chemical binding]; other site
213810003463	Walker B motif; other site
213810003464	arginine finger; other site
213810003465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810003466	Walker A motif; other site
213810003467	ATP binding site [chemical binding]; other site
213810003468	Walker B motif; other site
213810003469	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
213810003470	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810003471	DNA binding residues [nucleotide binding]
213810003472	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810003473	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
213810003474	catalytic residues [active]
213810003475	catalytic nucleophile [active]
213810003476	Presynaptic Site I dimer interface [polypeptide binding]; other site
213810003477	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
213810003478	Synaptic Flat tetramer interface [polypeptide binding]; other site
213810003479	Synaptic Site I dimer interface [polypeptide binding]; other site
213810003480	DNA binding site [nucleotide binding]
213810003481	Recombinase; Region: Recombinase; pfam07508
213810003482	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
213810003483	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810003484	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003485	non-specific DNA binding site [nucleotide binding]; other site
213810003486	salt bridge; other site
213810003487	sequence-specific DNA binding site [nucleotide binding]; other site
213810003488	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810003489	Right handed beta helix region; Region: Beta_helix; pfam13229
213810003490	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810003491	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003492	non-specific DNA binding site [nucleotide binding]; other site
213810003493	salt bridge; other site
213810003494	sequence-specific DNA binding site [nucleotide binding]; other site
213810003495	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
213810003496	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
213810003497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810003498	catalytic residue [active]
213810003499	Putative esterase; Region: Esterase; pfam00756
213810003500	S-formylglutathione hydrolase; Region: PLN02442
213810003501	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
213810003502	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810003503	RNA binding surface [nucleotide binding]; other site
213810003504	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
213810003505	active site
213810003506	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
213810003507	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
213810003508	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
213810003509	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
213810003510	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
213810003511	ScpA/B protein; Region: ScpA_ScpB; cl00598
213810003512	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
213810003513	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
213810003514	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
213810003515	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
213810003516	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
213810003517	carboxyltransferase (CT) interaction site; other site
213810003518	biotinylation site [posttranslational modification]; other site
213810003519	oxaloacetate decarboxylase; Provisional; Region: PRK12331
213810003520	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
213810003521	active site
213810003522	catalytic residues [active]
213810003523	metal binding site [ion binding]; metal-binding site
213810003524	homodimer binding site [polypeptide binding]; other site
213810003525	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
213810003526	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
213810003527	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
213810003528	putative active site [active]
213810003529	putative metal binding site [ion binding]; other site
213810003530	stage II sporulation protein P; Region: spore_II_P; TIGR02867
213810003531	Response regulator receiver domain; Region: Response_reg; pfam00072
213810003532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810003533	active site
213810003534	phosphorylation site [posttranslational modification]
213810003535	intermolecular recognition site; other site
213810003536	dimerization interface [polypeptide binding]; other site
213810003537	LytTr DNA-binding domain; Region: LytTR; smart00850
213810003538	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
213810003539	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810003540	FeS/SAM binding site; other site
213810003541	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
213810003542	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
213810003543	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
213810003544	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
213810003545	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
213810003546	P-loop; other site
213810003547	Magnesium ion binding site [ion binding]; other site
213810003548	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
213810003549	Magnesium ion binding site [ion binding]; other site
213810003550	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
213810003551	Methyltransferase domain; Region: Methyltransf_26; pfam13659
213810003552	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
213810003553	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
213810003554	helicase superfamily c-terminal domain; Region: HELICc; smart00490
213810003555	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810003556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003557	non-specific DNA binding site [nucleotide binding]; other site
213810003558	salt bridge; other site
213810003559	sequence-specific DNA binding site [nucleotide binding]; other site
213810003560	HipA-like C-terminal domain; Region: HipA_C; pfam07804
213810003561	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
213810003562	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
213810003563	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
213810003564	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
213810003565	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
213810003566	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
213810003567	Ligand Binding Site [chemical binding]; other site
213810003568	FtsX-like permease family; Region: FtsX; pfam02687
213810003569	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
213810003570	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
213810003571	WHG domain; Region: WHG; pfam13305
213810003572	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
213810003573	TIGR04076 family protein; Region: TIGR04076
213810003574	Cupin domain; Region: Cupin_2; pfam07883
213810003575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810003576	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810003577	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810003578	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
213810003579	substrate binding site [chemical binding]; other site
213810003580	active site
213810003581	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
213810003582	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
213810003583	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810003584	ligand binding site [chemical binding]; other site
213810003585	dimerization interface [polypeptide binding]; other site
213810003586	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
213810003587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810003588	Pectate lyase; Region: Pec_lyase_C; cl01593
213810003589	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810003590	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
213810003591	putative sugar binding sites [chemical binding]; other site
213810003592	Q-X-W motif; other site
213810003593	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
213810003594	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
213810003595	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
213810003596	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
213810003597	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
213810003598	catalytic residues [active]
213810003599	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
213810003600	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
213810003601	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
213810003602	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
213810003603	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
213810003604	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
213810003605	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
213810003606	substrate binding site [chemical binding]; other site
213810003607	multimerization interface [polypeptide binding]; other site
213810003608	ATP binding site [chemical binding]; other site
213810003609	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
213810003610	thiamine phosphate binding site [chemical binding]; other site
213810003611	active site
213810003612	pyrophosphate binding site [ion binding]; other site
213810003613	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
213810003614	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234
213810003615	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
213810003616	active site
213810003617	catalytic site [active]
213810003618	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
213810003619	catalytic residue [active]
213810003620	ArsC family; Region: ArsC; pfam03960
213810003621	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
213810003622	putative deacylase active site [active]
213810003623	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
213810003624	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
213810003625	FAD binding pocket [chemical binding]; other site
213810003626	FAD binding motif [chemical binding]; other site
213810003627	phosphate binding motif [ion binding]; other site
213810003628	beta-alpha-beta structure motif; other site
213810003629	NAD binding pocket [chemical binding]; other site
213810003630	Iron coordination center [ion binding]; other site
213810003631	putative oxidoreductase; Provisional; Region: PRK12831
213810003632	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810003633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
213810003634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
213810003635	Preprotein translocase subunit; Region: YajC; pfam02699
213810003636	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
213810003637	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
213810003638	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
213810003639	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
213810003640	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
213810003641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810003642	CTP synthetase; Validated; Region: pyrG; PRK05380
213810003643	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
213810003644	Catalytic site [active]
213810003645	active site
213810003646	UTP binding site [chemical binding]; other site
213810003647	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
213810003648	active site
213810003649	putative oxyanion hole; other site
213810003650	catalytic triad [active]
213810003651	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810003652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810003653	dimer interface [polypeptide binding]; other site
213810003654	phosphorylation site [posttranslational modification]
213810003655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810003656	ATP binding site [chemical binding]; other site
213810003657	Mg2+ binding site [ion binding]; other site
213810003658	G-X-G motif; other site
213810003659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810003660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810003661	active site
213810003662	phosphorylation site [posttranslational modification]
213810003663	intermolecular recognition site; other site
213810003664	dimerization interface [polypeptide binding]; other site
213810003665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810003666	DNA binding site [nucleotide binding]
213810003667	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
213810003668	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
213810003669	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
213810003670	substrate binding site; other site
213810003671	dimer interface; other site
213810003672	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
213810003673	homotrimer interaction site [polypeptide binding]; other site
213810003674	zinc binding site [ion binding]; other site
213810003675	CDP-binding sites; other site
213810003676	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
213810003677	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
213810003678	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810003679	catalytic residue [active]
213810003680	Uncharacterized conserved protein [Function unknown]; Region: COG1624
213810003681	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
213810003682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
213810003683	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
213810003684	electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944
213810003685	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810003686	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
213810003687	4Fe-4S binding domain; Region: Fer4; pfam00037
213810003688	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
213810003689	electron transport complex RsxE subunit; Provisional; Region: PRK12405
213810003690	FMN-binding domain; Region: FMN_bind; cl01081
213810003691	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
213810003692	SLBB domain; Region: SLBB; pfam10531
213810003693	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810003694	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
213810003695	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
213810003696	trimer interface [polypeptide binding]; other site
213810003697	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
213810003698	ApbE family; Region: ApbE; pfam02424
213810003699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810003700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810003701	salt bridge; other site
213810003702	non-specific DNA binding site [nucleotide binding]; other site
213810003703	sequence-specific DNA binding site [nucleotide binding]; other site
213810003704	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
213810003705	catalytic core [active]
213810003706	S-ribosylhomocysteinase; Provisional; Region: PRK02260
213810003707	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
213810003708	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
213810003709	G5 domain; Region: G5; pfam07501
213810003710	Peptidase family M23; Region: Peptidase_M23; pfam01551
213810003711	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
213810003712	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
213810003713	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
213810003714	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
213810003715	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
213810003716	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
213810003717	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
213810003718	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
213810003719	putative translocon binding site; other site
213810003720	protein-rRNA interface [nucleotide binding]; other site
213810003721	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
213810003722	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
213810003723	G-X-X-G motif; other site
213810003724	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
213810003725	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
213810003726	23S rRNA interface [nucleotide binding]; other site
213810003727	5S rRNA interface [nucleotide binding]; other site
213810003728	putative antibiotic binding site [chemical binding]; other site
213810003729	L25 interface [polypeptide binding]; other site
213810003730	L27 interface [polypeptide binding]; other site
213810003731	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
213810003732	putative translocon interaction site; other site
213810003733	23S rRNA interface [nucleotide binding]; other site
213810003734	signal recognition particle (SRP54) interaction site; other site
213810003735	L23 interface [polypeptide binding]; other site
213810003736	trigger factor interaction site; other site
213810003737	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
213810003738	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
213810003739	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
213810003740	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
213810003741	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
213810003742	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
213810003743	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
213810003744	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
213810003745	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
213810003746	23S rRNA interface [nucleotide binding]; other site
213810003747	5S rRNA interface [nucleotide binding]; other site
213810003748	L27 interface [polypeptide binding]; other site
213810003749	L5 interface [polypeptide binding]; other site
213810003750	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
213810003751	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
213810003752	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
213810003753	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
213810003754	23S rRNA binding site [nucleotide binding]; other site
213810003755	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
213810003756	preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967
213810003757	SecY translocase; Region: SecY; pfam00344
213810003758	adenylate kinase; Reviewed; Region: adk; PRK00279
213810003759	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
213810003760	AMP-binding site [chemical binding]; other site
213810003761	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
213810003762	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
213810003763	active site
213810003764	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
213810003765	rRNA binding site [nucleotide binding]; other site
213810003766	predicted 30S ribosome binding site; other site
213810003767	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
213810003768	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
213810003769	30S ribosomal protein S13; Region: bact_S13; TIGR03631
213810003770	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
213810003771	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
213810003772	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810003773	RNA binding surface [nucleotide binding]; other site
213810003774	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
213810003775	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
213810003776	alphaNTD - beta interaction site [polypeptide binding]; other site
213810003777	alphaNTD homodimer interface [polypeptide binding]; other site
213810003778	alphaNTD - beta' interaction site [polypeptide binding]; other site
213810003779	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
213810003780	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
213810003781	cell division protein MraZ; Reviewed; Region: PRK00326
213810003782	MraZ protein; Region: MraZ; pfam02381
213810003783	MraZ protein; Region: MraZ; pfam02381
213810003784	MraW methylase family; Region: Methyltransf_5; cl17771
213810003785	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
213810003786	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
213810003787	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
213810003788	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
213810003789	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
213810003790	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
213810003791	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
213810003792	Mg++ binding site [ion binding]; other site
213810003793	putative catalytic motif [active]
213810003794	putative substrate binding site [chemical binding]; other site
213810003795	cell division protein FtsW; Region: ftsW; TIGR02614
213810003796	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
213810003797	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
213810003798	active site
213810003799	homodimer interface [polypeptide binding]; other site
213810003800	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
213810003801	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
213810003802	hinge; other site
213810003803	active site
213810003804	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
213810003805	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
213810003806	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
213810003807	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
213810003808	nucleotide binding site [chemical binding]; other site
213810003809	SulA interaction site; other site
213810003810	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
213810003811	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
213810003812	RNA polymerase factor sigma-70; Validated; Region: PRK08295
213810003813	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810003814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
213810003815	DNA binding residues [nucleotide binding]
213810003816	Probable zinc-binding domain; Region: zf-trcl; pfam13451
213810003817	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
213810003818	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
213810003819	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
213810003820	Family of unknown function (DUF633); Region: DUF633; pfam04816
213810003821	Uncharacterized conserved protein [Function unknown]; Region: COG0327
213810003822	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
213810003823	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
213810003824	Domain of unknown function (DUF814); Region: DUF814; pfam05670
213810003825	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
213810003826	active site
213810003827	DNA binding site [nucleotide binding]
213810003828	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
213810003829	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810003830	active site
213810003831	HIGH motif; other site
213810003832	nucleotide binding site [chemical binding]; other site
213810003833	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
213810003834	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
213810003835	active site
213810003836	KMSKS motif; other site
213810003837	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
213810003838	tRNA binding surface [nucleotide binding]; other site
213810003839	anticodon binding site; other site
213810003840	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
213810003841	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
213810003842	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
213810003843	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
213810003844	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
213810003845	DHHW protein; Region: DHHW; pfam14286
213810003846	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
213810003847	Acid Phosphatase; Region: Acid_PPase; cl17256
213810003848	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
213810003849	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
213810003850	Rubrerythrin [Energy production and conversion]; Region: COG1592
213810003851	binuclear metal center [ion binding]; other site
213810003852	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
213810003853	iron binding site [ion binding]; other site
213810003854	enolase; Provisional; Region: eno; PRK00077
213810003855	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
213810003856	dimer interface [polypeptide binding]; other site
213810003857	metal binding site [ion binding]; metal-binding site
213810003858	substrate binding pocket [chemical binding]; other site
213810003859	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
213810003860	putative metal binding site [ion binding]; other site
213810003861	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
213810003862	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
213810003863	putative metal binding site [ion binding]; other site
213810003864	NAD-dependent deacetylase; Provisional; Region: PRK00481
213810003865	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
213810003866	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
213810003867	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
213810003868	Protein of unknown function (DUF464); Region: DUF464; pfam04327
213810003869	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
213810003870	GTPase CgtA; Reviewed; Region: obgE; PRK12297
213810003871	GTP1/OBG; Region: GTP1_OBG; pfam01018
213810003872	Obg GTPase; Region: Obg; cd01898
213810003873	G1 box; other site
213810003874	GTP/Mg2+ binding site [chemical binding]; other site
213810003875	Switch I region; other site
213810003876	G2 box; other site
213810003877	G3 box; other site
213810003878	Switch II region; other site
213810003879	G4 box; other site
213810003880	G5 box; other site
213810003881	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
213810003882	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
213810003883	active site
213810003884	metal binding site [ion binding]; metal-binding site
213810003885	dimerization interface [polypeptide binding]; other site
213810003886	hypothetical protein; Validated; Region: PRK00110
213810003887	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
213810003888	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
213810003889	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
213810003890	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
213810003891	Cobalt transport protein; Region: CbiQ; cl00463
213810003892	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
213810003893	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
213810003894	Walker A/P-loop; other site
213810003895	ATP binding site [chemical binding]; other site
213810003896	Q-loop/lid; other site
213810003897	ABC transporter signature motif; other site
213810003898	Walker B; other site
213810003899	D-loop; other site
213810003900	H-loop/switch region; other site
213810003901	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
213810003902	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
213810003903	Walker A/P-loop; other site
213810003904	ATP binding site [chemical binding]; other site
213810003905	Q-loop/lid; other site
213810003906	ABC transporter signature motif; other site
213810003907	Walker B; other site
213810003908	D-loop; other site
213810003909	H-loop/switch region; other site
213810003910	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
213810003911	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
213810003912	hypothetical protein; Provisional; Region: PRK07208
213810003913	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
213810003914	UDP-galactopyranose mutase; Region: GLF; pfam03275
213810003915	Predicted membrane protein [Function unknown]; Region: COG2246
213810003916	GtrA-like protein; Region: GtrA; pfam04138
213810003917	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
213810003918	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
213810003919	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
213810003920	Tetramer interface [polypeptide binding]; other site
213810003921	active site
213810003922	FMN-binding site [chemical binding]; other site
213810003923	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
213810003924	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
213810003925	hinge; other site
213810003926	active site
213810003927	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
213810003928	active site
213810003929	dimer interface [polypeptide binding]; other site
213810003930	metal binding site [ion binding]; metal-binding site
213810003931	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
213810003932	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
213810003933	Maf-like protein; Reviewed; Region: PRK00078
213810003934	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
213810003935	active site
213810003936	dimer interface [polypeptide binding]; other site
213810003937	TspO/MBR family; Region: TspO_MBR; pfam03073
213810003938	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
213810003939	Part of AAA domain; Region: AAA_19; pfam13245
213810003940	Family description; Region: UvrD_C_2; pfam13538
213810003941	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
213810003942	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
213810003943	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
213810003944	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
213810003945	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
213810003946	Pectate lyase; Region: Pec_lyase_C; cl01593
213810003947	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810003948	putative sugar binding sites [chemical binding]; other site
213810003949	Q-X-W motif; other site
213810003950	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
213810003951	Sel1 repeat; Region: Sel1; cl02723
213810003952	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
213810003953	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
213810003954	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
213810003955	Sel1-like repeats; Region: SEL1; smart00671
213810003956	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
213810003957	Sel1-like repeats; Region: SEL1; smart00671
213810003958	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
213810003959	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
213810003960	metal ion-dependent adhesion site (MIDAS); other site
213810003961	Protein phosphatase 2C; Region: PP2C_2; pfam13672
213810003962	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
213810003963	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003964	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003965	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003966	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810003967	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
213810003968	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
213810003969	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
213810003970	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710
213810003971	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
213810003972	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
213810003973	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
213810003974	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
213810003975	oligomer interface [polypeptide binding]; other site
213810003976	active site
213810003977	metal binding site [ion binding]; metal-binding site
213810003978	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
213810003979	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
213810003980	oligomer interface [polypeptide binding]; other site
213810003981	active site
213810003982	metal binding site [ion binding]; metal-binding site
213810003983	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
213810003984	Aluminium resistance protein; Region: Alum_res; pfam06838
213810003985	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
213810003986	Catalytic domain of Protein Kinases; Region: PKc; cd00180
213810003987	active site
213810003988	ATP binding site [chemical binding]; other site
213810003989	substrate binding site [chemical binding]; other site
213810003990	activation loop (A-loop); other site
213810003991	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
213810003992	PASTA domain; Region: PASTA; smart00740
213810003993	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
213810003994	Na2 binding site [ion binding]; other site
213810003995	putative substrate binding site 1 [chemical binding]; other site
213810003996	Na binding site 1 [ion binding]; other site
213810003997	putative substrate binding site 2 [chemical binding]; other site
213810003998	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
213810003999	Part of AAA domain; Region: AAA_19; pfam13245
213810004000	Family description; Region: UvrD_C_2; pfam13538
213810004001	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810004002	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004003	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810004004	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
213810004005	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810004006	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
213810004007	substrate binding site [chemical binding]; other site
213810004008	active site
213810004009	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
213810004010	metal binding site [ion binding]; metal-binding site
213810004011	ligand binding site [chemical binding]; other site
213810004012	endoglucanase; Region: PLN02420
213810004013	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
213810004014	Cellulose binding domain; Region: CBM_3; pfam00942
213810004015	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810004016	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
213810004017	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
213810004018	Uncharacterized conserved protein [Function unknown]; Region: COG3937
213810004019	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
213810004020	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
213810004021	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
213810004022	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
213810004023	active site
213810004024	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
213810004025	DRTGG domain; Region: DRTGG; pfam07085
213810004026	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
213810004027	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
213810004028	Putative Fe-S cluster; Region: FeS; cl17515
213810004029	DRTGG domain; Region: DRTGG; pfam07085
213810004030	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
213810004031	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
213810004032	putative dimer interface [polypeptide binding]; other site
213810004033	[2Fe-2S] cluster binding site [ion binding]; other site
213810004034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810004035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810004036	ATP binding site [chemical binding]; other site
213810004037	Mg2+ binding site [ion binding]; other site
213810004038	G-X-G motif; other site
213810004039	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
213810004040	dimer interface [polypeptide binding]; other site
213810004041	[2Fe-2S] cluster binding site [ion binding]; other site
213810004042	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
213810004043	dimer interface [polypeptide binding]; other site
213810004044	[2Fe-2S] cluster binding site [ion binding]; other site
213810004045	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
213810004046	SLBB domain; Region: SLBB; pfam10531
213810004047	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
213810004048	4Fe-4S binding domain; Region: Fer4; pfam00037
213810004049	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
213810004050	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
213810004051	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
213810004052	catalytic loop [active]
213810004053	iron binding site [ion binding]; other site
213810004054	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
213810004055	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
213810004056	4Fe-4S binding domain; Region: Fer4; pfam00037
213810004057	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
213810004058	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
213810004059	Chromate transporter; Region: Chromate_transp; pfam02417
213810004060	Chromate transporter; Region: Chromate_transp; pfam02417
213810004061	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
213810004062	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
213810004063	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
213810004064	Phosphotransferase enzyme family; Region: APH; pfam01636
213810004065	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
213810004066	putative acetyltransferase; Provisional; Region: PRK03624
213810004067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810004068	Coenzyme A binding pocket [chemical binding]; other site
213810004069	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
213810004070	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
213810004071	Predicted membrane protein [Function unknown]; Region: COG4684
213810004072	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
213810004073	Domain of unknown function (DUF1893); Region: TM1506; pfam08973
213810004074	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
213810004075	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
213810004076	active site
213810004077	catalytic tetrad [active]
213810004078	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810004079	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
213810004080	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
213810004081	DNA binding residues [nucleotide binding]
213810004082	putative dimer interface [polypeptide binding]; other site
213810004083	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
213810004084	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
213810004085	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810004086	active site
213810004087	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
213810004088	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810004089	Coenzyme A binding pocket [chemical binding]; other site
213810004090	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
213810004091	active site
213810004092	catalytic motif [active]
213810004093	Zn binding site [ion binding]; other site
213810004094	Isochorismatase family; Region: Isochorismatase; pfam00857
213810004095	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
213810004096	catalytic triad [active]
213810004097	conserved cis-peptide bond; other site
213810004098	Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548
213810004099	dockerin binding interface; other site
213810004100	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
213810004101	Ca binding site [ion binding]; other site
213810004102	Ca binding site (active) [ion binding]; other site
213810004103	ligand binding site [chemical binding]; other site
213810004104	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
213810004105	metal binding site [ion binding]; metal-binding site
213810004106	active site
213810004107	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
213810004108	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
213810004109	iron-sulfur cluster [ion binding]; other site
213810004110	[2Fe-2S] cluster binding site [ion binding]; other site
213810004111	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810004112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810004113	non-specific DNA binding site [nucleotide binding]; other site
213810004114	salt bridge; other site
213810004115	sequence-specific DNA binding site [nucleotide binding]; other site
213810004116	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
213810004117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
213810004118	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
213810004119	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810004120	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
213810004121	Walker A/P-loop; other site
213810004122	ATP binding site [chemical binding]; other site
213810004123	Q-loop/lid; other site
213810004124	ABC transporter signature motif; other site
213810004125	Walker B; other site
213810004126	D-loop; other site
213810004127	H-loop/switch region; other site
213810004128	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
213810004129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
213810004130	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
213810004131	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
213810004132	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810004134	ATP binding site [chemical binding]; other site
213810004135	G-X-G motif; other site
213810004136	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
213810004137	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
213810004138	dimer interface [polypeptide binding]; other site
213810004139	active site
213810004140	metal binding site [ion binding]; metal-binding site
213810004141	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
213810004142	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
213810004143	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
213810004144	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
213810004145	trimer interface [polypeptide binding]; other site
213810004146	active site
213810004147	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
213810004148	catalytic site [active]
213810004149	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
213810004150	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
213810004151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004153	homoserine dehydrogenase; Provisional; Region: PRK06349
213810004154	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
213810004155	hypothetical protein; Provisional; Region: PRK04435
213810004156	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
213810004157	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
213810004158	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
213810004159	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
213810004160	RmuC family; Region: RmuC; pfam02646
213810004161	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
213810004162	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
213810004163	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
213810004164	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
213810004165	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
213810004166	Hpr binding site; other site
213810004167	active site
213810004168	homohexamer subunit interaction site [polypeptide binding]; other site
213810004169	putative hydrolase; Validated; Region: PRK09248
213810004170	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
213810004171	active site
213810004172	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
213810004173	FAD binding domain; Region: FAD_binding_4; pfam01565
213810004174	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
213810004175	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
213810004176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
213810004177	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
213810004178	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
213810004179	active site
213810004180	PHP Thumb interface [polypeptide binding]; other site
213810004181	metal binding site [ion binding]; metal-binding site
213810004182	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
213810004183	generic binding surface I; other site
213810004184	generic binding surface II; other site
213810004185	6-phosphofructokinase; Provisional; Region: PRK03202
213810004186	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
213810004187	active site
213810004188	ADP/pyrophosphate binding site [chemical binding]; other site
213810004189	dimerization interface [polypeptide binding]; other site
213810004190	allosteric effector site; other site
213810004191	fructose-1,6-bisphosphate binding site; other site
213810004192	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
213810004193	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
213810004194	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
213810004195	16S/18S rRNA binding site [nucleotide binding]; other site
213810004196	S13e-L30e interaction site [polypeptide binding]; other site
213810004197	25S rRNA binding site [nucleotide binding]; other site
213810004198	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
213810004199	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
213810004200	RNase E interface [polypeptide binding]; other site
213810004201	trimer interface [polypeptide binding]; other site
213810004202	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
213810004203	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
213810004204	RNase E interface [polypeptide binding]; other site
213810004205	trimer interface [polypeptide binding]; other site
213810004206	active site
213810004207	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
213810004208	putative nucleic acid binding region [nucleotide binding]; other site
213810004209	G-X-X-G motif; other site
213810004210	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
213810004211	RNA binding site [nucleotide binding]; other site
213810004212	domain interface; other site
213810004213	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
213810004214	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
213810004215	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
213810004216	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
213810004217	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
213810004218	catalytic triad [active]
213810004219	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
213810004220	active site
213810004221	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
213810004222	Propanediol utilisation protein PduL; Region: PduL; pfam06130
213810004223	Propanediol utilisation protein PduL; Region: PduL; pfam06130
213810004224	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
213810004225	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
213810004226	active site
213810004227	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
213810004228	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
213810004229	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
213810004230	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
213810004231	homodimer interface [polypeptide binding]; other site
213810004232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810004233	catalytic residue [active]
213810004234	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
213810004235	spermidine synthase; Provisional; Region: PRK00811
213810004236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810004237	S-adenosylmethionine binding site [chemical binding]; other site
213810004238	agmatinase; Region: agmatinase; TIGR01230
213810004239	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
213810004240	putative active site [active]
213810004241	Mn binding site [ion binding]; other site
213810004242	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
213810004243	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
213810004244	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
213810004245	dimer interface [polypeptide binding]; other site
213810004246	active site
213810004247	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
213810004248	catalytic residues [active]
213810004249	substrate binding site [chemical binding]; other site
213810004250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810004251	non-specific DNA binding site [nucleotide binding]; other site
213810004252	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
213810004253	salt bridge; other site
213810004254	sequence-specific DNA binding site [nucleotide binding]; other site
213810004255	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
213810004256	Catalytic site [active]
213810004257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
213810004258	non-specific DNA binding site [nucleotide binding]; other site
213810004259	salt bridge; other site
213810004260	sequence-specific DNA binding site [nucleotide binding]; other site
213810004261	Prophage antirepressor [Transcription]; Region: COG3617
213810004262	BRO family, N-terminal domain; Region: Bro-N; smart01040
213810004263	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
213810004264	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
213810004265	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
213810004266	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810004267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810004268	non-specific DNA binding site [nucleotide binding]; other site
213810004269	salt bridge; other site
213810004270	sequence-specific DNA binding site [nucleotide binding]; other site
213810004271	RecT family; Region: RecT; cl04285
213810004272	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
213810004273	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
213810004274	dimer interface [polypeptide binding]; other site
213810004275	ssDNA binding site [nucleotide binding]; other site
213810004276	tetramer (dimer of dimers) interface [polypeptide binding]; other site
213810004277	hypothetical protein; Validated; Region: PRK08116
213810004278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810004279	Walker A motif; other site
213810004280	ATP binding site [chemical binding]; other site
213810004281	Walker B motif; other site
213810004282	arginine finger; other site
213810004283	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
213810004284	CRISPR/Cas system-associated protein Csf1; Region: Csf1_U; cd09705
213810004285	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
213810004286	Ligand Binding Site [chemical binding]; other site
213810004287	YopX protein; Region: YopX; pfam09643
213810004288	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
213810004289	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
213810004290	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
213810004291	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
213810004292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810004293	DNA binding residues [nucleotide binding]
213810004294	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810004295	SdiA-regulated; Region: SdiA-regulated; cd09971
213810004296	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
213810004297	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
213810004298	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
213810004299	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
213810004300	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810004301	Int/Topo IB signature motif; other site
213810004302	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
213810004303	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
213810004304	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
213810004305	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
213810004306	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
213810004307	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
213810004308	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
213810004309	Minor capsid protein; Region: Minor_capsid_2; pfam11114
213810004310	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
213810004311	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
213810004312	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
213810004313	Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674
213810004314	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
213810004315	Phage terminase large subunit; Region: Terminase_3; cl12054
213810004316	Terminase-like family; Region: Terminase_6; pfam03237
213810004317	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
213810004318	transcriptional activator RfaH; Region: RfaH; TIGR01955
213810004319	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
213810004320	Mor transcription activator family; Region: Mor; cl02360
213810004321	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
213810004322	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
213810004323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004324	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
213810004325	putative efflux protein, MATE family; Region: matE; TIGR00797
213810004326	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
213810004327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810004328	non-specific DNA binding site [nucleotide binding]; other site
213810004329	salt bridge; other site
213810004330	sequence-specific DNA binding site [nucleotide binding]; other site
213810004331	Domain of unknown function (DUF955); Region: DUF955; pfam06114
213810004332	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
213810004333	Protein of unknown function DUF45; Region: DUF45; pfam01863
213810004334	EDD domain protein, DegV family; Region: DegV; TIGR00762
213810004335	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
213810004336	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
213810004337	active site
213810004338	catalytic site [active]
213810004339	aconitate hydratase-like protein; Provisional; Region: PTZ00092
213810004340	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
213810004341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810004342	Coenzyme A binding pocket [chemical binding]; other site
213810004343	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
213810004344	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
213810004345	ATP binding site [chemical binding]; other site
213810004346	Mg++ binding site [ion binding]; other site
213810004347	motif III; other site
213810004348	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
213810004349	nucleotide binding region [chemical binding]; other site
213810004350	ATP-binding site [chemical binding]; other site
213810004351	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
213810004352	RNA binding site [nucleotide binding]; other site
213810004353	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
213810004354	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
213810004355	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
213810004356	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
213810004357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810004358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004359	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
213810004360	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
213810004361	Na binding site [ion binding]; other site
213810004362	Fn3 associated; Region: Fn3_assoc; pfam13287
213810004363	CotH protein; Region: CotH; pfam08757
213810004364	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
213810004365	IHF dimer interface [polypeptide binding]; other site
213810004366	IHF - DNA interface [nucleotide binding]; other site
213810004367	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
213810004368	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
213810004369	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
213810004370	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
213810004371	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
213810004372	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
213810004373	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
213810004374	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
213810004375	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
213810004376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810004377	homodimer interface [polypeptide binding]; other site
213810004378	catalytic residue [active]
213810004379	HD domain; Region: HD; pfam01966
213810004380	WYL domain; Region: WYL; pfam13280
213810004381	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
213810004382	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
213810004383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810004384	S-adenosylmethionine binding site [chemical binding]; other site
213810004385	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
213810004386	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
213810004387	active site
213810004388	metal binding site [ion binding]; metal-binding site
213810004389	sporulation sigma factor SigG; Reviewed; Region: PRK08215
213810004390	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810004391	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
213810004392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810004393	DNA binding residues [nucleotide binding]
213810004394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810004395	Coenzyme A binding pocket [chemical binding]; other site
213810004396	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
213810004397	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
213810004398	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
213810004399	membrane-bound complex binding site; other site
213810004400	hinge residues; other site
213810004401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
213810004402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
213810004403	substrate binding pocket [chemical binding]; other site
213810004404	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
213810004405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810004406	dimer interface [polypeptide binding]; other site
213810004407	conserved gate region; other site
213810004408	putative PBP binding loops; other site
213810004409	ABC-ATPase subunit interface; other site
213810004410	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
213810004411	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810004412	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
213810004413	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810004414	Radical SAM superfamily; Region: Radical_SAM; pfam04055
213810004415	FeS/SAM binding site; other site
213810004416	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
213810004417	AIR carboxylase; Region: AIRC; pfam00731
213810004418	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
213810004419	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
213810004420	ATP binding site [chemical binding]; other site
213810004421	active site
213810004422	substrate binding site [chemical binding]; other site
213810004423	amidophosphoribosyltransferase; Provisional; Region: PRK06781
213810004424	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
213810004425	active site
213810004426	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810004427	active site
213810004428	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
213810004429	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
213810004430	dimerization interface [polypeptide binding]; other site
213810004431	putative ATP binding site [chemical binding]; other site
213810004432	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
213810004433	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
213810004434	active site
213810004435	substrate binding site [chemical binding]; other site
213810004436	cosubstrate binding site; other site
213810004437	catalytic site [active]
213810004438	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
213810004439	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
213810004440	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
213810004441	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
213810004442	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
213810004443	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
213810004444	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
213810004445	Putative methyltransferase; Region: Methyltransf_4; cl17290
213810004446	dihydroorotase; Validated; Region: pyrC; PRK09357
213810004447	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
213810004448	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
213810004449	active site
213810004450	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
213810004451	active site
213810004452	dimer interface [polypeptide binding]; other site
213810004453	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
213810004454	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
213810004455	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
213810004456	catalytic site [active]
213810004457	subunit interface [polypeptide binding]; other site
213810004458	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
213810004459	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
213810004460	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
213810004461	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
213810004462	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
213810004463	ATP-grasp domain; Region: ATP-grasp_4; cl17255
213810004464	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
213810004465	IMP binding site; other site
213810004466	dimer interface [polypeptide binding]; other site
213810004467	interdomain contacts; other site
213810004468	partial ornithine binding site; other site
213810004469	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
213810004470	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
213810004471	FAD binding pocket [chemical binding]; other site
213810004472	FAD binding motif [chemical binding]; other site
213810004473	phosphate binding motif [ion binding]; other site
213810004474	beta-alpha-beta structure motif; other site
213810004475	NAD binding pocket [chemical binding]; other site
213810004476	Iron coordination center [ion binding]; other site
213810004477	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
213810004478	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
213810004479	heterodimer interface [polypeptide binding]; other site
213810004480	active site
213810004481	FMN binding site [chemical binding]; other site
213810004482	homodimer interface [polypeptide binding]; other site
213810004483	substrate binding site [chemical binding]; other site
213810004484	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
213810004485	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
213810004486	EDD domain protein, DegV family; Region: DegV; TIGR00762
213810004487	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
213810004488	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
213810004489	Dockerin type I repeat; Region: Dockerin_1; pfam00404
213810004490	Phosphoglycerate kinase; Region: PGK; pfam00162
213810004491	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
213810004492	substrate binding site [chemical binding]; other site
213810004493	hinge regions; other site
213810004494	ADP binding site [chemical binding]; other site
213810004495	catalytic site [active]
213810004496	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
213810004497	triosephosphate isomerase; Provisional; Region: PRK14565
213810004498	substrate binding site [chemical binding]; other site
213810004499	dimer interface [polypeptide binding]; other site
213810004500	catalytic triad [active]
213810004501	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
213810004502	phosphoglyceromutase; Provisional; Region: PRK05434
213810004503	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810004504	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
213810004505	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
213810004506	Ligand binding site; other site
213810004507	metal-binding site
213810004508	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
213810004509	active site
213810004510	metal binding site [ion binding]; metal-binding site
213810004511	Bacterial SH3 domain; Region: SH3_3; pfam08239
213810004512	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
213810004513	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
213810004514	Walker A motif; other site
213810004515	ATP binding site [chemical binding]; other site
213810004516	Walker B motif; other site
213810004517	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
213810004518	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
213810004519	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
213810004520	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
213810004521	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
213810004522	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
213810004523	Asp23 family; Region: Asp23; cl00574
213810004524	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
213810004525	putative RNA binding site [nucleotide binding]; other site
213810004526	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
213810004527	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
213810004528	generic binding surface II; other site
213810004529	generic binding surface I; other site
213810004530	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
213810004531	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
213810004532	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
213810004533	substrate binding pocket [chemical binding]; other site
213810004534	chain length determination region; other site
213810004535	substrate-Mg2+ binding site; other site
213810004536	catalytic residues [active]
213810004537	aspartate-rich region 1; other site
213810004538	active site lid residues [active]
213810004539	aspartate-rich region 2; other site
213810004540	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
213810004541	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
213810004542	TPP-binding site; other site
213810004543	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
213810004544	PYR/PP interface [polypeptide binding]; other site
213810004545	dimer interface [polypeptide binding]; other site
213810004546	TPP binding site [chemical binding]; other site
213810004547	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
213810004548	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
213810004549	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
213810004550	RNA binding surface [nucleotide binding]; other site
213810004551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810004552	S-adenosylmethionine binding site [chemical binding]; other site
213810004553	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
213810004554	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
213810004555	arginine repressor; Provisional; Region: argR; PRK00441
213810004556	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
213810004557	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
213810004558	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
213810004559	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
213810004560	Walker A/P-loop; other site
213810004561	ATP binding site [chemical binding]; other site
213810004562	Q-loop/lid; other site
213810004563	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
213810004564	ABC transporter signature motif; other site
213810004565	Walker B; other site
213810004566	D-loop; other site
213810004567	H-loop/switch region; other site
213810004568	RNA polymerase sigma factor; Provisional; Region: PRK11924
213810004569	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810004570	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810004571	DNA binding residues [nucleotide binding]
213810004572	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
213810004573	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
213810004574	Soluble P-type ATPase [General function prediction only]; Region: COG4087
213810004575	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
213810004576	metal-binding site [ion binding]
213810004577	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
213810004578	dimerization interface [polypeptide binding]; other site
213810004579	putative DNA binding site [nucleotide binding]; other site
213810004580	putative Zn2+ binding site [ion binding]; other site
213810004581	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
213810004582	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
213810004583	putative active site [active]
213810004584	metal binding site [ion binding]; metal-binding site
213810004585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
213810004586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
213810004587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
213810004588	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
213810004589	DNA binding site [nucleotide binding]
213810004590	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
213810004591	active site
213810004592	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
213810004593	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810004594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
213810004596	Major Facilitator Superfamily; Region: MFS_1; pfam07690
213810004597	putative substrate translocation pore; other site
213810004598	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
213810004599	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
213810004600	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
213810004601	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
213810004602	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
213810004603	GIY-YIG motif/motif A; other site
213810004604	active site
213810004605	catalytic site [active]
213810004606	putative DNA binding site [nucleotide binding]; other site
213810004607	metal binding site [ion binding]; metal-binding site
213810004608	UvrB/uvrC motif; Region: UVR; pfam02151
213810004609	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
213810004610	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
213810004611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
213810004612	S-adenosylmethionine binding site [chemical binding]; other site
213810004613	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
213810004614	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
213810004615	active site
213810004616	(T/H)XGH motif; other site
213810004617	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
213810004618	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810004619	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810004620	DNA binding residues [nucleotide binding]
213810004621	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
213810004622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
213810004623	dimer interface [polypeptide binding]; other site
213810004624	phosphorylation site [posttranslational modification]
213810004625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810004626	ATP binding site [chemical binding]; other site
213810004627	Mg2+ binding site [ion binding]; other site
213810004628	G-X-G motif; other site
213810004629	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
213810004630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810004631	active site
213810004632	phosphorylation site [posttranslational modification]
213810004633	intermolecular recognition site; other site
213810004634	dimerization interface [polypeptide binding]; other site
213810004635	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
213810004636	DNA binding site [nucleotide binding]
213810004637	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
213810004638	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
213810004639	ABC-ATPase subunit  interface; other site
213810004640	dimer interface [polypeptide binding]; other site
213810004641	putative PBP binding regions; other site
213810004642	Domain of unknown function DUF20; Region: UPF0118; pfam01594
213810004643	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
213810004644	Quinolinate synthetase A protein; Region: NadA; pfam02445
213810004645	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
213810004646	active site
213810004647	catalytic triad [active]
213810004648	oxyanion hole [active]
213810004649	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
213810004650	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
213810004651	putative sugar binding sites [chemical binding]; other site
213810004652	Q-X-W motif; other site
213810004653	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
213810004654	Ca binding site [ion binding]; other site
213810004655	Ca binding site (active) [ion binding]; other site
213810004656	ligand binding site [chemical binding]; other site
213810004657	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
213810004658	active site
213810004659	catalytic triad [active]
213810004660	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
213810004661	active site
213810004662	catalytic triad [active]
213810004663	oxyanion hole [active]
213810004664	Uncharacterized conserved protein [Function unknown]; Region: COG1284
213810004665	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
213810004666	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
213810004667	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
213810004668	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
213810004669	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
213810004670	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
213810004671	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
213810004672	Biotin operon repressor [Transcription]; Region: BirA; COG1654
213810004673	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
213810004674	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
213810004675	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
213810004676	AAA domain; Region: AAA_30; pfam13604
213810004677	Family description; Region: UvrD_C_2; pfam13538
213810004678	comF family protein; Region: comF; TIGR00201
213810004679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810004680	active site
213810004681	rod shape-determining protein MreB; Provisional; Region: PRK13930
213810004682	MreB and similar proteins; Region: MreB_like; cd10225
213810004683	nucleotide binding site [chemical binding]; other site
213810004684	Mg binding site [ion binding]; other site
213810004685	putative protofilament interaction site [polypeptide binding]; other site
213810004686	RodZ interaction site [polypeptide binding]; other site
213810004687	phosphodiesterase YaeI; Provisional; Region: PRK11340
213810004688	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
213810004689	putative active site [active]
213810004690	putative metal binding site [ion binding]; other site
213810004691	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
213810004692	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
213810004693	rRNA interaction site [nucleotide binding]; other site
213810004694	S8 interaction site; other site
213810004695	putative laminin-1 binding site; other site
213810004696	elongation factor Ts; Provisional; Region: tsf; PRK09377
213810004697	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
213810004698	Elongation factor TS; Region: EF_TS; pfam00889
213810004699	Elongation factor TS; Region: EF_TS; pfam00889
213810004700	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
213810004701	putative nucleotide binding site [chemical binding]; other site
213810004702	uridine monophosphate binding site [chemical binding]; other site
213810004703	homohexameric interface [polypeptide binding]; other site
213810004704	ribosome recycling factor; Reviewed; Region: frr; PRK00083
213810004705	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
213810004706	hinge region; other site
213810004707	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
213810004708	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
213810004709	catalytic residue [active]
213810004710	putative FPP diphosphate  binding site; other site
213810004711	putative FPP binding hydrophobic cleft; other site
213810004712	dimer interface [polypeptide binding]; other site
213810004713	putative IPP diphosphate binding site; other site
213810004714	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
213810004715	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
213810004716	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
213810004717	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
213810004718	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
213810004719	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
213810004720	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
213810004721	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
213810004722	active site
213810004723	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
213810004724	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
213810004725	putative substrate binding region [chemical binding]; other site
213810004726	DNA polymerase III PolC; Validated; Region: polC; PRK00448
213810004727	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
213810004728	generic binding surface II; other site
213810004729	generic binding surface I; other site
213810004730	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
213810004731	active site
213810004732	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
213810004733	active site
213810004734	catalytic site [active]
213810004735	substrate binding site [chemical binding]; other site
213810004736	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
213810004737	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
213810004738	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
213810004739	dimer interface [polypeptide binding]; other site
213810004740	motif 1; other site
213810004741	active site
213810004742	motif 2; other site
213810004743	motif 3; other site
213810004744	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
213810004745	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
213810004746	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
213810004747	histidinol dehydrogenase; Region: hisD; TIGR00069
213810004748	NAD binding site [chemical binding]; other site
213810004749	dimerization interface [polypeptide binding]; other site
213810004750	product binding site; other site
213810004751	substrate binding site [chemical binding]; other site
213810004752	zinc binding site [ion binding]; other site
213810004753	catalytic residues [active]
213810004754	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
213810004755	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
213810004756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810004757	homodimer interface [polypeptide binding]; other site
213810004758	catalytic residue [active]
213810004759	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
213810004760	putative active site pocket [active]
213810004761	4-fold oligomerization interface [polypeptide binding]; other site
213810004762	metal binding residues [ion binding]; metal-binding site
213810004763	3-fold/trimer interface [polypeptide binding]; other site
213810004764	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
213810004765	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
213810004766	putative active site [active]
213810004767	oxyanion strand; other site
213810004768	catalytic triad [active]
213810004769	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
213810004770	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
213810004771	catalytic residues [active]
213810004772	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
213810004773	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
213810004774	substrate binding site [chemical binding]; other site
213810004775	glutamase interaction surface [polypeptide binding]; other site
213810004776	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
213810004777	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
213810004778	metal binding site [ion binding]; metal-binding site
213810004779	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
213810004780	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
213810004781	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
213810004782	nucleotide binding pocket [chemical binding]; other site
213810004783	K-X-D-G motif; other site
213810004784	catalytic site [active]
213810004785	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
213810004786	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
213810004787	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
213810004788	Dimer interface [polypeptide binding]; other site
213810004789	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
213810004790	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
213810004791	active site
213810004792	DNA binding site [nucleotide binding]
213810004793	Int/Topo IB signature motif; other site
213810004794	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
213810004795	dipeptidase PepV; Reviewed; Region: PRK07318
213810004796	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
213810004797	active site
213810004798	metal binding site [ion binding]; metal-binding site
213810004799	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
213810004800	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
213810004801	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
213810004802	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
213810004803	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
213810004804	Helix-turn-helix domain; Region: HTH_36; pfam13730
213810004805	Helix-turn-helix domain; Region: HTH_36; pfam13730
213810004806	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
213810004807	Maff2 family; Region: Maff2; pfam12750
213810004808	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
213810004809	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
213810004810	PrgI family protein; Region: PrgI; pfam12666
213810004811	AAA-like domain; Region: AAA_10; pfam12846
213810004812	Domain of unknown function DUF87; Region: DUF87; pfam01935
213810004813	PIN domain; Region: PIN_3; pfam13470
213810004814	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
213810004815	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
213810004816	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
213810004817	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810004818	cofactor binding site; other site
213810004819	DNA binding site [nucleotide binding]
213810004820	substrate interaction site [chemical binding]; other site
213810004821	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
213810004822	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
213810004823	Ligand Binding Site [chemical binding]; other site
213810004824	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
213810004825	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
213810004826	Interdomain contacts; other site
213810004827	Cytokine receptor motif; other site
213810004828	MarR family; Region: MarR_2; cl17246
213810004829	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
213810004830	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
213810004831	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
213810004832	active site
213810004833	putative interdomain interaction site [polypeptide binding]; other site
213810004834	putative metal-binding site [ion binding]; other site
213810004835	putative nucleotide binding site [chemical binding]; other site
213810004836	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
213810004837	domain I; other site
213810004838	DNA binding groove [nucleotide binding]
213810004839	phosphate binding site [ion binding]; other site
213810004840	domain II; other site
213810004841	domain III; other site
213810004842	nucleotide binding site [chemical binding]; other site
213810004843	catalytic site [active]
213810004844	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
213810004845	Toprim-like; Region: Toprim_2; pfam13155
213810004846	YodL-like; Region: YodL; pfam14191
213810004847	MutS domain I; Region: MutS_I; pfam01624
213810004848	Methyltransferase domain; Region: Methyltransf_26; pfam13659
213810004849	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810004850	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
213810004851	catalytic residues [active]
213810004852	catalytic nucleophile [active]
213810004853	Recombinase; Region: Recombinase; pfam07508
213810004854	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
213810004855	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
213810004856	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
213810004857	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
213810004858	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
213810004859	catalytic residues [active]
213810004860	catalytic nucleophile [active]
213810004861	Presynaptic Site I dimer interface [polypeptide binding]; other site
213810004862	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
213810004863	Synaptic Flat tetramer interface [polypeptide binding]; other site
213810004864	Staphylococcal AgrD protein; Region: AgrD; cl05477
213810004865	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
213810004866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810004867	active site
213810004868	phosphorylation site [posttranslational modification]
213810004869	intermolecular recognition site; other site
213810004870	LytTr DNA-binding domain; Region: LytTR; pfam04397
213810004871	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
213810004872	DEAD-like helicases superfamily; Region: DEXDc; smart00487
213810004873	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
213810004874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
213810004875	WYL domain; Region: WYL; pfam13280
213810004876	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
213810004877	active site
213810004878	catalytic site [active]
213810004879	substrate binding site [chemical binding]; other site
213810004880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810004881	salt bridge; other site
213810004882	non-specific DNA binding site [nucleotide binding]; other site
213810004883	sequence-specific DNA binding site [nucleotide binding]; other site
213810004884	Helix-turn-helix domain; Region: HTH_17; pfam12728
213810004885	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
213810004886	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
213810004887	Int/Topo IB signature motif; other site
213810004888	dihydrodipicolinate reductase; Provisional; Region: PRK00048
213810004889	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
213810004890	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
213810004891	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
213810004892	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
213810004893	dimer interface [polypeptide binding]; other site
213810004894	active site
213810004895	catalytic residue [active]
213810004896	thymidine kinase; Provisional; Region: PRK04296
213810004897	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
213810004898	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
213810004899	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
213810004900	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
213810004901	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
213810004902	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
213810004903	phosphoglycolate phosphatase; Provisional; Region: PRK13222
213810004904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
213810004905	motif II; other site
213810004906	Mechanosensitive ion channel; Region: MS_channel; pfam00924
213810004907	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
213810004908	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
213810004909	putative active site [active]
213810004910	putative metal binding site [ion binding]; other site
213810004911	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
213810004912	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
213810004913	minor groove reading motif; other site
213810004914	helix-hairpin-helix signature motif; other site
213810004915	substrate binding pocket [chemical binding]; other site
213810004916	active site
213810004917	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
213810004918	DNA binding and oxoG recognition site [nucleotide binding]
213810004919	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
213810004920	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
213810004921	Protein of unknown function DUF58; Region: DUF58; pfam01882
213810004922	MoxR-like ATPases [General function prediction only]; Region: COG0714
213810004923	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810004924	Walker A motif; other site
213810004925	ATP binding site [chemical binding]; other site
213810004926	Walker B motif; other site
213810004927	arginine finger; other site
213810004928	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
213810004929	dimer interface [polypeptide binding]; other site
213810004930	substrate binding site [chemical binding]; other site
213810004931	metal binding sites [ion binding]; metal-binding site
213810004932	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
213810004933	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
213810004934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
213810004935	active site
213810004936	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810004937	dimerization interface [polypeptide binding]; other site
213810004938	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
213810004939	ligand binding site [chemical binding]; other site
213810004940	Helix-turn-helix domain; Region: HTH_18; pfam12833
213810004941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810004942	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
213810004943	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
213810004944	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
213810004945	putative metal binding site [ion binding]; other site
213810004946	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
213810004947	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
213810004948	GGGtGRT protein; Region: GGGtGRT; pfam14057
213810004949	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
213810004950	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
213810004951	substrate binding pocket [chemical binding]; other site
213810004952	membrane-bound complex binding site; other site
213810004953	hinge residues; other site
213810004954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810004955	dimer interface [polypeptide binding]; other site
213810004956	conserved gate region; other site
213810004957	putative PBP binding loops; other site
213810004958	ABC-ATPase subunit interface; other site
213810004959	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
213810004960	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
213810004961	Walker A/P-loop; other site
213810004962	ATP binding site [chemical binding]; other site
213810004963	Q-loop/lid; other site
213810004964	ABC transporter signature motif; other site
213810004965	Walker B; other site
213810004966	D-loop; other site
213810004967	H-loop/switch region; other site
213810004968	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
213810004969	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
213810004970	Coenzyme A binding pocket [chemical binding]; other site
213810004971	Survival protein SurE; Region: SurE; cl00448
213810004972	2-isopropylmalate synthase; Validated; Region: PRK03739
213810004973	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
213810004974	active site
213810004975	catalytic residues [active]
213810004976	metal binding site [ion binding]; metal-binding site
213810004977	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
213810004978	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
213810004979	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
213810004980	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
213810004981	TMP-binding site; other site
213810004982	ATP-binding site [chemical binding]; other site
213810004983	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
213810004984	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
213810004985	DJ-1 family protein; Region: not_thiJ; TIGR01383
213810004986	conserved cys residue [active]
213810004987	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
213810004988	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
213810004989	YceG-like family; Region: YceG; pfam02618
213810004990	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
213810004991	dimerization interface [polypeptide binding]; other site
213810004992	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
213810004993	Peptidase family U32; Region: Peptidase_U32; pfam01136
213810004994	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
213810004995	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
213810004996	Walker A/P-loop; other site
213810004997	ATP binding site [chemical binding]; other site
213810004998	Q-loop/lid; other site
213810004999	ABC transporter signature motif; other site
213810005000	Walker B; other site
213810005001	D-loop; other site
213810005002	H-loop/switch region; other site
213810005003	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
213810005004	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
213810005005	FtsX-like permease family; Region: FtsX; pfam02687
213810005006	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
213810005007	FtsX-like permease family; Region: FtsX; pfam02687
213810005008	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
213810005009	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810005010	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
213810005011	Walker A/P-loop; other site
213810005012	ATP binding site [chemical binding]; other site
213810005013	Q-loop/lid; other site
213810005014	ABC transporter signature motif; other site
213810005015	Walker B; other site
213810005016	D-loop; other site
213810005017	H-loop/switch region; other site
213810005018	Double zinc ribbon; Region: DZR; pfam12773
213810005019	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810005020	6-phosphofructokinase; Provisional; Region: PRK14072
213810005021	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
213810005022	active site
213810005023	ADP/pyrophosphate binding site [chemical binding]; other site
213810005024	dimerization interface [polypeptide binding]; other site
213810005025	allosteric effector site; other site
213810005026	fructose-1,6-bisphosphate binding site; other site
213810005027	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
213810005028	Cation efflux family; Region: Cation_efflux; pfam01545
213810005029	Domain of unknown function (DUF303); Region: DUF303; pfam03629
213810005030	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005031	Transcriptional regulator [Transcription]; Region: LytR; COG1316
213810005032	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
213810005033	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
213810005034	putative active site [active]
213810005035	catalytic site [active]
213810005036	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
213810005037	putative active site [active]
213810005038	catalytic site [active]
213810005039	TfoX N-terminal domain; Region: TfoX_N; pfam04993
213810005040	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
213810005041	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
213810005042	ligand binding site [chemical binding]; other site
213810005043	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
213810005044	4Fe-4S binding domain; Region: Fer4_6; pfam12837
213810005045	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
213810005046	HD domain; Region: HD_3; pfam13023
213810005047	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
213810005048	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810005049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810005050	Walker A/P-loop; other site
213810005051	ATP binding site [chemical binding]; other site
213810005052	Q-loop/lid; other site
213810005053	ABC transporter signature motif; other site
213810005054	Walker B; other site
213810005055	D-loop; other site
213810005056	H-loop/switch region; other site
213810005057	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
213810005058	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810005059	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
213810005060	Walker A/P-loop; other site
213810005061	ATP binding site [chemical binding]; other site
213810005062	Q-loop/lid; other site
213810005063	ABC transporter signature motif; other site
213810005064	Walker B; other site
213810005065	D-loop; other site
213810005066	H-loop/switch region; other site
213810005067	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
213810005068	active site
213810005069	catalytic triad [active]
213810005070	oxyanion hole [active]
213810005071	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
213810005072	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
213810005073	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
213810005074	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
213810005075	TPP-binding site [chemical binding]; other site
213810005076	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810005077	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
213810005078	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
213810005079	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
213810005080	CoA binding domain; Region: CoA_binding; pfam02629
213810005081	isocitrate dehydrogenase; Validated; Region: PRK08299
213810005082	aconitate hydratase; Validated; Region: PRK07229
213810005083	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
213810005084	substrate binding site [chemical binding]; other site
213810005085	ligand binding site [chemical binding]; other site
213810005086	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
213810005087	substrate binding site [chemical binding]; other site
213810005088	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
213810005089	anti sigma factor interaction site; other site
213810005090	regulatory phosphorylation site [posttranslational modification]; other site
213810005091	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
213810005092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810005093	ATP binding site [chemical binding]; other site
213810005094	Mg2+ binding site [ion binding]; other site
213810005095	G-X-G motif; other site
213810005096	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
213810005097	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
213810005098	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
213810005099	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810005100	DNA binding residues [nucleotide binding]
213810005101	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
213810005102	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
213810005103	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
213810005104	active site
213810005105	Double zinc ribbon; Region: DZR; pfam12773
213810005106	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
213810005107	ACT domain-containing protein [General function prediction only]; Region: COG4747
213810005108	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
213810005109	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
213810005110	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810005111	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
213810005112	acyl-activating enzyme (AAE) consensus motif; other site
213810005113	AMP binding site [chemical binding]; other site
213810005114	active site
213810005115	CoA binding site [chemical binding]; other site
213810005116	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
213810005117	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
213810005118	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
213810005119	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
213810005120	dimer interface [polypeptide binding]; other site
213810005121	PYR/PP interface [polypeptide binding]; other site
213810005122	TPP binding site [chemical binding]; other site
213810005123	substrate binding site [chemical binding]; other site
213810005124	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
213810005125	TPP-binding site; other site
213810005126	4Fe-4S binding domain; Region: Fer4; pfam00037
213810005127	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
213810005128	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
213810005129	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
213810005130	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
213810005131	dimer interface [polypeptide binding]; other site
213810005132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810005133	catalytic residue [active]
213810005134	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
213810005135	active site
213810005136	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810005137	dimerization interface [polypeptide binding]; other site
213810005138	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
213810005139	ligand binding site [chemical binding]; other site
213810005140	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810005141	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810005142	metal binding site [ion binding]; metal-binding site
213810005143	active site
213810005144	I-site; other site
213810005145	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
213810005146	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810005147	ligand binding site [chemical binding]; other site
213810005148	dimerization interface [polypeptide binding]; other site
213810005149	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810005150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810005151	metal binding site [ion binding]; metal-binding site
213810005152	active site
213810005153	I-site; other site
213810005154	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
213810005155	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
213810005156	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
213810005157	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
213810005158	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
213810005159	classical (c) SDRs; Region: SDR_c; cd05233
213810005160	NAD(P) binding site [chemical binding]; other site
213810005161	active site
213810005162	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
213810005163	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
213810005164	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
213810005165	homodimer interface [polypeptide binding]; other site
213810005166	NADP binding site [chemical binding]; other site
213810005167	substrate binding site [chemical binding]; other site
213810005168	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
213810005169	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
213810005170	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
213810005171	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
213810005172	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
213810005173	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
213810005174	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
213810005175	V-type ATP synthase subunit I; Validated; Region: PRK05771
213810005176	ATP synthase subunit C; Region: ATP-synt_C; cl00466
213810005177	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
213810005178	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
213810005179	V-type ATP synthase subunit B; Provisional; Region: PRK04196
213810005180	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
213810005181	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
213810005182	Walker A motif homologous position; other site
213810005183	Walker B motif; other site
213810005184	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
213810005185	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
213810005186	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
213810005187	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
213810005188	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810005189	catalytic residue [active]
213810005190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
213810005191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
213810005192	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
213810005193	dimerization interface [polypeptide binding]; other site
213810005194	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
213810005195	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
213810005196	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
213810005197	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
213810005198	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
213810005199	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
213810005200	active site turn [active]
213810005201	phosphorylation site [posttranslational modification]
213810005202	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
213810005203	HPr interaction site; other site
213810005204	glycerol kinase (GK) interaction site [polypeptide binding]; other site
213810005205	active site
213810005206	phosphorylation site [posttranslational modification]
213810005207	putative carbohydrate kinase; Provisional; Region: PRK10565
213810005208	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
213810005209	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
213810005210	putative substrate binding site [chemical binding]; other site
213810005211	putative ATP binding site [chemical binding]; other site
213810005212	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
213810005213	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
213810005214	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
213810005215	dimer interface [polypeptide binding]; other site
213810005216	motif 1; other site
213810005217	active site
213810005218	motif 2; other site
213810005219	motif 3; other site
213810005220	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
213810005221	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
213810005222	putative tRNA-binding site [nucleotide binding]; other site
213810005223	B3/4 domain; Region: B3_4; pfam03483
213810005224	tRNA synthetase B5 domain; Region: B5; smart00874
213810005225	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
213810005226	dimer interface [polypeptide binding]; other site
213810005227	motif 1; other site
213810005228	motif 3; other site
213810005229	motif 2; other site
213810005230	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
213810005231	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810005232	Double zinc ribbon; Region: DZR; pfam12773
213810005233	Predicted membrane protein [Function unknown]; Region: COG2510
213810005234	Predicted membrane protein [Function unknown]; Region: COG2510
213810005235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
213810005236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
213810005237	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
213810005238	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810005239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810005240	Walker A/P-loop; other site
213810005241	ATP binding site [chemical binding]; other site
213810005242	Q-loop/lid; other site
213810005243	ABC transporter signature motif; other site
213810005244	Walker B; other site
213810005245	D-loop; other site
213810005246	H-loop/switch region; other site
213810005247	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
213810005248	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
213810005249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
213810005250	Walker A/P-loop; other site
213810005251	ATP binding site [chemical binding]; other site
213810005252	Q-loop/lid; other site
213810005253	ABC transporter signature motif; other site
213810005254	Walker B; other site
213810005255	D-loop; other site
213810005256	H-loop/switch region; other site
213810005257	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
213810005258	elongation factor G; Reviewed; Region: PRK12740
213810005259	G1 box; other site
213810005260	putative GEF interaction site [polypeptide binding]; other site
213810005261	GTP/Mg2+ binding site [chemical binding]; other site
213810005262	Switch I region; other site
213810005263	G2 box; other site
213810005264	G3 box; other site
213810005265	Switch II region; other site
213810005266	G4 box; other site
213810005267	G5 box; other site
213810005268	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
213810005269	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
213810005270	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
213810005271	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
213810005272	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
213810005273	Peptidase family M23; Region: Peptidase_M23; pfam01551
213810005274	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
213810005275	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
213810005276	active site
213810005277	metal binding site [ion binding]; metal-binding site
213810005278	Uncharacterized conserved protein [Function unknown]; Region: COG0398
213810005279	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
213810005280	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
213810005281	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
213810005282	active site
213810005283	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
213810005284	TSCPD domain; Region: TSCPD; cl14834
213810005285	Uncharacterized conserved protein [Function unknown]; Region: COG1434
213810005286	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
213810005287	putative active site [active]
213810005288	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
213810005289	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
213810005290	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
213810005291	active site
213810005292	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
213810005293	Fic family protein [Function unknown]; Region: COG3177
213810005294	Fic/DOC family; Region: Fic; pfam02661
213810005295	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
213810005296	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
213810005297	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
213810005298	dimer interface [polypeptide binding]; other site
213810005299	ssDNA binding site [nucleotide binding]; other site
213810005300	tetramer (dimer of dimers) interface [polypeptide binding]; other site
213810005301	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
213810005302	Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143
213810005303	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810005304	active site
213810005305	HIGH motif; other site
213810005306	nucleotide binding site [chemical binding]; other site
213810005307	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
213810005308	KMSKS motif; other site
213810005309	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
213810005310	tRNA binding surface [nucleotide binding]; other site
213810005311	anticodon binding site; other site
213810005312	Predicted integral membrane protein [Function unknown]; Region: COG5542
213810005313	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
213810005314	Helix-turn-helix domain; Region: HTH_17; pfam12728
213810005315	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
213810005316	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
213810005317	Domain of unknown function DUF21; Region: DUF21; pfam01595
213810005318	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
213810005319	Transporter associated domain; Region: CorC_HlyC; pfam03471
213810005320	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
213810005321	PHP domain; Region: PHP; pfam02811
213810005322	active site
213810005323	PHP-associated; Region: PHP_C; pfam13263
213810005324	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
213810005325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810005326	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810005327	ABC transporter; Region: ABC_tran_2; pfam12848
213810005328	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
213810005329	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
213810005330	active site
213810005331	catalytic triad [active]
213810005332	oxyanion hole [active]
213810005333	Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548
213810005334	dockerin binding interface; other site
213810005335	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
213810005336	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
213810005337	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
213810005338	pyruvate kinase; Provisional; Region: PRK05826
213810005339	domain interfaces; other site
213810005340	active site
213810005341	Phosphopantetheine attachment site; Region: PP-binding; cl09936
213810005342	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
213810005343	substrate binding site [chemical binding]; other site
213810005344	oxyanion hole (OAH) forming residues; other site
213810005345	trimer interface [polypeptide binding]; other site
213810005346	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
213810005347	active site
213810005348	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
213810005349	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
213810005350	substrate binding site [chemical binding]; other site
213810005351	oxyanion hole (OAH) forming residues; other site
213810005352	trimer interface [polypeptide binding]; other site
213810005353	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
213810005354	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
213810005355	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
213810005356	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
213810005357	dimer interface [polypeptide binding]; other site
213810005358	active site
213810005359	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
213810005360	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
213810005361	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
213810005362	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
213810005363	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
213810005364	acyl-activating enzyme (AAE) consensus motif; other site
213810005365	AMP binding site [chemical binding]; other site
213810005366	active site
213810005367	CoA binding site [chemical binding]; other site
213810005368	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
213810005369	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
213810005370	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
213810005371	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
213810005372	dimer interface [polypeptide binding]; other site
213810005373	PYR/PP interface [polypeptide binding]; other site
213810005374	TPP binding site [chemical binding]; other site
213810005375	substrate binding site [chemical binding]; other site
213810005376	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
213810005377	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
213810005378	Domain of unknown function; Region: EKR; cl11037
213810005379	4Fe-4S binding domain; Region: Fer4_6; pfam12837
213810005380	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
213810005381	TPP-binding site [chemical binding]; other site
213810005382	dimer interface [polypeptide binding]; other site
213810005383	Cohesin domain; Region: Cohesin; pfam00963
213810005384	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
213810005385	substrate binding site; other site
213810005386	dimerization interface; other site
213810005387	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
213810005388	LytB protein; Region: LYTB; cl00507
213810005389	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
213810005390	RNA binding site [nucleotide binding]; other site
213810005391	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
213810005392	RNA binding site [nucleotide binding]; other site
213810005393	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
213810005394	RNA binding site [nucleotide binding]; other site
213810005395	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
213810005396	RNA binding site [nucleotide binding]; other site
213810005397	domain interface; other site
213810005398	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
213810005399	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
213810005400	putative acyl-acceptor binding pocket; other site
213810005401	cytidylate kinase; Provisional; Region: cmk; PRK00023
213810005402	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
213810005403	CMP-binding site; other site
213810005404	The sites determining sugar specificity; other site
213810005405	flavoprotein, HI0933 family; Region: TIGR00275
213810005406	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
213810005407	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
213810005408	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
213810005409	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
213810005410	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
213810005411	Bacitracin resistance protein BacA; Region: BacA; pfam02673
213810005412	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
213810005413	active site
213810005414	Domain of unknown function (DUF377); Region: DUF377; pfam04041
213810005415	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
213810005416	active site
213810005417	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
213810005418	putative metal binding site [ion binding]; other site
213810005419	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
213810005420	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
213810005421	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
213810005422	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
213810005423	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
213810005424	substrate binding pocket [chemical binding]; other site
213810005425	dimer interface [polypeptide binding]; other site
213810005426	inhibitor binding site; inhibition site
213810005427	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
213810005428	B12 binding site [chemical binding]; other site
213810005429	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
213810005430	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
213810005431	ligand binding site [chemical binding]; other site
213810005432	active site
213810005433	UGI interface [polypeptide binding]; other site
213810005434	catalytic site [active]
213810005435	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
213810005436	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
213810005437	Cl binding site [ion binding]; other site
213810005438	oligomer interface [polypeptide binding]; other site
213810005439	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
213810005440	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
213810005441	homodimer interface [polypeptide binding]; other site
213810005442	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
213810005443	active site pocket [active]
213810005444	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
213810005445	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
213810005446	catalytic domain interface [polypeptide binding]; other site
213810005447	putative homodimer interface [polypeptide binding]; other site
213810005448	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
213810005449	recombination protein RecR; Reviewed; Region: recR; PRK00076
213810005450	RecR protein; Region: RecR; pfam02132
213810005451	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
213810005452	putative active site [active]
213810005453	putative metal-binding site [ion binding]; other site
213810005454	tetramer interface [polypeptide binding]; other site
213810005455	hypothetical protein; Validated; Region: PRK00153
213810005456	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
213810005457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
213810005458	Walker A motif; other site
213810005459	ATP binding site [chemical binding]; other site
213810005460	Walker B motif; other site
213810005461	arginine finger; other site
213810005462	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
213810005463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
213810005464	binding surface
213810005465	TPR motif; other site
213810005466	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
213810005467	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
213810005468	Predicted permeases [General function prediction only]; Region: COG0679
213810005469	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
213810005470	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
213810005471	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
213810005472	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
213810005473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
213810005474	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
213810005475	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
213810005476	active site
213810005477	catalytic site [active]
213810005478	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
213810005479	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
213810005480	endonuclease subunit; Provisional; Region: 46; PHA02562
213810005481	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
213810005482	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
213810005483	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
213810005484	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
213810005485	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
213810005486	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
213810005487	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
213810005488	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
213810005489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810005490	FeS/SAM binding site; other site
213810005491	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
213810005492	active site
213810005493	substrate-binding site [chemical binding]; other site
213810005494	metal-binding site [ion binding]
213810005495	GTP binding site [chemical binding]; other site
213810005496	Rubrerythrin [Energy production and conversion]; Region: COG1592
213810005497	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
213810005498	iron binding site [ion binding]; other site
213810005499	Rubrerythrin [Energy production and conversion]; Region: COG1592
213810005500	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
213810005501	diiron binding motif [ion binding]; other site
213810005502	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
213810005503	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
213810005504	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
213810005505	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
213810005506	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
213810005507	DNA polymerase III subunit delta'; Validated; Region: PRK08485
213810005508	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
213810005509	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
213810005510	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
213810005511	catalytic residue [active]
213810005512	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
213810005513	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
213810005514	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
213810005515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
213810005516	DNA binding residues [nucleotide binding]
213810005517	heat shock protein 90; Provisional; Region: PRK05218
213810005518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
213810005519	ATP binding site [chemical binding]; other site
213810005520	Mg2+ binding site [ion binding]; other site
213810005521	G-X-G motif; other site
213810005522	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
213810005523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810005524	dimer interface [polypeptide binding]; other site
213810005525	conserved gate region; other site
213810005526	putative PBP binding loops; other site
213810005527	ABC-ATPase subunit interface; other site
213810005528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
213810005529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810005530	dimer interface [polypeptide binding]; other site
213810005531	ABC-ATPase subunit interface; other site
213810005532	putative PBP binding loops; other site
213810005533	Yip1 domain; Region: Yip1; pfam04893
213810005534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
213810005535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
213810005536	dimer interface [polypeptide binding]; other site
213810005537	conserved gate region; other site
213810005538	ABC-ATPase subunit interface; other site
213810005539	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
213810005540	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
213810005541	FeS/SAM binding site; other site
213810005542	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
213810005543	ATP cone domain; Region: ATP-cone; pfam03477
213810005544	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
213810005545	Class III ribonucleotide reductase; Region: RNR_III; cd01675
213810005546	active site
213810005547	Zn binding site [ion binding]; other site
213810005548	glycine loop; other site
213810005549	Predicted transcriptional regulator [Transcription]; Region: COG1959
213810005550	Transcriptional regulator; Region: Rrf2; pfam02082
213810005551	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
213810005552	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
213810005553	Ligand Binding Site [chemical binding]; other site
213810005554	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
213810005555	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
213810005556	Ligand binding site; other site
213810005557	Putative Catalytic site; other site
213810005558	DXD motif; other site
213810005559	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
213810005560	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
213810005561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
213810005562	ATP binding site [chemical binding]; other site
213810005563	putative Mg++ binding site [ion binding]; other site
213810005564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
213810005565	nucleotide binding region [chemical binding]; other site
213810005566	ATP-binding site [chemical binding]; other site
213810005567	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
213810005568	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
213810005569	putative active site [active]
213810005570	catalytic residue [active]
213810005571	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
213810005572	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
213810005573	Substrate binding site; other site
213810005574	Mg++ binding site; other site
213810005575	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
213810005576	active site
213810005577	substrate binding site [chemical binding]; other site
213810005578	CoA binding site [chemical binding]; other site
213810005579	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
213810005580	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
213810005581	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
213810005582	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
213810005583	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
213810005584	active site
213810005585	glutamate dehydrogenase; Provisional; Region: PRK09414
213810005586	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
213810005587	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
213810005588	NAD(P) binding site [chemical binding]; other site
213810005589	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
213810005590	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810005591	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
213810005592	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
213810005593	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
213810005594	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810005595	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
213810005596	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
213810005597	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
213810005598	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
213810005599	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
213810005600	active site
213810005601	HIGH motif; other site
213810005602	KMSKS motif; other site
213810005603	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
213810005604	tRNA binding surface [nucleotide binding]; other site
213810005605	anticodon binding site; other site
213810005606	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
213810005607	dimer interface [polypeptide binding]; other site
213810005608	putative tRNA-binding site [nucleotide binding]; other site
213810005609	Flavin Reductases; Region: FlaRed; cl00801
213810005610	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
213810005611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
213810005612	active site
213810005613	phosphorylation site [posttranslational modification]
213810005614	intermolecular recognition site; other site
213810005615	dimerization interface [polypeptide binding]; other site
213810005616	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
213810005617	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
213810005618	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
213810005619	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
213810005620	dimerization domain swap beta strand [polypeptide binding]; other site
213810005621	regulatory protein interface [polypeptide binding]; other site
213810005622	active site
213810005623	regulatory phosphorylation site [posttranslational modification]; other site
213810005624	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
213810005625	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
213810005626	RimM N-terminal domain; Region: RimM; pfam01782
213810005627	PRC-barrel domain; Region: PRC; pfam05239
213810005628	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
213810005629	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
213810005630	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
213810005631	signal recognition particle protein; Provisional; Region: PRK10867
213810005632	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
213810005633	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
213810005634	P loop; other site
213810005635	GTP binding site [chemical binding]; other site
213810005636	Signal peptide binding domain; Region: SRP_SPB; pfam02978
213810005637	putative DNA-binding protein; Validated; Region: PRK00118
213810005638	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
213810005639	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
213810005640	homodimer interface [polypeptide binding]; other site
213810005641	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
213810005642	active site pocket [active]
213810005643	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005644	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005645	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005646	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005647	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
213810005648	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
213810005649	Domain of unknown function DUF20; Region: UPF0118; pfam01594
213810005650	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
213810005651	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
213810005652	catalytic domain interface [polypeptide binding]; other site
213810005653	homodimer interface [polypeptide binding]; other site
213810005654	putative active site [active]
213810005655	Predicted membrane protein [Function unknown]; Region: COG4905
213810005656	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
213810005657	Germination protease; Region: Peptidase_A25; cl04057
213810005658	SpoVA protein; Region: SpoVA; cl04298
213810005659	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
213810005660	Fic/DOC family; Region: Fic; cl00960
213810005661	argininosuccinate synthase; Provisional; Region: PRK13820
213810005662	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
213810005663	ANP binding site [chemical binding]; other site
213810005664	Substrate Binding Site II [chemical binding]; other site
213810005665	Substrate Binding Site I [chemical binding]; other site
213810005666	argininosuccinate lyase; Provisional; Region: PRK00855
213810005667	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
213810005668	active sites [active]
213810005669	tetramer interface [polypeptide binding]; other site
213810005670	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
213810005671	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
213810005672	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
213810005673	heterotetramer interface [polypeptide binding]; other site
213810005674	active site pocket [active]
213810005675	cleavage site
213810005676	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
213810005677	feedback inhibition sensing region; other site
213810005678	homohexameric interface [polypeptide binding]; other site
213810005679	nucleotide binding site [chemical binding]; other site
213810005680	N-acetyl-L-glutamate binding site [chemical binding]; other site
213810005681	acetylornithine aminotransferase; Provisional; Region: PRK02627
213810005682	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
213810005683	inhibitor-cofactor binding pocket; inhibition site
213810005684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
213810005685	catalytic residue [active]
213810005686	ornithine carbamoyltransferase; Provisional; Region: PRK00779
213810005687	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
213810005688	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
213810005689	acyl carrier protein; Provisional; Region: acpP; PRK00982
213810005690	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
213810005691	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
213810005692	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
213810005693	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
213810005694	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
213810005695	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
213810005696	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
213810005697	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
213810005698	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
213810005699	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
213810005700	carboxyltransferase (CT) interaction site; other site
213810005701	biotinylation site [posttranslational modification]; other site
213810005702	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
213810005703	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
213810005704	dimer interface [polypeptide binding]; other site
213810005705	active site
213810005706	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
213810005707	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
213810005708	NAD(P) binding site [chemical binding]; other site
213810005709	homotetramer interface [polypeptide binding]; other site
213810005710	homodimer interface [polypeptide binding]; other site
213810005711	active site
213810005712	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
213810005713	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
213810005714	FMN binding site [chemical binding]; other site
213810005715	substrate binding site [chemical binding]; other site
213810005716	putative catalytic residue [active]
213810005717	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
213810005718	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
213810005719	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
213810005720	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
213810005721	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
213810005722	shikimate binding site; other site
213810005723	NAD(P) binding site [chemical binding]; other site
213810005724	shikimate kinase; Reviewed; Region: aroK; PRK00131
213810005725	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
213810005726	ADP binding site [chemical binding]; other site
213810005727	magnesium binding site [ion binding]; other site
213810005728	putative shikimate binding site; other site
213810005729	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
213810005730	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
213810005731	active site
213810005732	HEPN domain; Region: HEPN; pfam05168
213810005733	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
213810005734	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
213810005735	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
213810005736	HflX GTPase family; Region: HflX; cd01878
213810005737	G1 box; other site
213810005738	GTP/Mg2+ binding site [chemical binding]; other site
213810005739	Switch I region; other site
213810005740	G2 box; other site
213810005741	G3 box; other site
213810005742	Switch II region; other site
213810005743	G4 box; other site
213810005744	G5 box; other site
213810005745	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
213810005746	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
213810005747	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
213810005748	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
213810005749	Transcriptional regulators [Transcription]; Region: PurR; COG1609
213810005750	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
213810005751	dimerization interface [polypeptide binding]; other site
213810005752	ligand binding site [chemical binding]; other site
213810005753	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
213810005754	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
213810005755	metal binding site [ion binding]; metal-binding site
213810005756	active site
213810005757	I-site; other site
213810005758	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
213810005759	active site
213810005760	putative catalytic site [active]
213810005761	DNA binding site [nucleotide binding]
213810005762	putative phosphate binding site [ion binding]; other site
213810005763	metal binding site A [ion binding]; metal-binding site
213810005764	AP binding site [nucleotide binding]; other site
213810005765	metal binding site B [ion binding]; metal-binding site
213810005766	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
213810005767	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
213810005768	active site
213810005769	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
213810005770	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
213810005771	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
213810005772	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
213810005773	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
213810005774	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
213810005775	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
213810005776	active site
213810005777	dimer interface [polypeptide binding]; other site
213810005778	motif 1; other site
213810005779	motif 2; other site
213810005780	motif 3; other site
213810005781	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
213810005782	anticodon binding site; other site
213810005783	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
213810005784	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
213810005785	dimer interface [polypeptide binding]; other site
213810005786	anticodon binding site; other site
213810005787	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
213810005788	motif 1; other site
213810005789	dimer interface [polypeptide binding]; other site
213810005790	active site
213810005791	motif 2; other site
213810005792	GAD domain; Region: GAD; pfam02938
213810005793	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
213810005794	active site
213810005795	motif 3; other site
213810005796	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
213810005797	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
213810005798	GatB domain; Region: GatB_Yqey; smart00845
213810005799	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
213810005800	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
213810005801	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
213810005802	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
213810005803	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
213810005804	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
213810005805	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
213810005806	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
213810005807	active site
213810005808	catalytic site [active]
213810005809	Competence-damaged protein; Region: CinA; pfam02464
213810005810	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
213810005811	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
213810005812	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
213810005813	Ligand Binding Site [chemical binding]; other site
213810005814	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
213810005815	non-specific DNA binding site [nucleotide binding]; other site
213810005816	salt bridge; other site
213810005817	sequence-specific DNA binding site [nucleotide binding]; other site
213810005818	CAAX protease self-immunity; Region: Abi; pfam02517
213810005819	Stage II sporulation protein; Region: SpoIID; pfam08486
213810005820	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
213810005821	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005822	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
213810005823	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005824	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005825	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005826	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
213810005827	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
213810005829	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
213810005830	NAD(P) binding site [chemical binding]; other site
213810005831	active site
213810005832	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
213810005833	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
213810005834	endoglucanase; Region: PLN02420
213810005835	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
213810005836	Cellulose binding domain; Region: CBM_3; smart01067
213810005837	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
213810005838	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
213810005839	Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548
213810005840	dockerin binding interface; other site
213810005841	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
213810005842	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
213810005843	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
213810005844	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
213810005845	Cupin domain; Region: Cupin_2; pfam07883
213810005846	Rrf2 family protein; Region: rrf2_super; TIGR00738
213810005847	Transcriptional regulator; Region: Rrf2; pfam02082