-- dump date 20240506_011914 -- class Genbank::CDS -- table cds_function -- id function BN6_RS00030 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings,including catenanes and knotted rings BN6_RS00035 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings,including catenanes and knotted rings BN6_RS00120 Cell division protein FtsI/penicillin-binding protein 2 BN6_RS00130 The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA BN6_RS00135 FOG: FHA domain BN6_RS49440 FOG: FHA domain BN6_RS00280 Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid BN6_RS00305 GDP-D-mannose dehydratase BN6_RS00330 Glycosyltransferase BN6_RS00505 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS00520 Iron-storage protein (Potential) BN6_RS00780 Glycosyltransferases involved in cell wall biogenesis BN6_RS00795 Glycosyltransferases involved in cell wall biogenesis BN6_RS00815 Predicted glycosyltransferases BN6_RS00830 Predicted glycosyltransferases BN6_RS00865 May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent naphtoquinone reductase activity, with a preference for 1,2-naphtoquinone over 1,4- naphtoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) BN6_RS00915 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase BN6_RS00940 Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA BN6_RS01110 Cytosine/adenosine deaminases BN6_RS01195 Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane BN6_RS01205 This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though,unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system BN6_RS01230 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) BN6_RS01250 Aspartokinases BN6_RS01275 Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide BN6_RS01350 membrane carboxypeptidase (penicillin-binding protein) BN6_RS01475 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain BN6_RS01515 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA),respectively BN6_RS01705 Hypoxanthine-guaninephosphoribosyltransferase BN6_RS01785 Panthothenate synthetase BN6_RS01950 FOG: GGDEF domain BN6_RS01955 Permeases of the major facilitator superfamily BN6_RS01960 Predicted membrane protein involved in D-alanine export BN6_RS01965 rRNA methylases BN6_RS01975 Predicted hydrolase (HAD superfamily) BN6_RS01980 Predicted flavin-nucleotide-binding protein BN6_RS01990 4-diphosphocytidyl-2-methyl-D- erithritolsynthase BN6_RS01995 Transcriptional regulators, similar to M. xanthus CarD BN6_RS02020 Trehalose-6-phosphate synthase BN6_RS02125 Transcriptional regulator/sugar kinase BN6_RS02135 Predicted N-acetylglucosamine kinase BN6_RS02220 Exhibits dehydratase activity specific for L-threo-3- hydroxyaspartate BN6_RS02230 Signal transduction histidine kinase BN6_RS02265 Predicted O-methyltransferase BN6_RS02405 Aerobic-type carbon monoxide dehydrogenase,large subunit, CoxL/CutL homolog BN6_RS02510 In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate BN6_RS02655 Destroys radicals which are normally produced within the cells and which are toxic to biological systems BN6_RS02795 Involved in the degradation of long-chain fatty acids BN6_RS02875 Putative quinone oxidoreductase that may contribute to the degradation of aromatic compounds (Potential) BN6_RS03170 Protein related to penicillin acylase BN6_RS03295 Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA,qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration BN6_RS03390 Hydrolysis of proteins with specificity similar to chymotrypsin. May be specialized for the degradation of chitin- linked proteins. Has a primary specificity for large aliphatic or aromatic amino acids BN6_RS03430 Mg-dependent DNase BN6_RS03465 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase BN6_RS03610 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS03675 Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system BN6_RS03680 This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though,unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system BN6_RS03810 Involved in the degradation of long-chain fatty acids BN6_RS03815 Lysophospholipase L1 BN6_RS03880 Highly conserved protein containing a thioredoxin domain BN6_RS03955 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs BN6_RS04015 Penicillin tolerance protein BN6_RS04190 This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though,unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system BN6_RS04220 Aspartate/tyrosine/aromatic aminotransferase BN6_RS04225 Tetrahydrodipicolinate N-succinyltransferase BN6_RS04315 Glycosyltransferase BN6_RS04330 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS04565 Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP),followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown BN6_RS04735 Geranylgeranyl pyrophosphate synthase BN6_RS04845 Specifically catalyzes the removal of N-terminal proline residues from peptides BN6_RS04865 Confers resistance to ethidium bromide. Requires lprG lipoprotein for normal function BN6_RS05070 Part of the ABC transporter FtsEX involved in sporulation. May act as an importer, possibly at the top of a hierarchical cascade leading to the correct temporal initiation of sporulation. Acts upstream of the histidine kinases KinA, KinB and KinC, the RapA phosphatase and the Spo0A sporulation protein BN6_RS05105 Glycosyltransferases involved in cell wall biogenesis BN6_RS05230 Predicted ATPase BN6_RS05280 Glycosyltransferases involved in cell wall biogenesis BN6_RS05355 May be involved in active puromycin efflux energized by a proton-dependent electrochemical gradient. In addition, it could be implicated in secreting N-acetylpuromycin, the last intermediate of the puromycin biosynthesis pathway, to the environment BN6_RS05445 ABC-type phosphate transport system,periplasmic component BN6_RS05525 Rhs family protein BN6_RS05550 Neuraminidase (sialidase) BN6_RS41600 DNA-binding transcriptional activator of the SARP family BN6_RS05565 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS05575 Permeases of the major facilitator superfamily BN6_RS05585 NADPH:quinone reductase and related Zn-dependent oxidoreductases BN6_RS05590 DNA-binding HTH domain-containing proteins BN6_RS05595 N-acetyl-beta-hexosaminidase BN6_RS05725 Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO BN6_RS05735 Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis BN6_RS05995 uncharacterized conserved protein BN6_RS06100 Essential for pSAM2 replication BN6_RS06225 FOG: TPR repeat BN6_RS06325 Predicted transcriptional regulators BN6_RS06365 N-acetyl-beta-hexosaminidase BN6_RS06400 Predicted metal-dependent hydrolase with the TIM-barrel fold BN6_RS06415 uncharacterized protein conserved in cyanobacteria BN6_RS06495 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP BN6_RS06520 Involved in arginine catabolism by converting L-glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family BN6_RS06575 Required for the transposition of the insertion element (Potential) BN6_RS06620 Aminopeptidase with broad substrate specificity to several peptides. Shows strong preference for leucine but cleaves also next to Arg and lysine in peptide-bond-containing substrates BN6_RS06625 Predicted oxidoreductase BN6_RS06780 Protease subunit of ATP-dependent Clp proteases BN6_RS06785 Protease subunit of ATP-dependent Clp proteases BN6_RS06925 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate BN6_RS07175 Dioxygenases related to 2-nitropropane dioxygenase BN6_RS07220 Enoyl-CoA hydratase/carnithine racemase BN6_RS07280 Sulfite reductase, beta subunit (hemoprotein) BN6_RS07485 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis BN6_RS07555 Glycosyltransferases, probably involved in cell wall biogenesis BN6_RS07595 Predicted drug exporters of the RND superfamily BN6_RS07695 ABC-type multidrug transport system, ATPase and permease components BN6_RS07700 ABC-type bacteriocin/lantibiotic exporters,contain an N-terminal double-glycine peptidase domain BN6_RS07715 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS07725 3-oxoacyl-[acyl-carrier-protein] synthase III BN6_RS07740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS07855 The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) BN6_RS07875 Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val BN6_RS07885 NaMN:DMB phosphoribosyltransferase BN6_RS07900 Probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit BN6_RS07985 Component of the menaquinol-cytochrome c reductase complex BN6_RS07990 Component of the ubiquinol-cytochrome c reductase complex. The Rieske protein is a high potential 2Fe-2S protein BN6_RS08000 Transcriptional regulators BN6_RS08030 Predicted ATPase BN6_RS08065 Required for glucose repression of many different genes BN6_RS08105 Phytoene/squalene synthetase BN6_RS08115 Phytoene dehydrogenase and related proteins BN6_RS08120 Geranylgeranyl pyrophosphate synthase BN6_RS08225 Uncharacterized conserved protein, contains double-stranded beta-helix domain BN6_RS08580 Probably part of the phnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane BN6_RS08605 RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester BN6_RS08645 Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism BN6_RS08705 It functions in the generation of fumarate for use as an anaerobic electron acceptor BN6_RS08795 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium BN6_RS08800 Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor BN6_RS08900 Deoxyxylulose-5-phosphate synthase BN6_RS08955 AraC-type DNA-binding domain-containing proteins BN6_RS08960 predicted nucleoside-diphosphate-sugar epimerases BN6_RS09150 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX BN6_RS09275 Uncharacterized protein, contains Trp-Asp (WD) repeat BN6_RS09340 uncharacterized protein conserved in bacteria BN6_RS09350 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS09785 The FAS-operon encodes genes involved in cytokinin production and in host plant fasciation (leafy gall) BN6_RS10040 Predicted ATPase BN6_RS41735 Signal transduction histidine kinase BN6_RS10345 Essential enzyme that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain of fatty acids BN6_RS10400 Acts on both enantiomers of limonene by their NAD- dependent epoxidation at the 1,2 double bond forming limonene-1,2- epoxide BN6_RS10425 Catalyzes aldol condensation between L-aspartate-4- semialdehyde (ASA) and dihydroxyacetone phosphate (DHAP), to form 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate BN6_RS10450 Global regulatory protein for secondary metabolite formation BN6_RS10740 Glycosyltransferases, probably involved in cell wall biogenesis BN6_RS48570 predicted ATPase BN6_RS10870 Permeases of the major facilitator superfamily BN6_RS10875 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10880 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10885 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10890 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10895 Predicted carbamoyl transferase, NodU family BN6_RS10910 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10920 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10925 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10935 Non-ribosomal peptide synthetase modules and related proteins BN6_RS10945 Rhs family protein BN6_RS11075 Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs BN6_RS49540 Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs BN6_RS11125 Part of the ABC transporter complex yfiYZ/yfhA/yusV involved in import of the iron-hydroxamate siderophores schizokinen, arthrobactin and corprogen (Probable) BN6_RS11140 ABC-type Fe3+-hydroxamate transport system BN6_RS11370 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS11380 Glutamate decarboxylase and related PLP-dependent proteins BN6_RS11465 77 Permeases of the major facilitator superfamily BN6_RS11685 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine BN6_RS11790 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP BN6_RS11910 4.2.A.1 : The Major Facilitator Superfamily (MFS) BN6_RS11965 Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA- 824 BN6_RS12000 Involved in protein export BN6_RS12005 Involved in protein export BN6_RS12155 Aqualysin I is a thermophilic alkaline serine protease BN6_RS12170 Serine proteinase with preferred activity for amino acids with aromatic side groups at the P1' side of the scissible bond BN6_RS12205 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family BN6_RS12215 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family BN6_RS12270 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes BN6_RS12275 dTDP-D-glucose 4,6-dehydratase BN6_RS12295 This membrane protein may function as a sensor protein and may transfer the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of the genes BN6_RS12335 Glycosyltransferases involved in cell wall biogenesis BN6_RS12370 Teichoic acid biosynthesis proteins BN6_RS12375 Predicted glycosyltransferases BN6_RS12400 predicted ATPase BN6_RS12450 COG1835: Predicted acyltransferases BN6_RS12515 Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 BN6_RS12530 Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid BN6_RS12565 Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose BN6_RS12575 Required for the transposition of the insertion element (Potential) BN6_RS12650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain BN6_RS12655 Signal transduction histidine kinase BN6_RS12660 ABC-type multidrug transport system, ATPase component BN6_RS13010 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS13020 Predicted dienelactone hydrolase BN6_RS13025 Transcriptional regulator BN6_RS13030 Uncharacterized protein conserved in bacteria BN6_RS13045 Permeases of the major facilitator superfamily BN6_RS13050 Non-ribosomal peptide synthetase modules and related proteins BN6_RS13060 Non-ribosomal peptide synthetase modules and related proteins BN6_RS13065 ABC-type Fe3+-hydroxamate transport system,periplasmic component BN6_RS13070 ABC-type Fe3+-hydroxamate transport system,periplasmic component BN6_RS13075 ABC-type Fe3+-siderophore transport system,permease component BN6_RS13080 ABC-type enterobactin transport system,permease component BN6_RS13085 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS13090 Anthranilate/para-aminobenzoate synthases component I BN6_RS13095 Peptide arylation enzymes BN6_RS13100 Isochorismate hydrolase BN6_RS47765 Polyketide synthase modules and related proteins BN6_RS13365 Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds BN6_RS13380 Catalyzes the CoA transfer from succinate to 3-oxoadipate (beta-ketoadipate) BN6_RS13510 Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system BN6_RS13535 Predicted transcriptional regulators BN6_RS13750 Required for the transposition of the insertion element (Potential) BN6_RS13820 AraC-type DNA-binding domain-containing proteins BN6_RS14045 Catalyzes the hydroxylation of sodium ML-236B carboxylate to pravastatin BN6_RS14140 Folylpolyglutamate synthase BN6_RS14370 Glycosyltransferase BN6_RS14380 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) BN6_RS14595 Predicted transcriptional regulators BN6_RS14670 Catalyzes the NAD-dependent dehydration of beta-hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5- 6.5. The reverse reaction is able to use NADPH as well as NADH BN6_RS14720 Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues BN6_RS14735 Catalyzes the acylation to the position 6 of the alpha- 1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1) BN6_RS14740 Glycosyltransferase BN6_RS14960 Not known, probably involved in the catabolism of octane and guaiacol. It displays a weak activity in the O-dealkylation of 7-ethoxycoumarin BN6_RS15185 Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide BN6_RS15190 Catalyzes the ferrous insertion into protoporphyrin IX BN6_RS15375 Transcriptional regulator BN6_RS15555 Part of the pafABC operon, however pafB does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro BN6_RS15580 Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is involved in the biosynthesis of phosphatidylinositol mannosides (PIMs),probably via a role in the biosynthesis of phosphatidylinositol (PI), a PIM precursor, which is derived from phosphatidic acid. Is also able to phosphorylate other various amphipathic lipids of host and bacterial origin in vitro, such as ceramide BN6_RS15625 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS15630 putative intracellular protease/amidase BN6_RS15655 Carboxylesterase type B BN6_RS15685 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS15690 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS15700 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS15715 3-oxoacyl-[acyl-carrier protein] reductase BN6_RS15720 2-hydroxychromene-2-carboxylate isomerase BN6_RS15730 Uncharacterized ABC-type transport system,ATPase component BN6_RS15740 Transcriptional regulator BN6_RS15745 3-oxoacyl-[acyl-carrier-protein] synthase III BN6_RS15775 Acyl-CoA dehydrogenases BN6_RS15785 Pyruvate/2-oxoglutarate dehydrogenase complex,dihydrolipoamide dehydrogenase (E3) component, and related enzymes BN6_RS15800 Non-ribosomal peptide synthetase modules and related proteins BN6_RS15805 ABC-type multidrug transport system, permease component BN6_RS15810 Cytochrome P450 BN6_RS15815 Uncharacterized protein conserved in bacteria BN6_RS15820 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component BN6_RS15845 Permeases of the major facilitator superfamily BN6_RS15850 Non-ribosomal peptide synthetase modules and related proteins BN6_RS15855 Non-ribosomal peptide synthetase modules and related proteins BN6_RS16050 Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system BN6_RS16210 Non-ribosomal peptide synthetase modules and related proteins BN6_RS16235 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS16240 membrane protease subunits, stomatin/prohibitin family BN6_RS43755 Penicillin tolerance protein BN6_RS16255 Polyketide synthase modules and related proteins BN6_RS16270 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases BN6_RS16280 Predicted NAD/FAD-binding protein BN6_RS16285 Cytochrome P450 BN6_RS41995 Esterase/lipase BN6_RS16315 Polyketide synthase modules and related proteins BN6_RS16320 Choline dehydrogenase and related flavoproteins BN6_RS16330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS16340 3-oxoacyl-[acyl-carrier-protein] synthase III BN6_RS16345 Polyketide synthase modules and related proteins BN6_RS43760 Acyl carrier protein BN6_RS16470 Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane BN6_RS16525 predicted aminopeptidases BN6_RS16530 Cytochrome P450 BN6_RS16560 Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) BN6_RS16565 Dihydrodipicolinate synthase/N-acetylneuraminate lyase BN6_RS48825 Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system BN6_RS16935 4.3.A.1.m : membrane component BN6_RS16940 4.3.A.1 : The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases BN6_RS16970 Possible cation transporter BN6_RS17035 Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A BN6_RS17145 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases BN6_RS42970 Non-ribosomal peptide synthetase modules and related proteins BN6_RS17155 Polyketide synthase modules and related proteins BN6_RS17160 3-hydroxyacyl-CoA dehydrogenase BN6_RS17170 Acyl-CoA dehydrogenases BN6_RS17185 Non-ribosomal peptide synthetase modules and related proteins BN6_RS17190 Permeases of the major facilitator superfamily BN6_RS17195 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS17200 3-oxoacyl-[acyl-carrier-protein] synthase III BN6_RS17230 SAM-dependent methyltransferases BN6_RS17235 Non-ribosomal peptide synthetase modules and related proteins BN6_RS17240 Permeases of the major facilitator superfamily BN6_RS17245 Non-ribosomal peptide synthetase modules and related proteins BN6_RS17255 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS17260 Non-ribosomal peptide synthetase modules and related proteins BN6_RS17270 Uncharacterized protein conserved in bacteria BN6_RS17275 Predicted phosphohydrolases BN6_RS17280 Transcriptional regulator BN6_RS17290 Glutamate decarboxylase and related PLP-dependent proteins BN6_RS17295 Na+/melibiose symporter and related transporters BN6_RS17355 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS17360 putative intracellular protease/amidase BN6_RS17600 Superfamily I DNA and RNA helicases BN6_RS17985 Predicted ATPase BN6_RS17990 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS18000 ABC-type amino acid transport system, permease component BN6_RS18005 ABC-type sugar transport systems, ATPase components BN6_RS18010 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain BN6_RS18015 AraC-type DNA-binding domain-containing proteins BN6_RS18035 Uncharacterized conserved protein BN6_RS18040 Uncharacterized conserved protein BN6_RS18050 Transcriptional regulator BN6_RS18055 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] BN6_RS18060 Permeases of the major facilitator superfamily BN6_RS18075 Aminopeptidase N BN6_RS18085 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS18090 FOG: WD40 repeat BN6_RS18095 Predicted ATPase BN6_RS18140 ABC-type sugar transport system, permease component BN6_RS18145 ABC-type sugar transport systems, permease components BN6_RS18150 Predicted phosphohydrolases BN6_RS18155 ABC-type sugar transport system, periplasmic component BN6_RS18165 Metal-dependent hydrolases of the beta-lactamase superfamily III BN6_RS18170 UDP-N-acetyl-D-mannosaminuronatedehydrogenase BN6_RS18235 Transforms O-acetylhomoserine into homocysteine BN6_RS18255 4.3.A.1.m : membrane component BN6_RS18350 Putative quinone oxidoreductase that may contribute to the degradation of aromatic compounds (Potential) BN6_RS18360 predicted transcriptional regulators BN6_RS18545 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS18555 Glycosyltransferases involved in cell wall biogenesis BN6_RS18565 Metabolism of a number of sulfonylurea herbicides BN6_RS18640 Serine proteinase with preferred activity for amino acids with aromatic side groups at the P1' side of the scissible bond BN6_RS18815 ABC-type antimicrobial peptide transport system, permease component BN6_RS18820 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS18830 Signal transduction histidine kinase BN6_RS18850 Signal transduction histidine kinase,glucose-6-phosphate specific BN6_RS18855 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS18860 Cytochrome P450 BN6_RS18870 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS18875 Permeases of the major facilitator superfamily BN6_RS18885 Non-ribosomal peptide synthetase modules and related proteins BN6_RS18895 Uncharacterized protein conserved in bacteria BN6_RS18900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS18905 Aromatic ring hydroxylase BN6_RS18910 Uncharacterized protein conserved in bacteria BN6_RS18915 Predicted O-methyltransferase BN6_RS18925 Cytochrome P450 BN6_RS18935 Cytochrome P450 BN6_RS18940 Pyruvate/2-oxoglutarate dehydrogenase complex,dihydrolipoamide acyltransferase (E2) component, and related enzymes BN6_RS18945 Pyruvate/2-oxoglutarate dehydrogenase complex,dehydrogenase (E1) component, eukaryotic type, beta subunit BN6_RS18950 Pyruvate/2-oxoglutarate dehydrogenase complex,dehydrogenase (E1) component, eukaryotic type, alpha subunit BN6_RS18955 Glutamyl-tRNA reductase BN6_RS18960 Chorismate mutase BN6_RS18970 Choline dehydrogenase and related flavoproteins BN6_RS18985 Cytochrome P450 BN6_RS18990 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB BN6_RS19015 Polyketide synthase modules and related proteins BN6_RS19020 Predicted thioesterase BN6_RS19030 dTDP-D-glucose 4,6-dehydratase BN6_RS19035 Transcriptional regulator BN6_RS19045 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases BN6_RS19050 Uncharacterized protein conserved in bacteria BN6_RS19250 Possible transporter that might be responsible for the adsorption of amidase substrates or release of their hydrolysis products BN6_RS19350 Involved in the degradation of long-chain fatty acids BN6_RS19375 Probable taurine catabolism dioxygenase BN6_RS19395 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS19640 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases BN6_RS19835 DNA-binding HTH domain-containing proteins BN6_RS19840 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS49675 Polyketide synthase modules and related proteins BN6_RS45820 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS19855 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS19860 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS19865 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS19870 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS19880 ATP-dependent transcriptional regulator BN6_RS19885 AraC-type DNA-binding domain-containing proteins BN6_RS46805 Predicted membrane protein BN6_RS19895 Predicted membrane protein BN6_RS19900 Glycosyltransferases involved in cell wall biogenesis BN6_RS19945 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases BN6_RS19950 Threonine dehydrogenase and related Zn-dependent dehydrogenases BN6_RS19955 Uncharacterized protein, putative amidase BN6_RS19970 Glycosyltransferase BN6_RS19980 GTP cyclohydrolase II BN6_RS19985 F0F1-type ATP synthase, subunit a BN6_RS19990 Coenzyme F390 synthetase BN6_RS19995 Histone acetyltransferase HPA2 and related acetyltransferases BN6_RS20000 DNA-binding transcriptional activator of the SARP family BN6_RS20010 Lantibiotic modifying enzyme BN6_RS20015 ABC-type multidrug transport system, ATPase and permease components BN6_RS20025 SAM-dependent methyltransferases BN6_RS20085 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP BN6_RS20135 ABC-type cobalt transport system, permease component CbiQ and related transporters BN6_RS20145 GMP synthase - Glutamine amidotransferase domain BN6_RS20165 Aqualysin I is a thermophilic alkaline serine protease BN6_RS20320 Not yet known BN6_RS20355 FOG: FHA domain BN6_RS20525 2-polyprenyl-6-methoxyphenol hydroxylase BN6_RS20550 Sugar diacid utilization regulator BN6_RS20720 Removes the amino-terminal methionine from nascent proteins BN6_RS20860 Glycosyltransferases involved in cell wall biogenesis BN6_RS20880 Transcriptional regulator BN6_RS21090 Hydrolyzes the ceramides into sphingosine and free fatty acid at an optimal pH of 8-9 BN6_RS21385 HD-GYP domain BN6_RS21480 Serine/threonine protein kinase BN6_RS21485 Permeases of the major facilitator superfamily BN6_RS21495 Thioredoxin reductase BN6_RS21510 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS21525 Predicted transcriptional regulators BN6_RS21530 Uncharacterized protein conserved in bacteria BN6_RS21550 Methylase involved in ubiquinone/menaquinone biosynthesis BN6_RS21555 Uncharacterized conserved protein BN6_RS21560 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS21565 Dihydrofolate reductase BN6_RS21650 Transcriptional regulator BN6_RS47975 Subtilisin-like serine proteases BN6_RS21820 Cytochrome P450 BN6_RS22050 Superfamily II DNA helicase BN6_RS22055 Tryptophanyl-tRNA synthetase BN6_RS22060 Cyclopropane fatty acid synthase and related methyltransferases BN6_RS22065 Uncharacterized protein conserved in bacteria BN6_RS22080 Uncharacterized protein conserved in bacteria BN6_RS22090 Predicted iron-dependent peroxidase BN6_RS22095 Nitrous oxidase accessory protein BN6_RS22115 Predicted Zn-dependent protease BN6_RS22120 Fibronectin type 3 domain-containing protein BN6_RS22125 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS22130 ABC-type Fe3+-siderophore transport system,permease component BN6_RS22135 ABC-type Fe3+-siderophore transport system,permease component BN6_RS22140 ABC-type Fe3+-hydroxamate transport system,periplasmic component BN6_RS47450 Fe-S oxidoreductase BN6_RS22180 Permeases of the major facilitator superfamily BN6_RS22195 Polyketide synthase modules and related proteins BN6_RS22200 Polyketide synthase modules and related proteins BN6_RS22210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS22215 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS22220 ABC-type multidrug transport system, ATPase and permease components BN6_RS22235 SAM-dependent methyltransferases BN6_RS22240 ABC-type uncharacterized transport system,duplicated ATPase component BN6_RS22245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components BN6_RS22260 Dehydrogenases (flavoproteins) BN6_RS22265 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS22270 Acyl carrier protein BN6_RS22280 Non-ribosomal peptide synthetase modules and related proteins BN6_RS22295 Non-ribosomal peptide synthetase modules and related proteins BN6_RS22310 Cytochrome P450 BN6_RS22320 ABC-type multidrug transport system, permease component BN6_RS22335 3-hydroxy-3-methylglutaryl CoA synthase BN6_RS22340 Acyl carrier protein BN6_RS22365 3-hydroxy-3-methylglutaryl CoA synthase BN6_RS22375 Dioxygenases related to 2-nitropropane dioxygenase BN6_RS22385 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS22390 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases BN6_RS22405 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS22460 Septum formation inhibitor BN6_RS22480 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS22495 Uncharacterized protein, possibly involved in glyoxylate utilization BN6_RS22530 Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane BN6_RS22545 This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though,unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system BN6_RS22675 Catalyzes the ortho-cleavage of the aromatic ring of hydroxyquinol BN6_RS22715 predicted lipase BN6_RS22720 Glycosidases BN6_RS22780 Predicted GTPase BN6_RS22790 Uncharacterized distant relative of homeotic protein bithoraxoid BN6_RS22795 Signal transduction histidine kinase BN6_RS22800 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS22830 Subtilisin-like serine proteases BN6_RS22835 Cytochrome P450 BN6_RS22845 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases BN6_RS22855 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS22860 Polyketide synthase modules and related proteins BN6_RS22865 Polyketide synthase modules and related proteins BN6_RS22870 4-aminobutyrate aminotransferase and related aminotransferases BN6_RS42240 DNA-binding transcriptional activator of the SARP family BN6_RS22890 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS22895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components BN6_RS22900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components BN6_RS22905 ABC-type dipeptide transport system,periplasmic component BN6_RS22915 Predicted ester cyclase BN6_RS22930 Polyketide synthase modules and related proteins BN6_RS49715 Polyketide synthase modules and related proteins BN6_RS22935 Polyketide synthase modules and related proteins BN6_RS22960 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) BN6_RS22965 Permeases of the major facilitator superfamily BN6_RS42260 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) BN6_RS22990 Topoisomerase IB BN6_RS23000 Predicted acetyltransferase BN6_RS23020 Transcriptional regulator BN6_RS23025 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS23040 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS23045 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis BN6_RS23050 Cytochrome P450 BN6_RS23055 FOG: WD40 repeat BN6_RS23065 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS23070 Non-ribosomal peptide synthetase modules and related proteins BN6_RS23075 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS23080 Cytochrome P450 BN6_RS42265 O-Glycosyl hydrolase BN6_RS42270 Cyclopropane fatty acid synthase and related methyltransferases BN6_RS23105 Protease subunit of ATP-dependent Clp proteases BN6_RS23110 Protease subunit of ATP-dependent Clp proteases BN6_RS23115 Predicted transcriptional regulators BN6_RS49020 Monoamine oxidase BN6_RS49025 Monoamine oxidase BN6_RS23130 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase BN6_RS23160 Non-ribosomal peptide synthetase modules and related proteins BN6_RS23165 Permeases of the major facilitator superfamily BN6_RS23180 Polyketide synthase modules and related proteins BN6_RS23185 Non-ribosomal peptide synthetase modules and related proteins BN6_RS23190 Uncharacterized protein conserved in bacteria BN6_RS23195 Transcriptional regulator BN6_RS23200 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS23205 Uncharacterized protein potentially involved in peptidoglycan biosynthesis BN6_RS23210 Beta-glucosidase-related glycosidases BN6_RS23300 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS23305 Aerobic-type carbon monoxide dehydrogenase,small subunit, CoxS/CutS homolog BN6_RS23310 Aerobic-type carbon monoxide dehydrogenase,middle subunit, CoxM/CutM homolog BN6_RS23315 Aerobic-type carbon monoxide dehydrogenase,large subunit, CoxL/CutL homolog BN6_RS23320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS23325 Glycosyltransferase BN6_RS23360 Leucine-rich repeat (LRR) protein BN6_RS48030 Polyketide synthase modules and related proteins BN6_RS23375 Polyketide synthase modules and related proteins BN6_RS23385 Biotin carboxylase BN6_RS48035 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS42295 Response regulator containing CheY-like receiver and SARP domains BN6_RS23415 Predicted transcriptional regulators BN6_RS23420 4-aminobutyrate aminotransferase and related aminotransferases BN6_RS23425 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family BN6_RS23440 Acyl-CoA dehydrogenases BN6_RS23445 Cytochrome P450 BN6_RS23450 NAD-dependent aldehyde dehydrogenases BN6_RS23465 Putative ketosteroid isomerase BN6_RS23470 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS23475 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS23480 7-keto-8-aminopelargonate synthetase and related enzymes BN6_RS23510 FOG: TPR repeat BN6_RS23760 Esterase/lipase BN6_RS23785 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS23795 Methionine synthase II (cobalamin-independent) BN6_RS23800 Ribonucleotide reductase, alpha subunit BN6_RS23805 Ribonucleotide reductase, beta subunit BN6_RS23810 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS23845 Positive regulator required for energy stress activation of the sigma-B transcription factor. Could be required for rsbP phosphatase activity BN6_RS23895 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP BN6_RS23930 Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than trpRS. Increases the solubility of the nitric oxide synthase oxygenase (nos), as well as its affinity for substrate L-arginine and its nitric-oxide synthase activity. The complex between trpS2 and nos catalyzes the regioselective nitration of tryptophan at the 4-position BN6_RS23940 predicted nucleoside-diphosphate-sugar epimerases BN6_RS23950 Catalyzes the reduction of N-ethylmaleimide (NEM) to N- ethylsuccinimide BN6_RS24045 Hydrolyzes the cellular pool of D-Ala-D-Ala dipeptides. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor BN6_RS24285 Glycosyltransferase BN6_RS24310 Not known, probably involved in the catabolism of octane and guaiacol. It displays a weak activity in the O-dealkylation of 7-ethoxycoumarin BN6_RS24315 Involved in 6-O-carbamoylation of Nod-factors BN6_RS24325 Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine BN6_RS24415 Nucleoside-diphosphate-sugar epimerases BN6_RS24425 Glycosyltransferases involved in cell wall biogenesis BN6_RS24430 ADP-heptose:LPS heptosyltransferase BN6_RS24450 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase BN6_RS24460 Glycosyltransferase BN6_RS24465 Glycosyltransferase BN6_RS24470 ADP-heptose:LPS heptosyltransferase BN6_RS24490 Predicted glycosyltransferases BN6_RS24555 Glycosyltransferase BN6_RS24590 Phytoene dehydrogenase and related proteins BN6_RS24595 Geranylgeranyl pyrophosphate synthase BN6_RS24600 Phytoene/squalene synthetase BN6_RS24605 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit BN6_RS24615 Methylase involved in ubiquinone/menaquinone biosynthesis BN6_RS24730 Threonine dehydrogenase and related Zn-dependent dehydrogenases BN6_RS24740 Cytochrome P450 BN6_RS24745 3-oxoacyl-[acyl-carrier-protein] synthase III BN6_RS24750 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS24760 Cytochrome P450 BN6_RS24785 Fructose-2,6-bisphosphatase BN6_RS24795 Anaerobic dehydrogenases, typically selenocysteine-containing BN6_RS24800 Sterol desaturase BN6_RS24805 AraC-type DNA-binding domain-containing proteins BN6_RS24815 ABC-type multidrug transport system, ATPase and permease components BN6_RS24820 Beta-lactamase class C and other penicillin binding proteins BN6_RS24830 Lysine 2,3-aminomutase BN6_RS24835 Non-ribosomal peptide synthetase modules and related proteins BN6_RS43025 Non-ribosomal peptide synthetase modules and related proteins BN6_RS24845 Lysine/ornithine N-monooxygenase BN6_RS24855 Mannose-6-phosphate isomerase BN6_RS24860 Glycine/D-amino acid oxidases (deaminating) BN6_RS24870 Predicted acyl-CoA transferases/carnitine dehydratase BN6_RS24875 Glycine/D-amino acid oxidases (deaminating) BN6_RS24880 Uncharacterized Fe-S protein BN6_RS24925 Not known, probably involved in the catabolism of octane and guaiacol. It displays a weak activity in the O-dealkylation of 7-ethoxycoumarin BN6_RS25200 ABC-type sugar transport systems, permease components BN6_RS25205 ABC-type sugar transport system BN6_RS25410 Fucose permease BN6_RS25415 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases BN6_RS25420 Predicted phosphatase/phosphohexomutase BN6_RS25425 Pentose-5-phosphate-3-epimerase BN6_RS25430 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis BN6_RS25435 NADPH:quinone reductase and related Zn-dependent oxidoreductases BN6_RS25440 Threonine dehydrogenase and related Zn-dependent dehydrogenases BN6_RS25445 3-dehydroquinate synthetase BN6_RS25450 Transcriptional regulator/sugar kinase BN6_RS25460 Transcriptional regulator/sugar kinase BN6_RS25465 ADP-ribose pyrophosphatase BN6_RS25475 Transcriptional regulator BN6_RS25480 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS25485 Transcriptional regulator BN6_RS25490 Putative translation initiation inhibitor, yjgF family BN6_RS25495 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS25500 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS25505 Predicted deacylase BN6_RS25510 ABC-type dipeptide transport system,periplasmic component BN6_RS25515 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components BN6_RS25525 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS25530 Aspartate/tyrosine/aromatic aminotransferase BN6_RS25545 Transcriptional regulators BN6_RS25560 Predicted Zn-dependent proteases and their inactivated homologs BN6_RS25570 Predicted dehydrogenases and related proteins BN6_RS25585 Threonine dehydrogenase and related Zn-dependent dehydrogenases BN6_RS25590 Predicted integral membrane protein BN6_RS25595 ABC-type bacteriocin/lantibiotic exporters,contain an N-terminal double-glycine peptidase domain BN6_RS25605 ABC-type bacteriocin/lantibiotic exporters,contain an N-terminal double-glycine peptidase domain BN6_RS25610 membrane-fusion protein BN6_RS25630 Non-ribosomal peptide synthetase modules and related proteins BN6_RS25635 FOG: PAS/PAC domain BN6_RS25645 Cytochrome P450 BN6_RS25655 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases BN6_RS25680 Uncharacterized conserved protein BN6_RS25700 Uncharacterized conserved protein BN6_RS25715 Heme/copper-type cytochrome/quinol oxidases,subunit 1 BN6_RS25720 Predicted Zn-dependent hydrolases of the beta-lactamase fold BN6_RS25725 Mn2+ and Fe2+ transporters of the NRAMP family BN6_RS25760 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS25765 NADPH:quinone reductase and related Zn-dependent oxidoreductases BN6_RS25770 Imidazoleglycerol-phosphate synthase BN6_RS25775 Predicted NAD/FAD-binding protein BN6_RS25800 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) BN6_RS26065 Subtilisin-like serine proteases BN6_RS26070 ABC-type multidrug transport system, ATPase and permease components BN6_RS26075 Asparagine synthase (glutamine-hydrolyzing) BN6_RS26090 Transcriptional regulators BN6_RS26095 Cytosine deaminase and related metal-dependent hydrolases BN6_RS26120 Predicted metal-dependent hydrolase with the TIM-barrel fold BN6_RS42425 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family BN6_RS26145 ABC-type multidrug transport system, permease component BN6_RS26150 ATPase components of various ABC-type transport systems, contain duplicated ATPase BN6_RS26160 Cytochrome P450 BN6_RS26165 Nitroreductase BN6_RS46955 Nitroreductase BN6_RS26190 Uncharacterized conserved protein BN6_RS26215 Predicted transcriptional regulator BN6_RS26220 Uncharacterized protein conserved in bacteria BN6_RS26225 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases BN6_RS26230 Transcriptional regulator BN6_RS26235 Uncharacterized protein conserved in bacteria BN6_RS26345 Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism BN6_RS26350 Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene,encoding a putative copper-transfer gene, probably by altering copper metabolism BN6_RS26425 Asparagine synthase (glutamine-hydrolyzing) BN6_RS26435 Transcriptional regulator/sugar kinase BN6_RS26445 Predicted flavoprotein BN6_RS26450 Cytochrome P450 BN6_RS26460 4-aminobutyrate aminotransferase and related aminotransferases BN6_RS26465 SAM-dependent methyltransferases BN6_RS26475 Predicted ester cyclase BN6_RS26480 Uncharacterized NAD(FAD)-dependent dehydrogenases BN6_RS26485 Predicted transcriptional regulators BN6_RS26490 Permeases of the major facilitator superfamily BN6_RS26495 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) BN6_RS26500 Biotin carboxylase BN6_RS26505 Biotin carboxylase BN6_RS26515 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS26520 3-oxoacyl-(acyl-carrier-protein) synthase BN6_RS26530 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS26540 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) BN6_RS26545 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) BN6_RS26595 Permeases of the major facilitator superfamily BN6_RS26605 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS26610 Acyl-CoA dehydrogenases BN6_RS26615 Acyl-CoA dehydrogenases BN6_RS26620 Predicted thioesterase involved in non-ribosomal peptide biosynthesis BN6_RS26625 Non-ribosomal peptide synthetase modules and related proteins BN6_RS26630 Cytochrome P450 BN6_RS26640 Cytochrome P450 BN6_RS26645 Cytochrome P450 BN6_RS26650 Selenocysteine lyase BN6_RS26655 Predicted flavoprotein involved in K+ transport BN6_RS26660 Thioredoxin reductase BN6_RS26665 Predicted transcriptional regulators BN6_RS26820 Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system BN6_RS27155 Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts a phosphate group from devS (dosS) and from dosT BN6_RS27185 FOG: CBS domain BN6_RS27190 Universal stress protein UspA and related nucleotide-binding proteins BN6_RS27195 Acyl-CoA synthetase (NDP forming) BN6_RS27200 Universal stress protein UspA and related nucleotide-binding proteins BN6_RS27205 Universal stress protein UspA and related nucleotide-binding proteins BN6_RS27220 Predicted ATP-dependent endonuclease of the OLD family BN6_RS49775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain BN6_RS49135 Lantibiotic modifying enzyme BN6_RS48125 Integrase BN6_RS48130 Integrase BN6_RS27265 Non-ribosomal peptide synthetase modules and related proteins BN6_RS27270 Polyketide synthase modules and related proteins BN6_RS27275 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases BN6_RS27280 Non-ribosomal peptide synthetase modules and related proteins BN6_RS27295 Translation elongation factor EF-1alpha (GTPase) BN6_RS27305 Permeases of the major facilitator superfamily BN6_RS27310 Predicted aminopeptidases BN6_RS27320 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases BN6_RS27325 Acetylglutamate semialdehyde dehydrogenase BN6_RS27340 Deoxyxylulose-5-phosphate synthase BN6_RS27350 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis BN6_RS27355 Cytochrome P450 BN6_RS27360 Acyl-CoA dehydrogenases BN6_RS27365 Acyl-CoA dehydrogenases BN6_RS27370 Non-ribosomal peptide synthetase modules and related proteins BN6_RS27385 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases BN6_RS27390 Non-ribosomal peptide synthetase modules and related proteins BN6_RS27400 Non-ribosomal peptide synthetase modules and related proteins BN6_RS46995 Predicted enzyme related to lactoylglutathione lyase BN6_RS27415 Transposase and inactivated derivatives BN6_RS27835 dTDP-D-glucose 4,6-dehydratase BN6_RS28085 A leucine-specific metalloprotease that plays a role in controlling the amount of leupeptin during colony development. Degrades leupeptin into three components,acetyl-leucine, leucine and argininal BN6_RS28170 Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA BN6_RS28190 Sortase and related acyltransferases BN6_RS28195 AraC-type DNA-binding domain-containing proteins BN6_RS28210 Aromatic ring hydroxylase BN6_RS28215 dTDP-glucose pyrophosphorylase BN6_RS28220 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II BN6_RS28225 Histidine ammonia-lyase BN6_RS28230 Methylase involved in ubiquinone/menaquinone biosynthesis BN6_RS28240 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28245 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28250 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28255 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28260 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28265 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28270 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28275 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28280 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28285 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS28295 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) BN6_RS28300 Predicted membrane protein BN6_RS28305 Uncharacterized conserved protein BN6_RS28320 Threonine synthase BN6_RS28335 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis BN6_RS28350 Predicted dehydrogenases and related proteins BN6_RS28355 Predicted methyltransferasee (contains TPR repeat) BN6_RS28360 Adenylylsulfate kinase and related kinases BN6_RS28370 Predicted membrane protein BN6_RS28375 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS28380 Predicted integral membrane protein BN6_RS28625 membrane protein involved in the export of O-antigen and teichoic acid BN6_RS28630 Glycosyltransferase BN6_RS28635 Glycosyltransferase BN6_RS28650 Glycosyltransferases involved in cell wall biogenesis BN6_RS28690 Responsible for tylosin resistance, and is proposed to be a subunit of a multicomponent export system for the energy- dependent efflux of tylosin BN6_RS28730 Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon BN6_RS28865 Lignostilbene-alpha,beta-dioxygenase BN6_RS28965 Predicted drug exporters of the RND superfamily BN6_RS28970 Transcriptional regulators BN6_RS28975 Transcriptional regulator BN6_RS29010 Beta-lactamase class C and other penicillin binding proteins BN6_RS29015 Protein-tyrosine-phosphatase BN6_RS29020 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) BN6_RS29025 Protein-tyrosine-phosphatase BN6_RS29030 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS29035 H+/gluconate symporter and related permeases BN6_RS29050 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS29055 Subtilisin-like serine proteases BN6_RS29065 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS29070 Putative translation factor (SUA5) BN6_RS29085 DNA-binding transcriptional activator of the SARP family BN6_RS29095 Exochitinase that generates exclusively chitobiose from chitotetraose, chitohexaose, and colloidal high-molecular mass chitin BN6_RS29200 Involved in glutamate biosynthesis and plays a major role in the primary ammonium ions assimilation in seedling roots. May be involved in the reutilization of glutamine in developing organs. Plays a role in the development of tillers BN6_RS29245 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases BN6_RS29250 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases BN6_RS29255 Geranylgeranyl pyrophosphate synthase BN6_RS29260 Penicillin tolerance protein BN6_RS29265 Deoxyxylulose-5-phosphate synthase BN6_RS29270 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis BN6_RS29325 Glycosyltransferases involved in cell wall biogenesis BN6_RS29390 Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system BN6_RS29590 Subtilisin-like serine proteases BN6_RS29660 NAD-dependent aldehyde dehydrogenases BN6_RS29745 Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide,maltooligosyl trehalose (alpha- maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation BN6_RS29860 Cell division protein FtsI/penicillin-binding protein 2 BN6_RS29925 Subtilisin-like serine proteases BN6_RS29930 dGTP triphosphohydrolase BN6_RS29960 FOG: EAL domain BN6_RS29965 Uncharacterized conserved protein BN6_RS29980 Predicted metal-sulfur cluster biosynthetic enzyme BN6_RS29985 NifU-like protein, involved in Fe-S cluster formation BN6_RS29990 Selenocysteine lyase BN6_RS29995 ABC-type transport system involved in Fe-S cluster assembly, ATPase component BN6_RS30000 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit BN6_RS30005 ABC-type transport system involved in Fe-S cluster assembly, permease component BN6_RS30010 ABC-type transport system involved in Fe-S cluster assembly, permease component BN6_RS30030 Glycosyltransferase BN6_RS30330 ATP-dependent transcriptional regulator BN6_RS30340 May act as RNA methyltransferase BN6_RS30385 DNA-directed RNA polymerase, subunit K/omega BN6_RS30475 3-dehydroquinate synthetase BN6_RS46135 May be involved in active puromycin efflux energized by a proton-dependent electrochemical gradient. In addition, it could be implicated in secreting N-acetylpuromycin, the last intermediate of the puromycin biosynthesis pathway, to the environment BN6_RS30765 Catalyzes the cyclization of 2-amino-4,5-dihydroxy-6- one-heptanoic acid-7-phosphate to yield 3-amino-4-hydroxybenzoic acid (3,4-AHBA) BN6_RS30770 Catalyzes aldol condensation between L-aspartate-4- semialdehyde (ASA) and dihydroxyacetone phosphate (DHAP), to form 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate BN6_RS30785 FOG: TPR repeat BN6_RS30875 Catalyzes the reduction of N-ethylmaleimide (NEM) to N- ethylsuccinimide BN6_RS31045 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) BN6_RS31065 Short-chain alcohol dehydrogenase of unknown specificity BN6_RS31105 Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin BN6_RS31110 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP BN6_RS31245 DNA-directed RNA polymerase specialized sigma subunit BN6_RS31480 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) BN6_RS31620 May play a role in septum formation BN6_RS31635 May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer BN6_RS31785 Ornithine/acetylornithine aminotransferase BN6_RS31870 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins BN6_RS32025 Dihydrodipicolinate synthase/N-acetylneuraminate lyase BN6_RS32135 Predicted integral membrane protein BN6_RS32325 In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity BN6_RS32340 Component of the high-affinity branched-chain amino acid transport system BN6_RS32365 Member of the two-component regulatory system pdtaR/pdtaS BN6_RS32385 Transcriptional regulator BN6_RS32405 Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive BN6_RS32445 Transcriptional regulator BN6_RS32455 Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase BN6_RS32655 Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine BN6_RS32720 Interconversion of serine and glycine BN6_RS32800 Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose BN6_RS32885 Glutamate decarboxylase and related PLP-dependent proteins BN6_RS32905 Uncharacterized conserved protein BN6_RS32930 Glycosyl transferases, related to UDP-glucuronosyltransferase BN6_RS32935 Putative translation initiation inhibitor, yjgF family BN6_RS32940 Predicted transcriptional regulators BN6_RS32945 NADPH-dependent glutamate synthase beta chain and related oxidoreductases BN6_RS32950 Glutamate synthase domain 1 BN6_RS32990 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate BN6_RS33135 Catalyzes the oxidation of L-aspartate to iminoaspartate BN6_RS33195 Not known, probably involved in the catabolism of octane and guaiacol. It displays a weak activity in the O-dealkylation of 7-ethoxycoumarin BN6_RS33320 UDP-N-acetylmuramate-alanine ligase BN6_RS33330 Bacterial cell division membrane protein BN6_RS33355 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase BN6_RS33370 Cell division protein FtsI/penicillin-binding protein 2 BN6_RS33470 May function as a proton-driven pyrimidine uptake system BN6_RS33540 Dihydrodipicolinate synthase/N-acetylneuraminate lyase BN6_RS33725 uncharacterized conserved protein BN6_RS33770 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS33865 ATP:corrinoid adenosyltransferase BN6_RS34045 Methionine aminopeptidase BN6_RS34050 Predicted nucleic acid-binding protein,contains PIN domain BN6_RS34065 Predicted acetyltransferase BN6_RS34070 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis BN6_RS34075 Predicted membrane-associated Zn-dependent proteases 1 BN6_RS34180 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome BN6_RS34300 Involved in the uptake of ammonia (Probable) BN6_RS34555 8 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) BN6_RS34565 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic function in B.subtilis as it is necessary for growth on glucose, but is not required for sporulation BN6_RS34695 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate BN6_RS34700 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate BN6_RS35070 Glycosyltransferase BN6_RS35140 Glucan phosphorylase BN6_RS35150 Could be involved in glycogen catabolism BN6_RS35155 Catalyzes the conversion of maltose into alpha,alpha- trehalose by transglucosylation BN6_RS35255 Phosphomannose isomerase BN6_RS35285 Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts a phosphate group from devS (dosS) and from dosT BN6_RS35465 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain BN6_RS35475 Required for the assimilation of methanol and ethanol BN6_RS35555 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase BN6_RS35600 Required for the transposition of the insertion element (Potential) BN6_RS35735 Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter BN6_RS35860 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase BN6_RS48265 ABC-type amino acid transport system, permease component BN6_RS36135 ABC-type amino acid transport/signal transduction systems BN6_RS36160 Cyclopropane fatty acid synthase BN6_RS36220 Enzyme is most active on medium length p-nitrophenyl esters (with C8 to C12 acyl chains) BN6_RS36285 Transforms O-acetylhomoserine into homocysteine BN6_RS36340 May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer BN6_RS36490 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes BN6_RS36585 Histone acetyltransferase HPA2 BN6_RS36630 uncharacterized conserved protein BN6_RS36715 Predicted amidophosphoribosyltransferases BN6_RS36730 Member of the two-component regulatory system mtrA/mtrB BN6_RS36785 Phosphomannose isomerase BN6_RS36800 Phosphomannomutase BN6_RS36830 Uncharacterized conserved protein BN6_RS36850 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) BN6_RS36860 Predicted glycosyltransferases BN6_RS36870 Glycosyltransferase BN6_RS36875 Glycosyltransferase BN6_RS36895 membrane carboxypeptidase (penicillin-binding protein) BN6_RS37030 Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) BN6_RS37065 Involved in the catabolism of branched amino acids such as leucine (Probable) BN6_RS37165 May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ),5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH BN6_RS37170 Key enzyme in the regulation of glycerol uptake and metabolism BN6_RS37210 Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis. It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA BN6_RS37580 Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases BN6_RS37610 Essential for pSAM2 replication BN6_RS37980 Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence BN6_RS38050 predicted ATPase BN6_RS38135 Phosphomannomutase BN6_RS38225 Glycosyltransferase BN6_RS38250 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates BN6_RS38415 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis BN6_RS38470 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates BN6_RS38475 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates BN6_RS38490 ABC-type transport system involved in resistance to organic solvents BN6_RS38500 ABC-type transport system involved in resistance to organic solvents BN6_RS38505 ABC-type transport system involved in resistance to organic solvents BN6_RS38530 Not known, could be involved in the transport of ribonucleotides BN6_RS38645 dTDP-glucose pyrophosphorylase BN6_RS38755 Essential for pSAM2 replication BN6_RS38890 Glycosyltransferase BN6_RS38910 May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation BN6_RS38930 May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation BN6_RS39120 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps BN6_RS39230 Probably forms part of a two-component regulatory system regX3/senX3 BN6_RS39235 Part of the two-component regulatory system senX3/regX3. Phosphorylates regX3 under conditions of phosphate limitation. Probably does not itself sense phosphate concentrations, which may be relayed to senX3 by the pstSCAB phosphate transporter system BN6_RS39705 Activates the transcription of the glnA gene BN6_RS39730 May be a sulfotransferase involved in the formation of thiosulfate BN6_RS39855 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog BN6_RS39870 Glutamine phosphoribosylpyrophosphate amidotransferase BN6_RS39925 Hydrolyzes chitosan and chitooligosaccharides with retention of anomeric configuration. Has no beta-mannosidase activity BN6_RS39970 This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities BN6_RS40030 Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system BN6_RS40075 Stereospecifically catalyzes the interconversion of L- allo-threonine and glycine BN6_RS40180 Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane BN6_RS40185 Adenylosuccinate synthase BN6_RS40660 Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system BN6_RS40920 Acts to efflux copper or a copper complex. It is possible that yfmO could contribute to copper resistance BN6_RS40950 membrane carboxypeptidase (penicillin-binding protein) BN6_RS40955 Predicted integral membrane protein BN6_RS40990 Predicted integral membrane protein BN6_RS41160 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA BN6_RS41170 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) BN6_RS49430 Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis BN6_RS49435 Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane