-- dump date 20140620_042252 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471857000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471857000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857000003 Walker A motif; other site 471857000004 ATP binding site [chemical binding]; other site 471857000005 Walker B motif; other site 471857000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471857000007 DnaA box-binding interface [nucleotide binding]; other site 471857000008 DNA polymerase III subunit beta; Validated; Region: PRK07761 471857000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471857000010 putative DNA binding surface [nucleotide binding]; other site 471857000011 dimer interface [polypeptide binding]; other site 471857000012 beta-clamp/clamp loader binding surface; other site 471857000013 beta-clamp/translesion DNA polymerase binding surface; other site 471857000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471857000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 471857000016 recombination protein F; Reviewed; Region: recF; PRK00064 471857000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 471857000018 Walker A/P-loop; other site 471857000019 ATP binding site [chemical binding]; other site 471857000020 Q-loop/lid; other site 471857000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857000022 ABC transporter signature motif; other site 471857000023 Walker B; other site 471857000024 D-loop; other site 471857000025 H-loop/switch region; other site 471857000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 471857000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471857000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471857000029 anchoring element; other site 471857000030 dimer interface [polypeptide binding]; other site 471857000031 ATP binding site [chemical binding]; other site 471857000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471857000033 active site 471857000034 putative metal-binding site [ion binding]; other site 471857000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471857000036 DNA gyrase subunit A; Validated; Region: PRK05560 471857000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471857000038 CAP-like domain; other site 471857000039 active site 471857000040 primary dimer interface [polypeptide binding]; other site 471857000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471857000048 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471857000049 active site 471857000050 NTP binding site [chemical binding]; other site 471857000051 metal binding triad [ion binding]; metal-binding site 471857000052 antibiotic binding site [chemical binding]; other site 471857000053 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471857000054 nudix motif; other site 471857000055 Predicted membrane protein [Function unknown]; Region: COG2311 471857000056 Protein of unknown function (DUF418); Region: DUF418; pfam04235 471857000057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857000059 active site 471857000060 phosphorylation site [posttranslational modification] 471857000061 intermolecular recognition site; other site 471857000062 dimerization interface [polypeptide binding]; other site 471857000063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857000064 DNA binding residues [nucleotide binding] 471857000065 dimerization interface [polypeptide binding]; other site 471857000066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857000067 Histidine kinase; Region: HisKA_3; pfam07730 471857000068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000069 ATP binding site [chemical binding]; other site 471857000070 Mg2+ binding site [ion binding]; other site 471857000071 G-X-G motif; other site 471857000072 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 471857000073 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471857000074 active site 471857000075 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 471857000076 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857000077 putative septation inhibitor protein; Reviewed; Region: PRK00159 471857000078 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471857000079 active site 471857000080 catalytic site [active] 471857000081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857000082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857000084 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857000085 Walker A/P-loop; other site 471857000086 ATP binding site [chemical binding]; other site 471857000087 Q-loop/lid; other site 471857000088 ABC transporter signature motif; other site 471857000089 Walker B; other site 471857000090 D-loop; other site 471857000091 H-loop/switch region; other site 471857000092 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471857000093 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857000094 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471857000095 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471857000096 glutamine binding [chemical binding]; other site 471857000097 catalytic triad [active] 471857000098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857000099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857000100 active site 471857000101 ATP binding site [chemical binding]; other site 471857000102 substrate binding site [chemical binding]; other site 471857000103 activation loop (A-loop); other site 471857000104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 471857000105 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857000106 PASTA domain; Region: PASTA; smart00740 471857000107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857000108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857000109 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857000110 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857000111 active site 471857000112 ATP binding site [chemical binding]; other site 471857000113 substrate binding site [chemical binding]; other site 471857000114 activation loop (A-loop); other site 471857000115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471857000116 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471857000117 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 471857000118 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857000119 active site 471857000120 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471857000121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857000122 phosphopeptide binding site; other site 471857000123 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471857000124 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471857000125 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857000126 phosphopeptide binding site; other site 471857000127 TQXA domain; Region: TQXA_dom; TIGR03934 471857000128 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 471857000129 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857000130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857000131 AAA domain; Region: AAA_22; pfam13401 471857000132 Walker A motif; other site 471857000133 ATP binding site [chemical binding]; other site 471857000134 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471857000135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471857000136 binding surface 471857000137 TPR motif; other site 471857000138 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 471857000139 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000140 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 471857000141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000142 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471857000143 NAD(P) binding site [chemical binding]; other site 471857000144 active site 471857000145 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471857000146 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000147 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471857000148 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471857000149 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 471857000150 dimer interface [polypeptide binding]; other site 471857000151 active site 471857000152 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857000153 substrate binding site [chemical binding]; other site 471857000154 catalytic residue [active] 471857000155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857000156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857000158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000159 non-specific DNA binding site [nucleotide binding]; other site 471857000160 salt bridge; other site 471857000161 sequence-specific DNA binding site [nucleotide binding]; other site 471857000162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471857000163 TPR motif; other site 471857000164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857000165 binding surface 471857000166 active site 471857000167 ATP binding site [chemical binding]; other site 471857000168 Phosphotransferase enzyme family; Region: APH; pfam01636 471857000169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471857000170 Copper resistance protein D; Region: CopD; cl00563 471857000171 Copper resistance protein D; Region: CopD; pfam05425 471857000172 BCCT family transporter; Region: BCCT; pfam02028 471857000173 CopC domain; Region: CopC; pfam04234 471857000174 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 471857000175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857000176 putative PBP binding loops; other site 471857000177 dimer interface [polypeptide binding]; other site 471857000178 ABC-ATPase subunit interface; other site 471857000179 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471857000180 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 471857000181 Walker A/P-loop; other site 471857000182 ATP binding site [chemical binding]; other site 471857000183 Q-loop/lid; other site 471857000184 ABC transporter signature motif; other site 471857000185 Walker B; other site 471857000186 D-loop; other site 471857000187 H-loop/switch region; other site 471857000188 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471857000189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857000190 dimer interface [polypeptide binding]; other site 471857000191 conserved gate region; other site 471857000192 putative PBP binding loops; other site 471857000193 ABC-ATPase subunit interface; other site 471857000194 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471857000195 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 471857000196 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 471857000197 sorbitol dehydrogenase; Provisional; Region: PRK07067 471857000198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000199 NAD(P) binding site [chemical binding]; other site 471857000200 active site 471857000201 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471857000202 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471857000203 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857000204 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 471857000205 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 471857000206 NADP-binding site; other site 471857000207 homotetramer interface [polypeptide binding]; other site 471857000208 substrate binding site [chemical binding]; other site 471857000209 homodimer interface [polypeptide binding]; other site 471857000210 active site 471857000211 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471857000212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857000213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857000216 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857000217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857000218 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000219 methionine sulfoxide reductase A; Provisional; Region: PRK00058 471857000220 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857000221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000222 Putative zinc-finger; Region: zf-HC2; pfam13490 471857000223 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 471857000224 Histidine kinase; Region: His_kinase; pfam06580 471857000225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000226 ATP binding site [chemical binding]; other site 471857000227 Mg2+ binding site [ion binding]; other site 471857000228 G-X-G motif; other site 471857000229 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 471857000230 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471857000231 tandem repeat interface [polypeptide binding]; other site 471857000232 oligomer interface [polypeptide binding]; other site 471857000233 active site residues [active] 471857000234 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471857000235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857000236 active site 471857000237 phosphorylation site [posttranslational modification] 471857000238 intermolecular recognition site; other site 471857000239 dimerization interface [polypeptide binding]; other site 471857000240 LytTr DNA-binding domain; Region: LytTR; smart00850 471857000241 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857000242 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857000243 Na binding site [ion binding]; other site 471857000244 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857000245 active site residue [active] 471857000246 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 471857000247 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 471857000248 Protein of unknown function (DUF952); Region: DUF952; cl01393 471857000249 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857000250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857000252 DNA binding residues [nucleotide binding] 471857000253 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 471857000254 Ferritin-like domain; Region: Ferritin; pfam00210 471857000255 ferroxidase diiron center [ion binding]; other site 471857000256 arginine deiminase; Provisional; Region: PRK01388 471857000257 CAAX protease self-immunity; Region: Abi; pfam02517 471857000258 BCCT family transporter; Region: BCCT; pfam02028 471857000259 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471857000260 Predicted membrane protein [Function unknown]; Region: COG2119 471857000261 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 471857000262 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471857000263 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471857000264 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471857000265 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471857000266 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471857000267 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471857000268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471857000269 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 471857000270 Walker A/P-loop; other site 471857000271 ATP binding site [chemical binding]; other site 471857000272 Q-loop/lid; other site 471857000273 ABC transporter signature motif; other site 471857000274 Walker B; other site 471857000275 D-loop; other site 471857000276 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 471857000277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857000278 Walker A/P-loop; other site 471857000279 ATP binding site [chemical binding]; other site 471857000280 Q-loop/lid; other site 471857000281 Walker B; other site 471857000282 D-loop; other site 471857000283 H-loop/switch region; other site 471857000284 GAF domain; Region: GAF; pfam01590 471857000285 Histidine kinase; Region: HisKA_3; pfam07730 471857000286 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471857000287 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857000289 active site 471857000290 phosphorylation site [posttranslational modification] 471857000291 intermolecular recognition site; other site 471857000292 dimerization interface [polypeptide binding]; other site 471857000293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857000294 DNA binding residues [nucleotide binding] 471857000295 dimerization interface [polypeptide binding]; other site 471857000296 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 471857000297 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471857000298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857000299 dimer interface [polypeptide binding]; other site 471857000300 conserved gate region; other site 471857000301 putative PBP binding loops; other site 471857000302 ABC-ATPase subunit interface; other site 471857000303 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471857000304 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 471857000305 Walker A/P-loop; other site 471857000306 ATP binding site [chemical binding]; other site 471857000307 Q-loop/lid; other site 471857000308 ABC transporter signature motif; other site 471857000309 Walker B; other site 471857000310 D-loop; other site 471857000311 H-loop/switch region; other site 471857000312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471857000313 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 471857000314 Uncharacterized conserved protein [Function unknown]; Region: COG4715 471857000315 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857000316 AAA ATPase domain; Region: AAA_16; pfam13191 471857000317 AAA domain; Region: AAA_22; pfam13401 471857000318 pantothenate kinase; Provisional; Region: PRK05439 471857000319 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 471857000320 ATP-binding site [chemical binding]; other site 471857000321 CoA-binding site [chemical binding]; other site 471857000322 Mg2+-binding site [ion binding]; other site 471857000323 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471857000324 ADP-ribose binding site [chemical binding]; other site 471857000325 prephenate dehydratase; Provisional; Region: PRK11898 471857000326 Prephenate dehydratase; Region: PDT; pfam00800 471857000327 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471857000328 putative L-Phe binding site [chemical binding]; other site 471857000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857000330 putative substrate translocation pore; other site 471857000331 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 471857000332 Septum formation; Region: Septum_form; pfam13845 471857000333 Septum formation; Region: Septum_form; pfam13845 471857000334 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 471857000335 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471857000336 haloalkane dehalogenase; Provisional; Region: PRK00870 471857000337 seryl-tRNA synthetase; Provisional; Region: PRK05431 471857000338 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471857000339 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471857000340 dimer interface [polypeptide binding]; other site 471857000341 active site 471857000342 motif 1; other site 471857000343 motif 2; other site 471857000344 motif 3; other site 471857000345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857000346 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471857000347 active site 471857000348 motif I; other site 471857000349 motif II; other site 471857000350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857000351 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471857000352 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000353 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471857000354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857000355 UDP-galactopyranose mutase; Region: GLF; pfam03275 471857000356 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 471857000357 active site 471857000358 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 471857000359 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 471857000360 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 471857000361 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 471857000362 short chain dehydrogenase; Provisional; Region: PRK07904 471857000363 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471857000364 NAD(P) binding site [chemical binding]; other site 471857000365 active site 471857000366 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857000367 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000368 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471857000369 Predicted membrane protein [Function unknown]; Region: COG2246 471857000370 GtrA-like protein; Region: GtrA; pfam04138 471857000371 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857000372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000373 active site 471857000374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000375 EspG family; Region: ESX-1_EspG; pfam14011 471857000376 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000377 active site 471857000378 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857000379 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471857000380 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 471857000381 Walker A/P-loop; other site 471857000382 ATP binding site [chemical binding]; other site 471857000383 Q-loop/lid; other site 471857000384 ABC transporter signature motif; other site 471857000385 Walker B; other site 471857000386 D-loop; other site 471857000387 H-loop/switch region; other site 471857000388 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 471857000389 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857000390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857000391 pseudaminic acid synthase; Region: PseI; TIGR03586 471857000392 NeuB family; Region: NeuB; pfam03102 471857000393 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 471857000394 NeuB binding interface [polypeptide binding]; other site 471857000395 putative substrate binding site [chemical binding]; other site 471857000396 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471857000397 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857000398 inhibitor-cofactor binding pocket; inhibition site 471857000399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000400 catalytic residue [active] 471857000401 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 471857000402 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 471857000403 NAD(P) binding site [chemical binding]; other site 471857000404 homodimer interface [polypeptide binding]; other site 471857000405 substrate binding site [chemical binding]; other site 471857000406 active site 471857000407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000408 active site 471857000409 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 471857000410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000411 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 471857000412 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857000413 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857000414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857000415 catalytic residue [active] 471857000416 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 471857000417 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471857000418 NAD(P) binding site [chemical binding]; other site 471857000419 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471857000420 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471857000421 PA/protease or protease-like domain interface [polypeptide binding]; other site 471857000422 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 471857000423 Peptidase family M28; Region: Peptidase_M28; pfam04389 471857000424 active site 471857000425 metal binding site [ion binding]; metal-binding site 471857000426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471857000427 MarR family; Region: MarR_2; pfam12802 471857000428 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471857000429 Predicted transcriptional regulator [Transcription]; Region: COG1959 471857000430 Transcriptional regulator; Region: Rrf2; pfam02082 471857000431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000432 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471857000433 NAD(P) binding site [chemical binding]; other site 471857000434 active site 471857000435 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471857000436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857000437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000438 non-specific DNA binding site [nucleotide binding]; other site 471857000439 salt bridge; other site 471857000440 sequence-specific DNA binding site [nucleotide binding]; other site 471857000441 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 471857000442 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471857000443 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471857000444 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 471857000445 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471857000446 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471857000447 dimer interface [polypeptide binding]; other site 471857000448 active site 471857000449 CoA binding pocket [chemical binding]; other site 471857000450 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471857000451 cyclase homology domain; Region: CHD; cd07302 471857000452 nucleotidyl binding site; other site 471857000453 metal binding site [ion binding]; metal-binding site 471857000454 dimer interface [polypeptide binding]; other site 471857000455 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471857000456 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471857000457 putative DNA binding site [nucleotide binding]; other site 471857000458 putative homodimer interface [polypeptide binding]; other site 471857000459 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471857000460 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 471857000461 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 471857000462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857000464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857000465 DNA binding residues [nucleotide binding] 471857000466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000467 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857000468 peptide chain release factor 1; Provisional; Region: PRK04011 471857000469 hypothetical protein; Provisional; Region: PRK10621 471857000470 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471857000471 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 471857000472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000474 homodimer interface [polypeptide binding]; other site 471857000475 catalytic residue [active] 471857000476 Dienelactone hydrolase family; Region: DLH; pfam01738 471857000477 PPE family; Region: PPE; pfam00823 471857000478 EspG family; Region: ESX-1_EspG; pfam14011 471857000479 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471857000480 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 471857000481 acyl-activating enzyme (AAE) consensus motif; other site 471857000482 putative AMP binding site [chemical binding]; other site 471857000483 putative active site [active] 471857000484 putative CoA binding site [chemical binding]; other site 471857000485 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 471857000486 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471857000487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857000488 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857000489 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471857000490 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471857000491 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857000492 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471857000493 inhibitor-cofactor binding pocket; inhibition site 471857000494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000495 catalytic residue [active] 471857000496 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471857000497 nudix motif; other site 471857000498 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 471857000499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857000500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857000501 dimerization interface [polypeptide binding]; other site 471857000502 putative DNA binding site [nucleotide binding]; other site 471857000503 putative Zn2+ binding site [ion binding]; other site 471857000504 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471857000505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857000506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857000507 S-adenosylmethionine binding site [chemical binding]; other site 471857000508 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857000509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000510 non-specific DNA binding site [nucleotide binding]; other site 471857000511 salt bridge; other site 471857000512 sequence-specific DNA binding site [nucleotide binding]; other site 471857000513 Cupin domain; Region: Cupin_2; pfam07883 471857000514 Predicted membrane protein [Function unknown]; Region: COG2323 471857000515 Protein of unknown function DUF262; Region: DUF262; pfam03235 471857000516 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471857000517 Uncharacterized conserved protein [Function unknown]; Region: COG3472 471857000518 Divergent AAA domain; Region: AAA_4; pfam04326 471857000519 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471857000520 active site 471857000521 asparagine synthetase B; Provisional; Region: asnB; PRK09431 471857000522 dimer interface [polypeptide binding]; other site 471857000523 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471857000524 Ligand Binding Site [chemical binding]; other site 471857000525 Molecular Tunnel; other site 471857000526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857000527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000528 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 471857000529 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000530 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471857000531 putative active site [active] 471857000532 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471857000533 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 471857000534 DNA binding residues [nucleotide binding] 471857000535 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 471857000536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857000537 S-adenosylmethionine binding site [chemical binding]; other site 471857000538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857000540 active site 471857000541 phosphorylation site [posttranslational modification] 471857000542 intermolecular recognition site; other site 471857000543 dimerization interface [polypeptide binding]; other site 471857000544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857000545 DNA binding residues [nucleotide binding] 471857000546 dimerization interface [polypeptide binding]; other site 471857000547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857000548 Histidine kinase; Region: HisKA_3; pfam07730 471857000549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000550 ATP binding site [chemical binding]; other site 471857000551 Mg2+ binding site [ion binding]; other site 471857000552 G-X-G motif; other site 471857000553 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857000554 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471857000555 Walker A/P-loop; other site 471857000556 ATP binding site [chemical binding]; other site 471857000557 Q-loop/lid; other site 471857000558 ABC transporter signature motif; other site 471857000559 Walker B; other site 471857000560 D-loop; other site 471857000561 H-loop/switch region; other site 471857000562 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857000563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857000564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000565 ATP binding site [chemical binding]; other site 471857000566 Mg2+ binding site [ion binding]; other site 471857000567 G-X-G motif; other site 471857000568 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857000569 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857000570 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471857000571 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857000572 G1 box; other site 471857000573 GTP/Mg2+ binding site [chemical binding]; other site 471857000574 G2 box; other site 471857000575 Switch I region; other site 471857000576 G3 box; other site 471857000577 Switch II region; other site 471857000578 G4 box; other site 471857000579 G5 box; other site 471857000580 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471857000581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857000582 S-adenosylmethionine binding site [chemical binding]; other site 471857000583 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 471857000584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471857000585 Cysteine-rich domain; Region: CCG; pfam02754 471857000586 Cysteine-rich domain; Region: CCG; pfam02754 471857000587 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 471857000588 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000589 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 471857000590 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000591 Cytochrome P450; Region: p450; cl12078 471857000592 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471857000593 Predicted membrane protein [Function unknown]; Region: COG2364 471857000594 aminotransferase; Validated; Region: PRK07777 471857000595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000597 homodimer interface [polypeptide binding]; other site 471857000598 catalytic residue [active] 471857000599 Protein of unknown function (DUF445); Region: DUF445; pfam04286 471857000600 Predicted transcriptional regulators [Transcription]; Region: COG1695 471857000601 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471857000602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857000603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471857000604 Walker A/P-loop; other site 471857000605 ATP binding site [chemical binding]; other site 471857000606 Q-loop/lid; other site 471857000607 ABC transporter signature motif; other site 471857000608 Walker B; other site 471857000609 D-loop; other site 471857000610 H-loop/switch region; other site 471857000611 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 471857000612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 471857000613 AAA domain; Region: AAA_18; pfam13238 471857000614 Walker A/P-loop; other site 471857000615 ATP binding site [chemical binding]; other site 471857000616 Q-loop/lid; other site 471857000617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000619 non-specific DNA binding site [nucleotide binding]; other site 471857000620 salt bridge; other site 471857000621 sequence-specific DNA binding site [nucleotide binding]; other site 471857000622 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471857000623 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 471857000624 putative deacylase active site [active] 471857000625 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471857000626 hydrophobic ligand binding site; other site 471857000627 Prostaglandin dehydrogenases; Region: PGDH; cd05288 471857000628 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 471857000629 NAD(P) binding site [chemical binding]; other site 471857000630 substrate binding site [chemical binding]; other site 471857000631 dimer interface [polypeptide binding]; other site 471857000632 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 471857000633 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 471857000634 active site 471857000635 substrate binding site [chemical binding]; other site 471857000636 cosubstrate binding site; other site 471857000637 catalytic site [active] 471857000638 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 471857000639 active site 471857000640 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 471857000641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857000642 gall11 coactivator domain; Region: gal11_coact; cd12191 471857000643 heterodimer interface [polypeptide binding]; other site 471857000644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 471857000645 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857000646 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000647 ABC-ATPase subunit interface; other site 471857000648 dimer interface [polypeptide binding]; other site 471857000649 putative PBP binding regions; other site 471857000650 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471857000651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000652 ABC-ATPase subunit interface; other site 471857000653 dimer interface [polypeptide binding]; other site 471857000654 putative PBP binding regions; other site 471857000655 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857000656 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857000657 Walker A/P-loop; other site 471857000658 ATP binding site [chemical binding]; other site 471857000659 Q-loop/lid; other site 471857000660 ABC transporter signature motif; other site 471857000661 Walker B; other site 471857000662 D-loop; other site 471857000663 H-loop/switch region; other site 471857000664 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857000665 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857000666 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857000667 putative active site [active] 471857000668 putative substrate binding site [chemical binding]; other site 471857000669 putative cosubstrate binding site; other site 471857000670 catalytic site [active] 471857000671 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 471857000672 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471857000673 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000674 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471857000675 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471857000676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000677 NAD(P) binding site [chemical binding]; other site 471857000678 active site 471857000679 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857000680 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471857000681 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 471857000682 putative ADP-binding pocket [chemical binding]; other site 471857000683 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 471857000684 ATP P2X receptor; Region: P2X_receptor; cl02993 471857000685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857000686 catalytic core [active] 471857000687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857000688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857000689 dimer interface [polypeptide binding]; other site 471857000690 phosphorylation site [posttranslational modification] 471857000691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000692 ATP binding site [chemical binding]; other site 471857000693 Mg2+ binding site [ion binding]; other site 471857000694 G-X-G motif; other site 471857000695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857000696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857000697 active site 471857000698 phosphorylation site [posttranslational modification] 471857000699 intermolecular recognition site; other site 471857000700 dimerization interface [polypeptide binding]; other site 471857000701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857000702 DNA binding site [nucleotide binding] 471857000703 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471857000704 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857000705 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857000706 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471857000707 AP (apurinic/apyrimidinic) site pocket; other site 471857000708 DNA interaction; other site 471857000709 Metal-binding active site; metal-binding site 471857000710 Proline dehydrogenase; Region: Pro_dh; cl03282 471857000711 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471857000712 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471857000713 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471857000714 DNA binding domain, excisionase family; Region: excise; TIGR01764 471857000715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000716 NAD(P) binding site [chemical binding]; other site 471857000717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857000718 active site 471857000719 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 471857000720 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857000721 putative acyl-acceptor binding pocket; other site 471857000722 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471857000723 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471857000724 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 471857000725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857000727 DNA binding residues [nucleotide binding] 471857000728 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857000729 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857000730 acyl-activating enzyme (AAE) consensus motif; other site 471857000731 AMP binding site [chemical binding]; other site 471857000732 active site 471857000733 CoA binding site [chemical binding]; other site 471857000734 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 471857000735 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 471857000736 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 471857000737 CoA binding domain; Region: CoA_binding; pfam02629 471857000738 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471857000739 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471857000740 tRNA; other site 471857000741 putative tRNA binding site [nucleotide binding]; other site 471857000742 putative NADP binding site [chemical binding]; other site 471857000743 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471857000744 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471857000745 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 471857000746 domain interfaces; other site 471857000747 active site 471857000748 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 471857000749 active site 471857000750 homodimer interface [polypeptide binding]; other site 471857000751 SAM binding site [chemical binding]; other site 471857000752 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 471857000753 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471857000754 active site 471857000755 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 471857000756 dimer interface [polypeptide binding]; other site 471857000757 active site 471857000758 Schiff base residues; other site 471857000759 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471857000760 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857000761 inhibitor-cofactor binding pocket; inhibition site 471857000762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000763 catalytic residue [active] 471857000764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857000765 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471857000766 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471857000767 catalytic residues [active] 471857000768 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471857000769 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471857000770 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471857000771 ResB-like family; Region: ResB; pfam05140 471857000772 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 471857000773 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471857000774 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471857000775 DNA binding residues [nucleotide binding] 471857000776 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471857000777 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 471857000778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857000779 catalytic residue [active] 471857000780 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 471857000781 UbiA prenyltransferase family; Region: UbiA; pfam01040 471857000782 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 471857000783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857000784 acyl-activating enzyme (AAE) consensus motif; other site 471857000785 AMP binding site [chemical binding]; other site 471857000786 active site 471857000787 CoA binding site [chemical binding]; other site 471857000788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857000789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000790 non-specific DNA binding site [nucleotide binding]; other site 471857000791 salt bridge; other site 471857000792 sequence-specific DNA binding site [nucleotide binding]; other site 471857000793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857000794 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471857000795 substrate binding site [chemical binding]; other site 471857000796 oxyanion hole (OAH) forming residues; other site 471857000797 trimer interface [polypeptide binding]; other site 471857000798 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471857000799 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471857000800 dimer interface [polypeptide binding]; other site 471857000801 tetramer interface [polypeptide binding]; other site 471857000802 PYR/PP interface [polypeptide binding]; other site 471857000803 TPP binding site [chemical binding]; other site 471857000804 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471857000805 TPP-binding site; other site 471857000806 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471857000807 Zn binding site [ion binding]; other site 471857000808 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471857000809 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471857000810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857000811 S-adenosylmethionine binding site [chemical binding]; other site 471857000812 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471857000813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857000814 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471857000815 NADH dehydrogenase subunit B; Validated; Region: PRK06411 471857000816 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 471857000817 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 471857000818 NADH dehydrogenase subunit D; Validated; Region: PRK06075 471857000819 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 471857000820 NADH dehydrogenase subunit E; Validated; Region: PRK07539 471857000821 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471857000822 putative dimer interface [polypeptide binding]; other site 471857000823 [2Fe-2S] cluster binding site [ion binding]; other site 471857000824 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471857000825 SLBB domain; Region: SLBB; pfam10531 471857000826 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 471857000827 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471857000828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857000829 catalytic loop [active] 471857000830 iron binding site [ion binding]; other site 471857000831 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471857000832 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471857000833 molybdopterin cofactor binding site; other site 471857000834 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471857000835 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471857000836 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471857000837 4Fe-4S binding domain; Region: Fer4; pfam00037 471857000838 4Fe-4S binding domain; Region: Fer4; pfam00037 471857000839 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471857000840 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471857000841 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471857000842 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471857000843 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471857000844 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857000845 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 471857000846 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857000847 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471857000848 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857000849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471857000850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857000851 substrate binding pocket [chemical binding]; other site 471857000852 chain length determination region; other site 471857000853 substrate-Mg2+ binding site; other site 471857000854 catalytic residues [active] 471857000855 aspartate-rich region 1; other site 471857000856 active site lid residues [active] 471857000857 aspartate-rich region 2; other site 471857000858 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 471857000859 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 471857000860 TPP-binding site [chemical binding]; other site 471857000861 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 471857000862 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 471857000863 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471857000864 dimer interface [polypeptide binding]; other site 471857000865 PYR/PP interface [polypeptide binding]; other site 471857000866 TPP binding site [chemical binding]; other site 471857000867 substrate binding site [chemical binding]; other site 471857000868 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 471857000869 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 471857000870 AsnC family; Region: AsnC_trans_reg; pfam01037 471857000871 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471857000872 Amidinotransferase; Region: Amidinotransf; cl12043 471857000873 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000874 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471857000875 ABC-ATPase subunit interface; other site 471857000876 dimer interface [polypeptide binding]; other site 471857000877 putative PBP binding regions; other site 471857000878 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471857000879 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000880 ABC-ATPase subunit interface; other site 471857000881 dimer interface [polypeptide binding]; other site 471857000882 putative PBP binding regions; other site 471857000883 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857000884 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471857000885 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471857000886 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857000887 intersubunit interface [polypeptide binding]; other site 471857000888 heat shock protein HtpX; Provisional; Region: PRK03072 471857000889 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471857000890 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471857000891 substrate binding site; other site 471857000892 tetramer interface; other site 471857000893 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 471857000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 471857000895 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 471857000896 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471857000897 Amidase; Region: Amidase; cl11426 471857000898 Domain of unknown function (DUF309); Region: DUF309; pfam03745 471857000899 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471857000900 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471857000901 D-pathway; other site 471857000902 Putative ubiquinol binding site [chemical binding]; other site 471857000903 Low-spin heme (heme b) binding site [chemical binding]; other site 471857000904 Putative water exit pathway; other site 471857000905 Binuclear center (heme o3/CuB) [ion binding]; other site 471857000906 K-pathway; other site 471857000907 Putative proton exit pathway; other site 471857000908 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 471857000909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471857000910 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471857000911 GAF domain; Region: GAF_2; pfam13185 471857000912 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471857000913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471857000914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857000915 metal binding site [ion binding]; metal-binding site 471857000916 active site 471857000917 I-site; other site 471857000918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857000919 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 471857000920 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471857000921 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471857000922 active site 471857000923 catalytic site [active] 471857000924 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 471857000925 active site 471857000926 catalytic site [active] 471857000927 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857000928 active site 471857000929 catalytic triad [active] 471857000930 oxyanion hole [active] 471857000931 Predicted transcriptional regulators [Transcription]; Region: COG1725 471857000932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857000933 DNA-binding site [nucleotide binding]; DNA binding site 471857000934 aspartate aminotransferase; Provisional; Region: PRK05764 471857000935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000937 homodimer interface [polypeptide binding]; other site 471857000938 catalytic residue [active] 471857000939 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 471857000940 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471857000941 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471857000942 putative homodimer interface [polypeptide binding]; other site 471857000943 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471857000944 heterodimer interface [polypeptide binding]; other site 471857000945 homodimer interface [polypeptide binding]; other site 471857000946 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471857000947 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471857000948 23S rRNA interface [nucleotide binding]; other site 471857000949 putative thiostrepton binding site; other site 471857000950 L7/L12 interface [polypeptide binding]; other site 471857000951 L25 interface [polypeptide binding]; other site 471857000952 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471857000953 mRNA/rRNA interface [nucleotide binding]; other site 471857000954 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471857000955 23S rRNA interface [nucleotide binding]; other site 471857000956 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471857000957 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471857000958 core dimer interface [polypeptide binding]; other site 471857000959 peripheral dimer interface [polypeptide binding]; other site 471857000960 L10 interface [polypeptide binding]; other site 471857000961 L11 interface [polypeptide binding]; other site 471857000962 putative EF-Tu interaction site [polypeptide binding]; other site 471857000963 putative EF-G interaction site [polypeptide binding]; other site 471857000964 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471857000965 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 471857000966 Walker A/P-loop; other site 471857000967 ATP binding site [chemical binding]; other site 471857000968 Q-loop/lid; other site 471857000969 ABC transporter signature motif; other site 471857000970 Walker B; other site 471857000971 D-loop; other site 471857000972 H-loop/switch region; other site 471857000973 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471857000974 Permease; Region: Permease; pfam02405 471857000975 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471857000976 Permease; Region: Permease; pfam02405 471857000977 mce related protein; Region: MCE; pfam02470 471857000978 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857000979 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000980 mce related protein; Region: MCE; pfam02470 471857000981 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000982 mce related protein; Region: MCE; pfam02470 471857000983 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857000984 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000985 active site 1 [active] 471857000986 mce related protein; Region: MCE; pfam02470 471857000987 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857000988 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000989 mce related protein; Region: MCE; pfam02470 471857000990 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857000991 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000992 mce related protein; Region: MCE; pfam02470 471857000993 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471857000994 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471857000995 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 471857000996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471857000997 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471857000998 RPB10 interaction site [polypeptide binding]; other site 471857000999 RPB1 interaction site [polypeptide binding]; other site 471857001000 RPB11 interaction site [polypeptide binding]; other site 471857001001 RPB3 interaction site [polypeptide binding]; other site 471857001002 RPB12 interaction site [polypeptide binding]; other site 471857001003 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471857001004 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471857001005 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471857001006 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471857001007 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471857001008 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471857001009 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471857001010 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471857001011 DNA binding site [nucleotide binding] 471857001012 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471857001013 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857001014 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857001015 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471857001016 S17 interaction site [polypeptide binding]; other site 471857001017 S8 interaction site; other site 471857001018 16S rRNA interaction site [nucleotide binding]; other site 471857001019 streptomycin interaction site [chemical binding]; other site 471857001020 23S rRNA interaction site [nucleotide binding]; other site 471857001021 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471857001022 30S ribosomal protein S7; Validated; Region: PRK05302 471857001023 elongation factor G; Reviewed; Region: PRK00007 471857001024 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471857001025 G1 box; other site 471857001026 putative GEF interaction site [polypeptide binding]; other site 471857001027 GTP/Mg2+ binding site [chemical binding]; other site 471857001028 Switch I region; other site 471857001029 G2 box; other site 471857001030 G3 box; other site 471857001031 Switch II region; other site 471857001032 G4 box; other site 471857001033 G5 box; other site 471857001034 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471857001035 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471857001036 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471857001037 elongation factor Tu; Reviewed; Region: PRK00049 471857001038 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471857001039 G1 box; other site 471857001040 GEF interaction site [polypeptide binding]; other site 471857001041 GTP/Mg2+ binding site [chemical binding]; other site 471857001042 Switch I region; other site 471857001043 G2 box; other site 471857001044 G3 box; other site 471857001045 Switch II region; other site 471857001046 G4 box; other site 471857001047 G5 box; other site 471857001048 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471857001049 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471857001050 Antibiotic Binding Site [chemical binding]; other site 471857001051 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471857001052 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471857001053 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471857001054 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471857001055 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471857001056 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471857001057 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471857001058 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471857001059 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471857001060 putative translocon binding site; other site 471857001061 protein-rRNA interface [nucleotide binding]; other site 471857001062 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471857001063 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471857001064 G-X-X-G motif; other site 471857001065 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471857001066 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471857001067 23S rRNA interface [nucleotide binding]; other site 471857001068 5S rRNA interface [nucleotide binding]; other site 471857001069 putative antibiotic binding site [chemical binding]; other site 471857001070 L25 interface [polypeptide binding]; other site 471857001071 L27 interface [polypeptide binding]; other site 471857001072 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471857001073 23S rRNA interface [nucleotide binding]; other site 471857001074 putative translocon interaction site; other site 471857001075 signal recognition particle (SRP54) interaction site; other site 471857001076 L23 interface [polypeptide binding]; other site 471857001077 trigger factor interaction site; other site 471857001078 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471857001079 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471857001080 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471857001081 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471857001082 RNA binding site [nucleotide binding]; other site 471857001083 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471857001084 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471857001085 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471857001086 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 471857001087 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471857001088 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471857001089 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471857001090 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471857001091 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471857001092 5S rRNA interface [nucleotide binding]; other site 471857001093 L27 interface [polypeptide binding]; other site 471857001094 23S rRNA interface [nucleotide binding]; other site 471857001095 L5 interface [polypeptide binding]; other site 471857001096 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471857001097 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471857001098 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471857001099 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471857001100 23S rRNA binding site [nucleotide binding]; other site 471857001101 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471857001102 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471857001103 SecY translocase; Region: SecY; pfam00344 471857001104 adenylate kinase; Reviewed; Region: adk; PRK00279 471857001105 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471857001106 AMP-binding site [chemical binding]; other site 471857001107 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471857001108 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471857001109 active site 471857001110 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471857001111 rRNA binding site [nucleotide binding]; other site 471857001112 predicted 30S ribosome binding site; other site 471857001113 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 471857001114 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471857001115 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471857001116 30S ribosomal protein S11; Validated; Region: PRK05309 471857001117 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471857001118 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471857001119 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857001120 RNA binding surface [nucleotide binding]; other site 471857001121 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471857001122 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471857001123 alphaNTD homodimer interface [polypeptide binding]; other site 471857001124 alphaNTD - beta interaction site [polypeptide binding]; other site 471857001125 alphaNTD - beta' interaction site [polypeptide binding]; other site 471857001126 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471857001127 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471857001128 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471857001129 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471857001130 dimerization interface 3.5A [polypeptide binding]; other site 471857001131 active site 471857001132 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471857001133 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 471857001134 putative active site [active] 471857001135 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 471857001136 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 471857001137 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471857001138 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857001139 active site 471857001140 catalytic residues [active] 471857001141 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 471857001142 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 471857001143 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471857001144 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857001145 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471857001146 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857001147 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857001148 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 471857001149 nucleotide binding site [chemical binding]; other site 471857001150 putative NEF/HSP70 interaction site [polypeptide binding]; other site 471857001151 SBD interface [polypeptide binding]; other site 471857001152 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 471857001153 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 471857001154 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 471857001155 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 471857001156 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471857001157 23S rRNA interface [nucleotide binding]; other site 471857001158 L3 interface [polypeptide binding]; other site 471857001159 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471857001160 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471857001161 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471857001162 active site 471857001163 substrate binding site [chemical binding]; other site 471857001164 metal binding site [ion binding]; metal-binding site 471857001165 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471857001166 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 471857001167 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857001168 active site 471857001169 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857001170 chlorophyllase; Region: PLN00021 471857001171 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471857001172 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471857001173 glutaminase active site [active] 471857001174 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857001175 dimer interface [polypeptide binding]; other site 471857001176 active site 471857001177 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857001178 dimer interface [polypeptide binding]; other site 471857001179 active site 471857001180 Uncharacterized conserved protein [Function unknown]; Region: COG0062 471857001181 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471857001182 putative substrate binding site [chemical binding]; other site 471857001183 putative ATP binding site [chemical binding]; other site 471857001184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471857001185 nucleotide binding site [chemical binding]; other site 471857001186 alanine racemase; Reviewed; Region: alr; PRK00053 471857001187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471857001188 active site 471857001189 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857001190 dimer interface [polypeptide binding]; other site 471857001191 substrate binding site [chemical binding]; other site 471857001192 catalytic residues [active] 471857001193 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857001194 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857001195 TAP-like protein; Region: Abhydrolase_4; pfam08386 471857001196 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 471857001197 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471857001198 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 471857001199 trimer interface [polypeptide binding]; other site 471857001200 active site 471857001201 substrate binding site [chemical binding]; other site 471857001202 CoA binding site [chemical binding]; other site 471857001203 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471857001204 Glycoprotease family; Region: Peptidase_M22; pfam00814 471857001205 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471857001206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857001207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471857001208 Coenzyme A binding pocket [chemical binding]; other site 471857001209 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 471857001210 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471857001211 oligomerisation interface [polypeptide binding]; other site 471857001212 mobile loop; other site 471857001213 roof hairpin; other site 471857001214 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471857001215 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471857001216 ring oligomerisation interface [polypeptide binding]; other site 471857001217 ATP/Mg binding site [chemical binding]; other site 471857001218 stacking interactions; other site 471857001219 hinge regions; other site 471857001220 Transcription factor WhiB; Region: Whib; pfam02467 471857001221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857001222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857001223 active site 471857001224 phosphorylation site [posttranslational modification] 471857001225 intermolecular recognition site; other site 471857001226 dimerization interface [polypeptide binding]; other site 471857001227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857001228 DNA binding residues [nucleotide binding] 471857001229 dimerization interface [polypeptide binding]; other site 471857001230 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 471857001231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857001233 DNA binding residues [nucleotide binding] 471857001234 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471857001235 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471857001236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 471857001237 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471857001238 active site 471857001239 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471857001240 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471857001241 phosphate binding site [ion binding]; other site 471857001242 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857001243 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857001244 GMP synthase; Reviewed; Region: guaA; PRK00074 471857001245 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471857001246 AMP/PPi binding site [chemical binding]; other site 471857001247 candidate oxyanion hole; other site 471857001248 catalytic triad [active] 471857001249 potential glutamine specificity residues [chemical binding]; other site 471857001250 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471857001251 ATP Binding subdomain [chemical binding]; other site 471857001252 Ligand Binding sites [chemical binding]; other site 471857001253 Dimerization subdomain; other site 471857001254 E3 Ubiquitin ligase; Region: GIDE; pfam12483 471857001255 PspC domain; Region: PspC; pfam04024 471857001256 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471857001257 PspC domain; Region: PspC; cl00864 471857001258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857001259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001260 ATP binding site [chemical binding]; other site 471857001261 Mg2+ binding site [ion binding]; other site 471857001262 G-X-G motif; other site 471857001263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857001264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857001265 active site 471857001266 phosphorylation site [posttranslational modification] 471857001267 intermolecular recognition site; other site 471857001268 dimerization interface [polypeptide binding]; other site 471857001269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857001270 DNA binding residues [nucleotide binding] 471857001271 dimerization interface [polypeptide binding]; other site 471857001272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001274 active site 471857001275 ATP binding site [chemical binding]; other site 471857001276 substrate binding site [chemical binding]; other site 471857001277 activation loop (A-loop); other site 471857001278 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001279 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857001280 active site 471857001281 ATP binding site [chemical binding]; other site 471857001282 substrate binding site [chemical binding]; other site 471857001283 activation loop (A-loop); other site 471857001284 Chorismate mutase type II; Region: CM_2; cl00693 471857001285 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471857001286 Part of AAA domain; Region: AAA_19; pfam13245 471857001287 Family description; Region: UvrD_C_2; pfam13538 471857001288 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471857001289 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857001290 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471857001291 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471857001292 CoA-ligase; Region: Ligase_CoA; pfam00549 471857001293 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471857001294 CoA binding domain; Region: CoA_binding; smart00881 471857001295 CoA-ligase; Region: Ligase_CoA; pfam00549 471857001296 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471857001297 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471857001298 active site 471857001299 substrate binding site [chemical binding]; other site 471857001300 cosubstrate binding site; other site 471857001301 catalytic site [active] 471857001302 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471857001303 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471857001304 purine monophosphate binding site [chemical binding]; other site 471857001305 dimer interface [polypeptide binding]; other site 471857001306 putative catalytic residues [active] 471857001307 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 471857001308 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471857001309 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 471857001310 Protein of unknown function, DUF606; Region: DUF606; pfam04657 471857001311 Protein of unknown function, DUF606; Region: DUF606; pfam04657 471857001312 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471857001313 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471857001314 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471857001315 homodimer interface [polypeptide binding]; other site 471857001316 NADP binding site [chemical binding]; other site 471857001317 substrate binding site [chemical binding]; other site 471857001318 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 471857001319 Predicted membrane protein [Function unknown]; Region: COG2246 471857001320 GtrA-like protein; Region: GtrA; pfam04138 471857001321 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471857001322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001323 putative substrate translocation pore; other site 471857001324 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471857001325 isocitrate dehydrogenase; Validated; Region: PRK08299 471857001326 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 471857001327 putative active site [active] 471857001328 putative catalytic site [active] 471857001329 putative DNA binding site [nucleotide binding]; other site 471857001330 putative phosphate binding site [ion binding]; other site 471857001331 metal binding site A [ion binding]; metal-binding site 471857001332 putative AP binding site [nucleotide binding]; other site 471857001333 putative metal binding site B [ion binding]; other site 471857001334 Nuclease-related domain; Region: NERD; pfam08378 471857001335 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471857001336 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001337 active site 471857001338 ATP binding site [chemical binding]; other site 471857001339 substrate binding site [chemical binding]; other site 471857001340 activation loop (A-loop); other site 471857001341 Protein kinase domain; Region: Pkinase; pfam00069 471857001342 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001343 active site 471857001344 ATP binding site [chemical binding]; other site 471857001345 substrate binding site [chemical binding]; other site 471857001346 activation loop (A-loop); other site 471857001347 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471857001348 PglZ domain; Region: PglZ; pfam08665 471857001349 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 471857001350 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471857001351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857001352 ATP binding site [chemical binding]; other site 471857001353 putative Mg++ binding site [ion binding]; other site 471857001354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001355 nucleotide binding region [chemical binding]; other site 471857001356 ATP-binding site [chemical binding]; other site 471857001357 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 471857001358 hypothetical protein; Provisional; Region: PRK02237 471857001359 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 471857001360 active site 471857001361 Ca binding site [ion binding]; other site 471857001362 catalytic site [active] 471857001363 Aamy_C domain; Region: Aamy_C; smart00632 471857001364 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 471857001365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001366 putative substrate translocation pore; other site 471857001367 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471857001368 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 471857001369 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471857001370 CBD_II domain; Region: CBD_II; smart00637 471857001371 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 471857001372 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471857001373 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 471857001374 L-aspartate oxidase; Provisional; Region: PRK06175 471857001375 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471857001376 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 471857001377 putative Iron-sulfur protein interface [polypeptide binding]; other site 471857001378 putative proximal heme binding site [chemical binding]; other site 471857001379 putative SdhC-like subunit interface [polypeptide binding]; other site 471857001380 putative distal heme binding site [chemical binding]; other site 471857001381 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 471857001382 putative Iron-sulfur protein interface [polypeptide binding]; other site 471857001383 putative proximal heme binding site [chemical binding]; other site 471857001384 putative SdhD-like interface [polypeptide binding]; other site 471857001385 putative distal heme binding site [chemical binding]; other site 471857001386 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471857001387 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471857001388 ligand binding site [chemical binding]; other site 471857001389 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471857001390 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471857001391 Walker A/P-loop; other site 471857001392 ATP binding site [chemical binding]; other site 471857001393 Q-loop/lid; other site 471857001394 ABC transporter signature motif; other site 471857001395 Walker B; other site 471857001396 D-loop; other site 471857001397 H-loop/switch region; other site 471857001398 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471857001399 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857001400 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001401 TM-ABC transporter signature motif; other site 471857001402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857001403 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001404 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001405 TM-ABC transporter signature motif; other site 471857001406 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471857001407 active site 471857001408 catalytic motif [active] 471857001409 Zn binding site [ion binding]; other site 471857001410 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471857001411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471857001412 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471857001413 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 471857001414 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471857001415 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471857001416 adenosine deaminase; Provisional; Region: PRK09358 471857001417 active site 471857001418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857001419 ATP binding site [chemical binding]; other site 471857001420 putative Mg++ binding site [ion binding]; other site 471857001421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001422 nucleotide binding region [chemical binding]; other site 471857001423 ATP-binding site [chemical binding]; other site 471857001424 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471857001425 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857001426 NAD(P) binding site [chemical binding]; other site 471857001427 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 471857001428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857001429 NAD(P) binding site [chemical binding]; other site 471857001430 catalytic residues [active] 471857001431 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471857001432 intersubunit interface [polypeptide binding]; other site 471857001433 active site 471857001434 catalytic residue [active] 471857001435 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857001436 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471857001437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857001438 active site 471857001439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857001440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001441 WHG domain; Region: WHG; pfam13305 471857001442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857001443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001444 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471857001445 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471857001446 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471857001447 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471857001448 active site 471857001449 substrate binding site [chemical binding]; other site 471857001450 metal binding site [ion binding]; metal-binding site 471857001451 purine nucleoside phosphorylase; Provisional; Region: PRK08202 471857001452 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 471857001453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857001454 DNA binding residues [nucleotide binding] 471857001455 putative dimer interface [polypeptide binding]; other site 471857001456 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001457 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001458 active site 471857001459 ATP binding site [chemical binding]; other site 471857001460 substrate binding site [chemical binding]; other site 471857001461 activation loop (A-loop); other site 471857001462 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 471857001463 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 471857001464 heterodimer interface [polypeptide binding]; other site 471857001465 substrate interaction site [chemical binding]; other site 471857001466 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 471857001467 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471857001468 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 471857001469 active site 471857001470 substrate binding site [chemical binding]; other site 471857001471 coenzyme B12 binding site [chemical binding]; other site 471857001472 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471857001473 B12 binding site [chemical binding]; other site 471857001474 cobalt ligand [ion binding]; other site 471857001475 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471857001476 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471857001477 Walker A; other site 471857001478 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471857001479 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471857001480 metal binding site [ion binding]; metal-binding site 471857001481 putative dimer interface [polypeptide binding]; other site 471857001482 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471857001483 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471857001484 putative active site pocket [active] 471857001485 dimerization interface [polypeptide binding]; other site 471857001486 putative catalytic residue [active] 471857001487 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471857001488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857001489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857001490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857001491 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857001492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857001493 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857001494 glycerol kinase; Provisional; Region: glpK; PRK00047 471857001495 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471857001496 N- and C-terminal domain interface [polypeptide binding]; other site 471857001497 active site 471857001498 MgATP binding site [chemical binding]; other site 471857001499 catalytic site [active] 471857001500 metal binding site [ion binding]; metal-binding site 471857001501 putative homotetramer interface [polypeptide binding]; other site 471857001502 glycerol binding site [chemical binding]; other site 471857001503 homodimer interface [polypeptide binding]; other site 471857001504 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 471857001505 amphipathic channel; other site 471857001506 Asn-Pro-Ala signature motifs; other site 471857001507 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857001508 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 471857001509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857001510 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857001511 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857001512 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857001513 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471857001514 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471857001515 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857001516 carboxyltransferase (CT) interaction site; other site 471857001517 biotinylation site [posttranslational modification]; other site 471857001518 Maf-like protein; Region: Maf; pfam02545 471857001519 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471857001520 active site 471857001521 dimer interface [polypeptide binding]; other site 471857001522 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471857001523 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471857001524 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857001525 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 471857001526 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471857001527 Bacterial PH domain; Region: DUF304; pfam03703 471857001528 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471857001529 active site 471857001530 catalytic residues [active] 471857001531 metal binding site [ion binding]; metal-binding site 471857001532 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 471857001533 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471857001534 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471857001535 active site 471857001536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857001537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857001538 active site 471857001539 phosphorylation site [posttranslational modification] 471857001540 intermolecular recognition site; other site 471857001541 dimerization interface [polypeptide binding]; other site 471857001542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857001543 DNA binding site [nucleotide binding] 471857001544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857001545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857001546 dimer interface [polypeptide binding]; other site 471857001547 phosphorylation site [posttranslational modification] 471857001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001549 ATP binding site [chemical binding]; other site 471857001550 Mg2+ binding site [ion binding]; other site 471857001551 G-X-G motif; other site 471857001552 Predicted membrane protein [Function unknown]; Region: COG2246 471857001553 GtrA-like protein; Region: GtrA; pfam04138 471857001554 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857001555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857001557 DNA binding residues [nucleotide binding] 471857001558 Putative zinc-finger; Region: zf-HC2; pfam13490 471857001559 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 471857001560 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471857001561 ATP-grasp domain; Region: ATP-grasp; pfam02222 471857001562 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 471857001563 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857001564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857001565 acyl-activating enzyme (AAE) consensus motif; other site 471857001566 AMP binding site [chemical binding]; other site 471857001567 active site 471857001568 CoA binding site [chemical binding]; other site 471857001569 TIGR03089 family protein; Region: TIGR03089 471857001570 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471857001571 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471857001572 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471857001573 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471857001574 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471857001575 NAD binding site [chemical binding]; other site 471857001576 substrate binding site [chemical binding]; other site 471857001577 homodimer interface [polypeptide binding]; other site 471857001578 active site 471857001579 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 471857001580 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471857001581 NADP binding site [chemical binding]; other site 471857001582 active site 471857001583 putative substrate binding site [chemical binding]; other site 471857001584 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857001586 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471857001587 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471857001588 Probable Catalytic site; other site 471857001589 metal-binding site 471857001590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857001591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857001592 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857001593 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471857001594 Probable Catalytic site; other site 471857001595 metal-binding site 471857001596 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857001598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857001599 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001600 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471857001601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857001602 active site 471857001603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857001604 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471857001605 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471857001606 active site 471857001607 Substrate binding site; other site 471857001608 Mg++ binding site; other site 471857001609 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471857001610 N-terminal domain interface [polypeptide binding]; other site 471857001611 sulfate 1 binding site; other site 471857001612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857001613 minor groove reading motif; other site 471857001614 helix-hairpin-helix signature motif; other site 471857001615 substrate binding pocket [chemical binding]; other site 471857001616 active site 471857001617 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 471857001618 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 471857001619 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 471857001620 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471857001621 nudix motif; other site 471857001622 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 471857001623 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471857001624 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 471857001625 FMN binding site [chemical binding]; other site 471857001626 dimer interface [polypeptide binding]; other site 471857001627 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 471857001628 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 471857001629 dimer interface [polypeptide binding]; other site 471857001630 substrate binding site [chemical binding]; other site 471857001631 phosphate binding site [ion binding]; other site 471857001632 Ferredoxin [Energy production and conversion]; Region: COG1146 471857001633 4Fe-4S binding domain; Region: Fer4; pfam00037 471857001634 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 471857001635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857001636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857001637 homodimer interface [polypeptide binding]; other site 471857001638 catalytic residue [active] 471857001639 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 471857001640 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 471857001641 putative trimer interface [polypeptide binding]; other site 471857001642 putative CoA binding site [chemical binding]; other site 471857001643 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 471857001644 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471857001645 metal binding site [ion binding]; metal-binding site 471857001646 putative dimer interface [polypeptide binding]; other site 471857001647 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471857001648 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 471857001649 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857001650 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857001651 putative acyl-acceptor binding pocket; other site 471857001652 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 471857001653 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857001654 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471857001655 hydrophobic ligand binding site; other site 471857001656 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 471857001657 enoyl-CoA hydratase; Provisional; Region: PRK06688 471857001658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857001659 substrate binding site [chemical binding]; other site 471857001660 oxyanion hole (OAH) forming residues; other site 471857001661 trimer interface [polypeptide binding]; other site 471857001662 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471857001663 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 471857001664 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471857001665 interface (dimer of trimers) [polypeptide binding]; other site 471857001666 Substrate-binding/catalytic site; other site 471857001667 Zn-binding sites [ion binding]; other site 471857001668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857001669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857001670 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 471857001671 putative dimerization interface [polypeptide binding]; other site 471857001672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857001673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001674 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471857001675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857001676 S-adenosylmethionine binding site [chemical binding]; other site 471857001677 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 471857001678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857001680 DNA binding residues [nucleotide binding] 471857001681 Putative zinc-finger; Region: zf-HC2; pfam13490 471857001682 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471857001683 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471857001684 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471857001685 sec-independent translocase; Provisional; Region: PRK03100 471857001686 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471857001687 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471857001688 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471857001689 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857001690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471857001691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857001692 dimer interface [polypeptide binding]; other site 471857001693 conserved gate region; other site 471857001694 putative PBP binding loops; other site 471857001695 ABC-ATPase subunit interface; other site 471857001696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857001697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857001698 dimer interface [polypeptide binding]; other site 471857001699 conserved gate region; other site 471857001700 putative PBP binding loops; other site 471857001701 ABC-ATPase subunit interface; other site 471857001702 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471857001703 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471857001704 Walker A/P-loop; other site 471857001705 ATP binding site [chemical binding]; other site 471857001706 Q-loop/lid; other site 471857001707 ABC transporter signature motif; other site 471857001708 Walker B; other site 471857001709 D-loop; other site 471857001710 H-loop/switch region; other site 471857001711 TOBE domain; Region: TOBE_2; pfam08402 471857001712 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471857001713 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 471857001714 oligomer interface [polypeptide binding]; other site 471857001715 metal binding site [ion binding]; metal-binding site 471857001716 metal binding site [ion binding]; metal-binding site 471857001717 putative Cl binding site [ion binding]; other site 471857001718 basic sphincter; other site 471857001719 hydrophobic gate; other site 471857001720 periplasmic entrance; other site 471857001721 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 471857001722 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 471857001723 nudix motif; other site 471857001724 Bacterial PH domain; Region: DUF304; pfam03703 471857001725 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471857001726 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 471857001727 active site 471857001728 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 471857001729 MarC family integral membrane protein; Region: MarC; cl00919 471857001730 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471857001731 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857001732 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 471857001733 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471857001734 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471857001735 ATP binding site [chemical binding]; other site 471857001736 Mg++ binding site [ion binding]; other site 471857001737 motif III; other site 471857001738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001739 nucleotide binding region [chemical binding]; other site 471857001740 ATP-binding site [chemical binding]; other site 471857001741 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471857001742 dinuclear metal binding motif [ion binding]; other site 471857001743 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471857001744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857001745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001746 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 471857001747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857001748 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471857001749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001751 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471857001752 catalytic site [active] 471857001753 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 471857001754 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471857001755 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471857001756 ATP binding site [chemical binding]; other site 471857001757 substrate interface [chemical binding]; other site 471857001758 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857001759 active site residue [active] 471857001760 TIGR02569 family protein; Region: TIGR02569_actnb 471857001761 Putative esterase; Region: Esterase; pfam00756 471857001762 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471857001763 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471857001764 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857001765 FAD binding pocket [chemical binding]; other site 471857001766 FAD binding motif [chemical binding]; other site 471857001767 phosphate binding motif [ion binding]; other site 471857001768 NAD binding pocket [chemical binding]; other site 471857001769 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471857001770 DNA binding site [nucleotide binding] 471857001771 active site 471857001772 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857001773 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471857001774 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857001775 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471857001776 Ion channel; Region: Ion_trans_2; pfam07885 471857001777 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 471857001778 TrkA-N domain; Region: TrkA_N; pfam02254 471857001779 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471857001780 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471857001781 active site 471857001782 catalytic triad [active] 471857001783 oxyanion hole [active] 471857001784 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857001785 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857001786 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857001787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857001788 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857001789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857001790 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 471857001791 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471857001792 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471857001793 putative NADH binding site [chemical binding]; other site 471857001794 putative active site [active] 471857001795 nudix motif; other site 471857001796 putative metal binding site [ion binding]; other site 471857001797 CobD/Cbib protein; Region: CobD_Cbib; cl00561 471857001798 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471857001799 Phosphotransferase enzyme family; Region: APH; pfam01636 471857001800 Fructosamine kinase; Region: Fructosamin_kin; cl17579 471857001801 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471857001802 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471857001803 active site 471857001804 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857001805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001806 ATP binding site [chemical binding]; other site 471857001807 Mg2+ binding site [ion binding]; other site 471857001808 G-X-G motif; other site 471857001809 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 471857001810 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857001811 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857001812 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857001813 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471857001814 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471857001815 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857001816 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471857001817 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 471857001818 fumarylacetoacetase; Region: PLN02856 471857001819 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471857001820 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471857001821 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 471857001822 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 471857001823 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857001824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001825 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857001826 Cytochrome P450; Region: p450; cl12078 471857001827 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471857001828 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 471857001829 FMN-binding pocket [chemical binding]; other site 471857001830 flavin binding motif; other site 471857001831 phosphate binding motif [ion binding]; other site 471857001832 beta-alpha-beta structure motif; other site 471857001833 NAD binding pocket [chemical binding]; other site 471857001834 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857001835 catalytic loop [active] 471857001836 iron binding site [ion binding]; other site 471857001837 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 471857001838 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471857001839 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 471857001840 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 471857001841 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 471857001842 glucuronate isomerase; Reviewed; Region: PRK02925 471857001843 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 471857001844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857001845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857001846 DNA binding site [nucleotide binding] 471857001847 domain linker motif; other site 471857001848 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857001849 dimerization interface [polypeptide binding]; other site 471857001850 ligand binding site [chemical binding]; other site 471857001851 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471857001852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857001853 Walker A/P-loop; other site 471857001854 ATP binding site [chemical binding]; other site 471857001855 Q-loop/lid; other site 471857001856 ABC transporter signature motif; other site 471857001857 Walker B; other site 471857001858 D-loop; other site 471857001859 H-loop/switch region; other site 471857001860 TOBE domain; Region: TOBE_2; pfam08402 471857001861 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 471857001862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857001863 dimer interface [polypeptide binding]; other site 471857001864 conserved gate region; other site 471857001865 putative PBP binding loops; other site 471857001866 ABC-ATPase subunit interface; other site 471857001867 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471857001868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857001869 dimer interface [polypeptide binding]; other site 471857001870 conserved gate region; other site 471857001871 putative PBP binding loops; other site 471857001872 ABC-ATPase subunit interface; other site 471857001873 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471857001874 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 471857001875 putative active site pocket [active] 471857001876 putative metal binding site [ion binding]; other site 471857001877 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857001878 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857001879 substrate binding site [chemical binding]; other site 471857001880 ATP binding site [chemical binding]; other site 471857001881 galactarate dehydratase; Region: galactar-dH20; TIGR03248 471857001882 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 471857001883 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 471857001884 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471857001885 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471857001886 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471857001887 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857001888 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471857001889 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471857001890 Putative zinc ribbon domain; Region: DUF164; pfam02591 471857001891 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 471857001892 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 471857001893 RNA/DNA hybrid binding site [nucleotide binding]; other site 471857001894 active site 471857001895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857001896 catalytic core [active] 471857001897 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 471857001898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857001899 S-adenosylmethionine binding site [chemical binding]; other site 471857001900 AAA-like domain; Region: AAA_10; pfam12846 471857001901 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471857001902 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471857001903 NlpC/P60 family; Region: NLPC_P60; pfam00877 471857001904 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471857001905 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857001906 intersubunit interface [polypeptide binding]; other site 471857001907 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 471857001908 TAP-like protein; Region: Abhydrolase_4; pfam08386 471857001909 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471857001910 oligomerization interface [polypeptide binding]; other site 471857001911 active site 471857001912 metal binding site [ion binding]; metal-binding site 471857001913 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471857001914 DinB superfamily; Region: DinB_2; pfam12867 471857001915 NAD synthetase; Provisional; Region: PRK13981 471857001916 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471857001917 multimer interface [polypeptide binding]; other site 471857001918 active site 471857001919 catalytic triad [active] 471857001920 protein interface 1 [polypeptide binding]; other site 471857001921 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471857001922 homodimer interface [polypeptide binding]; other site 471857001923 NAD binding pocket [chemical binding]; other site 471857001924 ATP binding pocket [chemical binding]; other site 471857001925 Mg binding site [ion binding]; other site 471857001926 active-site loop [active] 471857001927 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 471857001928 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471857001929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001930 nucleotide binding region [chemical binding]; other site 471857001931 ATP-binding site [chemical binding]; other site 471857001932 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471857001933 TAP-like protein; Region: Abhydrolase_4; pfam08386 471857001934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001935 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471857001936 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471857001937 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471857001938 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471857001939 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471857001940 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 471857001941 catalytic triad [active] 471857001942 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471857001943 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471857001944 metal binding triad; other site 471857001945 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471857001946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471857001947 metal binding triad; other site 471857001948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471857001949 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471857001950 active site 471857001951 glutamine synthetase, type I; Region: GlnA; TIGR00653 471857001952 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471857001953 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471857001954 RDD family; Region: RDD; pfam06271 471857001955 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 471857001956 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471857001957 Part of AAA domain; Region: AAA_19; pfam13245 471857001958 Family description; Region: UvrD_C_2; pfam13538 471857001959 HRDC domain; Region: HRDC; pfam00570 471857001960 Transcription factor WhiB; Region: Whib; pfam02467 471857001961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471857001962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857001963 S-adenosylmethionine binding site [chemical binding]; other site 471857001964 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471857001965 ABC1 family; Region: ABC1; pfam03109 471857001966 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471857001967 active site 471857001968 ATP binding site [chemical binding]; other site 471857001969 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 471857001970 Protein of unknown function DUF45; Region: DUF45; cl00636 471857001971 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 471857001972 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 471857001973 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471857001974 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471857001975 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471857001976 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471857001977 hypothetical protein; Validated; Region: PRK00068 471857001978 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471857001979 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471857001980 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471857001981 RF-1 domain; Region: RF-1; pfam00472 471857001982 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471857001983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857001984 Walker A/P-loop; other site 471857001985 ATP binding site [chemical binding]; other site 471857001986 Q-loop/lid; other site 471857001987 ABC transporter signature motif; other site 471857001988 Walker B; other site 471857001989 D-loop; other site 471857001990 H-loop/switch region; other site 471857001991 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471857001992 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471857001993 SmpB-tmRNA interface; other site 471857001994 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 471857001995 active site 471857001996 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 471857001997 Dienelactone hydrolase family; Region: DLH; pfam01738 471857001998 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 471857001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857002000 ATP binding site [chemical binding]; other site 471857002001 putative Mg++ binding site [ion binding]; other site 471857002002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857002003 nucleotide binding region [chemical binding]; other site 471857002004 ATP-binding site [chemical binding]; other site 471857002005 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 471857002006 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 471857002007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857002008 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857002009 substrate binding pocket [chemical binding]; other site 471857002010 membrane-bound complex binding site; other site 471857002011 hinge residues; other site 471857002012 Methylamine utilisation protein MauE; Region: MauE; pfam07291 471857002013 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471857002014 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 471857002015 catalytic residues [active] 471857002016 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471857002017 NlpC/P60 family; Region: NLPC_P60; pfam00877 471857002018 Helix-turn-helix domain; Region: HTH_18; pfam12833 471857002019 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857002020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002021 putative substrate translocation pore; other site 471857002022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857002024 Helix-turn-helix domain; Region: HTH_31; pfam13560 471857002025 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 471857002026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857002027 nucleophilic elbow; other site 471857002028 catalytic triad; other site 471857002029 TspO/MBR family; Region: TspO_MBR; pfam03073 471857002030 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 471857002031 Acylphosphatase; Region: Acylphosphatase; pfam00708 471857002032 HypF finger; Region: zf-HYPF; pfam07503 471857002033 HypF finger; Region: zf-HYPF; pfam07503 471857002034 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 471857002035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857002036 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 471857002037 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 471857002038 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 471857002039 dimerization interface [polypeptide binding]; other site 471857002040 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 471857002041 ATP binding site [chemical binding]; other site 471857002042 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 471857002043 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 471857002044 HupF/HypC family; Region: HupF_HypC; pfam01455 471857002045 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 471857002046 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 471857002047 nickel binding site [ion binding]; other site 471857002048 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857002049 dimer interface [polypeptide binding]; other site 471857002050 active site 471857002051 HupF/HypC family; Region: HupF_HypC; cl00394 471857002052 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857002053 dimer interface [polypeptide binding]; other site 471857002054 active site 471857002055 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 471857002056 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 471857002057 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 471857002058 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857002059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857002060 S-adenosylmethionine binding site [chemical binding]; other site 471857002061 Transcription factor WhiB; Region: Whib; pfam02467 471857002062 ribonuclease Z; Reviewed; Region: PRK00055 471857002063 FOG: CBS domain [General function prediction only]; Region: COG0517 471857002064 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 471857002065 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471857002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857002067 ATP binding site [chemical binding]; other site 471857002068 Mg2+ binding site [ion binding]; other site 471857002069 G-X-G motif; other site 471857002070 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471857002071 anchoring element; other site 471857002072 dimer interface [polypeptide binding]; other site 471857002073 ATP binding site [chemical binding]; other site 471857002074 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471857002075 active site 471857002076 metal binding site [ion binding]; metal-binding site 471857002077 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471857002078 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471857002079 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471857002080 CAP-like domain; other site 471857002081 active site 471857002082 primary dimer interface [polypeptide binding]; other site 471857002083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857002084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857002085 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857002086 Ligand Binding Site [chemical binding]; other site 471857002087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857002088 Ligand Binding Site [chemical binding]; other site 471857002089 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857002090 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471857002091 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471857002092 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 471857002093 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857002094 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 471857002095 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471857002096 ATP binding site [chemical binding]; other site 471857002097 active site 471857002098 substrate binding site [chemical binding]; other site 471857002099 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857002100 UbiA prenyltransferase family; Region: UbiA; pfam01040 471857002101 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857002102 Cytochrome P450; Region: p450; cl12078 471857002103 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471857002104 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 471857002105 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 471857002106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857002107 S-adenosylmethionine binding site [chemical binding]; other site 471857002108 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857002109 FAD binding domain; Region: FAD_binding_4; pfam01565 471857002110 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857002111 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857002112 DNA binding residues [nucleotide binding] 471857002113 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857002114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857002115 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471857002116 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 471857002117 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857002118 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471857002119 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 471857002120 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471857002121 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471857002122 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471857002123 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 471857002124 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 471857002125 RNA binding site [nucleotide binding]; other site 471857002126 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 471857002127 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471857002128 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 471857002129 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471857002130 catalytic triad [active] 471857002131 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 471857002132 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471857002133 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471857002134 putative dimer interface [polypeptide binding]; other site 471857002135 active site pocket [active] 471857002136 putative cataytic base [active] 471857002137 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 471857002138 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857002139 FAD binding domain; Region: FAD_binding_4; pfam01565 471857002140 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471857002141 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 471857002142 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 471857002143 putative active site [active] 471857002144 metal binding site [ion binding]; metal-binding site 471857002145 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857002146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857002147 DNA-binding site [nucleotide binding]; DNA binding site 471857002148 FCD domain; Region: FCD; pfam07729 471857002149 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 471857002150 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 471857002151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857002153 putative substrate translocation pore; other site 471857002154 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471857002155 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471857002156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857002157 catalytic residue [active] 471857002158 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471857002159 acyl-CoA synthetase; Validated; Region: PRK08316 471857002160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857002161 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 471857002162 acyl-activating enzyme (AAE) consensus motif; other site 471857002163 acyl-activating enzyme (AAE) consensus motif; other site 471857002164 putative AMP binding site [chemical binding]; other site 471857002165 putative active site [active] 471857002166 putative CoA binding site [chemical binding]; other site 471857002167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857002168 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857002169 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 471857002170 putative active site [active] 471857002171 catalytic triad [active] 471857002172 putative dimer interface [polypeptide binding]; other site 471857002173 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 471857002174 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471857002175 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471857002176 nucleotide binding pocket [chemical binding]; other site 471857002177 K-X-D-G motif; other site 471857002178 catalytic site [active] 471857002179 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471857002180 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471857002181 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471857002182 Dimer interface [polypeptide binding]; other site 471857002183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857002184 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471857002185 Coenzyme A binding pocket [chemical binding]; other site 471857002186 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471857002187 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471857002188 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471857002189 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471857002190 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471857002191 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471857002192 GatB domain; Region: GatB_Yqey; smart00845 471857002193 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857002194 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 471857002195 putative ligand binding site [chemical binding]; other site 471857002196 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857002197 putative NAD binding site [chemical binding]; other site 471857002198 catalytic site [active] 471857002199 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857002200 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 471857002201 RHS Repeat; Region: RHS_repeat; pfam05593 471857002202 RHS Repeat; Region: RHS_repeat; pfam05593 471857002203 RHS Repeat; Region: RHS_repeat; pfam05593 471857002204 RHS Repeat; Region: RHS_repeat; pfam05593 471857002205 RHS Repeat; Region: RHS_repeat; pfam05593 471857002206 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857002207 RHS Repeat; Region: RHS_repeat; pfam05593 471857002208 RHS Repeat; Region: RHS_repeat; pfam05593 471857002209 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 471857002210 RHS Repeat; Region: RHS_repeat; pfam05593 471857002211 RHS Repeat; Region: RHS_repeat; cl11982 471857002212 RHS Repeat; Region: RHS_repeat; cl11982 471857002213 RHS Repeat; Region: RHS_repeat; cl11982 471857002214 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857002215 DoxX; Region: DoxX; pfam07681 471857002216 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 471857002217 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857002218 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471857002219 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857002220 PYR/PP interface [polypeptide binding]; other site 471857002221 dimer interface [polypeptide binding]; other site 471857002222 TPP binding site [chemical binding]; other site 471857002223 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 471857002224 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471857002225 TPP-binding site [chemical binding]; other site 471857002226 dimer interface [polypeptide binding]; other site 471857002227 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471857002228 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471857002229 putative valine binding site [chemical binding]; other site 471857002230 dimer interface [polypeptide binding]; other site 471857002231 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471857002232 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471857002233 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 471857002234 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471857002235 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857002236 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 471857002237 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 471857002238 ligand binding site [chemical binding]; other site 471857002239 NAD binding site [chemical binding]; other site 471857002240 dimerization interface [polypeptide binding]; other site 471857002241 catalytic site [active] 471857002242 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 471857002243 putative L-serine binding site [chemical binding]; other site 471857002244 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857002245 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 471857002246 tartrate dehydrogenase; Region: TTC; TIGR02089 471857002247 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471857002248 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 471857002249 active site 471857002250 catalytic residues [active] 471857002251 metal binding site [ion binding]; metal-binding site 471857002252 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471857002253 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471857002254 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471857002255 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471857002256 hypothetical protein; Provisional; Region: PRK06185 471857002257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857002258 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857002259 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471857002260 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471857002261 HIGH motif; other site 471857002262 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471857002263 active site 471857002264 KMSKS motif; other site 471857002265 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857002266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857002267 motif II; other site 471857002268 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857002269 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471857002270 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857002271 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471857002272 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471857002273 substrate binding site [chemical binding]; other site 471857002274 ligand binding site [chemical binding]; other site 471857002275 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 471857002276 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471857002277 substrate binding site [chemical binding]; other site 471857002278 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471857002279 active site 471857002280 Ap6A binding site [chemical binding]; other site 471857002281 nudix motif; other site 471857002282 metal binding site [ion binding]; metal-binding site 471857002283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857002284 catalytic core [active] 471857002285 polyphosphate kinase; Provisional; Region: PRK05443 471857002286 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471857002287 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471857002288 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471857002289 putative domain interface [polypeptide binding]; other site 471857002290 putative active site [active] 471857002291 catalytic site [active] 471857002292 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471857002293 putative domain interface [polypeptide binding]; other site 471857002294 putative active site [active] 471857002295 catalytic site [active] 471857002296 Guanylyl transferase CofC like; Region: CofC; cl17472 471857002297 Guanylyl transferase CofC like; Region: CofC; cl17472 471857002298 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857002299 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857002300 putative acyl-acceptor binding pocket; other site 471857002301 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471857002302 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471857002303 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471857002304 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 471857002305 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471857002306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857002307 DNA-binding site [nucleotide binding]; DNA binding site 471857002308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857002309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857002310 catalytic residue [active] 471857002311 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471857002312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471857002313 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857002314 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471857002315 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857002316 AsnC family; Region: AsnC_trans_reg; pfam01037 471857002317 thiamine monophosphate kinase; Provisional; Region: PRK05731 471857002318 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471857002319 ATP binding site [chemical binding]; other site 471857002320 dimerization interface [polypeptide binding]; other site 471857002321 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 471857002322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857002323 Coenzyme A binding pocket [chemical binding]; other site 471857002324 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471857002325 ligand binding site [chemical binding]; other site 471857002326 active site 471857002327 UGI interface [polypeptide binding]; other site 471857002328 catalytic site [active] 471857002329 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471857002330 DAK2 domain; Region: Dak2; cl03685 471857002331 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 471857002332 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471857002333 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471857002334 generic binding surface II; other site 471857002335 ssDNA binding site; other site 471857002336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857002337 ATP binding site [chemical binding]; other site 471857002338 putative Mg++ binding site [ion binding]; other site 471857002339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857002340 nucleotide binding region [chemical binding]; other site 471857002341 ATP-binding site [chemical binding]; other site 471857002342 pyruvate carboxylase; Reviewed; Region: PRK12999 471857002343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857002344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857002345 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471857002346 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471857002347 active site 471857002348 catalytic residues [active] 471857002349 metal binding site [ion binding]; metal-binding site 471857002350 homodimer binding site [polypeptide binding]; other site 471857002351 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857002352 carboxyltransferase (CT) interaction site; other site 471857002353 biotinylation site [posttranslational modification]; other site 471857002354 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 471857002355 active site 471857002356 Mn binding site [ion binding]; other site 471857002357 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857002358 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002359 mce related protein; Region: MCE; pfam02470 471857002360 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002361 mce related protein; Region: MCE; pfam02470 471857002362 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857002363 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002364 mce related protein; Region: MCE; pfam02470 471857002365 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002366 mce related protein; Region: MCE; pfam02470 471857002367 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857002368 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002369 mce related protein; Region: MCE; pfam02470 471857002370 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 471857002371 mce related protein; Region: MCE; pfam02470 471857002372 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857002373 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471857002374 Permease; Region: Permease; pfam02405 471857002375 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471857002376 Permease; Region: Permease; pfam02405 471857002377 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 471857002378 putative FMN binding site [chemical binding]; other site 471857002379 NADPH bind site [chemical binding]; other site 471857002380 Family description; Region: UvrD_C_2; pfam13538 471857002381 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 471857002382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857002383 S-adenosylmethionine binding site [chemical binding]; other site 471857002384 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471857002385 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471857002386 active site 471857002387 (T/H)XGH motif; other site 471857002388 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 471857002389 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 471857002390 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471857002391 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471857002392 ribonuclease III; Reviewed; Region: rnc; PRK00102 471857002393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471857002394 dimerization interface [polypeptide binding]; other site 471857002395 active site 471857002396 metal binding site [ion binding]; metal-binding site 471857002397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471857002398 dsRNA binding site [nucleotide binding]; other site 471857002399 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471857002400 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471857002401 DNA binding site [nucleotide binding] 471857002402 catalytic residue [active] 471857002403 H2TH interface [polypeptide binding]; other site 471857002404 putative catalytic residues [active] 471857002405 turnover-facilitating residue; other site 471857002406 intercalation triad [nucleotide binding]; other site 471857002407 8OG recognition residue [nucleotide binding]; other site 471857002408 putative reading head residues; other site 471857002409 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471857002410 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471857002411 Predicted transcriptional regulators [Transcription]; Region: COG1695 471857002412 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471857002413 Predicted membrane protein [Function unknown]; Region: COG4709 471857002414 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857002415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471857002416 acylphosphatase; Provisional; Region: PRK14422 471857002417 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471857002418 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471857002419 Walker A/P-loop; other site 471857002420 ATP binding site [chemical binding]; other site 471857002421 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 471857002422 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 471857002423 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471857002424 ABC transporter signature motif; other site 471857002425 Walker B; other site 471857002426 D-loop; other site 471857002427 H-loop/switch region; other site 471857002428 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 471857002429 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 471857002430 Na binding site [ion binding]; other site 471857002431 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 471857002432 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471857002433 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471857002434 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857002435 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471857002436 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857002437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857002438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857002439 DNA binding residues [nucleotide binding] 471857002440 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471857002441 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857002442 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857002443 malate synthase A; Region: malate_syn_A; TIGR01344 471857002444 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 471857002445 active site 471857002446 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 471857002447 putative active site [active] 471857002448 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 471857002449 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 471857002450 signal recognition particle protein; Provisional; Region: PRK10867 471857002451 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471857002452 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471857002453 P loop; other site 471857002454 GTP binding site [chemical binding]; other site 471857002455 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471857002456 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857002457 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857002458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857002459 active site 471857002460 CAAX protease self-immunity; Region: Abi; pfam02517 471857002461 CAAX protease self-immunity; Region: Abi; pfam02517 471857002462 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 471857002463 hypothetical protein; Provisional; Region: PRK02821 471857002464 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471857002465 G-X-X-G motif; other site 471857002466 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471857002467 RimM N-terminal domain; Region: RimM; pfam01782 471857002468 PRC-barrel domain; Region: PRC; pfam05239 471857002469 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471857002470 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471857002471 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471857002472 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471857002473 Catalytic site [active] 471857002474 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471857002475 RNA/DNA hybrid binding site [nucleotide binding]; other site 471857002476 active site 471857002477 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471857002478 hypothetical protein; Reviewed; Region: PRK12497 471857002479 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471857002480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471857002481 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471857002482 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471857002483 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471857002484 DNA protecting protein DprA; Region: dprA; TIGR00732 471857002485 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471857002486 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857002487 active site 471857002488 DNA binding site [nucleotide binding] 471857002489 Int/Topo IB signature motif; other site 471857002490 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 471857002491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857002492 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857002493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857002494 DNA binding residues [nucleotide binding] 471857002495 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471857002496 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857002497 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471857002498 rRNA interaction site [nucleotide binding]; other site 471857002499 S8 interaction site; other site 471857002500 elongation factor Ts; Provisional; Region: tsf; PRK09377 471857002501 UBA/TS-N domain; Region: UBA; pfam00627 471857002502 Elongation factor TS; Region: EF_TS; pfam00889 471857002503 Elongation factor TS; Region: EF_TS; pfam00889 471857002504 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471857002505 putative nucleotide binding site [chemical binding]; other site 471857002506 uridine monophosphate binding site [chemical binding]; other site 471857002507 homohexameric interface [polypeptide binding]; other site 471857002508 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471857002509 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471857002510 hinge region; other site 471857002511 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471857002512 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471857002513 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857002514 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857002515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857002516 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471857002517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857002518 FeS/SAM binding site; other site 471857002519 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 471857002520 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471857002521 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471857002522 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471857002523 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471857002524 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471857002525 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471857002526 active site 471857002527 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471857002528 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471857002529 putative substrate binding region [chemical binding]; other site 471857002530 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471857002531 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471857002532 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471857002533 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471857002534 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 471857002535 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471857002536 active site 471857002537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002538 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 471857002539 NAD(P) binding site [chemical binding]; other site 471857002540 active site 471857002541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002542 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857002543 putative substrate translocation pore; other site 471857002544 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471857002545 GAF domain; Region: GAF_2; pfam13185 471857002546 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857002547 transcriptional regulator NanR; Provisional; Region: PRK03837 471857002548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857002549 DNA-binding site [nucleotide binding]; DNA binding site 471857002550 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471857002551 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 471857002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002553 mycothione reductase; Reviewed; Region: PRK07846 471857002554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857002555 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002556 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 471857002557 cleavage site 471857002558 active site 471857002559 substrate binding sites [chemical binding]; other site 471857002560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471857002561 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 471857002562 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 471857002563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857002564 catalytic residue [active] 471857002565 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 471857002566 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471857002567 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471857002568 ATP binding site [chemical binding]; other site 471857002569 Mg++ binding site [ion binding]; other site 471857002570 motif III; other site 471857002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857002572 nucleotide binding region [chemical binding]; other site 471857002573 ATP-binding site [chemical binding]; other site 471857002574 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 471857002575 hypothetical protein; Validated; Region: PRK02101 471857002576 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471857002577 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471857002578 dimer interface [polypeptide binding]; other site 471857002579 motif 1; other site 471857002580 active site 471857002581 motif 2; other site 471857002582 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471857002583 putative deacylase active site [active] 471857002584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857002585 active site 471857002586 motif 3; other site 471857002587 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471857002588 anticodon binding site; other site 471857002589 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 471857002590 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 471857002591 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 471857002592 ligand binding site [chemical binding]; other site 471857002593 homodimer interface [polypeptide binding]; other site 471857002594 NAD(P) binding site [chemical binding]; other site 471857002595 trimer interface B [polypeptide binding]; other site 471857002596 trimer interface A [polypeptide binding]; other site 471857002597 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471857002598 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 471857002599 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 471857002600 Lsr2; Region: Lsr2; pfam11774 471857002601 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471857002602 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857002603 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857002604 dimer interface [polypeptide binding]; other site 471857002605 active site 471857002606 acyl carrier protein; Provisional; Region: acpP; PRK00982 471857002607 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471857002608 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471857002609 dimer interface [polypeptide binding]; other site 471857002610 active site 471857002611 CoA binding pocket [chemical binding]; other site 471857002612 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471857002613 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471857002614 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857002615 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471857002616 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471857002617 dimer interface [polypeptide binding]; other site 471857002618 TPP-binding site [chemical binding]; other site 471857002619 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471857002620 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471857002621 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 471857002622 dimer interface [polypeptide binding]; other site 471857002623 catalytic triad [active] 471857002624 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471857002625 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 471857002626 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857002627 Protein phosphatase 2C; Region: PP2C; pfam00481 471857002628 active site 471857002629 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471857002630 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471857002631 active site 471857002632 PHP Thumb interface [polypeptide binding]; other site 471857002633 metal binding site [ion binding]; metal-binding site 471857002634 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471857002635 generic binding surface I; other site 471857002636 generic binding surface II; other site 471857002637 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857002638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002639 putative substrate translocation pore; other site 471857002640 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857002641 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471857002642 lipoyl synthase; Provisional; Region: PRK05481 471857002643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857002644 FeS/SAM binding site; other site 471857002645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857002646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857002647 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471857002648 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857002649 lipoate-protein ligase B; Provisional; Region: PRK14345 471857002650 PAP2 superfamily; Region: PAP2; pfam01569 471857002651 active site 471857002652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002653 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 471857002654 NAD(P) binding site [chemical binding]; other site 471857002655 active site 471857002656 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857002657 E3 interaction surface; other site 471857002658 lipoyl attachment site [posttranslational modification]; other site 471857002659 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857002660 E3 interaction surface; other site 471857002661 lipoyl attachment site [posttranslational modification]; other site 471857002662 e3 binding domain; Region: E3_binding; pfam02817 471857002663 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471857002664 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471857002665 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471857002666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857002667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857002668 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002669 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 471857002670 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471857002671 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471857002672 interface (dimer of trimers) [polypeptide binding]; other site 471857002673 Substrate-binding/catalytic site; other site 471857002674 Zn-binding sites [ion binding]; other site 471857002675 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471857002676 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471857002677 homodimer interface [polypeptide binding]; other site 471857002678 substrate-cofactor binding pocket; other site 471857002679 catalytic residue [active] 471857002680 putative dimer interface [polypeptide binding]; other site 471857002681 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471857002682 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 471857002683 active site pocket [active] 471857002684 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471857002685 substrate binding site; other site 471857002686 dimer interface; other site 471857002687 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471857002688 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471857002689 active site 471857002690 catalytic tetrad [active] 471857002691 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471857002692 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 471857002693 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 471857002694 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471857002695 active site 471857002696 dimer interface [polypeptide binding]; other site 471857002697 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471857002698 Ligand Binding Site [chemical binding]; other site 471857002699 Molecular Tunnel; other site 471857002700 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471857002701 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471857002702 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471857002703 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471857002704 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471857002705 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471857002706 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471857002707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 471857002708 active site 471857002709 phosphorylation site [posttranslational modification] 471857002710 intermolecular recognition site; other site 471857002711 dimerization interface [polypeptide binding]; other site 471857002712 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471857002713 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471857002714 Cytochrome c; Region: Cytochrom_C; pfam00034 471857002715 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471857002716 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471857002717 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471857002718 iron-sulfur cluster [ion binding]; other site 471857002719 [2Fe-2S] cluster binding site [ion binding]; other site 471857002720 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471857002721 heme bH binding site [chemical binding]; other site 471857002722 intrachain domain interface; other site 471857002723 heme bL binding site [chemical binding]; other site 471857002724 interchain domain interface [polypeptide binding]; other site 471857002725 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 471857002726 Qo binding site; other site 471857002727 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857002728 AsnC family; Region: AsnC_trans_reg; pfam01037 471857002729 hypothetical protein; Validated; Region: PRK07883 471857002730 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471857002731 active site 471857002732 catalytic site [active] 471857002733 substrate binding site [chemical binding]; other site 471857002734 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471857002735 GIY-YIG motif/motif A; other site 471857002736 active site 471857002737 catalytic site [active] 471857002738 putative DNA binding site [nucleotide binding]; other site 471857002739 YacP-like NYN domain; Region: NYN_YacP; cl01491 471857002740 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471857002741 NlpC/P60 family; Region: NLPC_P60; pfam00877 471857002742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857002743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857002744 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471857002745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857002746 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 471857002747 inhibitor-cofactor binding pocket; inhibition site 471857002748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002749 catalytic residue [active] 471857002750 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 471857002751 biotin synthase; Validated; Region: PRK06256 471857002752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857002753 FeS/SAM binding site; other site 471857002754 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 471857002755 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 471857002756 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 471857002757 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471857002758 nudix motif; other site 471857002759 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 471857002760 quinolinate synthetase; Provisional; Region: PRK09375 471857002761 L-aspartate oxidase; Provisional; Region: PRK07804 471857002762 L-aspartate oxidase; Provisional; Region: PRK06175 471857002763 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471857002764 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 471857002765 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471857002766 dimerization interface [polypeptide binding]; other site 471857002767 active site 471857002768 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 471857002769 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857002770 putative active site [active] 471857002771 catalytic triad [active] 471857002772 putative dimer interface [polypeptide binding]; other site 471857002773 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 471857002774 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471857002775 NAD binding site [chemical binding]; other site 471857002776 dimerization interface [polypeptide binding]; other site 471857002777 product binding site; other site 471857002778 substrate binding site [chemical binding]; other site 471857002779 zinc binding site [ion binding]; other site 471857002780 catalytic residues [active] 471857002781 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 471857002782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857002783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002784 homodimer interface [polypeptide binding]; other site 471857002785 catalytic residue [active] 471857002786 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471857002787 putative active site pocket [active] 471857002788 4-fold oligomerization interface [polypeptide binding]; other site 471857002789 metal binding residues [ion binding]; metal-binding site 471857002790 3-fold/trimer interface [polypeptide binding]; other site 471857002791 MMPL family; Region: MMPL; pfam03176 471857002792 MMPL family; Region: MMPL; pfam03176 471857002793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857002794 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 471857002795 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 471857002796 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857002797 DNA binding residues [nucleotide binding] 471857002798 dimer interface [polypeptide binding]; other site 471857002799 [2Fe-2S] cluster binding site [ion binding]; other site 471857002800 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857002801 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 471857002802 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857002803 tetramer interface [polypeptide binding]; other site 471857002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002805 catalytic residue [active] 471857002806 Domain of unknown function (DUF385); Region: DUF385; pfam04075 471857002807 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857002808 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857002809 putative acyl-acceptor binding pocket; other site 471857002810 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 471857002811 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 471857002812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857002813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002814 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471857002815 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471857002816 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471857002817 Walker A/P-loop; other site 471857002818 ATP binding site [chemical binding]; other site 471857002819 Q-loop/lid; other site 471857002820 ABC transporter signature motif; other site 471857002821 Walker B; other site 471857002822 D-loop; other site 471857002823 H-loop/switch region; other site 471857002824 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471857002825 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857002826 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857002827 TM-ABC transporter signature motif; other site 471857002828 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857002829 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471857002830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857002831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471857002832 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471857002833 Trehalose utilisation; Region: ThuA; pfam06283 471857002834 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857002835 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857002836 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857002837 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 471857002838 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471857002839 metal binding site [ion binding]; metal-binding site 471857002840 ligand binding site [chemical binding]; other site 471857002841 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471857002842 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 471857002843 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 471857002844 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 471857002845 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 471857002846 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857002847 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 471857002848 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471857002849 TatD related DNase; Region: TatD_DNase; pfam01026 471857002850 active site 471857002851 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857002852 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471857002853 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471857002854 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857002855 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471857002856 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857002857 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471857002858 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857002859 anti sigma factor interaction site; other site 471857002860 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471857002861 regulatory phosphorylation site [posttranslational modification]; other site 471857002862 FOG: CBS domain [General function prediction only]; Region: COG0517 471857002863 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 471857002864 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471857002865 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471857002866 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471857002867 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471857002868 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471857002869 putative active site [active] 471857002870 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471857002871 classical (c) SDRs; Region: SDR_c; cd05233 471857002872 NAD(P) binding site [chemical binding]; other site 471857002873 active site 471857002874 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 471857002875 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471857002876 substrate binding site [chemical binding]; other site 471857002877 ATP binding site [chemical binding]; other site 471857002878 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 471857002879 active site 471857002880 HIGH motif; other site 471857002881 nucleotide binding site [chemical binding]; other site 471857002882 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857002883 dimer interface [polypeptide binding]; other site 471857002884 active site 471857002885 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471857002886 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471857002887 putative active site [active] 471857002888 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471857002889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002890 active site 471857002891 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 471857002892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857002893 active site 471857002894 motif I; other site 471857002895 motif II; other site 471857002896 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471857002897 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471857002898 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857002899 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 471857002900 NAD binding site [chemical binding]; other site 471857002901 putative substrate binding site 2 [chemical binding]; other site 471857002902 putative substrate binding site 1 [chemical binding]; other site 471857002903 active site 471857002904 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471857002905 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857002906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002907 active site 471857002908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471857002909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002910 active site 471857002911 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471857002912 Clp amino terminal domain; Region: Clp_N; pfam02861 471857002913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857002914 Walker A motif; other site 471857002915 ATP binding site [chemical binding]; other site 471857002916 Walker B motif; other site 471857002917 arginine finger; other site 471857002918 UvrB/uvrC motif; Region: UVR; pfam02151 471857002919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857002920 Walker A motif; other site 471857002921 ATP binding site [chemical binding]; other site 471857002922 Walker B motif; other site 471857002923 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471857002924 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471857002925 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 471857002926 putative ADP-binding pocket [chemical binding]; other site 471857002927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857002928 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857002929 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 471857002930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857002931 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857002932 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 471857002933 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471857002934 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 471857002935 putative methyltransferase; Provisional; Region: PRK14967 471857002936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857002937 S-adenosylmethionine binding site [chemical binding]; other site 471857002938 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 471857002939 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471857002940 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471857002941 Peptidase family M50; Region: Peptidase_M50; pfam02163 471857002942 putative substrate binding region [chemical binding]; other site 471857002943 FOG: CBS domain [General function prediction only]; Region: COG0517 471857002944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 471857002945 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857002946 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 471857002947 putative NAD(P) binding site [chemical binding]; other site 471857002948 active site 471857002949 putative substrate binding site [chemical binding]; other site 471857002950 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 471857002951 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471857002952 dihydropteroate synthase; Region: DHPS; TIGR01496 471857002953 substrate binding pocket [chemical binding]; other site 471857002954 dimer interface [polypeptide binding]; other site 471857002955 inhibitor binding site; inhibition site 471857002956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857002957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857002958 active site 471857002959 phosphorylation site [posttranslational modification] 471857002960 intermolecular recognition site; other site 471857002961 dimerization interface [polypeptide binding]; other site 471857002962 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857002963 DNA binding residues [nucleotide binding] 471857002964 dimerization interface [polypeptide binding]; other site 471857002965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857002966 Histidine kinase; Region: HisKA_3; pfam07730 471857002967 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857002968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471857002969 Walker A/P-loop; other site 471857002970 ATP binding site [chemical binding]; other site 471857002971 Q-loop/lid; other site 471857002972 ABC transporter signature motif; other site 471857002973 Walker B; other site 471857002974 D-loop; other site 471857002975 H-loop/switch region; other site 471857002976 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857002977 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471857002978 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471857002979 nucleoside/Zn binding site; other site 471857002980 dimer interface [polypeptide binding]; other site 471857002981 catalytic motif [active] 471857002982 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471857002983 nudix motif; other site 471857002984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857002985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857002986 DNA binding site [nucleotide binding] 471857002987 domain linker motif; other site 471857002988 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 471857002989 putative dimerization interface [polypeptide binding]; other site 471857002990 putative ligand binding site [chemical binding]; other site 471857002991 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 471857002992 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471857002993 active site 471857002994 catalytic site [active] 471857002995 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471857002996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857002997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857002998 dimer interface [polypeptide binding]; other site 471857002999 conserved gate region; other site 471857003000 putative PBP binding loops; other site 471857003001 ABC-ATPase subunit interface; other site 471857003002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857003003 putative PBP binding loops; other site 471857003004 ABC-ATPase subunit interface; other site 471857003005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857003006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471857003007 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471857003008 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857003009 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471857003010 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857003011 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857003012 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 471857003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003014 S-adenosylmethionine binding site [chemical binding]; other site 471857003015 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857003016 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 471857003017 FAD binding site [chemical binding]; other site 471857003018 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857003019 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857003020 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857003021 putative active site [active] 471857003022 putative substrate binding site [chemical binding]; other site 471857003023 putative cosubstrate binding site; other site 471857003024 catalytic site [active] 471857003025 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 471857003026 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471857003027 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471857003028 homodimer interface [polypeptide binding]; other site 471857003029 NADP binding site [chemical binding]; other site 471857003030 substrate binding site [chemical binding]; other site 471857003031 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 471857003032 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 471857003033 putative molybdopterin cofactor binding site [chemical binding]; other site 471857003034 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 471857003035 putative molybdopterin cofactor binding site; other site 471857003036 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471857003037 dihydropteroate synthase; Region: DHPS; TIGR01496 471857003038 substrate binding pocket [chemical binding]; other site 471857003039 dimer interface [polypeptide binding]; other site 471857003040 inhibitor binding site; inhibition site 471857003041 Tetratricopeptide repeat; Region: TPR_10; pfam13374 471857003042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857003043 Copper resistance protein D; Region: CopD; cl00563 471857003044 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 471857003045 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471857003046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857003047 Walker A/P-loop; other site 471857003048 ATP binding site [chemical binding]; other site 471857003049 Q-loop/lid; other site 471857003050 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857003051 ABC transporter; Region: ABC_tran_2; pfam12848 471857003052 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857003053 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 471857003054 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 471857003055 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471857003056 active site 471857003057 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471857003058 apolar tunnel; other site 471857003059 heme binding site [chemical binding]; other site 471857003060 dimerization interface [polypeptide binding]; other site 471857003061 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471857003062 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471857003063 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 471857003064 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471857003065 active site 471857003066 Repair protein; Region: Repair_PSII; pfam04536 471857003067 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471857003068 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471857003069 Zn binding site [ion binding]; other site 471857003070 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471857003071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857003072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857003073 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 471857003074 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471857003075 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 471857003076 putative DNA binding site [nucleotide binding]; other site 471857003077 catalytic residue [active] 471857003078 putative H2TH interface [polypeptide binding]; other site 471857003079 putative catalytic residues [active] 471857003080 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471857003081 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471857003082 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471857003083 NlpC/P60 family; Region: NLPC_P60; pfam00877 471857003084 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 471857003085 putative active site; other site 471857003086 putative triphosphate binding site [ion binding]; other site 471857003087 putative metal binding residues [ion binding]; other site 471857003088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003089 sequence-specific DNA binding site [nucleotide binding]; other site 471857003090 salt bridge; other site 471857003091 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857003092 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857003093 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 471857003094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003095 S-adenosylmethionine binding site [chemical binding]; other site 471857003096 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471857003097 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471857003098 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 471857003099 Na binding site [ion binding]; other site 471857003100 Protein of unknown function, DUF485; Region: DUF485; pfam04341 471857003101 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857003102 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857003103 Na binding site [ion binding]; other site 471857003104 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471857003105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857003106 active site 471857003107 phosphorylation site [posttranslational modification] 471857003108 intermolecular recognition site; other site 471857003109 dimerization interface [polypeptide binding]; other site 471857003110 LytTr DNA-binding domain; Region: LytTR; smart00850 471857003111 Histidine kinase; Region: His_kinase; pfam06580 471857003112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857003113 ATP binding site [chemical binding]; other site 471857003114 Mg2+ binding site [ion binding]; other site 471857003115 G-X-G motif; other site 471857003116 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 471857003117 trigger factor; Provisional; Region: tig; PRK01490 471857003118 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471857003119 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471857003120 Clp protease; Region: CLP_protease; pfam00574 471857003121 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471857003122 oligomer interface [polypeptide binding]; other site 471857003123 active site residues [active] 471857003124 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471857003125 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471857003126 oligomer interface [polypeptide binding]; other site 471857003127 active site residues [active] 471857003128 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471857003129 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471857003130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857003131 Walker A motif; other site 471857003132 ATP binding site [chemical binding]; other site 471857003133 Walker B motif; other site 471857003134 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471857003135 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 471857003136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857003137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857003138 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857003139 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 471857003140 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 471857003141 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471857003142 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471857003143 HIGH motif; other site 471857003144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471857003145 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471857003146 active site 471857003147 KMSKS motif; other site 471857003148 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471857003149 tRNA binding surface [nucleotide binding]; other site 471857003150 anticodon binding site; other site 471857003151 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471857003152 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857003153 active site 471857003154 catalytic triad [active] 471857003155 oxyanion hole [active] 471857003156 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471857003157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471857003158 Walker A/P-loop; other site 471857003159 ATP binding site [chemical binding]; other site 471857003160 Q-loop/lid; other site 471857003161 ABC transporter signature motif; other site 471857003162 Walker B; other site 471857003163 D-loop; other site 471857003164 H-loop/switch region; other site 471857003165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471857003166 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857003167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857003168 TM-ABC transporter signature motif; other site 471857003169 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857003170 TM-ABC transporter signature motif; other site 471857003171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 471857003172 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 471857003173 putative ligand binding site [chemical binding]; other site 471857003174 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857003175 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471857003176 DNA interaction; other site 471857003177 Trehalose utilisation; Region: ThuA; pfam06283 471857003178 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857003179 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471857003180 FOG: PKD repeat [General function prediction only]; Region: COG3291 471857003181 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857003182 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471857003183 metal binding site [ion binding]; metal-binding site 471857003184 ligand binding site [chemical binding]; other site 471857003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857003186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857003187 putative substrate translocation pore; other site 471857003188 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857003189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003190 S-adenosylmethionine binding site [chemical binding]; other site 471857003191 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471857003192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857003193 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857003194 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 471857003195 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471857003196 active site 471857003197 multimer interface [polypeptide binding]; other site 471857003198 SdpI/YhfL protein family; Region: SdpI; pfam13630 471857003199 BNR repeat-like domain; Region: BNR_2; pfam13088 471857003200 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 471857003201 Asp-box motif; other site 471857003202 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471857003203 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857003204 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857003205 active site 471857003206 catalytic residues [active] 471857003207 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857003208 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471857003209 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471857003210 homodimer interface [polypeptide binding]; other site 471857003211 oligonucleotide binding site [chemical binding]; other site 471857003212 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471857003213 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471857003214 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471857003215 GTP1/OBG; Region: GTP1_OBG; pfam01018 471857003216 Obg GTPase; Region: Obg; cd01898 471857003217 G1 box; other site 471857003218 GTP/Mg2+ binding site [chemical binding]; other site 471857003219 Switch I region; other site 471857003220 G2 box; other site 471857003221 G3 box; other site 471857003222 Switch II region; other site 471857003223 G4 box; other site 471857003224 G5 box; other site 471857003225 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 471857003226 gamma-glutamyl kinase; Provisional; Region: PRK05429 471857003227 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471857003228 nucleotide binding site [chemical binding]; other site 471857003229 homotetrameric interface [polypeptide binding]; other site 471857003230 putative phosphate binding site [ion binding]; other site 471857003231 putative allosteric binding site; other site 471857003232 PUA domain; Region: PUA; pfam01472 471857003233 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471857003234 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471857003235 active site 471857003236 (T/H)XGH motif; other site 471857003237 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 471857003238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857003239 catalytic core [active] 471857003240 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471857003241 active site 471857003242 catalytic triad [active] 471857003243 oxyanion hole [active] 471857003244 EDD domain protein, DegV family; Region: DegV; TIGR00762 471857003245 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471857003246 SLBB domain; Region: SLBB; pfam10531 471857003247 comEA protein; Region: comE; TIGR01259 471857003248 Helix-hairpin-helix motif; Region: HHH; pfam00633 471857003249 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 471857003250 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471857003251 Competence protein; Region: Competence; pfam03772 471857003252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857003253 threonine synthase; Validated; Region: PRK07591 471857003254 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471857003255 homodimer interface [polypeptide binding]; other site 471857003256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003257 catalytic residue [active] 471857003258 hypothetical protein; Reviewed; Region: PRK07914 471857003259 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471857003260 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471857003261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857003262 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471857003263 active site 471857003264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003265 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 471857003266 GTP-binding protein LepA; Provisional; Region: PRK05433 471857003267 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471857003268 G1 box; other site 471857003269 putative GEF interaction site [polypeptide binding]; other site 471857003270 GTP/Mg2+ binding site [chemical binding]; other site 471857003271 Switch I region; other site 471857003272 G2 box; other site 471857003273 G3 box; other site 471857003274 Switch II region; other site 471857003275 G4 box; other site 471857003276 G5 box; other site 471857003277 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471857003278 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471857003279 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471857003280 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471857003281 Nitronate monooxygenase; Region: NMO; pfam03060 471857003282 FMN binding site [chemical binding]; other site 471857003283 substrate binding site [chemical binding]; other site 471857003284 putative catalytic residue [active] 471857003285 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857003286 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471857003287 NAD(P) binding site [chemical binding]; other site 471857003288 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 471857003289 putative RNAase interaction site [polypeptide binding]; other site 471857003290 enoyl-CoA hydratase; Provisional; Region: PRK07827 471857003291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857003292 substrate binding site [chemical binding]; other site 471857003293 oxyanion hole (OAH) forming residues; other site 471857003294 trimer interface [polypeptide binding]; other site 471857003295 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 471857003296 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471857003297 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471857003298 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471857003299 putative active site [active] 471857003300 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 471857003301 putative active site [active] 471857003302 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 471857003303 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 471857003304 CysD dimerization site [polypeptide binding]; other site 471857003305 G1 box; other site 471857003306 putative GEF interaction site [polypeptide binding]; other site 471857003307 GTP/Mg2+ binding site [chemical binding]; other site 471857003308 Switch I region; other site 471857003309 G2 box; other site 471857003310 G3 box; other site 471857003311 Switch II region; other site 471857003312 G4 box; other site 471857003313 G5 box; other site 471857003314 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 471857003315 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 471857003316 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 471857003317 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471857003318 Active Sites [active] 471857003319 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471857003320 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471857003321 Active Sites [active] 471857003322 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 471857003323 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857003324 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857003325 coproporphyrinogen III oxidase; Validated; Region: PRK05628 471857003326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857003327 FeS/SAM binding site; other site 471857003328 Uncharacterized conserved protein [Function unknown]; Region: COG3268 471857003329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003330 Transcription factor WhiB; Region: Whib; pfam02467 471857003331 Predicted membrane protein [Function unknown]; Region: COG2149 471857003332 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857003333 anti sigma factor interaction site; other site 471857003334 regulatory phosphorylation site [posttranslational modification]; other site 471857003335 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 471857003336 Fe-S cluster binding site [ion binding]; other site 471857003337 active site 471857003338 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471857003339 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471857003340 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471857003341 NAD binding site [chemical binding]; other site 471857003342 catalytic Zn binding site [ion binding]; other site 471857003343 structural Zn binding site [ion binding]; other site 471857003344 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 471857003345 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471857003346 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 471857003347 dimerization interface [polypeptide binding]; other site 471857003348 ligand binding site [chemical binding]; other site 471857003349 NADP binding site [chemical binding]; other site 471857003350 catalytic site [active] 471857003351 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 471857003352 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 471857003353 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 471857003354 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857003355 dimer interface [polypeptide binding]; other site 471857003356 active site 471857003357 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 471857003358 heterodimer interface [polypeptide binding]; other site 471857003359 multimer interface [polypeptide binding]; other site 471857003360 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 471857003361 active site 471857003362 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 471857003363 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 471857003364 heterodimer interface [polypeptide binding]; other site 471857003365 active site 471857003366 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 471857003367 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 471857003368 tetramer interface [polypeptide binding]; other site 471857003369 active site 471857003370 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857003371 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471857003372 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471857003373 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 471857003374 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 471857003375 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857003376 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857003377 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 471857003378 metal-binding site 471857003379 MoxR-like ATPases [General function prediction only]; Region: COG0714 471857003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857003381 Walker A motif; other site 471857003382 ATP binding site [chemical binding]; other site 471857003383 Walker B motif; other site 471857003384 arginine finger; other site 471857003385 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 471857003386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471857003387 metal ion-dependent adhesion site (MIDAS); other site 471857003388 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471857003389 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 471857003390 XdhC Rossmann domain; Region: XdhC_C; pfam13478 471857003391 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857003392 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857003393 catalytic loop [active] 471857003394 iron binding site [ion binding]; other site 471857003395 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857003396 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857003397 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471857003398 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857003399 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857003400 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 471857003401 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 471857003402 putative hydrophobic ligand binding site [chemical binding]; other site 471857003403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471857003404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471857003405 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 471857003406 active site 471857003407 putative catalytic site [active] 471857003408 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471857003409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857003410 Walker A/P-loop; other site 471857003411 ATP binding site [chemical binding]; other site 471857003412 Q-loop/lid; other site 471857003413 ABC transporter signature motif; other site 471857003414 Walker B; other site 471857003415 D-loop; other site 471857003416 H-loop/switch region; other site 471857003417 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857003418 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471857003419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857003420 Walker A/P-loop; other site 471857003421 ATP binding site [chemical binding]; other site 471857003422 Q-loop/lid; other site 471857003423 ABC transporter signature motif; other site 471857003424 Walker B; other site 471857003425 D-loop; other site 471857003426 H-loop/switch region; other site 471857003427 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471857003428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857003429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857003430 putative PBP binding loops; other site 471857003431 dimer interface [polypeptide binding]; other site 471857003432 ABC-ATPase subunit interface; other site 471857003433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857003434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857003435 dimer interface [polypeptide binding]; other site 471857003436 conserved gate region; other site 471857003437 putative PBP binding loops; other site 471857003438 ABC-ATPase subunit interface; other site 471857003439 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857003440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857003441 DNA binding site [nucleotide binding] 471857003442 domain linker motif; other site 471857003443 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857003444 dimerization interface [polypeptide binding]; other site 471857003445 ligand binding site [chemical binding]; other site 471857003446 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471857003447 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857003448 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471857003449 PLD-like domain; Region: PLDc_2; pfam13091 471857003450 putative active site [active] 471857003451 catalytic site [active] 471857003452 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471857003453 PLD-like domain; Region: PLDc_2; pfam13091 471857003454 putative active site [active] 471857003455 catalytic site [active] 471857003456 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857003457 catalytic core [active] 471857003458 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471857003459 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471857003460 nucleotide binding site [chemical binding]; other site 471857003461 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471857003462 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 471857003463 putative N- and C-terminal domain interface [polypeptide binding]; other site 471857003464 putative active site [active] 471857003465 MgATP binding site [chemical binding]; other site 471857003466 catalytic site [active] 471857003467 metal binding site [ion binding]; metal-binding site 471857003468 putative xylulose binding site [chemical binding]; other site 471857003469 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857003470 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 471857003471 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471857003472 glycine dehydrogenase; Provisional; Region: PRK05367 471857003473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857003474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857003475 catalytic residue [active] 471857003476 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471857003477 tetramer interface [polypeptide binding]; other site 471857003478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003479 catalytic residue [active] 471857003480 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471857003481 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857003482 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471857003483 lipoyl attachment site [posttranslational modification]; other site 471857003484 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471857003485 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471857003486 dimer interface [polypeptide binding]; other site 471857003487 active site 471857003488 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471857003489 folate binding site [chemical binding]; other site 471857003490 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471857003491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003492 S-adenosylmethionine binding site [chemical binding]; other site 471857003493 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471857003494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857003495 putative substrate translocation pore; other site 471857003496 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471857003497 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857003498 DNA binding residues [nucleotide binding] 471857003499 drug binding residues [chemical binding]; other site 471857003500 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 471857003501 beta-clamp/clamp loader binding surface; other site 471857003502 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 471857003503 beta-clamp/translesion DNA polymerase binding surface; other site 471857003504 beta-clamp/clamp loader binding surface; other site 471857003505 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 471857003506 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 471857003507 putative active site [active] 471857003508 putative substrate binding site [chemical binding]; other site 471857003509 putative FMN binding site [chemical binding]; other site 471857003510 putative catalytic residues [active] 471857003511 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 471857003512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857003513 ATP binding site [chemical binding]; other site 471857003514 putative Mg++ binding site [ion binding]; other site 471857003515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857003516 nucleotide binding region [chemical binding]; other site 471857003517 ATP-binding site [chemical binding]; other site 471857003518 Helicase associated domain (HA2); Region: HA2; pfam04408 471857003519 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471857003520 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471857003521 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 471857003522 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 471857003523 active site 471857003524 DNA binding site [nucleotide binding] 471857003525 catalytic site [active] 471857003526 acyl-CoA synthetase; Validated; Region: PRK07788 471857003527 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857003528 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 471857003529 putative active site [active] 471857003530 putative CoA binding site [chemical binding]; other site 471857003531 putative AMP binding site [chemical binding]; other site 471857003532 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 471857003533 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471857003534 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 471857003535 calcium binding site 2 [ion binding]; other site 471857003536 active site 471857003537 catalytic triad [active] 471857003538 calcium binding site 1 [ion binding]; other site 471857003539 short chain dehydrogenase; Provisional; Region: PRK08251 471857003540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003541 NAD(P) binding site [chemical binding]; other site 471857003542 active site 471857003543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857003544 catalytic core [active] 471857003545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857003546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857003547 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857003548 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857003549 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471857003550 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857003551 FAD binding pocket [chemical binding]; other site 471857003552 FAD binding motif [chemical binding]; other site 471857003553 phosphate binding motif [ion binding]; other site 471857003554 NAD binding pocket [chemical binding]; other site 471857003555 Subtilisin inhibitor-like; Region: SSI; cl11594 471857003556 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471857003557 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 471857003558 chaperone protein DnaJ; Provisional; Region: PRK14278 471857003559 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471857003560 HSP70 interaction site [polypeptide binding]; other site 471857003561 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471857003562 Zn binding sites [ion binding]; other site 471857003563 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471857003564 dimer interface [polypeptide binding]; other site 471857003565 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 471857003566 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471857003567 nucleotide binding site/active site [active] 471857003568 HIT family signature motif; other site 471857003569 catalytic residue [active] 471857003570 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471857003571 PhoH-like protein; Region: PhoH; pfam02562 471857003572 metal-binding heat shock protein; Provisional; Region: PRK00016 471857003573 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857003574 FOG: CBS domain [General function prediction only]; Region: COG0517 471857003575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857003576 Transporter associated domain; Region: CorC_HlyC; smart01091 471857003577 GTPase Era; Reviewed; Region: era; PRK00089 471857003578 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471857003579 G1 box; other site 471857003580 GTP/Mg2+ binding site [chemical binding]; other site 471857003581 Switch I region; other site 471857003582 G2 box; other site 471857003583 Switch II region; other site 471857003584 G3 box; other site 471857003585 G4 box; other site 471857003586 G5 box; other site 471857003587 KH domain; Region: KH_2; pfam07650 471857003588 RDD family; Region: RDD; pfam06271 471857003589 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471857003590 Recombination protein O N terminal; Region: RecO_N; pfam11967 471857003591 Recombination protein O C terminal; Region: RecO_C; pfam02565 471857003592 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471857003593 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471857003594 catalytic residue [active] 471857003595 putative FPP diphosphate binding site; other site 471857003596 putative FPP binding hydrophobic cleft; other site 471857003597 dimer interface [polypeptide binding]; other site 471857003598 putative IPP diphosphate binding site; other site 471857003599 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857003600 metal binding site 2 [ion binding]; metal-binding site 471857003601 putative DNA binding helix; other site 471857003602 metal binding site 1 [ion binding]; metal-binding site 471857003603 dimer interface [polypeptide binding]; other site 471857003604 structural Zn2+ binding site [ion binding]; other site 471857003605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857003606 dimerization interface [polypeptide binding]; other site 471857003607 putative DNA binding site [nucleotide binding]; other site 471857003608 putative Zn2+ binding site [ion binding]; other site 471857003609 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 471857003610 active site 471857003611 putative catalytic site [active] 471857003612 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471857003613 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857003614 motif 1; other site 471857003615 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 471857003616 active site 471857003617 motif 2; other site 471857003618 motif 3; other site 471857003619 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471857003620 anticodon binding site; other site 471857003621 Uncharacterized conserved protein [Function unknown]; Region: COG1434 471857003622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471857003623 putative active site [active] 471857003624 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471857003625 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857003626 homodimer interface [polypeptide binding]; other site 471857003627 substrate-cofactor binding pocket; other site 471857003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003629 catalytic residue [active] 471857003630 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 471857003631 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 471857003632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471857003633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857003634 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857003635 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 471857003636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471857003637 Zn2+ binding site [ion binding]; other site 471857003638 Mg2+ binding site [ion binding]; other site 471857003639 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 471857003640 reactive center loop; other site 471857003641 DNA primase; Validated; Region: dnaG; PRK05667 471857003642 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471857003643 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471857003644 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471857003645 active site 471857003646 metal binding site [ion binding]; metal-binding site 471857003647 interdomain interaction site; other site 471857003648 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471857003649 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 471857003650 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471857003651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003652 S-adenosylmethionine binding site [chemical binding]; other site 471857003653 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 471857003654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471857003655 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471857003656 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471857003657 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 471857003658 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857003659 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857003660 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471857003661 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 471857003662 BCCT family transporter; Region: BCCT; pfam02028 471857003663 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471857003664 active site 471857003665 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471857003666 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 471857003667 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857003668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857003669 DNA-binding site [nucleotide binding]; DNA binding site 471857003670 UTRA domain; Region: UTRA; pfam07702 471857003671 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857003672 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 471857003673 cyanate hydratase; Validated; Region: PRK02866 471857003674 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 471857003675 oligomer interface [polypeptide binding]; other site 471857003676 active site 471857003677 hydroperoxidase II; Provisional; Region: katE; PRK11249 471857003678 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 471857003679 heme binding pocket [chemical binding]; other site 471857003680 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 471857003681 domain interactions; other site 471857003682 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471857003683 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471857003684 active site 471857003685 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 471857003686 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471857003687 putative hydrophobic ligand binding site [chemical binding]; other site 471857003688 NAD-dependent deacetylase; Provisional; Region: PRK05333 471857003689 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471857003690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857003691 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 471857003692 AsnC family; Region: AsnC_trans_reg; pfam01037 471857003693 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 471857003694 TPP-binding site [chemical binding]; other site 471857003695 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 471857003696 PYR/PP interface [polypeptide binding]; other site 471857003697 dimer interface [polypeptide binding]; other site 471857003698 TPP binding site [chemical binding]; other site 471857003699 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857003700 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 471857003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857003702 S-adenosylmethionine binding site [chemical binding]; other site 471857003703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003705 non-specific DNA binding site [nucleotide binding]; other site 471857003706 salt bridge; other site 471857003707 sequence-specific DNA binding site [nucleotide binding]; other site 471857003708 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471857003709 dimer interface [polypeptide binding]; other site 471857003710 ADP-ribose binding site [chemical binding]; other site 471857003711 active site 471857003712 nudix motif; other site 471857003713 metal binding site [ion binding]; metal-binding site 471857003714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003715 sequence-specific DNA binding site [nucleotide binding]; other site 471857003716 salt bridge; other site 471857003717 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857003718 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857003719 Na binding site [ion binding]; other site 471857003720 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471857003721 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471857003722 dimer interface [polypeptide binding]; other site 471857003723 active site 471857003724 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471857003725 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471857003726 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471857003727 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471857003728 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471857003729 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471857003730 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471857003731 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471857003732 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857003733 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471857003734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471857003735 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471857003736 catalytic residues [active] 471857003737 dimer interface [polypeptide binding]; other site 471857003738 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 471857003739 active site 471857003740 catalytic triad [active] 471857003741 oxyanion hole [active] 471857003742 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 471857003743 Na2 binding site [ion binding]; other site 471857003744 putative substrate binding site 1 [chemical binding]; other site 471857003745 Na binding site 1 [ion binding]; other site 471857003746 putative substrate binding site 2 [chemical binding]; other site 471857003747 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 471857003748 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471857003749 Short C-terminal domain; Region: SHOCT; pfam09851 471857003750 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 471857003751 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 471857003752 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471857003753 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 471857003754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471857003755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857003756 ChaB; Region: ChaB; pfam06150 471857003757 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471857003758 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857003759 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471857003760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857003761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857003762 DNA binding residues [nucleotide binding] 471857003763 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471857003764 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 471857003765 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471857003766 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471857003767 putative active site [active] 471857003768 putative metal binding site [ion binding]; other site 471857003769 Uncharacterized conserved protein [Function unknown]; Region: COG3402 471857003770 Bacterial PH domain; Region: DUF304; pfam03703 471857003771 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857003772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857003773 catalytic residue [active] 471857003774 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471857003775 Sm and related proteins; Region: Sm_like; cl00259 471857003776 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471857003777 putative oligomer interface [polypeptide binding]; other site 471857003778 putative RNA binding site [nucleotide binding]; other site 471857003779 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471857003780 NusA N-terminal domain; Region: NusA_N; pfam08529 471857003781 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471857003782 RNA binding site [nucleotide binding]; other site 471857003783 homodimer interface [polypeptide binding]; other site 471857003784 NusA-like KH domain; Region: KH_5; pfam13184 471857003785 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471857003786 G-X-X-G motif; other site 471857003787 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 471857003788 putative RNA binding cleft [nucleotide binding]; other site 471857003789 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857003790 translation initiation factor IF-2; Region: IF-2; TIGR00487 471857003791 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857003792 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471857003793 G1 box; other site 471857003794 putative GEF interaction site [polypeptide binding]; other site 471857003795 GTP/Mg2+ binding site [chemical binding]; other site 471857003796 Switch I region; other site 471857003797 G2 box; other site 471857003798 G3 box; other site 471857003799 Switch II region; other site 471857003800 G4 box; other site 471857003801 G5 box; other site 471857003802 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471857003803 Translation-initiation factor 2; Region: IF-2; pfam11987 471857003804 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471857003805 Protein of unknown function (DUF503); Region: DUF503; pfam04456 471857003806 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471857003807 AAA domain; Region: AAA_33; pfam13671 471857003808 AAA domain; Region: AAA_17; pfam13207 471857003809 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471857003810 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471857003811 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 471857003812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857003813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857003814 putative substrate translocation pore; other site 471857003815 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471857003816 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471857003817 RNA binding site [nucleotide binding]; other site 471857003818 active site 471857003819 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 471857003820 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471857003821 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471857003822 active site 471857003823 Riboflavin kinase; Region: Flavokinase; pfam01687 471857003824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003825 non-specific DNA binding site [nucleotide binding]; other site 471857003826 salt bridge; other site 471857003827 sequence-specific DNA binding site [nucleotide binding]; other site 471857003828 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 471857003829 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471857003830 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471857003831 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471857003832 16S/18S rRNA binding site [nucleotide binding]; other site 471857003833 S13e-L30e interaction site [polypeptide binding]; other site 471857003834 25S rRNA binding site [nucleotide binding]; other site 471857003835 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471857003836 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 471857003837 oligomer interface [polypeptide binding]; other site 471857003838 RNA binding site [nucleotide binding]; other site 471857003839 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471857003840 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471857003841 RNase E interface [polypeptide binding]; other site 471857003842 trimer interface [polypeptide binding]; other site 471857003843 active site 471857003844 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471857003845 putative nucleic acid binding region [nucleotide binding]; other site 471857003846 G-X-X-G motif; other site 471857003847 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471857003848 RNA binding site [nucleotide binding]; other site 471857003849 domain interface; other site 471857003850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857003851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857003852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857003853 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471857003854 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471857003855 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471857003856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471857003857 TPR motif; other site 471857003858 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 471857003859 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857003860 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471857003861 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471857003862 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 471857003863 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 471857003864 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857003865 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 471857003866 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471857003867 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 471857003868 cytidylate kinase; Provisional; Region: cmk; PRK00023 471857003869 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471857003870 CMP-binding site; other site 471857003871 The sites determining sugar specificity; other site 471857003872 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857003873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857003874 putative acyl-acceptor binding pocket; other site 471857003875 GTP-binding protein Der; Reviewed; Region: PRK03003 471857003876 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471857003877 G1 box; other site 471857003878 GTP/Mg2+ binding site [chemical binding]; other site 471857003879 Switch I region; other site 471857003880 G2 box; other site 471857003881 Switch II region; other site 471857003882 G3 box; other site 471857003883 G4 box; other site 471857003884 G5 box; other site 471857003885 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471857003886 G1 box; other site 471857003887 GTP/Mg2+ binding site [chemical binding]; other site 471857003888 Switch I region; other site 471857003889 G2 box; other site 471857003890 G3 box; other site 471857003891 Switch II region; other site 471857003892 G4 box; other site 471857003893 G5 box; other site 471857003894 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857003895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857003896 nucleotide binding site [chemical binding]; other site 471857003897 PAC2 family; Region: PAC2; pfam09754 471857003898 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 471857003899 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471857003900 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 471857003901 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471857003902 active site 471857003903 dimer interface [polypeptide binding]; other site 471857003904 motif 1; other site 471857003905 motif 2; other site 471857003906 motif 3; other site 471857003907 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471857003908 anticodon binding site; other site 471857003909 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471857003910 nucleotide binding site/active site [active] 471857003911 HIT family signature motif; other site 471857003912 catalytic residue [active] 471857003913 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471857003914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857003915 MarR family; Region: MarR_2; pfam12802 471857003916 MarR family; Region: MarR_2; cl17246 471857003917 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471857003918 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 471857003919 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471857003920 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471857003921 putative acyl-acceptor binding pocket; other site 471857003922 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857003923 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857003924 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471857003925 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471857003926 active site 471857003927 multimer interface [polypeptide binding]; other site 471857003928 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857003929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003930 non-specific DNA binding site [nucleotide binding]; other site 471857003931 salt bridge; other site 471857003932 sequence-specific DNA binding site [nucleotide binding]; other site 471857003933 AzlC protein; Region: AzlC; pfam03591 471857003934 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 471857003935 hypothetical protein; Validated; Region: PRK00110 471857003936 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 471857003937 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 471857003938 active site 471857003939 putative DNA-binding cleft [nucleotide binding]; other site 471857003940 dimer interface [polypeptide binding]; other site 471857003941 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471857003942 RuvA N terminal domain; Region: RuvA_N; pfam01330 471857003943 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471857003944 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471857003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857003946 Walker A motif; other site 471857003947 ATP binding site [chemical binding]; other site 471857003948 Walker B motif; other site 471857003949 arginine finger; other site 471857003950 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471857003951 Preprotein translocase subunit; Region: YajC; cl00806 471857003952 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471857003953 Protein export membrane protein; Region: SecD_SecF; cl14618 471857003954 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471857003955 Protein export membrane protein; Region: SecD_SecF; pfam02355 471857003956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857003957 active site 471857003958 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471857003959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471857003960 Zn2+ binding site [ion binding]; other site 471857003961 Mg2+ binding site [ion binding]; other site 471857003962 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471857003963 synthetase active site [active] 471857003964 NTP binding site [chemical binding]; other site 471857003965 metal binding site [ion binding]; metal-binding site 471857003966 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471857003967 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471857003968 enoyl-CoA hydratase; Provisional; Region: PRK06127 471857003969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857003970 substrate binding site [chemical binding]; other site 471857003971 oxyanion hole (OAH) forming residues; other site 471857003972 trimer interface [polypeptide binding]; other site 471857003973 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 471857003974 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471857003975 homodimer interface [polypeptide binding]; other site 471857003976 substrate-cofactor binding pocket; other site 471857003977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003978 catalytic residue [active] 471857003979 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471857003980 active site 471857003981 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471857003982 YibE/F-like protein; Region: YibE_F; pfam07907 471857003983 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 471857003984 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857003985 PYR/PP interface [polypeptide binding]; other site 471857003986 dimer interface [polypeptide binding]; other site 471857003987 TPP binding site [chemical binding]; other site 471857003988 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857003989 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 471857003990 TPP-binding site [chemical binding]; other site 471857003991 dimer interface [polypeptide binding]; other site 471857003992 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857003993 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857003994 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857003995 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471857003996 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471857003997 dimer interface [polypeptide binding]; other site 471857003998 anticodon binding site; other site 471857003999 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471857004000 homodimer interface [polypeptide binding]; other site 471857004001 motif 1; other site 471857004002 active site 471857004003 motif 2; other site 471857004004 GAD domain; Region: GAD; pfam02938 471857004005 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471857004006 motif 3; other site 471857004007 recombination factor protein RarA; Reviewed; Region: PRK13342 471857004008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857004009 Walker A motif; other site 471857004010 ATP binding site [chemical binding]; other site 471857004011 Walker B motif; other site 471857004012 arginine finger; other site 471857004013 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471857004014 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471857004015 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471857004016 motif 1; other site 471857004017 active site 471857004018 motif 2; other site 471857004019 motif 3; other site 471857004020 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471857004021 DHHA1 domain; Region: DHHA1; pfam02272 471857004022 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 471857004023 YceG-like family; Region: YceG; pfam02618 471857004024 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 471857004025 dimerization interface [polypeptide binding]; other site 471857004026 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471857004027 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471857004028 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471857004029 shikimate binding site; other site 471857004030 NAD(P) binding site [chemical binding]; other site 471857004031 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471857004032 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 471857004033 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857004034 dimerization interface [polypeptide binding]; other site 471857004035 NAD binding site [chemical binding]; other site 471857004036 ligand binding site [chemical binding]; other site 471857004037 catalytic site [active] 471857004038 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857004039 Beta-lactamase; Region: Beta-lactamase; pfam00144 471857004040 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857004041 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857004042 active site 471857004043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 471857004044 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471857004045 dimerization domain swap beta strand [polypeptide binding]; other site 471857004046 regulatory protein interface [polypeptide binding]; other site 471857004047 active site 471857004048 regulatory phosphorylation site [posttranslational modification]; other site 471857004049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 471857004050 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 471857004051 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857004052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857004053 DNA-binding site [nucleotide binding]; DNA binding site 471857004054 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 471857004055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471857004056 active site turn [active] 471857004057 phosphorylation site [posttranslational modification] 471857004058 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 471857004059 HPr interaction site; other site 471857004060 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471857004061 active site 471857004062 phosphorylation site [posttranslational modification] 471857004063 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471857004064 iron-sulfur cluster [ion binding]; other site 471857004065 [2Fe-2S] cluster binding site [ion binding]; other site 471857004066 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471857004067 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471857004068 Tetramer interface [polypeptide binding]; other site 471857004069 active site 471857004070 FMN-binding site [chemical binding]; other site 471857004071 shikimate kinase; Reviewed; Region: aroK; PRK00131 471857004072 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471857004073 ADP binding site [chemical binding]; other site 471857004074 magnesium binding site [ion binding]; other site 471857004075 putative shikimate binding site; other site 471857004076 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471857004077 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 471857004078 active site 471857004079 dimer interface [polypeptide binding]; other site 471857004080 metal binding site [ion binding]; metal-binding site 471857004081 Dehydroquinase class II; Region: DHquinase_II; pfam01220 471857004082 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471857004083 trimer interface [polypeptide binding]; other site 471857004084 active site 471857004085 dimer interface [polypeptide binding]; other site 471857004086 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471857004087 active site 471857004088 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471857004089 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471857004090 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471857004091 active site 471857004092 elongation factor P; Validated; Region: PRK00529 471857004093 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471857004094 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471857004095 RNA binding site [nucleotide binding]; other site 471857004096 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471857004097 RNA binding site [nucleotide binding]; other site 471857004098 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471857004099 putative RNA binding site [nucleotide binding]; other site 471857004100 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857004101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857004102 non-specific DNA binding site [nucleotide binding]; other site 471857004103 salt bridge; other site 471857004104 sequence-specific DNA binding site [nucleotide binding]; other site 471857004105 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 471857004106 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471857004107 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 471857004108 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471857004109 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471857004110 dihydroorotase; Validated; Region: pyrC; PRK09357 471857004111 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857004112 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471857004113 active site 471857004114 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471857004115 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 471857004116 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471857004117 catalytic site [active] 471857004118 subunit interface [polypeptide binding]; other site 471857004119 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471857004120 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857004121 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857004122 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471857004123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857004124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857004125 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471857004126 IMP binding site; other site 471857004127 dimer interface [polypeptide binding]; other site 471857004128 interdomain contacts; other site 471857004129 partial ornithine binding site; other site 471857004130 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471857004131 active site 471857004132 dimer interface [polypeptide binding]; other site 471857004133 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471857004134 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 471857004135 catalytic site [active] 471857004136 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 471857004137 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471857004138 Flavoprotein; Region: Flavoprotein; pfam02441 471857004139 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471857004140 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471857004141 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471857004142 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471857004143 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471857004144 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857004145 primosome assembly protein PriA; Provisional; Region: PRK14873 471857004146 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471857004147 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471857004148 putative active site [active] 471857004149 substrate binding site [chemical binding]; other site 471857004150 putative cosubstrate binding site; other site 471857004151 catalytic site [active] 471857004152 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471857004153 substrate binding site [chemical binding]; other site 471857004154 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471857004155 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471857004156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857004157 S-adenosylmethionine binding site [chemical binding]; other site 471857004158 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 471857004159 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471857004160 substrate binding site [chemical binding]; other site 471857004161 hexamer interface [polypeptide binding]; other site 471857004162 metal binding site [ion binding]; metal-binding site 471857004163 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471857004164 catalytic motif [active] 471857004165 Zn binding site [ion binding]; other site 471857004166 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 471857004167 RibD C-terminal domain; Region: RibD_C; pfam01872 471857004168 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471857004169 Lumazine binding domain; Region: Lum_binding; pfam00677 471857004170 Lumazine binding domain; Region: Lum_binding; pfam00677 471857004171 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471857004172 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471857004173 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471857004174 dimerization interface [polypeptide binding]; other site 471857004175 active site 471857004176 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471857004177 homopentamer interface [polypeptide binding]; other site 471857004178 active site 471857004179 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857004180 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471857004181 EamA-like transporter family; Region: EamA; pfam00892 471857004182 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471857004183 putative catalytic site [active] 471857004184 putative phosphate binding site [ion binding]; other site 471857004185 active site 471857004186 metal binding site A [ion binding]; metal-binding site 471857004187 DNA binding site [nucleotide binding] 471857004188 putative AP binding site [nucleotide binding]; other site 471857004189 putative metal binding site B [ion binding]; other site 471857004190 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471857004191 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471857004192 GIY-YIG motif/motif A; other site 471857004193 active site 471857004194 catalytic site [active] 471857004195 putative DNA binding site [nucleotide binding]; other site 471857004196 metal binding site [ion binding]; metal-binding site 471857004197 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471857004198 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 471857004199 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471857004200 dimer interface [polypeptide binding]; other site 471857004201 phosphate binding site [ion binding]; other site 471857004202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471857004203 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471857004204 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 471857004205 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471857004206 putative hydrophobic ligand binding site [chemical binding]; other site 471857004207 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471857004208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471857004209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471857004210 Phosphoglycerate kinase; Region: PGK; pfam00162 471857004211 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471857004212 substrate binding site [chemical binding]; other site 471857004213 hinge regions; other site 471857004214 ADP binding site [chemical binding]; other site 471857004215 catalytic site [active] 471857004216 triosephosphate isomerase; Provisional; Region: PRK14567 471857004217 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471857004218 substrate binding site [chemical binding]; other site 471857004219 dimer interface [polypeptide binding]; other site 471857004220 catalytic triad [active] 471857004221 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471857004222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857004223 Histidine kinase; Region: HisKA_3; pfam07730 471857004224 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471857004225 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471857004226 putative active site [active] 471857004227 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 471857004228 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 471857004229 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471857004230 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471857004231 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471857004232 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 471857004233 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857004234 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857004235 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471857004236 putative active site [active] 471857004237 transaldolase; Provisional; Region: PRK03903 471857004238 catalytic residue [active] 471857004239 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471857004240 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471857004241 TPP-binding site [chemical binding]; other site 471857004242 dimer interface [polypeptide binding]; other site 471857004243 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857004244 PYR/PP interface [polypeptide binding]; other site 471857004245 dimer interface [polypeptide binding]; other site 471857004246 TPP binding site [chemical binding]; other site 471857004247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857004248 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 471857004249 UbiA prenyltransferase family; Region: UbiA; pfam01040 471857004250 Part of AAA domain; Region: AAA_19; pfam13245 471857004251 Family description; Region: UvrD_C_2; pfam13538 471857004252 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471857004253 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 471857004254 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471857004255 NADP binding site [chemical binding]; other site 471857004256 dimer interface [polypeptide binding]; other site 471857004257 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 471857004258 active site 471857004259 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857004260 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857004261 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471857004262 Di-iron ligands [ion binding]; other site 471857004263 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471857004264 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471857004265 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471857004266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857004267 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471857004268 Walker A/P-loop; other site 471857004269 ATP binding site [chemical binding]; other site 471857004270 Q-loop/lid; other site 471857004271 ABC transporter signature motif; other site 471857004272 Walker B; other site 471857004273 D-loop; other site 471857004274 H-loop/switch region; other site 471857004275 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 471857004276 Predicted transcriptional regulator [Transcription]; Region: COG2345 471857004277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857004278 putative DNA binding site [nucleotide binding]; other site 471857004279 putative Zn2+ binding site [ion binding]; other site 471857004280 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471857004281 FeS assembly protein SufB; Region: sufB; TIGR01980 471857004282 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471857004283 FeS assembly protein SufD; Region: sufD; TIGR01981 471857004284 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 471857004285 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471857004286 Walker A/P-loop; other site 471857004287 ATP binding site [chemical binding]; other site 471857004288 Q-loop/lid; other site 471857004289 ABC transporter signature motif; other site 471857004290 Walker B; other site 471857004291 D-loop; other site 471857004292 H-loop/switch region; other site 471857004293 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857004294 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471857004295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857004296 catalytic residue [active] 471857004297 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471857004298 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471857004299 trimerization site [polypeptide binding]; other site 471857004300 active site 471857004301 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471857004302 Beta-lactamase; Region: Beta-lactamase; pfam00144 471857004303 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857004304 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857004305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857004306 Walker A/P-loop; other site 471857004307 ATP binding site [chemical binding]; other site 471857004308 Q-loop/lid; other site 471857004309 ABC transporter signature motif; other site 471857004310 Walker B; other site 471857004311 D-loop; other site 471857004312 H-loop/switch region; other site 471857004313 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 471857004314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857004315 Walker A/P-loop; other site 471857004316 ATP binding site [chemical binding]; other site 471857004317 Q-loop/lid; other site 471857004318 ABC transporter signature motif; other site 471857004319 Walker B; other site 471857004320 D-loop; other site 471857004321 H-loop/switch region; other site 471857004322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857004323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857004324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857004325 dimer interface [polypeptide binding]; other site 471857004326 conserved gate region; other site 471857004327 putative PBP binding loops; other site 471857004328 ABC-ATPase subunit interface; other site 471857004329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857004330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857004331 dimer interface [polypeptide binding]; other site 471857004332 conserved gate region; other site 471857004333 putative PBP binding loops; other site 471857004334 ABC-ATPase subunit interface; other site 471857004335 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 471857004336 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471857004337 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471857004338 active site 471857004339 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 471857004340 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857004341 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857004342 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 471857004343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857004344 sequence-specific DNA binding site [nucleotide binding]; other site 471857004345 salt bridge; other site 471857004346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004348 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857004349 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 471857004350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471857004351 Zn2+ binding site [ion binding]; other site 471857004352 Mg2+ binding site [ion binding]; other site 471857004353 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471857004354 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857004355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857004356 Walker A/P-loop; other site 471857004357 ATP binding site [chemical binding]; other site 471857004358 Q-loop/lid; other site 471857004359 ABC transporter signature motif; other site 471857004360 Walker B; other site 471857004361 D-loop; other site 471857004362 H-loop/switch region; other site 471857004363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857004364 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471857004365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857004366 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471857004367 Walker A/P-loop; other site 471857004368 ATP binding site [chemical binding]; other site 471857004369 Q-loop/lid; other site 471857004370 ABC transporter signature motif; other site 471857004371 Walker B; other site 471857004372 D-loop; other site 471857004373 H-loop/switch region; other site 471857004374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857004375 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471857004376 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471857004377 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471857004378 catalytic triad [active] 471857004379 PAS fold; Region: PAS; pfam00989 471857004380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857004381 putative active site [active] 471857004382 heme pocket [chemical binding]; other site 471857004383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471857004384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857004385 metal binding site [ion binding]; metal-binding site 471857004386 active site 471857004387 I-site; other site 471857004388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857004389 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 471857004390 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471857004391 dimer interface [polypeptide binding]; other site 471857004392 putative radical transfer pathway; other site 471857004393 diiron center [ion binding]; other site 471857004394 tyrosyl radical; other site 471857004395 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 471857004396 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471857004397 active site 471857004398 dimer interface [polypeptide binding]; other site 471857004399 catalytic residues [active] 471857004400 effector binding site; other site 471857004401 R2 peptide binding site; other site 471857004402 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857004403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471857004404 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471857004405 Helix-turn-helix domain; Region: HTH_18; pfam12833 471857004406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857004407 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 471857004408 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471857004409 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471857004410 dimer interface [polypeptide binding]; other site 471857004411 putative anticodon binding site; other site 471857004412 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857004413 motif 1; other site 471857004414 dimer interface [polypeptide binding]; other site 471857004415 active site 471857004416 motif 2; other site 471857004417 motif 3; other site 471857004418 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 471857004419 enoyl-CoA hydratase; Provisional; Region: PRK08260 471857004420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857004421 substrate binding site [chemical binding]; other site 471857004422 oxyanion hole (OAH) forming residues; other site 471857004423 trimer interface [polypeptide binding]; other site 471857004424 TIGR03084 family protein; Region: TIGR03084 471857004425 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471857004426 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 471857004427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004428 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004429 active site 471857004430 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471857004431 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857004432 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857004433 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 471857004434 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857004435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857004436 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857004437 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471857004438 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857004439 carboxyltransferase (CT) interaction site; other site 471857004440 biotinylation site [posttranslational modification]; other site 471857004441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004442 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004443 active site 471857004444 short chain dehydrogenase; Provisional; Region: PRK08278 471857004445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004446 NAD(P) binding site [chemical binding]; other site 471857004447 active site 471857004448 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857004449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004450 carbon starvation protein A; Provisional; Region: PRK15015 471857004451 Carbon starvation protein CstA; Region: CstA; pfam02554 471857004452 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 471857004453 Protein of unknown function (DUF466); Region: DUF466; pfam04328 471857004454 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857004455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857004456 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857004457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857004458 amino acid transporter; Region: 2A0306; TIGR00909 471857004459 Spore germination protein; Region: Spore_permease; cl17796 471857004460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004462 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 471857004463 active site 471857004464 intersubunit interface [polypeptide binding]; other site 471857004465 zinc binding site [ion binding]; other site 471857004466 Na+ binding site [ion binding]; other site 471857004467 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471857004468 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857004469 dimer interface [polypeptide binding]; other site 471857004470 active site 471857004471 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857004472 dimer interface [polypeptide binding]; other site 471857004473 active site 471857004474 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857004475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857004476 nucleotide binding site [chemical binding]; other site 471857004477 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471857004478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857004479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857004480 dimer interface [polypeptide binding]; other site 471857004481 conserved gate region; other site 471857004482 putative PBP binding loops; other site 471857004483 ABC-ATPase subunit interface; other site 471857004484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857004485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857004486 ABC-ATPase subunit interface; other site 471857004487 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857004488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471857004489 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857004490 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471857004491 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471857004492 putative substrate binding site [chemical binding]; other site 471857004493 putative ATP binding site [chemical binding]; other site 471857004494 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857004495 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 471857004496 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471857004497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004499 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 471857004500 classical (c) SDRs; Region: SDR_c; cd05233 471857004501 NAD(P) binding site [chemical binding]; other site 471857004502 active site 471857004503 classical (c) SDRs; Region: SDR_c; cd05233 471857004504 NAD(P) binding site [chemical binding]; other site 471857004505 active site 471857004506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004508 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004509 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004510 active site 471857004511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004512 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 471857004513 FAD binding site [chemical binding]; other site 471857004514 substrate binding site [chemical binding]; other site 471857004515 catalytic base [active] 471857004516 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004518 active site 471857004519 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 471857004520 Phosphotransferase enzyme family; Region: APH; pfam01636 471857004521 putative active site [active] 471857004522 putative substrate binding site [chemical binding]; other site 471857004523 ATP binding site [chemical binding]; other site 471857004524 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 471857004525 putative active site [active] 471857004526 putative catalytic site [active] 471857004527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471857004528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004529 NAD(P) binding site [chemical binding]; other site 471857004530 active site 471857004531 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 471857004532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471857004533 HSP70 interaction site [polypeptide binding]; other site 471857004534 Nuclease-related domain; Region: NERD; pfam08378 471857004535 Conserved TM helix; Region: TM_helix; pfam05552 471857004536 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857004537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857004538 active site 471857004539 ATP binding site [chemical binding]; other site 471857004540 substrate binding site [chemical binding]; other site 471857004541 activation loop (A-loop); other site 471857004542 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 471857004543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857004544 active site 471857004545 metal binding site [ion binding]; metal-binding site 471857004546 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471857004547 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857004548 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 471857004549 NAD(P) binding site [chemical binding]; other site 471857004550 catalytic residues [active] 471857004551 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471857004552 substrate binding site [chemical binding]; other site 471857004553 selenophosphate synthetase; Provisional; Region: PRK00943 471857004554 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 471857004555 dimerization interface [polypeptide binding]; other site 471857004556 putative ATP binding site [chemical binding]; other site 471857004557 selenocysteine synthase; Provisional; Region: PRK04311 471857004558 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 471857004559 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857004560 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 471857004561 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 471857004562 G1 box; other site 471857004563 putative GEF interaction site [polypeptide binding]; other site 471857004564 GTP/Mg2+ binding site [chemical binding]; other site 471857004565 Switch I region; other site 471857004566 G2 box; other site 471857004567 G3 box; other site 471857004568 Switch II region; other site 471857004569 G4 box; other site 471857004570 G5 box; other site 471857004571 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 471857004572 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 471857004573 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 471857004574 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857004575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471857004576 catalytic residues [active] 471857004577 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471857004578 nudix motif; other site 471857004579 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 471857004580 Zn binding site [ion binding]; other site 471857004581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857004582 PGAP1-like protein; Region: PGAP1; pfam07819 471857004583 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471857004584 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471857004585 Walker A/P-loop; other site 471857004586 ATP binding site [chemical binding]; other site 471857004587 Q-loop/lid; other site 471857004588 ABC transporter signature motif; other site 471857004589 Walker B; other site 471857004590 D-loop; other site 471857004591 H-loop/switch region; other site 471857004592 MarR family; Region: MarR; pfam01047 471857004593 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471857004594 hydrophobic ligand binding site; other site 471857004595 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471857004596 nucleotide binding site/active site [active] 471857004597 HIT family signature motif; other site 471857004598 catalytic residue [active] 471857004599 Lsr2; Region: Lsr2; pfam11774 471857004600 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857004601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857004602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857004603 catalytic residue [active] 471857004604 hypothetical protein; Provisional; Region: PRK07906 471857004605 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471857004606 putative metal binding site [ion binding]; other site 471857004607 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 471857004608 Beta protein; Region: Beta_protein; pfam14350 471857004609 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 471857004610 pentamer interface [polypeptide binding]; other site 471857004611 dodecaamer interface [polypeptide binding]; other site 471857004612 Uncharacterized conserved protein [Function unknown]; Region: COG1739 471857004613 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471857004614 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471857004615 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 471857004616 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471857004617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471857004618 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 471857004619 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 471857004620 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857004621 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857004622 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471857004623 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471857004624 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 471857004625 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471857004626 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 471857004627 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 471857004628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 471857004629 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 471857004630 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 471857004631 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 471857004632 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 471857004633 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471857004634 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 471857004635 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471857004636 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857004637 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471857004638 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857004639 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 471857004640 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471857004641 helicase Cas3; Provisional; Region: PRK09694 471857004642 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 471857004643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471857004644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471857004645 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 471857004646 AAA domain; Region: AAA_33; pfam13671 471857004647 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857004648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857004649 non-specific DNA binding site [nucleotide binding]; other site 471857004650 salt bridge; other site 471857004651 sequence-specific DNA binding site [nucleotide binding]; other site 471857004652 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 471857004653 homodimer interface [polypeptide binding]; other site 471857004654 homotetramer interface [polypeptide binding]; other site 471857004655 active site pocket [active] 471857004656 cleavage site 471857004657 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857004658 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 471857004659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471857004660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471857004661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004663 active site 471857004664 FOG: CBS domain [General function prediction only]; Region: COG0517 471857004665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471857004666 Protoglobin; Region: Protoglobin; pfam11563 471857004667 Amidase; Region: Amidase; cl11426 471857004668 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 471857004669 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 471857004670 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 471857004671 acyl-activating enzyme (AAE) consensus motif; other site 471857004672 active site 471857004673 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 471857004674 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857004675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857004676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857004677 acyl-activating enzyme (AAE) consensus motif; other site 471857004678 acyl-activating enzyme (AAE) consensus motif; other site 471857004679 AMP binding site [chemical binding]; other site 471857004680 active site 471857004681 CoA binding site [chemical binding]; other site 471857004682 DoxX-like family; Region: DoxX_2; pfam13564 471857004683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004684 NAD(P) binding site [chemical binding]; other site 471857004685 active site 471857004686 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 471857004687 active site 471857004688 SAM binding site [chemical binding]; other site 471857004689 homodimer interface [polypeptide binding]; other site 471857004690 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 471857004691 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 471857004692 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 471857004693 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 471857004694 dimer interface [polypeptide binding]; other site 471857004695 [2Fe-2S] cluster binding site [ion binding]; other site 471857004696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857004697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857004698 Walker A/P-loop; other site 471857004699 ATP binding site [chemical binding]; other site 471857004700 Q-loop/lid; other site 471857004701 ABC transporter signature motif; other site 471857004702 Walker B; other site 471857004703 D-loop; other site 471857004704 H-loop/switch region; other site 471857004705 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857004706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857004707 dimer interface [polypeptide binding]; other site 471857004708 putative PBP binding regions; other site 471857004709 ABC-ATPase subunit interface; other site 471857004710 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857004711 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 471857004712 intersubunit interface [polypeptide binding]; other site 471857004713 precorrin-3B synthase; Region: CobG; TIGR02435 471857004714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857004715 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 471857004716 Precorrin-8X methylmutase; Region: CbiC; pfam02570 471857004717 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 471857004718 active site 471857004719 SAM binding site [chemical binding]; other site 471857004720 homodimer interface [polypeptide binding]; other site 471857004721 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 471857004722 active site 471857004723 SAM binding site [chemical binding]; other site 471857004724 homodimer interface [polypeptide binding]; other site 471857004725 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 471857004726 active site 471857004727 SAM binding site [chemical binding]; other site 471857004728 homodimer interface [polypeptide binding]; other site 471857004729 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 471857004730 active site 471857004731 putative homodimer interface [polypeptide binding]; other site 471857004732 SAM binding site [chemical binding]; other site 471857004733 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 471857004734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857004735 S-adenosylmethionine binding site [chemical binding]; other site 471857004736 cobyric acid synthase; Provisional; Region: PRK00784 471857004737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857004738 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471857004739 catalytic triad [active] 471857004740 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 471857004741 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 471857004742 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471857004743 active site 471857004744 SAM binding site [chemical binding]; other site 471857004745 homodimer interface [polypeptide binding]; other site 471857004746 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471857004747 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471857004748 catalytic triad [active] 471857004749 hypothetical protein; Provisional; Region: PRK07908 471857004750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857004751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857004752 homodimer interface [polypeptide binding]; other site 471857004753 catalytic residue [active] 471857004754 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 471857004755 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 471857004756 homodimer interface [polypeptide binding]; other site 471857004757 Walker A motif; other site 471857004758 ATP binding site [chemical binding]; other site 471857004759 hydroxycobalamin binding site [chemical binding]; other site 471857004760 Walker B motif; other site 471857004761 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471857004762 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 471857004763 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 471857004764 metal ion-dependent adhesion site (MIDAS); other site 471857004765 putative acetyltransferase; Provisional; Region: PRK03624 471857004766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857004767 Coenzyme A binding pocket [chemical binding]; other site 471857004768 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471857004769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004770 NAD(P) binding site [chemical binding]; other site 471857004771 active site 471857004772 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857004773 Cytochrome P450; Region: p450; cl12078 471857004774 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 471857004775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857004776 catalytic loop [active] 471857004777 iron binding site [ion binding]; other site 471857004778 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471857004779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857004780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857004781 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 471857004782 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857004783 NAD binding site [chemical binding]; other site 471857004784 catalytic residues [active] 471857004785 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 471857004786 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471857004787 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004788 active site 471857004789 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471857004790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857004791 substrate binding site [chemical binding]; other site 471857004792 oxyanion hole (OAH) forming residues; other site 471857004793 trimer interface [polypeptide binding]; other site 471857004794 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 471857004795 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 471857004796 DUF35 OB-fold domain; Region: DUF35; pfam01796 471857004797 lipid-transfer protein; Provisional; Region: PRK08256 471857004798 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 471857004799 active site 471857004800 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004802 active site 471857004803 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 471857004804 Phosphotransferase enzyme family; Region: APH; pfam01636 471857004805 putative active site [active] 471857004806 putative substrate binding site [chemical binding]; other site 471857004807 ATP binding site [chemical binding]; other site 471857004808 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471857004809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004810 NAD(P) binding site [chemical binding]; other site 471857004811 active site 471857004812 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471857004813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004814 NAD(P) binding site [chemical binding]; other site 471857004815 active site 471857004816 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471857004817 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 471857004818 NAD binding site [chemical binding]; other site 471857004819 substrate binding site [chemical binding]; other site 471857004820 catalytic Zn binding site [ion binding]; other site 471857004821 structural Zn binding site [ion binding]; other site 471857004822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004824 EthD domain; Region: EthD; cl17553 471857004825 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471857004826 putative acyltransferase; Provisional; Region: PRK05790 471857004827 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857004828 dimer interface [polypeptide binding]; other site 471857004829 active site 471857004830 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471857004831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857004832 substrate binding site [chemical binding]; other site 471857004833 oxyanion hole (OAH) forming residues; other site 471857004834 trimer interface [polypeptide binding]; other site 471857004835 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471857004836 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857004837 substrate binding site [chemical binding]; other site 471857004838 ATP binding site [chemical binding]; other site 471857004839 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857004840 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 471857004841 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471857004842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857004843 DNA-binding site [nucleotide binding]; DNA binding site 471857004844 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857004845 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 471857004846 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471857004847 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857004848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857004849 Walker A/P-loop; other site 471857004850 ATP binding site [chemical binding]; other site 471857004851 Q-loop/lid; other site 471857004852 ABC transporter signature motif; other site 471857004853 Walker B; other site 471857004854 D-loop; other site 471857004855 H-loop/switch region; other site 471857004856 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471857004857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857004858 putative Zn2+ binding site [ion binding]; other site 471857004859 putative DNA binding site [nucleotide binding]; other site 471857004860 dimerization interface [polypeptide binding]; other site 471857004861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857004862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857004863 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 471857004864 putative dimerization interface [polypeptide binding]; other site 471857004865 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 471857004866 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857004867 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471857004868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857004869 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471857004870 DNA binding residues [nucleotide binding] 471857004871 SnoaL-like domain; Region: SnoaL_2; pfam12680 471857004872 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471857004873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857004874 dimer interface [polypeptide binding]; other site 471857004875 conserved gate region; other site 471857004876 ABC-ATPase subunit interface; other site 471857004877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471857004878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471857004879 Walker A/P-loop; other site 471857004880 ATP binding site [chemical binding]; other site 471857004881 Q-loop/lid; other site 471857004882 ABC transporter signature motif; other site 471857004883 Walker B; other site 471857004884 D-loop; other site 471857004885 H-loop/switch region; other site 471857004886 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471857004887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 471857004888 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 471857004889 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 471857004890 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471857004891 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471857004892 trimer interface [polypeptide binding]; other site 471857004893 putative metal binding site [ion binding]; other site 471857004894 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857004895 active site 471857004896 catalytic residues [active] 471857004897 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471857004898 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471857004899 catalytic residues [active] 471857004900 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471857004901 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471857004902 DNA binding residues [nucleotide binding] 471857004903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471857004904 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857004905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004906 putative substrate translocation pore; other site 471857004907 HEAT repeats; Region: HEAT_2; pfam13646 471857004908 SnoaL-like domain; Region: SnoaL_2; pfam12680 471857004909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471857004910 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857004911 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857004912 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857004913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857004914 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857004915 Walker A/P-loop; other site 471857004916 ATP binding site [chemical binding]; other site 471857004917 Q-loop/lid; other site 471857004918 ABC transporter signature motif; other site 471857004919 Walker B; other site 471857004920 D-loop; other site 471857004921 H-loop/switch region; other site 471857004922 acyl-CoA synthetase; Validated; Region: PRK05850 471857004923 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 471857004924 acyl-activating enzyme (AAE) consensus motif; other site 471857004925 active site 471857004926 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004928 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004929 active site 471857004930 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004931 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004932 active site 471857004933 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 471857004934 peptide synthase; Provisional; Region: PRK12467 471857004935 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004936 acyl-activating enzyme (AAE) consensus motif; other site 471857004937 AMP binding site [chemical binding]; other site 471857004938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004941 acyl-activating enzyme (AAE) consensus motif; other site 471857004942 AMP binding site [chemical binding]; other site 471857004943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004944 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004946 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004947 acyl-activating enzyme (AAE) consensus motif; other site 471857004948 AMP binding site [chemical binding]; other site 471857004949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004952 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004953 acyl-activating enzyme (AAE) consensus motif; other site 471857004954 AMP binding site [chemical binding]; other site 471857004955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004956 Condensation domain; Region: Condensation; pfam00668 471857004957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004959 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 471857004960 acyl-activating enzyme (AAE) consensus motif; other site 471857004961 AMP binding site [chemical binding]; other site 471857004962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004963 Condensation domain; Region: Condensation; pfam00668 471857004964 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004965 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004966 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004967 acyl-activating enzyme (AAE) consensus motif; other site 471857004968 AMP binding site [chemical binding]; other site 471857004969 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004970 peptide synthase; Provisional; Region: PRK12467 471857004971 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004972 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004973 acyl-activating enzyme (AAE) consensus motif; other site 471857004974 AMP binding site [chemical binding]; other site 471857004975 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004976 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004977 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004978 acyl-activating enzyme (AAE) consensus motif; other site 471857004979 AMP binding site [chemical binding]; other site 471857004980 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004981 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004982 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004983 acyl-activating enzyme (AAE) consensus motif; other site 471857004984 AMP binding site [chemical binding]; other site 471857004985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004986 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004987 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004988 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 471857004989 acyl-activating enzyme (AAE) consensus motif; other site 471857004990 AMP binding site [chemical binding]; other site 471857004991 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004992 Condensation domain; Region: Condensation; pfam00668 471857004993 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004994 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857004995 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857004996 acyl-activating enzyme (AAE) consensus motif; other site 471857004997 AMP binding site [chemical binding]; other site 471857004998 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857004999 Condensation domain; Region: Condensation; pfam00668 471857005000 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857005001 Condensation domain; Region: Condensation; pfam00668 471857005002 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857005003 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857005004 acyl-activating enzyme (AAE) consensus motif; other site 471857005005 AMP binding site [chemical binding]; other site 471857005006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857005007 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 471857005008 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857005009 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857005010 acyl-activating enzyme (AAE) consensus motif; other site 471857005011 AMP binding site [chemical binding]; other site 471857005012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857005013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 471857005014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471857005015 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 471857005016 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471857005017 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 471857005018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857005019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857005020 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 471857005021 putative dimerization interface [polypeptide binding]; other site 471857005022 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 471857005023 Citrate transporter; Region: CitMHS; pfam03600 471857005024 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 471857005025 Predicted acyl esterases [General function prediction only]; Region: COG2936 471857005026 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857005027 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 471857005028 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857005029 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 471857005030 homodimer interface [polypeptide binding]; other site 471857005031 chemical substrate binding site [chemical binding]; other site 471857005032 oligomer interface [polypeptide binding]; other site 471857005033 metal binding site [ion binding]; metal-binding site 471857005034 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 471857005035 Putative cyclase; Region: Cyclase; pfam04199 471857005036 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 471857005037 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471857005038 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471857005039 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 471857005040 FAD binding pocket [chemical binding]; other site 471857005041 FAD binding motif [chemical binding]; other site 471857005042 phosphate binding motif [ion binding]; other site 471857005043 beta-alpha-beta structure motif; other site 471857005044 NAD(p) ribose binding residues [chemical binding]; other site 471857005045 NAD binding pocket [chemical binding]; other site 471857005046 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471857005047 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 471857005048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857005049 catalytic loop [active] 471857005050 iron binding site [ion binding]; other site 471857005051 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857005052 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857005053 FAD binding domain; Region: FAD_binding_3; pfam01494 471857005054 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 471857005055 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471857005056 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 471857005057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857005058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857005059 active site 471857005060 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 471857005061 putative active site [active] 471857005062 putative substrate binding site [chemical binding]; other site 471857005063 ATP binding site [chemical binding]; other site 471857005064 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 471857005065 classical (c) SDRs; Region: SDR_c; cd05233 471857005066 NAD(P) binding site [chemical binding]; other site 471857005067 active site 471857005068 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 471857005069 apical/protease domain interface [polypeptide binding]; other site 471857005070 substrate binding [chemical binding]; other site 471857005071 dimer interface [polypeptide binding]; other site 471857005072 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471857005073 Peptidase family M28; Region: Peptidase_M28; pfam04389 471857005074 metal binding site [ion binding]; metal-binding site 471857005075 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 471857005076 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471857005077 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471857005078 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857005079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005080 putative substrate translocation pore; other site 471857005081 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857005082 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857005083 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857005084 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 471857005085 [2Fe-2S] cluster binding site [ion binding]; other site 471857005086 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471857005087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857005088 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471857005089 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 471857005090 [2Fe-2S] cluster binding site [ion binding]; other site 471857005091 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 471857005092 putative alpha subunit interface [polypeptide binding]; other site 471857005093 putative active site [active] 471857005094 putative substrate binding site [chemical binding]; other site 471857005095 Fe binding site [ion binding]; other site 471857005096 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 471857005097 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 471857005098 NAD binding site [chemical binding]; other site 471857005099 catalytic Zn binding site [ion binding]; other site 471857005100 substrate binding site [chemical binding]; other site 471857005101 structural Zn binding site [ion binding]; other site 471857005102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857005103 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471857005104 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471857005105 dimer interface [polypeptide binding]; other site 471857005106 active site 471857005107 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471857005108 folate binding site [chemical binding]; other site 471857005109 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 471857005110 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471857005111 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 471857005112 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 471857005113 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 471857005114 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857005115 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471857005116 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471857005117 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471857005118 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857005119 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471857005120 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857005121 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857005122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857005123 DNA-binding site [nucleotide binding]; DNA binding site 471857005124 FCD domain; Region: FCD; pfam07729 471857005125 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 471857005126 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471857005127 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 471857005128 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857005129 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857005130 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857005131 putative active site [active] 471857005132 putative substrate binding site [chemical binding]; other site 471857005133 putative cosubstrate binding site; other site 471857005134 catalytic site [active] 471857005135 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 471857005136 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471857005137 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471857005138 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857005139 DNA binding site [nucleotide binding] 471857005140 active site 471857005141 Int/Topo IB signature motif; other site 471857005142 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 471857005143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857005144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857005145 DNA binding site [nucleotide binding] 471857005146 GAF domain; Region: GAF; pfam01590 471857005147 GAF domain; Region: GAF_2; pfam13185 471857005148 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 471857005149 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 471857005150 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 471857005151 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 471857005152 active site 471857005153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471857005154 MarR family; Region: MarR; pfam01047 471857005155 MarR family; Region: MarR_2; cl17246 471857005156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857005157 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 471857005158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857005159 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857005160 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 471857005161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005162 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857005163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857005164 Domain of unknown function (DUF336); Region: DUF336; pfam03928 471857005165 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471857005166 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471857005167 [4Fe-4S] binding site [ion binding]; other site 471857005168 molybdopterin cofactor binding site; other site 471857005169 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 471857005170 molybdopterin cofactor binding site; other site 471857005171 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 471857005172 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 471857005173 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857005174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005175 putative substrate translocation pore; other site 471857005176 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471857005177 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857005178 homodimer interface [polypeptide binding]; other site 471857005179 substrate-cofactor binding pocket; other site 471857005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857005181 catalytic residue [active] 471857005182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471857005183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471857005184 active site 471857005185 catalytic tetrad [active] 471857005186 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 471857005187 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 471857005188 DCoH dimer interaction site [polypeptide binding]; other site 471857005189 substrate binding site [chemical binding]; other site 471857005190 aromatic arch; other site 471857005191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005193 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857005194 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857005195 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471857005196 active site 471857005197 DNA binding site [nucleotide binding] 471857005198 Int/Topo IB signature motif; other site 471857005199 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 471857005200 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 471857005201 4Fe-4S binding domain; Region: Fer4_6; pfam12837 471857005202 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 471857005203 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471857005204 molybdopterin cofactor binding site; other site 471857005205 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471857005206 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471857005207 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471857005208 molybdopterin cofactor binding site; other site 471857005209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857005210 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 471857005211 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 471857005212 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 471857005213 active site 471857005214 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 471857005215 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 471857005216 putative NAD(P) binding site [chemical binding]; other site 471857005217 active site 471857005218 AAA ATPase domain; Region: AAA_16; pfam13191 471857005219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857005220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857005221 DNA binding residues [nucleotide binding] 471857005222 dimerization interface [polypeptide binding]; other site 471857005223 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471857005224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857005225 active site 471857005226 metal binding site [ion binding]; metal-binding site 471857005227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005229 Domain of unknown function (DUF385); Region: DUF385; cl04387 471857005230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005231 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857005232 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471857005233 active site 471857005234 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 471857005235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005236 S-adenosylmethionine binding site [chemical binding]; other site 471857005237 YCII-related domain; Region: YCII; cl00999 471857005238 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 471857005239 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 471857005240 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471857005241 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 471857005242 active site 471857005243 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471857005244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005245 putative substrate translocation pore; other site 471857005246 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857005247 Cytochrome P450; Region: p450; cl12078 471857005248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857005249 dimerization interface [polypeptide binding]; other site 471857005250 putative DNA binding site [nucleotide binding]; other site 471857005251 putative Zn2+ binding site [ion binding]; other site 471857005252 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471857005253 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471857005254 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471857005255 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471857005256 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 471857005257 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471857005258 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857005259 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 471857005260 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471857005261 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857005262 DNA binding residues [nucleotide binding] 471857005263 drug binding residues [chemical binding]; other site 471857005264 dimer interface [polypeptide binding]; other site 471857005265 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857005266 active site 471857005267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857005269 putative substrate translocation pore; other site 471857005270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005271 N-acetyltransferase; Region: Acetyltransf_2; cl00949 471857005272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005274 putative substrate translocation pore; other site 471857005275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857005276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857005277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857005278 putative dimerization interface [polypeptide binding]; other site 471857005279 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 471857005280 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 471857005281 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857005282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005283 S-adenosylmethionine binding site [chemical binding]; other site 471857005284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857005285 dimerization interface [polypeptide binding]; other site 471857005286 putative DNA binding site [nucleotide binding]; other site 471857005287 putative Zn2+ binding site [ion binding]; other site 471857005288 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471857005289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471857005290 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471857005291 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 471857005292 active site 471857005293 catalytic residues [active] 471857005294 DNA binding site [nucleotide binding] 471857005295 Int/Topo IB signature motif; other site 471857005296 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857005297 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471857005298 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857005299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857005300 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857005301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857005302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857005303 Amidohydrolase; Region: Amidohydro_4; pfam13147 471857005304 active site 471857005305 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857005306 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 471857005307 putative active site [active] 471857005308 catalytic triad [active] 471857005309 putative dimer interface [polypeptide binding]; other site 471857005310 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 471857005311 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 471857005312 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471857005313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857005314 active site 471857005315 DNA binding site [nucleotide binding] 471857005316 Int/Topo IB signature motif; other site 471857005317 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471857005318 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 471857005319 putative active site [active] 471857005320 catalytic site [active] 471857005321 putative metal binding site [ion binding]; other site 471857005322 putative inner membrane protein; Provisional; Region: PRK11099 471857005323 Sulphur transport; Region: Sulf_transp; pfam04143 471857005324 Sulphur transport; Region: Sulf_transp; pfam04143 471857005325 hypothetical protein; Provisional; Region: PRK11018 471857005326 CPxP motif; other site 471857005327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471857005328 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471857005329 active site 471857005330 catalytic triad [active] 471857005331 oxyanion hole [active] 471857005332 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471857005333 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471857005334 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 471857005335 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471857005336 conserved hypothetical protein; Region: TIGR03843 471857005337 conserved hypothetical protein; Region: TIGR03847 471857005338 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471857005339 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857005340 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471857005341 dimer interface [polypeptide binding]; other site 471857005342 catalytic triad [active] 471857005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005344 S-adenosylmethionine binding site [chemical binding]; other site 471857005345 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 471857005346 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 471857005347 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857005348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857005349 Walker A/P-loop; other site 471857005350 ATP binding site [chemical binding]; other site 471857005351 Q-loop/lid; other site 471857005352 ABC transporter signature motif; other site 471857005353 Walker B; other site 471857005354 D-loop; other site 471857005355 H-loop/switch region; other site 471857005356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857005357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857005358 Walker A/P-loop; other site 471857005359 ATP binding site [chemical binding]; other site 471857005360 Q-loop/lid; other site 471857005361 ABC transporter signature motif; other site 471857005362 Walker B; other site 471857005363 D-loop; other site 471857005364 H-loop/switch region; other site 471857005365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857005366 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 471857005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857005368 dimer interface [polypeptide binding]; other site 471857005369 conserved gate region; other site 471857005370 putative PBP binding loops; other site 471857005371 ABC-ATPase subunit interface; other site 471857005372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857005374 dimer interface [polypeptide binding]; other site 471857005375 conserved gate region; other site 471857005376 putative PBP binding loops; other site 471857005377 ABC-ATPase subunit interface; other site 471857005378 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471857005379 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857005380 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 471857005381 SxDxEG motif; other site 471857005382 active site 471857005383 metal binding site [ion binding]; metal-binding site 471857005384 homopentamer interface [polypeptide binding]; other site 471857005385 hypothetical protein; Provisional; Region: PRK07906 471857005386 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471857005387 putative metal binding site [ion binding]; other site 471857005388 malate dehydrogenase; Provisional; Region: PRK05442 471857005389 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471857005390 NAD(P) binding site [chemical binding]; other site 471857005391 dimer interface [polypeptide binding]; other site 471857005392 malate binding site [chemical binding]; other site 471857005393 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 471857005394 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 471857005395 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 471857005396 active site 471857005397 Zn binding site [ion binding]; other site 471857005398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857005399 catalytic core [active] 471857005400 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 471857005401 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857005402 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471857005403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471857005404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471857005405 active site 471857005406 catalytic tetrad [active] 471857005407 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471857005408 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857005409 FAD binding domain; Region: FAD_binding_4; pfam01565 471857005410 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 471857005411 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857005412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857005413 catalytic loop [active] 471857005414 iron binding site [ion binding]; other site 471857005415 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857005416 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857005417 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471857005418 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857005419 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471857005420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857005421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005422 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857005423 NAD(P) binding site [chemical binding]; other site 471857005424 active site 471857005425 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471857005426 hydrophobic ligand binding site; other site 471857005427 bile acid transporter; Region: bass; TIGR00841 471857005428 Sodium Bile acid symporter family; Region: SBF; pfam01758 471857005429 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 471857005430 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 471857005431 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 471857005432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857005433 putative ADP-binding pocket [chemical binding]; other site 471857005434 Tannase and feruloyl esterase; Region: Tannase; pfam07519 471857005435 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471857005436 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 471857005437 active site 471857005438 DNA binding site [nucleotide binding] 471857005439 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471857005440 DNA binding site [nucleotide binding] 471857005441 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857005442 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 471857005443 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857005444 active site 471857005445 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857005446 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 471857005447 NAD(P) binding site [chemical binding]; other site 471857005448 catalytic residues [active] 471857005449 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471857005450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005452 Predicted flavoprotein [General function prediction only]; Region: COG0431 471857005453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471857005454 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471857005455 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471857005456 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471857005457 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471857005458 PhoD-like phosphatase; Region: PhoD; pfam09423 471857005459 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471857005460 putative active site [active] 471857005461 putative metal binding site [ion binding]; other site 471857005462 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471857005463 heat shock protein 90; Provisional; Region: PRK05218 471857005464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857005465 ATP binding site [chemical binding]; other site 471857005466 Mg2+ binding site [ion binding]; other site 471857005467 G-X-G motif; other site 471857005468 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 471857005469 putative active site [active] 471857005470 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471857005471 SpoOM protein; Region: Spo0M; pfam07070 471857005472 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857005473 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 471857005474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005475 S-adenosylmethionine binding site [chemical binding]; other site 471857005476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857005477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857005478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857005479 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 471857005480 malonyl-CoA binding site [chemical binding]; other site 471857005481 dimer interface [polypeptide binding]; other site 471857005482 active site 471857005483 product binding site; other site 471857005484 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857005485 metal binding site 2 [ion binding]; metal-binding site 471857005486 putative DNA binding helix; other site 471857005487 metal binding site 1 [ion binding]; metal-binding site 471857005488 dimer interface [polypeptide binding]; other site 471857005489 structural Zn2+ binding site [ion binding]; other site 471857005490 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471857005491 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471857005492 tetramer interface [polypeptide binding]; other site 471857005493 heme binding pocket [chemical binding]; other site 471857005494 NADPH binding site [chemical binding]; other site 471857005495 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471857005496 dimer interface [polypeptide binding]; other site 471857005497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857005498 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 471857005499 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857005500 putative NAD(P) binding site [chemical binding]; other site 471857005501 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 471857005502 ArsC family; Region: ArsC; pfam03960 471857005503 catalytic residues [active] 471857005504 CRISPR-associated protein; Region: TIGR03986 471857005505 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 471857005506 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 471857005507 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 471857005508 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 471857005509 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 471857005510 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 471857005511 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 471857005512 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857005513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857005514 non-specific DNA binding site [nucleotide binding]; other site 471857005515 salt bridge; other site 471857005516 sequence-specific DNA binding site [nucleotide binding]; other site 471857005517 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857005518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857005519 non-specific DNA binding site [nucleotide binding]; other site 471857005520 salt bridge; other site 471857005521 sequence-specific DNA binding site [nucleotide binding]; other site 471857005522 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471857005523 active site 471857005524 NTP binding site [chemical binding]; other site 471857005525 metal binding triad [ion binding]; metal-binding site 471857005526 antibiotic binding site [chemical binding]; other site 471857005527 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 471857005528 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 471857005529 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471857005530 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 471857005531 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471857005532 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471857005533 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 471857005534 Cupin domain; Region: Cupin_2; pfam07883 471857005535 Cupin domain; Region: Cupin_2; pfam07883 471857005536 salicylate hydroxylase; Provisional; Region: PRK08163 471857005537 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857005538 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857005539 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 471857005540 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857005541 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857005542 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471857005543 OsmC-like protein; Region: OsmC; pfam02566 471857005544 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471857005545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005546 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 471857005547 NAD(P) binding site [chemical binding]; other site 471857005548 active site 471857005549 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857005550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005551 putative substrate translocation pore; other site 471857005552 Condensation domain; Region: Condensation; pfam00668 471857005553 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857005554 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857005555 acyl-activating enzyme (AAE) consensus motif; other site 471857005556 AMP binding site [chemical binding]; other site 471857005557 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857005558 Condensation domain; Region: Condensation; pfam00668 471857005559 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857005560 Condensation domain; Region: Condensation; pfam00668 471857005561 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857005562 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 471857005563 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471857005564 acyl-activating enzyme (AAE) consensus motif; other site 471857005565 AMP binding site [chemical binding]; other site 471857005566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471857005567 Condensation domain; Region: Condensation; pfam00668 471857005568 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857005569 Condensation domain; Region: Condensation; pfam00668 471857005570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857005571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857005572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857005573 Walker A/P-loop; other site 471857005574 ATP binding site [chemical binding]; other site 471857005575 Q-loop/lid; other site 471857005576 ABC transporter signature motif; other site 471857005577 Walker B; other site 471857005578 D-loop; other site 471857005579 H-loop/switch region; other site 471857005580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005581 ABC-ATPase subunit interface; other site 471857005582 dimer interface [polypeptide binding]; other site 471857005583 putative PBP binding regions; other site 471857005584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471857005585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005586 ABC-ATPase subunit interface; other site 471857005587 dimer interface [polypeptide binding]; other site 471857005588 putative PBP binding regions; other site 471857005589 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857005590 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857005591 intersubunit interface [polypeptide binding]; other site 471857005592 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471857005593 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857005594 FAD binding pocket [chemical binding]; other site 471857005595 FAD binding motif [chemical binding]; other site 471857005596 phosphate binding motif [ion binding]; other site 471857005597 NAD binding pocket [chemical binding]; other site 471857005598 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 471857005599 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 471857005600 Isochorismatase family; Region: Isochorismatase; pfam00857 471857005601 catalytic triad [active] 471857005602 conserved cis-peptide bond; other site 471857005603 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 471857005604 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 471857005605 acyl-activating enzyme (AAE) consensus motif; other site 471857005606 active site 471857005607 AMP binding site [chemical binding]; other site 471857005608 substrate binding site [chemical binding]; other site 471857005609 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471857005610 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471857005611 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857005612 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 471857005613 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857005614 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 471857005615 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857005616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857005617 catalytic loop [active] 471857005618 iron binding site [ion binding]; other site 471857005619 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857005620 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857005621 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471857005622 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857005623 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 471857005624 putative hydrophobic ligand binding site [chemical binding]; other site 471857005625 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 471857005626 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471857005627 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 471857005628 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471857005629 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 471857005630 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 471857005631 amidase; Provisional; Region: PRK07486 471857005632 Amidase; Region: Amidase; pfam01425 471857005633 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471857005634 active site 471857005635 metal binding site [ion binding]; metal-binding site 471857005636 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857005637 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005638 active site 471857005639 metal binding site [ion binding]; metal-binding site 471857005640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005642 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471857005643 Amidase; Region: Amidase; cl11426 471857005644 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857005645 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471857005646 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471857005647 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 471857005648 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 471857005649 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471857005650 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471857005651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857005652 catalytic residue [active] 471857005653 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857005654 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471857005655 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471857005656 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471857005657 tetramer interface [polypeptide binding]; other site 471857005658 heme binding pocket [chemical binding]; other site 471857005659 NADPH binding site [chemical binding]; other site 471857005660 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857005661 metal binding site 2 [ion binding]; metal-binding site 471857005662 putative DNA binding helix; other site 471857005663 metal binding site 1 [ion binding]; metal-binding site 471857005664 dimer interface [polypeptide binding]; other site 471857005665 structural Zn2+ binding site [ion binding]; other site 471857005666 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857005667 Tetratricopeptide repeat; Region: TPR_10; cl17452 471857005668 CHAT domain; Region: CHAT; pfam12770 471857005669 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 471857005670 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 471857005671 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 471857005672 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 471857005673 Trehalose utilisation; Region: ThuA; pfam06283 471857005674 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857005675 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857005676 FOG: PKD repeat [General function prediction only]; Region: COG3291 471857005677 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471857005678 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 471857005679 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 471857005680 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 471857005681 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 471857005682 catalytic residue [active] 471857005683 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 471857005684 catalytic residues [active] 471857005685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857005686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857005687 peroxiredoxin; Region: AhpC; TIGR03137 471857005688 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471857005689 dimer interface [polypeptide binding]; other site 471857005690 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471857005691 catalytic triad [active] 471857005692 peroxidatic and resolving cysteines [active] 471857005693 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 471857005694 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 471857005695 SnoaL-like domain; Region: SnoaL_2; pfam12680 471857005696 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857005697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471857005698 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 471857005699 putative active site [active] 471857005700 Zn binding site [ion binding]; other site 471857005701 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857005702 metal binding site 2 [ion binding]; metal-binding site 471857005703 putative DNA binding helix; other site 471857005704 metal binding site 1 [ion binding]; metal-binding site 471857005705 dimer interface [polypeptide binding]; other site 471857005706 structural Zn2+ binding site [ion binding]; other site 471857005707 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857005708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005709 dimer interface [polypeptide binding]; other site 471857005710 putative PBP binding regions; other site 471857005711 ABC-ATPase subunit interface; other site 471857005712 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857005713 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 471857005714 intersubunit interface [polypeptide binding]; other site 471857005715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857005716 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857005717 Walker A/P-loop; other site 471857005718 ATP binding site [chemical binding]; other site 471857005719 Q-loop/lid; other site 471857005720 ABC transporter signature motif; other site 471857005721 Walker B; other site 471857005722 D-loop; other site 471857005723 H-loop/switch region; other site 471857005724 BioY family; Region: BioY; pfam02632 471857005725 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471857005726 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 471857005727 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857005728 nucleophilic elbow; other site 471857005729 catalytic triad; other site 471857005730 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857005731 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857005732 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 471857005733 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857005734 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 471857005735 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471857005736 tetramer interface [polypeptide binding]; other site 471857005737 TPP-binding site [chemical binding]; other site 471857005738 heterodimer interface [polypeptide binding]; other site 471857005739 phosphorylation loop region [posttranslational modification] 471857005740 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471857005741 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471857005742 alpha subunit interface [polypeptide binding]; other site 471857005743 TPP binding site [chemical binding]; other site 471857005744 heterodimer interface [polypeptide binding]; other site 471857005745 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857005746 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 471857005747 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857005748 E3 interaction surface; other site 471857005749 lipoyl attachment site [posttranslational modification]; other site 471857005750 DoxX-like family; Region: DoxX_2; pfam13564 471857005751 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 471857005752 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857005753 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 471857005754 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 471857005755 amino acid transporter; Region: 2A0306; TIGR00909 471857005756 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471857005757 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 471857005758 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 471857005759 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471857005760 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471857005761 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 471857005762 active site 471857005763 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 471857005764 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 471857005765 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 471857005766 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857005767 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857005768 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 471857005769 active site 471857005770 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471857005771 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 471857005772 catalytic residues [active] 471857005773 catalytic nucleophile [active] 471857005774 Presynaptic Site I dimer interface [polypeptide binding]; other site 471857005775 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 471857005776 Synaptic Flat tetramer interface [polypeptide binding]; other site 471857005777 Synaptic Site I dimer interface [polypeptide binding]; other site 471857005778 DNA binding site [nucleotide binding] 471857005779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471857005780 DNA-binding interface [nucleotide binding]; DNA binding site 471857005781 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471857005782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857005783 Walker A/P-loop; other site 471857005784 ATP binding site [chemical binding]; other site 471857005785 Q-loop/lid; other site 471857005786 ABC transporter signature motif; other site 471857005787 Walker B; other site 471857005788 D-loop; other site 471857005789 H-loop/switch region; other site 471857005790 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 471857005791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471857005792 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 471857005793 amino acid transporter; Region: 2A0306; TIGR00909 471857005794 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471857005795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005796 S-adenosylmethionine binding site [chemical binding]; other site 471857005797 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471857005798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857005799 DNA-binding site [nucleotide binding]; DNA binding site 471857005800 FCD domain; Region: FCD; pfam07729 471857005801 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 471857005802 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 471857005803 acyl-CoA synthetase; Validated; Region: PRK07787 471857005804 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 471857005805 acyl-activating enzyme (AAE) consensus motif; other site 471857005806 active site 471857005807 AMP binding site [chemical binding]; other site 471857005808 CoA binding site [chemical binding]; other site 471857005809 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471857005810 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857005811 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471857005812 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471857005813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857005814 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471857005815 Uncharacterized conserved protein [Function unknown]; Region: COG3189 471857005816 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471857005817 Protein of unknown function (DUF421); Region: DUF421; pfam04239 471857005818 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 471857005819 thymidine kinase; Provisional; Region: PRK04296 471857005820 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471857005821 ATP binding site [chemical binding]; other site 471857005822 Walker A motif; other site 471857005823 Walker B motif; other site 471857005824 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471857005825 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471857005826 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471857005827 Ligand binding site; other site 471857005828 Putative Catalytic site; other site 471857005829 DXD motif; other site 471857005830 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471857005831 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471857005832 putative active site [active] 471857005833 catalytic triad [active] 471857005834 putative dimer interface [polypeptide binding]; other site 471857005835 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471857005836 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471857005837 active site 471857005838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 471857005839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857005840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857005841 Walker A/P-loop; other site 471857005842 ATP binding site [chemical binding]; other site 471857005843 Q-loop/lid; other site 471857005844 ABC transporter signature motif; other site 471857005845 Walker B; other site 471857005846 D-loop; other site 471857005847 H-loop/switch region; other site 471857005848 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471857005849 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471857005850 Walker A/P-loop; other site 471857005851 ATP binding site [chemical binding]; other site 471857005852 Q-loop/lid; other site 471857005853 ABC transporter signature motif; other site 471857005854 Walker B; other site 471857005855 D-loop; other site 471857005856 H-loop/switch region; other site 471857005857 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857005858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857005859 motif II; other site 471857005860 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471857005861 active site 471857005862 catalytic triad [active] 471857005863 oxyanion hole [active] 471857005864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857005865 putative DNA binding site [nucleotide binding]; other site 471857005866 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 471857005867 putative Zn2+ binding site [ion binding]; other site 471857005868 AsnC family; Region: AsnC_trans_reg; pfam01037 471857005869 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471857005870 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471857005871 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 471857005872 active site 471857005873 5'-3' exonuclease; Region: 53EXOc; smart00475 471857005874 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471857005875 active site 471857005876 metal binding site 1 [ion binding]; metal-binding site 471857005877 putative 5' ssDNA interaction site; other site 471857005878 metal binding site 3; metal-binding site 471857005879 metal binding site 2 [ion binding]; metal-binding site 471857005880 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471857005881 putative DNA binding site [nucleotide binding]; other site 471857005882 putative metal binding site [ion binding]; other site 471857005883 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 471857005884 hypothetical protein; Provisional; Region: PRK01346 471857005885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 471857005886 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 471857005887 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 471857005888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857005889 ATP binding site [chemical binding]; other site 471857005890 putative Mg++ binding site [ion binding]; other site 471857005891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857005892 nucleotide binding region [chemical binding]; other site 471857005893 ATP-binding site [chemical binding]; other site 471857005894 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471857005895 diacylglycerol kinase; Reviewed; Region: PRK11914 471857005896 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471857005897 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 471857005898 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 471857005899 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 471857005900 WYL domain; Region: WYL; pfam13280 471857005901 Predicted transcriptional regulator [Transcription]; Region: COG2378 471857005902 WYL domain; Region: WYL; pfam13280 471857005903 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 471857005904 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 471857005905 active site 471857005906 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471857005907 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471857005908 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 471857005909 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 471857005910 MOSC domain; Region: MOSC; pfam03473 471857005911 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 471857005912 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471857005913 active site 471857005914 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 471857005915 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471857005916 active site 471857005917 Pup-like protein; Region: Pup; pfam05639 471857005918 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 471857005919 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471857005920 active site 471857005921 catalytic tetrad [active] 471857005922 proteasome ATPase; Region: pup_AAA; TIGR03689 471857005923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857005924 Walker A motif; other site 471857005925 ATP binding site [chemical binding]; other site 471857005926 Walker B motif; other site 471857005927 arginine finger; other site 471857005928 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471857005929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005930 S-adenosylmethionine binding site [chemical binding]; other site 471857005931 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471857005932 active site 471857005933 putative substrate binding region [chemical binding]; other site 471857005934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471857005935 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 471857005936 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471857005937 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857005938 active site 2 [active] 471857005939 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857005940 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857005941 P-loop; other site 471857005942 Magnesium ion binding site [ion binding]; other site 471857005943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857005944 Magnesium ion binding site [ion binding]; other site 471857005945 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857005946 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471857005947 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 471857005948 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 471857005949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 471857005950 homodimer interface [polypeptide binding]; other site 471857005951 putative metal binding site [ion binding]; other site 471857005952 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857005953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857005954 S-adenosylmethionine binding site [chemical binding]; other site 471857005955 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471857005956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857005957 motif II; other site 471857005958 PAC2 family; Region: PAC2; pfam09754 471857005959 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857005960 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005961 active site 471857005962 metal binding site [ion binding]; metal-binding site 471857005963 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005964 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005965 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 471857005966 active site 471857005967 HIGH motif; other site 471857005968 nucleotide binding site [chemical binding]; other site 471857005969 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005970 active site 471857005971 KMSKS motif; other site 471857005972 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 471857005973 putative tRNA binding surface [nucleotide binding]; other site 471857005974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005976 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857005977 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857005978 Cytochrome P450; Region: p450; cl12078 471857005979 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 471857005980 active site 471857005981 catalytic triad [active] 471857005982 Clp amino terminal domain; Region: Clp_N; pfam02861 471857005983 Clp amino terminal domain; Region: Clp_N; pfam02861 471857005984 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 471857005985 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 471857005986 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 471857005987 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471857005988 ferrochelatase; Reviewed; Region: hemH; PRK00035 471857005989 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471857005990 C-terminal domain interface [polypeptide binding]; other site 471857005991 active site 471857005992 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471857005993 active site 471857005994 N-terminal domain interface [polypeptide binding]; other site 471857005995 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 471857005996 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471857005997 NAD binding site [chemical binding]; other site 471857005998 homotetramer interface [polypeptide binding]; other site 471857005999 homodimer interface [polypeptide binding]; other site 471857006000 substrate binding site [chemical binding]; other site 471857006001 active site 471857006002 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471857006003 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471857006004 NAD(P) binding site [chemical binding]; other site 471857006005 homotetramer interface [polypeptide binding]; other site 471857006006 homodimer interface [polypeptide binding]; other site 471857006007 active site 471857006008 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471857006009 hypothetical protein; Provisional; Region: PRK13685 471857006010 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471857006011 metal ion-dependent adhesion site (MIDAS); other site 471857006012 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471857006013 Protein of unknown function DUF58; Region: DUF58; pfam01882 471857006014 MoxR-like ATPases [General function prediction only]; Region: COG0714 471857006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857006016 Walker A motif; other site 471857006017 ATP binding site [chemical binding]; other site 471857006018 Walker B motif; other site 471857006019 arginine finger; other site 471857006020 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471857006021 GTP binding site; other site 471857006022 aconitate hydratase; Validated; Region: PRK09277 471857006023 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857006024 substrate binding site [chemical binding]; other site 471857006025 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857006026 ligand binding site [chemical binding]; other site 471857006027 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471857006028 substrate binding site [chemical binding]; other site 471857006029 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 471857006030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471857006031 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 471857006032 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 471857006033 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 471857006034 putative active site [active] 471857006035 putative dimer interface [polypeptide binding]; other site 471857006036 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 471857006037 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471857006038 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471857006039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857006040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857006041 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857006042 putative dimerization interface [polypeptide binding]; other site 471857006043 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471857006044 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857006045 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471857006046 NAD(P) binding site [chemical binding]; other site 471857006047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006049 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471857006050 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857006051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857006052 Transporter associated domain; Region: CorC_HlyC; smart01091 471857006053 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857006054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857006055 FOG: CBS domain [General function prediction only]; Region: COG0517 471857006056 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471857006057 DNA binding residues [nucleotide binding] 471857006058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471857006059 putative dimer interface [polypeptide binding]; other site 471857006060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006062 Bifunctional nuclease; Region: DNase-RNase; pfam02577 471857006063 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471857006064 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471857006065 DNA binding residues [nucleotide binding] 471857006066 dimer interface [polypeptide binding]; other site 471857006067 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471857006068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857006069 phosphopeptide binding site; other site 471857006070 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471857006071 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471857006072 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857006073 acyl-activating enzyme (AAE) consensus motif; other site 471857006074 active site 471857006075 AMP binding site [chemical binding]; other site 471857006076 CoA binding site [chemical binding]; other site 471857006077 enoyl-CoA hydratase; Provisional; Region: PRK06142 471857006078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857006079 substrate binding site [chemical binding]; other site 471857006080 oxyanion hole (OAH) forming residues; other site 471857006081 trimer interface [polypeptide binding]; other site 471857006082 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 471857006083 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471857006084 homodimer interface [polypeptide binding]; other site 471857006085 active site 471857006086 SAM binding site [chemical binding]; other site 471857006087 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857006088 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471857006089 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 471857006090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857006091 catalytic residue [active] 471857006092 MFS/sugar transport protein; Region: MFS_2; pfam13347 471857006093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006095 xylose isomerase; Provisional; Region: PRK12677 471857006096 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 471857006097 MarR family; Region: MarR_2; pfam12802 471857006098 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857006099 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857006100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471857006101 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471857006102 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857006103 siderophore binding site; other site 471857006104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857006105 Cytochrome P450; Region: p450; cl12078 471857006106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006108 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 471857006109 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 471857006110 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471857006111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857006112 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857006113 Cytochrome P450; Region: p450; cl12078 471857006114 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471857006115 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 471857006116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471857006117 classical (c) SDRs; Region: SDR_c; cd05233 471857006118 NAD(P) binding site [chemical binding]; other site 471857006119 active site 471857006120 pyruvate dehydrogenase; Provisional; Region: PRK06546 471857006121 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471857006122 PYR/PP interface [polypeptide binding]; other site 471857006123 dimer interface [polypeptide binding]; other site 471857006124 tetramer interface [polypeptide binding]; other site 471857006125 TPP binding site [chemical binding]; other site 471857006126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857006127 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 471857006128 TPP-binding site [chemical binding]; other site 471857006129 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 471857006130 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471857006131 heme-binding site [chemical binding]; other site 471857006132 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 471857006133 FAD binding pocket [chemical binding]; other site 471857006134 FAD binding motif [chemical binding]; other site 471857006135 phosphate binding motif [ion binding]; other site 471857006136 beta-alpha-beta structure motif; other site 471857006137 NAD binding pocket [chemical binding]; other site 471857006138 Heme binding pocket [chemical binding]; other site 471857006139 Rrf2 family protein; Region: rrf2_super; TIGR00738 471857006140 Transcriptional regulator; Region: Rrf2; pfam02082 471857006141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857006142 short chain dehydrogenase; Provisional; Region: PRK08251 471857006143 classical (c) SDRs; Region: SDR_c; cd05233 471857006144 NAD(P) binding site [chemical binding]; other site 471857006145 active site 471857006146 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471857006147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857006148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857006149 active site 471857006150 phosphorylation site [posttranslational modification] 471857006151 intermolecular recognition site; other site 471857006152 dimerization interface [polypeptide binding]; other site 471857006153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857006154 DNA binding residues [nucleotide binding] 471857006155 dimerization interface [polypeptide binding]; other site 471857006156 GAF domain; Region: GAF_2; pfam13185 471857006157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857006158 Histidine kinase; Region: HisKA_3; pfam07730 471857006159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857006160 ATP binding site [chemical binding]; other site 471857006161 Mg2+ binding site [ion binding]; other site 471857006162 G-X-G motif; other site 471857006163 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006164 Ligand Binding Site [chemical binding]; other site 471857006165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006166 Ligand Binding Site [chemical binding]; other site 471857006167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006168 Ligand Binding Site [chemical binding]; other site 471857006169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006170 Ligand Binding Site [chemical binding]; other site 471857006171 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471857006172 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 471857006173 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471857006174 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471857006175 Peptidase family M50; Region: Peptidase_M50; pfam02163 471857006176 active site 471857006177 putative substrate binding region [chemical binding]; other site 471857006178 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006179 Ligand Binding Site [chemical binding]; other site 471857006180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006181 Ligand Binding Site [chemical binding]; other site 471857006182 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471857006183 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471857006184 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471857006185 putative dimer interface [polypeptide binding]; other site 471857006186 Patatin-like phospholipase; Region: Patatin; pfam01734 471857006187 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 471857006188 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857006189 active site 471857006190 HIGH motif; other site 471857006191 nucleotide binding site [chemical binding]; other site 471857006192 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857006193 active site 471857006194 KMSKS motif; other site 471857006195 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857006196 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 471857006197 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 471857006198 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471857006199 TM-ABC transporter signature motif; other site 471857006200 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857006201 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471857006202 TM-ABC transporter signature motif; other site 471857006203 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471857006204 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 471857006205 Walker A/P-loop; other site 471857006206 ATP binding site [chemical binding]; other site 471857006207 Q-loop/lid; other site 471857006208 ABC transporter signature motif; other site 471857006209 Walker B; other site 471857006210 D-loop; other site 471857006211 H-loop/switch region; other site 471857006212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471857006213 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 471857006214 Walker A/P-loop; other site 471857006215 ATP binding site [chemical binding]; other site 471857006216 Q-loop/lid; other site 471857006217 ABC transporter signature motif; other site 471857006218 Walker B; other site 471857006219 D-loop; other site 471857006220 H-loop/switch region; other site 471857006221 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857006222 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 471857006223 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857006224 classical (c) SDRs; Region: SDR_c; cd05233 471857006225 NAD(P) binding site [chemical binding]; other site 471857006226 active site 471857006227 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 471857006228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857006229 FeS/SAM binding site; other site 471857006230 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 471857006231 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471857006232 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 471857006233 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 471857006234 Active site cavity [active] 471857006235 catalytic acid [active] 471857006236 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471857006237 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857006238 substrate binding pocket [chemical binding]; other site 471857006239 chain length determination region; other site 471857006240 substrate-Mg2+ binding site; other site 471857006241 catalytic residues [active] 471857006242 aspartate-rich region 1; other site 471857006243 active site lid residues [active] 471857006244 aspartate-rich region 2; other site 471857006245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857006246 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 471857006247 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857006248 active site lid residues [active] 471857006249 substrate binding pocket [chemical binding]; other site 471857006250 catalytic residues [active] 471857006251 substrate-Mg2+ binding site; other site 471857006252 aspartate-rich region 1; other site 471857006253 aspartate-rich region 2; other site 471857006254 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857006255 active site lid residues [active] 471857006256 substrate binding pocket [chemical binding]; other site 471857006257 catalytic residues [active] 471857006258 substrate-Mg2+ binding site; other site 471857006259 aspartate-rich region 1; other site 471857006260 aspartate-rich region 2; other site 471857006261 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857006262 Ligand Binding Site [chemical binding]; other site 471857006263 MarR family; Region: MarR_2; pfam12802 471857006264 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857006265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857006266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857006267 nucleotide binding site [chemical binding]; other site 471857006268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471857006269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006271 WHG domain; Region: WHG; pfam13305 471857006272 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857006273 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857006274 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857006275 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471857006276 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857006277 carboxyltransferase (CT) interaction site; other site 471857006278 biotinylation site [posttranslational modification]; other site 471857006279 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 471857006280 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471857006281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006282 putative substrate translocation pore; other site 471857006283 PRC-barrel domain; Region: PRC; pfam05239 471857006284 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 471857006285 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 471857006286 hypothetical protein; Reviewed; Region: PRK09588 471857006287 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 471857006288 STAS domain; Region: STAS_2; pfam13466 471857006289 GAF domain; Region: GAF_2; pfam13185 471857006290 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471857006291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857006292 Histidine kinase; Region: HisKA_3; pfam07730 471857006293 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857006294 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 471857006295 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 471857006296 tetramerization interface [polypeptide binding]; other site 471857006297 NAD(P) binding site [chemical binding]; other site 471857006298 catalytic residues [active] 471857006299 BCCT family transporter; Region: BCCT; cl00569 471857006300 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857006301 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 471857006302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857006303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857006304 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 471857006305 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857006306 NAD(P) binding site [chemical binding]; other site 471857006307 Predicted membrane protein [Function unknown]; Region: COG2261 471857006308 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857006309 threonine dehydratase; Validated; Region: PRK08639 471857006310 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857006311 tetramer interface [polypeptide binding]; other site 471857006312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006313 catalytic residue [active] 471857006314 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 471857006315 putative Ile/Val binding site [chemical binding]; other site 471857006316 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471857006317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857006320 putative substrate translocation pore; other site 471857006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006322 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471857006323 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471857006324 dimer interface [polypeptide binding]; other site 471857006325 motif 1; other site 471857006326 active site 471857006327 motif 2; other site 471857006328 motif 3; other site 471857006329 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471857006330 anticodon binding site; other site 471857006331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857006333 dimer interface [polypeptide binding]; other site 471857006334 conserved gate region; other site 471857006335 putative PBP binding loops; other site 471857006336 ABC-ATPase subunit interface; other site 471857006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857006338 dimer interface [polypeptide binding]; other site 471857006339 conserved gate region; other site 471857006340 putative PBP binding loops; other site 471857006341 ABC-ATPase subunit interface; other site 471857006342 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857006343 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471857006344 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857006345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857006346 DNA binding site [nucleotide binding] 471857006347 domain linker motif; other site 471857006348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857006349 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471857006350 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471857006351 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471857006352 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 471857006353 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471857006354 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471857006355 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471857006356 Walker A/P-loop; other site 471857006357 ATP binding site [chemical binding]; other site 471857006358 Q-loop/lid; other site 471857006359 ABC transporter signature motif; other site 471857006360 Walker B; other site 471857006361 D-loop; other site 471857006362 H-loop/switch region; other site 471857006363 NIL domain; Region: NIL; pfam09383 471857006364 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 471857006365 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857006366 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 471857006367 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471857006368 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857006369 active site 1 [active] 471857006370 active site 2 [active] 471857006371 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 471857006372 oligomeric interface; other site 471857006373 putative active site [active] 471857006374 homodimer interface [polypeptide binding]; other site 471857006375 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 471857006376 aspartate aminotransferase; Provisional; Region: PRK05764 471857006377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857006378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006379 homodimer interface [polypeptide binding]; other site 471857006380 catalytic residue [active] 471857006381 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471857006382 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471857006383 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471857006384 putative active site [active] 471857006385 amino acid transporter; Region: 2A0306; TIGR00909 471857006386 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 471857006387 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471857006388 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471857006389 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471857006390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006391 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471857006392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857006393 enoyl-CoA hydratase; Provisional; Region: PRK08252 471857006394 substrate binding site [chemical binding]; other site 471857006395 oxyanion hole (OAH) forming residues; other site 471857006396 trimer interface [polypeptide binding]; other site 471857006397 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857006398 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857006399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857006400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857006401 short chain dehydrogenase; Provisional; Region: PRK08303 471857006402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006403 NAD(P) binding site [chemical binding]; other site 471857006404 active site 471857006405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006406 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857006407 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471857006408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006409 NAD(P) binding site [chemical binding]; other site 471857006410 active site 471857006411 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857006412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006413 non-specific DNA binding site [nucleotide binding]; other site 471857006414 salt bridge; other site 471857006415 sequence-specific DNA binding site [nucleotide binding]; other site 471857006416 Family of unknown function (DUF706); Region: DUF706; pfam05153 471857006417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857006418 Helix-turn-helix domain; Region: HTH_17; pfam12728 471857006419 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 471857006420 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471857006421 Int/Topo IB signature motif; other site 471857006422 aconitate hydratase; Validated; Region: PRK07229 471857006423 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857006424 substrate binding site [chemical binding]; other site 471857006425 ligand binding site [chemical binding]; other site 471857006426 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 471857006427 substrate binding site [chemical binding]; other site 471857006428 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857006429 Beta-lactamase; Region: Beta-lactamase; pfam00144 471857006430 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471857006431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857006432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857006433 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 471857006434 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857006435 inhibitor-cofactor binding pocket; inhibition site 471857006436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006437 catalytic residue [active] 471857006438 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 471857006439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471857006440 Walker A motif; other site 471857006441 ATP binding site [chemical binding]; other site 471857006442 Walker B motif; other site 471857006443 hypothetical protein; Provisional; Region: PRK14059 471857006444 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 471857006445 TAP-like protein; Region: Abhydrolase_4; pfam08386 471857006446 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471857006447 putative catalytic site [active] 471857006448 putative metal binding site [ion binding]; other site 471857006449 putative phosphate binding site [ion binding]; other site 471857006450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857006451 AMP-binding enzyme; Region: AMP-binding; pfam00501 471857006452 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857006453 AMP binding site [chemical binding]; other site 471857006454 Uncharacterized conserved protein [Function unknown]; Region: COG0398 471857006455 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471857006456 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857006457 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857006458 active site 471857006459 ATP binding site [chemical binding]; other site 471857006460 substrate binding site [chemical binding]; other site 471857006461 activation loop (A-loop); other site 471857006462 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471857006463 SelR domain; Region: SelR; pfam01641 471857006464 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 471857006465 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471857006466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857006467 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471857006468 substrate binding site [chemical binding]; other site 471857006469 active site 471857006470 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471857006471 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471857006472 catalytic site [active] 471857006473 putative active site [active] 471857006474 putative substrate binding site [chemical binding]; other site 471857006475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857006476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471857006477 dimerization interface [polypeptide binding]; other site 471857006478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857006479 dimer interface [polypeptide binding]; other site 471857006480 phosphorylation site [posttranslational modification] 471857006481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857006482 ATP binding site [chemical binding]; other site 471857006483 Mg2+ binding site [ion binding]; other site 471857006484 G-X-G motif; other site 471857006485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857006486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857006487 active site 471857006488 phosphorylation site [posttranslational modification] 471857006489 intermolecular recognition site; other site 471857006490 dimerization interface [polypeptide binding]; other site 471857006491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857006492 DNA binding site [nucleotide binding] 471857006493 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471857006494 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471857006495 TPP-binding site; other site 471857006496 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857006497 PYR/PP interface [polypeptide binding]; other site 471857006498 dimer interface [polypeptide binding]; other site 471857006499 TPP binding site [chemical binding]; other site 471857006500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857006501 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471857006502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857006503 DNA-binding site [nucleotide binding]; DNA binding site 471857006504 FCD domain; Region: FCD; pfam07729 471857006505 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471857006506 AAA domain; Region: AAA_33; pfam13671 471857006507 ATP-binding site [chemical binding]; other site 471857006508 Gluconate-6-phosphate binding site [chemical binding]; other site 471857006509 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 471857006510 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471857006511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006513 MMPL family; Region: MMPL; pfam03176 471857006514 MMPL family; Region: MMPL; pfam03176 471857006515 TRAM domain; Region: TRAM; pfam01938 471857006516 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471857006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857006518 S-adenosylmethionine binding site [chemical binding]; other site 471857006519 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471857006520 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471857006521 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471857006522 trimer interface [polypeptide binding]; other site 471857006523 active site 471857006524 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 471857006525 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 471857006526 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471857006527 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471857006528 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471857006529 active site 471857006530 dimerization interface [polypeptide binding]; other site 471857006531 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857006532 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857006533 nucleotide binding site [chemical binding]; other site 471857006534 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857006535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857006536 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857006537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857006538 DNA binding residues [nucleotide binding] 471857006539 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471857006540 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857006541 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471857006542 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857006543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857006544 nucleotide binding site [chemical binding]; other site 471857006545 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471857006546 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857006547 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471857006548 TM-ABC transporter signature motif; other site 471857006549 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471857006550 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471857006551 Walker A/P-loop; other site 471857006552 ATP binding site [chemical binding]; other site 471857006553 Q-loop/lid; other site 471857006554 ABC transporter signature motif; other site 471857006555 Walker B; other site 471857006556 D-loop; other site 471857006557 H-loop/switch region; other site 471857006558 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471857006559 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471857006560 putative ligand binding site [chemical binding]; other site 471857006561 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471857006562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857006563 ATP binding site [chemical binding]; other site 471857006564 putative Mg++ binding site [ion binding]; other site 471857006565 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 471857006566 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471857006567 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 471857006568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857006569 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857006570 substrate binding site [chemical binding]; other site 471857006571 ATP binding site [chemical binding]; other site 471857006572 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471857006573 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 471857006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857006575 S-adenosylmethionine binding site [chemical binding]; other site 471857006576 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471857006577 putative active site [active] 471857006578 dimerization interface [polypeptide binding]; other site 471857006579 putative tRNAtyr binding site [nucleotide binding]; other site 471857006580 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857006581 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471857006582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857006583 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857006584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857006585 DNA binding residues [nucleotide binding] 471857006586 fumarate hydratase; Provisional; Region: PRK15389 471857006587 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 471857006588 Fumarase C-terminus; Region: Fumerase_C; pfam05683 471857006589 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 471857006590 putative active site [active] 471857006591 putative metal binding site [ion binding]; other site 471857006592 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 471857006593 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 471857006594 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471857006595 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857006596 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471857006597 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857006598 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471857006599 B12 binding site [chemical binding]; other site 471857006600 cobalt ligand [ion binding]; other site 471857006601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857006602 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 471857006603 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 471857006604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471857006605 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857006606 G1 box; other site 471857006607 GTP/Mg2+ binding site [chemical binding]; other site 471857006608 G2 box; other site 471857006609 Switch I region; other site 471857006610 G3 box; other site 471857006611 Switch II region; other site 471857006612 G4 box; other site 471857006613 G5 box; other site 471857006614 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857006615 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857006616 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857006617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857006618 HAMP domain; Region: HAMP; pfam00672 471857006619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857006620 ATP binding site [chemical binding]; other site 471857006621 Mg2+ binding site [ion binding]; other site 471857006622 G-X-G motif; other site 471857006623 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471857006624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 471857006625 dimer interface [polypeptide binding]; other site 471857006626 active site 471857006627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857006628 catalytic residues [active] 471857006629 substrate binding site [chemical binding]; other site 471857006630 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 471857006631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857006632 S-adenosylmethionine binding site [chemical binding]; other site 471857006633 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 471857006634 Glucitol operon activator protein (GutM); Region: GutM; cl01890 471857006635 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 471857006636 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471857006637 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857006638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471857006639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857006640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857006641 active site 471857006642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006644 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 471857006645 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 471857006646 NAD(P) binding site [chemical binding]; other site 471857006647 catalytic residues [active] 471857006648 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857006649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006650 sequence-specific DNA binding site [nucleotide binding]; other site 471857006651 salt bridge; other site 471857006652 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471857006653 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471857006654 active site 471857006655 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471857006656 catalytic triad [active] 471857006657 dimer interface [polypeptide binding]; other site 471857006658 pyruvate kinase; Provisional; Region: PRK06247 471857006659 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 471857006660 domain interfaces; other site 471857006661 active site 471857006662 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 471857006663 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471857006664 transmembrane helices; other site 471857006665 phosphofructokinase; Region: PFK_mixed; TIGR02483 471857006666 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 471857006667 active site 471857006668 ADP/pyrophosphate binding site [chemical binding]; other site 471857006669 dimerization interface [polypeptide binding]; other site 471857006670 allosteric effector site; other site 471857006671 fructose-1,6-bisphosphate binding site; other site 471857006672 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 471857006673 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471857006674 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857006675 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857006676 putative acyl-acceptor binding pocket; other site 471857006677 Esterase/lipase [General function prediction only]; Region: COG1647 471857006678 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471857006679 nudix motif; other site 471857006680 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471857006681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857006682 nucleotide binding site [chemical binding]; other site 471857006683 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857006684 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 471857006685 DTAP/Switch II; other site 471857006686 Switch I; other site 471857006687 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 471857006688 putative hydrophobic ligand binding site [chemical binding]; other site 471857006689 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857006690 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857006691 active site 471857006692 metal binding site [ion binding]; metal-binding site 471857006693 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471857006694 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471857006695 acyl-activating enzyme (AAE) consensus motif; other site 471857006696 putative AMP binding site [chemical binding]; other site 471857006697 putative active site [active] 471857006698 putative CoA binding site [chemical binding]; other site 471857006699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857006700 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857006701 Walker A/P-loop; other site 471857006702 ATP binding site [chemical binding]; other site 471857006703 Q-loop/lid; other site 471857006704 ABC transporter signature motif; other site 471857006705 Walker B; other site 471857006706 D-loop; other site 471857006707 H-loop/switch region; other site 471857006708 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857006709 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857006710 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471857006711 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471857006712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471857006713 Septum formation initiator; Region: DivIC; cl17659 471857006714 MraW methylase family; Region: Methyltransf_5; cl17771 471857006715 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471857006716 cell division protein MraZ; Reviewed; Region: PRK00326 471857006717 MraZ protein; Region: MraZ; pfam02381 471857006718 MraZ protein; Region: MraZ; pfam02381 471857006719 EspG family; Region: ESX-1_EspG; pfam14011 471857006720 MoxR-like ATPases [General function prediction only]; Region: COG0714 471857006721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857006722 Walker A motif; other site 471857006723 ATP binding site [chemical binding]; other site 471857006724 Walker B motif; other site 471857006725 arginine finger; other site 471857006726 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471857006727 Protein of unknown function DUF58; Region: DUF58; pfam01882 471857006728 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471857006729 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471857006730 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857006731 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471857006732 active site 471857006733 DNA polymerase IV; Validated; Region: PRK02406 471857006734 DNA binding site [nucleotide binding] 471857006735 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857006736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857006737 S-adenosylmethionine binding site [chemical binding]; other site 471857006738 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857006739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857006740 P-loop; other site 471857006741 Magnesium ion binding site [ion binding]; other site 471857006742 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857006743 Magnesium ion binding site [ion binding]; other site 471857006744 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 471857006745 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 471857006746 quinone interaction residues [chemical binding]; other site 471857006747 active site 471857006748 catalytic residues [active] 471857006749 FMN binding site [chemical binding]; other site 471857006750 substrate binding site [chemical binding]; other site 471857006751 Amidase; Region: Amidase; cl11426 471857006752 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 471857006753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006754 non-specific DNA binding site [nucleotide binding]; other site 471857006755 salt bridge; other site 471857006756 sequence-specific DNA binding site [nucleotide binding]; other site 471857006757 Competence-damaged protein; Region: CinA; pfam02464 471857006758 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471857006759 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 471857006760 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471857006761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857006762 FeS/SAM binding site; other site 471857006763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857006764 Coenzyme A binding pocket [chemical binding]; other site 471857006765 O-succinylbenzoate synthase; Provisional; Region: PRK02901 471857006766 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 471857006767 active site 471857006768 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471857006769 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857006770 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471857006771 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857006772 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857006773 putative acyl-acceptor binding pocket; other site 471857006774 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471857006775 EamA-like transporter family; Region: EamA; pfam00892 471857006776 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471857006777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857006778 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471857006779 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471857006780 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471857006781 dimer interface [polypeptide binding]; other site 471857006782 active site 471857006783 catalytic residue [active] 471857006784 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857006785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857006786 active site 471857006787 ATP binding site [chemical binding]; other site 471857006788 substrate binding site [chemical binding]; other site 471857006789 activation loop (A-loop); other site 471857006790 Septum formation; Region: Septum_form; pfam13845 471857006791 Uncharacterized conserved protein [Function unknown]; Region: COG3603 471857006792 Family description; Region: ACT_7; pfam13840 471857006793 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 471857006794 HicB family; Region: HicB; pfam05534 471857006795 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471857006796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 471857006797 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471857006798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471857006799 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471857006800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857006801 RNA binding surface [nucleotide binding]; other site 471857006802 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471857006803 active site 471857006804 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 471857006805 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 471857006806 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857006807 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857006808 P-loop; other site 471857006809 Magnesium ion binding site [ion binding]; other site 471857006810 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857006811 Magnesium ion binding site [ion binding]; other site 471857006812 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471857006813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857006814 active site 471857006815 DNA binding site [nucleotide binding] 471857006816 Int/Topo IB signature motif; other site 471857006817 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 471857006818 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857006819 TM2 domain; Region: TM2; pfam05154 471857006820 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471857006821 dimer interface [polypeptide binding]; other site 471857006822 active site 471857006823 ADP-ribose binding site [chemical binding]; other site 471857006824 nudix motif; other site 471857006825 metal binding site [ion binding]; metal-binding site 471857006826 CTP synthetase; Validated; Region: pyrG; PRK05380 471857006827 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471857006828 Catalytic site [active] 471857006829 active site 471857006830 UTP binding site [chemical binding]; other site 471857006831 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471857006832 active site 471857006833 putative oxyanion hole; other site 471857006834 catalytic triad [active] 471857006835 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471857006836 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471857006837 hinge; other site 471857006838 active site 471857006839 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 471857006840 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 471857006841 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471857006842 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471857006843 Walker A/P-loop; other site 471857006844 ATP binding site [chemical binding]; other site 471857006845 Q-loop/lid; other site 471857006846 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471857006847 ABC transporter signature motif; other site 471857006848 Walker B; other site 471857006849 D-loop; other site 471857006850 H-loop/switch region; other site 471857006851 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 471857006852 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471857006853 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471857006854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857006855 RNA binding surface [nucleotide binding]; other site 471857006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857006857 S-adenosylmethionine binding site [chemical binding]; other site 471857006858 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471857006859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857006860 active site 471857006861 motif I; other site 471857006862 motif II; other site 471857006863 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471857006864 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471857006865 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471857006866 active site 471857006867 HIGH motif; other site 471857006868 dimer interface [polypeptide binding]; other site 471857006869 KMSKS motif; other site 471857006870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857006871 RNA binding surface [nucleotide binding]; other site 471857006872 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471857006873 active site 471857006874 DNA binding site [nucleotide binding] 471857006875 argininosuccinate lyase; Provisional; Region: PRK00855 471857006876 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471857006877 active sites [active] 471857006878 tetramer interface [polypeptide binding]; other site 471857006879 argininosuccinate synthase; Provisional; Region: PRK13820 471857006880 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471857006881 ANP binding site [chemical binding]; other site 471857006882 Substrate Binding Site II [chemical binding]; other site 471857006883 Substrate Binding Site I [chemical binding]; other site 471857006884 arginine repressor; Provisional; Region: PRK03341 471857006885 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471857006886 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471857006887 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471857006888 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471857006889 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471857006890 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471857006891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857006892 inhibitor-cofactor binding pocket; inhibition site 471857006893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006894 catalytic residue [active] 471857006895 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 471857006896 feedback inhibition sensing region; other site 471857006897 homohexameric interface [polypeptide binding]; other site 471857006898 nucleotide binding site [chemical binding]; other site 471857006899 N-acetyl-L-glutamate binding site [chemical binding]; other site 471857006900 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471857006901 heterotetramer interface [polypeptide binding]; other site 471857006902 active site pocket [active] 471857006903 cleavage site 471857006904 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471857006905 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471857006906 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471857006907 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471857006908 putative tRNA-binding site [nucleotide binding]; other site 471857006909 B3/4 domain; Region: B3_4; pfam03483 471857006910 tRNA synthetase B5 domain; Region: B5; smart00874 471857006911 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471857006912 dimer interface [polypeptide binding]; other site 471857006913 motif 1; other site 471857006914 motif 3; other site 471857006915 motif 2; other site 471857006916 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471857006917 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471857006918 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471857006919 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471857006920 dimer interface [polypeptide binding]; other site 471857006921 motif 1; other site 471857006922 active site 471857006923 motif 2; other site 471857006924 motif 3; other site 471857006925 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471857006926 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471857006927 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471857006928 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471857006929 23S rRNA binding site [nucleotide binding]; other site 471857006930 L21 binding site [polypeptide binding]; other site 471857006931 L13 binding site [polypeptide binding]; other site 471857006932 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471857006933 translation initiation factor IF-3; Region: infC; TIGR00168 471857006934 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471857006935 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471857006936 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471857006937 homotrimer interaction site [polypeptide binding]; other site 471857006938 putative active site [active] 471857006939 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471857006940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857006941 active site 471857006942 phosphorylation site [posttranslational modification] 471857006943 intermolecular recognition site; other site 471857006944 dimerization interface [polypeptide binding]; other site 471857006945 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471857006946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857006947 ATP binding site [chemical binding]; other site 471857006948 Mg2+ binding site [ion binding]; other site 471857006949 G-X-G motif; other site 471857006950 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471857006951 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471857006952 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471857006953 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471857006954 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471857006955 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471857006956 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857006957 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857006958 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471857006959 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471857006960 nudix motif; other site 471857006961 Helix-turn-helix domain; Region: HTH_17; cl17695 471857006962 RES domain; Region: RES; pfam08808 471857006963 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471857006964 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857006965 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 471857006966 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471857006967 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857006968 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471857006969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857006970 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471857006971 Walker A/P-loop; other site 471857006972 ATP binding site [chemical binding]; other site 471857006973 Q-loop/lid; other site 471857006974 ABC transporter signature motif; other site 471857006975 Walker B; other site 471857006976 D-loop; other site 471857006977 H-loop/switch region; other site 471857006978 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471857006979 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471857006980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857006981 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857006982 excinuclease ABC subunit B; Provisional; Region: PRK05298 471857006983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857006984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857006985 nucleotide binding region [chemical binding]; other site 471857006986 ATP-binding site [chemical binding]; other site 471857006987 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471857006988 UvrB/uvrC motif; Region: UVR; pfam02151 471857006989 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 471857006990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857006991 dimerization interface [polypeptide binding]; other site 471857006992 putative DNA binding site [nucleotide binding]; other site 471857006993 putative Zn2+ binding site [ion binding]; other site 471857006994 Protein of unknown function (DUF402); Region: DUF402; cl00979 471857006995 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 471857006996 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471857006997 CoA-binding site [chemical binding]; other site 471857006998 ATP-binding [chemical binding]; other site 471857006999 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471857007000 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471857007001 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471857007002 RNA binding site [nucleotide binding]; other site 471857007003 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471857007004 RNA binding site [nucleotide binding]; other site 471857007005 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471857007006 RNA binding site [nucleotide binding]; other site 471857007007 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 471857007008 RNA binding site [nucleotide binding]; other site 471857007009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007010 S-adenosylmethionine binding site [chemical binding]; other site 471857007011 short chain dehydrogenase; Provisional; Region: PRK08309 471857007012 DNA polymerase I; Provisional; Region: PRK05755 471857007013 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471857007014 active site 471857007015 metal binding site 1 [ion binding]; metal-binding site 471857007016 putative 5' ssDNA interaction site; other site 471857007017 metal binding site 3; metal-binding site 471857007018 metal binding site 2 [ion binding]; metal-binding site 471857007019 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471857007020 putative DNA binding site [nucleotide binding]; other site 471857007021 putative metal binding site [ion binding]; other site 471857007022 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471857007023 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471857007024 active site 471857007025 DNA binding site [nucleotide binding] 471857007026 catalytic site [active] 471857007027 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857007028 CoenzymeA binding site [chemical binding]; other site 471857007029 subunit interaction site [polypeptide binding]; other site 471857007030 PHB binding site; other site 471857007031 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471857007032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857007033 active site 471857007034 phosphorylation site [posttranslational modification] 471857007035 intermolecular recognition site; other site 471857007036 dimerization interface [polypeptide binding]; other site 471857007037 ANTAR domain; Region: ANTAR; pfam03861 471857007038 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 471857007039 substrate binding pocket [chemical binding]; other site 471857007040 catalytic residues [active] 471857007041 benzoate transport; Region: 2A0115; TIGR00895 471857007042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007044 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471857007045 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 471857007046 FMN-binding pocket [chemical binding]; other site 471857007047 flavin binding motif; other site 471857007048 phosphate binding motif [ion binding]; other site 471857007049 beta-alpha-beta structure motif; other site 471857007050 NAD binding pocket [chemical binding]; other site 471857007051 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857007052 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 471857007053 catalytic loop [active] 471857007054 iron binding site [ion binding]; other site 471857007055 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 471857007056 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471857007057 iron-sulfur cluster [ion binding]; other site 471857007058 [2Fe-2S] cluster binding site [ion binding]; other site 471857007059 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 471857007060 alpha subunit interface [polypeptide binding]; other site 471857007061 active site 471857007062 substrate binding site [chemical binding]; other site 471857007063 Fe binding site [ion binding]; other site 471857007064 Predicted transcriptional regulators [Transcription]; Region: COG1695 471857007065 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471857007066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471857007067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857007068 Coenzyme A binding pocket [chemical binding]; other site 471857007069 YrhK-like protein; Region: YrhK; pfam14145 471857007070 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471857007071 active site 471857007072 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 471857007073 dimer interface [polypeptide binding]; other site 471857007074 non-prolyl cis peptide bond; other site 471857007075 insertion regions; other site 471857007076 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 471857007077 Predicted flavoprotein [General function prediction only]; Region: COG0431 471857007078 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471857007079 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857007080 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857007081 NAD(P) binding site [chemical binding]; other site 471857007082 catalytic residues [active] 471857007083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471857007084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857007085 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471857007086 active site 471857007087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857007088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857007089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471857007090 dimerization interface [polypeptide binding]; other site 471857007091 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 471857007092 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 471857007093 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 471857007094 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471857007095 Walker A/P-loop; other site 471857007096 ATP binding site [chemical binding]; other site 471857007097 Q-loop/lid; other site 471857007098 ABC transporter signature motif; other site 471857007099 Walker B; other site 471857007100 D-loop; other site 471857007101 H-loop/switch region; other site 471857007102 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471857007103 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 471857007104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857007105 dimer interface [polypeptide binding]; other site 471857007106 conserved gate region; other site 471857007107 ABC-ATPase subunit interface; other site 471857007108 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471857007109 Sulfatase; Region: Sulfatase; pfam00884 471857007110 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 471857007111 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471857007112 Domain of unknown function (DUF202); Region: DUF202; pfam02656 471857007113 Domain of unknown function (DUF202); Region: DUF202; cl09954 471857007114 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 471857007115 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471857007116 acyl-activating enzyme (AAE) consensus motif; other site 471857007117 putative AMP binding site [chemical binding]; other site 471857007118 putative active site [active] 471857007119 putative CoA binding site [chemical binding]; other site 471857007120 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 471857007121 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471857007122 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857007123 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471857007124 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 471857007125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857007126 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 471857007127 dimerization interface [polypeptide binding]; other site 471857007128 substrate binding pocket [chemical binding]; other site 471857007129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007131 active site 471857007132 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857007133 anti sigma factor interaction site; other site 471857007134 regulatory phosphorylation site [posttranslational modification]; other site 471857007135 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471857007136 RibD C-terminal domain; Region: RibD_C; cl17279 471857007137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857007138 G1 box; other site 471857007139 GTP/Mg2+ binding site [chemical binding]; other site 471857007140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857007141 phytoene desaturase; Region: crtI_fam; TIGR02734 471857007142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857007143 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857007144 active site lid residues [active] 471857007145 substrate binding pocket [chemical binding]; other site 471857007146 catalytic residues [active] 471857007147 substrate-Mg2+ binding site; other site 471857007148 aspartate-rich region 1; other site 471857007149 aspartate-rich region 2; other site 471857007150 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471857007151 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471857007152 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471857007153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007154 S-adenosylmethionine binding site [chemical binding]; other site 471857007155 Uncharacterized conserved protein [Function unknown]; Region: COG3349 471857007156 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 471857007157 iron-sulfur cluster [ion binding]; other site 471857007158 [2Fe-2S] cluster binding site [ion binding]; other site 471857007159 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857007160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857007161 Walker A/P-loop; other site 471857007162 ATP binding site [chemical binding]; other site 471857007163 Q-loop/lid; other site 471857007164 ABC transporter signature motif; other site 471857007165 Walker B; other site 471857007166 D-loop; other site 471857007167 H-loop/switch region; other site 471857007168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857007169 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471857007170 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 471857007171 FAD binding pocket [chemical binding]; other site 471857007172 FAD binding motif [chemical binding]; other site 471857007173 phosphate binding motif [ion binding]; other site 471857007174 beta-alpha-beta structure motif; other site 471857007175 NAD(p) ribose binding residues [chemical binding]; other site 471857007176 NAD binding pocket [chemical binding]; other site 471857007177 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471857007178 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857007179 catalytic loop [active] 471857007180 iron binding site [ion binding]; other site 471857007181 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471857007182 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 471857007183 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 471857007184 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 471857007185 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 471857007186 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 471857007187 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 471857007188 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 471857007189 substrate binding site [chemical binding]; other site 471857007190 dimer interface [polypeptide binding]; other site 471857007191 NADP binding site [chemical binding]; other site 471857007192 catalytic residues [active] 471857007193 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857007194 active site 2 [active] 471857007195 active site 1 [active] 471857007196 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 471857007197 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007198 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007199 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857007200 CoenzymeA binding site [chemical binding]; other site 471857007201 subunit interaction site [polypeptide binding]; other site 471857007202 PHB binding site; other site 471857007203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857007204 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 471857007205 acyl-activating enzyme (AAE) consensus motif; other site 471857007206 AMP binding site [chemical binding]; other site 471857007207 active site 471857007208 CoA binding site [chemical binding]; other site 471857007209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007212 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471857007213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857007214 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 471857007215 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 471857007216 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857007217 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857007218 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857007219 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 471857007220 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857007221 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471857007222 MarR family; Region: MarR_2; pfam12802 471857007223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857007225 putative substrate translocation pore; other site 471857007226 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 471857007227 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471857007228 acyl-activating enzyme (AAE) consensus motif; other site 471857007229 putative AMP binding site [chemical binding]; other site 471857007230 putative active site [active] 471857007231 putative CoA binding site [chemical binding]; other site 471857007232 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 471857007233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857007234 substrate binding site [chemical binding]; other site 471857007235 oxyanion hole (OAH) forming residues; other site 471857007236 trimer interface [polypeptide binding]; other site 471857007237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857007238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007239 sequence-specific DNA binding site [nucleotide binding]; other site 471857007240 salt bridge; other site 471857007241 hypothetical protein; Provisional; Region: PRK07588 471857007242 hypothetical protein; Provisional; Region: PRK07236 471857007243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007245 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471857007246 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471857007247 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471857007248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857007249 Walker A/P-loop; other site 471857007250 ATP binding site [chemical binding]; other site 471857007251 Q-loop/lid; other site 471857007252 ABC transporter signature motif; other site 471857007253 Walker B; other site 471857007254 D-loop; other site 471857007255 H-loop/switch region; other site 471857007256 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471857007257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857007258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857007259 active site 471857007260 phosphorylation site [posttranslational modification] 471857007261 intermolecular recognition site; other site 471857007262 dimerization interface [polypeptide binding]; other site 471857007263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857007264 DNA binding residues [nucleotide binding] 471857007265 dimerization interface [polypeptide binding]; other site 471857007266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857007267 Histidine kinase; Region: HisKA_3; pfam07730 471857007268 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471857007269 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471857007270 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 471857007271 ligand binding site [chemical binding]; other site 471857007272 flexible hinge region; other site 471857007273 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471857007274 putative switch regulator; other site 471857007275 non-specific DNA interactions [nucleotide binding]; other site 471857007276 DNA binding site [nucleotide binding] 471857007277 sequence specific DNA binding site [nucleotide binding]; other site 471857007278 putative cAMP binding site [chemical binding]; other site 471857007279 Endonuclease I; Region: Endonuclease_1; pfam04231 471857007280 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 471857007281 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471857007282 NodB motif; other site 471857007283 putative active site [active] 471857007284 putative catalytic site [active] 471857007285 putative Zn binding site [ion binding]; other site 471857007286 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471857007287 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471857007288 DXD motif; other site 471857007289 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 471857007290 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 471857007291 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 471857007292 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 471857007293 NAD binding site [chemical binding]; other site 471857007294 catalytic Zn binding site [ion binding]; other site 471857007295 structural Zn binding site [ion binding]; other site 471857007296 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857007297 Cytochrome P450; Region: p450; cl12078 471857007298 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471857007299 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 471857007300 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471857007301 Ligand Binding Site [chemical binding]; other site 471857007302 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471857007303 FAD binding site [chemical binding]; other site 471857007304 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471857007305 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 471857007306 homotetramer interface [polypeptide binding]; other site 471857007307 ligand binding site [chemical binding]; other site 471857007308 catalytic site [active] 471857007309 NAD binding site [chemical binding]; other site 471857007310 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 471857007311 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471857007312 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 471857007313 substrate binding pocket [chemical binding]; other site 471857007314 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471857007315 B12 binding site [chemical binding]; other site 471857007316 cobalt ligand [ion binding]; other site 471857007317 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471857007318 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471857007319 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857007320 substrate binding site [chemical binding]; other site 471857007321 ATP binding site [chemical binding]; other site 471857007322 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471857007323 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471857007324 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471857007325 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471857007326 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 471857007327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007328 S-adenosylmethionine binding site [chemical binding]; other site 471857007329 tocopherol O-methyltransferase; Region: PLN02244 471857007330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007331 S-adenosylmethionine binding site [chemical binding]; other site 471857007332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857007334 non-specific DNA binding site [nucleotide binding]; other site 471857007335 salt bridge; other site 471857007336 sequence-specific DNA binding site [nucleotide binding]; other site 471857007337 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857007338 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857007339 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857007340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857007341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857007342 DNA-binding site [nucleotide binding]; DNA binding site 471857007343 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 471857007344 CGNR zinc finger; Region: zf-CGNR; pfam11706 471857007345 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857007346 anti sigma factor interaction site; other site 471857007347 regulatory phosphorylation site [posttranslational modification]; other site 471857007348 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 471857007349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857007350 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857007351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857007352 DNA binding residues [nucleotide binding] 471857007353 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857007354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857007355 catalytic loop [active] 471857007356 iron binding site [ion binding]; other site 471857007357 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857007358 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857007359 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 471857007360 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857007361 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471857007362 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857007363 short chain dehydrogenase; Provisional; Region: PRK06701 471857007364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007365 NAD(P) binding site [chemical binding]; other site 471857007366 active site 471857007367 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 471857007368 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471857007369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857007370 motif II; other site 471857007371 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471857007372 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471857007373 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 471857007374 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471857007375 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857007376 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471857007377 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857007378 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 471857007379 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471857007380 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857007381 RNA binding surface [nucleotide binding]; other site 471857007382 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471857007383 active site 471857007384 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471857007385 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 471857007386 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471857007387 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471857007388 HIGH motif; other site 471857007389 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471857007390 active site 471857007391 KMSKS motif; other site 471857007392 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471857007393 tRNA binding surface [nucleotide binding]; other site 471857007394 anticodon binding site; other site 471857007395 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857007396 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 471857007397 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 471857007398 Protein of unknown function (DUF552); Region: DUF552; pfam04472 471857007399 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471857007400 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857007401 catalytic residue [active] 471857007402 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471857007403 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471857007404 cell division protein FtsZ; Validated; Region: PRK09330 471857007405 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471857007406 nucleotide binding site [chemical binding]; other site 471857007407 SulA interaction site; other site 471857007408 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471857007409 DinB superfamily; Region: DinB_2; pfam12867 471857007410 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471857007411 Cell division protein FtsQ; Region: FtsQ; pfam03799 471857007412 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471857007413 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471857007414 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857007415 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857007416 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471857007417 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471857007418 homodimer interface [polypeptide binding]; other site 471857007419 active site 471857007420 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471857007421 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471857007422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857007423 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857007424 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471857007425 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471857007426 Mg++ binding site [ion binding]; other site 471857007427 putative catalytic motif [active] 471857007428 putative substrate binding site [chemical binding]; other site 471857007429 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471857007430 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471857007431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857007432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857007433 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471857007434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857007435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857007436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857007437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857007438 Coenzyme A binding pocket [chemical binding]; other site 471857007439 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 471857007440 CoA binding domain; Region: CoA_binding_2; pfam13380 471857007441 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 471857007442 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 471857007443 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471857007444 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 471857007445 active site 471857007446 Zn binding site [ion binding]; other site 471857007447 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471857007448 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471857007449 active site residue [active] 471857007450 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471857007451 active site residue [active] 471857007452 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471857007453 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471857007454 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471857007455 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471857007456 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471857007457 NAD binding site [chemical binding]; other site 471857007458 homodimer interface [polypeptide binding]; other site 471857007459 active site 471857007460 substrate binding site [chemical binding]; other site 471857007461 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 471857007462 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 471857007463 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857007464 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 471857007465 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471857007466 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857007467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007468 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471857007469 NAD(P) binding site [chemical binding]; other site 471857007470 active site 471857007471 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 471857007472 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 471857007473 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 471857007474 active site 471857007475 dimer interface [polypeptide binding]; other site 471857007476 effector binding site; other site 471857007477 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471857007478 TSCPD domain; Region: TSCPD; pfam12637 471857007479 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471857007480 ATP cone domain; Region: ATP-cone; pfam03477 471857007481 LexA repressor; Validated; Region: PRK00215 471857007482 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 471857007483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471857007484 Catalytic site [active] 471857007485 GTPases [General function prediction only]; Region: HflX; COG2262 471857007486 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471857007487 HflX GTPase family; Region: HflX; cd01878 471857007488 G1 box; other site 471857007489 GTP/Mg2+ binding site [chemical binding]; other site 471857007490 Switch I region; other site 471857007491 G2 box; other site 471857007492 G3 box; other site 471857007493 Switch II region; other site 471857007494 G4 box; other site 471857007495 G5 box; other site 471857007496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857007497 dimerization interface [polypeptide binding]; other site 471857007498 putative DNA binding site [nucleotide binding]; other site 471857007499 putative Zn2+ binding site [ion binding]; other site 471857007500 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857007501 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471857007502 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471857007503 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471857007504 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471857007505 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471857007506 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 471857007507 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857007508 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857007509 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857007510 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471857007511 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471857007512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857007513 FeS/SAM binding site; other site 471857007514 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471857007515 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471857007516 Walker A/P-loop; other site 471857007517 ATP binding site [chemical binding]; other site 471857007518 Q-loop/lid; other site 471857007519 ABC transporter signature motif; other site 471857007520 Walker B; other site 471857007521 D-loop; other site 471857007522 H-loop/switch region; other site 471857007523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857007524 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857007525 substrate binding pocket [chemical binding]; other site 471857007526 membrane-bound complex binding site; other site 471857007527 hinge residues; other site 471857007528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857007529 dimer interface [polypeptide binding]; other site 471857007530 conserved gate region; other site 471857007531 putative PBP binding loops; other site 471857007532 ABC-ATPase subunit interface; other site 471857007533 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857007534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857007535 dimer interface [polypeptide binding]; other site 471857007536 conserved gate region; other site 471857007537 putative PBP binding loops; other site 471857007538 ABC-ATPase subunit interface; other site 471857007539 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 471857007540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857007541 catalytic loop [active] 471857007542 iron binding site [ion binding]; other site 471857007543 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 471857007544 L-aspartate oxidase; Provisional; Region: PRK06175 471857007545 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471857007546 phosphogluconate dehydratase; Validated; Region: PRK09054 471857007547 6-phosphogluconate dehydratase; Region: edd; TIGR01196 471857007548 Entner-Doudoroff aldolase; Region: eda; TIGR01182 471857007549 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471857007550 active site 471857007551 intersubunit interface [polypeptide binding]; other site 471857007552 catalytic residue [active] 471857007553 Lipase maturation factor; Region: LMF1; pfam06762 471857007554 recombination regulator RecX; Reviewed; Region: recX; PRK00117 471857007555 recombinase A; Provisional; Region: recA; PRK09354 471857007556 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471857007557 hexamer interface [polypeptide binding]; other site 471857007558 Walker A motif; other site 471857007559 ATP binding site [chemical binding]; other site 471857007560 Walker B motif; other site 471857007561 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471857007562 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 471857007563 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 471857007564 nucleotide binding site [chemical binding]; other site 471857007565 putative NEF/HSP70 interaction site [polypeptide binding]; other site 471857007566 SBD interface [polypeptide binding]; other site 471857007567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857007568 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 471857007569 ATP binding site [chemical binding]; other site 471857007570 putative Mg++ binding site [ion binding]; other site 471857007571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857007572 nucleotide binding region [chemical binding]; other site 471857007573 ATP-binding site [chemical binding]; other site 471857007574 DEAD/H associated; Region: DEAD_assoc; pfam08494 471857007575 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471857007576 active site 471857007577 catalytic residues [active] 471857007578 metal binding site [ion binding]; metal-binding site 471857007579 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471857007580 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471857007581 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 471857007582 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471857007583 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471857007584 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471857007585 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857007586 substrate binding pocket [chemical binding]; other site 471857007587 chain length determination region; other site 471857007588 substrate-Mg2+ binding site; other site 471857007589 catalytic residues [active] 471857007590 aspartate-rich region 1; other site 471857007591 active site lid residues [active] 471857007592 aspartate-rich region 2; other site 471857007593 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 471857007594 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857007595 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857007596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857007597 Walker A motif; other site 471857007598 ATP binding site [chemical binding]; other site 471857007599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857007600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857007601 DNA binding residues [nucleotide binding] 471857007602 dimerization interface [polypeptide binding]; other site 471857007603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857007604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857007605 Helix-turn-helix domain; Region: HTH_17; cl17695 471857007606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857007607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857007608 active site 471857007609 ATP binding site [chemical binding]; other site 471857007610 substrate binding site [chemical binding]; other site 471857007611 activation loop (A-loop); other site 471857007612 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857007613 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857007614 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857007615 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471857007616 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857007617 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 471857007618 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 471857007619 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 471857007620 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471857007621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471857007622 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471857007623 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471857007624 active site 471857007625 dimer interface [polypeptide binding]; other site 471857007626 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471857007627 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471857007628 active site 471857007629 FMN binding site [chemical binding]; other site 471857007630 substrate binding site [chemical binding]; other site 471857007631 3Fe-4S cluster binding site [ion binding]; other site 471857007632 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471857007633 domain interface; other site 471857007634 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471857007635 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 471857007636 putative binding site residues; other site 471857007637 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857007638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857007639 ABC-ATPase subunit interface; other site 471857007640 dimer interface [polypeptide binding]; other site 471857007641 putative PBP binding regions; other site 471857007642 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857007643 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857007644 Walker A/P-loop; other site 471857007645 ATP binding site [chemical binding]; other site 471857007646 Q-loop/lid; other site 471857007647 ABC transporter signature motif; other site 471857007648 Walker B; other site 471857007649 D-loop; other site 471857007650 H-loop/switch region; other site 471857007651 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471857007652 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471857007653 substrate binding site [chemical binding]; other site 471857007654 active site 471857007655 catalytic residues [active] 471857007656 heterodimer interface [polypeptide binding]; other site 471857007657 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471857007658 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471857007659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007660 catalytic residue [active] 471857007661 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471857007662 active site 471857007663 ribulose/triose binding site [chemical binding]; other site 471857007664 phosphate binding site [ion binding]; other site 471857007665 substrate (anthranilate) binding pocket [chemical binding]; other site 471857007666 product (indole) binding pocket [chemical binding]; other site 471857007667 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 471857007668 anthranilate synthase component I; Provisional; Region: PRK13571 471857007669 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471857007670 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471857007671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007673 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 471857007674 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471857007675 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471857007676 substrate binding site [chemical binding]; other site 471857007677 glutamase interaction surface [polypeptide binding]; other site 471857007678 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 471857007679 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471857007680 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471857007681 catalytic residues [active] 471857007682 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471857007683 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471857007684 putative active site [active] 471857007685 oxyanion strand; other site 471857007686 catalytic triad [active] 471857007687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007688 putative substrate translocation pore; other site 471857007689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857007690 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 471857007691 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471857007692 VanW like protein; Region: VanW; pfam04294 471857007693 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471857007694 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857007695 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471857007696 NAD binding site [chemical binding]; other site 471857007697 Phe binding site; other site 471857007698 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471857007699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857007700 substrate binding site [chemical binding]; other site 471857007701 oxyanion hole (OAH) forming residues; other site 471857007702 trimer interface [polypeptide binding]; other site 471857007703 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471857007704 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471857007705 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471857007706 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471857007707 Ligand binding site [chemical binding]; other site 471857007708 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471857007709 EDD domain protein, DegV family; Region: DegV; TIGR00762 471857007710 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471857007711 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857007712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007713 S-adenosylmethionine binding site [chemical binding]; other site 471857007714 Uncharacterized conserved protein [Function unknown]; Region: COG1543 471857007715 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 471857007716 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 471857007717 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471857007718 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471857007719 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471857007720 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857007721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857007722 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 471857007723 SnoaL-like domain; Region: SnoaL_2; pfam12680 471857007724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007726 malate synthase A; Region: malate_syn_A; TIGR01344 471857007727 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 471857007728 active site 471857007729 isocitrate lyase; Provisional; Region: PRK15063 471857007730 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471857007731 tetramer interface [polypeptide binding]; other site 471857007732 active site 471857007733 Mg2+/Mn2+ binding site [ion binding]; other site 471857007734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857007735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007736 non-specific DNA binding site [nucleotide binding]; other site 471857007737 salt bridge; other site 471857007738 sequence-specific DNA binding site [nucleotide binding]; other site 471857007739 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 471857007740 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471857007741 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 471857007742 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 471857007743 putative active site [active] 471857007744 Zn binding site [ion binding]; other site 471857007745 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471857007746 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471857007747 trimer interface [polypeptide binding]; other site 471857007748 active site 471857007749 substrate binding site [chemical binding]; other site 471857007750 CoA binding site [chemical binding]; other site 471857007751 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 471857007752 active site 471857007753 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471857007754 NlpC/P60 family; Region: NLPC_P60; pfam00877 471857007755 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 471857007756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857007757 Walker A/P-loop; other site 471857007758 ATP binding site [chemical binding]; other site 471857007759 Q-loop/lid; other site 471857007760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471857007761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857007762 Walker A/P-loop; other site 471857007763 ATP binding site [chemical binding]; other site 471857007764 Q-loop/lid; other site 471857007765 ABC transporter signature motif; other site 471857007766 Walker B; other site 471857007767 D-loop; other site 471857007768 H-loop/switch region; other site 471857007769 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471857007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007771 S-adenosylmethionine binding site [chemical binding]; other site 471857007772 enoyl-CoA hydratase; Provisional; Region: PRK08138 471857007773 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857007774 substrate binding site [chemical binding]; other site 471857007775 oxyanion hole (OAH) forming residues; other site 471857007776 trimer interface [polypeptide binding]; other site 471857007777 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857007778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857007779 Walker A/P-loop; other site 471857007780 ATP binding site [chemical binding]; other site 471857007781 Q-loop/lid; other site 471857007782 ABC transporter signature motif; other site 471857007783 Walker B; other site 471857007784 D-loop; other site 471857007785 H-loop/switch region; other site 471857007786 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 471857007787 putative homodimer interface [polypeptide binding]; other site 471857007788 putative active site pocket [active] 471857007789 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471857007790 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471857007791 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471857007792 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 471857007793 Domain of unknown function DUF77; Region: DUF77; pfam01910 471857007794 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857007795 MarR family; Region: MarR; pfam01047 471857007796 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 471857007797 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471857007798 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 471857007799 putative acyltransferase; Provisional; Region: PRK05790 471857007800 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857007801 dimer interface [polypeptide binding]; other site 471857007802 active site 471857007803 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471857007804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857007805 dimer interface [polypeptide binding]; other site 471857007806 substrate binding site [chemical binding]; other site 471857007807 metal binding site [ion binding]; metal-binding site 471857007808 DivIVA protein; Region: DivIVA; pfam05103 471857007809 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857007810 Ligand Binding Site [chemical binding]; other site 471857007811 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471857007812 cyclase homology domain; Region: CHD; cd07302 471857007813 nucleotidyl binding site; other site 471857007814 metal binding site [ion binding]; metal-binding site 471857007815 dimer interface [polypeptide binding]; other site 471857007816 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471857007817 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471857007818 ATP binding site [chemical binding]; other site 471857007819 Mg++ binding site [ion binding]; other site 471857007820 motif III; other site 471857007821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857007822 nucleotide binding region [chemical binding]; other site 471857007823 ATP-binding site [chemical binding]; other site 471857007824 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 471857007825 RNA binding site [nucleotide binding]; other site 471857007826 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857007827 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471857007828 NAD(P) binding site [chemical binding]; other site 471857007829 catalytic residues [active] 471857007830 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 471857007831 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471857007832 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857007833 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 471857007834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007835 S-adenosylmethionine binding site [chemical binding]; other site 471857007836 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 471857007837 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471857007838 catalytic site [active] 471857007839 putative active site [active] 471857007840 putative substrate binding site [chemical binding]; other site 471857007841 dimer interface [polypeptide binding]; other site 471857007842 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471857007843 substrate binding site [chemical binding]; other site 471857007844 dimer interface [polypeptide binding]; other site 471857007845 triosephosphate isomerase; Provisional; Region: PRK14565 471857007846 catalytic triad [active] 471857007847 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471857007848 dihydroxyacetone kinase; Provisional; Region: PRK14479 471857007849 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471857007850 DAK2 domain; Region: Dak2; pfam02734 471857007851 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 471857007852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857007853 DNA-binding site [nucleotide binding]; DNA binding site 471857007854 FCD domain; Region: FCD; pfam07729 471857007855 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857007856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471857007857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007858 NAD(P) binding site [chemical binding]; other site 471857007859 active site 471857007860 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471857007861 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007862 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007863 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471857007864 GntP family permease; Region: GntP_permease; pfam02447 471857007865 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 471857007866 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007867 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007868 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007870 active site 471857007871 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 471857007872 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 471857007873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471857007874 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857007875 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 471857007876 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 471857007877 catalytic Zn binding site [ion binding]; other site 471857007878 NAD binding site [chemical binding]; other site 471857007879 structural Zn binding site [ion binding]; other site 471857007880 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 471857007881 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471857007882 FMN binding site [chemical binding]; other site 471857007883 substrate binding site [chemical binding]; other site 471857007884 putative catalytic residue [active] 471857007885 PspC domain; Region: PspC; pfam04024 471857007886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007887 S-adenosylmethionine binding site [chemical binding]; other site 471857007888 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471857007889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857007890 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471857007891 acyl-activating enzyme (AAE) consensus motif; other site 471857007892 acyl-activating enzyme (AAE) consensus motif; other site 471857007893 putative AMP binding site [chemical binding]; other site 471857007894 putative active site [active] 471857007895 putative CoA binding site [chemical binding]; other site 471857007896 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857007897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471857007898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857007899 metal binding site [ion binding]; metal-binding site 471857007900 active site 471857007901 I-site; other site 471857007902 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 471857007903 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471857007904 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471857007905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007906 non-specific DNA binding site [nucleotide binding]; other site 471857007907 salt bridge; other site 471857007908 sequence-specific DNA binding site [nucleotide binding]; other site 471857007909 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857007910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471857007911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007913 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471857007914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857007915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007916 non-specific DNA binding site [nucleotide binding]; other site 471857007917 salt bridge; other site 471857007918 sequence-specific DNA binding site [nucleotide binding]; other site 471857007919 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 471857007920 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471857007921 active site 471857007922 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471857007923 DNA-binding site [nucleotide binding]; DNA binding site 471857007924 RNA-binding motif; other site 471857007925 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471857007926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857007927 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471857007928 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471857007929 catalytic triad [active] 471857007930 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471857007931 active site 471857007932 dimerization interface [polypeptide binding]; other site 471857007933 ribonuclease PH; Reviewed; Region: rph; PRK00173 471857007934 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471857007935 hexamer interface [polypeptide binding]; other site 471857007936 active site 471857007937 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857007938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857007939 S-adenosylmethionine binding site [chemical binding]; other site 471857007940 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471857007941 glutamate racemase; Provisional; Region: PRK00865 471857007942 Rhomboid family; Region: Rhomboid; cl11446 471857007943 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471857007944 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471857007945 dimer interface [polypeptide binding]; other site 471857007946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007947 catalytic residue [active] 471857007948 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471857007949 MoaE interaction surface [polypeptide binding]; other site 471857007950 MoeB interaction surface [polypeptide binding]; other site 471857007951 thiocarboxylated glycine; other site 471857007952 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 471857007953 MPN+ (JAMM) motif; other site 471857007954 Zinc-binding site [ion binding]; other site 471857007955 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471857007956 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 471857007957 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 471857007958 cleavage site 471857007959 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471857007960 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 471857007961 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471857007962 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471857007963 active site 471857007964 Isochorismatase family; Region: Isochorismatase; pfam00857 471857007965 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 471857007966 catalytic triad [active] 471857007967 metal binding site [ion binding]; metal-binding site 471857007968 conserved cis-peptide bond; other site 471857007969 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857007970 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857007971 substrate binding site [chemical binding]; other site 471857007972 ATP binding site [chemical binding]; other site 471857007973 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471857007974 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471857007975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471857007976 putative Mg++ binding site [ion binding]; other site 471857007977 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471857007978 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 471857007979 dimer interface [polypeptide binding]; other site 471857007980 putative active site [active] 471857007981 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 471857007982 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 471857007983 phosphoserine phosphatase SerB; Region: serB; TIGR00338 471857007984 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471857007985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857007986 motif II; other site 471857007987 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471857007988 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471857007989 D-pathway; other site 471857007990 Putative ubiquinol binding site [chemical binding]; other site 471857007991 Low-spin heme (heme b) binding site [chemical binding]; other site 471857007992 Putative water exit pathway; other site 471857007993 Binuclear center (heme o3/CuB) [ion binding]; other site 471857007994 K-pathway; other site 471857007995 Putative proton exit pathway; other site 471857007996 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471857007997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857007998 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471857007999 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471857008000 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 471857008001 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 471857008002 active site 471857008003 active pocket/dimerization site; other site 471857008004 phosphorylation site [posttranslational modification] 471857008005 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471857008006 dimerization domain swap beta strand [polypeptide binding]; other site 471857008007 regulatory protein interface [polypeptide binding]; other site 471857008008 active site 471857008009 regulatory phosphorylation site [posttranslational modification]; other site 471857008010 DAK2 domain; Region: Dak2; cl03685 471857008011 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 471857008012 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 471857008013 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 471857008014 hypothetical protein; Provisional; Region: PRK03298 471857008015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008016 dimer interface [polypeptide binding]; other site 471857008017 conserved gate region; other site 471857008018 putative PBP binding loops; other site 471857008019 ABC-ATPase subunit interface; other site 471857008020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008021 dimer interface [polypeptide binding]; other site 471857008022 conserved gate region; other site 471857008023 putative PBP binding loops; other site 471857008024 ABC-ATPase subunit interface; other site 471857008025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857008026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857008027 substrate binding pocket [chemical binding]; other site 471857008028 membrane-bound complex binding site; other site 471857008029 hinge residues; other site 471857008030 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471857008031 dimer interface [polypeptide binding]; other site 471857008032 ADP-ribose binding site [chemical binding]; other site 471857008033 active site 471857008034 nudix motif; other site 471857008035 metal binding site [ion binding]; metal-binding site 471857008036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857008037 enoyl-CoA hydratase; Validated; Region: PRK08139 471857008038 substrate binding site [chemical binding]; other site 471857008039 oxyanion hole (OAH) forming residues; other site 471857008040 trimer interface [polypeptide binding]; other site 471857008041 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471857008042 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471857008043 Walker A/P-loop; other site 471857008044 ATP binding site [chemical binding]; other site 471857008045 Q-loop/lid; other site 471857008046 ABC transporter signature motif; other site 471857008047 Walker B; other site 471857008048 D-loop; other site 471857008049 H-loop/switch region; other site 471857008050 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857008051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008052 dimer interface [polypeptide binding]; other site 471857008053 conserved gate region; other site 471857008054 putative PBP binding loops; other site 471857008055 ABC-ATPase subunit interface; other site 471857008056 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857008057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008058 dimer interface [polypeptide binding]; other site 471857008059 conserved gate region; other site 471857008060 putative PBP binding loops; other site 471857008061 ABC-ATPase subunit interface; other site 471857008062 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 471857008063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857008064 substrate binding pocket [chemical binding]; other site 471857008065 membrane-bound complex binding site; other site 471857008066 hinge residues; other site 471857008067 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 471857008068 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471857008069 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471857008070 hinge; other site 471857008071 active site 471857008072 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 471857008073 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471857008074 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 471857008075 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471857008076 gamma subunit interface [polypeptide binding]; other site 471857008077 epsilon subunit interface [polypeptide binding]; other site 471857008078 LBP interface [polypeptide binding]; other site 471857008079 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471857008080 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471857008081 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471857008082 alpha subunit interaction interface [polypeptide binding]; other site 471857008083 Walker A motif; other site 471857008084 ATP binding site [chemical binding]; other site 471857008085 Walker B motif; other site 471857008086 inhibitor binding site; inhibition site 471857008087 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471857008088 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471857008089 core domain interface [polypeptide binding]; other site 471857008090 delta subunit interface [polypeptide binding]; other site 471857008091 epsilon subunit interface [polypeptide binding]; other site 471857008092 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471857008093 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471857008094 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471857008095 beta subunit interaction interface [polypeptide binding]; other site 471857008096 Walker A motif; other site 471857008097 ATP binding site [chemical binding]; other site 471857008098 Walker B motif; other site 471857008099 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471857008100 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 471857008101 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471857008102 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 471857008103 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 471857008104 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471857008105 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471857008106 Mg++ binding site [ion binding]; other site 471857008107 putative catalytic motif [active] 471857008108 substrate binding site [chemical binding]; other site 471857008109 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471857008110 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471857008111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857008112 S-adenosylmethionine binding site [chemical binding]; other site 471857008113 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471857008114 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857008115 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857008116 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857008117 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857008118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857008119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008120 Walker A/P-loop; other site 471857008121 ATP binding site [chemical binding]; other site 471857008122 Q-loop/lid; other site 471857008123 ABC transporter signature motif; other site 471857008124 Walker B; other site 471857008125 D-loop; other site 471857008126 H-loop/switch region; other site 471857008127 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 471857008128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857008129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857008130 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471857008131 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471857008132 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471857008133 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857008134 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857008135 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471857008136 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 471857008137 FMN binding site [chemical binding]; other site 471857008138 dimer interface [polypeptide binding]; other site 471857008139 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 471857008140 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857008141 dimer interface [polypeptide binding]; other site 471857008142 active site 471857008143 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857008144 active site 471857008145 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471857008146 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857008147 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471857008148 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857008149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857008150 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471857008151 NAD(P) binding site [chemical binding]; other site 471857008152 active site 471857008153 hypothetical protein; Provisional; Region: PRK06126 471857008154 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857008155 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471857008156 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 471857008157 DNA binding site [nucleotide binding] 471857008158 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857008159 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471857008160 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471857008161 active site 471857008162 TDP-binding site; other site 471857008163 acceptor substrate-binding pocket; other site 471857008164 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471857008165 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857008166 inhibitor-cofactor binding pocket; inhibition site 471857008167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008168 catalytic residue [active] 471857008169 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471857008170 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471857008171 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471857008172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857008173 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 471857008174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857008175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857008176 S-adenosylmethionine binding site [chemical binding]; other site 471857008177 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 471857008178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857008179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857008180 DNA binding residues [nucleotide binding] 471857008181 dimerization interface [polypeptide binding]; other site 471857008182 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471857008183 PCRF domain; Region: PCRF; pfam03462 471857008184 RF-1 domain; Region: RF-1; pfam00472 471857008185 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 471857008186 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471857008187 transcription termination factor Rho; Provisional; Region: PRK12608 471857008188 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471857008189 RNA binding site [nucleotide binding]; other site 471857008190 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471857008191 multimer interface [polypeptide binding]; other site 471857008192 Walker A motif; other site 471857008193 ATP binding site [chemical binding]; other site 471857008194 Walker B motif; other site 471857008195 homoserine kinase; Provisional; Region: PRK01212 471857008196 threonine synthase; Reviewed; Region: PRK06721 471857008197 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471857008198 homodimer interface [polypeptide binding]; other site 471857008199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008200 catalytic residue [active] 471857008201 homoserine dehydrogenase; Provisional; Region: PRK06349 471857008202 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 471857008203 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471857008204 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471857008205 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471857008206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471857008207 active site 471857008208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857008209 substrate binding site [chemical binding]; other site 471857008210 catalytic residues [active] 471857008211 dimer interface [polypeptide binding]; other site 471857008212 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471857008213 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 471857008214 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471857008215 active site 471857008216 HIGH motif; other site 471857008217 KMSK motif region; other site 471857008218 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471857008219 tRNA binding surface [nucleotide binding]; other site 471857008220 anticodon binding site; other site 471857008221 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 471857008222 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471857008223 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 471857008224 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471857008225 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857008226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008227 putative substrate translocation pore; other site 471857008228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008230 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857008231 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857008232 Peptidase M15; Region: Peptidase_M15_3; cl01194 471857008233 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471857008234 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857008235 Hemerythrin-like domain; Region: Hr-like; cd12108 471857008236 Fe binding site [ion binding]; other site 471857008237 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471857008238 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857008239 catalytic residue [active] 471857008240 CoA binding domain; Region: CoA_binding; cl17356 471857008241 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471857008242 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857008243 PYR/PP interface [polypeptide binding]; other site 471857008244 dimer interface [polypeptide binding]; other site 471857008245 TPP binding site [chemical binding]; other site 471857008246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857008247 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471857008248 TPP-binding site [chemical binding]; other site 471857008249 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 471857008250 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857008251 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 471857008252 putative dimer interface [polypeptide binding]; other site 471857008253 N-terminal domain interface [polypeptide binding]; other site 471857008254 putative substrate binding pocket (H-site) [chemical binding]; other site 471857008255 putative amidase; Provisional; Region: PRK06169 471857008256 Amidase; Region: Amidase; pfam01425 471857008257 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 471857008258 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857008259 NAD binding site [chemical binding]; other site 471857008260 ligand binding site [chemical binding]; other site 471857008261 catalytic site [active] 471857008262 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471857008263 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857008264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857008265 DNA-binding site [nucleotide binding]; DNA binding site 471857008266 FCD domain; Region: FCD; pfam07729 471857008267 tartrate dehydrogenase; Region: TTC; TIGR02089 471857008268 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 471857008269 succinic semialdehyde dehydrogenase; Region: PLN02278 471857008270 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471857008271 tetramerization interface [polypeptide binding]; other site 471857008272 NAD(P) binding site [chemical binding]; other site 471857008273 catalytic residues [active] 471857008274 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 471857008275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857008276 inhibitor-cofactor binding pocket; inhibition site 471857008277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008278 catalytic residue [active] 471857008279 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 471857008280 FAD binding domain; Region: FAD_binding_4; pfam01565 471857008281 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471857008282 hypothetical protein; Validated; Region: PRK07586 471857008283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857008284 PYR/PP interface [polypeptide binding]; other site 471857008285 dimer interface [polypeptide binding]; other site 471857008286 TPP binding site [chemical binding]; other site 471857008287 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 471857008288 TPP-binding site [chemical binding]; other site 471857008289 dimer interface [polypeptide binding]; other site 471857008290 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 471857008291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857008292 substrate binding site [chemical binding]; other site 471857008293 oxyanion hole (OAH) forming residues; other site 471857008294 trimer interface [polypeptide binding]; other site 471857008295 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857008296 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857008297 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 471857008298 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857008299 dimer interface [polypeptide binding]; other site 471857008300 active site 471857008301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008305 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857008306 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008307 active site 471857008308 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857008309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008310 active site 471857008311 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 471857008312 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471857008313 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471857008314 active site 471857008315 dimerization interface [polypeptide binding]; other site 471857008316 Flavoprotein; Region: Flavoprotein; pfam02441 471857008317 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471857008318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857008319 non-specific DNA binding site [nucleotide binding]; other site 471857008320 salt bridge; other site 471857008321 sequence-specific DNA binding site [nucleotide binding]; other site 471857008322 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857008323 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 471857008324 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471857008325 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471857008326 Multicomponent K+:H+antiporter; Region: 2a6301s04; TIGR00944 471857008327 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471857008328 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 471857008329 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 471857008330 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471857008331 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 471857008332 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471857008333 Protein of unknown function, DUF488; Region: DUF488; pfam04343 471857008334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 471857008335 putative dimer interface [polypeptide binding]; other site 471857008336 ligand binding site [chemical binding]; other site 471857008337 Zn binding site [ion binding]; other site 471857008338 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857008339 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471857008340 putative NAD(P) binding site [chemical binding]; other site 471857008341 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 471857008342 Na binding site [ion binding]; other site 471857008343 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471857008344 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857008345 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857008346 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 471857008347 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471857008348 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471857008349 Coenzyme A binding pocket [chemical binding]; other site 471857008350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857008351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008352 active site 471857008353 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857008354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857008355 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471857008356 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 471857008357 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857008358 carboxyltransferase (CT) interaction site; other site 471857008359 biotinylation site [posttranslational modification]; other site 471857008360 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471857008361 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471857008362 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857008363 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857008364 active site 471857008365 oxyanion hole [active] 471857008366 catalytic triad [active] 471857008367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008369 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471857008370 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857008371 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471857008372 Walker A/P-loop; other site 471857008373 ATP binding site [chemical binding]; other site 471857008374 Q-loop/lid; other site 471857008375 ABC transporter signature motif; other site 471857008376 Walker B; other site 471857008377 D-loop; other site 471857008378 H-loop/switch region; other site 471857008379 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471857008380 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471857008381 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471857008382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008383 Walker A/P-loop; other site 471857008384 ATP binding site [chemical binding]; other site 471857008385 Q-loop/lid; other site 471857008386 ABC transporter signature motif; other site 471857008387 Walker B; other site 471857008388 D-loop; other site 471857008389 H-loop/switch region; other site 471857008390 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 471857008391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471857008392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008393 Walker A/P-loop; other site 471857008394 ATP binding site [chemical binding]; other site 471857008395 Q-loop/lid; other site 471857008396 ABC transporter signature motif; other site 471857008397 Walker B; other site 471857008398 D-loop; other site 471857008399 H-loop/switch region; other site 471857008400 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471857008401 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471857008402 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471857008403 TPP-binding site [chemical binding]; other site 471857008404 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471857008405 dimer interface [polypeptide binding]; other site 471857008406 PYR/PP interface [polypeptide binding]; other site 471857008407 TPP binding site [chemical binding]; other site 471857008408 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857008409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857008410 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471857008411 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 471857008412 calcium binding site 2 [ion binding]; other site 471857008413 active site 471857008414 catalytic triad [active] 471857008415 calcium binding site 1 [ion binding]; other site 471857008416 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 471857008417 Protein of unknown function DUF43; Region: DUF43; pfam01861 471857008418 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471857008419 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471857008420 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471857008421 putative NAD(P) binding site [chemical binding]; other site 471857008422 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 471857008423 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857008424 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 471857008425 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857008426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857008427 catalytic core [active] 471857008428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857008429 Coenzyme A binding pocket [chemical binding]; other site 471857008430 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471857008431 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471857008432 Transcription factor WhiB; Region: Whib; pfam02467 471857008433 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471857008434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471857008435 Histidine kinase; Region: HisKA_2; pfam07568 471857008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008437 ATP binding site [chemical binding]; other site 471857008438 Mg2+ binding site [ion binding]; other site 471857008439 G-X-G motif; other site 471857008440 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471857008441 putative deacylase active site [active] 471857008442 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857008443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857008444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857008445 DNA binding residues [nucleotide binding] 471857008446 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 471857008447 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 471857008448 Uncharacterized conserved protein [Function unknown]; Region: COG2135 471857008449 Predicted GTPases [General function prediction only]; Region: COG1162 471857008450 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471857008451 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471857008452 GTP/Mg2+ binding site [chemical binding]; other site 471857008453 G4 box; other site 471857008454 G1 box; other site 471857008455 Switch I region; other site 471857008456 G2 box; other site 471857008457 G3 box; other site 471857008458 Switch II region; other site 471857008459 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 471857008460 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 471857008461 Glutamate binding site [chemical binding]; other site 471857008462 NAD binding site [chemical binding]; other site 471857008463 catalytic residues [active] 471857008464 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857008465 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 471857008466 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471857008467 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471857008468 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471857008469 EspG family; Region: ESX-1_EspG; pfam14011 471857008470 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857008471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857008472 motif I; other site 471857008473 motif II; other site 471857008474 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471857008475 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471857008476 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471857008477 30S subunit binding site; other site 471857008478 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471857008479 lipoprotein LpqB; Provisional; Region: PRK13616 471857008480 Sporulation and spore germination; Region: Germane; pfam10646 471857008481 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471857008482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471857008483 dimerization interface [polypeptide binding]; other site 471857008484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857008485 dimer interface [polypeptide binding]; other site 471857008486 phosphorylation site [posttranslational modification] 471857008487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008488 ATP binding site [chemical binding]; other site 471857008489 Mg2+ binding site [ion binding]; other site 471857008490 G-X-G motif; other site 471857008491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857008492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857008493 active site 471857008494 phosphorylation site [posttranslational modification] 471857008495 intermolecular recognition site; other site 471857008496 dimerization interface [polypeptide binding]; other site 471857008497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857008498 DNA binding site [nucleotide binding] 471857008499 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471857008500 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857008501 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857008502 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 471857008503 thymidylate kinase; Validated; Region: PRK07933 471857008504 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471857008505 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471857008506 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 471857008507 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471857008508 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 471857008509 Trm112p-like protein; Region: Trm112p; cl01066 471857008510 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471857008511 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 471857008512 active site 471857008513 substrate binding site [chemical binding]; other site 471857008514 metal binding site [ion binding]; metal-binding site 471857008515 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471857008516 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 471857008517 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857008518 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471857008519 Transcription factor WhiB; Region: Whib; pfam02467 471857008520 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471857008521 active site 471857008522 putative substrate binding region [chemical binding]; other site 471857008523 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 471857008524 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857008525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857008526 Walker A/P-loop; other site 471857008527 ATP binding site [chemical binding]; other site 471857008528 Q-loop/lid; other site 471857008529 ABC transporter signature motif; other site 471857008530 Walker B; other site 471857008531 D-loop; other site 471857008532 H-loop/switch region; other site 471857008533 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857008534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857008535 Walker A/P-loop; other site 471857008536 ATP binding site [chemical binding]; other site 471857008537 Q-loop/lid; other site 471857008538 ABC transporter signature motif; other site 471857008539 Walker B; other site 471857008540 D-loop; other site 471857008541 H-loop/switch region; other site 471857008542 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857008543 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857008544 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471857008545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008546 dimer interface [polypeptide binding]; other site 471857008547 conserved gate region; other site 471857008548 putative PBP binding loops; other site 471857008549 ABC-ATPase subunit interface; other site 471857008550 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857008551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008552 dimer interface [polypeptide binding]; other site 471857008553 conserved gate region; other site 471857008554 putative PBP binding loops; other site 471857008555 ABC-ATPase subunit interface; other site 471857008556 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471857008557 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857008558 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471857008559 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471857008560 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 471857008561 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471857008562 G1 box; other site 471857008563 putative GEF interaction site [polypeptide binding]; other site 471857008564 GTP/Mg2+ binding site [chemical binding]; other site 471857008565 Switch I region; other site 471857008566 G2 box; other site 471857008567 G3 box; other site 471857008568 Switch II region; other site 471857008569 G4 box; other site 471857008570 G5 box; other site 471857008571 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471857008572 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471857008573 YCII-related domain; Region: YCII; cl00999 471857008574 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471857008575 active site 471857008576 8-oxo-dGMP binding site [chemical binding]; other site 471857008577 nudix motif; other site 471857008578 metal binding site [ion binding]; metal-binding site 471857008579 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471857008580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008581 Walker A/P-loop; other site 471857008582 ATP binding site [chemical binding]; other site 471857008583 Q-loop/lid; other site 471857008584 ABC transporter signature motif; other site 471857008585 Walker B; other site 471857008586 D-loop; other site 471857008587 H-loop/switch region; other site 471857008588 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 471857008589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471857008590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857008591 ABC-ATPase subunit interface; other site 471857008592 putative PBP binding loops; other site 471857008593 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 471857008594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471857008595 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471857008596 aromatic arch; other site 471857008597 DCoH dimer interaction site [polypeptide binding]; other site 471857008598 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471857008599 DCoH tetramer interaction site [polypeptide binding]; other site 471857008600 substrate binding site [chemical binding]; other site 471857008601 Phosphotransferase enzyme family; Region: APH; pfam01636 471857008602 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471857008603 substrate binding site [chemical binding]; other site 471857008604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857008605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857008606 active site 471857008607 phosphorylation site [posttranslational modification] 471857008608 intermolecular recognition site; other site 471857008609 dimerization interface [polypeptide binding]; other site 471857008610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857008611 DNA binding site [nucleotide binding] 471857008612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857008613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471857008614 dimerization interface [polypeptide binding]; other site 471857008615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857008616 dimer interface [polypeptide binding]; other site 471857008617 phosphorylation site [posttranslational modification] 471857008618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008619 ATP binding site [chemical binding]; other site 471857008620 Mg2+ binding site [ion binding]; other site 471857008621 G-X-G motif; other site 471857008622 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857008623 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471857008624 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471857008625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857008626 S-adenosylmethionine binding site [chemical binding]; other site 471857008627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471857008628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857008629 Coenzyme A binding pocket [chemical binding]; other site 471857008630 CAAX protease self-immunity; Region: Abi; pfam02517 471857008631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008632 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471857008633 AAA domain; Region: AAA_33; pfam13671 471857008634 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471857008635 active site 471857008636 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 471857008637 GTP-binding protein YchF; Reviewed; Region: PRK09601 471857008638 YchF GTPase; Region: YchF; cd01900 471857008639 G1 box; other site 471857008640 GTP/Mg2+ binding site [chemical binding]; other site 471857008641 Switch I region; other site 471857008642 G2 box; other site 471857008643 Switch II region; other site 471857008644 G3 box; other site 471857008645 G4 box; other site 471857008646 G5 box; other site 471857008647 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 471857008648 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 471857008649 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 471857008650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857008651 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471857008652 AlkA N-terminal domain; Region: AlkA_N; pfam06029 471857008653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857008654 minor groove reading motif; other site 471857008655 helix-hairpin-helix signature motif; other site 471857008656 substrate binding pocket [chemical binding]; other site 471857008657 active site 471857008658 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471857008659 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471857008660 DNA binding site [nucleotide binding] 471857008661 active site 471857008662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008663 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471857008664 Walker A/P-loop; other site 471857008665 ATP binding site [chemical binding]; other site 471857008666 Q-loop/lid; other site 471857008667 ABC transporter signature motif; other site 471857008668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008669 ABC transporter signature motif; other site 471857008670 Walker B; other site 471857008671 D-loop; other site 471857008672 H-loop/switch region; other site 471857008673 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471857008674 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857008675 active site 471857008676 metal binding site [ion binding]; metal-binding site 471857008677 DNA binding site [nucleotide binding] 471857008678 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471857008679 RmuC family; Region: RmuC; pfam02646 471857008680 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 471857008681 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 471857008682 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471857008683 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471857008684 generic binding surface II; other site 471857008685 generic binding surface I; other site 471857008686 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471857008687 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 471857008688 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 471857008689 putative active site [active] 471857008690 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471857008691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857008692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857008693 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471857008694 Class II fumarases; Region: Fumarase_classII; cd01362 471857008695 active site 471857008696 tetramer interface [polypeptide binding]; other site 471857008697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008699 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 471857008700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471857008701 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471857008702 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471857008703 active site 471857008704 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471857008705 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471857008706 putative active site [active] 471857008707 PhoH-like protein; Region: PhoH; pfam02562 471857008708 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471857008709 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471857008710 catalytic residue [active] 471857008711 putative FPP diphosphate binding site; other site 471857008712 putative FPP binding hydrophobic cleft; other site 471857008713 dimer interface [polypeptide binding]; other site 471857008714 putative IPP diphosphate binding site; other site 471857008715 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 471857008716 EspG family; Region: ESX-1_EspG; pfam14011 471857008717 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857008718 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857008719 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857008720 BCCT family transporter; Region: BCCT; cl00569 471857008721 choline dehydrogenase; Validated; Region: PRK02106 471857008722 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857008723 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 471857008724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857008725 tetramerization interface [polypeptide binding]; other site 471857008726 NAD(P) binding site [chemical binding]; other site 471857008727 catalytic residues [active] 471857008728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857008729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008730 Tannase and feruloyl esterase; Region: Tannase; pfam07519 471857008731 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 471857008732 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 471857008733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857008734 acyl-coenzyme A oxidase; Region: PLN02636 471857008735 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008736 active site 471857008737 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471857008738 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 471857008739 catalytic residues [active] 471857008740 SdpI/YhfL protein family; Region: SdpI; pfam13630 471857008741 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 471857008742 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 471857008743 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 471857008744 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471857008745 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471857008746 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471857008747 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857008748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 471857008749 AsnC family; Region: AsnC_trans_reg; pfam01037 471857008750 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 471857008751 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 471857008752 dimer interface [polypeptide binding]; other site 471857008753 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 471857008754 active site 471857008755 Fe binding site [ion binding]; other site 471857008756 threonine dehydratase; Provisional; Region: PRK08198 471857008757 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857008758 tetramer interface [polypeptide binding]; other site 471857008759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008760 catalytic residue [active] 471857008761 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471857008762 cystathionine gamma-synthase; Provisional; Region: PRK07811 471857008763 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857008764 homodimer interface [polypeptide binding]; other site 471857008765 substrate-cofactor binding pocket; other site 471857008766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008767 catalytic residue [active] 471857008768 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 471857008769 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471857008770 dimer interface [polypeptide binding]; other site 471857008771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008772 catalytic residue [active] 471857008773 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 471857008774 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 471857008775 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857008776 dimer interface [polypeptide binding]; other site 471857008777 active site 471857008778 Bax inhibitor 1 like; Region: BaxI_1; cl17691 471857008779 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 471857008780 active site 471857008781 putative catalytic site [active] 471857008782 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 471857008783 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 471857008784 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857008785 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857008786 intersubunit interface [polypeptide binding]; other site 471857008787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857008788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857008789 GAF domain; Region: GAF; cl17456 471857008790 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471857008791 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857008792 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471857008793 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857008794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857008795 ATP binding site [chemical binding]; other site 471857008796 Mg2+ binding site [ion binding]; other site 471857008797 G-X-G motif; other site 471857008798 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471857008799 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471857008800 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857008801 anti sigma factor interaction site; other site 471857008802 regulatory phosphorylation site [posttranslational modification]; other site 471857008803 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857008804 polyol permease family; Region: 2A0118; TIGR00897 471857008805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008806 putative substrate translocation pore; other site 471857008807 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857008808 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471857008809 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471857008810 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471857008811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471857008812 motif I; other site 471857008813 active site 471857008814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857008815 motif II; other site 471857008816 dihydroxyacetone kinase; Provisional; Region: PRK14479 471857008817 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471857008818 DAK2 domain; Region: Dak2; pfam02734 471857008819 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 471857008820 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 471857008821 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857008822 putative ligand binding site [chemical binding]; other site 471857008823 putative NAD binding site [chemical binding]; other site 471857008824 catalytic site [active] 471857008825 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 471857008826 putative N- and C-terminal domain interface [polypeptide binding]; other site 471857008827 D-xylulose kinase; Region: XylB; TIGR01312 471857008828 putative active site [active] 471857008829 MgATP binding site [chemical binding]; other site 471857008830 catalytic site [active] 471857008831 metal binding site [ion binding]; metal-binding site 471857008832 putative xylulose binding site [chemical binding]; other site 471857008833 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 471857008834 intersubunit interface [polypeptide binding]; other site 471857008835 active site 471857008836 Zn2+ binding site [ion binding]; other site 471857008837 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 471857008838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857008839 acetoin reductases; Region: 23BDH; TIGR02415 471857008840 NAD(P) binding site [chemical binding]; other site 471857008841 active site 471857008842 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857008843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008844 putative substrate translocation pore; other site 471857008845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471857008846 binding surface 471857008847 TPR motif; other site 471857008848 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857008849 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857008850 Tetratricopeptide repeat; Region: TPR_10; pfam13374 471857008851 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857008852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857008853 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 471857008854 Fe-S cluster binding site [ion binding]; other site 471857008855 DNA binding site [nucleotide binding] 471857008856 active site 471857008857 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 471857008858 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 471857008859 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471857008860 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857008861 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471857008862 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857008863 catalytic residue [active] 471857008864 Protein of unknown function (DUF501); Region: DUF501; cl00652 471857008865 Septum formation initiator; Region: DivIC; pfam04977 471857008866 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 471857008867 enolase; Provisional; Region: eno; PRK00077 471857008868 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471857008869 dimer interface [polypeptide binding]; other site 471857008870 metal binding site [ion binding]; metal-binding site 471857008871 substrate binding pocket [chemical binding]; other site 471857008872 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471857008873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857008874 TPR repeat; Region: TPR_11; pfam13414 471857008875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471857008876 TPR motif; other site 471857008877 binding surface 471857008878 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 471857008879 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471857008880 homodimer interface [polypeptide binding]; other site 471857008881 metal binding site [ion binding]; metal-binding site 471857008882 SurA N-terminal domain; Region: SurA_N_3; pfam13624 471857008883 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471857008884 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 471857008885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857008886 ATP binding site [chemical binding]; other site 471857008887 putative Mg++ binding site [ion binding]; other site 471857008888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008889 nucleotide binding region [chemical binding]; other site 471857008890 ATP-binding site [chemical binding]; other site 471857008891 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 471857008892 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857008893 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471857008894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008896 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857008897 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471857008898 Di-iron ligands [ion binding]; other site 471857008899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471857008900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857008901 metal binding site [ion binding]; metal-binding site 471857008902 active site 471857008903 I-site; other site 471857008904 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471857008905 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471857008906 Substrate binding site; other site 471857008907 Mg++ binding site; other site 471857008908 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471857008909 active site 471857008910 substrate binding site [chemical binding]; other site 471857008911 CoA binding site [chemical binding]; other site 471857008912 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471857008913 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 471857008914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857008915 active site 471857008916 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471857008917 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471857008918 5S rRNA interface [nucleotide binding]; other site 471857008919 CTC domain interface [polypeptide binding]; other site 471857008920 L16 interface [polypeptide binding]; other site 471857008921 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471857008922 putative active site [active] 471857008923 catalytic residue [active] 471857008924 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008925 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008926 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008927 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008928 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 471857008929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857008930 acyl-activating enzyme (AAE) consensus motif; other site 471857008931 AMP binding site [chemical binding]; other site 471857008932 active site 471857008933 CoA binding site [chemical binding]; other site 471857008934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857008935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857008936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471857008937 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471857008938 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471857008939 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 471857008940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857008941 Walker A/P-loop; other site 471857008942 ATP binding site [chemical binding]; other site 471857008943 Q-loop/lid; other site 471857008944 ABC transporter signature motif; other site 471857008945 Walker B; other site 471857008946 D-loop; other site 471857008947 H-loop/switch region; other site 471857008948 NIL domain; Region: NIL; pfam09383 471857008949 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471857008950 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 471857008951 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471857008952 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471857008953 G5 domain; Region: G5; pfam07501 471857008954 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 471857008955 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471857008956 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471857008957 active site 471857008958 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471857008959 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471857008960 active site 471857008961 HIGH motif; other site 471857008962 KMSKS motif; other site 471857008963 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471857008964 tRNA binding surface [nucleotide binding]; other site 471857008965 anticodon binding site; other site 471857008966 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471857008967 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 471857008968 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471857008969 Predicted methyltransferases [General function prediction only]; Region: COG0313 471857008970 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471857008971 putative SAM binding site [chemical binding]; other site 471857008972 putative homodimer interface [polypeptide binding]; other site 471857008973 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471857008974 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857008975 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857008976 active site 471857008977 ATP binding site [chemical binding]; other site 471857008978 substrate binding site [chemical binding]; other site 471857008979 activation loop (A-loop); other site 471857008980 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 471857008981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857008982 acyl-activating enzyme (AAE) consensus motif; other site 471857008983 AMP binding site [chemical binding]; other site 471857008984 active site 471857008985 CoA binding site [chemical binding]; other site 471857008986 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 471857008987 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471857008988 active site 471857008989 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471857008990 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471857008991 active site 471857008992 HIGH motif; other site 471857008993 dimer interface [polypeptide binding]; other site 471857008994 KMSKS motif; other site 471857008995 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857008996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857008997 active site 471857008998 ATP binding site [chemical binding]; other site 471857008999 substrate binding site [chemical binding]; other site 471857009000 activation loop (A-loop); other site 471857009001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857009002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857009003 active site 471857009004 ATP binding site [chemical binding]; other site 471857009005 substrate binding site [chemical binding]; other site 471857009006 activation loop (A-loop); other site 471857009007 glutamate dehydrogenase; Provisional; Region: PRK09414 471857009008 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857009009 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471857009010 NAD(P) binding site [chemical binding]; other site 471857009011 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 471857009012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471857009013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471857009014 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471857009015 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471857009016 dimer interface [polypeptide binding]; other site 471857009017 putative functional site; other site 471857009018 putative MPT binding site; other site 471857009019 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 471857009020 active site 471857009021 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 471857009022 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471857009023 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 471857009024 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 471857009025 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471857009026 MPT binding site; other site 471857009027 trimer interface [polypeptide binding]; other site 471857009028 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471857009029 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471857009030 protein binding site [polypeptide binding]; other site 471857009031 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471857009032 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471857009033 dimer interface [polypeptide binding]; other site 471857009034 active site 471857009035 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857009036 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 471857009037 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471857009038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857009039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471857009040 dimerization interface [polypeptide binding]; other site 471857009041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471857009042 dimer interface [polypeptide binding]; other site 471857009043 phosphorylation site [posttranslational modification] 471857009044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009045 ATP binding site [chemical binding]; other site 471857009046 Mg2+ binding site [ion binding]; other site 471857009047 G-X-G motif; other site 471857009048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857009049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857009050 active site 471857009051 phosphorylation site [posttranslational modification] 471857009052 intermolecular recognition site; other site 471857009053 dimerization interface [polypeptide binding]; other site 471857009054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857009055 DNA binding site [nucleotide binding] 471857009056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857009058 active site 471857009059 phosphorylation site [posttranslational modification] 471857009060 intermolecular recognition site; other site 471857009061 dimerization interface [polypeptide binding]; other site 471857009062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857009063 DNA binding residues [nucleotide binding] 471857009064 dimerization interface [polypeptide binding]; other site 471857009065 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 471857009066 potential frameshift: common BLAST hit: gi|256374724|ref|YP_003098384.1| YD repeat protein 471857009067 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857009068 RHS Repeat; Region: RHS_repeat; pfam05593 471857009069 RHS Repeat; Region: RHS_repeat; pfam05593 471857009070 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857009071 RHS Repeat; Region: RHS_repeat; pfam05593 471857009072 RHS Repeat; Region: RHS_repeat; pfam05593 471857009073 RHS Repeat; Region: RHS_repeat; pfam05593 471857009074 RHS Repeat; Region: RHS_repeat; cl11982 471857009075 RHS Repeat; Region: RHS_repeat; pfam05593 471857009076 RHS Repeat; Region: RHS_repeat; pfam05593 471857009077 RHS Repeat; Region: RHS_repeat; cl11982 471857009078 RHS Repeat; Region: RHS_repeat; cl11982 471857009079 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857009080 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471857009081 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857009082 substrate binding site [chemical binding]; other site 471857009083 oxyanion hole (OAH) forming residues; other site 471857009084 trimer interface [polypeptide binding]; other site 471857009085 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471857009086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857009087 Coenzyme A binding pocket [chemical binding]; other site 471857009088 RibD C-terminal domain; Region: RibD_C; cl17279 471857009089 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471857009090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009091 PE-PPE domain; Region: PE-PPE; pfam08237 471857009092 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 471857009093 putative active site [active] 471857009094 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 471857009095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857009097 dimerization interface [polypeptide binding]; other site 471857009098 DNA binding residues [nucleotide binding] 471857009099 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471857009100 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471857009101 active site 471857009102 TDP-binding site; other site 471857009103 acceptor substrate-binding pocket; other site 471857009104 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471857009105 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 471857009106 N- and C-terminal domain interface [polypeptide binding]; other site 471857009107 putative active site [active] 471857009108 MgATP binding site [chemical binding]; other site 471857009109 catalytic site [active] 471857009110 metal binding site [ion binding]; metal-binding site 471857009111 putative xylulose binding site [chemical binding]; other site 471857009112 putative homodimer interface [polypeptide binding]; other site 471857009113 PAS domain; Region: PAS; smart00091 471857009114 PAS fold; Region: PAS_4; pfam08448 471857009115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857009116 GAF domain; Region: GAF; pfam01590 471857009117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857009118 Histidine kinase; Region: HisKA_3; pfam07730 471857009119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009120 ATP binding site [chemical binding]; other site 471857009121 Mg2+ binding site [ion binding]; other site 471857009122 G-X-G motif; other site 471857009123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857009125 active site 471857009126 phosphorylation site [posttranslational modification] 471857009127 intermolecular recognition site; other site 471857009128 dimerization interface [polypeptide binding]; other site 471857009129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857009130 DNA binding residues [nucleotide binding] 471857009131 dimerization interface [polypeptide binding]; other site 471857009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009133 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857009134 putative substrate translocation pore; other site 471857009135 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857009136 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857009137 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 471857009138 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857009139 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 471857009140 RHS Repeat; Region: RHS_repeat; pfam05593 471857009141 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857009142 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 471857009143 protein-splicing catalytic site; other site 471857009144 thioester formation/cholesterol transfer; other site 471857009145 Pretoxin HINT domain; Region: PT-HINT; pfam07591 471857009146 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857009147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857009148 S-adenosylmethionine binding site [chemical binding]; other site 471857009149 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471857009150 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857009151 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471857009152 MgtE intracellular N domain; Region: MgtE_N; smart00924 471857009153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471857009154 Divalent cation transporter; Region: MgtE; pfam01769 471857009155 Peptidase family M48; Region: Peptidase_M48; cl12018 471857009156 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 471857009157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857009158 ATP binding site [chemical binding]; other site 471857009159 putative Mg++ binding site [ion binding]; other site 471857009160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857009161 nucleotide binding region [chemical binding]; other site 471857009162 ATP-binding site [chemical binding]; other site 471857009163 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 471857009164 HRDC domain; Region: HRDC; pfam00570 471857009165 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471857009166 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471857009167 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471857009168 FeoA domain; Region: FeoA; pfam04023 471857009169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471857009170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857009171 Coenzyme A binding pocket [chemical binding]; other site 471857009172 enoyl-CoA hydratase; Provisional; Region: PRK06688 471857009173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471857009174 substrate binding site [chemical binding]; other site 471857009175 oxyanion hole (OAH) forming residues; other site 471857009176 trimer interface [polypeptide binding]; other site 471857009177 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857009178 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 471857009179 acyl-activating enzyme (AAE) consensus motif; other site 471857009180 putative AMP binding site [chemical binding]; other site 471857009181 putative active site [active] 471857009182 putative CoA binding site [chemical binding]; other site 471857009183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857009184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857009186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857009187 active site 471857009188 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 471857009189 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 471857009190 isochorismate synthase DhbC; Validated; Region: PRK06923 471857009191 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471857009192 flavoprotein, HI0933 family; Region: TIGR00275 471857009193 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471857009194 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 471857009195 dimer interface [polypeptide binding]; other site 471857009196 acyl-activating enzyme (AAE) consensus motif; other site 471857009197 putative active site [active] 471857009198 AMP binding site [chemical binding]; other site 471857009199 putative CoA binding site [chemical binding]; other site 471857009200 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 471857009201 putative active site [active] 471857009202 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857009203 FAD binding domain; Region: FAD_binding_4; pfam01565 471857009204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857009205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009206 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857009207 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471857009208 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857009209 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471857009210 heterotetramer interface [polypeptide binding]; other site 471857009211 active site pocket [active] 471857009212 cleavage site 471857009213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857009214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857009215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471857009216 dimerization interface [polypeptide binding]; other site 471857009217 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 471857009218 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 471857009219 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471857009220 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471857009221 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 471857009222 peptide binding site [polypeptide binding]; other site 471857009223 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857009224 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471857009225 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857009226 PYR/PP interface [polypeptide binding]; other site 471857009227 dimer interface [polypeptide binding]; other site 471857009228 TPP binding site [chemical binding]; other site 471857009229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857009230 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471857009231 TPP-binding site [chemical binding]; other site 471857009232 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 471857009233 active site 471857009234 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471857009235 Ligand Binding Site [chemical binding]; other site 471857009236 Molecular Tunnel; other site 471857009237 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471857009238 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 471857009239 active site 471857009240 metal binding site [ion binding]; metal-binding site 471857009241 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 471857009242 substrate binding pocket [chemical binding]; other site 471857009243 active site 471857009244 iron coordination sites [ion binding]; other site 471857009245 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 471857009246 peptide binding site [polypeptide binding]; other site 471857009247 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857009248 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471857009249 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471857009250 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 471857009251 EamA-like transporter family; Region: EamA; pfam00892 471857009252 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 471857009253 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 471857009254 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857009255 Cytochrome P450; Region: p450; cl12078 471857009256 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471857009257 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 471857009258 NADP binding site [chemical binding]; other site 471857009259 homotetramer interface [polypeptide binding]; other site 471857009260 homodimer interface [polypeptide binding]; other site 471857009261 active site 471857009262 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471857009263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471857009264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857009265 Coenzyme A binding pocket [chemical binding]; other site 471857009266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857009267 DNA-binding site [nucleotide binding]; DNA binding site 471857009268 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857009269 UTRA domain; Region: UTRA; pfam07702 471857009270 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471857009271 Cytochrome P450; Region: p450; cl12078 471857009272 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471857009273 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857009274 G1 box; other site 471857009275 GTP/Mg2+ binding site [chemical binding]; other site 471857009276 G2 box; other site 471857009277 Switch I region; other site 471857009278 G3 box; other site 471857009279 Switch II region; other site 471857009280 G4 box; other site 471857009281 G5 box; other site 471857009282 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857009283 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009285 ATP binding site [chemical binding]; other site 471857009286 Mg2+ binding site [ion binding]; other site 471857009287 G-X-G motif; other site 471857009288 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 471857009289 Active_site [active] 471857009290 thiamine pyrophosphate protein; Provisional; Region: PRK08273 471857009291 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471857009292 PYR/PP interface [polypeptide binding]; other site 471857009293 dimer interface [polypeptide binding]; other site 471857009294 tetramer interface [polypeptide binding]; other site 471857009295 TPP binding site [chemical binding]; other site 471857009296 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857009297 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 471857009298 TPP-binding site [chemical binding]; other site 471857009299 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471857009300 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 471857009301 dimer interface [polypeptide binding]; other site 471857009302 active site 471857009303 citrylCoA binding site [chemical binding]; other site 471857009304 NADH binding [chemical binding]; other site 471857009305 cationic pore residues; other site 471857009306 oxalacetate/citrate binding site [chemical binding]; other site 471857009307 coenzyme A binding site [chemical binding]; other site 471857009308 catalytic triad [active] 471857009309 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857009310 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471857009311 putative substrate binding site [chemical binding]; other site 471857009312 putative ATP binding site [chemical binding]; other site 471857009313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857009314 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 471857009315 active site 471857009316 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857009317 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471857009318 active site 471857009319 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 471857009320 active site 471857009321 catalytic residues [active] 471857009322 SchA/CurD like domain; Region: SchA_CurD; pfam04486 471857009323 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 471857009324 Cupin domain; Region: Cupin_2; pfam07883 471857009325 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857009326 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857009327 dimer interface [polypeptide binding]; other site 471857009328 active site 471857009329 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 471857009330 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857009331 active site 471857009332 acyl carrier protein; Provisional; Region: acpP; PRK00982 471857009333 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 471857009334 putative hydrophobic ligand binding site [chemical binding]; other site 471857009335 active site 471857009336 catalytic residues_2 [active] 471857009337 catalytic residues_1 [active] 471857009338 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 471857009339 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 471857009340 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 471857009341 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471857009342 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 471857009343 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471857009344 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471857009345 carboxyltransferase (CT) interaction site; other site 471857009346 biotinylation site [posttranslational modification]; other site 471857009347 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471857009348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857009349 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471857009350 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 471857009351 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 471857009352 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857009353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009354 NB-ARC domain; Region: NB-ARC; pfam00931 471857009355 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471857009356 Walker A motif; other site 471857009357 Walker A motif; other site 471857009358 ATP binding site [chemical binding]; other site 471857009359 ATP binding site [chemical binding]; other site 471857009360 Walker B motif; other site 471857009361 enterobactin exporter EntS; Provisional; Region: PRK10489 471857009362 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471857009363 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471857009364 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 471857009365 citrate synthase 2; Provisional; Region: PRK12350 471857009366 Citrate synthase; Region: Citrate_synt; pfam00285 471857009367 oxalacetate binding site [chemical binding]; other site 471857009368 citrylCoA binding site [chemical binding]; other site 471857009369 coenzyme A binding site [chemical binding]; other site 471857009370 catalytic triad [active] 471857009371 short chain dehydrogenase; Validated; Region: PRK05855 471857009372 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857009373 classical (c) SDRs; Region: SDR_c; cd05233 471857009374 NAD(P) binding site [chemical binding]; other site 471857009375 active site 471857009376 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 471857009377 L-lactate permease; Region: Lactate_perm; cl00701 471857009378 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857009379 Beta-lactamase; Region: Beta-lactamase; pfam00144 471857009380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857009381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857009382 catalytic residue [active] 471857009383 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471857009384 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 471857009385 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471857009386 NAD binding site [chemical binding]; other site 471857009387 substrate binding site [chemical binding]; other site 471857009388 active site 471857009389 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471857009390 Ligand binding site; other site 471857009391 Putative Catalytic site; other site 471857009392 DXD motif; other site 471857009393 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857009394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009395 NAD(P) binding site [chemical binding]; other site 471857009396 active site 471857009397 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 471857009398 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471857009399 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471857009400 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471857009401 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471857009402 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471857009403 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471857009404 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009406 putative substrate translocation pore; other site 471857009407 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471857009408 MarR family; Region: MarR; pfam01047 471857009409 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471857009410 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 471857009411 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471857009412 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 471857009413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857009415 putative substrate translocation pore; other site 471857009416 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 471857009417 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471857009418 DNA-binding site [nucleotide binding]; DNA binding site 471857009419 RNA-binding motif; other site 471857009420 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471857009421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857009422 motif II; other site 471857009423 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 471857009424 active site 471857009425 diiron metal binding site [ion binding]; other site 471857009426 AMP-binding domain protein; Validated; Region: PRK08315 471857009427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471857009428 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 471857009429 acyl-activating enzyme (AAE) consensus motif; other site 471857009430 putative AMP binding site [chemical binding]; other site 471857009431 putative active site [active] 471857009432 putative CoA binding site [chemical binding]; other site 471857009433 hypothetical protein; Provisional; Region: PRK11770 471857009434 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471857009435 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471857009436 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857009437 active site 471857009438 metal binding site [ion binding]; metal-binding site 471857009439 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471857009440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857009441 active site 471857009442 motif I; other site 471857009443 motif II; other site 471857009444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857009445 active site 471857009446 motif I; other site 471857009447 motif II; other site 471857009448 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 471857009449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857009450 Walker A/P-loop; other site 471857009451 ATP binding site [chemical binding]; other site 471857009452 Q-loop/lid; other site 471857009453 ABC transporter signature motif; other site 471857009454 Walker B; other site 471857009455 D-loop; other site 471857009456 H-loop/switch region; other site 471857009457 TOBE domain; Region: TOBE; pfam03459 471857009458 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471857009459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857009460 putative PBP binding loops; other site 471857009461 ABC-ATPase subunit interface; other site 471857009462 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471857009463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471857009464 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857009465 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471857009466 DNA binding residues [nucleotide binding] 471857009467 TOBE domain; Region: TOBE; cl01440 471857009468 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471857009469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471857009470 FeS/SAM binding site; other site 471857009471 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471857009472 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471857009473 MoaE interaction surface [polypeptide binding]; other site 471857009474 MoeB interaction surface [polypeptide binding]; other site 471857009475 thiocarboxylated glycine; other site 471857009476 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 471857009477 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471857009478 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471857009479 MPT binding site; other site 471857009480 trimer interface [polypeptide binding]; other site 471857009481 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471857009482 MoaE homodimer interface [polypeptide binding]; other site 471857009483 MoaD interaction [polypeptide binding]; other site 471857009484 active site residues [active] 471857009485 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 471857009486 trimer interface [polypeptide binding]; other site 471857009487 dimer interface [polypeptide binding]; other site 471857009488 putative active site [active] 471857009489 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471857009490 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471857009491 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471857009492 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471857009493 putative NAD(P) binding site [chemical binding]; other site 471857009494 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471857009495 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857009496 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857009497 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471857009498 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857009499 G1 box; other site 471857009500 GTP/Mg2+ binding site [chemical binding]; other site 471857009501 G2 box; other site 471857009502 Switch I region; other site 471857009503 G3 box; other site 471857009504 Switch II region; other site 471857009505 G4 box; other site 471857009506 G5 box; other site 471857009507 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857009508 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857009509 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857009510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857009511 HAMP domain; Region: HAMP; pfam00672 471857009512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009513 ATP binding site [chemical binding]; other site 471857009514 Mg2+ binding site [ion binding]; other site 471857009515 G-X-G motif; other site 471857009516 NMT1/THI5 like; Region: NMT1; pfam09084 471857009517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857009518 substrate binding pocket [chemical binding]; other site 471857009519 membrane-bound complex binding site; other site 471857009520 hinge residues; other site 471857009521 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471857009522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857009523 dimer interface [polypeptide binding]; other site 471857009524 conserved gate region; other site 471857009525 putative PBP binding loops; other site 471857009526 ABC-ATPase subunit interface; other site 471857009527 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471857009528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857009529 dimer interface [polypeptide binding]; other site 471857009530 conserved gate region; other site 471857009531 putative PBP binding loops; other site 471857009532 ABC-ATPase subunit interface; other site 471857009533 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471857009534 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471857009535 Walker A/P-loop; other site 471857009536 ATP binding site [chemical binding]; other site 471857009537 Q-loop/lid; other site 471857009538 ABC transporter signature motif; other site 471857009539 Walker B; other site 471857009540 D-loop; other site 471857009541 H-loop/switch region; other site 471857009542 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857009543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857009544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009545 ATP binding site [chemical binding]; other site 471857009546 Mg2+ binding site [ion binding]; other site 471857009547 G-X-G motif; other site 471857009548 NMT1-like family; Region: NMT1_2; pfam13379 471857009549 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471857009550 substrate binding pocket [chemical binding]; other site 471857009551 membrane-bound complex binding site; other site 471857009552 hinge residues; other site 471857009553 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471857009554 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471857009555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857009556 ATP binding site [chemical binding]; other site 471857009557 putative Mg++ binding site [ion binding]; other site 471857009558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857009559 nucleotide binding region [chemical binding]; other site 471857009560 ATP-binding site [chemical binding]; other site 471857009561 Protein of unknown function DUF72; Region: DUF72; pfam01904 471857009562 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 471857009563 intracellular protease, PfpI family; Region: PfpI; TIGR01382 471857009564 proposed catalytic triad [active] 471857009565 conserved cys residue [active] 471857009566 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471857009567 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471857009568 ring oligomerisation interface [polypeptide binding]; other site 471857009569 ATP/Mg binding site [chemical binding]; other site 471857009570 stacking interactions; other site 471857009571 hinge regions; other site 471857009572 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 471857009573 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 471857009574 putative ligand binding residues [chemical binding]; other site 471857009575 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857009576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857009577 ABC-ATPase subunit interface; other site 471857009578 dimer interface [polypeptide binding]; other site 471857009579 putative PBP binding regions; other site 471857009580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471857009581 ABC-ATPase subunit interface; other site 471857009582 dimer interface [polypeptide binding]; other site 471857009583 putative PBP binding regions; other site 471857009584 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 471857009585 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857009586 Walker A/P-loop; other site 471857009587 ATP binding site [chemical binding]; other site 471857009588 Q-loop/lid; other site 471857009589 ABC transporter signature motif; other site 471857009590 Walker B; other site 471857009591 D-loop; other site 471857009592 H-loop/switch region; other site 471857009593 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857009594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857009595 active site 471857009596 ATP binding site [chemical binding]; other site 471857009597 substrate binding site [chemical binding]; other site 471857009598 activation loop (A-loop); other site 471857009599 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471857009600 DNA-binding site [nucleotide binding]; DNA binding site 471857009601 RNA-binding motif; other site 471857009602 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 471857009603 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 471857009604 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471857009605 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471857009606 dimer interface [polypeptide binding]; other site 471857009607 putative functional site; other site 471857009608 putative MPT binding site; other site 471857009609 Predicted membrane protein [Function unknown]; Region: COG2261 471857009610 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 471857009611 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471857009612 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 471857009613 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 471857009614 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 471857009615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471857009616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009617 Walker A motif; other site 471857009618 ATP binding site [chemical binding]; other site 471857009619 Walker B motif; other site 471857009620 arginine finger; other site 471857009621 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471857009622 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471857009623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471857009624 active site 471857009625 catalytic residues [active] 471857009626 metal binding site [ion binding]; metal-binding site 471857009627 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 471857009628 ThiC-associated domain; Region: ThiC-associated; pfam13667 471857009629 ThiC family; Region: ThiC; pfam01964 471857009630 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471857009631 dimer interface [polypeptide binding]; other site 471857009632 substrate binding site [chemical binding]; other site 471857009633 ATP binding site [chemical binding]; other site 471857009634 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471857009635 substrate binding site [chemical binding]; other site 471857009636 dimer interface [polypeptide binding]; other site 471857009637 ATP binding site [chemical binding]; other site 471857009638 AAA domain; Region: AAA_14; pfam13173 471857009639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471857009640 TPR motif; other site 471857009641 binding surface 471857009642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857009643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471857009644 binding surface 471857009645 TPR motif; other site 471857009646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857009647 Nodulation protein A (NodA); Region: NodA; cl17421 471857009648 MarR family; Region: MarR; pfam01047 471857009649 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471857009650 ThiS interaction site; other site 471857009651 putative active site [active] 471857009652 tetramer interface [polypeptide binding]; other site 471857009653 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471857009654 thiS-thiF/thiG interaction site; other site 471857009655 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 471857009656 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471857009657 thiamine phosphate binding site [chemical binding]; other site 471857009658 active site 471857009659 pyrophosphate binding site [ion binding]; other site 471857009660 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857009661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857009662 DNA-binding site [nucleotide binding]; DNA binding site 471857009663 UTRA domain; Region: UTRA; pfam07702 471857009664 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471857009665 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857009666 dimer interface [polypeptide binding]; other site 471857009667 active site 471857009668 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857009669 dimer interface [polypeptide binding]; other site 471857009670 active site 471857009671 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 471857009672 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471857009673 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471857009674 active site 471857009675 catalytic triad [active] 471857009676 oxyanion hole [active] 471857009677 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471857009678 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471857009679 ligand binding site [chemical binding]; other site 471857009680 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 471857009681 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 471857009682 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 471857009683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471857009684 inhibitor-cofactor binding pocket; inhibition site 471857009685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857009686 catalytic residue [active] 471857009687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471857009688 Coenzyme A binding pocket [chemical binding]; other site 471857009689 DinB superfamily; Region: DinB_2; pfam12867 471857009690 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471857009691 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857009692 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471857009693 nucleotide binding site [chemical binding]; other site 471857009694 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 471857009695 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 471857009696 Predicted esterase [General function prediction only]; Region: COG0400 471857009697 putative hydrolase; Provisional; Region: PRK11460 471857009698 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 471857009699 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857009700 Zn binding site [ion binding]; other site 471857009701 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 471857009702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471857009703 Zn binding site [ion binding]; other site 471857009704 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857009705 MarR family; Region: MarR_2; pfam12802 471857009706 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 471857009707 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 471857009708 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471857009709 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 471857009710 active site 471857009711 DNA binding site [nucleotide binding] 471857009712 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471857009713 DNA binding site [nucleotide binding] 471857009714 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 471857009715 nucleotide binding site [chemical binding]; other site 471857009716 GAF domain; Region: GAF_2; pfam13185 471857009717 GAF domain; Region: GAF; pfam01590 471857009718 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471857009719 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471857009720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009721 ATP binding site [chemical binding]; other site 471857009722 Mg2+ binding site [ion binding]; other site 471857009723 G-X-G motif; other site 471857009724 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857009725 anti sigma factor interaction site; other site 471857009726 regulatory phosphorylation site [posttranslational modification]; other site 471857009727 hypothetical protein; Provisional; Region: PRK02947 471857009728 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857009729 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471857009730 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471857009731 active site 471857009732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857009733 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857009734 active site residue [active] 471857009735 amphi-Trp domain; Region: amphi-Trp; TIGR04354 471857009736 B12 binding domain; Region: B12-binding_2; pfam02607 471857009737 B12 binding domain; Region: B12-binding; pfam02310 471857009738 B12 binding site [chemical binding]; other site 471857009739 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857009740 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471857009741 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471857009742 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471857009743 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 471857009744 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 471857009745 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 471857009746 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 471857009747 active site 471857009748 homotetramer interface [polypeptide binding]; other site 471857009749 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 471857009750 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 471857009751 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471857009752 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471857009753 DNA repair protein RadA; Provisional; Region: PRK11823 471857009754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471857009755 Walker A motif; other site 471857009756 ATP binding site [chemical binding]; other site 471857009757 Walker B motif; other site 471857009758 Protein of unknown function (DUF461); Region: DUF461; cl01071 471857009759 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 471857009760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857009761 active site 471857009762 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471857009763 homotrimer interaction site [polypeptide binding]; other site 471857009764 zinc binding site [ion binding]; other site 471857009765 CDP-binding sites; other site 471857009766 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471857009767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857009768 motif II; other site 471857009769 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471857009770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857009771 active site 471857009772 HIGH motif; other site 471857009773 nucleotide binding site [chemical binding]; other site 471857009774 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471857009775 KMSKS motif; other site 471857009776 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471857009777 tRNA binding surface [nucleotide binding]; other site 471857009778 anticodon binding site; other site 471857009779 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471857009780 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471857009781 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471857009782 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471857009783 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857009784 Family description; Region: UvrD_C_2; pfam13538 471857009785 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 471857009786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857009787 ATP binding site [chemical binding]; other site 471857009788 putative Mg++ binding site [ion binding]; other site 471857009789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857009790 ATP-binding site [chemical binding]; other site 471857009791 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471857009792 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 471857009793 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 471857009794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857009795 ATP binding site [chemical binding]; other site 471857009796 putative Mg++ binding site [ion binding]; other site 471857009797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857009798 nucleotide binding region [chemical binding]; other site 471857009799 ATP-binding site [chemical binding]; other site 471857009800 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857009801 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857009802 active site 471857009803 ATP binding site [chemical binding]; other site 471857009804 substrate binding site [chemical binding]; other site 471857009805 activation loop (A-loop); other site 471857009806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471857009807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471857009808 binding surface 471857009809 TPR motif; other site 471857009810 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 471857009811 classical (c) SDRs; Region: SDR_c; cd05233 471857009812 NAD(P) binding site [chemical binding]; other site 471857009813 active site 471857009814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 471857009815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 471857009816 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471857009817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471857009818 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857009819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857009820 Walker A/P-loop; other site 471857009821 ATP binding site [chemical binding]; other site 471857009822 Q-loop/lid; other site 471857009823 ABC transporter signature motif; other site 471857009824 Walker B; other site 471857009825 D-loop; other site 471857009826 H-loop/switch region; other site 471857009827 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471857009828 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471857009829 intersubunit interface [polypeptide binding]; other site 471857009830 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857009831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857009832 DNA binding site [nucleotide binding] 471857009833 domain linker motif; other site 471857009834 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 471857009835 putative dimerization interface [polypeptide binding]; other site 471857009836 putative ligand binding site [chemical binding]; other site 471857009837 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 471857009838 active site clefts [active] 471857009839 zinc binding site [ion binding]; other site 471857009840 dimer interface [polypeptide binding]; other site 471857009841 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 471857009842 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857009843 minor groove reading motif; other site 471857009844 helix-hairpin-helix signature motif; other site 471857009845 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 471857009846 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471857009847 amidase catalytic site [active] 471857009848 Zn binding residues [ion binding]; other site 471857009849 substrate binding site [chemical binding]; other site 471857009850 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857009851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857009852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009853 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857009854 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471857009855 catalytic site [active] 471857009856 TAP-like protein; Region: Abhydrolase_4; pfam08386 471857009857 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471857009858 Peptidase family M1; Region: Peptidase_M1; pfam01433 471857009859 Zn binding site [ion binding]; other site 471857009860 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 471857009861 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 471857009862 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471857009863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857009864 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857009865 Walker A/P-loop; other site 471857009866 ATP binding site [chemical binding]; other site 471857009867 Q-loop/lid; other site 471857009868 ABC transporter signature motif; other site 471857009869 Walker B; other site 471857009870 D-loop; other site 471857009871 H-loop/switch region; other site 471857009872 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471857009873 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471857009874 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857009875 AAA ATPase domain; Region: AAA_16; pfam13191 471857009876 Predicted ATPase [General function prediction only]; Region: COG3903 471857009877 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471857009878 Clp amino terminal domain; Region: Clp_N; pfam02861 471857009879 Clp amino terminal domain; Region: Clp_N; pfam02861 471857009880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009881 Walker A motif; other site 471857009882 ATP binding site [chemical binding]; other site 471857009883 Walker B motif; other site 471857009884 arginine finger; other site 471857009885 UvrB/uvrC motif; Region: UVR; pfam02151 471857009886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009887 Walker A motif; other site 471857009888 ATP binding site [chemical binding]; other site 471857009889 Walker B motif; other site 471857009890 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471857009891 EspG family; Region: ESX-1_EspG; pfam14011 471857009892 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857009893 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857009894 Lsr2; Region: Lsr2; pfam11774 471857009895 pantothenate kinase; Reviewed; Region: PRK13318 471857009896 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471857009897 tetramerization interface [polypeptide binding]; other site 471857009898 active site 471857009899 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471857009900 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471857009901 active site 471857009902 ATP-binding site [chemical binding]; other site 471857009903 pantoate-binding site; other site 471857009904 HXXH motif; other site 471857009905 Rossmann-like domain; Region: Rossmann-like; pfam10727 471857009906 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471857009907 Protease prsW family; Region: PrsW-protease; pfam13367 471857009908 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 471857009909 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857009910 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857009911 DNA binding residues [nucleotide binding] 471857009912 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471857009913 catalytic center binding site [active] 471857009914 ATP binding site [chemical binding]; other site 471857009915 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471857009916 homooctamer interface [polypeptide binding]; other site 471857009917 active site 471857009918 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471857009919 dihydropteroate synthase; Region: DHPS; TIGR01496 471857009920 substrate binding pocket [chemical binding]; other site 471857009921 dimer interface [polypeptide binding]; other site 471857009922 inhibitor binding site; inhibition site 471857009923 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471857009924 homodecamer interface [polypeptide binding]; other site 471857009925 active site 471857009926 putative catalytic site residues [active] 471857009927 zinc binding site [ion binding]; other site 471857009928 GTP-CH-I/GFRP interaction surface; other site 471857009929 FtsH Extracellular; Region: FtsH_ext; pfam06480 471857009930 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471857009931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009932 Walker A motif; other site 471857009933 ATP binding site [chemical binding]; other site 471857009934 Walker B motif; other site 471857009935 arginine finger; other site 471857009936 Peptidase family M41; Region: Peptidase_M41; pfam01434 471857009937 EspG family; Region: ESX-1_EspG; pfam14011 471857009938 EspG family; Region: ESX-1_EspG; pfam14011 471857009939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857009940 active site 471857009941 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471857009942 Ligand Binding Site [chemical binding]; other site 471857009943 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471857009944 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 471857009945 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 471857009946 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471857009947 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 471857009948 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471857009949 inorganic pyrophosphatase; Provisional; Region: PRK02230 471857009950 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471857009951 dimer interface [polypeptide binding]; other site 471857009952 substrate binding site [chemical binding]; other site 471857009953 metal binding sites [ion binding]; metal-binding site 471857009954 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471857009955 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471857009956 trimer interface [polypeptide binding]; other site 471857009957 putative metal binding site [ion binding]; other site 471857009958 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471857009959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857009960 Walker A motif; other site 471857009961 ATP binding site [chemical binding]; other site 471857009962 Walker B motif; other site 471857009963 arginine finger; other site 471857009964 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471857009965 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471857009966 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471857009967 active site 471857009968 interdomain interaction site; other site 471857009969 putative metal-binding site [ion binding]; other site 471857009970 nucleotide binding site [chemical binding]; other site 471857009971 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 471857009972 domain I; other site 471857009973 phosphate binding site [ion binding]; other site 471857009974 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471857009975 domain II; other site 471857009976 domain III; other site 471857009977 nucleotide binding site [chemical binding]; other site 471857009978 DNA binding groove [nucleotide binding] 471857009979 catalytic site [active] 471857009980 domain IV; other site 471857009981 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471857009982 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471857009983 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471857009984 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471857009985 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 471857009986 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471857009987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857009988 ATP binding site [chemical binding]; other site 471857009989 putative Mg++ binding site [ion binding]; other site 471857009990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857009991 nucleotide binding region [chemical binding]; other site 471857009992 ATP-binding site [chemical binding]; other site 471857009993 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471857009994 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 471857009995 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 471857009996 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 471857009997 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 471857009998 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 471857009999 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471857010000 Type II/IV secretion system protein; Region: T2SE; pfam00437 471857010001 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471857010002 Walker A motif; other site 471857010003 hexamer interface [polypeptide binding]; other site 471857010004 ATP binding site [chemical binding]; other site 471857010005 Walker B motif; other site 471857010006 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471857010007 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471857010008 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 471857010009 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471857010010 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471857010011 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471857010012 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 471857010013 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857010014 Beta-lactamase; Region: Beta-lactamase; pfam00144 471857010015 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 471857010016 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471857010017 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471857010018 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471857010019 putative active site [active] 471857010020 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471857010021 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471857010022 putative active site [active] 471857010023 acetyl-CoA synthetase; Provisional; Region: PRK00174 471857010024 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 471857010025 active site 471857010026 CoA binding site [chemical binding]; other site 471857010027 acyl-activating enzyme (AAE) consensus motif; other site 471857010028 AMP binding site [chemical binding]; other site 471857010029 acetate binding site [chemical binding]; other site 471857010030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857010031 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 471857010032 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 471857010033 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857010034 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471857010035 Colicin V production protein; Region: Colicin_V; pfam02674 471857010036 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471857010037 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471857010038 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471857010039 putative active site [active] 471857010040 putative CoA binding site [chemical binding]; other site 471857010041 nudix motif; other site 471857010042 metal binding site [ion binding]; metal-binding site 471857010043 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471857010044 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471857010045 catalytic residues [active] 471857010046 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471857010047 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857010048 minor groove reading motif; other site 471857010049 helix-hairpin-helix signature motif; other site 471857010050 substrate binding pocket [chemical binding]; other site 471857010051 active site 471857010052 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471857010053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471857010054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471857010055 ligand binding site [chemical binding]; other site 471857010056 flexible hinge region; other site 471857010057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471857010058 putative switch regulator; other site 471857010059 non-specific DNA interactions [nucleotide binding]; other site 471857010060 DNA binding site [nucleotide binding] 471857010061 sequence specific DNA binding site [nucleotide binding]; other site 471857010062 putative cAMP binding site [chemical binding]; other site 471857010063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857010064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857010065 putative substrate translocation pore; other site 471857010066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471857010067 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471857010068 homotrimer interaction site [polypeptide binding]; other site 471857010069 putative active site [active] 471857010070 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 471857010071 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 471857010072 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857010073 DTAP/Switch II; other site 471857010074 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 471857010075 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857010076 DTAP/Switch II; other site 471857010077 Switch I; other site 471857010078 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471857010079 Transcription factor WhiB; Region: Whib; pfam02467 471857010080 Transglycosylase; Region: Transgly; pfam00912 471857010081 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471857010082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471857010083 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471857010084 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857010085 putative active site [active] 471857010086 putative metal binding site [ion binding]; other site 471857010087 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471857010088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857010089 S-adenosylmethionine binding site [chemical binding]; other site 471857010090 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857010091 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857010092 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 471857010093 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471857010094 dimerization interface [polypeptide binding]; other site 471857010095 DPS ferroxidase diiron center [ion binding]; other site 471857010096 ion pore; other site 471857010097 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471857010098 Predicted flavoprotein [General function prediction only]; Region: COG0431 471857010099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471857010100 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471857010101 substrate binding pocket [chemical binding]; other site 471857010102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471857010103 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857010104 metal binding site 2 [ion binding]; metal-binding site 471857010105 putative DNA binding helix; other site 471857010106 metal binding site 1 [ion binding]; metal-binding site 471857010107 dimer interface [polypeptide binding]; other site 471857010108 structural Zn2+ binding site [ion binding]; other site 471857010109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857010110 putative substrate translocation pore; other site 471857010111 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471857010112 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471857010113 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471857010114 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471857010115 aspartate kinase; Reviewed; Region: PRK06635 471857010116 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471857010117 putative nucleotide binding site [chemical binding]; other site 471857010118 putative catalytic residues [active] 471857010119 putative Mg ion binding site [ion binding]; other site 471857010120 putative aspartate binding site [chemical binding]; other site 471857010121 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471857010122 putative allosteric regulatory site; other site 471857010123 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 471857010124 putative allosteric regulatory residue; other site 471857010125 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 471857010126 putative FMN binding site [chemical binding]; other site 471857010127 2-isopropylmalate synthase; Validated; Region: PRK03739 471857010128 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471857010129 active site 471857010130 catalytic residues [active] 471857010131 metal binding site [ion binding]; metal-binding site 471857010132 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471857010133 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471857010134 Predicted transcriptional regulator [Transcription]; Region: COG2378 471857010135 HTH domain; Region: HTH_11; pfam08279 471857010136 WYL domain; Region: WYL; pfam13280 471857010137 short chain dehydrogenase; Provisional; Region: PRK08303 471857010138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857010139 NAD(P) binding site [chemical binding]; other site 471857010140 active site 471857010141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857010142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471857010143 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857010144 putative dimerization interface [polypeptide binding]; other site 471857010145 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471857010146 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 471857010147 EamA-like transporter family; Region: EamA; pfam00892 471857010148 EamA-like transporter family; Region: EamA; pfam00892 471857010149 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 471857010150 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857010151 Walker A/P-loop; other site 471857010152 ATP binding site [chemical binding]; other site 471857010153 Q-loop/lid; other site 471857010154 ABC transporter signature motif; other site 471857010155 Walker B; other site 471857010156 D-loop; other site 471857010157 H-loop/switch region; other site 471857010158 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471857010159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471857010160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471857010161 Walker A/P-loop; other site 471857010162 ATP binding site [chemical binding]; other site 471857010163 Q-loop/lid; other site 471857010164 ABC transporter signature motif; other site 471857010165 Walker B; other site 471857010166 D-loop; other site 471857010167 H-loop/switch region; other site 471857010168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857010169 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471857010170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857010171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857010172 dimer interface [polypeptide binding]; other site 471857010173 conserved gate region; other site 471857010174 ABC-ATPase subunit interface; other site 471857010175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857010176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857010177 dimer interface [polypeptide binding]; other site 471857010178 conserved gate region; other site 471857010179 putative PBP binding loops; other site 471857010180 ABC-ATPase subunit interface; other site 471857010181 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471857010182 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471857010183 peptide binding site [polypeptide binding]; other site 471857010184 hypothetical protein; Provisional; Region: PRK06547 471857010185 recombination protein RecR; Reviewed; Region: recR; PRK00076 471857010186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857010187 RecR protein; Region: RecR; pfam02132 471857010188 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471857010189 putative active site [active] 471857010190 putative metal-binding site [ion binding]; other site 471857010191 tetramer interface [polypeptide binding]; other site 471857010192 hypothetical protein; Validated; Region: PRK00153 471857010193 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471857010194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857010195 Walker A motif; other site 471857010196 ATP binding site [chemical binding]; other site 471857010197 Walker B motif; other site 471857010198 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471857010199 Immunity protein Imm1; Region: Imm1; pfam14430 471857010200 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857010201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471857010202 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857010203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857010204 non-specific DNA binding site [nucleotide binding]; other site 471857010205 salt bridge; other site 471857010206 sequence-specific DNA binding site [nucleotide binding]; other site 471857010207 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471857010208 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471857010209 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471857010210 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471857010211 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 471857010212 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471857010213 TrkA-N domain; Region: TrkA_N; pfam02254 471857010214 TrkA-C domain; Region: TrkA_C; pfam02080 471857010215 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471857010216 substrate binding site [chemical binding]; other site 471857010217 THF binding site; other site 471857010218 zinc-binding site [ion binding]; other site 471857010219 transketolase; Reviewed; Region: PRK05899 471857010220 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471857010221 TPP-binding site [chemical binding]; other site 471857010222 dimer interface [polypeptide binding]; other site 471857010223 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857010224 PYR/PP interface [polypeptide binding]; other site 471857010225 dimer interface [polypeptide binding]; other site 471857010226 TPP binding site [chemical binding]; other site 471857010227 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857010228 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471857010229 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471857010230 metal-binding site [ion binding] 471857010231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471857010232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471857010233 metal-binding site [ion binding] 471857010234 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471857010235 putative homodimer interface [polypeptide binding]; other site 471857010236 putative homotetramer interface [polypeptide binding]; other site 471857010237 putative allosteric switch controlling residues; other site 471857010238 putative metal binding site [ion binding]; other site 471857010239 putative homodimer-homodimer interface [polypeptide binding]; other site 471857010240 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471857010241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471857010242 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857010243 G1 box; other site 471857010244 GTP/Mg2+ binding site [chemical binding]; other site 471857010245 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857010246 G3 box; other site 471857010247 Switch II region; other site 471857010248 GTP/Mg2+ binding site [chemical binding]; other site 471857010249 G4 box; other site 471857010250 G5 box; other site 471857010251 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 471857010252 nucleotide binding site [chemical binding]; other site 471857010253 putative NEF/HSP70 interaction site [polypeptide binding]; other site 471857010254 SBD interface [polypeptide binding]; other site 471857010255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857010256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857010257 DNA binding residues [nucleotide binding] 471857010258 dimerization interface [polypeptide binding]; other site 471857010259 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471857010260 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471857010261 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857010262 LGFP repeat; Region: LGFP; pfam08310 471857010263 LGFP repeat; Region: LGFP; pfam08310 471857010264 LGFP repeat; Region: LGFP; pfam08310 471857010265 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471857010266 nucleoside/Zn binding site; other site 471857010267 dimer interface [polypeptide binding]; other site 471857010268 catalytic motif [active] 471857010269 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 471857010270 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471857010271 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471857010272 metal binding site [ion binding]; metal-binding site 471857010273 dimer interface [polypeptide binding]; other site 471857010274 prephenate dehydrogenase; Validated; Region: PRK06545 471857010275 prephenate dehydrogenase; Validated; Region: PRK08507 471857010276 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 471857010277 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 471857010278 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 471857010279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857010280 putative Zn2+ binding site [ion binding]; other site 471857010281 putative DNA binding site [nucleotide binding]; other site 471857010282 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857010283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471857010284 Walker A/P-loop; other site 471857010285 ATP binding site [chemical binding]; other site 471857010286 Q-loop/lid; other site 471857010287 ABC transporter signature motif; other site 471857010288 Walker B; other site 471857010289 D-loop; other site 471857010290 H-loop/switch region; other site 471857010291 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471857010292 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471857010293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857010294 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471857010295 tetramerization interface [polypeptide binding]; other site 471857010296 NAD(P) binding site [chemical binding]; other site 471857010297 catalytic residues [active] 471857010298 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471857010299 catalytic residues [active] 471857010300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857010301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857010302 OsmC-like protein; Region: OsmC; cl00767 471857010303 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857010304 active site 471857010305 PAS domain S-box; Region: sensory_box; TIGR00229 471857010306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857010307 putative active site [active] 471857010308 heme pocket [chemical binding]; other site 471857010309 PAS fold; Region: PAS_4; pfam08448 471857010310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857010311 putative active site [active] 471857010312 heme pocket [chemical binding]; other site 471857010313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857010314 PAS domain; Region: PAS_9; pfam13426 471857010315 putative active site [active] 471857010316 heme pocket [chemical binding]; other site 471857010317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471857010318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857010319 metal binding site [ion binding]; metal-binding site 471857010320 active site 471857010321 I-site; other site 471857010322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857010323 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 471857010324 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471857010325 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 471857010326 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 471857010327 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471857010328 Cysteine-rich domain; Region: CCG; pfam02754 471857010329 Cysteine-rich domain; Region: CCG; pfam02754 471857010330 YceI-like domain; Region: YceI; pfam04264 471857010331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471857010332 DNA-binding site [nucleotide binding]; DNA binding site 471857010333 RNA-binding motif; other site 471857010334 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 471857010335 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 471857010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471857010337 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857010338 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857010339 CoenzymeA binding site [chemical binding]; other site 471857010340 subunit interaction site [polypeptide binding]; other site 471857010341 PHB binding site; other site 471857010342 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471857010343 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857010344 putative active site [active] 471857010345 putative metal binding site [ion binding]; other site 471857010346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857010347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857010348 active site 471857010349 ATP binding site [chemical binding]; other site 471857010350 substrate binding site [chemical binding]; other site 471857010351 activation loop (A-loop); other site 471857010352 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471857010353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857010354 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857010355 substrate binding pocket [chemical binding]; other site 471857010356 membrane-bound complex binding site; other site 471857010357 hinge residues; other site 471857010358 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471857010359 active site 471857010360 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471857010361 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 471857010362 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471857010363 MMPL family; Region: MMPL; pfam03176 471857010364 MMPL family; Region: MMPL; pfam03176 471857010365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471857010366 MarR family; Region: MarR_2; cl17246 471857010367 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 471857010368 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 471857010369 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471857010370 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471857010371 Ligand binding site; other site 471857010372 Putative Catalytic site; other site 471857010373 DXD motif; other site 471857010374 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471857010375 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471857010376 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471857010377 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471857010378 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 471857010379 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471857010380 active site 471857010381 metal binding site [ion binding]; metal-binding site 471857010382 nudix motif; other site 471857010383 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857010384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857010385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857010386 ATP binding site [chemical binding]; other site 471857010387 Mg2+ binding site [ion binding]; other site 471857010388 G-X-G motif; other site 471857010389 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471857010390 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857010391 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857010392 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471857010393 G2 box; other site 471857010394 Switch I region; other site 471857010395 G3 box; other site 471857010396 Switch II region; other site 471857010397 GTP/Mg2+ binding site [chemical binding]; other site 471857010398 G4 box; other site 471857010399 G5 box; other site 471857010400 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 471857010401 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857010402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857010403 catalytic residue [active] 471857010404 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 471857010405 EamA-like transporter family; Region: EamA; pfam00892 471857010406 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 471857010407 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471857010408 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471857010409 FMN binding site [chemical binding]; other site 471857010410 active site 471857010411 catalytic residues [active] 471857010412 substrate binding site [chemical binding]; other site 471857010413 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857010414 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471857010415 PhoU domain; Region: PhoU; pfam01895 471857010416 PhoU domain; Region: PhoU; pfam01895 471857010417 PBP superfamily domain; Region: PBP_like_2; cl17296 471857010418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 471857010419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857010420 dimer interface [polypeptide binding]; other site 471857010421 conserved gate region; other site 471857010422 putative PBP binding loops; other site 471857010423 ABC-ATPase subunit interface; other site 471857010424 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 471857010425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857010426 dimer interface [polypeptide binding]; other site 471857010427 conserved gate region; other site 471857010428 putative PBP binding loops; other site 471857010429 ABC-ATPase subunit interface; other site 471857010430 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471857010431 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 471857010432 Walker A/P-loop; other site 471857010433 ATP binding site [chemical binding]; other site 471857010434 Q-loop/lid; other site 471857010435 ABC transporter signature motif; other site 471857010436 Walker B; other site 471857010437 D-loop; other site 471857010438 H-loop/switch region; other site 471857010439 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471857010440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857010441 Coenzyme A binding pocket [chemical binding]; other site 471857010442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471857010443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857010444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471857010445 DNA binding site [nucleotide binding] 471857010446 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 471857010447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857010448 catalytic residues [active] 471857010449 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 471857010450 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471857010451 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471857010452 active site residue [active] 471857010453 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471857010454 active site residue [active] 471857010455 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 471857010456 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471857010457 heme-binding site [chemical binding]; other site 471857010458 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471857010459 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 471857010460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857010461 catalytic residue [active] 471857010462 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471857010463 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471857010464 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857010465 L-asparaginase II; Region: Asparaginase_II; pfam06089 471857010466 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471857010467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857010468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471857010469 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 471857010470 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 471857010471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 471857010472 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471857010473 PAS domain; Region: PAS; smart00091 471857010474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857010475 ATP binding site [chemical binding]; other site 471857010476 Mg2+ binding site [ion binding]; other site 471857010477 G-X-G motif; other site 471857010478 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471857010479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857010480 active site 471857010481 phosphorylation site [posttranslational modification] 471857010482 intermolecular recognition site; other site 471857010483 dimerization interface [polypeptide binding]; other site 471857010484 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471857010485 hypothetical protein; Provisional; Region: PRK09256 471857010486 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471857010487 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471857010488 dimerization interface [polypeptide binding]; other site 471857010489 putative ATP binding site [chemical binding]; other site 471857010490 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471857010491 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471857010492 active site 471857010493 tetramer interface [polypeptide binding]; other site 471857010494 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857010495 active site 471857010496 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857010497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857010498 non-specific DNA binding site [nucleotide binding]; other site 471857010499 salt bridge; other site 471857010500 sequence-specific DNA binding site [nucleotide binding]; other site 471857010501 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 471857010502 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471857010503 active site 471857010504 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 471857010505 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471857010506 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471857010507 dimerization interface [polypeptide binding]; other site 471857010508 ATP binding site [chemical binding]; other site 471857010509 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471857010510 dimerization interface [polypeptide binding]; other site 471857010511 ATP binding site [chemical binding]; other site 471857010512 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 471857010513 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471857010514 putative active site [active] 471857010515 catalytic triad [active] 471857010516 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 471857010517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857010518 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 471857010519 NAD(P) binding site [chemical binding]; other site 471857010520 catalytic residues [active] 471857010521 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471857010522 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 471857010523 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471857010524 adenylosuccinate lyase; Region: purB; TIGR00928 471857010525 tetramer interface [polypeptide binding]; other site 471857010526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857010527 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857010528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857010529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857010530 DNA binding residues [nucleotide binding] 471857010531 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 471857010532 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857010533 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857010534 catalytic residue [active] 471857010535 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471857010536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857010537 motif II; other site 471857010538 aspartate aminotransferase; Provisional; Region: PRK05764 471857010539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857010540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857010541 homodimer interface [polypeptide binding]; other site 471857010542 catalytic residue [active] 471857010543 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471857010544 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471857010545 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857010546 catalytic residue [active] 471857010547 EspG family; Region: ESX-1_EspG; pfam14011 471857010548 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471857010549 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471857010550 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471857010551 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471857010552 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 471857010553 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 471857010554 putative active site [active] 471857010555 catalytic site [active] 471857010556 putative metal binding site [ion binding]; other site 471857010557 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471857010558 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471857010559 GDP-binding site [chemical binding]; other site 471857010560 ACT binding site; other site 471857010561 IMP binding site; other site 471857010562 lipid kinase; Reviewed; Region: PRK13054 471857010563 Secretory lipase; Region: LIP; pfam03583 471857010564 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471857010565 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 471857010566 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471857010567 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 471857010568 active site 471857010569 intersubunit interface [polypeptide binding]; other site 471857010570 zinc binding site [ion binding]; other site 471857010571 Na+ binding site [ion binding]; other site 471857010572 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 471857010573 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 471857010574 short chain dehydrogenase; Provisional; Region: PRK05872 471857010575 classical (c) SDRs; Region: SDR_c; cd05233 471857010576 NAD(P) binding site [chemical binding]; other site 471857010577 active site 471857010578 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471857010579 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857010580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857010581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857010582 DNA binding residues [nucleotide binding] 471857010583 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 471857010584 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471857010585 active site 471857010586 dimer interface [polypeptide binding]; other site 471857010587 FAD binding domain; Region: FAD_binding_4; pfam01565 471857010588 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471857010589 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471857010590 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857010591 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 471857010592 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471857010593 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857010594 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471857010595 substrate binding site [chemical binding]; other site 471857010596 ATP binding site [chemical binding]; other site 471857010597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857010598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857010599 DNA binding site [nucleotide binding] 471857010600 domain linker motif; other site 471857010601 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857010602 dimerization interface [polypeptide binding]; other site 471857010603 ligand binding site [chemical binding]; other site 471857010604 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 471857010605 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 471857010606 active site 471857010607 Fe(II) binding site [ion binding]; other site 471857010608 dimer interface [polypeptide binding]; other site 471857010609 tetramer interface [polypeptide binding]; other site 471857010610 Subunit A of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and similar enzymes; Region: PCA_45_Doxase_A_like; cd07921 471857010611 dimer interface [polypeptide binding]; other site 471857010612 tetramer interface [polypeptide binding]; other site 471857010613 active site 471857010614 Muconolactone delta-isomerase; Region: MIase; cl01992 471857010615 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857010616 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 471857010617 hypothetical protein; Provisional; Region: PRK09262 471857010618 hypothetical protein; Validated; Region: PRK06201 471857010619 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 471857010620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857010621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857010622 active site 471857010623 phosphorylation site [posttranslational modification] 471857010624 intermolecular recognition site; other site 471857010625 dimerization interface [polypeptide binding]; other site 471857010626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857010627 DNA binding residues [nucleotide binding] 471857010628 dimerization interface [polypeptide binding]; other site 471857010629 PAS domain S-box; Region: sensory_box; TIGR00229 471857010630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857010631 putative active site [active] 471857010632 heme pocket [chemical binding]; other site 471857010633 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857010634 GAF domain; Region: GAF_3; pfam13492 471857010635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857010636 Histidine kinase; Region: HisKA_3; pfam07730 471857010637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857010638 ATP binding site [chemical binding]; other site 471857010639 Mg2+ binding site [ion binding]; other site 471857010640 G-X-G motif; other site 471857010641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857010642 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857010643 putative substrate translocation pore; other site 471857010644 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857010645 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857010646 NAD(P) binding site [chemical binding]; other site 471857010647 catalytic residues [active] 471857010648 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857010649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471857010650 S-adenosylmethionine binding site [chemical binding]; other site 471857010651 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471857010652 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471857010653 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 471857010654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471857010655 active site 471857010656 classical (c) SDRs; Region: SDR_c; cd05233 471857010657 NAD(P) binding site [chemical binding]; other site 471857010658 active site 471857010659 anthranilate synthase; Provisional; Region: PRK13566 471857010660 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471857010661 Clp amino terminal domain; Region: Clp_N; pfam02861 471857010662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857010663 Walker A motif; other site 471857010664 ATP binding site [chemical binding]; other site 471857010665 Walker B motif; other site 471857010666 arginine finger; other site 471857010667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471857010668 Walker A motif; other site 471857010669 ATP binding site [chemical binding]; other site 471857010670 Walker B motif; other site 471857010671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471857010672 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471857010673 heme-binding site [chemical binding]; other site 471857010674 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 471857010675 FMN reductase; Validated; Region: fre; PRK08051 471857010676 FAD binding pocket [chemical binding]; other site 471857010677 FAD binding motif [chemical binding]; other site 471857010678 phosphate binding motif [ion binding]; other site 471857010679 beta-alpha-beta structure motif; other site 471857010680 NAD binding pocket [chemical binding]; other site 471857010681 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471857010682 DNA binding residues [nucleotide binding] 471857010683 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471857010684 putative dimer interface [polypeptide binding]; other site 471857010685 chaperone protein DnaJ; Provisional; Region: PRK14279 471857010686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471857010687 HSP70 interaction site [polypeptide binding]; other site 471857010688 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471857010689 Zn binding sites [ion binding]; other site 471857010690 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471857010691 dimer interface [polypeptide binding]; other site 471857010692 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471857010693 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 471857010694 dimer interface [polypeptide binding]; other site 471857010695 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471857010696 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471857010697 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471857010698 nucleotide binding site [chemical binding]; other site 471857010699 NEF interaction site [polypeptide binding]; other site 471857010700 SBD interface [polypeptide binding]; other site 471857010701 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471857010702 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471857010703 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471857010704 substrate binding site [chemical binding]; other site 471857010705 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857010706 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 471857010707 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857010708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857010709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857010710 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471857010711 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471857010712 4Fe-4S binding domain; Region: Fer4; pfam00037 471857010713 Cysteine-rich domain; Region: CCG; pfam02754 471857010714 Cysteine-rich domain; Region: CCG; pfam02754 471857010715 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857010716 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 471857010717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857010718 active site 471857010719 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 471857010720 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471857010721 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471857010722 trimer interface [polypeptide binding]; other site 471857010723 active site 471857010724 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 471857010725 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857010726 VanZ like family; Region: VanZ; pfam04892 471857010727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857010728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 471857010729 active site 471857010730 phosphorylation site [posttranslational modification] 471857010731 dimerization interface [polypeptide binding]; other site 471857010732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857010733 DNA binding residues [nucleotide binding] 471857010734 dimerization interface [polypeptide binding]; other site 471857010735 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 471857010736 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 471857010737 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 471857010738 FAD binding site [chemical binding]; other site 471857010739 substrate binding site [chemical binding]; other site 471857010740 catalytic residues [active] 471857010741 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 471857010742 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471857010743 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471857010744 oligomerisation interface [polypeptide binding]; other site 471857010745 mobile loop; other site 471857010746 roof hairpin; other site 471857010747 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857010748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471857010749 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471857010750 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471857010751 Walker A/P-loop; other site 471857010752 ATP binding site [chemical binding]; other site 471857010753 Q-loop/lid; other site 471857010754 ABC transporter signature motif; other site 471857010755 Walker B; other site 471857010756 D-loop; other site 471857010757 H-loop/switch region; other site 471857010758 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471857010760 dimer interface [polypeptide binding]; other site 471857010761 conserved gate region; other site 471857010762 putative PBP binding loops; other site 471857010763 ABC-ATPase subunit interface; other site 471857010764 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857010765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471857010766 substrate binding pocket [chemical binding]; other site 471857010767 membrane-bound complex binding site; other site 471857010768 hinge residues; other site 471857010769 hypothetical protein; Provisional; Region: PRK07907 471857010770 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 471857010771 metal binding site [ion binding]; metal-binding site 471857010772 putative dimer interface [polypeptide binding]; other site 471857010773 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471857010774 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471857010775 TPP-binding site [chemical binding]; other site 471857010776 tetramer interface [polypeptide binding]; other site 471857010777 heterodimer interface [polypeptide binding]; other site 471857010778 phosphorylation loop region [posttranslational modification] 471857010779 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471857010780 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471857010781 alpha subunit interface [polypeptide binding]; other site 471857010782 TPP binding site [chemical binding]; other site 471857010783 heterodimer interface [polypeptide binding]; other site 471857010784 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857010785 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471857010786 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857010787 E3 interaction surface; other site 471857010788 lipoyl attachment site [posttranslational modification]; other site 471857010789 e3 binding domain; Region: E3_binding; pfam02817 471857010790 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471857010791 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 471857010792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857010793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857010794 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857010795 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857010796 active site 2 [active] 471857010797 active site 1 [active] 471857010798 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 471857010799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857010800 NAD(P) binding site [chemical binding]; other site 471857010801 active site 471857010802 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 471857010803 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857010804 dimer interface [polypeptide binding]; other site 471857010805 active site 471857010806 Predicted transcriptional regulator [Transcription]; Region: COG2345 471857010807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857010808 putative DNA binding site [nucleotide binding]; other site 471857010809 putative Zn2+ binding site [ion binding]; other site 471857010810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471857010811 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857010812 Walker A/P-loop; other site 471857010813 ATP binding site [chemical binding]; other site 471857010814 Q-loop/lid; other site 471857010815 ABC transporter signature motif; other site 471857010816 Walker B; other site 471857010817 D-loop; other site 471857010818 H-loop/switch region; other site 471857010819 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471857010820 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471857010821 Predicted membrane protein [Function unknown]; Region: COG2259 471857010822 Septum formation; Region: Septum_form; pfam13845 471857010823 Septum formation; Region: Septum_form; pfam13845 471857010824 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 471857010825 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 471857010826 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 471857010827 tetramer interface [polypeptide binding]; other site 471857010828 active site 471857010829 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 471857010830 active site 471857010831 homotetramer interface [polypeptide binding]; other site 471857010832 homodimer interface [polypeptide binding]; other site 471857010833 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 471857010834 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857010835 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857010836 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471857010837 active site 471857010838 substrate-binding site [chemical binding]; other site 471857010839 metal-binding site [ion binding] 471857010840 GTP binding site [chemical binding]; other site 471857010841 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857010842 Dynamin family; Region: Dynamin_N; pfam00350 471857010843 G1 box; other site 471857010844 GTP/Mg2+ binding site [chemical binding]; other site 471857010845 Switch I region; other site 471857010846 G3 box; other site 471857010847 Switch II region; other site 471857010848 G4 box; other site 471857010849 G5 box; other site 471857010850 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471857010851 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471857010852 Dynamin family; Region: Dynamin_N; pfam00350 471857010853 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471857010854 G1 box; other site 471857010855 GTP/Mg2+ binding site [chemical binding]; other site 471857010856 G2 box; other site 471857010857 Switch I region; other site 471857010858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857010859 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471857010860 Walker A/P-loop; other site 471857010861 ATP binding site [chemical binding]; other site 471857010862 Q-loop/lid; other site 471857010863 ABC transporter signature motif; other site 471857010864 Walker B; other site 471857010865 D-loop; other site 471857010866 H-loop/switch region; other site 471857010867 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471857010868 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 471857010869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857010870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471857010871 Walker A/P-loop; other site 471857010872 ATP binding site [chemical binding]; other site 471857010873 Q-loop/lid; other site 471857010874 ABC transporter signature motif; other site 471857010875 Walker B; other site 471857010876 D-loop; other site 471857010877 H-loop/switch region; other site 471857010878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857010879 Histidine kinase; Region: HisKA_3; pfam07730 471857010880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857010881 ATP binding site [chemical binding]; other site 471857010882 Mg2+ binding site [ion binding]; other site 471857010883 G-X-G motif; other site 471857010884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857010885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857010886 active site 471857010887 phosphorylation site [posttranslational modification] 471857010888 intermolecular recognition site; other site 471857010889 dimerization interface [polypeptide binding]; other site 471857010890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857010891 DNA binding residues [nucleotide binding] 471857010892 dimerization interface [polypeptide binding]; other site 471857010893 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 471857010894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471857010895 active site 471857010896 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471857010897 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471857010898 Walker A/P-loop; other site 471857010899 ATP binding site [chemical binding]; other site 471857010900 Q-loop/lid; other site 471857010901 ABC transporter signature motif; other site 471857010902 Walker B; other site 471857010903 D-loop; other site 471857010904 H-loop/switch region; other site 471857010905 Predicted transcriptional regulators [Transcription]; Region: COG1725 471857010906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857010907 DNA-binding site [nucleotide binding]; DNA binding site 471857010908 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 471857010909 Protein of unknown function (DUF461); Region: DUF461; pfam04314 471857010910 short chain dehydrogenase; Provisional; Region: PRK08219 471857010911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857010912 NAD(P) binding site [chemical binding]; other site 471857010913 active site 471857010914 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 471857010915 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471857010916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471857010917 motif II; other site 471857010918 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 471857010919 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 471857010920 Predicted transcriptional regulators [Transcription]; Region: COG1695 471857010921 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471857010922 Transglycosylase; Region: Transgly; pfam00912 471857010923 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471857010924 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471857010925 Predicted integral membrane protein [Function unknown]; Region: COG5650 471857010926 endonuclease IV; Provisional; Region: PRK01060 471857010927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471857010928 AP (apurinic/apyrimidinic) site pocket; other site 471857010929 DNA interaction; other site 471857010930 Metal-binding active site; metal-binding site 471857010931 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471857010932 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471857010933 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471857010934 dimer interface [polypeptide binding]; other site 471857010935 ssDNA binding site [nucleotide binding]; other site 471857010936 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471857010937 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471857010938 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471857010939 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471857010940 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471857010941 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 471857010942 EspG family; Region: ESX-1_EspG; pfam14011 471857010943 replicative DNA helicase; Region: DnaB; TIGR00665 471857010944 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471857010945 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471857010946 Walker A motif; other site 471857010947 ATP binding site [chemical binding]; other site 471857010948 Walker B motif; other site 471857010949 DNA binding loops [nucleotide binding] 471857010950 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 471857010951 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 471857010952 putative active site [active] 471857010953 metal binding site [ion binding]; metal-binding site 471857010954 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471857010955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857010956 ATP binding site [chemical binding]; other site 471857010957 Mg2+ binding site [ion binding]; other site 471857010958 G-X-G motif; other site 471857010959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857010960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471857010961 active site 471857010962 phosphorylation site [posttranslational modification] 471857010963 intermolecular recognition site; other site 471857010964 dimerization interface [polypeptide binding]; other site 471857010965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471857010966 DNA binding residues [nucleotide binding] 471857010967 dimerization interface [polypeptide binding]; other site 471857010968 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857010969 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471857010970 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471857010971 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471857010972 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471857010973 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471857010974 substrate binding site [chemical binding]; other site 471857010975 dimer interface [polypeptide binding]; other site 471857010976 ATP binding site [chemical binding]; other site 471857010977 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471857010978 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857010979 active site 471857010980 HIGH motif; other site 471857010981 nucleotide binding site [chemical binding]; other site 471857010982 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471857010983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857010984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857010985 active site 471857010986 KMSKS motif; other site 471857010987 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471857010988 tRNA binding surface [nucleotide binding]; other site 471857010989 SdpI/YhfL protein family; Region: SdpI; pfam13630 471857010990 hypothetical protein; Validated; Region: PRK00228 471857010991 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 471857010992 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471857010993 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471857010994 active site 471857010995 NTP binding site [chemical binding]; other site 471857010996 metal binding triad [ion binding]; metal-binding site 471857010997 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471857010998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471857010999 Zn2+ binding site [ion binding]; other site 471857011000 Mg2+ binding site [ion binding]; other site 471857011001 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471857011002 active site 471857011003 Ap6A binding site [chemical binding]; other site 471857011004 nudix motif; other site 471857011005 metal binding site [ion binding]; metal-binding site 471857011006 integral membrane protein MviN; Region: mviN; TIGR01695 471857011007 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471857011008 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471857011009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857011010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471857011011 DNA binding residues [nucleotide binding] 471857011012 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471857011013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471857011014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471857011015 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857011016 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471857011017 catalytic residues [active] 471857011018 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471857011019 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857011020 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857011021 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471857011022 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471857011023 active site 471857011024 metal binding site [ion binding]; metal-binding site 471857011025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857011026 Coenzyme A binding pocket [chemical binding]; other site 471857011027 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471857011028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857011029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857011030 homodimer interface [polypeptide binding]; other site 471857011031 catalytic residue [active] 471857011032 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471857011033 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471857011034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471857011035 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471857011036 ParB-like nuclease domain; Region: ParBc; pfam02195 471857011037 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857011038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857011039 P-loop; other site 471857011040 Magnesium ion binding site [ion binding]; other site 471857011041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471857011042 Magnesium ion binding site [ion binding]; other site 471857011043 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471857011044 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 471857011045 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 471857011046 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471857011047 G-X-X-G motif; other site 471857011048 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471857011049 RxxxH motif; other site 471857011050 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471857011051 Haemolytic domain; Region: Haemolytic; pfam01809 471857011052 Ribonuclease P; Region: Ribonuclease_P; cl00457 471857011053 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399