-- dump date 20140620_042533 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1179773000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1179773000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000003 Walker A motif; other site 1179773000004 ATP binding site [chemical binding]; other site 1179773000005 Walker B motif; other site 1179773000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1179773000007 DnaA box-binding interface [nucleotide binding]; other site 1179773000008 DNA polymerase III subunit beta; Validated; Region: PRK07761 1179773000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1179773000010 putative DNA binding surface [nucleotide binding]; other site 1179773000011 dimer interface [polypeptide binding]; other site 1179773000012 beta-clamp/clamp loader binding surface; other site 1179773000013 beta-clamp/translesion DNA polymerase binding surface; other site 1179773000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1179773000016 recombination protein F; Reviewed; Region: recF; PRK00064 1179773000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1179773000018 Walker A/P-loop; other site 1179773000019 ATP binding site [chemical binding]; other site 1179773000020 Q-loop/lid; other site 1179773000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773000022 ABC transporter signature motif; other site 1179773000023 Walker B; other site 1179773000024 D-loop; other site 1179773000025 H-loop/switch region; other site 1179773000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1179773000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1179773000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773000029 ATP binding site [chemical binding]; other site 1179773000030 Mg2+ binding site [ion binding]; other site 1179773000031 G-X-G motif; other site 1179773000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1179773000033 anchoring element; other site 1179773000034 dimer interface [polypeptide binding]; other site 1179773000035 ATP binding site [chemical binding]; other site 1179773000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1179773000037 active site 1179773000038 putative metal-binding site [ion binding]; other site 1179773000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1179773000040 DNA gyrase subunit A; Validated; Region: PRK05560 1179773000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1179773000042 CAP-like domain; other site 1179773000043 active site 1179773000044 primary dimer interface [polypeptide binding]; other site 1179773000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1179773000052 RibD C-terminal domain; Region: RibD_C; cl17279 1179773000053 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1179773000054 Predicted membrane protein [Function unknown]; Region: COG2259 1179773000055 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1179773000056 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1179773000057 active site 1179773000058 Rhomboid family; Region: Rhomboid; pfam01694 1179773000059 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1179773000060 putative septation inhibitor protein; Reviewed; Region: PRK00159 1179773000061 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1179773000062 active site 1179773000063 catalytic site [active] 1179773000064 ferredoxin-NADP+ reductase; Region: PLN02852 1179773000065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773000066 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1179773000067 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1179773000068 glutamine binding [chemical binding]; other site 1179773000069 catalytic triad [active] 1179773000070 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773000071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773000072 active site 1179773000073 ATP binding site [chemical binding]; other site 1179773000074 substrate binding site [chemical binding]; other site 1179773000075 activation loop (A-loop); other site 1179773000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773000079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773000080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773000081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773000082 active site 1179773000083 ATP binding site [chemical binding]; other site 1179773000084 substrate binding site [chemical binding]; other site 1179773000085 activation loop (A-loop); other site 1179773000086 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1179773000087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1179773000088 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1179773000089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1179773000090 active site 1179773000091 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1179773000092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1179773000093 phosphopeptide binding site; other site 1179773000094 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1179773000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1179773000096 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1179773000097 phosphopeptide binding site; other site 1179773000098 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1179773000099 RNA binding site [nucleotide binding]; other site 1179773000100 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1179773000101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773000102 NAD(P) binding site [chemical binding]; other site 1179773000103 putative active site [active] 1179773000104 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1179773000105 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1179773000106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1179773000107 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1179773000108 dimer interface [polypeptide binding]; other site 1179773000109 active site 1179773000110 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773000111 substrate binding site [chemical binding]; other site 1179773000112 catalytic residue [active] 1179773000113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773000114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773000115 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1179773000116 beta-galactosidase; Region: BGL; TIGR03356 1179773000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000118 putative substrate translocation pore; other site 1179773000119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773000120 classical (c) SDRs; Region: SDR_c; cd05233 1179773000121 NAD(P) binding site [chemical binding]; other site 1179773000122 active site 1179773000123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773000124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773000125 salt bridge; other site 1179773000126 non-specific DNA binding site [nucleotide binding]; other site 1179773000127 sequence-specific DNA binding site [nucleotide binding]; other site 1179773000128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773000130 TPR motif; other site 1179773000131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000132 binding surface 1179773000133 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773000134 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773000135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773000136 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773000137 NAD(P) binding site [chemical binding]; other site 1179773000138 active site 1179773000139 NACHT domain; Region: NACHT; pfam05729 1179773000140 Copper resistance protein D; Region: CopD; pfam05425 1179773000141 CopC domain; Region: CopC; pfam04234 1179773000142 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1179773000143 BCCT family transporter; Region: BCCT; pfam02028 1179773000144 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1179773000145 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1179773000146 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1179773000147 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1179773000148 NAD binding site [chemical binding]; other site 1179773000149 homodimer interface [polypeptide binding]; other site 1179773000150 homotetramer interface [polypeptide binding]; other site 1179773000151 active site 1179773000152 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1179773000153 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1179773000154 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1179773000155 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1179773000156 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1179773000157 Histidine kinase; Region: HisKA_3; pfam07730 1179773000158 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773000159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773000160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773000161 active site 1179773000162 phosphorylation site [posttranslational modification] 1179773000163 intermolecular recognition site; other site 1179773000164 dimerization interface [polypeptide binding]; other site 1179773000165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773000166 DNA binding residues [nucleotide binding] 1179773000167 dimerization interface [polypeptide binding]; other site 1179773000168 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1179773000169 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1179773000170 NADP-binding site; other site 1179773000171 homotetramer interface [polypeptide binding]; other site 1179773000172 substrate binding site [chemical binding]; other site 1179773000173 homodimer interface [polypeptide binding]; other site 1179773000174 active site 1179773000175 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1179773000176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773000177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773000178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773000179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773000180 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773000181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773000182 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1179773000183 Short C-terminal domain; Region: SHOCT; pfam09851 1179773000184 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1179773000185 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1179773000186 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773000187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773000188 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773000189 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1179773000190 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1179773000191 putative DNA binding site [nucleotide binding]; other site 1179773000192 catalytic residue [active] 1179773000193 putative H2TH interface [polypeptide binding]; other site 1179773000194 putative catalytic residues [active] 1179773000195 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1179773000196 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1179773000197 Histidine kinase; Region: His_kinase; pfam06580 1179773000198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773000199 ATP binding site [chemical binding]; other site 1179773000200 Mg2+ binding site [ion binding]; other site 1179773000201 G-X-G motif; other site 1179773000202 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1179773000203 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1179773000204 tandem repeat interface [polypeptide binding]; other site 1179773000205 oligomer interface [polypeptide binding]; other site 1179773000206 active site residues [active] 1179773000207 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1179773000208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773000209 active site 1179773000210 phosphorylation site [posttranslational modification] 1179773000211 intermolecular recognition site; other site 1179773000212 dimerization interface [polypeptide binding]; other site 1179773000213 LytTr DNA-binding domain; Region: LytTR; smart00850 1179773000214 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1179773000215 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1179773000216 Na binding site [ion binding]; other site 1179773000217 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773000218 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773000219 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773000220 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773000221 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773000222 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1179773000223 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1179773000224 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1179773000225 Na binding site [ion binding]; other site 1179773000226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773000227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773000228 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1179773000229 active site residue [active] 1179773000230 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1179773000231 Vta1 like; Region: DUF605; pfam04652 1179773000232 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773000233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773000234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773000235 DNA binding residues [nucleotide binding] 1179773000236 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773000237 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1179773000238 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1179773000239 active site 1179773000240 catalytic site [active] 1179773000241 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773000242 Cytochrome P450; Region: p450; cl12078 1179773000243 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1179773000244 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1179773000245 putative active site [active] 1179773000246 catalytic site [active] 1179773000247 putative metal binding site [ion binding]; other site 1179773000248 SEC-C motif; Region: SEC-C; pfam02810 1179773000249 Protein of unknown function (DUF952); Region: DUF952; cl01393 1179773000250 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773000251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773000252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773000253 DNA binding residues [nucleotide binding] 1179773000254 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1179773000255 Ferritin-like domain; Region: Ferritin; pfam00210 1179773000256 ferroxidase diiron center [ion binding]; other site 1179773000257 arginine deiminase; Provisional; Region: PRK01388 1179773000258 Caspase domain; Region: Peptidase_C14; pfam00656 1179773000259 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1179773000260 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1179773000261 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1179773000262 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1179773000263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773000264 CAAX protease self-immunity; Region: Abi; pfam02517 1179773000265 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1179773000266 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1179773000267 metal ion-dependent adhesion site (MIDAS); other site 1179773000268 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773000269 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1179773000270 SWIM zinc finger; Region: SWIM; pfam04434 1179773000271 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1179773000272 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1179773000273 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1179773000274 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773000275 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773000276 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773000277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773000278 Predicted membrane protein [Function unknown]; Region: COG2119 1179773000279 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1179773000280 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1179773000281 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1179773000282 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1179773000283 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1179773000284 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1179773000285 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1179773000286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773000287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773000288 Walker A/P-loop; other site 1179773000289 ATP binding site [chemical binding]; other site 1179773000290 ABC transporter; Region: ABC_tran; pfam00005 1179773000291 Q-loop/lid; other site 1179773000292 ABC transporter signature motif; other site 1179773000293 Walker B; other site 1179773000294 D-loop; other site 1179773000295 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1179773000296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773000297 Walker A/P-loop; other site 1179773000298 ATP binding site [chemical binding]; other site 1179773000299 Q-loop/lid; other site 1179773000300 ABC transporter signature motif; other site 1179773000301 Walker B; other site 1179773000302 D-loop; other site 1179773000303 H-loop/switch region; other site 1179773000304 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773000305 GAF domain; Region: GAF_3; pfam13492 1179773000306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773000307 Histidine kinase; Region: HisKA_3; pfam07730 1179773000308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773000309 ATP binding site [chemical binding]; other site 1179773000310 Mg2+ binding site [ion binding]; other site 1179773000311 G-X-G motif; other site 1179773000312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773000313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773000314 active site 1179773000315 phosphorylation site [posttranslational modification] 1179773000316 intermolecular recognition site; other site 1179773000317 dimerization interface [polypeptide binding]; other site 1179773000318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773000319 DNA binding residues [nucleotide binding] 1179773000320 dimerization interface [polypeptide binding]; other site 1179773000321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773000322 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1179773000323 Coenzyme A binding pocket [chemical binding]; other site 1179773000324 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1179773000325 prephenate dehydratase; Provisional; Region: PRK11898 1179773000326 Prephenate dehydratase; Region: PDT; pfam00800 1179773000327 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1179773000328 putative L-Phe binding site [chemical binding]; other site 1179773000329 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1179773000330 catalytic core [active] 1179773000331 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1179773000332 Septum formation; Region: Septum_form; pfam13845 1179773000333 Septum formation; Region: Septum_form; pfam13845 1179773000334 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1179773000335 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1179773000336 seryl-tRNA synthetase; Provisional; Region: PRK05431 1179773000337 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1179773000338 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1179773000339 dimer interface [polypeptide binding]; other site 1179773000340 active site 1179773000341 motif 1; other site 1179773000342 motif 2; other site 1179773000343 motif 3; other site 1179773000344 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773000345 putative trimer interface [polypeptide binding]; other site 1179773000346 putative CoA binding site [chemical binding]; other site 1179773000347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1179773000348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773000349 NAD(P) binding site [chemical binding]; other site 1179773000350 active site 1179773000351 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773000352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773000353 acyl-activating enzyme (AAE) consensus motif; other site 1179773000354 AMP binding site [chemical binding]; other site 1179773000355 active site 1179773000356 CoA binding site [chemical binding]; other site 1179773000357 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1179773000358 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773000359 NAD(P) binding site [chemical binding]; other site 1179773000360 catalytic residues [active] 1179773000361 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773000362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773000363 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773000364 YCII-related domain; Region: YCII; cl00999 1179773000365 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773000366 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1179773000367 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1179773000368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1179773000369 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773000370 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773000371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773000372 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1179773000373 active site 1179773000374 motif I; other site 1179773000375 motif II; other site 1179773000376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773000377 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773000378 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773000379 inhibitor-cofactor binding pocket; inhibition site 1179773000380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773000381 catalytic residue [active] 1179773000382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773000383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773000384 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1179773000385 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1179773000386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1179773000387 active site 1179773000388 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1179773000389 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1179773000390 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1179773000391 Ligand binding site; other site 1179773000392 Putative Catalytic site; other site 1179773000393 DXD motif; other site 1179773000394 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1179773000395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773000396 UDP-galactopyranose mutase; Region: GLF; pfam03275 1179773000397 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1179773000398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773000399 active site 1179773000400 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773000401 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773000402 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1179773000403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773000404 active site 1179773000405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773000406 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1179773000407 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1179773000408 Walker A/P-loop; other site 1179773000409 ATP binding site [chemical binding]; other site 1179773000410 Q-loop/lid; other site 1179773000411 ABC transporter signature motif; other site 1179773000412 Walker B; other site 1179773000413 D-loop; other site 1179773000414 H-loop/switch region; other site 1179773000415 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1179773000416 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773000417 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1179773000418 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1179773000419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773000420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773000421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773000422 catalytic residue [active] 1179773000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773000424 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1179773000425 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1179773000426 NAD(P) binding site [chemical binding]; other site 1179773000427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773000428 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773000429 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773000430 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1179773000431 PA/protease or protease-like domain interface [polypeptide binding]; other site 1179773000432 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1179773000433 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773000434 active site 1179773000435 metal binding site [ion binding]; metal-binding site 1179773000436 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773000437 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1179773000438 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1179773000439 putative active site [active] 1179773000440 putative metal binding site [ion binding]; other site 1179773000441 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1179773000442 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773000443 MarR family; Region: MarR_2; cl17246 1179773000444 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1179773000445 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1179773000446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1179773000447 hypothetical protein; Provisional; Region: PRK10621 1179773000448 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1179773000449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773000450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773000451 homodimer interface [polypeptide binding]; other site 1179773000452 catalytic residue [active] 1179773000453 Dienelactone hydrolase family; Region: DLH; pfam01738 1179773000454 EspG family; Region: ESX-1_EspG; pfam14011 1179773000455 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1179773000456 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1179773000457 acyl-activating enzyme (AAE) consensus motif; other site 1179773000458 putative AMP binding site [chemical binding]; other site 1179773000459 putative active site [active] 1179773000460 putative CoA binding site [chemical binding]; other site 1179773000461 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773000462 DNA binding site [nucleotide binding] 1179773000463 Int/Topo IB signature motif; other site 1179773000464 active site 1179773000465 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773000466 Helix-turn-helix domain; Region: HTH_38; pfam13936 1179773000467 Integrase core domain; Region: rve; pfam00665 1179773000468 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1179773000469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773000470 TPR motif; other site 1179773000471 binding surface 1179773000472 YCII-related domain; Region: YCII; cl00999 1179773000473 RibD C-terminal domain; Region: RibD_C; cl17279 1179773000474 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1179773000475 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773000476 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773000477 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773000478 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773000479 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773000480 calcium binding site 2 [ion binding]; other site 1179773000481 active site 1179773000482 catalytic triad [active] 1179773000483 calcium binding site 1 [ion binding]; other site 1179773000484 D-mannose binding lectin; Region: B_lectin; pfam01453 1179773000485 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1179773000486 mannose binding site [chemical binding]; other site 1179773000487 dimerization interface [polypeptide binding]; other site 1179773000488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773000489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773000490 non-specific DNA binding site [nucleotide binding]; other site 1179773000491 salt bridge; other site 1179773000492 sequence-specific DNA binding site [nucleotide binding]; other site 1179773000493 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773000494 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1179773000495 putative NAD(P) binding site [chemical binding]; other site 1179773000496 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773000497 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773000498 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1179773000499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773000500 NAD(P) binding site [chemical binding]; other site 1179773000501 active site 1179773000502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773000503 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1179773000504 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773000505 cofactor binding site; other site 1179773000506 DNA binding site [nucleotide binding] 1179773000507 substrate interaction site [chemical binding]; other site 1179773000508 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773000509 TQXA domain; Region: TQXA_dom; TIGR03934 1179773000510 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1179773000511 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1179773000512 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1179773000513 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773000514 dimer interface [polypeptide binding]; other site 1179773000515 active site 1179773000516 prephenate dehydrogenase; Validated; Region: PRK06545 1179773000517 prephenate dehydrogenase; Validated; Region: PRK08507 1179773000518 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1179773000519 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1179773000520 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1179773000521 metal binding site [ion binding]; metal-binding site 1179773000522 dimer interface [polypeptide binding]; other site 1179773000523 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1179773000524 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1179773000525 nucleoside/Zn binding site; other site 1179773000526 dimer interface [polypeptide binding]; other site 1179773000527 catalytic motif [active] 1179773000528 CsbD-like; Region: CsbD; pfam05532 1179773000529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773000530 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773000531 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773000533 S-adenosylmethionine binding site [chemical binding]; other site 1179773000534 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1179773000535 generic binding surface I; other site 1179773000536 generic binding surface II; other site 1179773000537 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1179773000538 putative catalytic site [active] 1179773000539 putative metal binding site [ion binding]; other site 1179773000540 putative phosphate binding site [ion binding]; other site 1179773000541 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773000542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773000543 non-specific DNA binding site [nucleotide binding]; other site 1179773000544 salt bridge; other site 1179773000545 sequence-specific DNA binding site [nucleotide binding]; other site 1179773000546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773000547 non-specific DNA binding site [nucleotide binding]; other site 1179773000548 salt bridge; other site 1179773000549 sequence-specific DNA binding site [nucleotide binding]; other site 1179773000550 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1179773000551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000552 Walker A motif; other site 1179773000553 ATP binding site [chemical binding]; other site 1179773000554 Walker B motif; other site 1179773000555 arginine finger; other site 1179773000556 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1179773000557 hypothetical protein; Validated; Region: PRK00153 1179773000558 recombination protein RecR; Reviewed; Region: recR; PRK00076 1179773000559 RecR protein; Region: RecR; pfam02132 1179773000560 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1179773000561 putative active site [active] 1179773000562 putative metal-binding site [ion binding]; other site 1179773000563 tetramer interface [polypeptide binding]; other site 1179773000564 hypothetical protein; Provisional; Region: PRK06547 1179773000565 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773000566 DNA binding site [nucleotide binding] 1179773000567 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773000568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000569 NB-ARC domain; Region: NB-ARC; pfam00931 1179773000570 AAA domain; Region: AAA_14; pfam13173 1179773000571 Walker A motif; other site 1179773000572 ATP binding site [chemical binding]; other site 1179773000573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773000575 binding surface 1179773000576 TPR motif; other site 1179773000577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000578 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773000580 binding surface 1179773000581 TPR motif; other site 1179773000582 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773000584 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1179773000585 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773000586 peptide binding site [polypeptide binding]; other site 1179773000587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773000588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773000589 dimer interface [polypeptide binding]; other site 1179773000590 conserved gate region; other site 1179773000591 putative PBP binding loops; other site 1179773000592 ABC-ATPase subunit interface; other site 1179773000593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773000594 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1179773000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773000596 ABC-ATPase subunit interface; other site 1179773000597 putative PBP binding loops; other site 1179773000598 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773000599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773000600 Walker A/P-loop; other site 1179773000601 ATP binding site [chemical binding]; other site 1179773000602 Q-loop/lid; other site 1179773000603 ABC transporter signature motif; other site 1179773000604 Walker B; other site 1179773000605 D-loop; other site 1179773000606 H-loop/switch region; other site 1179773000607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773000608 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1179773000609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773000610 Walker A/P-loop; other site 1179773000611 ATP binding site [chemical binding]; other site 1179773000612 Q-loop/lid; other site 1179773000613 ABC transporter signature motif; other site 1179773000614 Walker B; other site 1179773000615 D-loop; other site 1179773000616 H-loop/switch region; other site 1179773000617 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773000618 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773000619 TIGR03086 family protein; Region: TIGR03086 1179773000620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773000621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773000622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1179773000623 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1179773000624 2-isopropylmalate synthase; Validated; Region: PRK03739 1179773000625 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1179773000626 active site 1179773000627 catalytic residues [active] 1179773000628 metal binding site [ion binding]; metal-binding site 1179773000629 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1179773000630 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1179773000631 putative FMN binding site [chemical binding]; other site 1179773000632 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1179773000633 aspartate kinase; Reviewed; Region: PRK06635 1179773000634 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1179773000635 putative nucleotide binding site [chemical binding]; other site 1179773000636 putative catalytic residues [active] 1179773000637 putative Mg ion binding site [ion binding]; other site 1179773000638 putative aspartate binding site [chemical binding]; other site 1179773000639 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1179773000640 putative allosteric regulatory site; other site 1179773000641 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1179773000642 putative allosteric regulatory residue; other site 1179773000643 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1179773000644 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1179773000645 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1179773000646 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1179773000647 N- and C-terminal domain interface [polypeptide binding]; other site 1179773000648 active site 1179773000649 catalytic site [active] 1179773000650 metal binding site [ion binding]; metal-binding site 1179773000651 carbohydrate binding site [chemical binding]; other site 1179773000652 ATP binding site [chemical binding]; other site 1179773000653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773000654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000655 putative substrate translocation pore; other site 1179773000656 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1179773000657 metal binding site 2 [ion binding]; metal-binding site 1179773000658 putative DNA binding helix; other site 1179773000659 metal binding site 1 [ion binding]; metal-binding site 1179773000660 dimer interface [polypeptide binding]; other site 1179773000661 structural Zn2+ binding site [ion binding]; other site 1179773000662 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1179773000663 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1179773000664 tetramer interface [polypeptide binding]; other site 1179773000665 heme binding pocket [chemical binding]; other site 1179773000666 NADPH binding site [chemical binding]; other site 1179773000667 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773000668 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773000669 substrate binding pocket [chemical binding]; other site 1179773000670 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773000671 Predicted flavoprotein [General function prediction only]; Region: COG0431 1179773000672 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773000673 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1179773000674 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1179773000675 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1179773000676 dimerization interface [polypeptide binding]; other site 1179773000677 DPS ferroxidase diiron center [ion binding]; other site 1179773000678 ion pore; other site 1179773000679 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773000680 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773000681 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773000682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773000683 S-adenosylmethionine binding site [chemical binding]; other site 1179773000684 MarR family; Region: MarR_2; pfam12802 1179773000685 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773000686 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1179773000687 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773000688 putative active site [active] 1179773000689 putative metal binding site [ion binding]; other site 1179773000690 Yqey-like protein; Region: YqeY; cl17540 1179773000691 AAA domain; Region: AAA_33; pfam13671 1179773000692 AAA domain; Region: AAA_17; pfam13207 1179773000693 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1179773000694 Transglycosylase; Region: Transgly; pfam00912 1179773000695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1179773000696 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773000697 Transcription factor WhiB; Region: Whib; pfam02467 1179773000698 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1179773000699 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1179773000700 P loop; other site 1179773000701 Nucleotide binding site [chemical binding]; other site 1179773000702 DTAP/Switch II; other site 1179773000703 Switch I; other site 1179773000704 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773000705 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1179773000706 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1179773000707 DTAP/Switch II; other site 1179773000708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773000709 non-specific DNA binding site [nucleotide binding]; other site 1179773000710 salt bridge; other site 1179773000711 sequence-specific DNA binding site [nucleotide binding]; other site 1179773000712 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773000713 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1179773000714 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1179773000715 homotrimer interaction site [polypeptide binding]; other site 1179773000716 putative active site [active] 1179773000717 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773000718 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773000719 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773000720 nudix motif; other site 1179773000721 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1179773000722 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773000723 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773000724 dimerization interface [polypeptide binding]; other site 1179773000725 putative DNA binding site [nucleotide binding]; other site 1179773000726 putative Zn2+ binding site [ion binding]; other site 1179773000727 DNA polymerase III subunit beta; Validated; Region: PRK07761 1179773000728 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1179773000729 putative DNA binding surface [nucleotide binding]; other site 1179773000730 dimer interface [polypeptide binding]; other site 1179773000731 beta-clamp/clamp loader binding surface; other site 1179773000732 beta-clamp/translesion DNA polymerase binding surface; other site 1179773000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773000735 putative substrate translocation pore; other site 1179773000736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773000737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773000738 ligand binding site [chemical binding]; other site 1179773000739 flexible hinge region; other site 1179773000740 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1179773000741 putative switch regulator; other site 1179773000742 non-specific DNA interactions [nucleotide binding]; other site 1179773000743 DNA binding site [nucleotide binding] 1179773000744 sequence specific DNA binding site [nucleotide binding]; other site 1179773000745 putative cAMP binding site [chemical binding]; other site 1179773000746 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1179773000747 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1179773000748 minor groove reading motif; other site 1179773000749 helix-hairpin-helix signature motif; other site 1179773000750 substrate binding pocket [chemical binding]; other site 1179773000751 active site 1179773000752 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1179773000753 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1179773000754 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773000755 catalytic residues [active] 1179773000756 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1179773000757 putative active site [active] 1179773000758 putative CoA binding site [chemical binding]; other site 1179773000759 nudix motif; other site 1179773000760 metal binding site [ion binding]; metal-binding site 1179773000761 Colicin V production protein; Region: Colicin_V; pfam02674 1179773000762 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1179773000763 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773000764 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773000765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773000766 S-adenosylmethionine binding site [chemical binding]; other site 1179773000767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773000768 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1179773000769 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1179773000770 acetyl-CoA synthetase; Provisional; Region: PRK00174 1179773000771 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1179773000772 active site 1179773000773 CoA binding site [chemical binding]; other site 1179773000774 acyl-activating enzyme (AAE) consensus motif; other site 1179773000775 AMP binding site [chemical binding]; other site 1179773000776 acetate binding site [chemical binding]; other site 1179773000777 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773000778 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773000779 Fic family protein [Function unknown]; Region: COG3177 1179773000780 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773000781 kynureninase; Region: kynureninase; TIGR01814 1179773000782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773000783 catalytic residue [active] 1179773000784 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1179773000785 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773000786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773000787 putative DNA binding site [nucleotide binding]; other site 1179773000788 putative Zn2+ binding site [ion binding]; other site 1179773000789 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773000790 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1179773000791 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1179773000792 putative active site [active] 1179773000793 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1179773000794 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1179773000795 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1179773000796 putative active site [active] 1179773000797 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773000798 Beta-lactamase; Region: Beta-lactamase; cl17358 1179773000799 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1179773000800 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773000801 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1179773000802 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1179773000803 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1179773000804 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1179773000805 Type II/IV secretion system protein; Region: T2SE; pfam00437 1179773000806 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1179773000807 ATP binding site [chemical binding]; other site 1179773000808 Walker A motif; other site 1179773000809 hexamer interface [polypeptide binding]; other site 1179773000810 Walker B motif; other site 1179773000811 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1179773000812 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1179773000813 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1179773000814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773000815 ATP binding site [chemical binding]; other site 1179773000816 putative Mg++ binding site [ion binding]; other site 1179773000817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773000818 nucleotide binding region [chemical binding]; other site 1179773000819 ATP-binding site [chemical binding]; other site 1179773000820 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1179773000821 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1179773000822 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1179773000823 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1179773000824 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1179773000825 active site 1179773000826 interdomain interaction site; other site 1179773000827 putative metal-binding site [ion binding]; other site 1179773000828 nucleotide binding site [chemical binding]; other site 1179773000829 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1179773000830 domain I; other site 1179773000831 phosphate binding site [ion binding]; other site 1179773000832 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1179773000833 domain II; other site 1179773000834 domain III; other site 1179773000835 nucleotide binding site [chemical binding]; other site 1179773000836 DNA binding groove [nucleotide binding] 1179773000837 catalytic site [active] 1179773000838 domain IV; other site 1179773000839 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1179773000840 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1179773000841 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1179773000842 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773000843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000845 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773000846 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1179773000847 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1179773000848 HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]; Region: HRD1; COG5243 1179773000849 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773000850 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773000851 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1179773000852 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1179773000853 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1179773000854 23S rRNA interface [nucleotide binding]; other site 1179773000855 L7/L12 interface [polypeptide binding]; other site 1179773000856 putative thiostrepton binding site; other site 1179773000857 L25 interface [polypeptide binding]; other site 1179773000858 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773000859 CoenzymeA binding site [chemical binding]; other site 1179773000860 subunit interaction site [polypeptide binding]; other site 1179773000861 PHB binding site; other site 1179773000862 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773000863 MarR family; Region: MarR; pfam01047 1179773000864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000865 putative substrate translocation pore; other site 1179773000866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773000868 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1179773000869 dimer interface [polypeptide binding]; other site 1179773000870 substrate binding site [chemical binding]; other site 1179773000871 metal binding sites [ion binding]; metal-binding site 1179773000872 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1179773000873 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1179773000874 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1179773000875 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1179773000876 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1179773000877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1179773000878 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1179773000879 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773000880 metal ion-dependent adhesion site (MIDAS); other site 1179773000881 FtsH Extracellular; Region: FtsH_ext; pfam06480 1179773000882 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1179773000883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000884 Walker A motif; other site 1179773000885 ATP binding site [chemical binding]; other site 1179773000886 Walker B motif; other site 1179773000887 arginine finger; other site 1179773000888 Peptidase family M41; Region: Peptidase_M41; pfam01434 1179773000889 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1179773000890 active site 1179773000891 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1179773000892 dihydropteroate synthase; Region: DHPS; TIGR01496 1179773000893 substrate binding pocket [chemical binding]; other site 1179773000894 dimer interface [polypeptide binding]; other site 1179773000895 inhibitor binding site; inhibition site 1179773000896 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1179773000897 homooctamer interface [polypeptide binding]; other site 1179773000898 active site 1179773000899 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1179773000900 catalytic center binding site [active] 1179773000901 ATP binding site [chemical binding]; other site 1179773000902 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773000903 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1179773000904 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1179773000905 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1179773000906 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 1179773000907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773000908 MarR family; Region: MarR_2; pfam12802 1179773000909 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1179773000910 Protease prsW family; Region: PrsW-protease; pfam13367 1179773000911 Rossmann-like domain; Region: Rossmann-like; pfam10727 1179773000912 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1179773000913 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1179773000914 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1179773000915 active site 1179773000916 ATP-binding site [chemical binding]; other site 1179773000917 pantoate-binding site; other site 1179773000918 HXXH motif; other site 1179773000919 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1179773000920 tetramerization interface [polypeptide binding]; other site 1179773000921 active site 1179773000922 pantothenate kinase; Reviewed; Region: PRK13318 1179773000923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773000924 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1179773000925 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1179773000926 dimer interface [polypeptide binding]; other site 1179773000927 putative anticodon binding site; other site 1179773000928 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773000929 motif 1; other site 1179773000930 dimer interface [polypeptide binding]; other site 1179773000931 active site 1179773000932 motif 2; other site 1179773000933 motif 3; other site 1179773000934 Lsr2; Region: Lsr2; pfam11774 1179773000935 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1179773000936 Clp protease ATP binding subunit; Region: clpC; CHL00095 1179773000937 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773000938 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773000939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000940 Walker A motif; other site 1179773000941 ATP binding site [chemical binding]; other site 1179773000942 Walker B motif; other site 1179773000943 arginine finger; other site 1179773000944 UvrB/uvrC motif; Region: UVR; pfam02151 1179773000945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773000946 Walker A motif; other site 1179773000947 ATP binding site [chemical binding]; other site 1179773000948 Walker B motif; other site 1179773000949 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1179773000950 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1179773000951 putative substrate binding pocket [chemical binding]; other site 1179773000952 AC domain interface; other site 1179773000953 catalytic triad [active] 1179773000954 AB domain interface; other site 1179773000955 interchain disulfide; other site 1179773000956 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1179773000957 putative catalytic site [active] 1179773000958 putative phosphate binding site [ion binding]; other site 1179773000959 putative metal binding site [ion binding]; other site 1179773000960 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1179773000961 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1179773000962 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1179773000963 Zn binding site [ion binding]; other site 1179773000964 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773000965 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773000966 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1179773000967 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1179773000968 endonuclease III; Region: ENDO3c; smart00478 1179773000969 minor groove reading motif; other site 1179773000970 helix-hairpin-helix signature motif; other site 1179773000971 substrate binding pocket [chemical binding]; other site 1179773000972 active site 1179773000973 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1179773000974 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1179773000975 active site clefts [active] 1179773000976 zinc binding site [ion binding]; other site 1179773000977 dimer interface [polypeptide binding]; other site 1179773000978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773000979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773000980 DNA binding site [nucleotide binding] 1179773000981 domain linker motif; other site 1179773000982 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1179773000983 putative dimerization interface [polypeptide binding]; other site 1179773000984 putative ligand binding site [chemical binding]; other site 1179773000985 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773000986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773000987 DNA binding site [nucleotide binding] 1179773000988 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773000989 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1179773000990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773000991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773000992 dimer interface [polypeptide binding]; other site 1179773000993 conserved gate region; other site 1179773000994 putative PBP binding loops; other site 1179773000995 ABC-ATPase subunit interface; other site 1179773000996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773000997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773000998 dimer interface [polypeptide binding]; other site 1179773000999 conserved gate region; other site 1179773001000 putative PBP binding loops; other site 1179773001001 ABC-ATPase subunit interface; other site 1179773001002 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1179773001003 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1179773001004 Walker A/P-loop; other site 1179773001005 ATP binding site [chemical binding]; other site 1179773001006 Q-loop/lid; other site 1179773001007 ABC transporter signature motif; other site 1179773001008 Walker B; other site 1179773001009 D-loop; other site 1179773001010 H-loop/switch region; other site 1179773001011 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773001012 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1179773001013 intersubunit interface [polypeptide binding]; other site 1179773001014 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1179773001015 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1179773001016 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1179773001017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773001018 putative PBP binding regions; other site 1179773001019 ABC-ATPase subunit interface; other site 1179773001020 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1179773001021 UTRA domain; Region: UTRA; pfam07702 1179773001022 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1179773001023 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1179773001024 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1179773001025 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773001026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001027 putative PBP binding loops; other site 1179773001028 dimer interface [polypeptide binding]; other site 1179773001029 ABC-ATPase subunit interface; other site 1179773001030 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773001031 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773001032 Walker A/P-loop; other site 1179773001033 ATP binding site [chemical binding]; other site 1179773001034 Q-loop/lid; other site 1179773001035 ABC transporter signature motif; other site 1179773001036 Walker B; other site 1179773001037 D-loop; other site 1179773001038 H-loop/switch region; other site 1179773001039 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1179773001040 L-aspartate oxidase; Provisional; Region: PRK06175 1179773001041 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1179773001042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773001043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773001044 metal binding site [ion binding]; metal-binding site 1179773001045 active site 1179773001046 I-site; other site 1179773001047 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773001049 putative substrate translocation pore; other site 1179773001050 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1179773001051 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1179773001052 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1179773001053 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1179773001054 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1179773001055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773001056 active site 1179773001057 HIGH motif; other site 1179773001058 nucleotide binding site [chemical binding]; other site 1179773001059 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1179773001060 KMSKS motif; other site 1179773001061 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1179773001062 tRNA binding surface [nucleotide binding]; other site 1179773001063 anticodon binding site; other site 1179773001064 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1179773001065 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1179773001066 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773001067 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1179773001068 homotrimer interaction site [polypeptide binding]; other site 1179773001069 zinc binding site [ion binding]; other site 1179773001070 CDP-binding sites; other site 1179773001071 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1179773001072 substrate binding site; other site 1179773001073 dimer interface; other site 1179773001074 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1179773001075 Protein of unknown function (DUF461); Region: DUF461; cl01071 1179773001076 DNA repair protein RadA; Provisional; Region: PRK11823 1179773001077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1179773001078 Walker A motif; other site 1179773001079 ATP binding site [chemical binding]; other site 1179773001080 Walker B motif; other site 1179773001081 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1179773001082 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1179773001083 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1179773001084 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1179773001085 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1179773001086 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1179773001087 active site 1179773001088 homotetramer interface [polypeptide binding]; other site 1179773001089 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1179773001090 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1179773001091 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1179773001092 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1179773001093 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773001094 metal ion-dependent adhesion site (MIDAS); other site 1179773001095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773001096 HAMP domain; Region: HAMP; pfam00672 1179773001097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773001098 dimer interface [polypeptide binding]; other site 1179773001099 phosphorylation site [posttranslational modification] 1179773001100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773001101 ATP binding site [chemical binding]; other site 1179773001102 Mg2+ binding site [ion binding]; other site 1179773001103 G-X-G motif; other site 1179773001104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773001106 active site 1179773001107 phosphorylation site [posttranslational modification] 1179773001108 intermolecular recognition site; other site 1179773001109 dimerization interface [polypeptide binding]; other site 1179773001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773001111 DNA binding site [nucleotide binding] 1179773001112 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1179773001113 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1179773001114 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1179773001115 FAD binding pocket [chemical binding]; other site 1179773001116 FAD binding motif [chemical binding]; other site 1179773001117 phosphate binding motif [ion binding]; other site 1179773001118 beta-alpha-beta structure motif; other site 1179773001119 NAD binding pocket [chemical binding]; other site 1179773001120 FMN-binding domain; Region: FMN_bind; cl01081 1179773001121 ApbE family; Region: ApbE; pfam02424 1179773001122 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1179773001123 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773001124 DNA binding site [nucleotide binding] 1179773001125 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773001126 NB-ARC domain; Region: NB-ARC; pfam00931 1179773001127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773001128 TPR motif; other site 1179773001129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773001130 binding surface 1179773001131 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1179773001132 active site 1179773001133 catalytic triad [active] 1179773001134 oxyanion hole [active] 1179773001135 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1179773001136 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1179773001137 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1179773001138 NAD binding site [chemical binding]; other site 1179773001139 sugar binding site [chemical binding]; other site 1179773001140 divalent metal binding site [ion binding]; other site 1179773001141 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1179773001142 dimer interface [polypeptide binding]; other site 1179773001143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773001144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001145 dimer interface [polypeptide binding]; other site 1179773001146 conserved gate region; other site 1179773001147 putative PBP binding loops; other site 1179773001148 ABC-ATPase subunit interface; other site 1179773001149 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1179773001150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001151 dimer interface [polypeptide binding]; other site 1179773001152 conserved gate region; other site 1179773001153 putative PBP binding loops; other site 1179773001154 ABC-ATPase subunit interface; other site 1179773001155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773001156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773001157 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773001158 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773001159 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773001160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773001161 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1179773001162 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1179773001163 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1179773001164 putative active site [active] 1179773001165 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1179773001166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773001167 active site 1179773001168 catalytic tetrad [active] 1179773001169 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1179773001170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001171 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773001172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773001173 DNA-binding site [nucleotide binding]; DNA binding site 1179773001174 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1179773001175 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1179773001176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773001177 active site 1179773001178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773001179 S-adenosylmethionine binding site [chemical binding]; other site 1179773001180 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773001181 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1179773001182 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1179773001183 dimer interface [polypeptide binding]; other site 1179773001184 active site 1179773001185 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1179773001186 dimer interface [polypeptide binding]; other site 1179773001187 active site 1179773001188 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773001189 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1179773001190 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773001191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001192 dimer interface [polypeptide binding]; other site 1179773001193 ABC-ATPase subunit interface; other site 1179773001194 putative PBP binding loops; other site 1179773001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001196 putative PBP binding loops; other site 1179773001197 dimer interface [polypeptide binding]; other site 1179773001198 ABC-ATPase subunit interface; other site 1179773001199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773001200 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773001201 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773001202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773001203 DNA-binding site [nucleotide binding]; DNA binding site 1179773001204 UTRA domain; Region: UTRA; pfam07702 1179773001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773001206 putative substrate translocation pore; other site 1179773001207 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1179773001208 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1179773001209 tetramer interface [polypeptide binding]; other site 1179773001210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773001211 catalytic residue [active] 1179773001212 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773001213 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1179773001214 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1179773001215 putative active site [active] 1179773001216 metal binding site [ion binding]; metal-binding site 1179773001217 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1179773001218 thiamine phosphate binding site [chemical binding]; other site 1179773001219 active site 1179773001220 pyrophosphate binding site [ion binding]; other site 1179773001221 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1179773001222 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1179773001223 thiS-thiF/thiG interaction site; other site 1179773001224 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1179773001225 ThiS interaction site; other site 1179773001226 putative active site [active] 1179773001227 tetramer interface [polypeptide binding]; other site 1179773001228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773001229 MarR family; Region: MarR; pfam01047 1179773001230 MarR family; Region: MarR_2; cl17246 1179773001231 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1179773001232 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1179773001233 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1179773001234 dimer interface [polypeptide binding]; other site 1179773001235 substrate binding site [chemical binding]; other site 1179773001236 ATP binding site [chemical binding]; other site 1179773001237 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1179773001238 ThiC-associated domain; Region: ThiC-associated; pfam13667 1179773001239 ThiC family; Region: ThiC; pfam01964 1179773001240 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1179773001241 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1179773001242 active site 1179773001243 catalytic residues [active] 1179773001244 metal binding site [ion binding]; metal-binding site 1179773001245 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1179773001246 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1179773001247 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1179773001248 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1179773001249 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1179773001250 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1179773001251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773001252 ATP binding site [chemical binding]; other site 1179773001253 Walker B motif; other site 1179773001254 arginine finger; other site 1179773001255 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1179773001256 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1179773001257 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1179773001258 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1179773001259 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1179773001260 dimer interface [polypeptide binding]; other site 1179773001261 putative functional site; other site 1179773001262 putative MPT binding site; other site 1179773001263 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1179773001264 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773001265 DNA-binding site [nucleotide binding]; DNA binding site 1179773001266 RNA-binding motif; other site 1179773001267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773001268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773001269 active site 1179773001270 ATP binding site [chemical binding]; other site 1179773001271 substrate binding site [chemical binding]; other site 1179773001272 activation loop (A-loop); other site 1179773001273 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1179773001274 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1179773001275 ring oligomerisation interface [polypeptide binding]; other site 1179773001276 ATP/Mg binding site [chemical binding]; other site 1179773001277 stacking interactions; other site 1179773001278 hinge regions; other site 1179773001279 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773001280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773001281 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1179773001282 CutC family; Region: CutC; cl01218 1179773001283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773001284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773001285 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1179773001286 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773001287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001288 dimer interface [polypeptide binding]; other site 1179773001289 conserved gate region; other site 1179773001290 putative PBP binding loops; other site 1179773001291 ABC-ATPase subunit interface; other site 1179773001292 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1179773001293 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1179773001294 active site 1179773001295 PspC domain; Region: PspC; pfam04024 1179773001296 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773001297 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1179773001298 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773001299 metal ion-dependent adhesion site (MIDAS); other site 1179773001300 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1179773001301 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1179773001302 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1179773001303 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1179773001304 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1179773001305 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1179773001306 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1179773001307 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1179773001308 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1179773001309 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1179773001310 putative hydrophobic ligand binding site [chemical binding]; other site 1179773001311 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1179773001312 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1179773001313 putative active site [active] 1179773001314 putative metal binding site [ion binding]; other site 1179773001315 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1179773001316 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1179773001317 active site 1179773001318 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1179773001319 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1179773001320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1179773001321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773001322 ATP binding site [chemical binding]; other site 1179773001323 putative Mg++ binding site [ion binding]; other site 1179773001324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773001325 nucleotide binding region [chemical binding]; other site 1179773001326 ATP-binding site [chemical binding]; other site 1179773001327 NMT1-like family; Region: NMT1_2; pfam13379 1179773001328 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1179773001329 Nitrate and nitrite sensing; Region: NIT; pfam08376 1179773001330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773001331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773001332 ATP binding site [chemical binding]; other site 1179773001333 Mg2+ binding site [ion binding]; other site 1179773001334 G-X-G motif; other site 1179773001335 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1179773001336 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773001337 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1179773001338 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1179773001339 G2 box; other site 1179773001340 Switch I region; other site 1179773001341 G3 box; other site 1179773001342 Switch II region; other site 1179773001343 GTP/Mg2+ binding site [chemical binding]; other site 1179773001344 G4 box; other site 1179773001345 G5 box; other site 1179773001346 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1179773001347 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1179773001348 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1179773001349 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1179773001350 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1179773001351 putative NAD(P) binding site [chemical binding]; other site 1179773001352 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1179773001353 trimer interface [polypeptide binding]; other site 1179773001354 dimer interface [polypeptide binding]; other site 1179773001355 putative active site [active] 1179773001356 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1179773001357 MPT binding site; other site 1179773001358 trimer interface [polypeptide binding]; other site 1179773001359 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1179773001360 MoaE homodimer interface [polypeptide binding]; other site 1179773001361 MoaD interaction [polypeptide binding]; other site 1179773001362 active site residues [active] 1179773001363 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1179773001364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773001365 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1179773001366 MoaE interaction surface [polypeptide binding]; other site 1179773001367 MoeB interaction surface [polypeptide binding]; other site 1179773001368 thiocarboxylated glycine; other site 1179773001369 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1179773001370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773001371 FeS/SAM binding site; other site 1179773001372 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1179773001373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773001374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773001375 putative DNA binding site [nucleotide binding]; other site 1179773001376 putative Zn2+ binding site [ion binding]; other site 1179773001377 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1179773001378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773001379 active site 1179773001380 motif I; other site 1179773001381 motif II; other site 1179773001382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773001383 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773001384 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773001385 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773001386 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1179773001387 active site 1179773001388 metal binding site [ion binding]; metal-binding site 1179773001389 hypothetical protein; Provisional; Region: PRK11770 1179773001390 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1179773001391 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1179773001392 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1179773001393 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1179773001394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001396 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1179773001397 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773001398 DNA-binding site [nucleotide binding]; DNA binding site 1179773001399 RNA-binding motif; other site 1179773001400 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1179773001401 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773001402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773001403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773001404 catalytic residue [active] 1179773001405 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773001406 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773001407 putative DNA binding site [nucleotide binding]; other site 1179773001408 putative Zn2+ binding site [ion binding]; other site 1179773001409 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773001410 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1179773001411 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1179773001412 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1179773001413 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1179773001414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773001415 MarR family; Region: MarR; pfam01047 1179773001416 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773001417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773001418 putative substrate translocation pore; other site 1179773001419 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1179773001420 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1179773001421 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1179773001422 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773001423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773001424 Walker A/P-loop; other site 1179773001425 ATP binding site [chemical binding]; other site 1179773001426 ABC transporter signature motif; other site 1179773001427 Walker B; other site 1179773001428 D-loop; other site 1179773001429 H-loop/switch region; other site 1179773001430 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773001431 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773001432 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1179773001433 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1179773001434 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1179773001435 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773001436 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773001437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773001438 Walker A/P-loop; other site 1179773001439 ATP binding site [chemical binding]; other site 1179773001440 Q-loop/lid; other site 1179773001441 ABC transporter signature motif; other site 1179773001442 Walker B; other site 1179773001443 D-loop; other site 1179773001444 H-loop/switch region; other site 1179773001445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773001446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773001447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773001448 Walker A/P-loop; other site 1179773001449 ATP binding site [chemical binding]; other site 1179773001450 Q-loop/lid; other site 1179773001451 ABC transporter signature motif; other site 1179773001452 Walker B; other site 1179773001453 D-loop; other site 1179773001454 H-loop/switch region; other site 1179773001455 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1179773001456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773001457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773001458 catalytic residue [active] 1179773001459 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773001460 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773001461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773001462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773001463 Walker A/P-loop; other site 1179773001464 ATP binding site [chemical binding]; other site 1179773001465 Q-loop/lid; other site 1179773001466 ABC transporter signature motif; other site 1179773001467 Walker B; other site 1179773001468 D-loop; other site 1179773001469 H-loop/switch region; other site 1179773001470 citrate synthase 2; Provisional; Region: PRK12350 1179773001471 Citrate synthase; Region: Citrate_synt; pfam00285 1179773001472 oxalacetate binding site [chemical binding]; other site 1179773001473 citrylCoA binding site [chemical binding]; other site 1179773001474 coenzyme A binding site [chemical binding]; other site 1179773001475 catalytic triad [active] 1179773001476 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773001477 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1179773001478 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1179773001479 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773001480 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1179773001481 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773001482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773001483 putative substrate translocation pore; other site 1179773001484 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773001485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001486 non-specific DNA binding site [nucleotide binding]; other site 1179773001487 salt bridge; other site 1179773001488 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001489 amino acid transporter; Region: 2A0306; TIGR00909 1179773001490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1179773001491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001493 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1179773001494 active site 1179773001495 catalytic residues [active] 1179773001496 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1179773001497 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1179773001498 active site 1179773001499 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773001500 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773001501 active site 1179773001502 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1179773001503 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773001504 putative substrate binding site [chemical binding]; other site 1179773001505 putative ATP binding site [chemical binding]; other site 1179773001506 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1179773001507 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1179773001508 dimer interface [polypeptide binding]; other site 1179773001509 active site 1179773001510 citrylCoA binding site [chemical binding]; other site 1179773001511 NADH binding [chemical binding]; other site 1179773001512 cationic pore residues; other site 1179773001513 oxalacetate/citrate binding site [chemical binding]; other site 1179773001514 coenzyme A binding site [chemical binding]; other site 1179773001515 catalytic triad [active] 1179773001516 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1179773001517 DNA photolyase; Region: DNA_photolyase; pfam00875 1179773001518 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1179773001519 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1179773001520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773001521 Walker A/P-loop; other site 1179773001522 ATP binding site [chemical binding]; other site 1179773001523 Q-loop/lid; other site 1179773001524 ABC transporter signature motif; other site 1179773001525 Walker B; other site 1179773001526 D-loop; other site 1179773001527 H-loop/switch region; other site 1179773001528 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1179773001529 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773001530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001531 non-specific DNA binding site [nucleotide binding]; other site 1179773001532 salt bridge; other site 1179773001533 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001534 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773001535 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773001536 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1179773001537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001539 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773001540 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773001541 cytosine deaminase; Provisional; Region: PRK05985 1179773001542 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1179773001543 active site 1179773001544 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1179773001545 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1179773001546 NAD(P) binding site [chemical binding]; other site 1179773001547 substrate binding site [chemical binding]; other site 1179773001548 dimer interface [polypeptide binding]; other site 1179773001549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773001550 Coenzyme A binding pocket [chemical binding]; other site 1179773001551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773001552 Coenzyme A binding pocket [chemical binding]; other site 1179773001553 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1179773001554 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773001555 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1179773001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773001557 NAD(P) binding site [chemical binding]; other site 1179773001558 active site 1179773001559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001560 non-specific DNA binding site [nucleotide binding]; other site 1179773001561 salt bridge; other site 1179773001562 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001563 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1179773001564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773001565 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773001566 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1179773001567 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1179773001568 putative active site pocket [active] 1179773001569 dimerization interface [polypeptide binding]; other site 1179773001570 putative catalytic residue [active] 1179773001571 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1179773001572 putative active site pocket [active] 1179773001573 dimerization interface [polypeptide binding]; other site 1179773001574 putative catalytic residue [active] 1179773001575 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773001576 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773001577 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773001578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773001579 NAD(P) binding site [chemical binding]; other site 1179773001580 active site 1179773001581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773001582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773001583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773001584 dimerization interface [polypeptide binding]; other site 1179773001585 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1179773001586 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1179773001587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773001588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773001589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773001590 dimerization interface [polypeptide binding]; other site 1179773001591 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1179773001592 G1 box; other site 1179773001593 GTP/Mg2+ binding site [chemical binding]; other site 1179773001594 G2 box; other site 1179773001595 Switch I region; other site 1179773001596 G3 box; other site 1179773001597 Switch II region; other site 1179773001598 G4 box; other site 1179773001599 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1179773001600 Dynamin family; Region: Dynamin_N; pfam00350 1179773001601 G1 box; other site 1179773001602 GTP/Mg2+ binding site [chemical binding]; other site 1179773001603 G2 box; other site 1179773001604 Switch I region; other site 1179773001605 G3 box; other site 1179773001606 Switch II region; other site 1179773001607 G4 box; other site 1179773001608 G5 box; other site 1179773001609 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773001610 nucleotide binding site [chemical binding]; other site 1179773001611 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773001612 SBD interface [polypeptide binding]; other site 1179773001613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773001614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773001615 DNA binding residues [nucleotide binding] 1179773001616 dimerization interface [polypeptide binding]; other site 1179773001617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001619 Carboxylesterase family; Region: COesterase; pfam00135 1179773001620 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773001621 substrate binding pocket [chemical binding]; other site 1179773001622 catalytic triad [active] 1179773001623 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 1179773001624 AAA ATPase domain; Region: AAA_16; pfam13191 1179773001625 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773001626 WD40 repeats; Region: WD40; smart00320 1179773001627 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773001628 structural tetrad; other site 1179773001629 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773001630 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773001631 structural tetrad; other site 1179773001632 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1179773001633 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1179773001634 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1179773001635 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1179773001636 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1179773001637 minor groove reading motif; other site 1179773001638 helix-hairpin-helix signature motif; other site 1179773001639 substrate binding pocket [chemical binding]; other site 1179773001640 active site 1179773001641 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1179773001642 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1179773001643 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1179773001644 DNA binding site [nucleotide binding] 1179773001645 active site 1179773001646 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1179773001647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773001648 putative DNA binding site [nucleotide binding]; other site 1179773001649 putative Zn2+ binding site [ion binding]; other site 1179773001650 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1179773001651 putative hydrophobic ligand binding site [chemical binding]; other site 1179773001652 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1179773001653 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773001654 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773001655 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773001656 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773001657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001659 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773001660 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1179773001661 putative catalytic residues [active] 1179773001662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773001663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773001664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773001665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773001666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773001667 dimerization interface [polypeptide binding]; other site 1179773001668 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773001669 cleavage site 1179773001670 active site 1179773001671 substrate binding sites [chemical binding]; other site 1179773001672 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1179773001673 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773001674 AAA ATPase domain; Region: AAA_16; pfam13191 1179773001675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773001676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773001677 DNA binding residues [nucleotide binding] 1179773001678 dimerization interface [polypeptide binding]; other site 1179773001679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773001680 Fic/DOC family; Region: Fic; pfam02661 1179773001681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773001682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001683 non-specific DNA binding site [nucleotide binding]; other site 1179773001684 salt bridge; other site 1179773001685 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001686 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773001687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773001688 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 1179773001689 active site 1179773001690 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1179773001691 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1179773001692 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1179773001693 active site 1179773001694 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1179773001695 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1179773001696 sugar binding site [chemical binding]; other site 1179773001697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773001698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773001699 active site 1179773001700 phosphorylation site [posttranslational modification] 1179773001701 intermolecular recognition site; other site 1179773001702 dimerization interface [polypeptide binding]; other site 1179773001703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773001704 dimerization interface [polypeptide binding]; other site 1179773001705 DNA binding residues [nucleotide binding] 1179773001706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773001707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773001708 metal binding site [ion binding]; metal-binding site 1179773001709 active site 1179773001710 I-site; other site 1179773001711 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1179773001712 putative FMN binding site [chemical binding]; other site 1179773001713 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1179773001714 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1179773001715 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1179773001716 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1179773001717 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1179773001718 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1179773001719 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1179773001720 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773001721 catalytic core [active] 1179773001722 EthD domain; Region: EthD; cl17553 1179773001723 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 1179773001724 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773001725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773001726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1179773001727 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1179773001728 Predicted membrane protein [Function unknown]; Region: COG2860 1179773001729 UPF0126 domain; Region: UPF0126; pfam03458 1179773001730 UPF0126 domain; Region: UPF0126; pfam03458 1179773001731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773001732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773001733 active site 1179773001734 phosphorylation site [posttranslational modification] 1179773001735 intermolecular recognition site; other site 1179773001736 dimerization interface [polypeptide binding]; other site 1179773001737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773001738 DNA binding site [nucleotide binding] 1179773001739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773001740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773001741 dimerization interface [polypeptide binding]; other site 1179773001742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773001743 dimer interface [polypeptide binding]; other site 1179773001744 phosphorylation site [posttranslational modification] 1179773001745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773001746 ATP binding site [chemical binding]; other site 1179773001747 Mg2+ binding site [ion binding]; other site 1179773001748 G-X-G motif; other site 1179773001749 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1179773001750 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1179773001751 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1179773001752 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1179773001753 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1179773001754 dimer interface [polypeptide binding]; other site 1179773001755 active site 1179773001756 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773001757 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1179773001758 protein binding site [polypeptide binding]; other site 1179773001759 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773001760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773001761 DNA binding residues [nucleotide binding] 1179773001762 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1179773001763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1179773001764 ligand binding site [chemical binding]; other site 1179773001765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773001766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773001767 active site 1179773001768 phosphorylation site [posttranslational modification] 1179773001769 intermolecular recognition site; other site 1179773001770 dimerization interface [polypeptide binding]; other site 1179773001771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773001772 DNA binding site [nucleotide binding] 1179773001773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773001774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773001775 dimer interface [polypeptide binding]; other site 1179773001776 phosphorylation site [posttranslational modification] 1179773001777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773001778 ATP binding site [chemical binding]; other site 1179773001779 Mg2+ binding site [ion binding]; other site 1179773001780 G-X-G motif; other site 1179773001781 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1179773001782 MPT binding site; other site 1179773001783 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1179773001784 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1179773001785 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1179773001786 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1179773001787 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1179773001788 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1179773001789 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1179773001790 active site 1179773001791 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1179773001792 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1179773001793 dimer interface [polypeptide binding]; other site 1179773001794 putative functional site; other site 1179773001795 putative MPT binding site; other site 1179773001796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773001797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773001798 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1179773001799 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1179773001800 dimer interface [polypeptide binding]; other site 1179773001801 motif 1; other site 1179773001802 active site 1179773001803 motif 2; other site 1179773001804 motif 3; other site 1179773001805 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773001806 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773001807 ligand binding site [chemical binding]; other site 1179773001808 flexible hinge region; other site 1179773001809 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1179773001810 PHP-associated; Region: PHP_C; pfam13263 1179773001811 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1179773001812 Part of AAA domain; Region: AAA_19; pfam13245 1179773001813 Family description; Region: UvrD_C_2; pfam13538 1179773001814 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1179773001815 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773001816 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1179773001817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001819 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773001820 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773001821 active site 1179773001822 ATP binding site [chemical binding]; other site 1179773001823 substrate binding site [chemical binding]; other site 1179773001824 activation loop (A-loop); other site 1179773001825 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1179773001826 Predicted methyltransferases [General function prediction only]; Region: COG0313 1179773001827 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1179773001828 putative SAM binding site [chemical binding]; other site 1179773001829 putative homodimer interface [polypeptide binding]; other site 1179773001830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001831 non-specific DNA binding site [nucleotide binding]; other site 1179773001832 salt bridge; other site 1179773001833 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001834 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773001835 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1179773001836 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1179773001837 active site 1179773001838 HIGH motif; other site 1179773001839 KMSKS motif; other site 1179773001840 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1179773001841 tRNA binding surface [nucleotide binding]; other site 1179773001842 anticodon binding site; other site 1179773001843 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1179773001844 active site 1179773001845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1179773001846 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1179773001847 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1179773001848 G5 domain; Region: G5; pfam07501 1179773001849 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1179773001850 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1179773001851 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1179773001852 S-adenosylmethionine binding site [chemical binding]; other site 1179773001853 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1179773001854 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1179773001855 Walker A/P-loop; other site 1179773001856 ATP binding site [chemical binding]; other site 1179773001857 Q-loop/lid; other site 1179773001858 ABC transporter signature motif; other site 1179773001859 Walker B; other site 1179773001860 D-loop; other site 1179773001861 H-loop/switch region; other site 1179773001862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001863 dimer interface [polypeptide binding]; other site 1179773001864 conserved gate region; other site 1179773001865 ABC-ATPase subunit interface; other site 1179773001866 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1179773001867 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1179773001868 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1179773001869 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1179773001870 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1179773001871 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1179773001872 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773001873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773001874 ABC transporter; Region: ABC_tran_2; pfam12848 1179773001875 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773001876 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001877 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001878 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001879 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001880 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1179773001881 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001882 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1179773001883 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1179773001884 acyl-activating enzyme (AAE) consensus motif; other site 1179773001885 active site 1179773001886 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1179773001887 putative active site [active] 1179773001888 catalytic residue [active] 1179773001889 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001890 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1179773001891 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001892 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001893 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773001894 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1179773001895 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1179773001896 5S rRNA interface [nucleotide binding]; other site 1179773001897 CTC domain interface [polypeptide binding]; other site 1179773001898 L16 interface [polypeptide binding]; other site 1179773001899 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1179773001900 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1179773001901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1179773001902 active site 1179773001903 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1179773001904 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1179773001905 Substrate binding site; other site 1179773001906 Mg++ binding site; other site 1179773001907 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1179773001908 active site 1179773001909 substrate binding site [chemical binding]; other site 1179773001910 CoA binding site [chemical binding]; other site 1179773001911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773001912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773001913 metal binding site [ion binding]; metal-binding site 1179773001914 active site 1179773001915 I-site; other site 1179773001916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773001917 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773001918 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1179773001919 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1179773001920 Di-iron ligands [ion binding]; other site 1179773001921 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1179773001922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773001923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773001924 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1179773001925 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1179773001926 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1179773001927 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1179773001928 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1179773001929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773001930 ATP binding site [chemical binding]; other site 1179773001931 putative Mg++ binding site [ion binding]; other site 1179773001932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773001933 nucleotide binding region [chemical binding]; other site 1179773001934 ATP-binding site [chemical binding]; other site 1179773001935 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1179773001936 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1179773001937 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1179773001938 homodimer interface [polypeptide binding]; other site 1179773001939 metal binding site [ion binding]; metal-binding site 1179773001940 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1179773001941 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773001942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773001943 non-specific DNA binding site [nucleotide binding]; other site 1179773001944 salt bridge; other site 1179773001945 sequence-specific DNA binding site [nucleotide binding]; other site 1179773001946 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773001947 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1179773001948 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773001949 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1179773001950 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1179773001951 Domain interface; other site 1179773001952 Peptide binding site; other site 1179773001953 Active site tetrad [active] 1179773001954 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1179773001955 DJ-1 family protein; Region: not_thiJ; TIGR01383 1179773001956 conserved cys residue [active] 1179773001957 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1179773001958 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773001959 conserved cys residue [active] 1179773001960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773001961 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1179773001962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1179773001963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1179773001964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773001965 TPR repeat; Region: TPR_11; pfam13414 1179773001966 binding surface 1179773001967 TPR motif; other site 1179773001968 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1179773001969 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773001970 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773001971 Cytochrome P450; Region: p450; cl12078 1179773001972 enolase; Provisional; Region: eno; PRK00077 1179773001973 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1179773001974 dimer interface [polypeptide binding]; other site 1179773001975 metal binding site [ion binding]; metal-binding site 1179773001976 substrate binding pocket [chemical binding]; other site 1179773001977 Septum formation initiator; Region: DivIC; pfam04977 1179773001978 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1179773001979 Protein of unknown function (DUF501); Region: DUF501; cl00652 1179773001980 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1179773001981 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1179773001982 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1179773001983 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1179773001984 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1179773001985 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1179773001986 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773001987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773001988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001989 dimer interface [polypeptide binding]; other site 1179773001990 conserved gate region; other site 1179773001991 putative PBP binding loops; other site 1179773001992 ABC-ATPase subunit interface; other site 1179773001993 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773001994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773001995 dimer interface [polypeptide binding]; other site 1179773001996 conserved gate region; other site 1179773001997 putative PBP binding loops; other site 1179773001998 ABC-ATPase subunit interface; other site 1179773001999 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773002000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773002001 Walker A/P-loop; other site 1179773002002 ATP binding site [chemical binding]; other site 1179773002003 Q-loop/lid; other site 1179773002004 ABC transporter signature motif; other site 1179773002005 Walker B; other site 1179773002006 D-loop; other site 1179773002007 H-loop/switch region; other site 1179773002008 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773002009 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1179773002010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773002011 Walker A/P-loop; other site 1179773002012 ATP binding site [chemical binding]; other site 1179773002013 Q-loop/lid; other site 1179773002014 ABC transporter signature motif; other site 1179773002015 Walker B; other site 1179773002016 D-loop; other site 1179773002017 H-loop/switch region; other site 1179773002018 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773002019 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1179773002020 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1179773002021 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1179773002022 Fe-S cluster binding site [ion binding]; other site 1179773002023 DNA binding site [nucleotide binding] 1179773002024 active site 1179773002025 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1179773002026 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773002027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773002028 ATP binding site [chemical binding]; other site 1179773002029 Walker A motif; other site 1179773002030 Walker B motif; other site 1179773002031 arginine finger; other site 1179773002032 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773002033 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1179773002034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773002035 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1179773002036 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1179773002037 NADPH bind site [chemical binding]; other site 1179773002038 putative FMN binding site [chemical binding]; other site 1179773002039 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773002040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773002042 active site 1179773002043 phosphorylation site [posttranslational modification] 1179773002044 intermolecular recognition site; other site 1179773002045 dimerization interface [polypeptide binding]; other site 1179773002046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773002047 DNA binding residues [nucleotide binding] 1179773002048 dimerization interface [polypeptide binding]; other site 1179773002049 Putative sensor; Region: Sensor; pfam13796 1179773002050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773002051 Histidine kinase; Region: HisKA_3; pfam07730 1179773002052 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773002053 ATP binding site [chemical binding]; other site 1179773002054 Mg2+ binding site [ion binding]; other site 1179773002055 G-X-G motif; other site 1179773002056 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1179773002057 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1179773002058 coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109 1179773002059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773002060 FeS/SAM binding site; other site 1179773002061 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1179773002062 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1179773002063 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1179773002064 PqqA family; Region: PqqA; cl15372 1179773002065 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1179773002066 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1179773002067 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1179773002068 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1179773002069 active site 1179773002070 putative catalytic site [active] 1179773002071 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1179773002072 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1179773002073 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1179773002074 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773002075 dimer interface [polypeptide binding]; other site 1179773002076 active site 1179773002077 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1179773002078 active site 1179773002079 catalytic triad [active] 1179773002080 oxyanion hole [active] 1179773002081 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1179773002082 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1179773002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002084 catalytic residue [active] 1179773002085 dimer interface [polypeptide binding]; other site 1179773002086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1179773002087 RDD family; Region: RDD; pfam06271 1179773002088 cystathionine gamma-synthase; Provisional; Region: PRK07811 1179773002089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1179773002090 homodimer interface [polypeptide binding]; other site 1179773002091 substrate-cofactor binding pocket; other site 1179773002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002093 catalytic residue [active] 1179773002094 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1179773002095 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1179773002096 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1179773002097 dimer interface [polypeptide binding]; other site 1179773002098 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1179773002099 active site 1179773002100 Fe binding site [ion binding]; other site 1179773002101 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773002102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1179773002103 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773002104 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1179773002105 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1179773002106 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1179773002107 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1179773002108 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1179773002109 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773002110 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1179773002111 active site 1179773002112 metal binding site [ion binding]; metal-binding site 1179773002113 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1179773002114 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1179773002115 catalytic residues [active] 1179773002116 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1179773002117 Zn binding site [ion binding]; other site 1179773002118 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1179773002119 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1179773002120 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1179773002121 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1179773002122 catalytic residue [active] 1179773002123 putative FPP diphosphate binding site; other site 1179773002124 putative FPP binding hydrophobic cleft; other site 1179773002125 dimer interface [polypeptide binding]; other site 1179773002126 putative IPP diphosphate binding site; other site 1179773002127 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773002128 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1179773002129 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1179773002130 putative active site [active] 1179773002131 PhoH-like protein; Region: PhoH; pfam02562 1179773002132 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773002133 metal ion-dependent adhesion site (MIDAS); other site 1179773002134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002135 Walker A/P-loop; other site 1179773002136 ATP binding site [chemical binding]; other site 1179773002137 Q-loop/lid; other site 1179773002138 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1179773002139 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1179773002140 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1179773002141 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773002142 phosphate binding site [ion binding]; other site 1179773002143 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1179773002144 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1179773002145 active site 1179773002146 DNA binding site [nucleotide binding] 1179773002147 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1179773002148 DNA binding site [nucleotide binding] 1179773002149 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773002150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773002151 DNA-binding site [nucleotide binding]; DNA binding site 1179773002152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773002153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002154 homodimer interface [polypeptide binding]; other site 1179773002155 catalytic residue [active] 1179773002156 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1179773002157 Class II fumarases; Region: Fumarase_classII; cd01362 1179773002158 active site 1179773002159 tetramer interface [polypeptide binding]; other site 1179773002160 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1179773002161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773002162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773002163 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773002164 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773002165 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773002166 cleavage site 1179773002167 active site 1179773002168 substrate binding sites [chemical binding]; other site 1179773002169 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1179773002170 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1179773002171 putative active site [active] 1179773002172 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1179773002173 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1179773002174 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1179773002175 generic binding surface II; other site 1179773002176 generic binding surface I; other site 1179773002177 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1179773002178 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1179773002179 RmuC family; Region: RmuC; pfam02646 1179773002180 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1179773002181 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1179773002182 active site 1179773002183 metal binding site [ion binding]; metal-binding site 1179773002184 DNA binding site [nucleotide binding] 1179773002185 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1179773002186 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1179773002187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002188 Walker A/P-loop; other site 1179773002189 ATP binding site [chemical binding]; other site 1179773002190 Q-loop/lid; other site 1179773002191 ABC transporter signature motif; other site 1179773002192 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1179773002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002194 ABC transporter signature motif; other site 1179773002195 Walker B; other site 1179773002196 D-loop; other site 1179773002197 H-loop/switch region; other site 1179773002198 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773002199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773002200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773002201 active site 1179773002202 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773002203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773002204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002205 Walker A/P-loop; other site 1179773002206 ATP binding site [chemical binding]; other site 1179773002207 Q-loop/lid; other site 1179773002208 ABC transporter signature motif; other site 1179773002209 Walker B; other site 1179773002210 D-loop; other site 1179773002211 H-loop/switch region; other site 1179773002212 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1179773002213 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1179773002214 DNA binding site [nucleotide binding] 1179773002215 active site 1179773002216 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1179773002217 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773002218 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1179773002219 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1179773002220 GTP-binding protein YchF; Reviewed; Region: PRK09601 1179773002221 YchF GTPase; Region: YchF; cd01900 1179773002222 G1 box; other site 1179773002223 GTP/Mg2+ binding site [chemical binding]; other site 1179773002224 Switch I region; other site 1179773002225 G2 box; other site 1179773002226 Switch II region; other site 1179773002227 G3 box; other site 1179773002228 G4 box; other site 1179773002229 G5 box; other site 1179773002230 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1179773002231 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1179773002232 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1179773002233 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1179773002234 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1179773002235 aromatic arch; other site 1179773002236 DCoH dimer interaction site [polypeptide binding]; other site 1179773002237 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1179773002238 DCoH tetramer interaction site [polypeptide binding]; other site 1179773002239 substrate binding site [chemical binding]; other site 1179773002240 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1179773002241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1179773002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773002243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002244 dimer interface [polypeptide binding]; other site 1179773002245 conserved gate region; other site 1179773002246 putative PBP binding loops; other site 1179773002247 ABC-ATPase subunit interface; other site 1179773002248 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1179773002249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002250 Walker A/P-loop; other site 1179773002251 ATP binding site [chemical binding]; other site 1179773002252 Q-loop/lid; other site 1179773002253 ABC transporter signature motif; other site 1179773002254 Walker B; other site 1179773002255 D-loop; other site 1179773002256 H-loop/switch region; other site 1179773002257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773002258 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773002259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773002260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002261 Walker A/P-loop; other site 1179773002262 ATP binding site [chemical binding]; other site 1179773002263 Q-loop/lid; other site 1179773002264 ABC transporter signature motif; other site 1179773002265 Walker B; other site 1179773002266 D-loop; other site 1179773002267 H-loop/switch region; other site 1179773002268 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1179773002269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773002270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773002271 active site 1179773002272 phosphorylation site [posttranslational modification] 1179773002273 intermolecular recognition site; other site 1179773002274 dimerization interface [polypeptide binding]; other site 1179773002275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773002276 DNA binding site [nucleotide binding] 1179773002277 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1179773002278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773002279 dimer interface [polypeptide binding]; other site 1179773002280 phosphorylation site [posttranslational modification] 1179773002281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773002282 ATP binding site [chemical binding]; other site 1179773002283 Mg2+ binding site [ion binding]; other site 1179773002284 G-X-G motif; other site 1179773002285 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773002286 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1179773002287 active site 1179773002288 8-oxo-dGMP binding site [chemical binding]; other site 1179773002289 nudix motif; other site 1179773002290 metal binding site [ion binding]; metal-binding site 1179773002291 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1179773002292 active site 1179773002293 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1179773002294 HIGH motif; other site 1179773002295 dimer interface [polypeptide binding]; other site 1179773002296 KMSKS motif; other site 1179773002297 YCII-related domain; Region: YCII; cl00999 1179773002298 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1179773002299 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1179773002300 G1 box; other site 1179773002301 putative GEF interaction site [polypeptide binding]; other site 1179773002302 GTP/Mg2+ binding site [chemical binding]; other site 1179773002303 Switch I region; other site 1179773002304 G2 box; other site 1179773002305 G3 box; other site 1179773002306 Switch II region; other site 1179773002307 G4 box; other site 1179773002308 G5 box; other site 1179773002309 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1179773002310 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1179773002311 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1179773002312 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773002313 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1179773002314 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773002315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002317 dimer interface [polypeptide binding]; other site 1179773002318 conserved gate region; other site 1179773002319 putative PBP binding loops; other site 1179773002320 ABC-ATPase subunit interface; other site 1179773002321 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773002322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002323 dimer interface [polypeptide binding]; other site 1179773002324 conserved gate region; other site 1179773002325 putative PBP binding loops; other site 1179773002326 ABC-ATPase subunit interface; other site 1179773002327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773002328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773002329 Walker A/P-loop; other site 1179773002330 ATP binding site [chemical binding]; other site 1179773002331 Q-loop/lid; other site 1179773002332 ABC transporter signature motif; other site 1179773002333 Walker B; other site 1179773002334 D-loop; other site 1179773002335 H-loop/switch region; other site 1179773002336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773002337 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1179773002338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773002339 Walker A/P-loop; other site 1179773002340 ATP binding site [chemical binding]; other site 1179773002341 Q-loop/lid; other site 1179773002342 ABC transporter signature motif; other site 1179773002343 Walker B; other site 1179773002344 D-loop; other site 1179773002345 H-loop/switch region; other site 1179773002346 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773002347 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1179773002348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773002349 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1179773002350 Coenzyme A binding pocket [chemical binding]; other site 1179773002351 Ferredoxin [Energy production and conversion]; Region: COG1146 1179773002352 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773002353 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1179773002354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773002355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002356 homodimer interface [polypeptide binding]; other site 1179773002357 catalytic residue [active] 1179773002358 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1179773002359 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773002360 putative trimer interface [polypeptide binding]; other site 1179773002361 putative CoA binding site [chemical binding]; other site 1179773002362 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1179773002363 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1179773002364 metal binding site [ion binding]; metal-binding site 1179773002365 putative dimer interface [polypeptide binding]; other site 1179773002366 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1179773002367 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1179773002368 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1179773002369 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1179773002370 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1179773002371 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1179773002372 dihydropteroate synthase; Region: DHPS; TIGR01496 1179773002373 substrate binding pocket [chemical binding]; other site 1179773002374 dimer interface [polypeptide binding]; other site 1179773002375 inhibitor binding site; inhibition site 1179773002376 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773002377 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773002378 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773002379 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1179773002380 hydrophobic ligand binding site; other site 1179773002381 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1179773002382 enoyl-CoA hydratase; Provisional; Region: PRK08140 1179773002383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773002384 substrate binding site [chemical binding]; other site 1179773002385 oxyanion hole (OAH) forming residues; other site 1179773002386 trimer interface [polypeptide binding]; other site 1179773002387 PaaX-like protein; Region: PaaX; pfam07848 1179773002388 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1179773002389 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1179773002390 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1179773002391 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1179773002392 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1179773002393 interface (dimer of trimers) [polypeptide binding]; other site 1179773002394 Substrate-binding/catalytic site; other site 1179773002395 Zn-binding sites [ion binding]; other site 1179773002396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773002397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773002398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773002399 dimerization interface [polypeptide binding]; other site 1179773002400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773002401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773002402 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1179773002403 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773002404 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1179773002405 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1179773002406 ligand binding site; other site 1179773002407 oligomer interface; other site 1179773002408 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1179773002409 sulfate 1 binding site; other site 1179773002410 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1179773002411 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1179773002412 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773002413 conserved cys residue [active] 1179773002414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773002415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773002416 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1179773002417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773002418 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1179773002419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773002420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773002421 DNA binding residues [nucleotide binding] 1179773002422 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1179773002423 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773002424 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1179773002425 sec-independent translocase; Provisional; Region: PRK03100 1179773002426 sec-independent translocase; Provisional; Region: tatB; PRK00404 1179773002427 Domain of unknown function DUF59; Region: DUF59; cl00941 1179773002428 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1179773002429 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1179773002430 MarR family; Region: MarR; pfam01047 1179773002431 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1179773002432 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1179773002433 PRC-barrel domain; Region: PRC; pfam05239 1179773002434 MgtE intracellular N domain; Region: MgtE_N; smart00924 1179773002435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1179773002436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773002437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773002438 Coenzyme A binding pocket [chemical binding]; other site 1179773002439 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1179773002440 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1179773002441 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1179773002442 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1179773002443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773002444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773002445 active site 1179773002446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773002447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773002448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1179773002449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002450 dimer interface [polypeptide binding]; other site 1179773002451 conserved gate region; other site 1179773002452 putative PBP binding loops; other site 1179773002453 ABC-ATPase subunit interface; other site 1179773002454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773002455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002456 dimer interface [polypeptide binding]; other site 1179773002457 conserved gate region; other site 1179773002458 putative PBP binding loops; other site 1179773002459 ABC-ATPase subunit interface; other site 1179773002460 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1179773002461 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1179773002462 Walker A/P-loop; other site 1179773002463 ATP binding site [chemical binding]; other site 1179773002464 Q-loop/lid; other site 1179773002465 ABC transporter signature motif; other site 1179773002466 Walker B; other site 1179773002467 D-loop; other site 1179773002468 H-loop/switch region; other site 1179773002469 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1179773002470 classical (c) SDRs; Region: SDR_c; cd05233 1179773002471 NAD(P) binding site [chemical binding]; other site 1179773002472 active site 1179773002473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773002474 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773002475 active site 1179773002476 metal binding site [ion binding]; metal-binding site 1179773002477 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1179773002478 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1179773002479 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1179773002480 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1179773002481 oligomer interface [polypeptide binding]; other site 1179773002482 metal binding site [ion binding]; metal-binding site 1179773002483 metal binding site [ion binding]; metal-binding site 1179773002484 putative Cl binding site [ion binding]; other site 1179773002485 basic sphincter; other site 1179773002486 hydrophobic gate; other site 1179773002487 periplasmic entrance; other site 1179773002488 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1179773002489 putative active site [active] 1179773002490 putative catalytic site [active] 1179773002491 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1179773002492 Bacterial PH domain; Region: DUF304; pfam03703 1179773002493 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1179773002494 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1179773002495 active site 1179773002496 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1179773002497 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1179773002498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773002499 PQQ-like domain; Region: PQQ_2; pfam13360 1179773002500 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1179773002501 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1179773002502 ATP binding site [chemical binding]; other site 1179773002503 Mg++ binding site [ion binding]; other site 1179773002504 motif III; other site 1179773002505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773002506 nucleotide binding region [chemical binding]; other site 1179773002507 ATP-binding site [chemical binding]; other site 1179773002508 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1179773002509 dinuclear metal binding motif [ion binding]; other site 1179773002510 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1179773002511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773002512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773002513 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1179773002514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773002515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773002516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773002517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773002518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773002519 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773002520 catalytic site [active] 1179773002521 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1179773002522 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1179773002523 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1179773002524 ATP binding site [chemical binding]; other site 1179773002525 substrate interface [chemical binding]; other site 1179773002526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1179773002527 active site residue [active] 1179773002528 TIGR02569 family protein; Region: TIGR02569_actnb 1179773002529 Pirin-related protein [General function prediction only]; Region: COG1741 1179773002530 Pirin; Region: Pirin; pfam02678 1179773002531 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1179773002532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773002533 binding surface 1179773002534 TPR motif; other site 1179773002535 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1179773002536 DNA binding site [nucleotide binding] 1179773002537 active site 1179773002538 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1179773002539 active site 1179773002540 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1179773002541 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1179773002542 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1179773002543 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1179773002544 Predicted membrane protein [Function unknown]; Region: COG4270 1179773002545 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773002546 hypothetical protein; Provisional; Region: PRK08201 1179773002547 metal binding site [ion binding]; metal-binding site 1179773002548 Ion channel; Region: Ion_trans_2; pfam07885 1179773002549 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1179773002550 TrkA-N domain; Region: TrkA_N; pfam02254 1179773002551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1179773002552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773002553 dimerization interface [polypeptide binding]; other site 1179773002554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773002555 dimer interface [polypeptide binding]; other site 1179773002556 phosphorylation site [posttranslational modification] 1179773002557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773002558 ATP binding site [chemical binding]; other site 1179773002559 Mg2+ binding site [ion binding]; other site 1179773002560 G-X-G motif; other site 1179773002561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773002562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773002563 active site 1179773002564 phosphorylation site [posttranslational modification] 1179773002565 intermolecular recognition site; other site 1179773002566 dimerization interface [polypeptide binding]; other site 1179773002567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773002568 DNA binding site [nucleotide binding] 1179773002569 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773002570 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773002571 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1179773002572 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1179773002573 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1179773002574 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1179773002575 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1179773002576 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1179773002577 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1179773002578 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1179773002579 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1179773002580 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1179773002581 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1179773002582 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1179773002583 putative NADH binding site [chemical binding]; other site 1179773002584 putative active site [active] 1179773002585 nudix motif; other site 1179773002586 putative metal binding site [ion binding]; other site 1179773002587 NmrA-like family; Region: NmrA; pfam05368 1179773002588 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1179773002589 NADP binding site [chemical binding]; other site 1179773002590 active site 1179773002591 regulatory binding site [polypeptide binding]; other site 1179773002592 MarR family; Region: MarR; pfam01047 1179773002593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773002594 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773002595 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773002596 nucleotide binding site [chemical binding]; other site 1179773002597 TIGR02680 family protein; Region: TIGR02680 1179773002598 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1179773002599 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1179773002600 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 1179773002601 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1179773002602 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1179773002603 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1179773002604 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1179773002605 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773002606 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1179773002607 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1179773002608 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1179773002609 active site 1179773002610 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1179773002611 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1179773002612 substrate binding pocket [chemical binding]; other site 1179773002613 chain length determination region; other site 1179773002614 substrate-Mg2+ binding site; other site 1179773002615 catalytic residues [active] 1179773002616 aspartate-rich region 1; other site 1179773002617 active site lid residues [active] 1179773002618 aspartate-rich region 2; other site 1179773002619 hypothetical protein; Provisional; Region: PRK07908 1179773002620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773002621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002622 homodimer interface [polypeptide binding]; other site 1179773002623 catalytic residue [active] 1179773002624 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1179773002625 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1179773002626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1179773002627 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1179773002628 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1179773002629 Putative zinc ribbon domain; Region: DUF164; pfam02591 1179773002630 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1179773002631 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1179773002632 RNA/DNA hybrid binding site [nucleotide binding]; other site 1179773002633 active site 1179773002634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773002635 catalytic core [active] 1179773002636 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1179773002637 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773002638 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773002639 AAA-like domain; Region: AAA_10; pfam12846 1179773002640 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773002641 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773002642 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1179773002643 NAD synthetase; Provisional; Region: PRK13981 1179773002644 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1179773002645 multimer interface [polypeptide binding]; other site 1179773002646 active site 1179773002647 catalytic triad [active] 1179773002648 protein interface 1 [polypeptide binding]; other site 1179773002649 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1179773002650 homodimer interface [polypeptide binding]; other site 1179773002651 NAD binding pocket [chemical binding]; other site 1179773002652 ATP binding pocket [chemical binding]; other site 1179773002653 Mg binding site [ion binding]; other site 1179773002654 active-site loop [active] 1179773002655 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773002656 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773002657 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773002658 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1179773002659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773002660 NAD(P) binding site [chemical binding]; other site 1179773002661 active site 1179773002662 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1179773002663 oligomerization interface [polypeptide binding]; other site 1179773002664 active site 1179773002665 metal binding site [ion binding]; metal-binding site 1179773002666 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1179773002667 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773002668 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773002669 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773002670 intersubunit interface [polypeptide binding]; other site 1179773002671 RNB domain; Region: RNB; pfam00773 1179773002672 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1179773002673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773002674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773002675 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1179773002676 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1179773002677 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1179773002678 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1179773002679 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1179773002680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773002681 non-specific DNA binding site [nucleotide binding]; other site 1179773002682 salt bridge; other site 1179773002683 sequence-specific DNA binding site [nucleotide binding]; other site 1179773002684 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773002685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773002686 dimerization interface [polypeptide binding]; other site 1179773002687 putative Zn2+ binding site [ion binding]; other site 1179773002688 putative DNA binding site [nucleotide binding]; other site 1179773002689 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773002690 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1179773002691 active site residue [active] 1179773002692 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1179773002693 catalytic triad [active] 1179773002694 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1179773002695 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1179773002696 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1179773002697 metal binding triad; other site 1179773002698 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1179773002699 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1179773002700 metal binding triad; other site 1179773002701 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1179773002702 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773002703 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1179773002704 putative NAD(P) binding site [chemical binding]; other site 1179773002705 glutamine synthetase, type I; Region: GlnA; TIGR00653 1179773002706 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1179773002707 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1179773002708 RDD family; Region: RDD; pfam06271 1179773002709 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1179773002710 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1179773002711 Part of AAA domain; Region: AAA_19; pfam13245 1179773002712 Family description; Region: UvrD_C_2; pfam13538 1179773002713 HRDC domain; Region: HRDC; pfam00570 1179773002714 Transcription factor WhiB; Region: Whib; pfam02467 1179773002715 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 1179773002716 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1179773002717 ABC1 family; Region: ABC1; cl17513 1179773002718 Protein of unknown function DUF45; Region: DUF45; cl00636 1179773002719 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1179773002720 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1179773002721 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1179773002722 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1179773002723 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1179773002724 hypothetical protein; Validated; Region: PRK00068 1179773002725 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1179773002726 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1179773002727 RF-1 domain; Region: RF-1; pfam00472 1179773002728 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1179773002729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002730 Walker A/P-loop; other site 1179773002731 ATP binding site [chemical binding]; other site 1179773002732 Q-loop/lid; other site 1179773002733 ABC transporter signature motif; other site 1179773002734 Walker B; other site 1179773002735 D-loop; other site 1179773002736 H-loop/switch region; other site 1179773002737 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1179773002738 FtsX-like permease family; Region: FtsX; pfam02687 1179773002739 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1179773002740 SmpB-tmRNA interface; other site 1179773002741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773002742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773002743 active site 1179773002744 phosphorylation site [posttranslational modification] 1179773002745 intermolecular recognition site; other site 1179773002746 dimerization interface [polypeptide binding]; other site 1179773002747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773002748 DNA binding residues [nucleotide binding] 1179773002749 Putative sensor; Region: Sensor; pfam13796 1179773002750 Histidine kinase; Region: HisKA_3; pfam07730 1179773002751 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773002752 Mg2+ binding site [ion binding]; other site 1179773002753 G-X-G motif; other site 1179773002754 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1179773002755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773002756 nucleotide binding region [chemical binding]; other site 1179773002757 ATP-binding site [chemical binding]; other site 1179773002758 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1179773002759 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1179773002760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773002761 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1179773002762 DXD motif; other site 1179773002763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773002764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773002765 putative substrate translocation pore; other site 1179773002766 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1179773002767 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1179773002768 catalytic residues [active] 1179773002769 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1179773002770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773002771 acyl-activating enzyme (AAE) consensus motif; other site 1179773002772 AMP binding site [chemical binding]; other site 1179773002773 active site 1179773002774 CoA binding site [chemical binding]; other site 1179773002775 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773002776 Helix-turn-helix domain; Region: HTH_38; pfam13936 1179773002777 Integrase core domain; Region: rve; pfam00665 1179773002778 TIGR02679 family protein; Region: TIGR02679 1179773002779 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 1179773002780 TIGR02677 family protein; Region: TIGR02677 1179773002781 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1179773002782 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 1179773002783 TIGR02680 family protein; Region: TIGR02680 1179773002784 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1179773002785 FtsX-like permease family; Region: FtsX; pfam02687 1179773002786 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773002787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002788 Walker A/P-loop; other site 1179773002789 ATP binding site [chemical binding]; other site 1179773002790 Q-loop/lid; other site 1179773002791 ABC transporter signature motif; other site 1179773002792 Walker B; other site 1179773002793 D-loop; other site 1179773002794 H-loop/switch region; other site 1179773002795 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1179773002796 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773002797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773002798 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1179773002799 Walker A/P-loop; other site 1179773002800 ATP binding site [chemical binding]; other site 1179773002801 Q-loop/lid; other site 1179773002802 ABC transporter signature motif; other site 1179773002803 Walker B; other site 1179773002804 D-loop; other site 1179773002805 H-loop/switch region; other site 1179773002806 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1179773002807 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1179773002808 Catalytic site [active] 1179773002809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773002810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773002811 non-specific DNA binding site [nucleotide binding]; other site 1179773002812 salt bridge; other site 1179773002813 sequence-specific DNA binding site [nucleotide binding]; other site 1179773002814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773002815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773002816 DNA binding site [nucleotide binding] 1179773002817 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1179773002818 TraB family; Region: TraB; cl12050 1179773002819 TIR domain; Region: TIR_2; cl17458 1179773002820 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773002821 P-loop; other site 1179773002822 Magnesium ion binding site [ion binding]; other site 1179773002823 Domain of unknown function DUF87; Region: DUF87; pfam01935 1179773002824 AAA-like domain; Region: AAA_10; pfam12846 1179773002825 Zonular occludens toxin (Zot); Region: Zot; cl17485 1179773002826 TIR domain; Region: TIR_2; pfam13676 1179773002827 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773002828 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773002829 NB-ARC domain; Region: NB-ARC; pfam00931 1179773002830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773002831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773002832 binding surface 1179773002833 TPR motif; other site 1179773002834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773002835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773002836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773002837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773002838 binding surface 1179773002839 TPR motif; other site 1179773002840 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773002841 metal ion-dependent adhesion site (MIDAS); other site 1179773002842 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1179773002843 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1179773002844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773002845 dimerization interface [polypeptide binding]; other site 1179773002846 putative DNA binding site [nucleotide binding]; other site 1179773002847 LexA repressor; Validated; Region: PRK00215 1179773002848 putative Zn2+ binding site [ion binding]; other site 1179773002849 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1179773002850 Catalytic site [active] 1179773002851 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1179773002852 Ligand binding site; other site 1179773002853 Putative Catalytic site; other site 1179773002854 DXD motif; other site 1179773002855 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1179773002856 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1179773002857 tetrameric interface [polypeptide binding]; other site 1179773002858 NAD binding site [chemical binding]; other site 1179773002859 catalytic residues [active] 1179773002860 substrate binding site [chemical binding]; other site 1179773002861 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773002862 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773002863 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773002864 hypothetical protein; Provisional; Region: PRK06541 1179773002865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773002866 inhibitor-cofactor binding pocket; inhibition site 1179773002867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773002868 catalytic residue [active] 1179773002869 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1179773002870 Amidase; Region: Amidase; cl11426 1179773002871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773002872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773002873 D-galactonate transporter; Region: 2A0114; TIGR00893 1179773002874 putative substrate translocation pore; other site 1179773002875 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1179773002876 classical (c) SDRs; Region: SDR_c; cd05233 1179773002877 NAD(P) binding site [chemical binding]; other site 1179773002878 active site 1179773002879 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1179773002880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773002881 catalytic residue [active] 1179773002882 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1179773002883 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1179773002884 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1179773002885 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1179773002886 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1179773002887 aminotransferase; Validated; Region: PRK07046 1179773002888 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773002889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773002890 catalytic residue [active] 1179773002891 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773002892 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1179773002893 NAD(P) binding site [chemical binding]; other site 1179773002894 catalytic residues [active] 1179773002895 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1179773002896 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773002897 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773002899 DNA-binding site [nucleotide binding]; DNA binding site 1179773002900 FCD domain; Region: FCD; pfam07729 1179773002901 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773002902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773002903 MarR family; Region: MarR_2; cl17246 1179773002904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773002905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773002906 active site 1179773002907 phosphorylation site [posttranslational modification] 1179773002908 intermolecular recognition site; other site 1179773002909 dimerization interface [polypeptide binding]; other site 1179773002910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773002911 DNA binding residues [nucleotide binding] 1179773002912 dimerization interface [polypeptide binding]; other site 1179773002913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773002914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773002915 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773002916 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773002917 Protein phosphatase 2C; Region: PP2C; pfam00481 1179773002918 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1179773002919 active site 1179773002920 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1179773002921 phosphopeptide binding site; other site 1179773002922 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773002923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773002924 active site 1179773002925 ATP binding site [chemical binding]; other site 1179773002926 substrate binding site [chemical binding]; other site 1179773002927 activation loop (A-loop); other site 1179773002928 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773002929 Interdomain contacts; other site 1179773002930 Cytokine receptor motif; other site 1179773002931 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773002932 Interdomain contacts; other site 1179773002933 Cytokine receptor motif; other site 1179773002934 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773002935 Interdomain contacts; other site 1179773002936 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773002937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773002938 Walker A motif; other site 1179773002939 ATP binding site [chemical binding]; other site 1179773002940 Walker B motif; other site 1179773002941 arginine finger; other site 1179773002942 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1179773002943 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773002944 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1179773002945 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1179773002946 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1179773002947 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1179773002948 active site 1179773002949 Zn binding site [ion binding]; other site 1179773002950 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1179773002951 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002953 dimer interface [polypeptide binding]; other site 1179773002954 conserved gate region; other site 1179773002955 putative PBP binding loops; other site 1179773002956 ABC-ATPase subunit interface; other site 1179773002957 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1179773002958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773002959 dimer interface [polypeptide binding]; other site 1179773002960 conserved gate region; other site 1179773002961 putative PBP binding loops; other site 1179773002962 ABC-ATPase subunit interface; other site 1179773002963 PBP superfamily domain; Region: PBP_like_2; cl17296 1179773002964 PBP superfamily domain; Region: PBP_like_2; cl17296 1179773002965 PBP superfamily domain; Region: PBP_like_2; cl17296 1179773002966 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1179773002967 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1179773002968 active site 1179773002969 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1179773002970 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1179773002971 Walker A/P-loop; other site 1179773002972 ATP binding site [chemical binding]; other site 1179773002973 Q-loop/lid; other site 1179773002974 ABC transporter signature motif; other site 1179773002975 Walker B; other site 1179773002976 D-loop; other site 1179773002977 H-loop/switch region; other site 1179773002978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773002979 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1179773002980 FecCD transport family; Region: FecCD; pfam01032 1179773002981 ABC-ATPase subunit interface; other site 1179773002982 dimer interface [polypeptide binding]; other site 1179773002983 putative PBP binding regions; other site 1179773002984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773002985 ABC-ATPase subunit interface; other site 1179773002986 dimer interface [polypeptide binding]; other site 1179773002987 putative PBP binding regions; other site 1179773002988 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773002989 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1179773002990 siderophore binding site; other site 1179773002991 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773002992 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773002993 Walker A/P-loop; other site 1179773002994 ATP binding site [chemical binding]; other site 1179773002995 Q-loop/lid; other site 1179773002996 ABC transporter signature motif; other site 1179773002997 Walker B; other site 1179773002998 D-loop; other site 1179773002999 H-loop/switch region; other site 1179773003000 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1179773003001 substrate binding pocket [chemical binding]; other site 1179773003002 substrate-Mg2+ binding site; other site 1179773003003 aspartate-rich region 1; other site 1179773003004 aspartate-rich region 2; other site 1179773003005 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1179773003006 substrate binding pocket [chemical binding]; other site 1179773003007 substrate-Mg2+ binding site; other site 1179773003008 aspartate-rich region 1; other site 1179773003009 aspartate-rich region 2; other site 1179773003010 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773003011 DNA binding site [nucleotide binding] 1179773003012 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773003013 TPR repeat; Region: TPR_11; pfam13414 1179773003014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773003015 TPR motif; other site 1179773003016 binding surface 1179773003017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773003018 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1179773003019 RHS Repeat; Region: RHS_repeat; pfam05593 1179773003020 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773003021 RHS Repeat; Region: RHS_repeat; pfam05593 1179773003022 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773003023 RHS Repeat; Region: RHS_repeat; pfam05593 1179773003024 RHS Repeat; Region: RHS_repeat; pfam05593 1179773003025 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773003026 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773003027 protein-splicing catalytic site; other site 1179773003028 thioester formation/cholesterol transfer; other site 1179773003029 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1179773003030 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773003031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773003032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773003033 non-specific DNA binding site [nucleotide binding]; other site 1179773003034 salt bridge; other site 1179773003035 sequence-specific DNA binding site [nucleotide binding]; other site 1179773003036 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1179773003037 catalytic site [active] 1179773003038 BNR repeat-like domain; Region: BNR_2; pfam13088 1179773003039 Asp-box motif; other site 1179773003040 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773003041 Laminin G domain; Region: LamG; smart00282 1179773003042 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1179773003043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1179773003044 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773003045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773003046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773003047 binding surface 1179773003048 TPR motif; other site 1179773003049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773003050 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773003051 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773003052 homodimer interface [polypeptide binding]; other site 1179773003053 active site 1179773003054 TDP-binding site; other site 1179773003055 acceptor substrate-binding pocket; other site 1179773003056 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773003057 putative sugar binding sites [chemical binding]; other site 1179773003058 Q-X-W motif; other site 1179773003059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773003060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773003061 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773003062 Predicted flavoprotein [General function prediction only]; Region: COG0431 1179773003063 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773003064 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773003065 NAD(P) binding site [chemical binding]; other site 1179773003066 AAA ATPase domain; Region: AAA_16; pfam13191 1179773003067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773003068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773003069 DNA binding residues [nucleotide binding] 1179773003070 dimerization interface [polypeptide binding]; other site 1179773003071 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1179773003072 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1179773003073 active site 1179773003074 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1179773003075 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1179773003076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773003077 active site 1179773003078 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1179773003079 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1179773003080 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1179773003081 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1179773003082 active site 1179773003083 ARD/ARD' family; Region: ARD; pfam03079 1179773003084 Cupin domain; Region: Cupin_2; cl17218 1179773003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1179773003086 serine/threonine protein kinase; Provisional; Region: PRK11768 1179773003087 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1179773003088 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1179773003089 D-pathway; other site 1179773003090 Putative ubiquinol binding site [chemical binding]; other site 1179773003091 Low-spin heme (heme b) binding site [chemical binding]; other site 1179773003092 Putative water exit pathway; other site 1179773003093 Binuclear center (heme o3/CuB) [ion binding]; other site 1179773003094 K-pathway; other site 1179773003095 Putative proton exit pathway; other site 1179773003096 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1179773003097 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1179773003098 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1179773003099 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1179773003100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773003101 motif II; other site 1179773003102 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1179773003103 dimer interface [polypeptide binding]; other site 1179773003104 putative active site [active] 1179773003105 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773003106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773003107 NAD(P) binding site [chemical binding]; other site 1179773003108 active site 1179773003109 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1179773003110 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1179773003111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1179773003112 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1179773003113 aminoglycoside resistance protein; Provisional; Region: PRK13746 1179773003114 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1179773003115 active site 1179773003116 NTP binding site [chemical binding]; other site 1179773003117 metal binding triad [ion binding]; metal-binding site 1179773003118 antibiotic binding site [chemical binding]; other site 1179773003119 BioY family; Region: BioY; pfam02632 1179773003120 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1179773003121 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1179773003122 active site 1179773003123 homodimer interface [polypeptide binding]; other site 1179773003124 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773003125 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773003126 catalytic triad [active] 1179773003127 conserved cis-peptide bond; other site 1179773003128 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1179773003129 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1179773003130 active site 1179773003131 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1179773003132 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1179773003133 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1179773003134 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1179773003135 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1179773003136 MPN+ (JAMM) motif; other site 1179773003137 Zinc-binding site [ion binding]; other site 1179773003138 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1179773003139 MoaE interaction surface [polypeptide binding]; other site 1179773003140 MoeB interaction surface [polypeptide binding]; other site 1179773003141 thiocarboxylated glycine; other site 1179773003142 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1179773003143 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1179773003144 dimer interface [polypeptide binding]; other site 1179773003145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773003146 catalytic residue [active] 1179773003147 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1179773003148 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773003149 NodB motif; other site 1179773003150 active site 1179773003151 catalytic site [active] 1179773003152 metal binding site [ion binding]; metal-binding site 1179773003153 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1179773003154 active site 1179773003155 catalytic motif [active] 1179773003156 Zn binding site [ion binding]; other site 1179773003157 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1179773003158 putative active site; other site 1179773003159 putative metal binding residues [ion binding]; other site 1179773003160 signature motif; other site 1179773003161 putative triphosphate binding site [ion binding]; other site 1179773003162 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1179773003163 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1179773003164 Rhomboid family; Region: Rhomboid; pfam01694 1179773003165 glutamate racemase; Provisional; Region: PRK00865 1179773003166 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1179773003167 OsmC-like protein; Region: OsmC; pfam02566 1179773003168 ribonuclease PH; Reviewed; Region: rph; PRK00173 1179773003169 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1179773003170 hexamer interface [polypeptide binding]; other site 1179773003171 active site 1179773003172 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1179773003173 active site 1179773003174 dimerization interface [polypeptide binding]; other site 1179773003175 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773003176 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1179773003177 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1179773003178 catalytic triad [active] 1179773003179 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1179773003180 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1179773003181 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1179773003182 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1179773003183 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1179773003184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773003185 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1179773003186 Putative sensor; Region: Sensor; pfam13796 1179773003187 Histidine kinase; Region: HisKA_3; pfam07730 1179773003188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773003189 Mg2+ binding site [ion binding]; other site 1179773003190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773003191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773003192 active site 1179773003193 phosphorylation site [posttranslational modification] 1179773003194 intermolecular recognition site; other site 1179773003195 dimerization interface [polypeptide binding]; other site 1179773003196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773003197 DNA binding residues [nucleotide binding] 1179773003198 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1179773003199 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1179773003200 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1179773003201 putative hydrophobic ligand binding site [chemical binding]; other site 1179773003202 protein interface [polypeptide binding]; other site 1179773003203 gate; other site 1179773003204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773003205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773003206 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1179773003207 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1179773003208 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1179773003209 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773003210 active site 1179773003211 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773003212 active site 1179773003213 metal binding site [ion binding]; metal-binding site 1179773003214 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1179773003215 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1179773003216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773003217 Cupin domain; Region: Cupin_2; pfam07883 1179773003218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773003219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773003220 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1179773003221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1179773003222 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1179773003223 catalytic triad [active] 1179773003224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773003225 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1179773003226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773003227 non-specific DNA binding site [nucleotide binding]; other site 1179773003228 salt bridge; other site 1179773003229 sequence-specific DNA binding site [nucleotide binding]; other site 1179773003230 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1179773003231 putative active site [active] 1179773003232 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773003233 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1179773003234 glycyl-tRNA synthetase; Provisional; Region: PRK14908 1179773003235 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1179773003236 dimer interface [polypeptide binding]; other site 1179773003237 motif 1; other site 1179773003238 active site 1179773003239 motif 2; other site 1179773003240 motif 3; other site 1179773003241 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773003242 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773003243 active site 1179773003244 catalytic residues [active] 1179773003245 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1179773003246 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1179773003247 putative ligand binding site [chemical binding]; other site 1179773003248 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773003249 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773003250 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1179773003251 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1179773003252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773003253 DNA-binding site [nucleotide binding]; DNA binding site 1179773003254 RNA-binding motif; other site 1179773003255 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773003256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773003257 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1179773003258 active site 1179773003259 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1179773003260 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 1179773003261 SWIM zinc finger; Region: SWIM; pfam04434 1179773003262 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1179773003263 SNF2 Helicase protein; Region: DUF3670; pfam12419 1179773003264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773003265 ATP binding site [chemical binding]; other site 1179773003266 putative Mg++ binding site [ion binding]; other site 1179773003267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773003268 nucleotide binding region [chemical binding]; other site 1179773003269 ATP-binding site [chemical binding]; other site 1179773003270 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1179773003271 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773003272 cofactor binding site; other site 1179773003273 DNA binding site [nucleotide binding] 1179773003274 substrate interaction site [chemical binding]; other site 1179773003275 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773003276 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1179773003277 additional DNA contacts [nucleotide binding]; other site 1179773003278 mismatch recognition site; other site 1179773003279 active site 1179773003280 zinc binding site [ion binding]; other site 1179773003281 DNA intercalation site [nucleotide binding]; other site 1179773003282 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1179773003283 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773003284 TIGR03086 family protein; Region: TIGR03086 1179773003285 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773003286 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1179773003287 Protein of unknown function DUF262; Region: DUF262; pfam03235 1179773003288 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1179773003289 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1179773003290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773003291 motif II; other site 1179773003292 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773003293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773003294 DNA-binding site [nucleotide binding]; DNA binding site 1179773003295 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773003296 Helix-turn-helix domain; Region: HTH_17; pfam12728 1179773003297 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1179773003298 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773003299 active site 1179773003300 DNA binding site [nucleotide binding] 1179773003301 Int/Topo IB signature motif; other site 1179773003302 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1179773003303 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1179773003304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1179773003305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773003306 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773003308 Walker A/P-loop; other site 1179773003309 ATP binding site [chemical binding]; other site 1179773003310 Q-loop/lid; other site 1179773003311 ABC transporter signature motif; other site 1179773003312 Walker B; other site 1179773003313 D-loop; other site 1179773003314 H-loop/switch region; other site 1179773003315 ABC transporter; Region: ABC_tran_2; pfam12848 1179773003316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773003317 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1179773003318 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1179773003319 catalytic site [active] 1179773003320 putative active site [active] 1179773003321 putative substrate binding site [chemical binding]; other site 1179773003322 dimer interface [polypeptide binding]; other site 1179773003323 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1179773003324 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1179773003325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773003326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773003327 putative substrate translocation pore; other site 1179773003328 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773003329 conserved cys residue [active] 1179773003330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773003332 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773003333 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773003334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773003335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773003336 non-specific DNA binding site [nucleotide binding]; other site 1179773003337 salt bridge; other site 1179773003338 sequence-specific DNA binding site [nucleotide binding]; other site 1179773003339 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773003340 DNA binding site [nucleotide binding] 1179773003341 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773003342 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773003343 Predicted membrane protein [Function unknown]; Region: COG3428 1179773003344 Bacterial PH domain; Region: DUF304; pfam03703 1179773003345 Bacterial PH domain; Region: DUF304; pfam03703 1179773003346 Bacterial PH domain; Region: DUF304; cl01348 1179773003347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773003348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773003349 DNA binding residues [nucleotide binding] 1179773003350 dimerization interface [polypeptide binding]; other site 1179773003351 acyl-CoA synthetase; Validated; Region: PRK07788 1179773003352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773003353 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1179773003354 acyl-activating enzyme (AAE) consensus motif; other site 1179773003355 putative AMP binding site [chemical binding]; other site 1179773003356 putative active site [active] 1179773003357 putative CoA binding site [chemical binding]; other site 1179773003358 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1179773003359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773003360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773003361 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773003362 MarR family; Region: MarR; pfam01047 1179773003363 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1179773003364 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773003365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773003366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773003367 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773003368 dimerization interface [polypeptide binding]; other site 1179773003369 substrate binding pocket [chemical binding]; other site 1179773003370 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1179773003371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773003372 TPR motif; other site 1179773003373 binding surface 1179773003374 TPR repeat; Region: TPR_11; pfam13414 1179773003375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773003376 TPR motif; other site 1179773003377 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1179773003378 Protein export membrane protein; Region: SecD_SecF; cl14618 1179773003379 Protein export membrane protein; Region: SecD_SecF; cl14618 1179773003380 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1179773003381 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1179773003382 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1179773003383 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1179773003384 putative active site [active] 1179773003385 putative substrate binding site [chemical binding]; other site 1179773003386 putative FMN binding site [chemical binding]; other site 1179773003387 putative catalytic residues [active] 1179773003388 EspG family; Region: ESX-1_EspG; pfam14011 1179773003389 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773003390 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1179773003391 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1179773003392 active site 1179773003393 catalytic triad [active] 1179773003394 dimer interface [polypeptide binding]; other site 1179773003395 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 1179773003396 active site 1179773003397 catalytic residues [active] 1179773003398 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1179773003399 metal binding site [ion binding]; metal-binding site 1179773003400 ligand binding site [chemical binding]; other site 1179773003401 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1179773003402 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1179773003403 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1179773003404 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1179773003405 active site 1179773003406 DNA binding site [nucleotide binding] 1179773003407 catalytic site [active] 1179773003408 Proline dehydrogenase; Region: Pro_dh; cl03282 1179773003409 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773003410 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1179773003411 NAD(P) binding site [chemical binding]; other site 1179773003412 catalytic residues [active] 1179773003413 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773003414 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1179773003415 putative di-iron ligands [ion binding]; other site 1179773003416 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1179773003417 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773003418 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1179773003419 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1179773003420 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773003421 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773003422 NAD(P) binding site [chemical binding]; other site 1179773003423 catalytic residues [active] 1179773003424 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1179773003425 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1179773003426 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1179773003427 active site 1179773003428 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1179773003429 putative active site; other site 1179773003430 putative metal binding residues [ion binding]; other site 1179773003431 signature motif; other site 1179773003432 putative triphosphate binding site [ion binding]; other site 1179773003433 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1179773003434 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1179773003435 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1179773003436 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1179773003437 active site 1179773003438 substrate binding site [chemical binding]; other site 1179773003439 cosubstrate binding site; other site 1179773003440 catalytic site [active] 1179773003441 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1179773003442 substrate binding site [chemical binding]; other site 1179773003443 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1179773003444 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1179773003445 active site 1179773003446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773003447 MarR family; Region: MarR_2; pfam12802 1179773003448 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773003449 putative active site [active] 1179773003450 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773003451 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773003452 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773003453 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1179773003454 putative metal binding site [ion binding]; other site 1179773003455 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1179773003456 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1179773003457 Immunity protein Imm1; Region: Imm1; pfam14430 1179773003458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773003459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773003460 DNA binding site [nucleotide binding] 1179773003461 domain linker motif; other site 1179773003462 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1179773003463 putative dimerization interface [polypeptide binding]; other site 1179773003464 putative ligand binding site [chemical binding]; other site 1179773003465 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1179773003466 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1179773003467 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1179773003468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773003469 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773003470 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773003471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773003472 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773003473 Walker A/P-loop; other site 1179773003474 ATP binding site [chemical binding]; other site 1179773003475 Q-loop/lid; other site 1179773003476 ABC transporter signature motif; other site 1179773003477 Walker B; other site 1179773003478 D-loop; other site 1179773003479 H-loop/switch region; other site 1179773003480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773003481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773003482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1179773003483 dimer interface [polypeptide binding]; other site 1179773003484 ssDNA binding site [nucleotide binding]; other site 1179773003485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1179773003486 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1179773003487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773003488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773003489 ABC transporter; Region: ABC_tran_2; pfam12848 1179773003490 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773003491 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1179773003492 YCII-related domain; Region: YCII; cl00999 1179773003493 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1179773003494 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773003495 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1179773003496 active site 1179773003497 catalytic site [active] 1179773003498 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1179773003499 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1179773003500 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1179773003501 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773003502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773003503 DNA binding site [nucleotide binding] 1179773003504 domain linker motif; other site 1179773003505 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773003506 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773003507 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1179773003508 active site 1179773003509 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1179773003510 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1179773003511 active site 1179773003512 catalytic site [active] 1179773003513 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1179773003514 apolar tunnel; other site 1179773003515 heme binding site [chemical binding]; other site 1179773003516 dimerization interface [polypeptide binding]; other site 1179773003517 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773003518 Integrase core domain; Region: rve; pfam00665 1179773003519 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773003520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773003521 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1179773003522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1179773003523 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1179773003524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773003525 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1179773003526 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1179773003527 active site 1179773003528 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1179773003529 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1179773003530 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773003531 Repair protein; Region: Repair_PSII; cl01535 1179773003532 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1179773003533 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1179773003534 Zn binding site [ion binding]; other site 1179773003535 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1179773003536 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773003537 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1179773003538 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773003539 NAD binding site [chemical binding]; other site 1179773003540 catalytic residues [active] 1179773003541 Predicted ATPase [General function prediction only]; Region: COG3903 1179773003542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773003543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773003544 DNA binding residues [nucleotide binding] 1179773003545 dimerization interface [polypeptide binding]; other site 1179773003546 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1179773003547 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1179773003548 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1179773003549 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1179773003550 putative DNA binding site [nucleotide binding]; other site 1179773003551 catalytic residue [active] 1179773003552 putative H2TH interface [polypeptide binding]; other site 1179773003553 putative catalytic residues [active] 1179773003554 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1179773003555 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1179773003556 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1179773003557 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773003558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773003559 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773003560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773003561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773003562 hypothetical protein; Provisional; Region: PRK01346 1179773003563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1179773003564 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1179773003565 nucleotide binding site/active site [active] 1179773003566 HIT family signature motif; other site 1179773003567 catalytic residue [active] 1179773003568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773003569 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773003570 active site 1179773003571 metal binding site [ion binding]; metal-binding site 1179773003572 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1179773003573 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1179773003574 nudix motif; other site 1179773003575 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773003576 Predicted transcriptional regulators [Transcription]; Region: COG1725 1179773003577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773003578 DNA-binding site [nucleotide binding]; DNA binding site 1179773003579 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1179773003580 DNA binding domain, excisionase family; Region: excise; TIGR01764 1179773003581 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1179773003582 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773003583 active site 1179773003584 catalytic residues [active] 1179773003585 DNA binding site [nucleotide binding] 1179773003586 Int/Topo IB signature motif; other site 1179773003587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773003588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773003589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773003590 dimerization interface [polypeptide binding]; other site 1179773003591 trigger factor; Provisional; Region: tig; PRK01490 1179773003592 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1179773003593 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1179773003594 Clp protease; Region: CLP_protease; pfam00574 1179773003595 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1179773003596 oligomer interface [polypeptide binding]; other site 1179773003597 active site residues [active] 1179773003598 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1179773003599 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1179773003600 oligomer interface [polypeptide binding]; other site 1179773003601 active site residues [active] 1179773003602 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1179773003603 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1179773003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773003605 Walker A motif; other site 1179773003606 ATP binding site [chemical binding]; other site 1179773003607 Walker B motif; other site 1179773003608 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1179773003609 Serine hydrolase; Region: Ser_hydrolase; cl17834 1179773003610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773003611 Predicted esterase [General function prediction only]; Region: COG0627 1179773003612 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1179773003613 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773003614 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1179773003615 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1179773003616 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1179773003617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773003618 dimerization interface [polypeptide binding]; other site 1179773003619 putative DNA binding site [nucleotide binding]; other site 1179773003620 putative Zn2+ binding site [ion binding]; other site 1179773003621 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1179773003622 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1179773003623 putative molybdopterin cofactor binding site [chemical binding]; other site 1179773003624 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1179773003625 putative molybdopterin cofactor binding site; other site 1179773003626 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1179773003627 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773003628 active site 1179773003629 HIGH motif; other site 1179773003630 nucleotide binding site [chemical binding]; other site 1179773003631 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1179773003632 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1179773003633 active site 1179773003634 KMSKS motif; other site 1179773003635 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1179773003636 tRNA binding surface [nucleotide binding]; other site 1179773003637 anticodon binding site; other site 1179773003638 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1179773003639 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1179773003640 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773003641 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1179773003642 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1179773003643 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773003644 putative active site [active] 1179773003645 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1179773003646 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1179773003647 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773003648 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1179773003649 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773003650 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773003651 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1179773003652 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1179773003653 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1179773003654 active site 1179773003655 catalytic site [active] 1179773003656 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1179773003657 carbohydrate binding site [chemical binding]; other site 1179773003658 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1179773003659 carbohydrate binding site [chemical binding]; other site 1179773003660 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1179773003661 active site 1179773003662 multimer interface [polypeptide binding]; other site 1179773003663 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773003664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1179773003665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773003667 Walker A/P-loop; other site 1179773003668 ATP binding site [chemical binding]; other site 1179773003669 Q-loop/lid; other site 1179773003670 ABC transporter signature motif; other site 1179773003671 Walker B; other site 1179773003672 D-loop; other site 1179773003673 H-loop/switch region; other site 1179773003674 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773003675 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773003676 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773003677 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773003678 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1179773003679 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1179773003680 B12 binding site [chemical binding]; other site 1179773003681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773003682 FeS/SAM binding site; other site 1179773003683 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773003684 active site 1179773003685 catalytic residues [active] 1179773003686 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1179773003687 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1179773003688 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1179773003689 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1179773003690 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1179773003691 homodimer interface [polypeptide binding]; other site 1179773003692 oligonucleotide binding site [chemical binding]; other site 1179773003693 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1179773003694 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1179773003695 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1179773003696 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1179773003697 GTP1/OBG; Region: GTP1_OBG; pfam01018 1179773003698 Obg GTPase; Region: Obg; cd01898 1179773003699 G1 box; other site 1179773003700 GTP/Mg2+ binding site [chemical binding]; other site 1179773003701 Switch I region; other site 1179773003702 G2 box; other site 1179773003703 G3 box; other site 1179773003704 Switch II region; other site 1179773003705 G4 box; other site 1179773003706 G5 box; other site 1179773003707 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1179773003708 gamma-glutamyl kinase; Provisional; Region: PRK05429 1179773003709 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1179773003710 nucleotide binding site [chemical binding]; other site 1179773003711 homotetrameric interface [polypeptide binding]; other site 1179773003712 putative phosphate binding site [ion binding]; other site 1179773003713 putative allosteric binding site; other site 1179773003714 PUA domain; Region: PUA; pfam01472 1179773003715 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1179773003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773003717 metabolite-proton symporter; Region: 2A0106; TIGR00883 1179773003718 putative substrate translocation pore; other site 1179773003719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773003720 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773003721 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1179773003722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773003723 ATP binding site [chemical binding]; other site 1179773003724 putative Mg++ binding site [ion binding]; other site 1179773003725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773003726 nucleotide binding region [chemical binding]; other site 1179773003727 ATP-binding site [chemical binding]; other site 1179773003728 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1179773003729 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1179773003730 putative catalytic cysteine [active] 1179773003731 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1179773003732 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1179773003733 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1179773003734 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1179773003735 active site 1179773003736 (T/H)XGH motif; other site 1179773003737 Oligomerisation domain; Region: Oligomerisation; cl00519 1179773003738 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773003739 catalytic core [active] 1179773003740 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1179773003741 active site 1179773003742 catalytic triad [active] 1179773003743 oxyanion hole [active] 1179773003744 EDD domain protein, DegV family; Region: DegV; TIGR00762 1179773003745 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1179773003746 SLBB domain; Region: SLBB; pfam10531 1179773003747 comEA protein; Region: comE; TIGR01259 1179773003748 Helix-hairpin-helix motif; Region: HHH; pfam00633 1179773003749 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1179773003750 Competence protein; Region: Competence; pfam03772 1179773003751 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1179773003752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773003753 threonine synthase; Validated; Region: PRK07591 1179773003754 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1179773003755 homodimer interface [polypeptide binding]; other site 1179773003756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773003757 catalytic residue [active] 1179773003758 hypothetical protein; Reviewed; Region: PRK07914 1179773003759 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1179773003760 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1179773003761 hypothetical protein; Provisional; Region: PRK10621 1179773003762 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1179773003763 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773003764 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773003765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1179773003766 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1179773003767 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1179773003768 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773003769 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773003770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773003771 Coenzyme A binding pocket [chemical binding]; other site 1179773003772 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1179773003773 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1179773003774 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773003775 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773003776 active site 1179773003777 PemK-like protein; Region: PemK; cl00995 1179773003778 GTP-binding protein LepA; Provisional; Region: PRK05433 1179773003779 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1179773003780 G1 box; other site 1179773003781 putative GEF interaction site [polypeptide binding]; other site 1179773003782 GTP/Mg2+ binding site [chemical binding]; other site 1179773003783 Switch I region; other site 1179773003784 G2 box; other site 1179773003785 G3 box; other site 1179773003786 Switch II region; other site 1179773003787 G4 box; other site 1179773003788 G5 box; other site 1179773003789 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1179773003790 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1179773003791 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1179773003792 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773003793 putative active site [active] 1179773003794 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773003795 putative active site [active] 1179773003796 HD domain; Region: HD_4; pfam13328 1179773003797 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1179773003798 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1179773003799 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1179773003800 putative active site [active] 1179773003801 PhoD-like phosphatase; Region: PhoD; pfam09423 1179773003802 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773003803 putative active site [active] 1179773003804 putative metal binding site [ion binding]; other site 1179773003805 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1179773003806 Nitronate monooxygenase; Region: NMO; pfam03060 1179773003807 FMN binding site [chemical binding]; other site 1179773003808 substrate binding site [chemical binding]; other site 1179773003809 putative catalytic residue [active] 1179773003810 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773003811 amino acid transporter; Region: 2A0306; TIGR00909 1179773003812 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1179773003813 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1179773003814 EamA-like transporter family; Region: EamA; pfam00892 1179773003815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773003816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773003817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773003818 dimerization interface [polypeptide binding]; other site 1179773003819 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773003820 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773003821 NAD(P) binding site [chemical binding]; other site 1179773003822 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1179773003823 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1179773003824 active site 1179773003825 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1179773003826 putative RNAase interaction site [polypeptide binding]; other site 1179773003827 enoyl-CoA hydratase; Provisional; Region: PRK07827 1179773003828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773003829 substrate binding site [chemical binding]; other site 1179773003830 oxyanion hole (OAH) forming residues; other site 1179773003831 trimer interface [polypeptide binding]; other site 1179773003832 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1179773003833 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1179773003834 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1179773003835 conserved cys residue [active] 1179773003836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773003837 MarR family; Region: MarR_2; pfam12802 1179773003838 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1179773003839 putative active site [active] 1179773003840 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1179773003841 active site 1179773003842 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773003843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773003844 dimer interface [polypeptide binding]; other site 1179773003845 conserved gate region; other site 1179773003846 putative PBP binding loops; other site 1179773003847 ABC-ATPase subunit interface; other site 1179773003848 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1179773003849 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773003850 Walker A/P-loop; other site 1179773003851 ATP binding site [chemical binding]; other site 1179773003852 Q-loop/lid; other site 1179773003853 ABC transporter signature motif; other site 1179773003854 Walker B; other site 1179773003855 D-loop; other site 1179773003856 H-loop/switch region; other site 1179773003857 NMT1-like family; Region: NMT1_2; pfam13379 1179773003858 NMT1/THI5 like; Region: NMT1; pfam09084 1179773003859 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1179773003860 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1179773003861 CysD dimerization site [polypeptide binding]; other site 1179773003862 G1 box; other site 1179773003863 putative GEF interaction site [polypeptide binding]; other site 1179773003864 GTP/Mg2+ binding site [chemical binding]; other site 1179773003865 Switch I region; other site 1179773003866 G2 box; other site 1179773003867 G3 box; other site 1179773003868 Switch II region; other site 1179773003869 G4 box; other site 1179773003870 G5 box; other site 1179773003871 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1179773003872 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1179773003873 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1179773003874 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1179773003875 Active Sites [active] 1179773003876 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1179773003877 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1179773003878 Active Sites [active] 1179773003879 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1179773003880 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1179773003881 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1179773003882 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1179773003883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773003884 FeS/SAM binding site; other site 1179773003885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773003886 Coenzyme A binding pocket [chemical binding]; other site 1179773003887 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1179773003888 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1179773003889 chaperone protein DnaJ; Provisional; Region: PRK14278 1179773003890 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1179773003891 HSP70 interaction site [polypeptide binding]; other site 1179773003892 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1179773003893 Zn binding sites [ion binding]; other site 1179773003894 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1179773003895 dimer interface [polypeptide binding]; other site 1179773003896 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1179773003897 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773003898 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773003899 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1179773003900 nucleotide binding site/active site [active] 1179773003901 HIT family signature motif; other site 1179773003902 catalytic residue [active] 1179773003903 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773003904 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773003905 Berberine and berberine like; Region: BBE; pfam08031 1179773003906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773003907 Coenzyme A binding pocket [chemical binding]; other site 1179773003908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773003909 PhoH-like protein; Region: PhoH; pfam02562 1179773003910 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1179773003911 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1179773003912 thioester formation/cholesterol transfer; other site 1179773003913 Homing endonuclease; Region: Hom_end; pfam05204 1179773003914 PhoH-like protein; Region: PhoH; pfam02562 1179773003915 metal-binding heat shock protein; Provisional; Region: PRK00016 1179773003916 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1179773003917 Domain of unknown function DUF21; Region: DUF21; pfam01595 1179773003918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1179773003919 Transporter associated domain; Region: CorC_HlyC; smart01091 1179773003920 GTPase Era; Reviewed; Region: era; PRK00089 1179773003921 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1179773003922 G1 box; other site 1179773003923 GTP/Mg2+ binding site [chemical binding]; other site 1179773003924 Switch I region; other site 1179773003925 G2 box; other site 1179773003926 Switch II region; other site 1179773003927 G3 box; other site 1179773003928 G4 box; other site 1179773003929 G5 box; other site 1179773003930 KH domain; Region: KH_2; pfam07650 1179773003931 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1179773003932 Recombination protein O N terminal; Region: RecO_N; pfam11967 1179773003933 Recombination protein O C terminal; Region: RecO_C; pfam02565 1179773003934 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1179773003935 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1179773003936 catalytic residue [active] 1179773003937 putative FPP diphosphate binding site; other site 1179773003938 putative FPP binding hydrophobic cleft; other site 1179773003939 dimer interface [polypeptide binding]; other site 1179773003940 putative IPP diphosphate binding site; other site 1179773003941 Predicted permease; Region: DUF318; cl17795 1179773003942 TIGR03943 family protein; Region: TIGR03943 1179773003943 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1179773003944 metal binding site 2 [ion binding]; metal-binding site 1179773003945 putative DNA binding helix; other site 1179773003946 metal binding site 1 [ion binding]; metal-binding site 1179773003947 dimer interface [polypeptide binding]; other site 1179773003948 structural Zn2+ binding site [ion binding]; other site 1179773003949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773003950 dimerization interface [polypeptide binding]; other site 1179773003951 putative DNA binding site [nucleotide binding]; other site 1179773003952 putative Zn2+ binding site [ion binding]; other site 1179773003953 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1179773003954 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1179773003955 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773003956 motif 1; other site 1179773003957 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1179773003958 dimer interface [polypeptide binding]; other site 1179773003959 active site 1179773003960 motif 2; other site 1179773003961 motif 3; other site 1179773003962 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1179773003963 anticodon binding site; other site 1179773003964 Cupin; Region: Cupin_6; pfam12852 1179773003965 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1179773003966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773003967 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1179773003968 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1179773003969 active site clefts [active] 1179773003970 zinc binding site [ion binding]; other site 1179773003971 dimer interface [polypeptide binding]; other site 1179773003972 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773003973 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1179773003974 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1179773003975 active site pocket [active] 1179773003976 oxyanion hole [active] 1179773003977 catalytic triad [active] 1179773003978 active site nucleophile [active] 1179773003979 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1179773003980 putative active site [active] 1179773003981 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1179773003982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1179773003983 Zn2+ binding site [ion binding]; other site 1179773003984 Mg2+ binding site [ion binding]; other site 1179773003985 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1179773003986 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 1179773003987 reactive center loop; other site 1179773003988 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1179773003989 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1179773003990 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 1179773003991 active site 1179773003992 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1179773003993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773003994 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773003995 DNA primase; Validated; Region: dnaG; PRK05667 1179773003996 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1179773003997 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1179773003998 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1179773003999 active site 1179773004000 metal binding site [ion binding]; metal-binding site 1179773004001 interdomain interaction site; other site 1179773004002 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1179773004003 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1179773004004 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1179773004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773004006 S-adenosylmethionine binding site [chemical binding]; other site 1179773004007 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1179773004008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773004009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773004010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773004011 ligand binding site [chemical binding]; other site 1179773004012 flexible hinge region; other site 1179773004013 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773004014 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773004015 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1179773004016 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773004017 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1179773004018 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773004019 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1179773004020 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773004021 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773004022 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1179773004023 DXD motif; other site 1179773004024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773004025 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1179773004026 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1179773004027 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1179773004028 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1179773004029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773004030 Cytochrome P450; Region: p450; cl12078 1179773004031 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773004032 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773004033 Walker A/P-loop; other site 1179773004034 ATP binding site [chemical binding]; other site 1179773004035 Q-loop/lid; other site 1179773004036 ABC transporter signature motif; other site 1179773004037 Walker B; other site 1179773004038 D-loop; other site 1179773004039 H-loop/switch region; other site 1179773004040 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773004041 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773004042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773004043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773004044 non-specific DNA binding site [nucleotide binding]; other site 1179773004045 salt bridge; other site 1179773004046 sequence-specific DNA binding site [nucleotide binding]; other site 1179773004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773004048 hypothetical protein; Provisional; Region: PRK06753 1179773004049 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773004050 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1179773004051 active site 1179773004052 dimer interface [polypeptide binding]; other site 1179773004053 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1179773004054 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1179773004055 ligand binding site [chemical binding]; other site 1179773004056 homodimer interface [polypeptide binding]; other site 1179773004057 NAD(P) binding site [chemical binding]; other site 1179773004058 trimer interface B [polypeptide binding]; other site 1179773004059 trimer interface A [polypeptide binding]; other site 1179773004060 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1179773004061 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1179773004062 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1179773004063 PAS domain S-box; Region: sensory_box; TIGR00229 1179773004064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773004065 putative active site [active] 1179773004066 heme pocket [chemical binding]; other site 1179773004067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773004068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773004069 metal binding site [ion binding]; metal-binding site 1179773004070 active site 1179773004071 I-site; other site 1179773004072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1179773004073 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773004074 MarR family; Region: MarR; pfam01047 1179773004075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773004076 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1179773004077 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1179773004078 Part of AAA domain; Region: AAA_19; pfam13245 1179773004079 Family description; Region: UvrD_C_2; pfam13538 1179773004080 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773004081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773004082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773004083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773004084 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1179773004085 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773004086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773004087 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773004088 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1179773004089 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1179773004090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773004091 Walker A/P-loop; other site 1179773004092 ATP binding site [chemical binding]; other site 1179773004093 Q-loop/lid; other site 1179773004094 ABC transporter signature motif; other site 1179773004095 Walker B; other site 1179773004096 D-loop; other site 1179773004097 H-loop/switch region; other site 1179773004098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773004099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773004100 Walker A/P-loop; other site 1179773004101 ATP binding site [chemical binding]; other site 1179773004102 ABC transporter; Region: ABC_tran; pfam00005 1179773004103 Q-loop/lid; other site 1179773004104 ABC transporter signature motif; other site 1179773004105 Walker B; other site 1179773004106 D-loop; other site 1179773004107 H-loop/switch region; other site 1179773004108 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1179773004109 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773004110 active site 1179773004111 ATP binding site [chemical binding]; other site 1179773004112 substrate binding site [chemical binding]; other site 1179773004113 activation loop (A-loop); other site 1179773004114 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1179773004115 active site 1179773004116 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1179773004117 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773004118 dimer interface [polypeptide binding]; other site 1179773004119 active site 1179773004120 acyl carrier protein; Provisional; Region: acpP; PRK00982 1179773004121 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1179773004122 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1179773004123 dimer interface [polypeptide binding]; other site 1179773004124 active site 1179773004125 CoA binding pocket [chemical binding]; other site 1179773004126 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1179773004127 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773004128 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773004129 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773004130 Conserved TM helix; Region: TM_helix; pfam05552 1179773004131 Phytase; Region: Phytase; cl17685 1179773004132 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1179773004133 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1179773004134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773004135 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1179773004136 nucleotidyl binding site; other site 1179773004137 metal binding site [ion binding]; metal-binding site 1179773004138 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1179773004139 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1179773004140 dimer interface [polypeptide binding]; other site 1179773004141 TPP-binding site [chemical binding]; other site 1179773004142 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1179773004143 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1179773004144 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1179773004145 dimer interface [polypeptide binding]; other site 1179773004146 catalytic triad [active] 1179773004147 lipoyl synthase; Provisional; Region: PRK05481 1179773004148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773004149 FeS/SAM binding site; other site 1179773004150 short chain dehydrogenase; Provisional; Region: PRK06197 1179773004151 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1179773004152 putative NAD(P) binding site [chemical binding]; other site 1179773004153 active site 1179773004154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773004155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773004156 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1179773004157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773004158 lipoate-protein ligase B; Provisional; Region: PRK14345 1179773004159 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1179773004160 active site 1179773004161 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1179773004162 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1179773004163 putative NAD(P) binding site [chemical binding]; other site 1179773004164 putative active site [active] 1179773004165 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1179773004166 E3 interaction surface; other site 1179773004167 lipoyl attachment site [posttranslational modification]; other site 1179773004168 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1179773004169 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1179773004170 E3 interaction surface; other site 1179773004171 lipoyl attachment site [posttranslational modification]; other site 1179773004172 e3 binding domain; Region: E3_binding; pfam02817 1179773004173 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1179773004174 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1179773004175 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1179773004176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773004177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773004178 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1179773004179 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1179773004180 interface (dimer of trimers) [polypeptide binding]; other site 1179773004181 Substrate-binding/catalytic site; other site 1179773004182 Zn-binding sites [ion binding]; other site 1179773004183 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1179773004184 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1179773004185 homodimer interface [polypeptide binding]; other site 1179773004186 substrate-cofactor binding pocket; other site 1179773004187 catalytic residue [active] 1179773004188 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1179773004189 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1179773004190 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1179773004191 putative dimer interface [polypeptide binding]; other site 1179773004192 active site pocket [active] 1179773004193 putative cataytic base [active] 1179773004194 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1179773004195 homotrimer interface [polypeptide binding]; other site 1179773004196 Walker A motif; other site 1179773004197 GTP binding site [chemical binding]; other site 1179773004198 Walker B motif; other site 1179773004199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773004200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773004201 active site 1179773004202 catalytic tetrad [active] 1179773004203 Immunity protein Imm1; Region: Imm1; pfam14430 1179773004204 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 1179773004205 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1179773004206 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1179773004207 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1179773004208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773004209 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773004210 putative substrate translocation pore; other site 1179773004211 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773004212 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773004213 DNA binding residues [nucleotide binding] 1179773004214 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1179773004215 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1179773004216 active site 1179773004217 dimer interface [polypeptide binding]; other site 1179773004218 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1179773004219 Ligand Binding Site [chemical binding]; other site 1179773004220 Molecular Tunnel; other site 1179773004221 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1179773004222 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1179773004223 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1179773004224 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773004225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773004226 putative acyl-acceptor binding pocket; other site 1179773004227 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773004228 nudix motif; other site 1179773004229 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1179773004230 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1179773004231 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1179773004232 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1179773004233 Subunit I/III interface [polypeptide binding]; other site 1179773004234 Cytochrome c; Region: Cytochrom_C; cl11414 1179773004235 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1179773004236 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1179773004237 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1179773004238 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1179773004239 iron-sulfur cluster [ion binding]; other site 1179773004240 [2Fe-2S] cluster binding site [ion binding]; other site 1179773004241 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1179773004242 heme bH binding site [chemical binding]; other site 1179773004243 intrachain domain interface; other site 1179773004244 heme bL binding site [chemical binding]; other site 1179773004245 interchain domain interface [polypeptide binding]; other site 1179773004246 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1179773004247 Qo binding site; other site 1179773004248 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773004249 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773004250 hypothetical protein; Validated; Region: PRK07883 1179773004251 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1179773004252 active site 1179773004253 catalytic site [active] 1179773004254 substrate binding site [chemical binding]; other site 1179773004255 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1179773004256 GIY-YIG motif/motif A; other site 1179773004257 active site 1179773004258 catalytic site [active] 1179773004259 putative DNA binding site [nucleotide binding]; other site 1179773004260 metal binding site [ion binding]; metal-binding site 1179773004261 YacP-like NYN domain; Region: NYN_YacP; cl01491 1179773004262 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773004263 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773004264 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1179773004265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773004266 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773004267 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773004268 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773004269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773004270 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1179773004271 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1179773004272 acyl-activating enzyme (AAE) consensus motif; other site 1179773004273 putative AMP binding site [chemical binding]; other site 1179773004274 putative active site [active] 1179773004275 putative CoA binding site [chemical binding]; other site 1179773004276 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773004277 active site 1179773004278 metal binding site [ion binding]; metal-binding site 1179773004279 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1179773004280 putative hydrophobic ligand binding site [chemical binding]; other site 1179773004281 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1179773004282 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1179773004283 P loop; other site 1179773004284 Nucleotide binding site [chemical binding]; other site 1179773004285 DTAP/Switch II; other site 1179773004286 Switch I; other site 1179773004287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773004288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773004289 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773004290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773004291 putative acyl-acceptor binding pocket; other site 1179773004292 phosphofructokinase; Region: PFK_mixed; TIGR02483 1179773004293 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1179773004294 active site 1179773004295 ADP/pyrophosphate binding site [chemical binding]; other site 1179773004296 dimerization interface [polypeptide binding]; other site 1179773004297 allosteric effector site; other site 1179773004298 fructose-1,6-bisphosphate binding site; other site 1179773004299 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1179773004300 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773004301 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773004302 active site 1179773004303 ATP binding site [chemical binding]; other site 1179773004304 substrate binding site [chemical binding]; other site 1179773004305 activation loop (A-loop); other site 1179773004306 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773004307 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773004308 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773004309 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1179773004310 RNA polymerase sigma factor; Provisional; Region: PRK12525 1179773004311 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1179773004312 active site lid residues [active] 1179773004313 substrate binding pocket [chemical binding]; other site 1179773004314 catalytic residues [active] 1179773004315 substrate-Mg2+ binding site; other site 1179773004316 aspartate-rich region 1; other site 1179773004317 aspartate-rich region 2; other site 1179773004318 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1179773004319 phytoene desaturase; Region: crtI_fam; TIGR02734 1179773004320 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1179773004321 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1179773004322 substrate binding pocket [chemical binding]; other site 1179773004323 chain length determination region; other site 1179773004324 substrate-Mg2+ binding site; other site 1179773004325 catalytic residues [active] 1179773004326 aspartate-rich region 1; other site 1179773004327 active site lid residues [active] 1179773004328 aspartate-rich region 2; other site 1179773004329 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1179773004330 FAD binding site [chemical binding]; other site 1179773004331 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1179773004332 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1179773004333 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1179773004334 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773004335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773004336 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1179773004337 putative deacylase active site [active] 1179773004338 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773004339 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773004340 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1179773004341 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773004342 putative active site [active] 1179773004343 putative metal binding site [ion binding]; other site 1179773004344 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773004345 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773004346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773004347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773004348 DNA binding residues [nucleotide binding] 1179773004349 dimerization interface [polypeptide binding]; other site 1179773004350 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1179773004351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773004352 DNA-binding site [nucleotide binding]; DNA binding site 1179773004353 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1179773004354 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1179773004355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773004356 catalytic residue [active] 1179773004357 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1179773004358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773004359 ATP binding site [chemical binding]; other site 1179773004360 putative Mg++ binding site [ion binding]; other site 1179773004361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773004362 nucleotide binding region [chemical binding]; other site 1179773004363 ATP-binding site [chemical binding]; other site 1179773004364 DEAD/H associated; Region: DEAD_assoc; pfam08494 1179773004365 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773004366 nucleotide binding site [chemical binding]; other site 1179773004367 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773004368 SBD interface [polypeptide binding]; other site 1179773004369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1179773004370 putative substrate translocation pore; other site 1179773004371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773004372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773004373 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773004374 dimerization interface [polypeptide binding]; other site 1179773004375 substrate binding pocket [chemical binding]; other site 1179773004376 Cupin domain; Region: Cupin_2; pfam07883 1179773004377 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1179773004378 recombinase A; Provisional; Region: recA; PRK09354 1179773004379 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1179773004380 hexamer interface [polypeptide binding]; other site 1179773004381 Walker A motif; other site 1179773004382 ATP binding site [chemical binding]; other site 1179773004383 Walker B motif; other site 1179773004384 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1179773004385 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1179773004386 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1179773004387 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1179773004388 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1179773004389 active site 1179773004390 intersubunit interface [polypeptide binding]; other site 1179773004391 catalytic residue [active] 1179773004392 phosphogluconate dehydratase; Validated; Region: PRK09054 1179773004393 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1179773004394 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1179773004395 L-aspartate oxidase; Provisional; Region: PRK06175 1179773004396 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1179773004397 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1179773004398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1179773004399 catalytic loop [active] 1179773004400 iron binding site [ion binding]; other site 1179773004401 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773004402 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 1179773004403 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 1179773004404 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1179773004405 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1179773004406 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1179773004407 active site 1179773004408 dimer interface [polypeptide binding]; other site 1179773004409 effector binding site; other site 1179773004410 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1179773004411 TSCPD domain; Region: TSCPD; pfam12637 1179773004412 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1179773004413 ATP cone domain; Region: ATP-cone; pfam03477 1179773004414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773004415 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1179773004416 LexA repressor; Validated; Region: PRK00215 1179773004417 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1179773004418 Catalytic site [active] 1179773004419 GTPases [General function prediction only]; Region: HflX; COG2262 1179773004420 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1179773004421 HflX GTPase family; Region: HflX; cd01878 1179773004422 G1 box; other site 1179773004423 GTP/Mg2+ binding site [chemical binding]; other site 1179773004424 Switch I region; other site 1179773004425 G2 box; other site 1179773004426 G3 box; other site 1179773004427 Switch II region; other site 1179773004428 G4 box; other site 1179773004429 G5 box; other site 1179773004430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773004431 putative DNA binding site [nucleotide binding]; other site 1179773004432 putative Zn2+ binding site [ion binding]; other site 1179773004433 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773004434 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1179773004435 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1179773004436 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1179773004437 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1179773004438 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1179773004439 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1179773004440 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1179773004441 active site 1179773004442 metal binding site [ion binding]; metal-binding site 1179773004443 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1179773004444 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1179773004445 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1179773004446 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1179773004447 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1179773004448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773004449 FeS/SAM binding site; other site 1179773004450 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1179773004451 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1179773004452 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1179773004453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773004454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773004455 dimer interface [polypeptide binding]; other site 1179773004456 phosphorylation site [posttranslational modification] 1179773004457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773004458 ATP binding site [chemical binding]; other site 1179773004459 Mg2+ binding site [ion binding]; other site 1179773004460 G-X-G motif; other site 1179773004461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773004462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1179773004463 active site 1179773004464 phosphorylation site [posttranslational modification] 1179773004465 intermolecular recognition site; other site 1179773004466 dimerization interface [polypeptide binding]; other site 1179773004467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773004468 DNA binding site [nucleotide binding] 1179773004469 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773004470 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1179773004471 Walker A/P-loop; other site 1179773004472 ATP binding site [chemical binding]; other site 1179773004473 Q-loop/lid; other site 1179773004474 ABC transporter signature motif; other site 1179773004475 Walker B; other site 1179773004476 D-loop; other site 1179773004477 H-loop/switch region; other site 1179773004478 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773004479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773004480 substrate binding pocket [chemical binding]; other site 1179773004481 membrane-bound complex binding site; other site 1179773004482 hinge residues; other site 1179773004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773004484 dimer interface [polypeptide binding]; other site 1179773004485 conserved gate region; other site 1179773004486 putative PBP binding loops; other site 1179773004487 ABC-ATPase subunit interface; other site 1179773004488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773004489 dimer interface [polypeptide binding]; other site 1179773004490 conserved gate region; other site 1179773004491 putative PBP binding loops; other site 1179773004492 ABC-ATPase subunit interface; other site 1179773004493 EcsC protein family; Region: EcsC; pfam12787 1179773004494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773004495 FOG: CBS domain [General function prediction only]; Region: COG0517 1179773004496 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1179773004497 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1179773004498 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773004499 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1179773004500 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773004501 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1179773004502 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773004503 hydrophobic ligand binding site; other site 1179773004504 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773004506 putative substrate translocation pore; other site 1179773004507 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1179773004508 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1179773004509 Active_site [active] 1179773004510 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1179773004511 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1179773004512 NAD binding site [chemical binding]; other site 1179773004513 sugar binding site [chemical binding]; other site 1179773004514 divalent metal binding site [ion binding]; other site 1179773004515 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1179773004516 dimer interface [polypeptide binding]; other site 1179773004517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773004518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773004519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773004520 dimerization interface [polypeptide binding]; other site 1179773004521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773004522 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773004523 substrate binding pocket [chemical binding]; other site 1179773004524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773004525 MFS transport protein AraJ; Provisional; Region: PRK10091 1179773004526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773004527 putative substrate translocation pore; other site 1179773004528 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1179773004529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773004530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1179773004531 Peptidase family M23; Region: Peptidase_M23; pfam01551 1179773004532 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1179773004533 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1179773004534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773004535 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773004536 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1179773004537 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1179773004538 NAD binding site [chemical binding]; other site 1179773004539 homodimer interface [polypeptide binding]; other site 1179773004540 active site 1179773004541 substrate binding site [chemical binding]; other site 1179773004542 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1179773004543 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1179773004544 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1179773004545 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1179773004546 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1179773004547 non-specific DNA interactions [nucleotide binding]; other site 1179773004548 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1179773004549 DNA binding site [nucleotide binding] 1179773004550 sequence specific DNA binding site [nucleotide binding]; other site 1179773004551 putative cAMP binding site [chemical binding]; other site 1179773004552 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1179773004553 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1179773004554 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1179773004555 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1179773004556 active site residue [active] 1179773004557 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1179773004558 active site residue [active] 1179773004559 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1179773004560 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1179773004561 active site 1179773004562 Zn binding site [ion binding]; other site 1179773004563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773004564 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1179773004565 CoA binding domain; Region: CoA_binding_2; pfam13380 1179773004566 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1179773004567 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1179773004568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773004569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773004570 substrate binding pocket [chemical binding]; other site 1179773004571 membrane-bound complex binding site; other site 1179773004572 hinge residues; other site 1179773004573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773004574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773004575 DNA-binding site [nucleotide binding]; DNA binding site 1179773004576 UTRA domain; Region: UTRA; pfam07702 1179773004577 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1179773004578 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1179773004579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773004580 motif II; other site 1179773004581 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1179773004582 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1179773004583 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1179773004584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773004585 Walker A/P-loop; other site 1179773004586 ATP binding site [chemical binding]; other site 1179773004587 Q-loop/lid; other site 1179773004588 ABC transporter signature motif; other site 1179773004589 Walker B; other site 1179773004590 D-loop; other site 1179773004591 H-loop/switch region; other site 1179773004592 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1179773004593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773004594 dimer interface [polypeptide binding]; other site 1179773004595 conserved gate region; other site 1179773004596 putative PBP binding loops; other site 1179773004597 ABC-ATPase subunit interface; other site 1179773004598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773004599 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1179773004600 hypothetical protein; Reviewed; Region: PRK09588 1179773004601 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773004602 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773004603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773004604 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773004605 Walker A/P-loop; other site 1179773004606 ATP binding site [chemical binding]; other site 1179773004607 Q-loop/lid; other site 1179773004608 ABC transporter signature motif; other site 1179773004609 Walker B; other site 1179773004610 D-loop; other site 1179773004611 H-loop/switch region; other site 1179773004612 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773004613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773004614 AAA domain; Region: AAA_23; pfam13476 1179773004615 Walker A/P-loop; other site 1179773004616 ATP binding site [chemical binding]; other site 1179773004617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773004618 non-specific DNA binding site [nucleotide binding]; other site 1179773004619 salt bridge; other site 1179773004620 sequence-specific DNA binding site [nucleotide binding]; other site 1179773004621 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773004622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773004623 dimerization interface [polypeptide binding]; other site 1179773004624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773004625 dimer interface [polypeptide binding]; other site 1179773004626 phosphorylation site [posttranslational modification] 1179773004627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773004628 ATP binding site [chemical binding]; other site 1179773004629 Mg2+ binding site [ion binding]; other site 1179773004630 G-X-G motif; other site 1179773004631 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1179773004632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773004633 active site 1179773004634 phosphorylation site [posttranslational modification] 1179773004635 intermolecular recognition site; other site 1179773004636 dimerization interface [polypeptide binding]; other site 1179773004637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773004638 DNA binding site [nucleotide binding] 1179773004639 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773004640 HlyD family secretion protein; Region: HlyD_2; pfam12700 1179773004641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773004642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773004643 Walker A/P-loop; other site 1179773004644 ATP binding site [chemical binding]; other site 1179773004645 Q-loop/lid; other site 1179773004646 ABC transporter signature motif; other site 1179773004647 Walker B; other site 1179773004648 D-loop; other site 1179773004649 H-loop/switch region; other site 1179773004650 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773004651 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1179773004652 FtsX-like permease family; Region: FtsX; pfam02687 1179773004653 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1179773004654 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773004655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773004656 DNA-binding site [nucleotide binding]; DNA binding site 1179773004657 FCD domain; Region: FCD; pfam07729 1179773004658 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773004659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773004660 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773004661 fumarate hydratase; Provisional; Region: PRK15389 1179773004662 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1179773004663 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1179773004664 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1179773004665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773004666 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1179773004667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773004668 DNA binding residues [nucleotide binding] 1179773004669 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1179773004670 dimerization interface [polypeptide binding]; other site 1179773004671 putative tRNAtyr binding site [nucleotide binding]; other site 1179773004672 putative active site [active] 1179773004673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773004674 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1179773004675 S-adenosylmethionine binding site [chemical binding]; other site 1179773004676 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773004677 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1179773004678 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1179773004679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773004680 substrate binding site [chemical binding]; other site 1179773004681 ATP binding site [chemical binding]; other site 1179773004682 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1179773004683 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1179773004684 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1179773004685 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773004686 DNA binding residues [nucleotide binding] 1179773004687 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773004688 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773004689 DNA binding residues [nucleotide binding] 1179773004690 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1179773004691 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1179773004692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773004693 ATP binding site [chemical binding]; other site 1179773004694 putative Mg++ binding site [ion binding]; other site 1179773004695 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1179773004696 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1179773004697 putative ligand binding site [chemical binding]; other site 1179773004698 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1179773004699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1179773004700 Walker A/P-loop; other site 1179773004701 ATP binding site [chemical binding]; other site 1179773004702 Q-loop/lid; other site 1179773004703 ABC transporter signature motif; other site 1179773004704 Walker B; other site 1179773004705 D-loop; other site 1179773004706 H-loop/switch region; other site 1179773004707 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1179773004708 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1179773004709 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773004710 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1179773004711 TM-ABC transporter signature motif; other site 1179773004712 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773004713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773004714 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1179773004715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773004716 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1179773004717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773004718 DNA binding residues [nucleotide binding] 1179773004719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773004720 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773004721 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1179773004722 active site 1179773004723 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1179773004724 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1179773004725 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1179773004726 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1179773004727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1179773004728 trimer interface [polypeptide binding]; other site 1179773004729 active site 1179773004730 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1179773004731 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773004732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773004733 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1179773004734 generic binding surface II; other site 1179773004735 ssDNA binding site; other site 1179773004736 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1179773004737 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773004738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773004739 sequence-specific DNA binding site [nucleotide binding]; other site 1179773004740 salt bridge; other site 1179773004741 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1179773004742 TrkA-N domain; Region: TrkA_N; pfam02254 1179773004743 TrkA-C domain; Region: TrkA_C; pfam02080 1179773004744 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1179773004745 TrkA-N domain; Region: TrkA_N; pfam02254 1179773004746 TrkA-C domain; Region: TrkA_C; pfam02080 1179773004747 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1179773004748 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1179773004749 TRAM domain; Region: TRAM; pfam01938 1179773004750 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1179773004751 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1179773004752 TPP-binding site; other site 1179773004753 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1179773004754 PYR/PP interface [polypeptide binding]; other site 1179773004755 dimer interface [polypeptide binding]; other site 1179773004756 TPP binding site [chemical binding]; other site 1179773004757 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773004758 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1179773004759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773004761 active site 1179773004762 phosphorylation site [posttranslational modification] 1179773004763 intermolecular recognition site; other site 1179773004764 dimerization interface [polypeptide binding]; other site 1179773004765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773004766 DNA binding site [nucleotide binding] 1179773004767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773004768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773004769 dimerization interface [polypeptide binding]; other site 1179773004770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773004771 dimer interface [polypeptide binding]; other site 1179773004772 phosphorylation site [posttranslational modification] 1179773004773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773004774 ATP binding site [chemical binding]; other site 1179773004775 Mg2+ binding site [ion binding]; other site 1179773004776 G-X-G motif; other site 1179773004777 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1179773004778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773004779 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1179773004780 oligomer interface [polypeptide binding]; other site 1179773004781 homodimer interface [polypeptide binding]; other site 1179773004782 chemical substrate binding site [chemical binding]; other site 1179773004783 metal binding site [ion binding]; metal-binding site 1179773004784 Cupin; Region: Cupin_6; pfam12852 1179773004785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773004786 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773004787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773004788 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773004789 NAD(P) binding site [chemical binding]; other site 1179773004790 active site 1179773004791 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773004792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773004793 S-adenosylmethionine binding site [chemical binding]; other site 1179773004794 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1179773004795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773004796 ATP binding site [chemical binding]; other site 1179773004797 putative Mg++ binding site [ion binding]; other site 1179773004798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773004799 ATP-binding site [chemical binding]; other site 1179773004800 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1179773004801 AAA ATPase domain; Region: AAA_16; pfam13191 1179773004802 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1179773004803 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1179773004804 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773004805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773004806 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773004807 non-specific DNA binding site [nucleotide binding]; other site 1179773004808 salt bridge; other site 1179773004809 sequence-specific DNA binding site [nucleotide binding]; other site 1179773004810 EspG family; Region: ESX-1_EspG; pfam14011 1179773004811 PPE family; Region: PPE; pfam00823 1179773004812 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1179773004813 Nuclease-related domain; Region: NERD; pfam08378 1179773004814 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1179773004815 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773004816 active site 1179773004817 ATP binding site [chemical binding]; other site 1179773004818 substrate binding site [chemical binding]; other site 1179773004819 activation loop (A-loop); other site 1179773004820 Protein kinase domain; Region: Pkinase; pfam00069 1179773004821 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773004822 active site 1179773004823 ATP binding site [chemical binding]; other site 1179773004824 substrate binding site [chemical binding]; other site 1179773004825 activation loop (A-loop); other site 1179773004826 Caspase domain; Region: Peptidase_C14; pfam00656 1179773004827 Part of AAA domain; Region: AAA_19; pfam13245 1179773004828 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1179773004829 AAA domain; Region: AAA_12; pfam13087 1179773004830 Protein of unknown function DUF72; Region: DUF72; pfam01904 1179773004831 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1179773004832 Protein of unknown function DUF72; Region: DUF72; pfam01904 1179773004833 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1179773004834 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1179773004835 oligomeric interface; other site 1179773004836 putative active site [active] 1179773004837 homodimer interface [polypeptide binding]; other site 1179773004838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773004839 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1179773004840 substrate binding site [chemical binding]; other site 1179773004841 oxyanion hole (OAH) forming residues; other site 1179773004842 trimer interface [polypeptide binding]; other site 1179773004843 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773004844 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773004845 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1179773004846 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773004847 dimer interface [polypeptide binding]; other site 1179773004848 active site 1179773004849 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1179773004850 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 1179773004851 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773004852 DNA binding residues [nucleotide binding] 1179773004853 putative dimer interface [polypeptide binding]; other site 1179773004854 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1179773004855 catalytic site [active] 1179773004856 putative active site [active] 1179773004857 putative substrate binding site [chemical binding]; other site 1179773004858 HRDC domain; Region: HRDC; pfam00570 1179773004859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773004860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773004861 active site 1179773004862 phosphorylation site [posttranslational modification] 1179773004863 intermolecular recognition site; other site 1179773004864 dimerization interface [polypeptide binding]; other site 1179773004865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773004866 DNA binding residues [nucleotide binding] 1179773004867 dimerization interface [polypeptide binding]; other site 1179773004868 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1179773004869 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1179773004870 active site 1179773004871 dimer interface [polypeptide binding]; other site 1179773004872 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1179773004873 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1179773004874 substrate binding site [chemical binding]; other site 1179773004875 active site 1179773004876 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1179773004877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773004878 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1179773004879 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773004880 active site 1179773004881 catalytic residues [active] 1179773004882 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1179773004883 active site 1179773004884 catalytic triad [active] 1179773004885 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1179773004886 hypothetical protein; Provisional; Region: PRK05409 1179773004887 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1179773004888 TIGR04222 domain; Region: near_uncomplex 1179773004889 TIGR04222 domain; Region: near_uncomplex 1179773004890 TIGR04222 domain; Region: near_uncomplex 1179773004891 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1179773004892 SelR domain; Region: SelR; pfam01641 1179773004893 L-asparaginase II; Region: Asparaginase_II; pfam06089 1179773004894 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1179773004895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773004896 DNA-binding site [nucleotide binding]; DNA binding site 1179773004897 FCD domain; Region: FCD; pfam07729 1179773004898 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773004899 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773004900 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773004901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773004902 active site 1179773004903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773004904 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773004905 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1179773004906 nucleotide binding site [chemical binding]; other site 1179773004907 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773004908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773004909 active site 1179773004910 ATP binding site [chemical binding]; other site 1179773004911 substrate binding site [chemical binding]; other site 1179773004912 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773004913 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1179773004914 EamA-like transporter family; Region: EamA; pfam00892 1179773004915 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1179773004916 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1179773004917 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1179773004918 active site 1179773004919 DNA binding site [nucleotide binding] 1179773004920 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1179773004921 DNA binding site [nucleotide binding] 1179773004922 Asp23 family; Region: Asp23; pfam03780 1179773004923 Asp23 family; Region: Asp23; pfam03780 1179773004924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773004925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773004926 hypothetical protein; Provisional; Region: PRK14059 1179773004927 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1179773004928 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1179773004929 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1179773004930 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773004931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773004932 Walker A/P-loop; other site 1179773004933 ATP binding site [chemical binding]; other site 1179773004934 Q-loop/lid; other site 1179773004935 ABC transporter signature motif; other site 1179773004936 Walker B; other site 1179773004937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773004938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773004939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1179773004940 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1179773004941 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1179773004942 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773004943 inhibitor-cofactor binding pocket; inhibition site 1179773004944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773004945 catalytic residue [active] 1179773004946 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1179773004947 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1179773004948 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773004949 active site 1179773004950 catalytic triad [active] 1179773004951 oxyanion hole [active] 1179773004952 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1179773004953 putative hydrophobic ligand binding site [chemical binding]; other site 1179773004954 CLM binding site; other site 1179773004955 L1 loop; other site 1179773004956 DNA binding site [nucleotide binding] 1179773004957 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1179773004958 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1179773004959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773004960 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1179773004961 NAD(P) binding site [chemical binding]; other site 1179773004962 active site 1179773004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773004964 metabolite-proton symporter; Region: 2A0106; TIGR00883 1179773004965 putative substrate translocation pore; other site 1179773004966 GAF domain; Region: GAF_2; pfam13185 1179773004967 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1179773004968 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773004969 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1179773004970 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1179773004971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1179773004972 nucleotide binding region [chemical binding]; other site 1179773004973 ATP-binding site [chemical binding]; other site 1179773004974 SpoOM protein; Region: Spo0M; pfam07070 1179773004975 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1179773004976 WD domain, G-beta repeat; Region: WD40; pfam00400 1179773004977 WD40 repeats; Region: WD40; smart00320 1179773004978 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773004979 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773004980 structural tetrad; other site 1179773004981 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773004982 structural tetrad; other site 1179773004983 WD domain, G-beta repeat; Region: WD40; pfam00400 1179773004984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773004985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773004986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773004987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773004988 active site 1179773004989 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773004990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773004991 NAD(P) binding site [chemical binding]; other site 1179773004992 active site 1179773004993 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773004994 metal ion-dependent adhesion site (MIDAS); other site 1179773004995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773004996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773004997 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1179773004998 putative active site [active] 1179773004999 putative catalytic site [active] 1179773005000 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773005001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773005002 NAD(P) binding site [chemical binding]; other site 1179773005003 active site 1179773005004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773005005 NAD(P) binding site [chemical binding]; other site 1179773005006 active site 1179773005007 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773005008 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773005009 NAD(P) binding site [chemical binding]; other site 1179773005010 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 1179773005011 active site 1179773005012 catalytic triad [active] 1179773005013 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1179773005014 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1179773005015 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1179773005016 TrkA-C domain; Region: TrkA_C; pfam02080 1179773005017 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1179773005018 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1179773005019 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1179773005020 cytidylate kinase; Provisional; Region: cmk; PRK00023 1179773005021 CMP-binding site; other site 1179773005022 The sites determining sugar specificity; other site 1179773005023 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773005024 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773005025 putative acyl-acceptor binding pocket; other site 1179773005026 GTP-binding protein Der; Reviewed; Region: PRK03003 1179773005027 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1179773005028 G1 box; other site 1179773005029 GTP/Mg2+ binding site [chemical binding]; other site 1179773005030 Switch I region; other site 1179773005031 G2 box; other site 1179773005032 Switch II region; other site 1179773005033 G3 box; other site 1179773005034 G4 box; other site 1179773005035 G5 box; other site 1179773005036 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1179773005037 G1 box; other site 1179773005038 GTP/Mg2+ binding site [chemical binding]; other site 1179773005039 Switch I region; other site 1179773005040 G2 box; other site 1179773005041 G3 box; other site 1179773005042 Switch II region; other site 1179773005043 G4 box; other site 1179773005044 G5 box; other site 1179773005045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005047 active site 1179773005048 phosphorylation site [posttranslational modification] 1179773005049 intermolecular recognition site; other site 1179773005050 dimerization interface [polypeptide binding]; other site 1179773005051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005052 DNA binding residues [nucleotide binding] 1179773005053 dimerization interface [polypeptide binding]; other site 1179773005054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773005055 ATP binding site [chemical binding]; other site 1179773005056 Mg2+ binding site [ion binding]; other site 1179773005057 G-X-G motif; other site 1179773005058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773005059 active site 1179773005060 Int/Topo IB signature motif; other site 1179773005061 DNA binding site [nucleotide binding] 1179773005062 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1179773005063 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1179773005064 polymerase nucleotide-binding site; other site 1179773005065 DNA-binding residues [nucleotide binding]; DNA binding site 1179773005066 nucleotide binding site [chemical binding]; other site 1179773005067 primase nucleotide-binding site [nucleotide binding]; other site 1179773005068 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1179773005069 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1179773005070 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1179773005071 dimer interface [polypeptide binding]; other site 1179773005072 ssDNA binding site [nucleotide binding]; other site 1179773005073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1179773005074 TrwC relaxase; Region: TrwC; pfam08751 1179773005075 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1179773005076 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1179773005077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773005078 Walker A motif; other site 1179773005079 ATP binding site [chemical binding]; other site 1179773005080 Walker B motif; other site 1179773005081 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1179773005082 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1179773005083 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1179773005084 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1179773005085 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1179773005086 CT1975-like protein; Region: Cas_CT1975; pfam09344 1179773005087 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1179773005088 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1179773005089 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1179773005090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1179773005091 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1179773005092 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1179773005093 AAA-like domain; Region: AAA_10; pfam12846 1179773005094 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1179773005095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773005096 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773005097 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1179773005098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773005099 non-specific DNA binding site [nucleotide binding]; other site 1179773005100 salt bridge; other site 1179773005101 sequence-specific DNA binding site [nucleotide binding]; other site 1179773005102 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773005103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773005104 salt bridge; other site 1179773005105 non-specific DNA binding site [nucleotide binding]; other site 1179773005106 sequence-specific DNA binding site [nucleotide binding]; other site 1179773005107 NB-ARC domain; Region: NB-ARC; pfam00931 1179773005108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005110 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005111 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773005112 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1179773005113 Immunity protein Imm1; Region: Imm1; pfam14430 1179773005114 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 1179773005115 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773005116 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773005117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773005118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773005119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773005120 non-specific DNA binding site [nucleotide binding]; other site 1179773005121 salt bridge; other site 1179773005122 sequence-specific DNA binding site [nucleotide binding]; other site 1179773005123 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1179773005124 catalytic motif [active] 1179773005125 Zn binding site [ion binding]; other site 1179773005126 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1179773005127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1179773005128 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1179773005129 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1179773005130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1179773005131 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1179773005132 MULE transposase domain; Region: MULE; pfam10551 1179773005133 DDE superfamily endonuclease; Region: DDE_5; cl17874 1179773005134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773005135 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773005136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773005137 Berberine and berberine like; Region: BBE; pfam08031 1179773005138 DDE superfamily endonuclease; Region: DDE_5; cl17874 1179773005139 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1179773005140 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1179773005141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1179773005142 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1179773005143 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1179773005144 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1179773005145 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1179773005146 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1179773005147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773005148 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1179773005149 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1179773005150 Int/Topo IB signature motif; other site 1179773005151 YcxB-like protein; Region: YcxB; pfam14317 1179773005152 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773005153 active site 1179773005154 DNA binding site [nucleotide binding] 1179773005155 Int/Topo IB signature motif; other site 1179773005156 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1179773005157 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1179773005158 TIR domain; Region: TIR_2; pfam13676 1179773005159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773005160 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773005161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773005162 Short repeats of unknown function; Region: ALF; pfam03752 1179773005163 Short repeats of unknown function; Region: ALF; pfam03752 1179773005164 Short repeats of unknown function; Region: ALF; pfam03752 1179773005165 SIR2-like domain; Region: SIR2_2; pfam13289 1179773005166 Integrase core domain; Region: rve; pfam00665 1179773005167 Integrase core domain; Region: rve_3; pfam13683 1179773005168 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 1179773005169 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 1179773005170 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1179773005171 ATP binding site [chemical binding]; other site 1179773005172 substrate interface [chemical binding]; other site 1179773005173 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1179773005174 active site 1179773005175 NTP binding site [chemical binding]; other site 1179773005176 metal binding triad [ion binding]; metal-binding site 1179773005177 TIR domain; Region: TIR_2; pfam13676 1179773005178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773005179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773005180 non-specific DNA binding site [nucleotide binding]; other site 1179773005181 salt bridge; other site 1179773005182 sequence-specific DNA binding site [nucleotide binding]; other site 1179773005183 NB-ARC domain; Region: NB-ARC; pfam00931 1179773005184 TIR domain; Region: TIR_2; pfam13676 1179773005185 Caspase domain; Region: Peptidase_C14; pfam00656 1179773005186 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1179773005187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773005188 ATP binding site [chemical binding]; other site 1179773005189 putative Mg++ binding site [ion binding]; other site 1179773005190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773005191 nucleotide binding region [chemical binding]; other site 1179773005192 ATP-binding site [chemical binding]; other site 1179773005193 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1179773005194 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1179773005195 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1179773005196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1179773005197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1179773005198 SEFIR domain; Region: SEFIR; pfam08357 1179773005199 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1179773005200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773005201 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1179773005202 SIR2-like domain; Region: SIR2_2; pfam13289 1179773005203 Superfamily II helicase [General function prediction only]; Region: COG1204 1179773005204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773005205 ATP binding site [chemical binding]; other site 1179773005206 putative Mg++ binding site [ion binding]; other site 1179773005207 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1179773005208 ATP-binding site [chemical binding]; other site 1179773005209 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1179773005210 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1179773005211 nudix motif; other site 1179773005212 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1179773005213 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1179773005214 nudix motif; other site 1179773005215 nudix motif; other site 1179773005216 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1179773005217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1179773005218 ligand binding site [chemical binding]; other site 1179773005219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773005220 metal ion-dependent adhesion site (MIDAS); other site 1179773005221 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1179773005222 Integrase core domain; Region: rve_3; cl15866 1179773005223 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1179773005224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1179773005225 Winged helix-turn helix; Region: HTH_29; pfam13551 1179773005226 Helix-turn-helix domain; Region: HTH_28; pfam13518 1179773005227 Winged helix-turn helix; Region: HTH_33; pfam13592 1179773005228 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773005229 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773005230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773005231 DNA binding residues [nucleotide binding] 1179773005232 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1179773005233 Ligand Binding Site [chemical binding]; other site 1179773005234 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1179773005235 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1179773005236 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1179773005237 active site 1179773005238 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1179773005239 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1179773005240 active site 1179773005241 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773005242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773005243 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773005244 Integrase core domain; Region: rve; pfam00665 1179773005245 AAA domain; Region: AAA_22; pfam13401 1179773005246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773005250 binding surface 1179773005251 TPR motif; other site 1179773005252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005253 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1179773005254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773005255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005256 active site 1179773005257 phosphorylation site [posttranslational modification] 1179773005258 intermolecular recognition site; other site 1179773005259 dimerization interface [polypeptide binding]; other site 1179773005260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773005261 DNA binding site [nucleotide binding] 1179773005262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773005263 dimerization interface [polypeptide binding]; other site 1179773005264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773005265 dimer interface [polypeptide binding]; other site 1179773005266 phosphorylation site [posttranslational modification] 1179773005267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773005268 ATP binding site [chemical binding]; other site 1179773005269 G-X-G motif; other site 1179773005270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773005271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773005272 dimerization interface [polypeptide binding]; other site 1179773005273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773005274 dimer interface [polypeptide binding]; other site 1179773005275 phosphorylation site [posttranslational modification] 1179773005276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1179773005277 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1179773005278 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1179773005279 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773005280 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773005281 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773005282 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773005283 protein-splicing catalytic site; other site 1179773005284 thioester formation/cholesterol transfer; other site 1179773005285 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1179773005286 Transposase; Region: HTH_Tnp_1; pfam01527 1179773005287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1179773005288 HTH-like domain; Region: HTH_21; pfam13276 1179773005289 Integrase core domain; Region: rve; pfam00665 1179773005290 Integrase core domain; Region: rve_2; pfam13333 1179773005291 Transposase domain (DUF772); Region: DUF772; pfam05598 1179773005292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773005293 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1179773005294 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 1179773005295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005297 DNA binding residues [nucleotide binding] 1179773005298 dimerization interface [polypeptide binding]; other site 1179773005299 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773005300 hypothetical protein; Provisional; Region: PRK07236 1179773005301 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773005302 acyl carrier protein; Provisional; Region: acpP; PRK00982 1179773005303 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1179773005304 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1179773005305 dimer interface [polypeptide binding]; other site 1179773005306 active site 1179773005307 CoA binding pocket [chemical binding]; other site 1179773005308 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1179773005309 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1179773005310 dimer interface [polypeptide binding]; other site 1179773005311 active site 1179773005312 CoA binding pocket [chemical binding]; other site 1179773005313 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1179773005314 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773005315 CoenzymeA binding site [chemical binding]; other site 1179773005316 subunit interaction site [polypeptide binding]; other site 1179773005317 PHB binding site; other site 1179773005318 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1179773005319 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1179773005320 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1179773005321 NAD(P) binding site [chemical binding]; other site 1179773005322 homotetramer interface [polypeptide binding]; other site 1179773005323 homodimer interface [polypeptide binding]; other site 1179773005324 active site 1179773005325 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773005326 active site 2 [active] 1179773005327 active site 1 [active] 1179773005328 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1179773005329 active site 1179773005330 catalytic site [active] 1179773005331 acyl-CoA synthetase; Validated; Region: PRK06188 1179773005332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005334 AMP binding site [chemical binding]; other site 1179773005335 active site 1179773005336 acyl-activating enzyme (AAE) consensus motif; other site 1179773005337 CoA binding site [chemical binding]; other site 1179773005338 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1179773005339 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1179773005340 substrate-cofactor binding pocket; other site 1179773005341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773005342 catalytic residue [active] 1179773005343 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1179773005344 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1179773005345 acyl-activating enzyme (AAE) consensus motif; other site 1179773005346 putative AMP binding site [chemical binding]; other site 1179773005347 putative active site [active] 1179773005348 putative CoA binding site [chemical binding]; other site 1179773005349 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1179773005350 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773005351 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773005352 active site 1179773005353 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773005354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1179773005355 dimer interface [polypeptide binding]; other site 1179773005356 active site 1179773005357 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1179773005358 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1179773005359 putative active site; other site 1179773005360 catalytic residue [active] 1179773005361 3-dehydroquinate synthase; Provisional; Region: PRK02290 1179773005362 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773005363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005364 acyl-activating enzyme (AAE) consensus motif; other site 1179773005365 AMP binding site [chemical binding]; other site 1179773005366 active site 1179773005367 CoA binding site [chemical binding]; other site 1179773005368 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1179773005369 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773005370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005371 putative substrate translocation pore; other site 1179773005372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005373 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773005374 NB-ARC domain; Region: NB-ARC; pfam00931 1179773005375 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1179773005376 Part of AAA domain; Region: AAA_19; pfam13245 1179773005377 Family description; Region: UvrD_C_2; pfam13538 1179773005378 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773005379 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773005380 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773005381 RHS Repeat; Region: RHS_repeat; pfam05593 1179773005382 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773005383 RHS Repeat; Region: RHS_repeat; pfam05593 1179773005384 RHS Repeat; Region: RHS_repeat; cl11982 1179773005385 RHS Repeat; Region: RHS_repeat; cl11982 1179773005386 RHS Repeat; Region: RHS_repeat; pfam05593 1179773005387 RHS Repeat; Region: RHS_repeat; pfam05593 1179773005388 RHS Repeat; Region: RHS_repeat; cl11982 1179773005389 RHS protein; Region: RHS; pfam03527 1179773005390 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773005391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773005392 active site 1179773005393 DNA binding site [nucleotide binding] 1179773005394 Int/Topo IB signature motif; other site 1179773005395 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1179773005396 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1179773005397 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1179773005398 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1179773005399 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773005400 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773005401 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773005402 protein-splicing catalytic site; other site 1179773005403 thioester formation/cholesterol transfer; other site 1179773005404 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1179773005405 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1179773005406 GIY-YIG motif/motif A; other site 1179773005407 active site 1179773005408 catalytic site [active] 1179773005409 metal binding site [ion binding]; metal-binding site 1179773005410 CHAT domain; Region: CHAT; pfam12770 1179773005411 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773005412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773005413 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773005414 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773005415 Ca2+ binding site [ion binding]; other site 1179773005416 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1179773005417 ssDNA binding site; other site 1179773005418 generic binding surface II; other site 1179773005419 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1179773005420 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1179773005421 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773005422 metal ion-dependent adhesion site (MIDAS); other site 1179773005423 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773005424 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773005425 putative sugar binding sites [chemical binding]; other site 1179773005426 Q-X-W motif; other site 1179773005427 molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355 1179773005428 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1179773005429 ATP binding site [chemical binding]; other site 1179773005430 substrate interface [chemical binding]; other site 1179773005431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773005432 TPR motif; other site 1179773005433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005434 binding surface 1179773005435 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005436 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773005437 G1 box; other site 1179773005438 GTP/Mg2+ binding site [chemical binding]; other site 1179773005439 G2 box; other site 1179773005440 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1179773005441 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773005442 nucleotide binding site [chemical binding]; other site 1179773005443 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773005444 SBD interface [polypeptide binding]; other site 1179773005445 Protein kinase domain; Region: Pkinase; pfam00069 1179773005446 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773005447 active site 1179773005448 ATP binding site [chemical binding]; other site 1179773005449 substrate binding site [chemical binding]; other site 1179773005450 activation loop (A-loop); other site 1179773005451 GUN4-like; Region: GUN4; pfam05419 1179773005452 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1179773005453 AAA ATPase domain; Region: AAA_16; pfam13191 1179773005454 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1179773005455 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1179773005456 GAF domain; Region: GAF_2; pfam13185 1179773005457 GAF domain; Region: GAF; cl17456 1179773005458 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773005459 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773005460 GAF domain; Region: GAF; cl17456 1179773005461 ANTAR domain; Region: ANTAR; pfam03861 1179773005462 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1179773005463 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773005464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773005465 catalytic residue [active] 1179773005466 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1179773005467 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773005468 amidohydrolase; Region: amidohydrolases; TIGR01891 1179773005469 metal binding site [ion binding]; metal-binding site 1179773005470 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1179773005471 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1179773005472 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1179773005473 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1179773005474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773005475 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773005476 Walker A motif; other site 1179773005477 ATP binding site [chemical binding]; other site 1179773005478 Walker B motif; other site 1179773005479 arginine finger; other site 1179773005480 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773005481 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1179773005482 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1179773005483 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1179773005484 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773005485 putative sugar binding sites [chemical binding]; other site 1179773005486 Q-X-W motif; other site 1179773005487 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773005488 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1179773005489 DXD motif; other site 1179773005490 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1179773005491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773005492 active site 1179773005493 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1179773005494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773005495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773005496 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773005497 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773005498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773005499 S-adenosylmethionine binding site [chemical binding]; other site 1179773005500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005502 DNA binding residues [nucleotide binding] 1179773005503 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1179773005504 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1179773005505 nudix motif; other site 1179773005506 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1179773005507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773005508 Coenzyme A binding pocket [chemical binding]; other site 1179773005509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773005510 Coenzyme A binding pocket [chemical binding]; other site 1179773005511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773005512 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1179773005513 Walker A/P-loop; other site 1179773005514 ATP binding site [chemical binding]; other site 1179773005515 Q-loop/lid; other site 1179773005516 ABC transporter signature motif; other site 1179773005517 Walker B; other site 1179773005518 D-loop; other site 1179773005519 H-loop/switch region; other site 1179773005520 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1179773005521 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773005522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005523 putative substrate translocation pore; other site 1179773005524 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773005525 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773005526 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773005527 acyl-activating enzyme (AAE) consensus motif; other site 1179773005528 AMP binding site [chemical binding]; other site 1179773005529 Condensation domain; Region: Condensation; pfam00668 1179773005530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773005531 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1179773005532 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1179773005533 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1179773005534 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773005535 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005536 acyl-activating enzyme (AAE) consensus motif; other site 1179773005537 AMP binding site [chemical binding]; other site 1179773005538 active site 1179773005539 CoA binding site [chemical binding]; other site 1179773005540 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1179773005541 peptide synthase; Provisional; Region: PRK12316 1179773005542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773005543 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1179773005544 active sites [active] 1179773005545 tetramer interface [polypeptide binding]; other site 1179773005546 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773005547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005548 acyl-activating enzyme (AAE) consensus motif; other site 1179773005549 AMP binding site [chemical binding]; other site 1179773005550 active site 1179773005551 CoA binding site [chemical binding]; other site 1179773005552 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773005553 Condensation domain; Region: Condensation; pfam00668 1179773005554 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773005555 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773005556 NB-ARC domain; Region: NB-ARC; pfam00931 1179773005557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005558 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1179773005559 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773005560 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773005561 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1179773005562 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773005563 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773005564 TIGR03086 family protein; Region: TIGR03086 1179773005565 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1179773005566 DNA binding residues [nucleotide binding] 1179773005567 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773005568 drug binding residues [chemical binding]; other site 1179773005569 dimer interface [polypeptide binding]; other site 1179773005570 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1179773005571 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773005572 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773005573 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773005574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773005575 active site 1179773005576 ATP binding site [chemical binding]; other site 1179773005577 substrate binding site [chemical binding]; other site 1179773005578 activation loop (A-loop); other site 1179773005579 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773005580 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1179773005581 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1179773005582 MMPL family; Region: MMPL; pfam03176 1179773005583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773005584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773005585 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1179773005586 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1179773005587 transmembrane helices; other site 1179773005588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1179773005589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773005590 S-adenosylmethionine binding site [chemical binding]; other site 1179773005591 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773005592 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773005593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005594 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773005595 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773005596 RibD C-terminal domain; Region: RibD_C; cl17279 1179773005597 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1179773005598 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1179773005599 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773005600 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1179773005601 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1179773005602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773005603 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1179773005604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773005605 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1179773005606 Walker A/P-loop; other site 1179773005607 ATP binding site [chemical binding]; other site 1179773005608 Q-loop/lid; other site 1179773005609 ABC transporter signature motif; other site 1179773005610 Walker B; other site 1179773005611 D-loop; other site 1179773005612 H-loop/switch region; other site 1179773005613 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1179773005614 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773005615 FAD binding pocket [chemical binding]; other site 1179773005616 FAD binding motif [chemical binding]; other site 1179773005617 phosphate binding motif [ion binding]; other site 1179773005618 NAD binding pocket [chemical binding]; other site 1179773005619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773005620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773005621 Walker A/P-loop; other site 1179773005622 ATP binding site [chemical binding]; other site 1179773005623 Q-loop/lid; other site 1179773005624 ABC transporter signature motif; other site 1179773005625 Walker B; other site 1179773005626 D-loop; other site 1179773005627 H-loop/switch region; other site 1179773005628 EamA-like transporter family; Region: EamA; pfam00892 1179773005629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773005630 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1179773005631 acyl-activating enzyme (AAE) consensus motif; other site 1179773005632 AMP binding site [chemical binding]; other site 1179773005633 active site 1179773005634 CoA binding site [chemical binding]; other site 1179773005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773005636 S-adenosylmethionine binding site [chemical binding]; other site 1179773005637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773005638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773005639 catalytic tetrad [active] 1179773005640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1179773005641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773005642 ABC-ATPase subunit interface; other site 1179773005643 dimer interface [polypeptide binding]; other site 1179773005644 putative PBP binding regions; other site 1179773005645 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1179773005646 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773005647 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773005648 Walker A/P-loop; other site 1179773005649 ATP binding site [chemical binding]; other site 1179773005650 Q-loop/lid; other site 1179773005651 ABC transporter signature motif; other site 1179773005652 Walker B; other site 1179773005653 D-loop; other site 1179773005654 H-loop/switch region; other site 1179773005655 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773005656 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1179773005657 siderophore binding site; other site 1179773005658 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773005659 DNA binding site [nucleotide binding] 1179773005660 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773005661 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773005663 binding surface 1179773005664 TPR motif; other site 1179773005665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773005667 sequence-specific DNA binding site [nucleotide binding]; other site 1179773005668 salt bridge; other site 1179773005669 Cupin domain; Region: Cupin_2; pfam07883 1179773005670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773005671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773005672 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1179773005673 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1179773005674 ligand binding site [chemical binding]; other site 1179773005675 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 1179773005676 Secretory lipase; Region: LIP; pfam03583 1179773005677 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773005678 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773005679 Ca2+ binding site [ion binding]; other site 1179773005680 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773005681 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773005682 Ca2+ binding site [ion binding]; other site 1179773005683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773005684 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1179773005685 HTH domain; Region: HTH_11; pfam08279 1179773005686 WYL domain; Region: WYL; pfam13280 1179773005687 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1179773005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005689 putative substrate translocation pore; other site 1179773005690 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773005691 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773005692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773005693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773005694 active site 1179773005695 catalytic tetrad [active] 1179773005696 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1179773005697 catalytic Zn binding site [ion binding]; other site 1179773005698 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 1179773005699 structural Zn binding site [ion binding]; other site 1179773005700 tetramer interface [polypeptide binding]; other site 1179773005701 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1179773005702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773005703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773005704 active site 1179773005705 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773005706 classical (c) SDRs; Region: SDR_c; cd05233 1179773005707 NAD(P) binding site [chemical binding]; other site 1179773005708 active site 1179773005709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1179773005710 dimerization interface [polypeptide binding]; other site 1179773005711 putative DNA binding site [nucleotide binding]; other site 1179773005712 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1179773005713 putative Zn2+ binding site [ion binding]; other site 1179773005714 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773005715 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1179773005716 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773005717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773005718 dimer interface [polypeptide binding]; other site 1179773005719 conserved gate region; other site 1179773005720 putative PBP binding loops; other site 1179773005721 ABC-ATPase subunit interface; other site 1179773005722 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1179773005723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773005724 dimer interface [polypeptide binding]; other site 1179773005725 conserved gate region; other site 1179773005726 putative PBP binding loops; other site 1179773005727 ABC-ATPase subunit interface; other site 1179773005728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773005729 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773005730 Walker A/P-loop; other site 1179773005731 ATP binding site [chemical binding]; other site 1179773005732 Q-loop/lid; other site 1179773005733 ABC transporter signature motif; other site 1179773005734 Walker B; other site 1179773005735 D-loop; other site 1179773005736 H-loop/switch region; other site 1179773005737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773005738 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773005739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773005740 Walker A/P-loop; other site 1179773005741 ATP binding site [chemical binding]; other site 1179773005742 Q-loop/lid; other site 1179773005743 ABC transporter signature motif; other site 1179773005744 Walker B; other site 1179773005745 D-loop; other site 1179773005746 H-loop/switch region; other site 1179773005747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773005748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773005749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773005750 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1179773005751 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1179773005752 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773005753 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1179773005754 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1179773005755 hypothetical protein; Validated; Region: PRK07581 1179773005756 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1179773005757 FtsX-like permease family; Region: FtsX; pfam02687 1179773005758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773005759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773005760 Walker A/P-loop; other site 1179773005761 ATP binding site [chemical binding]; other site 1179773005762 Q-loop/lid; other site 1179773005763 ABC transporter signature motif; other site 1179773005764 Walker B; other site 1179773005765 D-loop; other site 1179773005766 H-loop/switch region; other site 1179773005767 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1179773005768 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773005769 Walker A/P-loop; other site 1179773005770 ATP binding site [chemical binding]; other site 1179773005771 Q-loop/lid; other site 1179773005772 ABC transporter signature motif; other site 1179773005773 Walker B; other site 1179773005774 D-loop; other site 1179773005775 H-loop/switch region; other site 1179773005776 Histidine kinase; Region: HisKA_3; pfam07730 1179773005777 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773005778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005780 active site 1179773005781 phosphorylation site [posttranslational modification] 1179773005782 intermolecular recognition site; other site 1179773005783 dimerization interface [polypeptide binding]; other site 1179773005784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005785 dimerization interface [polypeptide binding]; other site 1179773005786 DNA binding residues [nucleotide binding] 1179773005787 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1179773005788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773005789 Walker A/P-loop; other site 1179773005790 ATP binding site [chemical binding]; other site 1179773005791 Q-loop/lid; other site 1179773005792 ABC transporter signature motif; other site 1179773005793 Walker B; other site 1179773005794 D-loop; other site 1179773005795 H-loop/switch region; other site 1179773005796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005798 active site 1179773005799 phosphorylation site [posttranslational modification] 1179773005800 intermolecular recognition site; other site 1179773005801 dimerization interface [polypeptide binding]; other site 1179773005802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005803 DNA binding residues [nucleotide binding] 1179773005804 dimerization interface [polypeptide binding]; other site 1179773005805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773005806 Histidine kinase; Region: HisKA_3; pfam07730 1179773005807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773005808 ATP binding site [chemical binding]; other site 1179773005809 Mg2+ binding site [ion binding]; other site 1179773005810 G-X-G motif; other site 1179773005811 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1179773005812 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1179773005813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773005814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773005815 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773005816 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1179773005817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773005818 Walker A/P-loop; other site 1179773005819 ATP binding site [chemical binding]; other site 1179773005820 Q-loop/lid; other site 1179773005821 ABC transporter signature motif; other site 1179773005822 Walker B; other site 1179773005823 D-loop; other site 1179773005824 H-loop/switch region; other site 1179773005825 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773005826 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773005827 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1179773005828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773005829 catalytic residue [active] 1179773005830 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773005831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773005832 Walker A motif; other site 1179773005833 ATP binding site [chemical binding]; other site 1179773005834 NB-ARC domain; Region: NB-ARC; pfam00931 1179773005835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005837 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773005838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005840 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005841 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773005842 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1179773005843 Lamin Tail Domain; Region: LTD; pfam00932 1179773005844 SdiA-regulated; Region: SdiA-regulated; cd09971 1179773005845 putative active site [active] 1179773005846 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773005847 DNA binding site [nucleotide binding] 1179773005848 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773005849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773005850 TPR motif; other site 1179773005851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005852 binding surface 1179773005853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773005855 binding surface 1179773005856 TPR motif; other site 1179773005857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773005858 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773005859 active site 1179773005860 catalytic residues [active] 1179773005861 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1179773005862 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773005863 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773005864 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773005865 calcium binding site 2 [ion binding]; other site 1179773005866 active site 1179773005867 catalytic triad [active] 1179773005868 calcium binding site 1 [ion binding]; other site 1179773005869 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773005870 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773005871 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1179773005872 Zn binding site [ion binding]; other site 1179773005873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005874 metabolite-proton symporter; Region: 2A0106; TIGR00883 1179773005875 putative substrate translocation pore; other site 1179773005876 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773005877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005879 active site 1179773005880 phosphorylation site [posttranslational modification] 1179773005881 intermolecular recognition site; other site 1179773005882 dimerization interface [polypeptide binding]; other site 1179773005883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005884 DNA binding residues [nucleotide binding] 1179773005885 dimerization interface [polypeptide binding]; other site 1179773005886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773005887 DNA-binding site [nucleotide binding]; DNA binding site 1179773005888 2-isopropylmalate synthase; Validated; Region: PRK03739 1179773005889 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1179773005890 active site 1179773005891 catalytic residues [active] 1179773005892 metal binding site [ion binding]; metal-binding site 1179773005893 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1179773005894 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1179773005895 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1179773005896 proline aminopeptidase P II; Provisional; Region: PRK10879 1179773005897 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1179773005898 active site 1179773005899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773005900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773005901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773005902 dimerization interface [polypeptide binding]; other site 1179773005903 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1179773005904 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1179773005905 FOG: PKD repeat [General function prediction only]; Region: COG3291 1179773005906 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1179773005907 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1179773005908 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 1179773005909 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773005910 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773005911 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773005912 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773005913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773005914 putative substrate translocation pore; other site 1179773005915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1179773005916 catalytic residues [active] 1179773005917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1179773005918 active site residue [active] 1179773005919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773005920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773005921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773005922 dimerization interface [polypeptide binding]; other site 1179773005923 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1179773005924 Na binding site [ion binding]; other site 1179773005925 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1179773005926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773005927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773005928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773005929 dimerization interface [polypeptide binding]; other site 1179773005930 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1179773005931 Zn binding site [ion binding]; other site 1179773005932 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773005933 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1179773005934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773005935 Walker A/P-loop; other site 1179773005936 ATP binding site [chemical binding]; other site 1179773005937 Q-loop/lid; other site 1179773005938 ABC transporter signature motif; other site 1179773005939 Walker B; other site 1179773005940 D-loop; other site 1179773005941 H-loop/switch region; other site 1179773005942 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1179773005943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773005945 active site 1179773005946 phosphorylation site [posttranslational modification] 1179773005947 intermolecular recognition site; other site 1179773005948 dimerization interface [polypeptide binding]; other site 1179773005949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773005950 DNA binding residues [nucleotide binding] 1179773005951 dimerization interface [polypeptide binding]; other site 1179773005952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773005953 Histidine kinase; Region: HisKA_3; pfam07730 1179773005954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773005955 ATP binding site [chemical binding]; other site 1179773005956 Mg2+ binding site [ion binding]; other site 1179773005957 G-X-G motif; other site 1179773005958 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1179773005959 active site 1179773005960 catalytic residues [active] 1179773005961 metal binding site [ion binding]; metal-binding site 1179773005962 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1179773005963 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773005964 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1179773005965 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1179773005966 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1179773005967 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1179773005968 Ca binding site [ion binding]; other site 1179773005969 active site 1179773005970 catalytic site [active] 1179773005971 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1179773005972 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1179773005973 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1179773005974 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1179773005975 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1179773005976 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773005977 active site 1179773005978 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773005979 active site 1179773005980 metal binding site [ion binding]; metal-binding site 1179773005981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773005982 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1179773005983 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773005984 acyl-activating enzyme (AAE) consensus motif; other site 1179773005985 AMP binding site [chemical binding]; other site 1179773005986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773005987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773005988 active site 1179773005989 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1179773005990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773005991 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1179773005992 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1179773005993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773005994 catalytic residue [active] 1179773005995 Amidohydrolase; Region: Amidohydro_2; pfam04909 1179773005996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773005997 active site 2 [active] 1179773005998 active site 1 [active] 1179773005999 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1179773006000 putative deacylase active site [active] 1179773006001 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1179773006002 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1179773006003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006005 DNA binding residues [nucleotide binding] 1179773006006 dimerization interface [polypeptide binding]; other site 1179773006007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773006008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773006009 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773006010 dimerization interface [polypeptide binding]; other site 1179773006011 substrate binding pocket [chemical binding]; other site 1179773006012 Cupin domain; Region: Cupin_2; cl17218 1179773006013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773006014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773006015 NAD(P) binding site [chemical binding]; other site 1179773006016 active site 1179773006017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773006018 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1179773006019 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1179773006020 active site 1179773006021 GIY-YIG motif/motif A; other site 1179773006022 catalytic site [active] 1179773006023 metal binding site [ion binding]; metal-binding site 1179773006024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773006025 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1179773006026 dimer interface [polypeptide binding]; other site 1179773006027 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 1179773006028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773006029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773006030 Walker A/P-loop; other site 1179773006031 ATP binding site [chemical binding]; other site 1179773006032 Q-loop/lid; other site 1179773006033 ABC transporter signature motif; other site 1179773006034 Walker B; other site 1179773006035 D-loop; other site 1179773006036 H-loop/switch region; other site 1179773006037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773006038 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1179773006039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773006040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773006041 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773006042 Ca2+ binding site [ion binding]; other site 1179773006043 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773006044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773006045 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773006046 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773006047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773006048 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773006049 Walker A/P-loop; other site 1179773006050 ATP binding site [chemical binding]; other site 1179773006051 Q-loop/lid; other site 1179773006052 ABC transporter signature motif; other site 1179773006053 Walker B; other site 1179773006054 D-loop; other site 1179773006055 H-loop/switch region; other site 1179773006056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006058 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773006059 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773006060 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773006061 active site 1179773006062 ATP binding site [chemical binding]; other site 1179773006063 substrate binding site [chemical binding]; other site 1179773006064 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1179773006065 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773006066 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773006067 Walker A/P-loop; other site 1179773006068 ATP binding site [chemical binding]; other site 1179773006069 Q-loop/lid; other site 1179773006070 ABC transporter signature motif; other site 1179773006071 Walker B; other site 1179773006072 D-loop; other site 1179773006073 H-loop/switch region; other site 1179773006074 Predicted transcriptional regulators [Transcription]; Region: COG1725 1179773006075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773006076 DNA-binding site [nucleotide binding]; DNA binding site 1179773006077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1179773006078 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1179773006079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006081 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773006082 active site 1179773006083 substrate binding sites [chemical binding]; other site 1179773006084 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773006085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006087 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1179773006088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773006089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773006090 Histidine kinase; Region: HisKA_3; pfam07730 1179773006091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773006093 active site 1179773006094 phosphorylation site [posttranslational modification] 1179773006095 intermolecular recognition site; other site 1179773006096 dimerization interface [polypeptide binding]; other site 1179773006097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006098 DNA binding residues [nucleotide binding] 1179773006099 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1179773006100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773006101 dimerization interface [polypeptide binding]; other site 1179773006102 putative DNA binding site [nucleotide binding]; other site 1179773006103 putative Zn2+ binding site [ion binding]; other site 1179773006104 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773006105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773006106 Protein of unknown function (DUF418); Region: DUF418; cl12135 1179773006107 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1179773006108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773006109 active site 1179773006110 Domain of unknown function (DUF427); Region: DUF427; cl00998 1179773006111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1179773006112 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 1179773006113 putative uracil binding site [chemical binding]; other site 1179773006114 putative active site [active] 1179773006115 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773006116 HTH domain; Region: HTH_11; pfam08279 1179773006117 WYL domain; Region: WYL; pfam13280 1179773006118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773006119 NAD(P) binding site [chemical binding]; other site 1179773006120 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773006121 active site 1179773006122 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1179773006123 nucleotide binding site [chemical binding]; other site 1179773006124 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1179773006125 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1179773006126 active site 1179773006127 DNA binding site [nucleotide binding] 1179773006128 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1179773006129 DNA binding site [nucleotide binding] 1179773006130 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773006131 DinB superfamily; Region: DinB_2; pfam12867 1179773006132 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1179773006133 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1179773006134 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773006135 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1179773006136 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773006137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773006138 metal binding site [ion binding]; metal-binding site 1179773006139 active site 1179773006140 I-site; other site 1179773006141 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1179773006142 active site 1179773006143 putative DNA-binding cleft [nucleotide binding]; other site 1179773006144 dimer interface [polypeptide binding]; other site 1179773006145 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1179773006146 RuvA N terminal domain; Region: RuvA_N; pfam01330 1179773006147 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1179773006148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773006149 Walker A motif; other site 1179773006150 ATP binding site [chemical binding]; other site 1179773006151 Walker B motif; other site 1179773006152 arginine finger; other site 1179773006153 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1179773006154 Preprotein translocase subunit; Region: YajC; pfam02699 1179773006155 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1179773006156 Protein export membrane protein; Region: SecD_SecF; cl14618 1179773006157 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1179773006158 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1179773006159 Protein export membrane protein; Region: SecD_SecF; cl14618 1179773006160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1179773006161 active site 1179773006162 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1179773006163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1179773006164 Zn2+ binding site [ion binding]; other site 1179773006165 Mg2+ binding site [ion binding]; other site 1179773006166 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1179773006167 synthetase active site [active] 1179773006168 NTP binding site [chemical binding]; other site 1179773006169 metal binding site [ion binding]; metal-binding site 1179773006170 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1179773006171 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1179773006172 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1179773006173 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1179773006174 active site 1179773006175 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1179773006176 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1179773006177 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1179773006178 dimer interface [polypeptide binding]; other site 1179773006179 motif 1; other site 1179773006180 active site 1179773006181 motif 2; other site 1179773006182 motif 3; other site 1179773006183 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1179773006184 anticodon binding site; other site 1179773006185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773006186 S-adenosylmethionine binding site [chemical binding]; other site 1179773006187 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1179773006188 YibE/F-like protein; Region: YibE_F; pfam07907 1179773006189 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1179773006190 FMN binding site [chemical binding]; other site 1179773006191 dimer interface [polypeptide binding]; other site 1179773006192 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1179773006193 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773006194 active site 1179773006195 nucleotide binding site [chemical binding]; other site 1179773006196 HIGH motif; other site 1179773006197 KMSKS motif; other site 1179773006198 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1179773006199 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1179773006200 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773006201 protein-splicing catalytic site; other site 1179773006202 thioester formation/cholesterol transfer; other site 1179773006203 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1179773006204 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1179773006205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773006206 FeS/SAM binding site; other site 1179773006207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773006208 NAD(P) binding site [chemical binding]; other site 1179773006209 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1179773006210 active site 1179773006211 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1179773006212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006216 TIGR03084 family protein; Region: TIGR03084 1179773006217 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773006218 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1179773006219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773006220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773006221 active site 1179773006222 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1179773006223 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773006224 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1179773006225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773006226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773006227 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773006228 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773006229 carboxyltransferase (CT) interaction site; other site 1179773006230 biotinylation site [posttranslational modification]; other site 1179773006231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773006232 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1179773006233 active site 1179773006234 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1179773006235 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773006236 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773006237 calcium binding site 2 [ion binding]; other site 1179773006238 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773006239 active site 1179773006240 catalytic triad [active] 1179773006241 calcium binding site 1 [ion binding]; other site 1179773006242 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773006243 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773006244 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773006245 calcium binding site 2 [ion binding]; other site 1179773006246 active site 1179773006247 catalytic triad [active] 1179773006248 calcium binding site 1 [ion binding]; other site 1179773006249 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773006250 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773006251 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773006252 calcium binding site 2 [ion binding]; other site 1179773006253 active site 1179773006254 catalytic triad [active] 1179773006255 calcium binding site 1 [ion binding]; other site 1179773006256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773006257 Coenzyme A binding pocket [chemical binding]; other site 1179773006258 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773006259 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773006260 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773006261 calcium binding site 2 [ion binding]; other site 1179773006262 active site 1179773006263 catalytic triad [active] 1179773006264 calcium binding site 1 [ion binding]; other site 1179773006265 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1179773006266 active site 1179773006267 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1179773006268 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1179773006269 dimer interface [polypeptide binding]; other site 1179773006270 anticodon binding site; other site 1179773006271 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1179773006272 homodimer interface [polypeptide binding]; other site 1179773006273 motif 1; other site 1179773006274 active site 1179773006275 motif 2; other site 1179773006276 GAD domain; Region: GAD; pfam02938 1179773006277 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773006278 active site 1179773006279 motif 3; other site 1179773006280 Domain of unknown function (DUF389); Region: DUF389; cl00781 1179773006281 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1179773006282 active site 1179773006283 catalytic triad [active] 1179773006284 oxyanion hole [active] 1179773006285 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1179773006286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773006287 active site 1179773006288 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1179773006289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773006290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773006291 dimer interface [polypeptide binding]; other site 1179773006292 phosphorylation site [posttranslational modification] 1179773006293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773006294 ATP binding site [chemical binding]; other site 1179773006295 Mg2+ binding site [ion binding]; other site 1179773006296 G-X-G motif; other site 1179773006297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773006299 active site 1179773006300 phosphorylation site [posttranslational modification] 1179773006301 intermolecular recognition site; other site 1179773006302 dimerization interface [polypeptide binding]; other site 1179773006303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773006304 DNA binding site [nucleotide binding] 1179773006305 CopC domain; Region: CopC; pfam04234 1179773006306 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1179773006307 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1179773006308 active site 1179773006309 metal binding site [ion binding]; metal-binding site 1179773006310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1179773006311 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1179773006312 active site 1179773006313 SUMO-1 interface [polypeptide binding]; other site 1179773006314 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773006315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773006316 RNA binding surface [nucleotide binding]; other site 1179773006317 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1179773006318 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1179773006319 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773006320 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773006321 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1179773006322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773006324 NAD(P) binding site [chemical binding]; other site 1179773006325 active site 1179773006326 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773006327 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773006328 inhibitor-cofactor binding pocket; inhibition site 1179773006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773006330 catalytic residue [active] 1179773006331 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1179773006332 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773006333 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773006334 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773006335 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773006336 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773006337 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773006338 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773006339 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1179773006340 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773006341 putative trimer interface [polypeptide binding]; other site 1179773006342 putative CoA binding site [chemical binding]; other site 1179773006343 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773006344 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773006345 inhibitor-cofactor binding pocket; inhibition site 1179773006346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773006347 catalytic residue [active] 1179773006348 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773006349 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1179773006350 putative trimer interface [polypeptide binding]; other site 1179773006351 putative active site [active] 1179773006352 putative substrate binding site [chemical binding]; other site 1179773006353 putative CoA binding site [chemical binding]; other site 1179773006354 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1179773006355 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1179773006356 translocation protein TolB; Provisional; Region: tolB; PRK01029 1179773006357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773006358 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1179773006359 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1179773006360 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1179773006361 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1179773006362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773006363 active site 1179773006364 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 1179773006365 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1179773006366 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773006367 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773006368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773006369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773006370 substrate binding pocket [chemical binding]; other site 1179773006371 membrane-bound complex binding site; other site 1179773006372 hinge residues; other site 1179773006373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773006374 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1179773006375 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1179773006376 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1179773006377 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1179773006378 Probable Catalytic site; other site 1179773006379 metal-binding site 1179773006380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1179773006381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773006382 putative homodimer interface [polypeptide binding]; other site 1179773006383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773006384 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773006385 active site 1179773006386 ATP binding site [chemical binding]; other site 1179773006387 substrate binding site [chemical binding]; other site 1179773006388 activation loop (A-loop); other site 1179773006389 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1179773006390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773006391 substrate binding site [chemical binding]; other site 1179773006392 oxyanion hole (OAH) forming residues; other site 1179773006393 trimer interface [polypeptide binding]; other site 1179773006394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773006395 Coenzyme A binding pocket [chemical binding]; other site 1179773006396 YCII-related domain; Region: YCII; pfam03795 1179773006397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006399 DNA binding residues [nucleotide binding] 1179773006400 dimerization interface [polypeptide binding]; other site 1179773006401 AAA ATPase domain; Region: AAA_16; pfam13191 1179773006402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006404 DNA binding residues [nucleotide binding] 1179773006405 dimerization interface [polypeptide binding]; other site 1179773006406 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1179773006407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773006408 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1179773006409 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1179773006410 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1179773006411 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1179773006412 RNA binding site [nucleotide binding]; other site 1179773006413 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773006414 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1179773006415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773006416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773006417 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1179773006418 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1179773006419 nucleophile elbow; other site 1179773006420 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773006421 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1179773006422 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1179773006423 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1179773006424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773006425 PGAP1-like protein; Region: PGAP1; pfam07819 1179773006426 enoyl-CoA hydratase; Provisional; Region: PRK06127 1179773006427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773006428 substrate binding site [chemical binding]; other site 1179773006429 oxyanion hole (OAH) forming residues; other site 1179773006430 trimer interface [polypeptide binding]; other site 1179773006431 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773006432 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1179773006433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773006434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773006435 DNA binding residues [nucleotide binding] 1179773006436 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773006437 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1179773006438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773006439 catalytic residues [active] 1179773006440 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773006441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773006442 HTH domain; Region: HTH_22; pfam13309 1179773006443 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1179773006444 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773006445 active site 1179773006446 dimer interface [polypeptide binding]; other site 1179773006447 motif 2; other site 1179773006448 motif 3; other site 1179773006449 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1179773006450 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773006451 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1179773006452 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1179773006453 active site 1179773006454 SAM binding site [chemical binding]; other site 1179773006455 putative homodimer interface [polypeptide binding]; other site 1179773006456 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1179773006457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773006458 S-adenosylmethionine binding site [chemical binding]; other site 1179773006459 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1179773006460 active site 1179773006461 SAM binding site [chemical binding]; other site 1179773006462 homodimer interface [polypeptide binding]; other site 1179773006463 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1179773006464 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1179773006465 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1179773006466 active site 1179773006467 SAM binding site [chemical binding]; other site 1179773006468 homodimer interface [polypeptide binding]; other site 1179773006469 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1179773006470 active site 1179773006471 SAM binding site [chemical binding]; other site 1179773006472 homodimer interface [polypeptide binding]; other site 1179773006473 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1179773006474 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1179773006475 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1179773006476 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1179773006477 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1179773006478 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1179773006479 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773006480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1179773006481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773006482 ABC-ATPase subunit interface; other site 1179773006483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773006484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773006485 dimer interface [polypeptide binding]; other site 1179773006486 conserved gate region; other site 1179773006487 putative PBP binding loops; other site 1179773006488 ABC-ATPase subunit interface; other site 1179773006489 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1179773006490 beta-galactosidase; Region: BGL; TIGR03356 1179773006491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773006492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773006493 DNA binding site [nucleotide binding] 1179773006494 domain linker motif; other site 1179773006495 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1179773006496 putative dimerization interface [polypeptide binding]; other site 1179773006497 putative ligand binding site [chemical binding]; other site 1179773006498 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1179773006499 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1179773006500 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1179773006501 catalytic residues [active] 1179773006502 catalytic nucleophile [active] 1179773006503 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1179773006504 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773006505 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1179773006506 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1179773006507 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1179773006508 dimer interface [polypeptide binding]; other site 1179773006509 active site 1179773006510 ADP-ribose binding site [chemical binding]; other site 1179773006511 nudix motif; other site 1179773006512 metal binding site [ion binding]; metal-binding site 1179773006513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773006514 non-specific DNA binding site [nucleotide binding]; other site 1179773006515 salt bridge; other site 1179773006516 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006517 Immunity protein Imm1; Region: Imm1; pfam14430 1179773006518 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773006519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773006520 Walker A/P-loop; other site 1179773006521 ATP binding site [chemical binding]; other site 1179773006522 Q-loop/lid; other site 1179773006523 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773006524 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773006525 structural tetrad; other site 1179773006526 MarR family; Region: MarR_2; pfam12802 1179773006527 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773006528 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773006529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773006530 nucleotide binding site [chemical binding]; other site 1179773006531 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773006532 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1179773006533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773006534 nucleotide binding site [chemical binding]; other site 1179773006535 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1179773006536 putative hydrophobic ligand binding site [chemical binding]; other site 1179773006537 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1179773006538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773006540 active site 1179773006541 phosphorylation site [posttranslational modification] 1179773006542 intermolecular recognition site; other site 1179773006543 dimerization interface [polypeptide binding]; other site 1179773006544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006545 DNA binding residues [nucleotide binding] 1179773006546 dimerization interface [polypeptide binding]; other site 1179773006547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773006548 Histidine kinase; Region: HisKA_3; pfam07730 1179773006549 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773006550 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773006551 Walker A/P-loop; other site 1179773006552 ATP binding site [chemical binding]; other site 1179773006553 Q-loop/lid; other site 1179773006554 ABC transporter signature motif; other site 1179773006555 Walker B; other site 1179773006556 D-loop; other site 1179773006557 H-loop/switch region; other site 1179773006558 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1179773006559 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1179773006560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773006561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773006562 DNA binding site [nucleotide binding] 1179773006563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773006564 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773006565 active site 1179773006566 catalytic tetrad [active] 1179773006567 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773006568 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1179773006569 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 1179773006570 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1179773006571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773006572 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1179773006573 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1179773006574 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1179773006575 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1179773006576 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1179773006577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773006578 motif II; other site 1179773006579 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1179773006580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773006581 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1179773006582 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1179773006583 putative hydrophobic ligand binding site [chemical binding]; other site 1179773006584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773006585 dimerization interface [polypeptide binding]; other site 1179773006586 putative DNA binding site [nucleotide binding]; other site 1179773006587 putative Zn2+ binding site [ion binding]; other site 1179773006588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1179773006589 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1179773006590 Transcription factor WhiB; Region: Whib; pfam02467 1179773006591 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1179773006592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773006593 DNA binding residues [nucleotide binding] 1179773006594 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773006595 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773006596 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1179773006597 YCII-related domain; Region: YCII; cl00999 1179773006598 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1179773006599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773006600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773006601 DNA binding residues [nucleotide binding] 1179773006602 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1179773006603 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773006604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773006605 non-specific DNA binding site [nucleotide binding]; other site 1179773006606 salt bridge; other site 1179773006607 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006608 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1179773006609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773006610 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006611 salt bridge; other site 1179773006612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006614 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1179773006615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773006618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773006619 non-specific DNA binding site [nucleotide binding]; other site 1179773006620 salt bridge; other site 1179773006621 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006622 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1179773006623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1179773006624 Rhodanese-like domain; Region: Rhodanese; pfam00581 1179773006625 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1179773006626 active site residue [active] 1179773006627 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773006628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773006629 DNA-binding site [nucleotide binding]; DNA binding site 1179773006630 UTRA domain; Region: UTRA; pfam07702 1179773006631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1179773006632 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773006633 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773006634 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1179773006635 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1179773006636 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1179773006637 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773006638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773006639 translocation protein TolB; Provisional; Region: tolB; PRK04792 1179773006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773006641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773006642 putative substrate translocation pore; other site 1179773006643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773006644 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773006645 active site 1179773006646 metal binding site [ion binding]; metal-binding site 1179773006647 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1179773006648 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1179773006649 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1179773006650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773006651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773006652 dimerization interface [polypeptide binding]; other site 1179773006653 LysE type translocator; Region: LysE; cl00565 1179773006654 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773006655 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773006656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006658 DNA binding residues [nucleotide binding] 1179773006659 dimerization interface [polypeptide binding]; other site 1179773006660 Protein of unknown function (DUF419); Region: DUF419; cl15265 1179773006661 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1179773006662 PhoD-like phosphatase; Region: PhoD; pfam09423 1179773006663 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773006664 putative active site [active] 1179773006665 putative metal binding site [ion binding]; other site 1179773006666 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773006667 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773006668 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773006669 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1179773006670 Histidine kinase; Region: HisKA_3; pfam07730 1179773006671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773006672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773006673 ATP binding site [chemical binding]; other site 1179773006674 Mg2+ binding site [ion binding]; other site 1179773006675 G-X-G motif; other site 1179773006676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773006677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773006678 active site 1179773006679 phosphorylation site [posttranslational modification] 1179773006680 intermolecular recognition site; other site 1179773006681 dimerization interface [polypeptide binding]; other site 1179773006682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773006683 DNA binding residues [nucleotide binding] 1179773006684 dimerization interface [polypeptide binding]; other site 1179773006685 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1179773006686 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1179773006687 active site 1179773006688 substrate binding site [chemical binding]; other site 1179773006689 Mg2+ binding site [ion binding]; other site 1179773006690 hypothetical protein; Provisional; Region: PRK07588 1179773006691 hypothetical protein; Provisional; Region: PRK07236 1179773006692 hypothetical protein; Provisional; Region: PRK07236 1179773006693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006695 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773006696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773006697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773006698 DNA binding residues [nucleotide binding] 1179773006699 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773006700 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773006701 MbtH-like protein; Region: MbtH; pfam03621 1179773006702 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1179773006703 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773006704 FAD binding pocket [chemical binding]; other site 1179773006705 FAD binding motif [chemical binding]; other site 1179773006706 phosphate binding motif [ion binding]; other site 1179773006707 NAD binding pocket [chemical binding]; other site 1179773006708 enterobactin exporter EntS; Provisional; Region: PRK10489 1179773006709 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006710 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006711 peptide synthase; Provisional; Region: PRK12467 1179773006712 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773006713 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006714 acyl-activating enzyme (AAE) consensus motif; other site 1179773006715 AMP binding site [chemical binding]; other site 1179773006716 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006717 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773006718 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006719 acyl-activating enzyme (AAE) consensus motif; other site 1179773006720 AMP binding site [chemical binding]; other site 1179773006721 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006722 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773006723 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006724 acyl-activating enzyme (AAE) consensus motif; other site 1179773006725 AMP binding site [chemical binding]; other site 1179773006726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006727 Condensation domain; Region: Condensation; pfam00668 1179773006728 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773006729 Condensation domain; Region: Condensation; pfam00668 1179773006730 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773006731 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006732 acyl-activating enzyme (AAE) consensus motif; other site 1179773006733 AMP binding site [chemical binding]; other site 1179773006734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006735 Condensation domain; Region: Condensation; pfam00668 1179773006736 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773006737 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1179773006738 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773006739 acyl-activating enzyme (AAE) consensus motif; other site 1179773006740 AMP binding site [chemical binding]; other site 1179773006741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773006742 Condensation domain; Region: Condensation; pfam00668 1179773006743 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773006744 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773006745 acyl-activating enzyme (AAE) consensus motif; other site 1179773006746 active site 1179773006747 AMP binding site [chemical binding]; other site 1179773006748 CoA binding site [chemical binding]; other site 1179773006749 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1179773006750 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1179773006751 siderophore binding site; other site 1179773006752 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773006753 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1179773006754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773006755 ABC-ATPase subunit interface; other site 1179773006756 dimer interface [polypeptide binding]; other site 1179773006757 putative PBP binding regions; other site 1179773006758 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1179773006759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773006760 ABC-ATPase subunit interface; other site 1179773006761 dimer interface [polypeptide binding]; other site 1179773006762 putative PBP binding regions; other site 1179773006763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773006764 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1179773006765 NAD(P) binding site [chemical binding]; other site 1179773006766 active site 1179773006767 isochorismate synthase DhbC; Validated; Region: PRK06923 1179773006768 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1179773006769 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1179773006770 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1179773006771 acyl-activating enzyme (AAE) consensus motif; other site 1179773006772 active site 1179773006773 AMP binding site [chemical binding]; other site 1179773006774 substrate binding site [chemical binding]; other site 1179773006775 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773006776 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773006777 catalytic triad [active] 1179773006778 conserved cis-peptide bond; other site 1179773006779 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1179773006780 HNH endonuclease; Region: HNH_2; pfam13391 1179773006781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773006782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773006783 dimer interface [polypeptide binding]; other site 1179773006784 conserved gate region; other site 1179773006785 putative PBP binding loops; other site 1179773006786 ABC-ATPase subunit interface; other site 1179773006787 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1179773006788 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1179773006789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773006790 ABC-ATPase subunit interface; other site 1179773006791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773006792 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1179773006793 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1179773006794 Walker A/P-loop; other site 1179773006795 ATP binding site [chemical binding]; other site 1179773006796 Q-loop/lid; other site 1179773006797 ABC transporter signature motif; other site 1179773006798 Walker B; other site 1179773006799 D-loop; other site 1179773006800 H-loop/switch region; other site 1179773006801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773006802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773006803 active site 1179773006804 phosphorylation site [posttranslational modification] 1179773006805 intermolecular recognition site; other site 1179773006806 dimerization interface [polypeptide binding]; other site 1179773006807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773006808 DNA binding site [nucleotide binding] 1179773006809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773006810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773006811 dimer interface [polypeptide binding]; other site 1179773006812 phosphorylation site [posttranslational modification] 1179773006813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1179773006814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773006815 dimerization interface [polypeptide binding]; other site 1179773006816 putative DNA binding site [nucleotide binding]; other site 1179773006817 putative Zn2+ binding site [ion binding]; other site 1179773006818 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773006819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1179773006820 Transcription elongation factor Spt4; Region: Spt4; cl12033 1179773006821 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773006822 non-specific DNA binding site [nucleotide binding]; other site 1179773006823 salt bridge; other site 1179773006824 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006825 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773006826 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773006827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006829 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1179773006830 MgtC family; Region: MgtC; pfam02308 1179773006831 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1179773006832 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1179773006833 glutaminase active site [active] 1179773006834 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1179773006835 dimer interface [polypeptide binding]; other site 1179773006836 active site 1179773006837 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1179773006838 dimer interface [polypeptide binding]; other site 1179773006839 active site 1179773006840 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1179773006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773006842 putative substrate translocation pore; other site 1179773006843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773006844 Coenzyme A binding pocket [chemical binding]; other site 1179773006845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773006846 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 1179773006847 putative heme binding site [chemical binding]; other site 1179773006848 putative substrate binding site [chemical binding]; other site 1179773006849 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1179773006850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773006851 hypothetical protein; Provisional; Region: PRK08201 1179773006852 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773006853 metal binding site [ion binding]; metal-binding site 1179773006854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773006855 dimerization interface [polypeptide binding]; other site 1179773006856 putative DNA binding site [nucleotide binding]; other site 1179773006857 putative Zn2+ binding site [ion binding]; other site 1179773006858 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773006859 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1179773006860 catalytic triad [active] 1179773006861 conserved cis-peptide bond; other site 1179773006862 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1179773006863 active site 1179773006864 catalytic triad [active] 1179773006865 oxyanion hole [active] 1179773006866 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1179773006867 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1179773006868 DNA binding residues [nucleotide binding] 1179773006869 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1179773006870 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1179773006871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1179773006872 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1179773006873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773006874 dimer interface [polypeptide binding]; other site 1179773006875 conserved gate region; other site 1179773006876 putative PBP binding loops; other site 1179773006877 ABC-ATPase subunit interface; other site 1179773006878 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1179773006879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773006880 Walker A/P-loop; other site 1179773006881 ATP binding site [chemical binding]; other site 1179773006882 Q-loop/lid; other site 1179773006883 ABC transporter signature motif; other site 1179773006884 Walker B; other site 1179773006885 D-loop; other site 1179773006886 H-loop/switch region; other site 1179773006887 TOBE domain; Region: TOBE; pfam03459 1179773006888 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1179773006889 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1179773006890 NAD-dependent deacetylase; Provisional; Region: PRK00481 1179773006891 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1179773006892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006894 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773006895 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773006896 DNA binding residues [nucleotide binding] 1179773006897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773006898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773006899 putative substrate translocation pore; other site 1179773006900 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1179773006901 Peptidase family M23; Region: Peptidase_M23; pfam01551 1179773006902 Bacterial SH3 domain; Region: SH3_3; cl17532 1179773006903 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1179773006904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773006905 DNA binding residues [nucleotide binding] 1179773006906 dimer interface [polypeptide binding]; other site 1179773006907 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1179773006908 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1179773006909 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1179773006910 apolar tunnel; other site 1179773006911 heme binding site [chemical binding]; other site 1179773006912 dimerization interface [polypeptide binding]; other site 1179773006913 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1179773006914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006915 WHG domain; Region: WHG; pfam13305 1179773006916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773006917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773006918 active site 1179773006919 catalytic tetrad [active] 1179773006920 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1179773006921 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773006922 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773006923 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1179773006924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773006925 dimer interface [polypeptide binding]; other site 1179773006926 active site 1179773006927 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1179773006928 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1179773006929 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1179773006930 hydrophobic ligand binding site; other site 1179773006931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773006932 salt bridge; other site 1179773006933 non-specific DNA binding site [nucleotide binding]; other site 1179773006934 sequence-specific DNA binding site [nucleotide binding]; other site 1179773006935 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773006936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773006937 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773006938 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773006939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773006940 catalytic residue [active] 1179773006941 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1179773006942 putative homotetramer interface [polypeptide binding]; other site 1179773006943 putative homodimer interface [polypeptide binding]; other site 1179773006944 putative allosteric switch controlling residues; other site 1179773006945 putative metal binding site [ion binding]; other site 1179773006946 putative homodimer-homodimer interface [polypeptide binding]; other site 1179773006947 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1179773006948 metal-binding site [ion binding] 1179773006949 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1179773006950 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1179773006951 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1179773006952 metal-binding site [ion binding] 1179773006953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1179773006954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773006955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773006956 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1179773006957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773006958 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773006959 DNA binding site [nucleotide binding] 1179773006960 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773006961 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1179773006962 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1179773006963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773006964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773006965 active site 1179773006966 ATP binding site [chemical binding]; other site 1179773006967 substrate binding site [chemical binding]; other site 1179773006968 activation loop (A-loop); other site 1179773006969 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1179773006970 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1179773006971 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1179773006972 substrate binding pocket [chemical binding]; other site 1179773006973 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1179773006974 B12 binding site [chemical binding]; other site 1179773006975 cobalt ligand [ion binding]; other site 1179773006976 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1179773006977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1179773006978 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1179773006979 D-glutamate deacylase; Validated; Region: PRK09061 1179773006980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773006981 active site 1179773006982 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773006983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773006984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773006985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773006986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773006987 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773006988 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773006989 Walker A/P-loop; other site 1179773006990 ATP binding site [chemical binding]; other site 1179773006991 Q-loop/lid; other site 1179773006992 ABC transporter signature motif; other site 1179773006993 Walker B; other site 1179773006994 D-loop; other site 1179773006995 H-loop/switch region; other site 1179773006996 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773006997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773006998 ABC transporter; Region: ABC_tran; pfam00005 1179773006999 Q-loop/lid; other site 1179773007000 ABC transporter signature motif; other site 1179773007001 Walker B; other site 1179773007002 D-loop; other site 1179773007003 H-loop/switch region; other site 1179773007004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773007005 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773007006 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1179773007007 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773007008 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773007009 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773007010 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1179773007011 hypothetical protein; Provisional; Region: PRK07338 1179773007012 metal binding site [ion binding]; metal-binding site 1179773007013 dimer interface [polypeptide binding]; other site 1179773007014 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773007015 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1179773007016 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1179773007017 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1179773007018 active site 1179773007019 octamer interface [polypeptide binding]; other site 1179773007020 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773007021 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773007022 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773007023 CoenzymeA binding site [chemical binding]; other site 1179773007024 subunit interaction site [polypeptide binding]; other site 1179773007025 PHB binding site; other site 1179773007026 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1179773007027 SpoOM protein; Region: Spo0M; pfam07070 1179773007028 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773007029 AAA domain; Region: AAA_18; pfam13238 1179773007030 active site 1179773007031 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1179773007032 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1179773007033 active site 1179773007034 Zn binding site [ion binding]; other site 1179773007035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773007036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773007037 Walker A/P-loop; other site 1179773007038 ATP binding site [chemical binding]; other site 1179773007039 Q-loop/lid; other site 1179773007040 ABC transporter signature motif; other site 1179773007041 Walker B; other site 1179773007042 D-loop; other site 1179773007043 H-loop/switch region; other site 1179773007044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773007045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773007046 Histidine kinase; Region: HisKA_3; pfam07730 1179773007047 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773007048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007050 active site 1179773007051 phosphorylation site [posttranslational modification] 1179773007052 intermolecular recognition site; other site 1179773007053 dimerization interface [polypeptide binding]; other site 1179773007054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007055 DNA binding residues [nucleotide binding] 1179773007056 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1179773007057 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773007058 Domain of unknown function DUF11; Region: DUF11; pfam01345 1179773007059 Domain of unknown function DUF11; Region: DUF11; pfam01345 1179773007060 Domain of unknown function DUF11; Region: DUF11; pfam01345 1179773007061 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1179773007062 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773007063 active site 1179773007064 metal binding site [ion binding]; metal-binding site 1179773007065 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773007066 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773007067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007069 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1179773007070 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773007071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773007072 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773007073 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773007074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007076 active site 1179773007077 phosphorylation site [posttranslational modification] 1179773007078 intermolecular recognition site; other site 1179773007079 dimerization interface [polypeptide binding]; other site 1179773007080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007081 DNA binding residues [nucleotide binding] 1179773007082 dimerization interface [polypeptide binding]; other site 1179773007083 Putative sensor; Region: Sensor; pfam13796 1179773007084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773007085 Histidine kinase; Region: HisKA_3; pfam07730 1179773007086 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1179773007087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773007088 substrate binding site [chemical binding]; other site 1179773007089 oxyanion hole (OAH) forming residues; other site 1179773007090 trimer interface [polypeptide binding]; other site 1179773007091 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1179773007092 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1179773007093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773007094 DNA binding residues [nucleotide binding] 1179773007095 Cupin domain; Region: Cupin_2; pfam07883 1179773007096 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773007097 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1179773007098 Thioredoxin; Region: Thioredoxin_4; pfam13462 1179773007099 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1179773007100 putative active site [active] 1179773007101 redox center [active] 1179773007102 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 1179773007103 putative hydrophobic ligand binding site [chemical binding]; other site 1179773007104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773007105 NAD(P) binding site [chemical binding]; other site 1179773007106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773007107 active site 1179773007108 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1179773007109 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773007110 Integrase core domain; Region: rve; pfam00665 1179773007111 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773007112 AAA domain; Region: AAA_14; pfam13173 1179773007113 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1179773007114 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773007115 ribonuclease; Region: Ribonuclease; pfam00545 1179773007116 active site 1179773007117 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773007118 DNA binding residues [nucleotide binding] 1179773007119 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1179773007120 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1179773007121 putative catalytic site [active] 1179773007122 metal binding site A [ion binding]; metal-binding site 1179773007123 phosphate binding site [ion binding]; other site 1179773007124 metal binding site C [ion binding]; metal-binding site 1179773007125 metal binding site B [ion binding]; metal-binding site 1179773007126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773007127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773007128 Coenzyme A binding pocket [chemical binding]; other site 1179773007129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773007130 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1179773007131 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1179773007132 catalytic triad [active] 1179773007133 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773007134 active site 1179773007135 catalytic residues [active] 1179773007136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773007137 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773007138 AAA ATPase domain; Region: AAA_16; pfam13191 1179773007139 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773007140 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773007141 structural tetrad; other site 1179773007142 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773007143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773007144 structural tetrad; other site 1179773007145 GAF domain; Region: GAF; cl17456 1179773007146 GAF domain; Region: GAF_2; pfam13185 1179773007147 ANTAR domain; Region: ANTAR; pfam03861 1179773007148 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773007149 anti sigma factor interaction site; other site 1179773007150 regulatory phosphorylation site [posttranslational modification]; other site 1179773007151 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1179773007152 putative hydrophobic ligand binding site [chemical binding]; other site 1179773007153 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 1179773007154 cofactor binding site; other site 1179773007155 metal binding site [ion binding]; metal-binding site 1179773007156 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 1179773007157 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 1179773007158 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1179773007159 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1179773007160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773007161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773007162 DNA binding residues [nucleotide binding] 1179773007163 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1179773007164 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1179773007165 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1179773007166 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773007167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773007168 active site 1179773007169 DNA binding site [nucleotide binding] 1179773007170 Int/Topo IB signature motif; other site 1179773007171 Helix-turn-helix domain; Region: HTH_17; pfam12728 1179773007172 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773007173 DNA-binding site [nucleotide binding]; DNA binding site 1179773007174 RNA-binding motif; other site 1179773007175 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773007176 DNA-binding site [nucleotide binding]; DNA binding site 1179773007177 RNA-binding motif; other site 1179773007178 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773007179 DNA-binding site [nucleotide binding]; DNA binding site 1179773007180 RNA-binding motif; other site 1179773007181 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773007182 DNA-binding site [nucleotide binding]; DNA binding site 1179773007183 RNA-binding motif; other site 1179773007184 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1179773007185 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1179773007186 Integrase core domain; Region: rve; pfam00665 1179773007187 Integrase core domain; Region: rve_3; pfam13683 1179773007188 AAA ATPase domain; Region: AAA_16; pfam13191 1179773007189 NB-ARC domain; Region: NB-ARC; pfam00931 1179773007190 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1179773007191 conserved cys residue [active] 1179773007192 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773007193 homotrimer interaction site [polypeptide binding]; other site 1179773007194 putative active site [active] 1179773007195 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773007196 MarR family; Region: MarR; pfam01047 1179773007197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007199 DNA binding residues [nucleotide binding] 1179773007200 dimerization interface [polypeptide binding]; other site 1179773007201 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1179773007202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007204 hypothetical protein; Provisional; Region: PRK07236 1179773007205 hypothetical protein; Provisional; Region: PRK07588 1179773007206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773007207 Cytochrome P450; Region: p450; cl12078 1179773007208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773007209 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1179773007210 putative NAD(P) binding site [chemical binding]; other site 1179773007211 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1179773007212 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773007213 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773007214 RHS Repeat; Region: RHS_repeat; pfam05593 1179773007215 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1179773007216 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773007217 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773007218 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773007219 protein-splicing catalytic site; other site 1179773007220 thioester formation/cholesterol transfer; other site 1179773007221 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1179773007222 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1179773007223 NmrA-like family; Region: NmrA; pfam05368 1179773007224 NADP binding site [chemical binding]; other site 1179773007225 active site 1179773007226 regulatory binding site [polypeptide binding]; other site 1179773007227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773007230 dimer interface [polypeptide binding]; other site 1179773007231 phosphorylation site [posttranslational modification] 1179773007232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007233 ATP binding site [chemical binding]; other site 1179773007234 Mg2+ binding site [ion binding]; other site 1179773007235 G-X-G motif; other site 1179773007236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773007237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007238 active site 1179773007239 phosphorylation site [posttranslational modification] 1179773007240 intermolecular recognition site; other site 1179773007241 dimerization interface [polypeptide binding]; other site 1179773007242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773007243 DNA binding site [nucleotide binding] 1179773007244 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773007245 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773007246 Berberine and berberine like; Region: BBE; pfam08031 1179773007247 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773007248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773007249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773007250 active site 1179773007251 catalytic tetrad [active] 1179773007252 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1179773007253 hydrophobic ligand binding site; other site 1179773007254 YceI-like domain; Region: YceI; cl01001 1179773007255 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1179773007256 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1179773007257 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1179773007258 putative active site [active] 1179773007259 putative metal binding site [ion binding]; other site 1179773007260 HAMP domain; Region: HAMP; pfam00672 1179773007261 dimerization interface [polypeptide binding]; other site 1179773007262 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1179773007263 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 1179773007264 NlpC/P60 family; Region: NLPC_P60; cl17555 1179773007265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773007266 DNA-binding site [nucleotide binding]; DNA binding site 1179773007267 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1179773007268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773007269 Walker A/P-loop; other site 1179773007270 ATP binding site [chemical binding]; other site 1179773007271 Q-loop/lid; other site 1179773007272 ABC transporter signature motif; other site 1179773007273 Walker B; other site 1179773007274 D-loop; other site 1179773007275 H-loop/switch region; other site 1179773007276 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1179773007277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773007278 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773007279 active site 1179773007280 metal binding site [ion binding]; metal-binding site 1179773007281 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1179773007282 Predicted transcriptional regulators [Transcription]; Region: COG1378 1179773007283 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1179773007284 PLD-like domain; Region: PLDc_2; pfam13091 1179773007285 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1179773007286 DNA binding residues [nucleotide binding] 1179773007287 dimerization interface [polypeptide binding]; other site 1179773007288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773007289 non-specific DNA binding site [nucleotide binding]; other site 1179773007290 salt bridge; other site 1179773007291 sequence-specific DNA binding site [nucleotide binding]; other site 1179773007292 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773007293 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773007294 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773007295 calcium binding site 2 [ion binding]; other site 1179773007296 active site 1179773007297 catalytic triad [active] 1179773007298 calcium binding site 1 [ion binding]; other site 1179773007299 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773007300 cleavage site 1179773007301 active site 1179773007302 substrate binding sites [chemical binding]; other site 1179773007303 Putative Ig domain; Region: He_PIG; pfam05345 1179773007304 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773007305 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773007306 RHS Repeat; Region: RHS_repeat; pfam05593 1179773007307 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773007308 RHS Repeat; Region: RHS_repeat; pfam05593 1179773007309 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773007310 RHS Repeat; Region: RHS_repeat; cl11982 1179773007311 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773007312 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773007313 protein-splicing catalytic site; other site 1179773007314 thioester formation/cholesterol transfer; other site 1179773007315 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1179773007316 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1179773007317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773007318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773007319 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773007320 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1179773007321 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773007322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773007323 dimer interface [polypeptide binding]; other site 1179773007324 conserved gate region; other site 1179773007325 putative PBP binding loops; other site 1179773007326 ABC-ATPase subunit interface; other site 1179773007327 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773007328 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773007329 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773007330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773007331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773007332 active site 1179773007333 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 1179773007334 active site 1179773007335 Zn binding site [ion binding]; other site 1179773007336 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773007337 Ligand Binding Site [chemical binding]; other site 1179773007338 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773007339 active site 1179773007340 ATP binding site [chemical binding]; other site 1179773007341 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1179773007342 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1179773007343 metal ion-dependent adhesion site (MIDAS); other site 1179773007344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773007345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773007346 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1179773007347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773007348 active site 1179773007349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773007350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773007351 NAD(P) binding site [chemical binding]; other site 1179773007352 active site 1179773007353 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773007354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773007355 NAD(P) binding site [chemical binding]; other site 1179773007356 active site 1179773007357 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1179773007358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773007359 NAD(P) binding site [chemical binding]; other site 1179773007360 active site 1179773007361 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1179773007362 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1179773007363 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1179773007364 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1179773007365 heme binding site [chemical binding]; other site 1179773007366 substrate binding site [chemical binding]; other site 1179773007367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773007368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007369 ATP binding site [chemical binding]; other site 1179773007370 Mg2+ binding site [ion binding]; other site 1179773007371 G-X-G motif; other site 1179773007372 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1179773007373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007374 active site 1179773007375 phosphorylation site [posttranslational modification] 1179773007376 intermolecular recognition site; other site 1179773007377 dimerization interface [polypeptide binding]; other site 1179773007378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007379 DNA binding residues [nucleotide binding] 1179773007380 dimerization interface [polypeptide binding]; other site 1179773007381 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1179773007382 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773007383 DNA binding site [nucleotide binding] 1179773007384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773007385 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773007386 putative substrate translocation pore; other site 1179773007387 argininosuccinate synthase; Validated; Region: PRK05370 1179773007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773007389 S-adenosylmethionine binding site [chemical binding]; other site 1179773007390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007392 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773007393 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1179773007394 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1179773007395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773007396 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1179773007397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773007398 dimer interface [polypeptide binding]; other site 1179773007399 conserved gate region; other site 1179773007400 ABC-ATPase subunit interface; other site 1179773007401 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1179773007402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773007403 Walker A/P-loop; other site 1179773007404 ATP binding site [chemical binding]; other site 1179773007405 Q-loop/lid; other site 1179773007406 ABC transporter signature motif; other site 1179773007407 Walker B; other site 1179773007408 D-loop; other site 1179773007409 H-loop/switch region; other site 1179773007410 TOBE domain; Region: TOBE_2; pfam08402 1179773007411 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1179773007412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773007413 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773007414 active site 1179773007415 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1179773007416 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1179773007417 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1179773007418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007420 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1179773007421 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1179773007422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773007423 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773007424 Walker A/P-loop; other site 1179773007425 ATP binding site [chemical binding]; other site 1179773007426 Q-loop/lid; other site 1179773007427 ABC transporter signature motif; other site 1179773007428 Walker B; other site 1179773007429 D-loop; other site 1179773007430 H-loop/switch region; other site 1179773007431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773007432 Histidine kinase; Region: HisKA_3; pfam07730 1179773007433 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773007434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007435 ATP binding site [chemical binding]; other site 1179773007436 Mg2+ binding site [ion binding]; other site 1179773007437 G-X-G motif; other site 1179773007438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007440 active site 1179773007441 phosphorylation site [posttranslational modification] 1179773007442 intermolecular recognition site; other site 1179773007443 dimerization interface [polypeptide binding]; other site 1179773007444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007445 DNA binding residues [nucleotide binding] 1179773007446 dimerization interface [polypeptide binding]; other site 1179773007447 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1179773007448 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1179773007449 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1179773007450 nucleoside/Zn binding site; other site 1179773007451 dimer interface [polypeptide binding]; other site 1179773007452 catalytic motif [active] 1179773007453 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1179773007454 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1179773007455 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1179773007456 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1179773007457 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1179773007458 active site 1179773007459 putative substrate binding pocket [chemical binding]; other site 1179773007460 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1179773007461 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1179773007462 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1179773007463 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773007464 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1179773007465 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1179773007466 active site 1179773007467 homotetramer interface [polypeptide binding]; other site 1179773007468 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1179773007469 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773007470 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1179773007471 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1179773007472 NB-ARC domain; Region: NB-ARC; pfam00931 1179773007473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007474 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1179773007475 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1179773007476 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1179773007477 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773007478 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773007479 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1179773007480 NB-ARC domain; Region: NB-ARC; pfam00931 1179773007481 Walker A motif; other site 1179773007482 ATP binding site [chemical binding]; other site 1179773007483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773007484 binding surface 1179773007485 TPR motif; other site 1179773007486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773007489 binding surface 1179773007490 TPR motif; other site 1179773007491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007492 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1179773007493 Nitrate and nitrite sensing; Region: NIT; pfam08376 1179773007494 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773007495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007496 ATP binding site [chemical binding]; other site 1179773007497 Mg2+ binding site [ion binding]; other site 1179773007498 G-X-G motif; other site 1179773007499 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1179773007500 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773007501 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1179773007502 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1179773007503 G1 box; other site 1179773007504 GTP/Mg2+ binding site [chemical binding]; other site 1179773007505 G2 box; other site 1179773007506 Switch I region; other site 1179773007507 G3 box; other site 1179773007508 Switch II region; other site 1179773007509 G4 box; other site 1179773007510 G5 box; other site 1179773007511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1179773007512 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1179773007513 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 1179773007514 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1179773007515 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773007516 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773007517 ethanolamine permease; Region: 2A0305; TIGR00908 1179773007518 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1179773007519 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1179773007520 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1179773007521 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1179773007522 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1179773007523 catalytic triad [active] 1179773007524 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773007525 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773007526 NAD(P) binding site [chemical binding]; other site 1179773007527 catalytic residues [active] 1179773007528 short chain dehydrogenase; Provisional; Region: PRK06057 1179773007529 classical (c) SDRs; Region: SDR_c; cd05233 1179773007530 NAD(P) binding site [chemical binding]; other site 1179773007531 active site 1179773007532 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773007533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773007534 DNA-binding site [nucleotide binding]; DNA binding site 1179773007535 FCD domain; Region: FCD; pfam07729 1179773007536 Lamin Tail Domain; Region: LTD; pfam00932 1179773007537 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1179773007538 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1179773007539 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1179773007540 active site 1179773007541 dimer interface [polypeptide binding]; other site 1179773007542 motif 1; other site 1179773007543 motif 2; other site 1179773007544 motif 3; other site 1179773007545 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1179773007546 anticodon binding site; other site 1179773007547 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1179773007548 nucleotide binding site/active site [active] 1179773007549 HIT family signature motif; other site 1179773007550 catalytic residue [active] 1179773007551 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1179773007552 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1179773007553 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1179773007554 putative acyl-acceptor binding pocket; other site 1179773007555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773007556 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773007557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1179773007558 nudix motif; other site 1179773007559 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 1179773007560 active site 1179773007561 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1179773007562 pentamer interface [polypeptide binding]; other site 1179773007563 dodecaamer interface [polypeptide binding]; other site 1179773007564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773007565 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1179773007566 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773007567 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1179773007568 phenylhydantoinase; Validated; Region: PRK08323 1179773007569 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1179773007570 tetramer interface [polypeptide binding]; other site 1179773007571 active site 1179773007572 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1179773007573 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1179773007574 active site 1179773007575 catalytic triad [active] 1179773007576 dimer interface [polypeptide binding]; other site 1179773007577 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1179773007578 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1179773007579 Na binding site [ion binding]; other site 1179773007580 putative substrate binding site [chemical binding]; other site 1179773007581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773007582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773007583 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773007584 substrate binding pocket [chemical binding]; other site 1179773007585 dimerization interface [polypeptide binding]; other site 1179773007586 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1179773007587 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773007588 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1179773007589 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773007590 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1179773007591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773007592 inhibitor-cofactor binding pocket; inhibition site 1179773007593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773007594 catalytic residue [active] 1179773007595 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1179773007596 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1179773007597 tetrameric interface [polypeptide binding]; other site 1179773007598 NAD binding site [chemical binding]; other site 1179773007599 catalytic residues [active] 1179773007600 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1179773007601 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1179773007602 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773007603 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773007604 elongation factor G; Reviewed; Region: PRK12740 1179773007605 G1 box; other site 1179773007606 GTP/Mg2+ binding site [chemical binding]; other site 1179773007607 G2 box; other site 1179773007608 Switch I region; other site 1179773007609 G3 box; other site 1179773007610 Switch II region; other site 1179773007611 G4 box; other site 1179773007612 G5 box; other site 1179773007613 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1179773007614 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1179773007615 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1179773007616 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1179773007617 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773007618 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1179773007619 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1179773007620 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1179773007621 active site 1179773007622 multimer interface [polypeptide binding]; other site 1179773007623 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1179773007624 putative active site [active] 1179773007625 homotetrameric interface [polypeptide binding]; other site 1179773007626 metal binding site [ion binding]; metal-binding site 1179773007627 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773007628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773007629 non-specific DNA binding site [nucleotide binding]; other site 1179773007630 salt bridge; other site 1179773007631 sequence-specific DNA binding site [nucleotide binding]; other site 1179773007632 AzlC protein; Region: AzlC; pfam03591 1179773007633 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773007634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773007635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773007636 DNA binding residues [nucleotide binding] 1179773007637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773007638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773007639 active site 1179773007640 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773007641 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773007642 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773007643 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1179773007644 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773007645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773007646 catalytic residue [active] 1179773007647 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1179773007648 Spore germination protein; Region: Spore_permease; cl17796 1179773007649 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1179773007650 predicted active site [active] 1179773007651 catalytic triad [active] 1179773007652 hypothetical protein; Validated; Region: PRK00110 1179773007653 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773007654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773007655 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1179773007656 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1179773007657 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773007658 TIGR03086 family protein; Region: TIGR03086 1179773007659 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1179773007660 POT family; Region: PTR2; cl17359 1179773007661 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773007662 Cytochrome P450; Region: p450; cl12078 1179773007663 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773007664 Cytochrome P450; Region: p450; cl12078 1179773007665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007667 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773007668 Predicted ATPase [General function prediction only]; Region: COG3903 1179773007669 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1179773007670 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773007671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007673 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1179773007674 Ca binding site [ion binding]; other site 1179773007675 Ca binding site (active) [ion binding]; other site 1179773007676 ligand binding site [chemical binding]; other site 1179773007677 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1179773007678 Ca binding site [ion binding]; other site 1179773007679 ligand binding site [chemical binding]; other site 1179773007680 Ca binding site (active) [ion binding]; other site 1179773007681 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773007682 Interdomain contacts; other site 1179773007683 Cytokine receptor motif; other site 1179773007684 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773007685 Interdomain contacts; other site 1179773007686 Cytokine receptor motif; other site 1179773007687 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1179773007688 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1179773007689 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1179773007690 substrate binding site [chemical binding]; other site 1179773007691 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773007692 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1179773007693 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1179773007694 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1179773007695 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1179773007696 putative active site [active] 1179773007697 putative dimer interface [polypeptide binding]; other site 1179773007698 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1179773007699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773007700 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1179773007701 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773007702 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773007703 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1179773007704 TIR domain; Region: TIR_2; pfam13676 1179773007705 aconitate hydratase; Validated; Region: PRK09277 1179773007706 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1179773007707 substrate binding site [chemical binding]; other site 1179773007708 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1179773007709 ligand binding site [chemical binding]; other site 1179773007710 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1179773007711 substrate binding site [chemical binding]; other site 1179773007712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773007713 Walker A/P-loop; other site 1179773007714 ATP binding site [chemical binding]; other site 1179773007715 Q-loop/lid; other site 1179773007716 ABC transporter signature motif; other site 1179773007717 Walker B; other site 1179773007718 D-loop; other site 1179773007719 hypothetical protein; Provisional; Region: PRK06184 1179773007720 hypothetical protein; Provisional; Region: PRK07236 1179773007721 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773007722 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1179773007723 NAD+ binding site [chemical binding]; other site 1179773007724 substrate binding site [chemical binding]; other site 1179773007725 Zn binding site [ion binding]; other site 1179773007726 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1179773007727 active site 1179773007728 zinc binding site [ion binding]; other site 1179773007729 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1179773007730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773007731 acyl-activating enzyme (AAE) consensus motif; other site 1179773007732 AMP binding site [chemical binding]; other site 1179773007733 active site 1179773007734 CoA binding site [chemical binding]; other site 1179773007735 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773007736 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773007737 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773007738 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1179773007739 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1179773007740 active site 1179773007741 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773007742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773007743 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773007744 hypothetical protein; Provisional; Region: PRK13685 1179773007745 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1179773007746 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1179773007747 metal ion-dependent adhesion site (MIDAS); other site 1179773007748 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1179773007749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1179773007750 dimer interface [polypeptide binding]; other site 1179773007751 phosphorylation site [posttranslational modification] 1179773007752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773007753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007754 Mg2+ binding site [ion binding]; other site 1179773007755 G-X-G motif; other site 1179773007756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773007757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007758 active site 1179773007759 phosphorylation site [posttranslational modification] 1179773007760 intermolecular recognition site; other site 1179773007761 dimerization interface [polypeptide binding]; other site 1179773007762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773007763 DNA binding site [nucleotide binding] 1179773007764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773007765 GAF domain; Region: GAF; pfam01590 1179773007766 ANTAR domain; Region: ANTAR; pfam03861 1179773007767 hypothetical protein; Provisional; Region: PRK04233 1179773007768 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 1179773007769 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773007770 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773007771 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1179773007772 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1179773007773 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1179773007774 NAD(P) binding site [chemical binding]; other site 1179773007775 homotetramer interface [polypeptide binding]; other site 1179773007776 homodimer interface [polypeptide binding]; other site 1179773007777 active site 1179773007778 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1179773007779 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1179773007780 NAD binding site [chemical binding]; other site 1179773007781 homotetramer interface [polypeptide binding]; other site 1179773007782 homodimer interface [polypeptide binding]; other site 1179773007783 substrate binding site [chemical binding]; other site 1179773007784 active site 1179773007785 ferrochelatase; Reviewed; Region: hemH; PRK00035 1179773007786 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1179773007787 C-terminal domain interface [polypeptide binding]; other site 1179773007788 active site 1179773007789 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1179773007790 active site 1179773007791 N-terminal domain interface [polypeptide binding]; other site 1179773007792 YcxB-like protein; Region: YcxB; pfam14317 1179773007793 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1179773007794 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1179773007795 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773007796 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1179773007797 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1179773007798 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1179773007799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773007800 metal ion-dependent adhesion site (MIDAS); other site 1179773007801 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773007802 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773007803 Cupin; Region: Cupin_6; pfam12852 1179773007804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773007805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773007806 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1179773007807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773007808 substrate binding site [chemical binding]; other site 1179773007809 oxyanion hole (OAH) forming residues; other site 1179773007810 trimer interface [polypeptide binding]; other site 1179773007811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773007812 DNA-binding site [nucleotide binding]; DNA binding site 1179773007813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773007815 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773007816 hypothetical protein; Validated; Region: PRK05868 1179773007817 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773007818 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1179773007819 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1179773007820 D-pathway; other site 1179773007821 Putative ubiquinol binding site [chemical binding]; other site 1179773007822 Low-spin heme (heme b) binding site [chemical binding]; other site 1179773007823 Putative water exit pathway; other site 1179773007824 Binuclear center (heme o3/CuB) [ion binding]; other site 1179773007825 K-pathway; other site 1179773007826 Putative proton exit pathway; other site 1179773007827 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1179773007828 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1179773007829 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773007830 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1179773007831 active site 1179773007832 HIGH motif; other site 1179773007833 nucleotide binding site [chemical binding]; other site 1179773007834 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773007835 active site 1179773007836 KMSKS motif; other site 1179773007837 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1179773007838 tRNA binding surface [nucleotide binding]; other site 1179773007839 anticodon binding site; other site 1179773007840 TIR domain; Region: TIR_2; pfam13676 1179773007841 NB-ARC domain; Region: NB-ARC; pfam00931 1179773007842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007843 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773007845 binding surface 1179773007846 TPR motif; other site 1179773007847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007848 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773007849 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773007850 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773007851 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773007852 calcium binding site 2 [ion binding]; other site 1179773007853 active site 1179773007854 catalytic triad [active] 1179773007855 calcium binding site 1 [ion binding]; other site 1179773007856 Putative Ig domain; Region: He_PIG; pfam05345 1179773007857 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773007858 Predicted transcriptional regulators [Transcription]; Region: COG1510 1179773007859 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773007860 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773007861 Walker A/P-loop; other site 1179773007862 ATP binding site [chemical binding]; other site 1179773007863 Q-loop/lid; other site 1179773007864 ABC transporter signature motif; other site 1179773007865 Walker B; other site 1179773007866 D-loop; other site 1179773007867 H-loop/switch region; other site 1179773007868 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1179773007869 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1179773007870 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1179773007871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773007872 dimerization interface [polypeptide binding]; other site 1179773007873 putative DNA binding site [nucleotide binding]; other site 1179773007874 putative Zn2+ binding site [ion binding]; other site 1179773007875 enterobactin exporter EntS; Provisional; Region: PRK10489 1179773007876 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1179773007877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773007878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773007879 putative substrate translocation pore; other site 1179773007880 PAC2 family; Region: PAC2; pfam09754 1179773007881 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1179773007882 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1179773007883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773007884 motif II; other site 1179773007885 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1179773007886 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1179773007887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773007888 Coenzyme A binding pocket [chemical binding]; other site 1179773007889 hypothetical protein; Provisional; Region: PRK06834 1179773007890 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773007891 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773007892 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773007893 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1179773007894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773007895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1179773007896 homodimer interface [polypeptide binding]; other site 1179773007897 putative metal binding site [ion binding]; other site 1179773007898 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1179773007899 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1179773007900 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1179773007901 active site 1179773007902 putative substrate binding region [chemical binding]; other site 1179773007903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1179773007904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007906 active site 1179773007907 phosphorylation site [posttranslational modification] 1179773007908 intermolecular recognition site; other site 1179773007909 dimerization interface [polypeptide binding]; other site 1179773007910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007911 DNA binding residues [nucleotide binding] 1179773007912 dimerization interface [polypeptide binding]; other site 1179773007913 Histidine kinase; Region: HisKA_3; pfam07730 1179773007914 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773007915 ATP binding site [chemical binding]; other site 1179773007916 Mg2+ binding site [ion binding]; other site 1179773007917 G-X-G motif; other site 1179773007918 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1179773007919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773007920 S-adenosylmethionine binding site [chemical binding]; other site 1179773007921 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1179773007922 proteasome ATPase; Region: pup_AAA; TIGR03689 1179773007923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773007924 Walker A motif; other site 1179773007925 ATP binding site [chemical binding]; other site 1179773007926 Walker B motif; other site 1179773007927 arginine finger; other site 1179773007928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007930 active site 1179773007931 phosphorylation site [posttranslational modification] 1179773007932 intermolecular recognition site; other site 1179773007933 dimerization interface [polypeptide binding]; other site 1179773007934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007935 DNA binding residues [nucleotide binding] 1179773007936 dimerization interface [polypeptide binding]; other site 1179773007937 Histidine kinase; Region: HisKA_3; pfam07730 1179773007938 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773007939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773007940 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1179773007941 Walker A/P-loop; other site 1179773007942 ATP binding site [chemical binding]; other site 1179773007943 Q-loop/lid; other site 1179773007944 ABC transporter signature motif; other site 1179773007945 Walker B; other site 1179773007946 D-loop; other site 1179773007947 H-loop/switch region; other site 1179773007948 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1179773007949 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773007950 active site 1179773007951 catalytic tetrad [active] 1179773007952 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1179773007953 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773007954 nudix motif; other site 1179773007955 FtsX-like permease family; Region: FtsX; pfam02687 1179773007956 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1179773007957 Pup-like protein; Region: Pup; pfam05639 1179773007958 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1179773007959 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1179773007960 active site 1179773007961 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1179773007962 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1179773007963 active site 1179773007964 MarR family; Region: MarR; pfam01047 1179773007965 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773007966 MarR family; Region: MarR_2; cl17246 1179773007967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1179773007968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773007969 Coenzyme A binding pocket [chemical binding]; other site 1179773007970 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1179773007971 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1179773007972 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1179773007973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773007974 dimerization interface [polypeptide binding]; other site 1179773007975 putative DNA binding site [nucleotide binding]; other site 1179773007976 putative Zn2+ binding site [ion binding]; other site 1179773007977 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1179773007978 putative hydrophobic ligand binding site [chemical binding]; other site 1179773007979 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1179773007980 putative hydrophobic ligand binding site [chemical binding]; other site 1179773007981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773007982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773007983 active site 1179773007984 phosphorylation site [posttranslational modification] 1179773007985 intermolecular recognition site; other site 1179773007986 dimerization interface [polypeptide binding]; other site 1179773007987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773007988 DNA binding residues [nucleotide binding] 1179773007989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773007990 Histidine kinase; Region: HisKA_3; pfam07730 1179773007991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773007992 ATP binding site [chemical binding]; other site 1179773007993 Mg2+ binding site [ion binding]; other site 1179773007994 G-X-G motif; other site 1179773007995 Domain of unknown function (DUF336); Region: DUF336; cl01249 1179773007996 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773007997 WYL domain; Region: WYL; pfam13280 1179773007998 WYL domain; Region: WYL; pfam13280 1179773007999 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1179773008000 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1179773008001 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1179773008002 diacylglycerol kinase; Reviewed; Region: PRK11914 1179773008003 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1179773008004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773008005 ATP binding site [chemical binding]; other site 1179773008006 putative Mg++ binding site [ion binding]; other site 1179773008007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773008008 nucleotide binding region [chemical binding]; other site 1179773008009 ATP-binding site [chemical binding]; other site 1179773008010 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1179773008011 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1179773008012 hypothetical protein; Provisional; Region: PRK01346 1179773008013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1179773008014 5'-3' exonuclease; Region: 53EXOc; smart00475 1179773008015 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1179773008016 active site 1179773008017 metal binding site 1 [ion binding]; metal-binding site 1179773008018 putative 5' ssDNA interaction site; other site 1179773008019 metal binding site 3; metal-binding site 1179773008020 metal binding site 2 [ion binding]; metal-binding site 1179773008021 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1179773008022 putative DNA binding site [nucleotide binding]; other site 1179773008023 putative metal binding site [ion binding]; other site 1179773008024 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1179773008025 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1179773008026 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1179773008027 active site 1179773008028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773008029 putative DNA binding site [nucleotide binding]; other site 1179773008030 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773008031 putative Zn2+ binding site [ion binding]; other site 1179773008032 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773008033 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1179773008034 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1179773008035 homodimer interface [polypeptide binding]; other site 1179773008036 substrate-cofactor binding pocket; other site 1179773008037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773008038 catalytic residue [active] 1179773008039 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1179773008040 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1179773008041 conserved cys residue [active] 1179773008042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773008043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773008044 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1179773008045 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1179773008046 conserved cys residue [active] 1179773008047 CHAT domain; Region: CHAT; cl17868 1179773008048 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008050 binding surface 1179773008051 TPR motif; other site 1179773008052 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1179773008053 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1179773008054 cleavage site 1179773008055 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1179773008056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773008057 catalytic residue [active] 1179773008058 Carboxylesterase family; Region: COesterase; pfam00135 1179773008059 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773008060 substrate binding pocket [chemical binding]; other site 1179773008061 catalytic triad [active] 1179773008062 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1179773008063 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1179773008064 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1179773008065 ATP binding site [chemical binding]; other site 1179773008066 Mg++ binding site [ion binding]; other site 1179773008067 motif III; other site 1179773008068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773008069 nucleotide binding region [chemical binding]; other site 1179773008070 ATP-binding site [chemical binding]; other site 1179773008071 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1179773008072 RNA binding site [nucleotide binding]; other site 1179773008073 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773008074 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773008075 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773008076 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773008077 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1179773008078 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773008079 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1179773008080 dimer interface [polypeptide binding]; other site 1179773008081 active site 1179773008082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773008083 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773008084 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773008085 active site 1179773008086 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773008087 active site 2 [active] 1179773008088 active site 1 [active] 1179773008089 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773008090 active site 2 [active] 1179773008091 active site 1 [active] 1179773008092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008093 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1179773008094 NAD(P) binding site [chemical binding]; other site 1179773008095 active site 1179773008096 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1179773008097 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1179773008098 putative catalytic residue [active] 1179773008099 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773008100 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1179773008101 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773008102 FtsX-like permease family; Region: FtsX; pfam02687 1179773008103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773008104 FtsX-like permease family; Region: FtsX; pfam02687 1179773008105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773008106 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773008107 Walker A/P-loop; other site 1179773008108 ATP binding site [chemical binding]; other site 1179773008109 Q-loop/lid; other site 1179773008110 ABC transporter signature motif; other site 1179773008111 Walker B; other site 1179773008112 D-loop; other site 1179773008113 H-loop/switch region; other site 1179773008114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773008115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773008116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773008117 dimerization interface [polypeptide binding]; other site 1179773008118 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 1179773008119 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773008120 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1179773008121 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1179773008122 dimer interface [polypeptide binding]; other site 1179773008123 active site 1179773008124 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773008125 catalytic residues [active] 1179773008126 substrate binding site [chemical binding]; other site 1179773008127 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1179773008128 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773008129 active site 1179773008130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773008131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773008132 active site 1179773008133 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1179773008134 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1179773008135 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1179773008136 NAD binding site [chemical binding]; other site 1179773008137 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1179773008138 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1179773008139 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1179773008140 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1179773008141 dimer interface [polypeptide binding]; other site 1179773008142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773008143 catalytic residue [active] 1179773008144 Condensation domain; Region: Condensation; pfam00668 1179773008145 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008146 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008147 acyl-activating enzyme (AAE) consensus motif; other site 1179773008148 AMP binding site [chemical binding]; other site 1179773008149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008150 Condensation domain; Region: Condensation; pfam00668 1179773008151 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773008152 Condensation domain; Region: Condensation; pfam00668 1179773008153 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008154 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008155 acyl-activating enzyme (AAE) consensus motif; other site 1179773008156 AMP binding site [chemical binding]; other site 1179773008157 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008158 Condensation domain; Region: Condensation; pfam00668 1179773008159 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008160 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008161 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008162 acyl-activating enzyme (AAE) consensus motif; other site 1179773008163 AMP binding site [chemical binding]; other site 1179773008164 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008165 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1179773008166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008167 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008168 acyl-activating enzyme (AAE) consensus motif; other site 1179773008169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008170 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773008171 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773008172 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773008173 Cytochrome P450; Region: p450; cl12078 1179773008174 MbtH-like protein; Region: MbtH; cl01279 1179773008175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773008176 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773008177 Walker A/P-loop; other site 1179773008178 ATP binding site [chemical binding]; other site 1179773008179 Q-loop/lid; other site 1179773008180 ABC transporter signature motif; other site 1179773008181 Walker B; other site 1179773008182 D-loop; other site 1179773008183 H-loop/switch region; other site 1179773008184 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1179773008185 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773008186 MbtH-like protein; Region: MbtH; cl01279 1179773008187 enterobactin exporter EntS; Provisional; Region: PRK10489 1179773008188 peptide synthase; Provisional; Region: PRK12316 1179773008189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008191 acyl-activating enzyme (AAE) consensus motif; other site 1179773008192 AMP binding site [chemical binding]; other site 1179773008193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008194 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773008195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008196 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008197 acyl-activating enzyme (AAE) consensus motif; other site 1179773008198 AMP binding site [chemical binding]; other site 1179773008199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008200 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008201 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008202 acyl-activating enzyme (AAE) consensus motif; other site 1179773008203 AMP binding site [chemical binding]; other site 1179773008204 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008205 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773008206 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008207 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008208 acyl-activating enzyme (AAE) consensus motif; other site 1179773008209 AMP binding site [chemical binding]; other site 1179773008210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008211 Condensation domain; Region: Condensation; pfam00668 1179773008212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008213 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008215 acyl-activating enzyme (AAE) consensus motif; other site 1179773008216 AMP binding site [chemical binding]; other site 1179773008217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008218 Condensation domain; Region: Condensation; pfam00668 1179773008219 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008220 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773008221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008222 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773008223 acyl-activating enzyme (AAE) consensus motif; other site 1179773008224 AMP binding site [chemical binding]; other site 1179773008225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008226 Condensation domain; Region: Condensation; pfam00668 1179773008227 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008228 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008229 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773008230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008231 Condensation domain; Region: Condensation; pfam00668 1179773008232 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008233 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1179773008234 Condensation domain; Region: Condensation; pfam00668 1179773008235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008236 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008237 acyl-activating enzyme (AAE) consensus motif; other site 1179773008238 AMP binding site [chemical binding]; other site 1179773008239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008240 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773008241 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773008242 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1179773008243 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773008244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1179773008245 synthetase active site [active] 1179773008246 NTP binding site [chemical binding]; other site 1179773008247 metal binding site [ion binding]; metal-binding site 1179773008248 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1179773008249 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773008250 MarR family; Region: MarR_2; pfam12802 1179773008251 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773008252 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1179773008253 Walker A motif; other site 1179773008254 ATP binding site [chemical binding]; other site 1179773008255 Walker B motif; other site 1179773008256 arginine finger; other site 1179773008257 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1179773008258 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773008259 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1179773008260 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1179773008261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773008262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773008263 active site 1179773008264 ATP binding site [chemical binding]; other site 1179773008265 substrate binding site [chemical binding]; other site 1179773008266 activation loop (A-loop); other site 1179773008267 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773008268 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773008269 Interdomain contacts; other site 1179773008270 Cytokine receptor motif; other site 1179773008271 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1179773008272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773008273 acyl-activating enzyme (AAE) consensus motif; other site 1179773008274 AMP binding site [chemical binding]; other site 1179773008275 active site 1179773008276 CoA binding site [chemical binding]; other site 1179773008277 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773008278 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773008279 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773008280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008281 putative substrate translocation pore; other site 1179773008282 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1179773008283 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1179773008284 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1179773008285 substrate binding site [chemical binding]; other site 1179773008286 THF binding site; other site 1179773008287 zinc-binding site [ion binding]; other site 1179773008288 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1179773008289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008291 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1179773008292 B12 binding site [chemical binding]; other site 1179773008293 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1179773008294 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773008295 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1179773008296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1179773008297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773008298 P-loop; other site 1179773008299 Magnesium ion binding site [ion binding]; other site 1179773008300 TIR domain; Region: TIR_2; cl17458 1179773008301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008302 TPR motif; other site 1179773008303 binding surface 1179773008304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1179773008305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773008306 ATP binding site [chemical binding]; other site 1179773008307 Mg2+ binding site [ion binding]; other site 1179773008308 G-X-G motif; other site 1179773008309 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1179773008310 ATP binding site [chemical binding]; other site 1179773008311 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773008312 protein-splicing catalytic site; other site 1179773008313 thioester formation/cholesterol transfer; other site 1179773008314 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1179773008315 protein-splicing catalytic site; other site 1179773008316 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1179773008317 active site 1179773008318 metal binding site [ion binding]; metal-binding site 1179773008319 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1179773008320 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1179773008321 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1179773008322 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773008323 protein-splicing catalytic site; other site 1179773008324 thioester formation/cholesterol transfer; other site 1179773008325 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1179773008326 active site 1179773008327 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1179773008328 protein-splicing catalytic site; other site 1179773008329 thioester formation/cholesterol transfer; other site 1179773008330 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1179773008331 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1179773008332 primary dimer interface [polypeptide binding]; other site 1179773008333 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1179773008334 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1179773008335 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 1179773008336 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773008337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773008338 intersubunit interface [polypeptide binding]; other site 1179773008339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1179773008340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1179773008341 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773008342 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773008343 Walker A/P-loop; other site 1179773008344 ATP binding site [chemical binding]; other site 1179773008345 Q-loop/lid; other site 1179773008346 ABC transporter signature motif; other site 1179773008347 Walker B; other site 1179773008348 D-loop; other site 1179773008349 H-loop/switch region; other site 1179773008350 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1179773008351 YcaO-like family; Region: YcaO; pfam02624 1179773008352 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1179773008353 putative FMN binding site [chemical binding]; other site 1179773008354 NADPH bind site [chemical binding]; other site 1179773008355 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1179773008356 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773008357 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1179773008358 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773008359 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1179773008360 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773008361 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1179773008362 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773008363 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1179773008364 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773008365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008366 putative substrate translocation pore; other site 1179773008367 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773008368 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1179773008369 DNA binding residues [nucleotide binding] 1179773008370 putative dimer interface [polypeptide binding]; other site 1179773008371 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1179773008372 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1179773008373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1179773008374 Transposase; Region: HTH_Tnp_1; pfam01527 1179773008375 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1179773008376 Winged helix-turn helix; Region: HTH_33; pfam13592 1179773008377 putative transposase OrfB; Reviewed; Region: PHA02517 1179773008378 HTH-like domain; Region: HTH_21; pfam13276 1179773008379 Integrase core domain; Region: rve; pfam00665 1179773008380 Integrase core domain; Region: rve_3; cl15866 1179773008381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773008382 Interdomain contacts; other site 1179773008383 Putative amidase domain; Region: Amidase_6; pfam12671 1179773008384 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773008385 Transposase domain (DUF772); Region: DUF772; pfam05598 1179773008386 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773008387 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1179773008388 Integrase core domain; Region: rve; pfam00665 1179773008389 Integrase core domain; Region: rve_2; pfam13333 1179773008390 Transposase; Region: HTH_Tnp_1; pfam01527 1179773008391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1179773008392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773008393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773008394 DNA binding residues [nucleotide binding] 1179773008395 dimerization interface [polypeptide binding]; other site 1179773008396 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1179773008397 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1179773008398 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1179773008399 ABC1 family; Region: ABC1; cl17513 1179773008400 acyl carrier protein; Provisional; Region: acpP; PRK00982 1179773008401 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773008402 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1179773008403 dimer interface [polypeptide binding]; other site 1179773008404 active site 1179773008405 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773008406 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1179773008407 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1179773008408 LytB protein; Region: LYTB; cl00507 1179773008409 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773008410 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773008411 active site 1179773008412 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773008413 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773008414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008415 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1179773008416 Enoylreductase; Region: PKS_ER; smart00829 1179773008417 NAD(P) binding site [chemical binding]; other site 1179773008418 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1179773008419 KR domain; Region: KR; pfam08659 1179773008420 putative NADP binding site [chemical binding]; other site 1179773008421 active site 1179773008422 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773008423 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773008424 hypothetical protein; Provisional; Region: PRK06184 1179773008425 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773008426 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773008427 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1179773008428 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1179773008429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773008430 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773008431 Cytochrome P450; Region: p450; cl12078 1179773008432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773008433 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773008434 substrate binding pocket [chemical binding]; other site 1179773008435 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1179773008436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773008437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773008438 DNA binding residues [nucleotide binding] 1179773008439 dimerization interface [polypeptide binding]; other site 1179773008440 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1179773008441 FMN binding site [chemical binding]; other site 1179773008442 substrate binding site [chemical binding]; other site 1179773008443 putative catalytic residue [active] 1179773008444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773008445 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 1179773008446 active site 1179773008447 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773008448 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773008449 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1179773008450 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773008451 putative NADP binding site [chemical binding]; other site 1179773008452 active site 1179773008453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1179773008454 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1179773008455 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1179773008456 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773008457 S-formylglutathione hydrolase; Region: PLN02442 1179773008458 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1179773008459 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773008460 active site 1179773008461 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773008462 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773008463 active site 1179773008464 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773008465 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773008466 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773008467 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773008468 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1179773008469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008470 Enoylreductase; Region: PKS_ER; smart00829 1179773008471 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1179773008472 NAD(P) binding site [chemical binding]; other site 1179773008473 KR domain; Region: KR; pfam08659 1179773008474 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1179773008475 putative NADP binding site [chemical binding]; other site 1179773008476 active site 1179773008477 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773008478 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773008479 active site 1179773008480 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 1179773008481 acyl carrier protein; Provisional; Region: acpP; PRK00982 1179773008482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008484 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1179773008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008486 S-adenosylmethionine binding site [chemical binding]; other site 1179773008487 PA-IL-like protein; Region: PA-IL; pfam07828 1179773008488 cyclase homology domain; Region: CHD; cd07302 1179773008489 metal binding site [ion binding]; metal-binding site 1179773008490 AAA domain; Region: AAA_22; pfam13401 1179773008491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008493 TPR motif; other site 1179773008494 binding surface 1179773008495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008496 Domain of unknown function (DUF955); Region: DUF955; cl01076 1179773008497 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1179773008498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008499 S-adenosylmethionine binding site [chemical binding]; other site 1179773008500 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773008501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773008502 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773008503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1179773008504 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1179773008505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1179773008506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1179773008507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1179773008508 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773008509 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1179773008510 DDE superfamily endonuclease; Region: DDE_4; cl17710 1179773008511 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1179773008512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773008513 Coenzyme A binding pocket [chemical binding]; other site 1179773008514 RibD C-terminal domain; Region: RibD_C; cl17279 1179773008515 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1179773008516 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1179773008517 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1179773008518 Predicted flavoprotein [General function prediction only]; Region: COG0431 1179773008519 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773008520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773008521 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773008522 Walker A/P-loop; other site 1179773008523 ATP binding site [chemical binding]; other site 1179773008524 Q-loop/lid; other site 1179773008525 ABC transporter signature motif; other site 1179773008526 Walker B; other site 1179773008527 D-loop; other site 1179773008528 H-loop/switch region; other site 1179773008529 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773008530 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773008531 AAA ATPase domain; Region: AAA_16; pfam13191 1179773008532 Predicted ATPase [General function prediction only]; Region: COG3899 1179773008533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008535 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1179773008536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008537 NAD(P) binding site [chemical binding]; other site 1179773008538 active site 1179773008539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773008540 PAS domain; Region: PAS_9; pfam13426 1179773008541 putative active site [active] 1179773008542 heme pocket [chemical binding]; other site 1179773008543 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773008544 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773008545 metal binding site [ion binding]; metal-binding site 1179773008546 active site 1179773008547 I-site; other site 1179773008548 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773008549 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773008550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008551 S-adenosylmethionine binding site [chemical binding]; other site 1179773008552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773008553 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1179773008554 active site triad [active] 1179773008555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773008556 dimerization interface [polypeptide binding]; other site 1179773008557 putative DNA binding site [nucleotide binding]; other site 1179773008558 putative Zn2+ binding site [ion binding]; other site 1179773008559 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1179773008560 polymerase nucleotide-binding site; other site 1179773008561 DNA-binding residues [nucleotide binding]; DNA binding site 1179773008562 nucleotide binding site [chemical binding]; other site 1179773008563 primase nucleotide-binding site [nucleotide binding]; other site 1179773008564 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773008565 DNA binding site [nucleotide binding] 1179773008566 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773008567 NB-ARC domain; Region: NB-ARC; pfam00931 1179773008568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008570 TPR motif; other site 1179773008571 binding surface 1179773008572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008574 TPR motif; other site 1179773008575 binding surface 1179773008576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008577 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773008578 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1179773008579 PA/protease or protease-like domain interface [polypeptide binding]; other site 1179773008580 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1179773008581 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773008582 active site 1179773008583 metal binding site [ion binding]; metal-binding site 1179773008584 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773008585 Cytochrome P450; Region: p450; cl12078 1179773008586 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1179773008587 active site 1179773008588 catalytic triad [active] 1179773008589 oxyanion hole [active] 1179773008590 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1179773008591 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1179773008592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773008593 classical (c) SDRs; Region: SDR_c; cd05233 1179773008594 NAD(P) binding site [chemical binding]; other site 1179773008595 active site 1179773008596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008597 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1179773008598 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1179773008599 NAD binding site [chemical binding]; other site 1179773008600 catalytic residues [active] 1179773008601 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1179773008602 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1179773008603 dimer interface [polypeptide binding]; other site 1179773008604 active site 1179773008605 catalytic residue [active] 1179773008606 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1179773008607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773008608 DNA-binding site [nucleotide binding]; DNA binding site 1179773008609 FCD domain; Region: FCD; pfam07729 1179773008610 hypothetical protein; Provisional; Region: PRK12764 1179773008611 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773008612 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1179773008613 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1179773008614 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1179773008615 putative active site [active] 1179773008616 putative metal binding site [ion binding]; other site 1179773008617 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1179773008618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773008619 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773008620 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773008621 NAD(P) binding site [chemical binding]; other site 1179773008622 catalytic residues [active] 1179773008623 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773008624 RHS Repeat; Region: RHS_repeat; pfam05593 1179773008625 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773008626 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1179773008627 active site 1179773008628 DNA binding site [nucleotide binding] 1179773008629 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1179773008630 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1179773008631 DNA binding site [nucleotide binding] 1179773008632 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1179773008633 nucleotide binding site [chemical binding]; other site 1179773008634 Cupin domain; Region: Cupin_2; cl17218 1179773008635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008636 S-adenosylmethionine binding site [chemical binding]; other site 1179773008637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773008638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773008639 DNA binding residues [nucleotide binding] 1179773008640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773008641 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773008642 MG2 domain; Region: A2M_N; pfam01835 1179773008643 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773008644 classical (c) SDRs; Region: SDR_c; cd05233 1179773008645 NAD(P) binding site [chemical binding]; other site 1179773008646 active site 1179773008647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008648 S-adenosylmethionine binding site [chemical binding]; other site 1179773008649 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1179773008650 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773008651 catalytic Zn binding site [ion binding]; other site 1179773008652 structural Zn binding site [ion binding]; other site 1179773008653 tetramer interface [polypeptide binding]; other site 1179773008654 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1179773008655 TM-ABC transporter signature motif; other site 1179773008656 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1179773008657 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 1179773008658 putative ligand binding site [chemical binding]; other site 1179773008659 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1179773008660 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1179773008661 TM-ABC transporter signature motif; other site 1179773008662 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1179773008663 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1179773008664 Walker A/P-loop; other site 1179773008665 ATP binding site [chemical binding]; other site 1179773008666 Q-loop/lid; other site 1179773008667 ABC transporter signature motif; other site 1179773008668 Walker B; other site 1179773008669 D-loop; other site 1179773008670 H-loop/switch region; other site 1179773008671 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1179773008672 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1179773008673 Walker A/P-loop; other site 1179773008674 ATP binding site [chemical binding]; other site 1179773008675 Q-loop/lid; other site 1179773008676 ABC transporter signature motif; other site 1179773008677 Walker B; other site 1179773008678 D-loop; other site 1179773008679 H-loop/switch region; other site 1179773008680 tyramine oxidase; Provisional; Region: tynA; PRK11504 1179773008681 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1179773008682 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1179773008683 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1179773008684 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1179773008685 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1179773008686 active site 1179773008687 Zn binding site [ion binding]; other site 1179773008688 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1179773008689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773008690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773008691 salt bridge; other site 1179773008692 non-specific DNA binding site [nucleotide binding]; other site 1179773008693 sequence-specific DNA binding site [nucleotide binding]; other site 1179773008694 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1179773008695 nudix motif; other site 1179773008696 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1179773008697 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773008698 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1179773008699 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773008700 NAD binding site [chemical binding]; other site 1179773008701 substrate binding site [chemical binding]; other site 1179773008702 putative active site [active] 1179773008703 bile acid transporter; Region: bass; TIGR00841 1179773008704 Sodium Bile acid symporter family; Region: SBF; cl17470 1179773008705 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773008706 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1179773008707 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773008708 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 1179773008709 putative NAD(P) binding site [chemical binding]; other site 1179773008710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008712 WHG domain; Region: WHG; pfam13305 1179773008713 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1179773008714 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773008715 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773008716 MarR family; Region: MarR_2; pfam12802 1179773008717 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1179773008718 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1179773008719 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773008720 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773008721 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1179773008722 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773008723 TIGR03086 family protein; Region: TIGR03086 1179773008724 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1179773008725 putative FMN binding site [chemical binding]; other site 1179773008726 NADPH bind site [chemical binding]; other site 1179773008727 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1179773008728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773008729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773008730 DNA binding residues [nucleotide binding] 1179773008731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773008732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773008733 non-specific DNA binding site [nucleotide binding]; other site 1179773008734 salt bridge; other site 1179773008735 sequence-specific DNA binding site [nucleotide binding]; other site 1179773008736 NB-ARC domain; Region: NB-ARC; pfam00931 1179773008737 AAA domain; Region: AAA_14; pfam13173 1179773008738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1179773008739 TPR motif; other site 1179773008740 binding surface 1179773008741 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1179773008742 alanine racemase; Reviewed; Region: alr; PRK00053 1179773008743 active site 1179773008744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773008745 dimer interface [polypeptide binding]; other site 1179773008746 substrate binding site [chemical binding]; other site 1179773008747 catalytic residues [active] 1179773008748 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1179773008749 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773008750 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1179773008751 Caspase domain; Region: Peptidase_C14; pfam00656 1179773008752 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773008753 nucleotide binding site [chemical binding]; other site 1179773008754 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773008755 SBD interface [polypeptide binding]; other site 1179773008756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008757 putative substrate translocation pore; other site 1179773008758 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1179773008759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773008760 dimer interface [polypeptide binding]; other site 1179773008761 conserved gate region; other site 1179773008762 putative PBP binding loops; other site 1179773008763 ABC-ATPase subunit interface; other site 1179773008764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773008765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773008766 putative PBP binding loops; other site 1179773008767 dimer interface [polypeptide binding]; other site 1179773008768 ABC-ATPase subunit interface; other site 1179773008769 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773008770 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1179773008771 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773008772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773008773 Walker A/P-loop; other site 1179773008774 ATP binding site [chemical binding]; other site 1179773008775 Q-loop/lid; other site 1179773008776 ABC transporter signature motif; other site 1179773008777 Walker B; other site 1179773008778 D-loop; other site 1179773008779 H-loop/switch region; other site 1179773008780 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1179773008781 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773008782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773008783 Walker A/P-loop; other site 1179773008784 ATP binding site [chemical binding]; other site 1179773008785 Q-loop/lid; other site 1179773008786 ABC transporter signature motif; other site 1179773008787 Walker B; other site 1179773008788 D-loop; other site 1179773008789 H-loop/switch region; other site 1179773008790 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773008791 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1179773008792 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773008793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773008794 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773008795 Predicted acyl esterases [General function prediction only]; Region: COG2936 1179773008796 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1179773008797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773008798 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773008799 active site 1179773008800 catalytic tetrad [active] 1179773008801 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1179773008802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773008803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773008804 active site 1179773008805 phosphorylation site [posttranslational modification] 1179773008806 intermolecular recognition site; other site 1179773008807 dimerization interface [polypeptide binding]; other site 1179773008808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773008809 DNA binding site [nucleotide binding] 1179773008810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773008811 dimerization interface [polypeptide binding]; other site 1179773008812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773008813 dimer interface [polypeptide binding]; other site 1179773008814 phosphorylation site [posttranslational modification] 1179773008815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773008816 ATP binding site [chemical binding]; other site 1179773008817 Mg2+ binding site [ion binding]; other site 1179773008818 G-X-G motif; other site 1179773008819 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1179773008820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773008821 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1179773008822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773008823 Walker A/P-loop; other site 1179773008824 ATP binding site [chemical binding]; other site 1179773008825 Q-loop/lid; other site 1179773008826 ABC transporter signature motif; other site 1179773008827 Walker B; other site 1179773008828 D-loop; other site 1179773008829 H-loop/switch region; other site 1179773008830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773008831 Walker A/P-loop; other site 1179773008832 ATP binding site [chemical binding]; other site 1179773008833 ABC transporter; Region: ABC_tran; pfam00005 1179773008834 Q-loop/lid; other site 1179773008835 ABC transporter signature motif; other site 1179773008836 Walker B; other site 1179773008837 D-loop; other site 1179773008838 H-loop/switch region; other site 1179773008839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773008840 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773008841 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1179773008842 active site 1179773008843 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1179773008844 active site 1179773008845 catalytic triad [active] 1179773008846 dimer interface [polypeptide binding]; other site 1179773008847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008849 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1179773008850 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1179773008851 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1179773008852 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773008853 Putative cyclase; Region: Cyclase; pfam04199 1179773008854 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773008855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773008856 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1179773008857 putative substrate binding pocket [chemical binding]; other site 1179773008858 putative dimerization interface [polypeptide binding]; other site 1179773008859 Domain of unknown function (DUF385); Region: DUF385; cl04387 1179773008860 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1179773008861 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1179773008862 active site 1179773008863 dimer interface [polypeptide binding]; other site 1179773008864 non-prolyl cis peptide bond; other site 1179773008865 insertion regions; other site 1179773008866 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1179773008867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773008868 active site 1179773008869 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1179773008870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773008871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773008872 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773008873 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1179773008874 active site 1179773008875 SAM binding site [chemical binding]; other site 1179773008876 homodimer interface [polypeptide binding]; other site 1179773008877 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773008878 Cytochrome P450; Region: p450; cl12078 1179773008879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1179773008880 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773008881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773008882 sequence-specific DNA binding site [nucleotide binding]; other site 1179773008883 salt bridge; other site 1179773008884 NB-ARC domain; Region: NB-ARC; pfam00931 1179773008885 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773008887 binding surface 1179773008888 TPR motif; other site 1179773008889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008890 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773008891 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1179773008892 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1179773008893 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773008894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773008895 S-adenosylmethionine binding site [chemical binding]; other site 1179773008896 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773008897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773008898 active site 1179773008899 ATP binding site [chemical binding]; other site 1179773008900 substrate binding site [chemical binding]; other site 1179773008901 activation loop (A-loop); other site 1179773008902 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1179773008903 putative active site [active] 1179773008904 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773008905 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1179773008906 putative NAD(P) binding site [chemical binding]; other site 1179773008907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773008910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773008911 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773008912 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773008913 active site 1179773008914 ATP binding site [chemical binding]; other site 1179773008915 substrate binding site [chemical binding]; other site 1179773008916 activation loop (A-loop); other site 1179773008917 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1179773008918 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773008919 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1179773008920 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1179773008921 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773008922 homotrimer interaction site [polypeptide binding]; other site 1179773008923 putative active site [active] 1179773008924 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1179773008925 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773008926 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773008927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008928 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773008929 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773008930 active site 1179773008931 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773008933 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773008934 NAD(P) binding site [chemical binding]; other site 1179773008935 active site 1179773008936 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1179773008937 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773008938 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773008939 acyl carrier protein; Provisional; Region: PRK07081 1179773008940 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773008941 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1179773008942 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1179773008943 active site 1179773008944 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773008945 active site 1179773008946 FkbH-like domain; Region: FkbH; TIGR01686 1179773008947 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 1179773008948 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1179773008949 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773008950 acyl-activating enzyme (AAE) consensus motif; other site 1179773008951 AMP binding site [chemical binding]; other site 1179773008952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773008953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773008954 putative substrate translocation pore; other site 1179773008955 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773008956 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1179773008957 hypothetical protein; Validated; Region: PRK06840 1179773008958 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1179773008959 dimer interface [polypeptide binding]; other site 1179773008960 active site 1179773008961 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1179773008962 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1179773008963 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773008964 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773008965 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773008966 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773008967 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773008968 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773008969 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773008970 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1179773008971 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1179773008972 conserved cys residue [active] 1179773008973 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773008974 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773008975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773008976 S-adenosylmethionine binding site [chemical binding]; other site 1179773008977 Condensation domain; Region: Condensation; pfam00668 1179773008978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008979 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773008980 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773008981 acyl-activating enzyme (AAE) consensus motif; other site 1179773008982 AMP binding site [chemical binding]; other site 1179773008983 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1179773008984 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773008985 putative NAD(P) binding site [chemical binding]; other site 1179773008986 active site 1179773008987 putative substrate binding site [chemical binding]; other site 1179773008988 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773008989 Condensation domain; Region: Condensation; pfam00668 1179773008990 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773008991 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773008992 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1179773008993 acyl-activating enzyme (AAE) consensus motif; other site 1179773008994 AMP binding site [chemical binding]; other site 1179773008995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773008996 FAD binding domain; Region: FAD_binding_3; pfam01494 1179773008997 hypothetical protein; Provisional; Region: PRK07236 1179773008998 Condensation domain; Region: Condensation; pfam00668 1179773008999 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773009000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009001 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773009002 acyl-activating enzyme (AAE) consensus motif; other site 1179773009003 AMP binding site [chemical binding]; other site 1179773009004 active site 1179773009005 CoA binding site [chemical binding]; other site 1179773009006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773009007 Condensation domain; Region: Condensation; pfam00668 1179773009008 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1179773009009 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773009010 acyl-activating enzyme (AAE) consensus motif; other site 1179773009011 AMP binding site [chemical binding]; other site 1179773009012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773009013 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1179773009014 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1179773009015 MbtH-like protein; Region: MbtH; cl01279 1179773009016 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1179773009017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773009018 putative active site [active] 1179773009019 putative metal binding site [ion binding]; other site 1179773009020 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1179773009021 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1179773009022 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1179773009023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773009024 catalytic residue [active] 1179773009025 MFS/sugar transport protein; Region: MFS_2; pfam13347 1179773009026 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1179773009027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773009028 MarR family; Region: MarR; pfam01047 1179773009029 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1179773009030 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773009031 Protein of unknown function (DUF418); Region: DUF418; cl12135 1179773009032 amino acid transporter; Region: 2A0306; TIGR00909 1179773009033 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1179773009034 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773009035 Trp docking motif [polypeptide binding]; other site 1179773009036 active site 1179773009037 PQQ-like domain; Region: PQQ_2; pfam13360 1179773009038 PQQ-like domain; Region: PQQ_2; pfam13360 1179773009039 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773009040 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009041 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009042 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1179773009043 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009044 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009045 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1179773009046 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009048 active site 1179773009049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773009050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773009051 DNA binding residues [nucleotide binding] 1179773009052 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773009053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009055 RNA polymerase sigma factor; Provisional; Region: PRK12513 1179773009056 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1179773009057 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773009058 conserved cys residue [active] 1179773009059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773009060 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1179773009061 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1179773009062 conserved cys residue [active] 1179773009063 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1179773009064 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773009065 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1179773009066 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773009067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773009068 active site 1179773009069 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773009070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009071 AMP-binding enzyme; Region: AMP-binding; pfam00501 1179773009072 acyl-activating enzyme (AAE) consensus motif; other site 1179773009073 AMP binding site [chemical binding]; other site 1179773009074 active site 1179773009075 CoA binding site [chemical binding]; other site 1179773009076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009078 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773009079 classical (c) SDRs; Region: SDR_c; cd05233 1179773009080 NAD(P) binding site [chemical binding]; other site 1179773009081 active site 1179773009082 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773009083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773009084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773009085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773009086 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1179773009087 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009088 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009089 hypothetical protein; Provisional; Region: PRK07758 1179773009090 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1179773009091 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1179773009092 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1179773009093 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773009094 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009095 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009096 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1179773009097 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773009098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009099 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009100 Amidohydrolase; Region: Amidohydro_4; pfam13147 1179773009101 active site 1179773009102 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773009103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773009104 DNA binding residues [nucleotide binding] 1179773009105 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1179773009106 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009107 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009108 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1179773009109 tetramer interface [polypeptide binding]; other site 1179773009110 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773009111 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773009112 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1179773009113 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1179773009114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773009115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773009116 DNA binding residues [nucleotide binding] 1179773009117 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773009118 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773009119 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773009120 putative sugar binding sites [chemical binding]; other site 1179773009121 Q-X-W motif; other site 1179773009122 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773009123 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1179773009124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009125 S-adenosylmethionine binding site [chemical binding]; other site 1179773009126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009127 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1179773009128 Amidase; Region: Amidase; pfam01425 1179773009129 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773009130 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1179773009131 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1179773009132 TrkA-C domain; Region: TrkA_C; pfam02080 1179773009133 TrkA-C domain; Region: TrkA_C; pfam02080 1179773009134 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1179773009135 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1179773009136 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1179773009137 TrkA-C domain; Region: TrkA_C; pfam02080 1179773009138 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1179773009139 aspartate aminotransferase; Provisional; Region: PRK09275 1179773009140 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1179773009141 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1179773009142 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 1179773009143 P-loop motif; other site 1179773009144 ATP binding site [chemical binding]; other site 1179773009145 Chloramphenicol (Cm) binding site [chemical binding]; other site 1179773009146 catalytic residue [active] 1179773009147 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1179773009148 Part of AAA domain; Region: AAA_19; pfam13245 1179773009149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773009150 active site 1179773009151 ATP binding site [chemical binding]; other site 1179773009152 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773009153 substrate binding site [chemical binding]; other site 1179773009154 activation loop (A-loop); other site 1179773009155 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773009156 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773009157 DNA binding residues [nucleotide binding] 1179773009158 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1179773009159 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1179773009160 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773009161 metal ion-dependent adhesion site (MIDAS); other site 1179773009162 CHAT domain; Region: CHAT; pfam12770 1179773009163 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773009164 DNA binding site [nucleotide binding] 1179773009165 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773009166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773009168 binding surface 1179773009169 TPR motif; other site 1179773009170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009171 CHAT domain; Region: CHAT; cl17868 1179773009172 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1179773009173 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773009174 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1179773009175 active site 1179773009176 catalytic triad [active] 1179773009177 oxyanion hole [active] 1179773009178 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1179773009179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773009180 NAD(P) binding site [chemical binding]; other site 1179773009181 active site 1179773009182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009184 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1179773009185 Domain of unknown function (DUF202); Region: DUF202; cl09954 1179773009186 Domain of unknown function (DUF202); Region: DUF202; cl09954 1179773009187 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1179773009188 active site 1179773009189 catalytic site [active] 1179773009190 substrate binding site [chemical binding]; other site 1179773009191 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1179773009192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009193 putative substrate translocation pore; other site 1179773009194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773009195 RNA binding surface [nucleotide binding]; other site 1179773009196 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773009197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773009198 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1179773009199 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1179773009200 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009201 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009202 AAA domain; Region: AAA_33; pfam13671 1179773009203 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 1179773009204 P-loop motif; other site 1179773009205 ATP binding site [chemical binding]; other site 1179773009206 Chloramphenicol (Cm) binding site [chemical binding]; other site 1179773009207 catalytic residue [active] 1179773009208 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1179773009209 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1179773009210 active site 1179773009211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773009212 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1179773009213 ATP binding site [chemical binding]; other site 1179773009214 putative Mg++ binding site [ion binding]; other site 1179773009215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773009216 nucleotide binding region [chemical binding]; other site 1179773009217 ATP-binding site [chemical binding]; other site 1179773009218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773009219 putative DNA binding site [nucleotide binding]; other site 1179773009220 putative Zn2+ binding site [ion binding]; other site 1179773009221 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1179773009222 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009223 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773009225 Histidine kinase; Region: HisKA_3; pfam07730 1179773009226 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773009227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009229 active site 1179773009230 phosphorylation site [posttranslational modification] 1179773009231 intermolecular recognition site; other site 1179773009232 dimerization interface [polypeptide binding]; other site 1179773009233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009234 DNA binding residues [nucleotide binding] 1179773009235 dimerization interface [polypeptide binding]; other site 1179773009236 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773009237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773009238 Histidine kinase; Region: HisKA_3; pfam07730 1179773009239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773009240 ATP binding site [chemical binding]; other site 1179773009241 Mg2+ binding site [ion binding]; other site 1179773009242 G-X-G motif; other site 1179773009243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009245 active site 1179773009246 phosphorylation site [posttranslational modification] 1179773009247 intermolecular recognition site; other site 1179773009248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009249 DNA binding residues [nucleotide binding] 1179773009250 dimerization interface [polypeptide binding]; other site 1179773009251 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1179773009252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773009253 classical (c) SDRs; Region: SDR_c; cd05233 1179773009254 NAD(P) binding site [chemical binding]; other site 1179773009255 active site 1179773009256 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1179773009257 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773009258 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1179773009259 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773009260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773009261 dimerization interface [polypeptide binding]; other site 1179773009262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773009263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009264 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773009265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773009267 TPR motif; other site 1179773009268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009269 binding surface 1179773009270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009271 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1179773009272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773009273 catalytic residue [active] 1179773009274 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1179773009275 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1179773009276 putative active site [active] 1179773009277 putative dimer interface [polypeptide binding]; other site 1179773009278 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1179773009279 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1179773009280 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1179773009281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009282 active site 1179773009283 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1179773009284 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1179773009285 metal ion-dependent adhesion site (MIDAS); other site 1179773009286 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773009287 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1179773009288 Walker A motif; other site 1179773009289 ATP binding site [chemical binding]; other site 1179773009290 Walker B motif; other site 1179773009291 arginine finger; other site 1179773009292 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1179773009293 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1179773009294 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773009295 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773009296 Predicted ATPase [General function prediction only]; Region: COG3903 1179773009297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009298 hypothetical protein; Provisional; Region: PRK07236 1179773009299 hypothetical protein; Provisional; Region: PRK07588 1179773009300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1179773009301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773009302 dimer interface [polypeptide binding]; other site 1179773009303 conserved gate region; other site 1179773009304 putative PBP binding loops; other site 1179773009305 ABC-ATPase subunit interface; other site 1179773009306 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773009307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773009308 Walker A/P-loop; other site 1179773009309 ATP binding site [chemical binding]; other site 1179773009310 Q-loop/lid; other site 1179773009311 ABC transporter signature motif; other site 1179773009312 Walker B; other site 1179773009313 D-loop; other site 1179773009314 H-loop/switch region; other site 1179773009315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773009316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773009317 substrate binding pocket [chemical binding]; other site 1179773009318 membrane-bound complex binding site; other site 1179773009319 hinge residues; other site 1179773009320 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1179773009321 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1179773009322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773009323 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773009324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773009325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1179773009327 active site 1179773009328 phosphorylation site [posttranslational modification] 1179773009329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009330 DNA binding residues [nucleotide binding] 1179773009331 dimerization interface [polypeptide binding]; other site 1179773009332 Histidine kinase; Region: HisKA_3; pfam07730 1179773009333 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773009334 hydrophobic ligand binding site; other site 1179773009335 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1179773009336 putative hydrophobic ligand binding site [chemical binding]; other site 1179773009337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773009338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773009339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773009340 dimerization interface [polypeptide binding]; other site 1179773009341 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1179773009342 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1179773009343 PYR/PP interface [polypeptide binding]; other site 1179773009344 dimer interface [polypeptide binding]; other site 1179773009345 TPP binding site [chemical binding]; other site 1179773009346 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773009347 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1179773009348 TPP-binding site [chemical binding]; other site 1179773009349 dimer interface [polypeptide binding]; other site 1179773009350 benzoate transport; Region: 2A0115; TIGR00895 1179773009351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009352 putative substrate translocation pore; other site 1179773009353 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1179773009354 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773009355 active site 1179773009356 metal binding site [ion binding]; metal-binding site 1179773009357 AAA domain; Region: AAA_33; pfam13671 1179773009358 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773009359 active site 1179773009360 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1179773009361 Zn binding site [ion binding]; other site 1179773009362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009363 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773009364 acyl-activating enzyme (AAE) consensus motif; other site 1179773009365 AMP binding site [chemical binding]; other site 1179773009366 active site 1179773009367 CoA binding site [chemical binding]; other site 1179773009368 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1179773009369 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773009370 putative trimer interface [polypeptide binding]; other site 1179773009371 putative CoA binding site [chemical binding]; other site 1179773009372 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773009373 putative trimer interface [polypeptide binding]; other site 1179773009374 putative CoA binding site [chemical binding]; other site 1179773009375 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1179773009376 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773009377 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773009378 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773009379 structural tetrad; other site 1179773009380 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773009381 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773009382 structural tetrad; other site 1179773009383 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773009384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009386 DNA binding residues [nucleotide binding] 1179773009387 dimerization interface [polypeptide binding]; other site 1179773009388 Helix-turn-helix domain; Region: HTH_36; pfam13730 1179773009389 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1179773009390 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1179773009391 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1179773009392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773009393 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773009394 dimerization interface [polypeptide binding]; other site 1179773009395 substrate binding pocket [chemical binding]; other site 1179773009396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773009398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773009399 dimer interface [polypeptide binding]; other site 1179773009400 conserved gate region; other site 1179773009401 putative PBP binding loops; other site 1179773009402 ABC-ATPase subunit interface; other site 1179773009403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773009404 dimer interface [polypeptide binding]; other site 1179773009405 conserved gate region; other site 1179773009406 putative PBP binding loops; other site 1179773009407 ABC-ATPase subunit interface; other site 1179773009408 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1179773009409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773009410 active site 1179773009411 metal binding site [ion binding]; metal-binding site 1179773009412 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773009413 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1179773009414 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1179773009415 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1179773009416 Walker A/P-loop; other site 1179773009417 ATP binding site [chemical binding]; other site 1179773009418 Q-loop/lid; other site 1179773009419 ABC transporter signature motif; other site 1179773009420 Walker B; other site 1179773009421 D-loop; other site 1179773009422 H-loop/switch region; other site 1179773009423 TOBE domain; Region: TOBE_2; pfam08402 1179773009424 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1179773009425 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1179773009426 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1179773009427 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1179773009428 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773009429 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773009430 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1179773009431 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1179773009432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773009433 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773009434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773009435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009436 S-adenosylmethionine binding site [chemical binding]; other site 1179773009437 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773009438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009439 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773009440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009441 acyl-activating enzyme (AAE) consensus motif; other site 1179773009442 AMP binding site [chemical binding]; other site 1179773009443 active site 1179773009444 CoA binding site [chemical binding]; other site 1179773009445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773009446 PQQ-like domain; Region: PQQ_2; pfam13360 1179773009447 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1179773009448 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1179773009449 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1179773009450 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1179773009451 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1179773009452 homodimer interface [polypeptide binding]; other site 1179773009453 substrate-cofactor binding pocket; other site 1179773009454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773009455 catalytic residue [active] 1179773009456 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1179773009457 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773009458 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1179773009459 nucleophilic elbow; other site 1179773009460 catalytic triad; other site 1179773009461 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773009462 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1179773009463 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773009464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773009465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773009466 dimer interface [polypeptide binding]; other site 1179773009467 conserved gate region; other site 1179773009468 ABC-ATPase subunit interface; other site 1179773009469 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1179773009470 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1179773009471 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773009472 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773009473 Walker A/P-loop; other site 1179773009474 ATP binding site [chemical binding]; other site 1179773009475 Q-loop/lid; other site 1179773009476 ABC transporter signature motif; other site 1179773009477 Walker B; other site 1179773009478 D-loop; other site 1179773009479 H-loop/switch region; other site 1179773009480 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773009481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773009482 Walker A/P-loop; other site 1179773009483 ATP binding site [chemical binding]; other site 1179773009484 Q-loop/lid; other site 1179773009485 ABC transporter signature motif; other site 1179773009486 Walker B; other site 1179773009487 D-loop; other site 1179773009488 H-loop/switch region; other site 1179773009489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773009490 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773009491 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773009492 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1179773009493 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1179773009494 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1179773009495 oligomer interface [polypeptide binding]; other site 1179773009496 metal binding site [ion binding]; metal-binding site 1179773009497 metal binding site [ion binding]; metal-binding site 1179773009498 putative Cl binding site [ion binding]; other site 1179773009499 aspartate ring; other site 1179773009500 basic sphincter; other site 1179773009501 hydrophobic gate; other site 1179773009502 periplasmic entrance; other site 1179773009503 hypothetical protein; Provisional; Region: PRK07877 1179773009504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773009505 GAF domain; Region: GAF; pfam01590 1179773009506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773009507 GAF domain; Region: GAF_3; pfam13492 1179773009508 Histidine kinase; Region: HisKA_3; pfam07730 1179773009509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773009510 ATP binding site [chemical binding]; other site 1179773009511 Mg2+ binding site [ion binding]; other site 1179773009512 G-X-G motif; other site 1179773009513 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773009514 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1179773009515 catalytic triad [active] 1179773009516 conserved cis-peptide bond; other site 1179773009517 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1179773009518 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1179773009519 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773009520 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1179773009521 Glyco_18 domain; Region: Glyco_18; smart00636 1179773009522 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773009523 active site 1179773009524 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1179773009525 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1179773009526 NAD(P) binding site [chemical binding]; other site 1179773009527 substrate binding site [chemical binding]; other site 1179773009528 dimer interface [polypeptide binding]; other site 1179773009529 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773009530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773009531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773009532 dimerization interface [polypeptide binding]; other site 1179773009533 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1179773009534 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773009535 DNA binding residues [nucleotide binding] 1179773009536 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773009537 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773009538 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1179773009539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773009540 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1179773009541 hydrophobic ligand binding site; other site 1179773009542 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1179773009543 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1179773009544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009546 active site 1179773009547 phosphorylation site [posttranslational modification] 1179773009548 intermolecular recognition site; other site 1179773009549 dimerization interface [polypeptide binding]; other site 1179773009550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009551 DNA binding residues [nucleotide binding] 1179773009552 dimerization interface [polypeptide binding]; other site 1179773009553 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773009554 Ligand Binding Site [chemical binding]; other site 1179773009555 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773009556 Ligand Binding Site [chemical binding]; other site 1179773009557 putative phosphoketolase; Provisional; Region: PRK05261 1179773009558 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1179773009559 TPP-binding site; other site 1179773009560 XFP C-terminal domain; Region: XFP_C; pfam09363 1179773009561 Acetokinase family; Region: Acetate_kinase; cl17229 1179773009562 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1179773009563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773009564 Coenzyme A binding pocket [chemical binding]; other site 1179773009565 SnoaL-like domain; Region: SnoaL_4; pfam13577 1179773009566 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1179773009567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773009571 putative substrate translocation pore; other site 1179773009572 Cellulose binding domain; Region: CBM_2; pfam00553 1179773009573 Right handed beta helix region; Region: Beta_helix; pfam13229 1179773009574 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1179773009575 EamA-like transporter family; Region: EamA; pfam00892 1179773009576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773009577 MarR family; Region: MarR_2; cl17246 1179773009578 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773009579 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773009580 active site 1179773009581 ATP binding site [chemical binding]; other site 1179773009582 substrate binding site [chemical binding]; other site 1179773009583 activation loop (A-loop); other site 1179773009584 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773009585 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773009586 structural tetrad; other site 1179773009587 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773009588 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773009589 structural tetrad; other site 1179773009590 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773009591 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773009592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773009593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1179773009594 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773009595 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773009596 phosphate binding site [ion binding]; other site 1179773009597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773009598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773009599 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773009600 putative dimerization interface [polypeptide binding]; other site 1179773009601 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1179773009602 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1179773009603 TM-ABC transporter signature motif; other site 1179773009604 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 1179773009605 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773009606 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773009607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773009608 NAD(P) binding site [chemical binding]; other site 1179773009609 active site 1179773009610 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773009611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773009612 dimerization interface [polypeptide binding]; other site 1179773009613 putative DNA binding site [nucleotide binding]; other site 1179773009614 putative Zn2+ binding site [ion binding]; other site 1179773009615 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1179773009616 NAD-dependent deacetylase; Provisional; Region: PRK00481 1179773009617 NAD+ binding site [chemical binding]; other site 1179773009618 substrate binding site [chemical binding]; other site 1179773009619 Zn binding site [ion binding]; other site 1179773009620 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773009621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773009622 active site 1179773009623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773009624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009625 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009626 acyl-activating enzyme (AAE) consensus motif; other site 1179773009627 active site 1179773009628 AMP binding site [chemical binding]; other site 1179773009629 CoA binding site [chemical binding]; other site 1179773009630 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009631 Cytochrome P450; Region: p450; cl12078 1179773009632 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1179773009633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1179773009634 active site 1179773009635 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1179773009636 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1179773009637 dimer interface [polypeptide binding]; other site 1179773009638 active site 1179773009639 CoA binding pocket [chemical binding]; other site 1179773009640 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009641 Cytochrome P450; Region: p450; cl12078 1179773009642 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1179773009643 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1179773009644 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1179773009645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009647 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009648 Cytochrome P450; Region: p450; cl12078 1179773009649 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009650 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009651 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009652 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009653 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009654 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009655 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009656 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009657 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009658 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773009659 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1179773009660 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1179773009661 putative active site [active] 1179773009662 catalytic triad [active] 1179773009663 putative dimer interface [polypeptide binding]; other site 1179773009664 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773009665 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773009666 catalytic triad [active] 1179773009667 conserved cis-peptide bond; other site 1179773009668 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773009669 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1179773009670 substrate binding pocket [chemical binding]; other site 1179773009671 catalytic triad [active] 1179773009672 AAA ATPase domain; Region: AAA_16; pfam13191 1179773009673 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1179773009674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773009675 ABC transporter signature motif; other site 1179773009676 Walker B; other site 1179773009677 D-loop; other site 1179773009678 H-loop/switch region; other site 1179773009679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773009680 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 1179773009681 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773009682 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773009683 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773009684 calcium binding site 2 [ion binding]; other site 1179773009685 active site 1179773009686 catalytic triad [active] 1179773009687 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773009688 calcium binding site 1 [ion binding]; other site 1179773009689 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1179773009690 Zn binding site [ion binding]; other site 1179773009691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773009692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773009693 non-specific DNA binding site [nucleotide binding]; other site 1179773009694 salt bridge; other site 1179773009695 sequence-specific DNA binding site [nucleotide binding]; other site 1179773009696 AAA domain; Region: AAA_22; pfam13401 1179773009697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773009698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773009699 non-specific DNA binding site [nucleotide binding]; other site 1179773009700 salt bridge; other site 1179773009701 sequence-specific DNA binding site [nucleotide binding]; other site 1179773009702 AAA ATPase domain; Region: AAA_16; pfam13191 1179773009703 NACHT domain; Region: NACHT; pfam05729 1179773009704 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009705 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009706 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009707 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009708 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009709 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1179773009710 putative active site [active] 1179773009711 Carboxylesterase family; Region: COesterase; pfam00135 1179773009712 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773009713 substrate binding pocket [chemical binding]; other site 1179773009714 catalytic triad [active] 1179773009715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773009716 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773009717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009718 S-adenosylmethionine binding site [chemical binding]; other site 1179773009719 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773009720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773009721 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773009722 active site 1179773009723 metal binding site [ion binding]; metal-binding site 1179773009724 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773009725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009726 S-adenosylmethionine binding site [chemical binding]; other site 1179773009727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009729 WHG domain; Region: WHG; pfam13305 1179773009730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773009731 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773009732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773009733 Walker A/P-loop; other site 1179773009734 ATP binding site [chemical binding]; other site 1179773009735 Q-loop/lid; other site 1179773009736 ABC transporter signature motif; other site 1179773009737 Walker B; other site 1179773009738 D-loop; other site 1179773009739 H-loop/switch region; other site 1179773009740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773009741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773009742 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773009743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773009744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773009745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773009746 Walker A/P-loop; other site 1179773009747 Walker A/P-loop; other site 1179773009748 ATP binding site [chemical binding]; other site 1179773009749 ATP binding site [chemical binding]; other site 1179773009750 Q-loop/lid; other site 1179773009751 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773009752 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1179773009753 AAA ATPase domain; Region: AAA_16; pfam13191 1179773009754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009756 dimerization interface [polypeptide binding]; other site 1179773009757 DNA binding residues [nucleotide binding] 1179773009758 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773009759 cleavage site 1179773009760 active site 1179773009761 substrate binding sites [chemical binding]; other site 1179773009762 chlorophyllase; Region: PLN00021 1179773009763 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1179773009764 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1179773009765 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1179773009766 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773009767 ATP binding site [chemical binding]; other site 1179773009768 Mg2+ binding site [ion binding]; other site 1179773009769 G-X-G motif; other site 1179773009770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009772 active site 1179773009773 phosphorylation site [posttranslational modification] 1179773009774 intermolecular recognition site; other site 1179773009775 dimerization interface [polypeptide binding]; other site 1179773009776 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773009777 Family description; Region: VCBS; pfam13517 1179773009778 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1179773009779 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773009780 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773009781 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1179773009782 FtsX-like permease family; Region: FtsX; pfam02687 1179773009783 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773009784 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773009785 Walker A/P-loop; other site 1179773009786 ATP binding site [chemical binding]; other site 1179773009787 Q-loop/lid; other site 1179773009788 ABC transporter signature motif; other site 1179773009789 Walker B; other site 1179773009790 D-loop; other site 1179773009791 H-loop/switch region; other site 1179773009792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773009793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009794 active site 1179773009795 phosphorylation site [posttranslational modification] 1179773009796 intermolecular recognition site; other site 1179773009797 dimerization interface [polypeptide binding]; other site 1179773009798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773009799 DNA binding site [nucleotide binding] 1179773009800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773009801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773009802 dimerization interface [polypeptide binding]; other site 1179773009803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773009804 dimer interface [polypeptide binding]; other site 1179773009805 phosphorylation site [posttranslational modification] 1179773009806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773009807 ATP binding site [chemical binding]; other site 1179773009808 G-X-G motif; other site 1179773009809 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1179773009810 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773009811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773009812 active site 1179773009813 phosphorylation site [posttranslational modification] 1179773009814 intermolecular recognition site; other site 1179773009815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773009816 DNA binding residues [nucleotide binding] 1179773009817 dimerization interface [polypeptide binding]; other site 1179773009818 Histidine kinase; Region: HisKA_3; pfam07730 1179773009819 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773009820 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773009821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773009822 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009823 Cytochrome P450; Region: p450; cl12078 1179773009824 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773009825 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773009826 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1179773009827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773009828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773009829 DNA binding residues [nucleotide binding] 1179773009830 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773009831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009833 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1179773009834 Condensation domain; Region: Condensation; pfam00668 1179773009835 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773009836 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773009837 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773009838 acyl-activating enzyme (AAE) consensus motif; other site 1179773009839 AMP binding site [chemical binding]; other site 1179773009840 active site 1179773009841 CoA binding site [chemical binding]; other site 1179773009842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773009843 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1179773009844 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773009845 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1179773009846 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1179773009847 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1179773009848 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1179773009849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773009850 S-adenosylmethionine binding site [chemical binding]; other site 1179773009851 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773009852 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773009853 active site 1179773009854 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773009855 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773009856 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1179773009857 KR domain; Region: KR; pfam08659 1179773009858 NADP binding site [chemical binding]; other site 1179773009859 active site 1179773009860 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773009861 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009862 Cytochrome P450; Region: p450; cl12078 1179773009863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773009864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773009865 active site 1179773009866 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009867 Cytochrome P450; Region: p450; cl12078 1179773009868 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1179773009869 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1179773009870 E3 interaction surface; other site 1179773009871 lipoyl attachment site [posttranslational modification]; other site 1179773009872 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1179773009873 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1179773009874 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1179773009875 alpha subunit interface [polypeptide binding]; other site 1179773009876 TPP binding site [chemical binding]; other site 1179773009877 heterodimer interface [polypeptide binding]; other site 1179773009878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773009879 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1179773009880 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1179773009881 tetramer interface [polypeptide binding]; other site 1179773009882 TPP-binding site [chemical binding]; other site 1179773009883 heterodimer interface [polypeptide binding]; other site 1179773009884 phosphorylation loop region [posttranslational modification] 1179773009885 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1179773009886 Chorismate mutase type II; Region: CM_2; cl00693 1179773009887 SnoaL-like domain; Region: SnoaL_3; pfam13474 1179773009888 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1179773009889 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1179773009890 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1179773009891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773009892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773009893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009894 Cytochrome P450; Region: p450; cl12078 1179773009895 Family description; Region: VCBS; pfam13517 1179773009896 Family description; Region: VCBS; pfam13517 1179773009897 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1179773009898 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1179773009899 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1179773009900 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773009901 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1179773009902 active site 1179773009903 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773009904 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1179773009905 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773009906 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773009907 putative NADP binding site [chemical binding]; other site 1179773009908 active site 1179773009909 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773009910 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1179773009911 active site 1179773009912 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773009913 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1179773009914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773009915 NAD(P) binding site [chemical binding]; other site 1179773009916 active site 1179773009917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773009918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773009919 WHG domain; Region: WHG; pfam13305 1179773009920 TIGR03084 family protein; Region: TIGR03084 1179773009921 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773009922 Wyosine base formation; Region: Wyosine_form; pfam08608 1179773009923 Amidase; Region: Amidase; pfam01425 1179773009924 YCII-related domain; Region: YCII; cl00999 1179773009925 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1179773009926 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1179773009927 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1179773009928 transcription termination factor Rho; Provisional; Region: PRK12608 1179773009929 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1179773009930 RNA binding site [nucleotide binding]; other site 1179773009931 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1179773009932 Walker A motif; other site 1179773009933 ATP binding site [chemical binding]; other site 1179773009934 Walker B motif; other site 1179773009935 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773009936 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1179773009937 RHS Repeat; Region: RHS_repeat; pfam05593 1179773009938 RHS Repeat; Region: RHS_repeat; pfam05593 1179773009939 RHS Repeat; Region: RHS_repeat; pfam05593 1179773009940 RHS Repeat; Region: RHS_repeat; pfam05593 1179773009941 RHS Repeat; Region: RHS_repeat; pfam05593 1179773009942 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773009943 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1179773009944 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1179773009945 DYW family of nucleic acid deaminases; Region: DYW_deaminase; pfam14432 1179773009946 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773009947 Predicted membrane protein [Function unknown]; Region: COG4425 1179773009948 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1179773009949 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1179773009950 Scramblase; Region: Scramblase; pfam03803 1179773009951 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1179773009952 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1179773009953 dimer interface [polypeptide binding]; other site 1179773009954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773009955 catalytic residue [active] 1179773009956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773009957 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773009958 putative substrate translocation pore; other site 1179773009959 argininosuccinate lyase; Provisional; Region: PRK02186 1179773009960 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1179773009961 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1179773009962 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773009963 Cytochrome P450; Region: p450; cl12078 1179773009964 D-glutamate deacylase; Validated; Region: PRK09061 1179773009965 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009966 active site 1179773009967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773009968 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773009969 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773009970 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009971 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009972 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009973 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009974 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009975 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773009976 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773009977 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773009978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773009981 binding surface 1179773009982 TPR motif; other site 1179773009983 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773009984 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773009985 Ca2+ binding site [ion binding]; other site 1179773009986 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773009987 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773009988 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773009989 Ca2+ binding site [ion binding]; other site 1179773009990 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1179773009991 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1179773009992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773009993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773009994 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1179773009995 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773009996 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1179773009997 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1179773009998 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1179773009999 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1179773010000 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773010001 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773010002 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773010003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773010004 carboxyltransferase (CT) interaction site; other site 1179773010005 biotinylation site [posttranslational modification]; other site 1179773010006 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1179773010007 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1179773010008 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1179773010009 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1179773010010 ligand binding site [chemical binding]; other site 1179773010011 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1179773010012 Predicted transcriptional regulators [Transcription]; Region: COG1510 1179773010013 MarR family; Region: MarR_2; pfam12802 1179773010014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773010015 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1179773010016 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773010017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773010018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773010019 DNA binding residues [nucleotide binding] 1179773010020 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1179773010021 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1179773010022 multimer interface [polypeptide binding]; other site 1179773010023 active site 1179773010024 catalytic triad [active] 1179773010025 dimer interface [polypeptide binding]; other site 1179773010026 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1179773010027 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1179773010028 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1179773010029 putative ligand binding site [chemical binding]; other site 1179773010030 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773010031 MarR family; Region: MarR_2; pfam12802 1179773010032 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1179773010033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773010034 Walker A/P-loop; other site 1179773010035 ATP binding site [chemical binding]; other site 1179773010036 Q-loop/lid; other site 1179773010037 ABC transporter signature motif; other site 1179773010038 Walker B; other site 1179773010039 D-loop; other site 1179773010040 H-loop/switch region; other site 1179773010041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1179773010042 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773010043 Walker A/P-loop; other site 1179773010044 ATP binding site [chemical binding]; other site 1179773010045 Q-loop/lid; other site 1179773010046 ABC transporter signature motif; other site 1179773010047 Walker B; other site 1179773010048 D-loop; other site 1179773010049 H-loop/switch region; other site 1179773010050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1179773010051 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1179773010052 peptide binding site [polypeptide binding]; other site 1179773010053 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773010054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773010055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773010056 putative PBP binding loops; other site 1179773010057 dimer interface [polypeptide binding]; other site 1179773010058 ABC-ATPase subunit interface; other site 1179773010059 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773010060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773010061 dimer interface [polypeptide binding]; other site 1179773010062 conserved gate region; other site 1179773010063 putative PBP binding loops; other site 1179773010064 ABC-ATPase subunit interface; other site 1179773010065 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1179773010066 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1179773010067 MOSC domain; Region: MOSC; pfam03473 1179773010068 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773010069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773010071 putative substrate translocation pore; other site 1179773010072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010073 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773010074 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773010075 Rrf2 family protein; Region: rrf2_super; TIGR00738 1179773010076 Transcriptional regulator; Region: Rrf2; pfam02082 1179773010077 Transcriptional regulator; Region: Rrf2; cl17282 1179773010078 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773010079 homotrimer interaction site [polypeptide binding]; other site 1179773010080 putative active site [active] 1179773010081 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773010082 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773010083 catalytic residue [active] 1179773010084 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1179773010085 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1179773010086 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1179773010087 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1179773010088 Cysteine-rich domain; Region: CCG; pfam02754 1179773010089 Cysteine-rich domain; Region: CCG; pfam02754 1179773010090 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773010091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773010092 DNA-binding site [nucleotide binding]; DNA binding site 1179773010093 FCD domain; Region: FCD; pfam07729 1179773010094 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1179773010095 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773010096 substrate binding pocket [chemical binding]; other site 1179773010097 catalytic triad [active] 1179773010098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773010099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010100 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1179773010101 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1179773010102 acyl-activating enzyme (AAE) consensus motif; other site 1179773010103 putative AMP binding site [chemical binding]; other site 1179773010104 putative active site [active] 1179773010105 putative CoA binding site [chemical binding]; other site 1179773010106 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1179773010107 putative catalytic site [active] 1179773010108 putative metal binding site [ion binding]; other site 1179773010109 putative phosphate binding site [ion binding]; other site 1179773010110 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1179773010111 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1179773010112 RNA ligase; Region: RNA_ligase; pfam09414 1179773010113 AAA domain; Region: AAA_33; pfam13671 1179773010114 heat shock protein 90; Provisional; Region: PRK05218 1179773010115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773010116 ATP binding site [chemical binding]; other site 1179773010117 Mg2+ binding site [ion binding]; other site 1179773010118 G-X-G motif; other site 1179773010119 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010121 DNA binding residues [nucleotide binding] 1179773010122 dimerization interface [polypeptide binding]; other site 1179773010123 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1179773010124 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1179773010125 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1179773010126 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773010127 Walker A/P-loop; other site 1179773010128 ATP binding site [chemical binding]; other site 1179773010129 Q-loop/lid; other site 1179773010130 ABC transporter signature motif; other site 1179773010131 Walker B; other site 1179773010132 D-loop; other site 1179773010133 H-loop/switch region; other site 1179773010134 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1179773010135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773010136 membrane-bound complex binding site; other site 1179773010137 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773010138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773010139 dimer interface [polypeptide binding]; other site 1179773010140 conserved gate region; other site 1179773010141 ABC-ATPase subunit interface; other site 1179773010142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773010143 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1179773010144 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1179773010145 catalytic residues [active] 1179773010146 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773010147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773010148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773010149 MarR family; Region: MarR_2; pfam12802 1179773010150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010152 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773010153 cleavage site 1179773010154 active site 1179773010155 substrate binding sites [chemical binding]; other site 1179773010156 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773010157 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1179773010158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773010159 dimerization interface [polypeptide binding]; other site 1179773010160 putative DNA binding site [nucleotide binding]; other site 1179773010161 putative Zn2+ binding site [ion binding]; other site 1179773010162 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773010163 Cytochrome P450; Region: p450; cl12078 1179773010164 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773010165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773010166 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773010167 catalytic site [active] 1179773010168 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1179773010169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1179773010170 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1179773010171 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773010172 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1179773010173 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773010174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773010175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773010176 DNA binding residues [nucleotide binding] 1179773010177 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773010178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773010179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773010180 active site 1179773010181 catalytic tetrad [active] 1179773010182 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773010183 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773010184 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773010185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773010186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010187 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1179773010188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773010189 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773010191 active site 1179773010192 phosphorylation site [posttranslational modification] 1179773010193 intermolecular recognition site; other site 1179773010194 dimerization interface [polypeptide binding]; other site 1179773010195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010196 DNA binding residues [nucleotide binding] 1179773010197 dimerization interface [polypeptide binding]; other site 1179773010198 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1179773010199 active site 1179773010200 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1179773010201 CHAT domain; Region: CHAT; pfam12770 1179773010202 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773010203 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773010204 active site 1179773010205 catalytic residues [active] 1179773010206 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1179773010207 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773010208 putative active site [active] 1179773010209 putative metal binding site [ion binding]; other site 1179773010210 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773010211 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773010212 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1179773010213 active site 1179773010214 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1179773010215 maltose O-acetyltransferase; Provisional; Region: PRK10092 1179773010216 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1179773010217 active site 1179773010218 substrate binding site [chemical binding]; other site 1179773010219 trimer interface [polypeptide binding]; other site 1179773010220 CoA binding site [chemical binding]; other site 1179773010221 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1179773010222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773010223 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773010224 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773010225 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773010226 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 1179773010227 NodB motif; other site 1179773010228 putative active site [active] 1179773010229 putative catalytic site [active] 1179773010230 putative Zn binding site [ion binding]; other site 1179773010231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773010232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010233 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773010234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773010236 PaaX-like protein; Region: PaaX; pfam07848 1179773010237 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1179773010238 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1179773010239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773010240 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1179773010241 acyl-activating enzyme (AAE) consensus motif; other site 1179773010242 AMP binding site [chemical binding]; other site 1179773010243 active site 1179773010244 CoA binding site [chemical binding]; other site 1179773010245 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1179773010246 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1179773010247 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773010248 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1179773010249 Cupin domain; Region: Cupin_2; pfam07883 1179773010250 Cupin domain; Region: Cupin_2; pfam07883 1179773010251 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773010252 active site 2 [active] 1179773010253 active site 1 [active] 1179773010254 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1179773010255 hypothetical protein; Provisional; Region: PRK07236 1179773010256 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773010257 phosphate binding site [ion binding]; other site 1179773010258 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1179773010259 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1179773010260 putative active site [active] 1179773010261 catalytic triad [active] 1179773010262 putative dimer interface [polypeptide binding]; other site 1179773010263 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1179773010264 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1179773010265 metal binding site [ion binding]; metal-binding site 1179773010266 putative dimer interface [polypeptide binding]; other site 1179773010267 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773010268 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1179773010269 DNA binding residues [nucleotide binding] 1179773010270 drug binding residues [chemical binding]; other site 1179773010271 dimer interface [polypeptide binding]; other site 1179773010272 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1179773010273 active site 1179773010274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773010275 active site 1179773010276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773010277 putative DNA binding site [nucleotide binding]; other site 1179773010278 dimerization interface [polypeptide binding]; other site 1179773010279 putative Zn2+ binding site [ion binding]; other site 1179773010280 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773010281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773010282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773010283 Cytochrome P450; Region: p450; cl12078 1179773010284 Restriction endonuclease; Region: Mrr_cat; pfam04471 1179773010285 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1179773010286 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773010287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773010288 catalytic residue [active] 1179773010289 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773010290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010291 Walker A/P-loop; other site 1179773010292 ATP binding site [chemical binding]; other site 1179773010293 Q-loop/lid; other site 1179773010294 ABC transporter signature motif; other site 1179773010295 Walker B; other site 1179773010296 D-loop; other site 1179773010297 H-loop/switch region; other site 1179773010298 FtsX-like permease family; Region: FtsX; pfam02687 1179773010299 FtsX-like permease family; Region: FtsX; pfam02687 1179773010300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773010301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773010302 Walker A/P-loop; other site 1179773010303 ATP binding site [chemical binding]; other site 1179773010304 Q-loop/lid; other site 1179773010305 ABC transporter signature motif; other site 1179773010306 Walker B; other site 1179773010307 D-loop; other site 1179773010308 H-loop/switch region; other site 1179773010309 Histidine kinase; Region: HisKA_3; pfam07730 1179773010310 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773010311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773010313 active site 1179773010314 phosphorylation site [posttranslational modification] 1179773010315 intermolecular recognition site; other site 1179773010316 dimerization interface [polypeptide binding]; other site 1179773010317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010318 DNA binding residues [nucleotide binding] 1179773010319 dimerization interface [polypeptide binding]; other site 1179773010320 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1179773010321 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1179773010322 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773010323 FAD binding pocket [chemical binding]; other site 1179773010324 FAD binding motif [chemical binding]; other site 1179773010325 phosphate binding motif [ion binding]; other site 1179773010326 NAD binding pocket [chemical binding]; other site 1179773010327 Protein of unknown function (DUF419); Region: DUF419; cl15265 1179773010328 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773010329 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773010330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1179773010331 binding surface 1179773010332 TPR motif; other site 1179773010333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773010334 Fic family protein [Function unknown]; Region: COG3177 1179773010335 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1179773010336 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773010337 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1179773010338 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1179773010339 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773010340 metal ion-dependent adhesion site (MIDAS); other site 1179773010341 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1179773010342 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1179773010343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010345 dimerization interface [polypeptide binding]; other site 1179773010346 DNA binding residues [nucleotide binding] 1179773010347 hypothetical protein; Provisional; Region: PRK06834 1179773010348 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773010349 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773010350 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 1179773010351 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773010352 active site 1179773010353 hypothetical protein; Provisional; Region: PRK06834 1179773010354 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 1179773010355 short chain dehydrogenase; Provisional; Region: PRK12746 1179773010356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010357 NAD(P) binding site [chemical binding]; other site 1179773010358 active site 1179773010359 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773010360 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773010361 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1179773010362 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773010363 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1179773010364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010365 NAD(P) binding site [chemical binding]; other site 1179773010366 active site 1179773010367 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773010368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010369 active site 1179773010370 O-methyltransferase; Region: Methyltransf_2; pfam00891 1179773010371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010373 DNA binding residues [nucleotide binding] 1179773010374 dimerization interface [polypeptide binding]; other site 1179773010375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773010376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773010377 GtrA-like protein; Region: GtrA; pfam04138 1179773010378 Predicted membrane protein [Function unknown]; Region: COG2246 1179773010379 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1179773010380 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1179773010381 Ligand binding site; other site 1179773010382 Putative Catalytic site; other site 1179773010383 DXD motif; other site 1179773010384 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1179773010385 CHAT domain; Region: CHAT; cl17868 1179773010386 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1179773010387 active site 1179773010388 catalytic residues [active] 1179773010389 Pirin-related protein [General function prediction only]; Region: COG1741 1179773010390 Pirin; Region: Pirin; pfam02678 1179773010391 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1179773010392 Sulfatase; Region: Sulfatase; cl17466 1179773010393 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1179773010394 RibD C-terminal domain; Region: RibD_C; cl17279 1179773010395 DoxX-like family; Region: DoxX_2; pfam13564 1179773010396 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1179773010397 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773010398 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1179773010399 putative NAD(P) binding site [chemical binding]; other site 1179773010400 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1179773010401 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1179773010402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773010403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773010404 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1179773010405 active site 1179773010406 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1179773010407 dimerization interface [polypeptide binding]; other site 1179773010408 active site 1179773010409 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1179773010410 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1179773010411 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773010412 acyl-activating enzyme (AAE) consensus motif; other site 1179773010413 CoA binding site [chemical binding]; other site 1179773010414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773010415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773010416 Coenzyme A binding pocket [chemical binding]; other site 1179773010417 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773010418 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773010419 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1179773010420 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 1179773010421 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1179773010422 active site 1179773010423 zinc binding site [ion binding]; other site 1179773010424 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773010425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010426 Walker A/P-loop; other site 1179773010427 ATP binding site [chemical binding]; other site 1179773010428 Q-loop/lid; other site 1179773010429 ABC transporter signature motif; other site 1179773010430 Walker B; other site 1179773010431 D-loop; other site 1179773010432 H-loop/switch region; other site 1179773010433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773010434 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773010435 Berberine and berberine like; Region: BBE; pfam08031 1179773010436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773010437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773010438 S-adenosylmethionine binding site [chemical binding]; other site 1179773010439 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773010440 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773010441 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773010442 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773010443 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773010444 Bacterial Ig-like domain; Region: Big_5; pfam13205 1179773010445 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1179773010446 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1179773010447 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1179773010448 putative dimer interface [polypeptide binding]; other site 1179773010449 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773010450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010451 putative substrate translocation pore; other site 1179773010452 Cytochrome P450; Region: p450; cl12078 1179773010453 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773010454 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1179773010455 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773010456 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773010457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773010458 ligand binding site [chemical binding]; other site 1179773010459 flexible hinge region; other site 1179773010460 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1179773010461 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773010462 Predicted ATPase [General function prediction only]; Region: COG3903 1179773010463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773010464 binding surface 1179773010465 TPR motif; other site 1179773010466 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773010467 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773010468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010469 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773010470 Walker A/P-loop; other site 1179773010471 ATP binding site [chemical binding]; other site 1179773010472 Q-loop/lid; other site 1179773010473 ABC transporter signature motif; other site 1179773010474 Walker B; other site 1179773010475 D-loop; other site 1179773010476 H-loop/switch region; other site 1179773010477 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773010478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773010479 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773010480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773010481 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1179773010482 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773010483 NAD(P) binding site [chemical binding]; other site 1179773010484 catalytic residues [active] 1179773010485 O-methyltransferase; Region: Methyltransf_2; pfam00891 1179773010486 sugar efflux transporter; Region: 2A0120; TIGR00899 1179773010487 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773010488 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773010489 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1179773010490 Walker A/P-loop; other site 1179773010491 ATP binding site [chemical binding]; other site 1179773010492 Q-loop/lid; other site 1179773010493 ABC transporter signature motif; other site 1179773010494 Walker B; other site 1179773010495 D-loop; other site 1179773010496 H-loop/switch region; other site 1179773010497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773010499 Walker A/P-loop; other site 1179773010500 ATP binding site [chemical binding]; other site 1179773010501 Q-loop/lid; other site 1179773010502 ABC transporter signature motif; other site 1179773010503 Walker B; other site 1179773010504 D-loop; other site 1179773010505 H-loop/switch region; other site 1179773010506 Cobalt transport protein; Region: CbiQ; cl00463 1179773010507 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773010508 Cytochrome P450; Region: p450; cl12078 1179773010509 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773010510 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1179773010511 intersubunit interface [polypeptide binding]; other site 1179773010512 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1179773010513 EamA-like transporter family; Region: EamA; pfam00892 1179773010514 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773010515 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773010516 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773010517 calcium binding site 2 [ion binding]; other site 1179773010518 active site 1179773010519 catalytic triad [active] 1179773010520 calcium binding site 1 [ion binding]; other site 1179773010521 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1179773010522 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1179773010523 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1179773010524 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773010525 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773010526 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773010527 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773010528 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773010529 FAD binding pocket [chemical binding]; other site 1179773010530 FAD binding motif [chemical binding]; other site 1179773010531 phosphate binding motif [ion binding]; other site 1179773010532 NAD binding pocket [chemical binding]; other site 1179773010533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010534 Walker A/P-loop; other site 1179773010535 ATP binding site [chemical binding]; other site 1179773010536 Q-loop/lid; other site 1179773010537 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1179773010538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773010539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773010540 Walker A/P-loop; other site 1179773010541 ATP binding site [chemical binding]; other site 1179773010542 Q-loop/lid; other site 1179773010543 ABC transporter signature motif; other site 1179773010544 Walker B; other site 1179773010545 D-loop; other site 1179773010546 H-loop/switch region; other site 1179773010547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010548 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773010549 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1179773010550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773010551 S-adenosylmethionine binding site [chemical binding]; other site 1179773010552 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773010553 DinB superfamily; Region: DinB_2; pfam12867 1179773010554 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773010555 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773010556 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773010557 SNF2 Helicase protein; Region: DUF3670; pfam12419 1179773010558 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1179773010559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773010560 ATP binding site [chemical binding]; other site 1179773010561 putative Mg++ binding site [ion binding]; other site 1179773010562 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1179773010563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773010564 nucleotide binding region [chemical binding]; other site 1179773010565 ATP-binding site [chemical binding]; other site 1179773010566 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1179773010567 SWIM zinc finger; Region: SWIM; pfam04434 1179773010568 Domain of unknown function (DUF955); Region: DUF955; cl01076 1179773010569 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773010570 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773010571 active site 1179773010572 catalytic tetrad [active] 1179773010573 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773010574 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1179773010575 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1179773010576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773010577 catalytic core [active] 1179773010578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773010579 active site 1179773010580 DNA binding site [nucleotide binding] 1179773010581 Int/Topo IB signature motif; other site 1179773010582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773010583 dimerization interface [polypeptide binding]; other site 1179773010584 putative DNA binding site [nucleotide binding]; other site 1179773010585 putative Zn2+ binding site [ion binding]; other site 1179773010586 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1179773010587 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773010588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773010589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773010590 DNA binding residues [nucleotide binding] 1179773010591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1179773010592 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1179773010593 SnoaL-like domain; Region: SnoaL_3; pfam13474 1179773010594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773010595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773010596 DNA-binding site [nucleotide binding]; DNA binding site 1179773010597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773010598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773010599 homodimer interface [polypeptide binding]; other site 1179773010600 catalytic residue [active] 1179773010601 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1179773010602 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1179773010603 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1179773010604 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1179773010605 oligomerization interface [polypeptide binding]; other site 1179773010606 active site 1179773010607 metal binding site [ion binding]; metal-binding site 1179773010608 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1179773010609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773010610 ATP binding site [chemical binding]; other site 1179773010611 putative Mg++ binding site [ion binding]; other site 1179773010612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773010613 nucleotide binding region [chemical binding]; other site 1179773010614 ATP-binding site [chemical binding]; other site 1179773010615 Helicase associated domain (HA2); Region: HA2; pfam04408 1179773010616 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1179773010617 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1179773010618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773010619 amidase; Provisional; Region: PRK06170 1179773010620 Amidase; Region: Amidase; cl11426 1179773010621 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773010622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773010623 MarR family; Region: MarR; pfam01047 1179773010624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010625 NmrA-like family; Region: NmrA; pfam05368 1179773010626 NAD(P) binding site [chemical binding]; other site 1179773010627 active site 1179773010628 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773010629 cleavage site 1179773010630 active site 1179773010631 substrate binding sites [chemical binding]; other site 1179773010632 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1179773010633 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1179773010634 phosphopeptide binding site; other site 1179773010635 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773010636 metal ion-dependent adhesion site (MIDAS); other site 1179773010637 Double zinc ribbon; Region: DZR; pfam12773 1179773010638 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1179773010639 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1179773010640 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773010641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773010642 active site 1179773010643 ATP binding site [chemical binding]; other site 1179773010644 substrate binding site [chemical binding]; other site 1179773010645 activation loop (A-loop); other site 1179773010646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773010647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773010648 substrate binding pocket [chemical binding]; other site 1179773010649 membrane-bound complex binding site; other site 1179773010650 hinge residues; other site 1179773010651 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1179773010652 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773010653 active site 1179773010654 metal binding site [ion binding]; metal-binding site 1179773010655 hexamer interface [polypeptide binding]; other site 1179773010656 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1179773010657 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773010658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773010659 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1179773010660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773010661 catalytic residue [active] 1179773010662 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773010663 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773010664 NAD(P) binding site [chemical binding]; other site 1179773010665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773010666 MarR family; Region: MarR; pfam01047 1179773010667 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1179773010668 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773010669 T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; Region: TBOX; cl00145 1179773010670 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773010671 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773010672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773010673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773010674 Coenzyme A binding pocket [chemical binding]; other site 1179773010675 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1179773010676 Hemerythrin-like domain; Region: Hr-like; cd12108 1179773010677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773010679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773010681 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773010682 hypothetical protein; Provisional; Region: PRK06834 1179773010683 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773010684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773010685 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1179773010686 substrate binding site [chemical binding]; other site 1179773010687 hypothetical protein; Provisional; Region: PRK07588 1179773010688 hypothetical protein; Provisional; Region: PRK07236 1179773010689 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773010690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773010691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010692 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773010693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010695 DNA binding residues [nucleotide binding] 1179773010696 dimerization interface [polypeptide binding]; other site 1179773010697 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773010698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773010699 catalytic residue [active] 1179773010700 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773010701 AAA domain; Region: AAA_33; pfam13671 1179773010702 MarR family; Region: MarR; pfam01047 1179773010703 hypothetical protein; Provisional; Region: PRK07906 1179773010704 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1179773010705 putative metal binding site [ion binding]; other site 1179773010706 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1179773010707 SxDxEG motif; other site 1179773010708 active site 1179773010709 metal binding site [ion binding]; metal-binding site 1179773010710 homopentamer interface [polypeptide binding]; other site 1179773010711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773010712 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773010713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773010714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773010715 active site 1179773010716 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1179773010717 putative active site [active] 1179773010718 putative substrate binding site [chemical binding]; other site 1179773010719 ATP binding site [chemical binding]; other site 1179773010720 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1179773010721 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1179773010722 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773010723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773010724 motif II; other site 1179773010725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010726 NmrA-like family; Region: NmrA; pfam05368 1179773010727 NAD(P) binding site [chemical binding]; other site 1179773010728 active site 1179773010729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773010730 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773010731 Trp docking motif [polypeptide binding]; other site 1179773010732 active site 1179773010733 PQQ-like domain; Region: PQQ_2; pfam13360 1179773010734 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773010735 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1179773010736 dimer interface [polypeptide binding]; other site 1179773010737 catalytic triad [active] 1179773010738 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1179773010739 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773010740 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1179773010741 conserved hypothetical protein; Region: TIGR03843 1179773010742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773010743 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1179773010744 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1179773010745 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1179773010746 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1179773010747 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1179773010748 amidase; Provisional; Region: PRK12470 1179773010749 Amidase; Region: Amidase; cl11426 1179773010750 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773010751 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773010752 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773010753 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1179773010754 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773010755 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773010756 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773010757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773010758 glucose-1-dehydrogenase; Provisional; Region: PRK06947 1179773010759 classical (c) SDRs; Region: SDR_c; cd05233 1179773010760 NAD(P) binding site [chemical binding]; other site 1179773010761 active site 1179773010762 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1179773010763 active site 1179773010764 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773010765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773010766 non-specific DNA binding site [nucleotide binding]; other site 1179773010767 salt bridge; other site 1179773010768 sequence-specific DNA binding site [nucleotide binding]; other site 1179773010769 Predicted methyltransferase [General function prediction only]; Region: COG3897 1179773010770 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1179773010771 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773010772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773010773 MarR family; Region: MarR_2; pfam12802 1179773010774 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773010775 WYL domain; Region: WYL; pfam13280 1179773010776 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773010777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773010778 active site 1179773010779 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1179773010780 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773010781 active site 1179773010782 DNA binding site [nucleotide binding] 1179773010783 Int/Topo IB signature motif; other site 1179773010784 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1179773010785 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1179773010786 DNA binding site [nucleotide binding] 1179773010787 heterodimer interface [polypeptide binding]; other site 1179773010788 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1179773010789 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1179773010790 putative DNA binding site [nucleotide binding]; other site 1179773010791 putative homodimer interface [polypeptide binding]; other site 1179773010792 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1179773010793 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1179773010794 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1179773010795 active site 1179773010796 DNA binding site [nucleotide binding] 1179773010797 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1179773010798 DNA binding site [nucleotide binding] 1179773010799 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1179773010800 nucleotide binding site [chemical binding]; other site 1179773010801 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1179773010802 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773010803 DNA binding site [nucleotide binding] 1179773010804 AAA ATPase domain; Region: AAA_16; pfam13191 1179773010805 Predicted ATPase [General function prediction only]; Region: COG3903 1179773010806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773010807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773010808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773010809 binding surface 1179773010810 TPR motif; other site 1179773010811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773010812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010813 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773010814 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773010815 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773010816 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773010817 PAS domain S-box; Region: sensory_box; TIGR00229 1179773010818 PAS domain; Region: PAS; smart00091 1179773010819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773010820 PAS fold; Region: PAS_3; pfam08447 1179773010821 putative active site [active] 1179773010822 heme pocket [chemical binding]; other site 1179773010823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773010824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773010825 metal binding site [ion binding]; metal-binding site 1179773010826 active site 1179773010827 I-site; other site 1179773010828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773010829 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1179773010830 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1179773010831 putative active site [active] 1179773010832 catalytic site [active] 1179773010833 putative metal binding site [ion binding]; other site 1179773010834 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1179773010835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010836 putative substrate translocation pore; other site 1179773010837 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773010838 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773010839 thymidine kinase; Provisional; Region: PRK04296 1179773010840 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773010841 active site 1179773010842 oxyanion hole [active] 1179773010843 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773010844 nudix motif; other site 1179773010845 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1179773010846 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773010847 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1179773010848 Ligand binding site; other site 1179773010849 Putative Catalytic site; other site 1179773010850 DXD motif; other site 1179773010851 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1179773010852 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1179773010853 putative active site [active] 1179773010854 catalytic triad [active] 1179773010855 putative dimer interface [polypeptide binding]; other site 1179773010856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773010857 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773010858 PspC domain; Region: PspC; pfam04024 1179773010859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773010860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773010861 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773010862 Predicted transcriptional regulators [Transcription]; Region: COG1725 1179773010863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773010864 DNA-binding site [nucleotide binding]; DNA binding site 1179773010865 Part of AAA domain; Region: AAA_19; pfam13245 1179773010866 Family description; Region: UvrD_C_2; pfam13538 1179773010867 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1179773010868 active site 2 [active] 1179773010869 active site 1 [active] 1179773010870 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1179773010871 B12 binding site [chemical binding]; other site 1179773010872 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1179773010873 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1179773010874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773010875 active site 1179773010876 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773010877 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773010878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773010879 non-specific DNA binding site [nucleotide binding]; other site 1179773010880 salt bridge; other site 1179773010881 sequence-specific DNA binding site [nucleotide binding]; other site 1179773010882 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1179773010883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1179773010884 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1179773010885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773010886 ATP binding site [chemical binding]; other site 1179773010887 Mg2+ binding site [ion binding]; other site 1179773010888 G-X-G motif; other site 1179773010889 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1179773010890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773010891 active site 1179773010892 phosphorylation site [posttranslational modification] 1179773010893 intermolecular recognition site; other site 1179773010894 dimerization interface [polypeptide binding]; other site 1179773010895 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773010896 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1179773010897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1179773010898 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773010899 CAAX protease self-immunity; Region: Abi; pfam02517 1179773010900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773010901 Histidine kinase; Region: HisKA_3; pfam07730 1179773010902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773010903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773010904 active site 1179773010905 phosphorylation site [posttranslational modification] 1179773010906 intermolecular recognition site; other site 1179773010907 dimerization interface [polypeptide binding]; other site 1179773010908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773010909 DNA binding residues [nucleotide binding] 1179773010910 dimerization interface [polypeptide binding]; other site 1179773010911 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1179773010912 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1179773010913 tetramer interface [polypeptide binding]; other site 1179773010914 active site 1179773010915 Mg2+/Mn2+ binding site [ion binding]; other site 1179773010916 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1179773010917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773010918 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1179773010919 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1179773010920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1179773010921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773010922 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1179773010923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1179773010924 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773010925 metal ion-dependent adhesion site (MIDAS); other site 1179773010926 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1179773010927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773010928 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1179773010929 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1179773010930 metal binding triad [ion binding]; metal-binding site 1179773010931 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773010932 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773010933 active site 1179773010934 metal binding site [ion binding]; metal-binding site 1179773010935 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773010936 anti sigma factor interaction site; other site 1179773010937 regulatory phosphorylation site [posttranslational modification]; other site 1179773010938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773010939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773010940 dimer interface [polypeptide binding]; other site 1179773010941 phosphorylation site [posttranslational modification] 1179773010942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773010943 ATP binding site [chemical binding]; other site 1179773010944 Mg2+ binding site [ion binding]; other site 1179773010945 G-X-G motif; other site 1179773010946 Response regulator receiver domain; Region: Response_reg; pfam00072 1179773010947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773010948 active site 1179773010949 phosphorylation site [posttranslational modification] 1179773010950 intermolecular recognition site; other site 1179773010951 dimerization interface [polypeptide binding]; other site 1179773010952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773010953 PAS domain; Region: PAS_9; pfam13426 1179773010954 putative active site [active] 1179773010955 heme pocket [chemical binding]; other site 1179773010956 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773010957 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773010958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1179773010959 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773010960 anti sigma factor interaction site; other site 1179773010961 regulatory phosphorylation site [posttranslational modification]; other site 1179773010962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773010963 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773010964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773010965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773010966 DNA binding site [nucleotide binding] 1179773010967 domain linker motif; other site 1179773010968 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773010969 ligand binding site [chemical binding]; other site 1179773010970 dimerization interface [polypeptide binding]; other site 1179773010971 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773010972 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1179773010973 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773010974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773010975 putative substrate translocation pore; other site 1179773010976 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 1179773010977 nucleotide binding site [chemical binding]; other site 1179773010978 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1179773010979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773010980 Walker A motif; other site 1179773010981 ATP binding site [chemical binding]; other site 1179773010982 arginine finger; other site 1179773010983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773010984 Cytochrome P450; Region: p450; cl12078 1179773010985 Flavoprotein; Region: Flavoprotein; pfam02441 1179773010986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773010987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773010988 non-specific DNA binding site [nucleotide binding]; other site 1179773010989 salt bridge; other site 1179773010990 sequence-specific DNA binding site [nucleotide binding]; other site 1179773010991 Cupin; Region: Cupin_6; pfam12852 1179773010992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773010993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773010994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773010995 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773010996 NAD(P) binding site [chemical binding]; other site 1179773010997 active site 1179773010998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773010999 non-specific DNA binding site [nucleotide binding]; other site 1179773011000 salt bridge; other site 1179773011001 sequence-specific DNA binding site [nucleotide binding]; other site 1179773011002 Cupin domain; Region: Cupin_2; cl17218 1179773011003 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773011004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773011005 S-adenosylmethionine binding site [chemical binding]; other site 1179773011006 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773011007 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1179773011008 putative active site [active] 1179773011009 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1179773011010 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1179773011011 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1179773011012 active site 1179773011013 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1179773011014 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1179773011015 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1179773011016 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1179773011017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1179773011018 NMT1/THI5 like; Region: NMT1; pfam09084 1179773011019 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1179773011020 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773011021 Walker A/P-loop; other site 1179773011022 ATP binding site [chemical binding]; other site 1179773011023 Q-loop/lid; other site 1179773011024 ABC transporter signature motif; other site 1179773011025 Walker B; other site 1179773011026 D-loop; other site 1179773011027 H-loop/switch region; other site 1179773011028 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773011029 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1179773011030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011031 dimer interface [polypeptide binding]; other site 1179773011032 conserved gate region; other site 1179773011033 putative PBP binding loops; other site 1179773011034 ABC-ATPase subunit interface; other site 1179773011035 cytosine deaminase; Provisional; Region: PRK05985 1179773011036 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1179773011037 active site 1179773011038 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773011039 anti sigma factor interaction site; other site 1179773011040 regulatory phosphorylation site [posttranslational modification]; other site 1179773011041 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1179773011042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773011043 substrate binding pocket [chemical binding]; other site 1179773011044 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1179773011045 membrane-bound complex binding site; other site 1179773011046 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773011047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011048 dimer interface [polypeptide binding]; other site 1179773011049 conserved gate region; other site 1179773011050 putative PBP binding loops; other site 1179773011051 ABC-ATPase subunit interface; other site 1179773011052 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773011053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011054 Walker A/P-loop; other site 1179773011055 ATP binding site [chemical binding]; other site 1179773011056 Q-loop/lid; other site 1179773011057 ABC transporter signature motif; other site 1179773011058 Walker B; other site 1179773011059 D-loop; other site 1179773011060 H-loop/switch region; other site 1179773011061 NMT1/THI5 like; Region: NMT1; pfam09084 1179773011062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773011063 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773011064 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1179773011065 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1179773011066 dimer interface [polypeptide binding]; other site 1179773011067 active site 1179773011068 non-prolyl cis peptide bond; other site 1179773011069 insertion regions; other site 1179773011070 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773011071 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773011072 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773011073 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1179773011074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773011075 substrate binding pocket [chemical binding]; other site 1179773011076 membrane-bound complex binding site; other site 1179773011077 hinge residues; other site 1179773011078 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1179773011079 putative FMN binding site [chemical binding]; other site 1179773011080 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773011081 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773011082 NAD(P) binding site [chemical binding]; other site 1179773011083 catalytic residues [active] 1179773011084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773011085 dimerization interface [polypeptide binding]; other site 1179773011086 putative DNA binding site [nucleotide binding]; other site 1179773011087 putative Zn2+ binding site [ion binding]; other site 1179773011088 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773011089 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1179773011090 putative NAD(P) binding site [chemical binding]; other site 1179773011091 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773011092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773011093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773011094 DNA binding residues [nucleotide binding] 1179773011095 YCII-related domain; Region: YCII; cl00999 1179773011096 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773011097 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773011098 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1179773011099 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773011100 active site 1179773011101 ATP binding site [chemical binding]; other site 1179773011102 substrate binding site [chemical binding]; other site 1179773011103 activation loop (A-loop); other site 1179773011104 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 1179773011105 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1179773011106 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773011107 amidase; Provisional; Region: PRK08137 1179773011108 Amidase; Region: Amidase; cl11426 1179773011109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773011110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773011111 DNA binding residues [nucleotide binding] 1179773011112 dimerization interface [polypeptide binding]; other site 1179773011113 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773011114 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1179773011115 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1179773011116 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1179773011117 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1179773011118 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1179773011119 hypothetical protein; Provisional; Region: PRK06834 1179773011120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773011121 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773011122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773011123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773011124 metal binding site [ion binding]; metal-binding site 1179773011125 active site 1179773011126 I-site; other site 1179773011127 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1179773011128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1179773011129 Zn2+ binding site [ion binding]; other site 1179773011130 Mg2+ binding site [ion binding]; other site 1179773011131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773011132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773011133 Coenzyme A binding pocket [chemical binding]; other site 1179773011134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773011135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773011136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773011137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773011138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011139 Walker A/P-loop; other site 1179773011140 ATP binding site [chemical binding]; other site 1179773011141 Q-loop/lid; other site 1179773011142 ABC transporter signature motif; other site 1179773011143 Walker B; other site 1179773011144 D-loop; other site 1179773011145 H-loop/switch region; other site 1179773011146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773011147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773011148 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1179773011149 Walker A/P-loop; other site 1179773011150 ATP binding site [chemical binding]; other site 1179773011151 Q-loop/lid; other site 1179773011152 ABC transporter signature motif; other site 1179773011153 Walker B; other site 1179773011154 D-loop; other site 1179773011155 H-loop/switch region; other site 1179773011156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773011157 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773011158 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773011159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773011160 NAD(P) binding site [chemical binding]; other site 1179773011161 active site 1179773011162 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1179773011163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773011164 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1179773011165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773011166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773011167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773011168 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773011169 NAD(P) binding site [chemical binding]; other site 1179773011170 active site 1179773011171 Bacterial SH3 domain; Region: SH3_3; cl17532 1179773011172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773011173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773011174 non-specific DNA binding site [nucleotide binding]; other site 1179773011175 salt bridge; other site 1179773011176 sequence-specific DNA binding site [nucleotide binding]; other site 1179773011177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773011178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773011179 Coenzyme A binding pocket [chemical binding]; other site 1179773011180 Putative sensor; Region: Sensor; pfam13796 1179773011181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773011182 Histidine kinase; Region: HisKA_3; pfam07730 1179773011183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773011184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773011185 active site 1179773011186 phosphorylation site [posttranslational modification] 1179773011187 intermolecular recognition site; other site 1179773011188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773011189 DNA binding residues [nucleotide binding] 1179773011190 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773011191 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1179773011192 NADP binding site [chemical binding]; other site 1179773011193 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773011194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773011195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773011196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773011197 dimerization interface [polypeptide binding]; other site 1179773011198 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1179773011199 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1179773011200 short chain dehydrogenase; Provisional; Region: PRK06197 1179773011201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773011202 NAD(P) binding site [chemical binding]; other site 1179773011203 active site 1179773011204 hypothetical protein; Provisional; Region: PRK07236 1179773011205 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773011206 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773011207 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1179773011208 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773011209 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773011210 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773011211 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773011212 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1179773011213 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773011214 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773011215 putative sugar binding sites [chemical binding]; other site 1179773011216 Q-X-W motif; other site 1179773011217 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773011218 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773011219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773011220 S-adenosylmethionine binding site [chemical binding]; other site 1179773011221 LabA_like proteins; Region: LabA_like; cd06167 1179773011222 putative metal binding site [ion binding]; other site 1179773011223 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1179773011224 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773011225 RibD C-terminal domain; Region: RibD_C; cl17279 1179773011226 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1179773011227 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1179773011228 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1179773011229 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1179773011230 EamA-like transporter family; Region: EamA; pfam00892 1179773011231 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773011232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773011233 DNA-binding site [nucleotide binding]; DNA binding site 1179773011234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773011235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773011236 homodimer interface [polypeptide binding]; other site 1179773011237 catalytic residue [active] 1179773011238 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1179773011239 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1179773011240 active site 1179773011241 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1179773011242 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1179773011243 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773011244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773011245 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1179773011246 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1179773011247 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1179773011248 agmatinase; Region: agmatinase; TIGR01230 1179773011249 oligomer interface [polypeptide binding]; other site 1179773011250 putative active site [active] 1179773011251 Mn binding site [ion binding]; other site 1179773011252 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1179773011253 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1179773011254 tetrameric interface [polypeptide binding]; other site 1179773011255 NAD binding site [chemical binding]; other site 1179773011256 catalytic residues [active] 1179773011257 substrate binding site [chemical binding]; other site 1179773011258 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773011259 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773011260 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1179773011261 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773011262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773011263 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773011264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773011265 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1179773011266 DNA binding residues [nucleotide binding] 1179773011267 dimerization interface [polypeptide binding]; other site 1179773011268 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1179773011269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773011270 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1179773011271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773011272 non-specific DNA binding site [nucleotide binding]; other site 1179773011273 salt bridge; other site 1179773011274 sequence-specific DNA binding site [nucleotide binding]; other site 1179773011275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773011276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773011277 binding surface 1179773011278 TPR motif; other site 1179773011279 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773011280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773011281 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773011282 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1179773011283 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1179773011284 NAD binding site [chemical binding]; other site 1179773011285 catalytic Zn binding site [ion binding]; other site 1179773011286 substrate binding site [chemical binding]; other site 1179773011287 structural Zn binding site [ion binding]; other site 1179773011288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773011289 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1179773011290 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1179773011291 nucleotide binding pocket [chemical binding]; other site 1179773011292 K-X-D-G motif; other site 1179773011293 catalytic site [active] 1179773011294 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1179773011295 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1179773011296 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1179773011297 Dimer interface [polypeptide binding]; other site 1179773011298 BRCT sequence motif; other site 1179773011299 acetoacetate decarboxylase; Provisional; Region: PRK02265 1179773011300 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773011301 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1179773011302 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773011303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773011304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773011305 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1179773011306 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1179773011307 catalytic loop [active] 1179773011308 iron binding site [ion binding]; other site 1179773011309 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1179773011310 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1179773011311 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1179773011312 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1179773011313 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1179773011314 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1179773011315 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1179773011316 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 1179773011317 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1179773011318 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773011319 FAD binding pocket [chemical binding]; other site 1179773011320 FAD binding motif [chemical binding]; other site 1179773011321 phosphate binding motif [ion binding]; other site 1179773011322 NAD binding pocket [chemical binding]; other site 1179773011323 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1179773011324 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773011325 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773011326 Ca2+ binding site [ion binding]; other site 1179773011327 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773011328 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1179773011329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773011330 catalytic residue [active] 1179773011331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773011332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773011333 ligand binding site [chemical binding]; other site 1179773011334 flexible hinge region; other site 1179773011335 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1179773011336 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773011337 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1179773011338 putative dimer interface [polypeptide binding]; other site 1179773011339 N-terminal domain interface [polypeptide binding]; other site 1179773011340 putative substrate binding pocket (H-site) [chemical binding]; other site 1179773011341 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 1179773011342 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1179773011343 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1179773011344 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1179773011345 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773011346 active site 1179773011347 catalytic residues [active] 1179773011348 Cytochrome P450; Region: p450; cl12078 1179773011349 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773011350 Cytochrome P450; Region: p450; cl12078 1179773011351 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773011352 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773011353 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1179773011354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773011355 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773011356 NAD(P) binding site [chemical binding]; other site 1179773011357 active site 1179773011358 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1179773011359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773011360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773011361 DNA binding residues [nucleotide binding] 1179773011362 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773011363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011364 Q-loop/lid; other site 1179773011365 ABC transporter signature motif; other site 1179773011366 Walker B; other site 1179773011367 D-loop; other site 1179773011368 H-loop/switch region; other site 1179773011369 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1179773011370 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773011371 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011372 Walker A/P-loop; other site 1179773011373 ATP binding site [chemical binding]; other site 1179773011374 Q-loop/lid; other site 1179773011375 ABC transporter signature motif; other site 1179773011376 Walker B; other site 1179773011377 D-loop; other site 1179773011378 H-loop/switch region; other site 1179773011379 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773011380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773011381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011382 dimer interface [polypeptide binding]; other site 1179773011383 conserved gate region; other site 1179773011384 putative PBP binding loops; other site 1179773011385 ABC-ATPase subunit interface; other site 1179773011386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773011387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011388 dimer interface [polypeptide binding]; other site 1179773011389 conserved gate region; other site 1179773011390 ABC-ATPase subunit interface; other site 1179773011391 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773011392 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1179773011393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773011394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773011395 DNA binding site [nucleotide binding] 1179773011396 domain linker motif; other site 1179773011397 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773011398 dimerization interface [polypeptide binding]; other site 1179773011399 ligand binding site [chemical binding]; other site 1179773011400 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773011401 catalytic triad [active] 1179773011402 conserved cis-peptide bond; other site 1179773011403 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1179773011404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1179773011405 motif II; other site 1179773011406 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1179773011407 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1179773011408 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1179773011409 active site 1179773011410 Mn binding site [ion binding]; other site 1179773011411 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1179773011412 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1179773011413 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1179773011414 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1179773011415 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1179773011416 dimer interface [polypeptide binding]; other site 1179773011417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773011418 catalytic residue [active] 1179773011419 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1179773011420 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1179773011421 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1179773011422 NADP binding site [chemical binding]; other site 1179773011423 substrate binding site [chemical binding]; other site 1179773011424 active site 1179773011425 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773011426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773011427 putative DNA binding site [nucleotide binding]; other site 1179773011428 putative Zn2+ binding site [ion binding]; other site 1179773011429 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1179773011430 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1179773011431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773011432 catalytic residue [active] 1179773011433 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1179773011434 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773011435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773011436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011437 Walker A/P-loop; other site 1179773011438 ATP binding site [chemical binding]; other site 1179773011439 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1179773011440 Q-loop/lid; other site 1179773011441 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1179773011442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011443 Walker A/P-loop; other site 1179773011444 ATP binding site [chemical binding]; other site 1179773011445 Q-loop/lid; other site 1179773011446 ABC transporter signature motif; other site 1179773011447 Walker B; other site 1179773011448 D-loop; other site 1179773011449 H-loop/switch region; other site 1179773011450 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773011451 HTH domain; Region: HTH_11; pfam08279 1179773011452 WYL domain; Region: WYL; pfam13280 1179773011453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773011454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773011455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773011456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773011457 active site 1179773011458 phosphorylation site [posttranslational modification] 1179773011459 intermolecular recognition site; other site 1179773011460 dimerization interface [polypeptide binding]; other site 1179773011461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773011462 DNA binding site [nucleotide binding] 1179773011463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773011464 dimerization interface [polypeptide binding]; other site 1179773011465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773011466 dimer interface [polypeptide binding]; other site 1179773011467 phosphorylation site [posttranslational modification] 1179773011468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773011469 ATP binding site [chemical binding]; other site 1179773011470 G-X-G motif; other site 1179773011471 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1179773011472 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773011473 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1179773011474 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1179773011475 propionate/acetate kinase; Provisional; Region: PRK12379 1179773011476 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1179773011477 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1179773011478 ANTAR domain; Region: ANTAR; pfam03861 1179773011479 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1179773011480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773011481 ATP binding site [chemical binding]; other site 1179773011482 putative Mg++ binding site [ion binding]; other site 1179773011483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773011484 nucleotide binding region [chemical binding]; other site 1179773011485 ATP-binding site [chemical binding]; other site 1179773011486 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1179773011487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773011488 S-adenosylmethionine binding site [chemical binding]; other site 1179773011489 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773011490 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773011491 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773011492 acyl-activating enzyme (AAE) consensus motif; other site 1179773011493 AMP binding site [chemical binding]; other site 1179773011494 Condensation domain; Region: Condensation; pfam00668 1179773011495 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773011496 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773011497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773011498 acyl-activating enzyme (AAE) consensus motif; other site 1179773011499 AMP binding site [chemical binding]; other site 1179773011500 active site 1179773011501 CoA binding site [chemical binding]; other site 1179773011502 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011503 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773011504 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1179773011505 putative NAD(P) binding site [chemical binding]; other site 1179773011506 active site 1179773011507 putative substrate binding site [chemical binding]; other site 1179773011508 MbtH-like protein; Region: MbtH; pfam03621 1179773011509 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1179773011510 putative pectinesterase; Region: PLN02432; cl01911 1179773011511 Right handed beta helix region; Region: Beta_helix; pfam13229 1179773011512 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1179773011513 Spherulation-specific family 4; Region: Spherulin4; pfam12138 1179773011514 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773011515 Interdomain contacts; other site 1179773011516 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773011517 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773011518 Walker A/P-loop; other site 1179773011519 ATP binding site [chemical binding]; other site 1179773011520 Q-loop/lid; other site 1179773011521 ABC transporter signature motif; other site 1179773011522 Walker B; other site 1179773011523 D-loop; other site 1179773011524 H-loop/switch region; other site 1179773011525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1179773011526 ABC-ATPase subunit interface; other site 1179773011527 dimer interface [polypeptide binding]; other site 1179773011528 putative PBP binding regions; other site 1179773011529 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1179773011530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773011531 ABC-ATPase subunit interface; other site 1179773011532 dimer interface [polypeptide binding]; other site 1179773011533 putative PBP binding regions; other site 1179773011534 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773011535 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773011536 intersubunit interface [polypeptide binding]; other site 1179773011537 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1179773011538 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1179773011539 FAD binding pocket [chemical binding]; other site 1179773011540 FAD binding motif [chemical binding]; other site 1179773011541 phosphate binding motif [ion binding]; other site 1179773011542 NAD binding pocket [chemical binding]; other site 1179773011543 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773011544 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773011545 catalytic triad [active] 1179773011546 conserved cis-peptide bond; other site 1179773011547 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773011548 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773011549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773011550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773011551 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1179773011552 putative substrate binding pocket [chemical binding]; other site 1179773011553 putative dimerization interface [polypeptide binding]; other site 1179773011554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773011556 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773011557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773011558 putative substrate translocation pore; other site 1179773011559 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1179773011560 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773011561 phosphate binding site [ion binding]; other site 1179773011562 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1179773011563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773011564 phosphate binding site [ion binding]; other site 1179773011565 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1179773011566 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011567 active site 1179773011568 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1179773011569 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773011570 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773011571 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773011572 putative NADP binding site [chemical binding]; other site 1179773011573 active site 1179773011574 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011575 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1179773011576 active site 1179773011577 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1179773011578 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1179773011579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773011580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773011581 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773011582 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773011583 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773011584 active site 1179773011585 TDP-binding site; other site 1179773011586 acceptor substrate-binding pocket; other site 1179773011587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011588 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773011589 Walker A/P-loop; other site 1179773011590 ATP binding site [chemical binding]; other site 1179773011591 Q-loop/lid; other site 1179773011592 ABC transporter signature motif; other site 1179773011593 Walker B; other site 1179773011594 D-loop; other site 1179773011595 H-loop/switch region; other site 1179773011596 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773011597 active site 1179773011598 catalytic triad [active] 1179773011599 oxyanion hole [active] 1179773011600 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1179773011601 B12 binding site [chemical binding]; other site 1179773011602 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1179773011603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773011604 FeS/SAM binding site; other site 1179773011605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773011606 S-adenosylmethionine binding site [chemical binding]; other site 1179773011607 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1179773011608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011609 Walker A/P-loop; other site 1179773011610 ATP binding site [chemical binding]; other site 1179773011611 Q-loop/lid; other site 1179773011612 ABC transporter signature motif; other site 1179773011613 Walker B; other site 1179773011614 D-loop; other site 1179773011615 H-loop/switch region; other site 1179773011616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011617 Walker A/P-loop; other site 1179773011618 ATP binding site [chemical binding]; other site 1179773011619 Q-loop/lid; other site 1179773011620 ABC transporter signature motif; other site 1179773011621 Walker B; other site 1179773011622 D-loop; other site 1179773011623 H-loop/switch region; other site 1179773011624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773011625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011626 putative PBP binding loops; other site 1179773011627 ABC-ATPase subunit interface; other site 1179773011628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773011629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011630 conserved gate region; other site 1179773011631 putative PBP binding loops; other site 1179773011632 ABC-ATPase subunit interface; other site 1179773011633 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773011634 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1179773011635 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773011636 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773011637 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1179773011638 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773011639 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773011640 active site 1179773011641 acyl carrier protein; Validated; Region: PRK07117 1179773011642 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1179773011643 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773011644 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773011645 acyl-activating enzyme (AAE) consensus motif; other site 1179773011646 AMP binding site [chemical binding]; other site 1179773011647 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011648 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1179773011649 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773011650 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773011651 phosphate binding site [ion binding]; other site 1179773011652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011653 Condensation domain; Region: Condensation; pfam00668 1179773011654 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773011655 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1179773011656 Condensation domain; Region: Condensation; pfam00668 1179773011657 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1179773011658 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773011659 acyl-activating enzyme (AAE) consensus motif; other site 1179773011660 AMP binding site [chemical binding]; other site 1179773011661 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773011662 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1179773011663 putative FMN binding site [chemical binding]; other site 1179773011664 NADPH bind site [chemical binding]; other site 1179773011665 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011666 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011667 active site 1179773011668 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1179773011669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773011670 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1179773011671 inhibitor-cofactor binding pocket; inhibition site 1179773011672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773011673 catalytic residue [active] 1179773011674 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773011675 Cytochrome P450; Region: p450; cl12078 1179773011676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011677 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773011678 Walker A/P-loop; other site 1179773011679 ATP binding site [chemical binding]; other site 1179773011680 Q-loop/lid; other site 1179773011681 ABC transporter signature motif; other site 1179773011682 Walker B; other site 1179773011683 D-loop; other site 1179773011684 H-loop/switch region; other site 1179773011685 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773011686 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773011687 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1179773011688 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1179773011689 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1179773011690 dimer interface [polypeptide binding]; other site 1179773011691 active site 1179773011692 acyl carrier protein; Validated; Region: PRK07117 1179773011693 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1179773011694 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773011695 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773011696 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773011697 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773011698 putative NADP binding site [chemical binding]; other site 1179773011699 active site 1179773011700 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011701 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011702 active site 1179773011703 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1179773011704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773011705 substrate binding site [chemical binding]; other site 1179773011706 oxyanion hole (OAH) forming residues; other site 1179773011707 trimer interface [polypeptide binding]; other site 1179773011708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011709 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011710 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011711 active site 1179773011712 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773011713 putative NADP binding site [chemical binding]; other site 1179773011714 KR domain; Region: KR; pfam08659 1179773011715 active site 1179773011716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773011717 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773011718 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773011719 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011720 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011721 active site 1179773011722 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773011723 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773011724 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773011725 putative NADP binding site [chemical binding]; other site 1179773011726 active site 1179773011727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011728 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011730 active site 1179773011731 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011732 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1179773011733 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773011734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773011735 catalytic residue [active] 1179773011736 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773011737 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011738 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011739 active site 1179773011740 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773011741 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773011742 putative NADP binding site [chemical binding]; other site 1179773011743 active site 1179773011744 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773011745 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773011746 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773011747 active site 1179773011748 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1179773011749 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1179773011750 dimer interface [polypeptide binding]; other site 1179773011751 active site 1179773011752 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1179773011753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773011754 substrate binding site [chemical binding]; other site 1179773011755 oxyanion hole (OAH) forming residues; other site 1179773011756 trimer interface [polypeptide binding]; other site 1179773011757 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773011758 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1179773011759 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773011760 phosphate binding site [ion binding]; other site 1179773011761 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1179773011762 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773011763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773011764 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773011765 acyl-activating enzyme (AAE) consensus motif; other site 1179773011766 acyl-activating enzyme (AAE) consensus motif; other site 1179773011767 AMP binding site [chemical binding]; other site 1179773011768 active site 1179773011769 CoA binding site [chemical binding]; other site 1179773011770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773011771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773011772 ligand binding site [chemical binding]; other site 1179773011773 flexible hinge region; other site 1179773011774 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1179773011775 active site 1179773011776 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773011777 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1179773011778 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1179773011779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773011780 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773011781 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1179773011782 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1179773011783 Amidase; Region: Amidase; cl11426 1179773011784 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773011785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773011786 ligand binding site [chemical binding]; other site 1179773011787 flexible hinge region; other site 1179773011788 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1179773011789 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773011790 substrate binding site [chemical binding]; other site 1179773011791 ATP binding site [chemical binding]; other site 1179773011792 Survival protein SurE; Region: SurE; cl00448 1179773011793 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1179773011794 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773011795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773011796 dimerization interface [polypeptide binding]; other site 1179773011797 putative DNA binding site [nucleotide binding]; other site 1179773011798 putative Zn2+ binding site [ion binding]; other site 1179773011799 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1179773011800 putative hydrophobic ligand binding site [chemical binding]; other site 1179773011801 RibD C-terminal domain; Region: RibD_C; cl17279 1179773011802 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773011803 HTH domain; Region: HTH_11; pfam08279 1179773011804 WYL domain; Region: WYL; pfam13280 1179773011805 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1179773011806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773011807 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773011808 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773011809 putative sugar binding sites [chemical binding]; other site 1179773011810 Q-X-W motif; other site 1179773011811 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773011812 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773011813 putative sugar binding sites [chemical binding]; other site 1179773011814 Q-X-W motif; other site 1179773011815 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773011816 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773011817 putative sugar binding sites [chemical binding]; other site 1179773011818 Q-X-W motif; other site 1179773011819 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1179773011820 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1179773011821 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773011822 conserved cys residue [active] 1179773011823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773011824 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1179773011825 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1179773011826 PYR/PP interface [polypeptide binding]; other site 1179773011827 dimer interface [polypeptide binding]; other site 1179773011828 TPP binding site [chemical binding]; other site 1179773011829 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773011830 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1179773011831 TPP-binding site [chemical binding]; other site 1179773011832 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1179773011833 Cupin domain; Region: Cupin_2; pfam07883 1179773011834 OsmC-like protein; Region: OsmC; cl00767 1179773011835 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773011836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773011837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773011838 catalytic residue [active] 1179773011839 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1179773011840 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1179773011841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773011842 non-specific DNA binding site [nucleotide binding]; other site 1179773011843 salt bridge; other site 1179773011844 sequence-specific DNA binding site [nucleotide binding]; other site 1179773011845 Cupin domain; Region: Cupin_2; pfam07883 1179773011846 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1179773011847 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773011848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773011849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011850 dimer interface [polypeptide binding]; other site 1179773011851 conserved gate region; other site 1179773011852 putative PBP binding loops; other site 1179773011853 ABC-ATPase subunit interface; other site 1179773011854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773011855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773011856 ABC-ATPase subunit interface; other site 1179773011857 putative PBP binding loops; other site 1179773011858 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773011859 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1179773011860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011861 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773011862 Walker A/P-loop; other site 1179773011863 ATP binding site [chemical binding]; other site 1179773011864 Q-loop/lid; other site 1179773011865 ABC transporter signature motif; other site 1179773011866 Walker B; other site 1179773011867 D-loop; other site 1179773011868 H-loop/switch region; other site 1179773011869 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773011870 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773011871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773011872 Walker A/P-loop; other site 1179773011873 ATP binding site [chemical binding]; other site 1179773011874 Q-loop/lid; other site 1179773011875 ABC transporter signature motif; other site 1179773011876 Walker B; other site 1179773011877 D-loop; other site 1179773011878 H-loop/switch region; other site 1179773011879 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773011880 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773011881 active site 1179773011882 ATP binding site [chemical binding]; other site 1179773011883 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773011884 substrate binding site [chemical binding]; other site 1179773011885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773011886 Mg2+ binding site [ion binding]; other site 1179773011887 G-X-G motif; other site 1179773011888 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1179773011889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773011890 putative substrate translocation pore; other site 1179773011891 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773011892 active site 1179773011893 metal binding site [ion binding]; metal-binding site 1179773011894 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1179773011895 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773011896 putative sugar binding sites [chemical binding]; other site 1179773011897 Q-X-W motif; other site 1179773011898 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1179773011899 hypothetical protein; Provisional; Region: PRK08244 1179773011900 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1179773011901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773011902 binding surface 1179773011903 TPR motif; other site 1179773011904 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1179773011905 probable polyamine oxidase; Region: PLN02268 1179773011906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773011907 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773011908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773011909 ligand binding site [chemical binding]; other site 1179773011910 flexible hinge region; other site 1179773011911 short chain dehydrogenase; Provisional; Region: PRK06523 1179773011912 classical (c) SDRs; Region: SDR_c; cd05233 1179773011913 NAD(P) binding site [chemical binding]; other site 1179773011914 active site 1179773011915 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773011916 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1179773011917 NAD(P) binding site [chemical binding]; other site 1179773011918 catalytic residues [active] 1179773011919 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1179773011920 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773011921 hypothetical protein; Provisional; Region: PRK08204 1179773011922 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773011923 active site 1179773011924 hypothetical protein; Provisional; Region: PRK08244 1179773011925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773011926 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1179773011927 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773011928 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1179773011929 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1179773011930 active site 1179773011931 dimer interface [polypeptide binding]; other site 1179773011932 metal binding site [ion binding]; metal-binding site 1179773011933 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1179773011934 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1179773011935 dimer interface [polypeptide binding]; other site 1179773011936 active site 1179773011937 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773011938 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773011939 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773011940 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773011941 Amidohydrolase; Region: Amidohydro_2; pfam04909 1179773011942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773011943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773011944 putative substrate translocation pore; other site 1179773011945 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1179773011946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773011947 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1179773011948 active site flap/lid [active] 1179773011949 nucleophilic elbow; other site 1179773011950 catalytic triad [active] 1179773011951 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 1179773011952 active site 1179773011953 catalytic site [active] 1179773011954 alpha-glucosidase; Provisional; Region: PRK10137 1179773011955 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1179773011956 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1179773011957 Ion transport protein; Region: Ion_trans; pfam00520 1179773011958 CHAT domain; Region: CHAT; cl17868 1179773011959 AAA domain; Region: AAA_22; pfam13401 1179773011960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773011961 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1179773011962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773011963 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773011964 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1179773011965 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773011966 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1179773011967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773011968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773011969 ATP binding site [chemical binding]; other site 1179773011970 Mg2+ binding site [ion binding]; other site 1179773011971 G-X-G motif; other site 1179773011972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773011973 Walker A/P-loop; other site 1179773011974 ATP binding site [chemical binding]; other site 1179773011975 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773011976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773011977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1179773011978 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1179773011979 Walker A/P-loop; other site 1179773011980 ATP binding site [chemical binding]; other site 1179773011981 Q-loop/lid; other site 1179773011982 ABC transporter signature motif; other site 1179773011983 Walker B; other site 1179773011984 D-loop; other site 1179773011985 H-loop/switch region; other site 1179773011986 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1179773011987 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1179773011988 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1179773011989 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773011990 hydrophobic ligand binding site; other site 1179773011991 AAA ATPase domain; Region: AAA_16; pfam13191 1179773011992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773011993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773011994 DNA binding residues [nucleotide binding] 1179773011995 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773011996 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773011997 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773011998 calcium binding site 2 [ion binding]; other site 1179773011999 active site 1179773012000 catalytic triad [active] 1179773012001 calcium binding site 1 [ion binding]; other site 1179773012002 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012003 Cytochrome P450; Region: p450; cl12078 1179773012004 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1179773012005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773012006 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773012007 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1179773012008 Erythronolide synthase docking; Region: Docking; pfam08990 1179773012009 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012010 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012011 active site 1179773012012 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012013 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012014 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012015 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012016 putative NADP binding site [chemical binding]; other site 1179773012017 active site 1179773012018 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012019 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773012020 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1179773012021 putative NAD(P) binding site [chemical binding]; other site 1179773012022 active site 1179773012023 putative substrate binding site [chemical binding]; other site 1179773012024 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012025 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012026 active site 1179773012027 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012028 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012030 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012031 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012032 putative NADP binding site [chemical binding]; other site 1179773012033 active site 1179773012034 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012035 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773012036 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1179773012037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773012038 catalytic residue [active] 1179773012039 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012040 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1179773012041 active site 1179773012042 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012043 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012044 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012045 active site 1179773012046 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012047 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1179773012048 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012049 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012050 putative NADP binding site [chemical binding]; other site 1179773012051 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012052 active site 1179773012053 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012054 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012055 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012056 active site 1179773012057 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012058 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012059 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012060 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012061 putative NADP binding site [chemical binding]; other site 1179773012062 active site 1179773012063 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012064 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012065 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012066 active site 1179773012067 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012068 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012069 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012070 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012071 putative NADP binding site [chemical binding]; other site 1179773012072 active site 1179773012073 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012074 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773012075 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1179773012076 metal binding site [ion binding]; metal-binding site 1179773012077 AAA ATPase domain; Region: AAA_16; pfam13191 1179773012078 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1179773012079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773012080 Walker A/P-loop; other site 1179773012081 ATP binding site [chemical binding]; other site 1179773012082 Q-loop/lid; other site 1179773012083 ABC transporter signature motif; other site 1179773012084 Walker B; other site 1179773012085 D-loop; other site 1179773012086 H-loop/switch region; other site 1179773012087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773012088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773012089 Walker A/P-loop; other site 1179773012090 ATP binding site [chemical binding]; other site 1179773012091 Q-loop/lid; other site 1179773012092 ABC transporter signature motif; other site 1179773012093 Walker B; other site 1179773012094 D-loop; other site 1179773012095 H-loop/switch region; other site 1179773012096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773012097 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773012098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773012099 putative PBP binding loops; other site 1179773012100 dimer interface [polypeptide binding]; other site 1179773012101 ABC-ATPase subunit interface; other site 1179773012102 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773012103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773012104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773012105 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1179773012106 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773012107 SnoaL-like domain; Region: SnoaL_4; pfam13577 1179773012108 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1179773012109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773012110 classical (c) SDRs; Region: SDR_c; cd05233 1179773012111 NAD(P) binding site [chemical binding]; other site 1179773012112 active site 1179773012113 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012114 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012115 active site 1179773012116 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012117 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012118 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012119 putative NADP binding site [chemical binding]; other site 1179773012120 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012121 active site 1179773012122 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012123 Thioesterase; Region: PKS_TE; smart00824 1179773012124 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012125 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012126 active site 1179773012127 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012128 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012129 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012130 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012131 putative NADP binding site [chemical binding]; other site 1179773012132 active site 1179773012133 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012134 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012135 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012136 active site 1179773012137 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012138 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012139 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012140 Erythronolide synthase docking; Region: Docking; pfam08990 1179773012141 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012142 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012143 active site 1179773012144 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012145 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012146 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 1179773012147 NADP binding site [chemical binding]; other site 1179773012148 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012149 active site 1179773012150 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012151 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012152 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012153 active site 1179773012154 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012155 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012156 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012157 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012158 active site 1179773012159 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012160 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012161 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012162 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012163 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012164 putative NADP binding site [chemical binding]; other site 1179773012165 active site 1179773012166 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012167 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773012168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773012169 DNA binding residues [nucleotide binding] 1179773012170 dimerization interface [polypeptide binding]; other site 1179773012171 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1179773012172 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773012173 anti sigma factor interaction site; other site 1179773012174 regulatory phosphorylation site [posttranslational modification]; other site 1179773012175 Transmembrane secretion effector; Region: MFS_3; pfam05977 1179773012176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773012177 putative substrate translocation pore; other site 1179773012178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773012179 anti sigma factor interaction site; other site 1179773012180 regulatory phosphorylation site [posttranslational modification]; other site 1179773012181 Cytochrome P450; Region: p450; cl12078 1179773012182 Cytochrome P450; Region: p450; cl12078 1179773012183 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1179773012184 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1179773012185 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1179773012186 active site 1179773012187 DNA binding site [nucleotide binding] 1179773012188 Int/Topo IB signature motif; other site 1179773012189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773012190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773012191 Coenzyme A binding pocket [chemical binding]; other site 1179773012192 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773012193 cleavage site 1179773012194 active site 1179773012195 substrate binding sites [chemical binding]; other site 1179773012196 Predicted membrane protein [Function unknown]; Region: COG2246 1179773012197 GtrA-like protein; Region: GtrA; pfam04138 1179773012198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773012199 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773012200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012201 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773012202 NAD(P) binding site [chemical binding]; other site 1179773012203 active site 1179773012204 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1179773012205 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773012206 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1179773012207 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773012208 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1179773012209 active site 1179773012210 TDP-binding site; other site 1179773012211 acceptor substrate-binding pocket; other site 1179773012212 homodimer interface [polypeptide binding]; other site 1179773012213 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773012214 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773012215 inhibitor-cofactor binding pocket; inhibition site 1179773012216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773012217 catalytic residue [active] 1179773012218 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012219 Cytochrome P450; Region: p450; cl12078 1179773012220 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773012221 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773012222 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773012223 structural tetrad; other site 1179773012224 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773012225 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773012226 structural tetrad; other site 1179773012227 Condensation domain; Region: Condensation; pfam00668 1179773012228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773012229 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773012230 acyl-activating enzyme (AAE) consensus motif; other site 1179773012231 AMP binding site [chemical binding]; other site 1179773012232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012233 Condensation domain; Region: Condensation; pfam00668 1179773012234 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773012235 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773012236 acyl-activating enzyme (AAE) consensus motif; other site 1179773012237 AMP binding site [chemical binding]; other site 1179773012238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012239 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1179773012240 hypothetical protein; Provisional; Region: PRK06753 1179773012241 hypothetical protein; Provisional; Region: PRK07236 1179773012242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773012243 Condensation domain; Region: Condensation; pfam00668 1179773012244 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1179773012245 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012246 NADP binding site [chemical binding]; other site 1179773012247 active site 1179773012248 steroid binding site; other site 1179773012249 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012250 Cytochrome P450; Region: p450; cl12078 1179773012251 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773012252 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773012253 putative sugar binding sites [chemical binding]; other site 1179773012254 Q-X-W motif; other site 1179773012255 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773012256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773012257 S-adenosylmethionine binding site [chemical binding]; other site 1179773012258 Clp protease; Region: CLP_protease; pfam00574 1179773012259 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1179773012260 oligomer interface [polypeptide binding]; other site 1179773012261 active site residues [active] 1179773012262 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1179773012263 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1179773012264 oligomer interface [polypeptide binding]; other site 1179773012265 active site residues [active] 1179773012266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773012267 non-specific DNA binding site [nucleotide binding]; other site 1179773012268 salt bridge; other site 1179773012269 sequence-specific DNA binding site [nucleotide binding]; other site 1179773012270 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1179773012271 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1179773012272 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1179773012273 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1179773012274 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1179773012275 homodimer interface [polypeptide binding]; other site 1179773012276 substrate-cofactor binding pocket; other site 1179773012277 catalytic residue [active] 1179773012278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773012279 motif II; other site 1179773012280 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1179773012281 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1179773012282 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773012283 acyl-activating enzyme (AAE) consensus motif; other site 1179773012284 AMP binding site [chemical binding]; other site 1179773012285 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1179773012286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773012287 substrate binding site [chemical binding]; other site 1179773012288 oxyanion hole (OAH) forming residues; other site 1179773012289 trimer interface [polypeptide binding]; other site 1179773012290 Condensation domain; Region: Condensation; pfam00668 1179773012291 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773012292 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773012293 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773012294 acyl-activating enzyme (AAE) consensus motif; other site 1179773012295 AMP binding site [chemical binding]; other site 1179773012296 active site 1179773012297 CoA binding site [chemical binding]; other site 1179773012298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012299 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773012300 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1179773012301 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773012302 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1179773012303 acyl-activating enzyme (AAE) consensus motif; other site 1179773012304 AMP binding site [chemical binding]; other site 1179773012305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012306 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1179773012307 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773012308 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012309 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012310 active site 1179773012311 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012312 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012314 KR domain; Region: KR; pfam08659 1179773012315 NAD(P) binding site [chemical binding]; other site 1179773012316 active site 1179773012317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012318 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773012319 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773012320 acyl-activating enzyme (AAE) consensus motif; other site 1179773012321 AMP binding site [chemical binding]; other site 1179773012322 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773012323 MbtH-like protein; Region: MbtH; cl01279 1179773012324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773012325 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773012326 Interdomain contacts; other site 1179773012327 Cytokine receptor motif; other site 1179773012328 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773012329 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1179773012330 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1179773012331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773012332 dimerization interface [polypeptide binding]; other site 1179773012333 multicopper oxidase; Provisional; Region: PRK10965 1179773012334 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1179773012335 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1179773012336 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1179773012337 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773012338 DinB superfamily; Region: DinB_2; pfam12867 1179773012339 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773012340 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1179773012341 CHAT domain; Region: CHAT; pfam12770 1179773012342 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773012343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773012344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773012345 DNA binding residues [nucleotide binding] 1179773012346 trehalose synthase; Region: treS_nterm; TIGR02456 1179773012347 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1179773012348 active site 1179773012349 catalytic site [active] 1179773012350 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1179773012351 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773012352 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1179773012353 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1179773012354 catalytic loop [active] 1179773012355 iron binding site [ion binding]; other site 1179773012356 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1179773012357 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1179773012358 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1179773012359 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1179773012360 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1179773012361 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1179773012362 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773012363 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773012364 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773012365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773012366 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773012367 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1179773012368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773012369 S-adenosylmethionine binding site [chemical binding]; other site 1179773012370 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1179773012371 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1179773012372 Leucine-rich repeats; other site 1179773012373 Substrate binding site [chemical binding]; other site 1179773012374 Leucine rich repeat; Region: LRR_8; pfam13855 1179773012375 Leucine rich repeat; Region: LRR_8; pfam13855 1179773012376 Leucine rich repeat; Region: LRR_8; pfam13855 1179773012377 Erythronolide synthase docking; Region: Docking; pfam08990 1179773012378 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012380 active site 1179773012381 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012382 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012383 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012384 putative NADP binding site [chemical binding]; other site 1179773012385 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012386 active site 1179773012387 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012388 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773012389 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1179773012390 putative NAD(P) binding site [chemical binding]; other site 1179773012391 active site 1179773012392 putative substrate binding site [chemical binding]; other site 1179773012393 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012394 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012395 active site 1179773012396 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012397 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012398 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012399 putative NADP binding site [chemical binding]; other site 1179773012400 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773012401 active site 1179773012402 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012403 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012404 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012405 active site 1179773012406 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1179773012407 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012408 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012409 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012410 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012411 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1179773012412 active site 1179773012413 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012414 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012415 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012416 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012417 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012418 active site 1179773012419 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012420 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012421 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012422 putative NADP binding site [chemical binding]; other site 1179773012423 KR domain; Region: KR; pfam08659 1179773012424 active site 1179773012425 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012426 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773012427 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773012428 active site 1179773012429 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773012430 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773012431 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1179773012432 putative NADP binding site [chemical binding]; other site 1179773012433 KR domain; Region: KR; pfam08659 1179773012434 active site 1179773012435 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773012436 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773012437 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1179773012438 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1179773012439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773012440 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1179773012441 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773012442 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773012443 carboxyltransferase (CT) interaction site; other site 1179773012444 biotinylation site [posttranslational modification]; other site 1179773012445 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1179773012446 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1179773012447 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773012448 acyl-CoA synthetase; Validated; Region: PRK05850 1179773012449 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1179773012450 acyl-activating enzyme (AAE) consensus motif; other site 1179773012451 active site 1179773012452 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773012453 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773012454 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773012455 AAA ATPase domain; Region: AAA_16; pfam13191 1179773012456 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773012457 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773012458 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773012459 succinylornithine transaminase family; Region: arg_catab_astC; TIGR03246 1179773012460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773012461 catalytic residue [active] 1179773012462 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773012463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773012464 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773012465 active site 1179773012466 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012467 Cytochrome P450; Region: p450; cl12078 1179773012468 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773012469 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773012470 NAD(P) binding site [chemical binding]; other site 1179773012471 catalytic residues [active] 1179773012472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773012473 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1179773012474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773012475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773012476 active site 1179773012477 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773012478 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1179773012479 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1179773012480 acyl-activating enzyme (AAE) consensus motif; other site 1179773012481 putative AMP binding site [chemical binding]; other site 1179773012482 putative active site [active] 1179773012483 putative CoA binding site [chemical binding]; other site 1179773012484 acyl-CoA synthetase; Validated; Region: PRK06188 1179773012485 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773012486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773012487 acyl-activating enzyme (AAE) consensus motif; other site 1179773012488 AMP binding site [chemical binding]; other site 1179773012489 active site 1179773012490 CoA binding site [chemical binding]; other site 1179773012491 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1179773012492 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1179773012493 substrate-cofactor binding pocket; other site 1179773012494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773012495 catalytic residue [active] 1179773012496 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773012497 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773012498 CHAT domain; Region: CHAT; cl17868 1179773012499 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1179773012500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773012501 TPR motif; other site 1179773012502 binding surface 1179773012503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773012504 binding surface 1179773012505 TPR motif; other site 1179773012506 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773012507 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773012508 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1179773012509 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1179773012510 active site 1179773012511 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1179773012512 Helix-turn-helix domain; Region: HTH_38; pfam13936 1179773012513 MarR family; Region: MarR_2; cl17246 1179773012514 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773012515 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1179773012516 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1179773012517 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1179773012518 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 1179773012519 putative active site [active] 1179773012520 Zn binding site [ion binding]; other site 1179773012521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773012522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773012523 DNA binding residues [nucleotide binding] 1179773012524 dimerization interface [polypeptide binding]; other site 1179773012525 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773012526 active site 1179773012527 metal binding site [ion binding]; metal-binding site 1179773012528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773012529 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773012530 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1179773012531 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1179773012532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1179773012533 PYR/PP interface [polypeptide binding]; other site 1179773012534 dimer interface [polypeptide binding]; other site 1179773012535 TPP binding site [chemical binding]; other site 1179773012536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773012537 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1179773012538 TPP-binding site [chemical binding]; other site 1179773012539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773012540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773012541 DNA binding residues [nucleotide binding] 1179773012542 dimerization interface [polypeptide binding]; other site 1179773012543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773012544 G1 box; other site 1179773012545 GTP/Mg2+ binding site [chemical binding]; other site 1179773012546 G2 box; other site 1179773012547 Switch I region; other site 1179773012548 G3 box; other site 1179773012549 Switch II region; other site 1179773012550 G4 box; other site 1179773012551 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1179773012552 Dynamin family; Region: Dynamin_N; pfam00350 1179773012553 G1 box; other site 1179773012554 GTP/Mg2+ binding site [chemical binding]; other site 1179773012555 G2 box; other site 1179773012556 Switch I region; other site 1179773012557 G3 box; other site 1179773012558 Switch II region; other site 1179773012559 G4 box; other site 1179773012560 G5 box; other site 1179773012561 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773012562 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 1179773012563 nucleotide binding site [chemical binding]; other site 1179773012564 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773012565 SBD interface [polypeptide binding]; other site 1179773012566 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773012567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773012568 non-specific DNA binding site [nucleotide binding]; other site 1179773012569 salt bridge; other site 1179773012570 sequence-specific DNA binding site [nucleotide binding]; other site 1179773012571 NB-ARC domain; Region: NB-ARC; pfam00931 1179773012572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773012573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773012574 TPR motif; other site 1179773012575 binding surface 1179773012576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773012577 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773012578 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773012579 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773012580 HTH domain; Region: HTH_11; pfam08279 1179773012581 WYL domain; Region: WYL; pfam13280 1179773012582 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773012583 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1179773012584 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773012585 active site 1179773012586 catalytic residues [active] 1179773012587 DNA binding site [nucleotide binding] 1179773012588 Int/Topo IB signature motif; other site 1179773012589 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1179773012590 short chain dehydrogenase; Validated; Region: PRK05855 1179773012591 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1179773012592 DNA binding site [nucleotide binding] 1179773012593 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773012594 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1179773012595 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773012596 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773012597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1179773012598 dimerization interface [polypeptide binding]; other site 1179773012599 DNA binding residues [nucleotide binding] 1179773012600 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773012601 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1179773012602 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773012603 DNA binding residues [nucleotide binding] 1179773012604 dimer interface [polypeptide binding]; other site 1179773012605 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773012606 Flagellin N-methylase; Region: FliB; cl00497 1179773012607 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1179773012608 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773012609 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773012610 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1179773012611 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1179773012612 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773012613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773012614 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773012615 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773012616 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773012617 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773012618 homodimer interface [polypeptide binding]; other site 1179773012619 active site 1179773012620 TDP-binding site; other site 1179773012621 acceptor substrate-binding pocket; other site 1179773012622 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1179773012623 active site 1179773012624 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1179773012625 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1179773012626 THF binding site; other site 1179773012627 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1179773012628 substrate binding site [chemical binding]; other site 1179773012629 THF binding site; other site 1179773012630 zinc-binding site [ion binding]; other site 1179773012631 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1179773012632 ATP cone domain; Region: ATP-cone; pfam03477 1179773012633 ATP cone domain; Region: ATP-cone; pfam03477 1179773012634 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1179773012635 active site 1179773012636 dimer interface [polypeptide binding]; other site 1179773012637 catalytic residues [active] 1179773012638 effector binding site; other site 1179773012639 R2 peptide binding site; other site 1179773012640 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1179773012641 dimer interface [polypeptide binding]; other site 1179773012642 putative radical transfer pathway; other site 1179773012643 diiron center [ion binding]; other site 1179773012644 tyrosyl radical; other site 1179773012645 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1179773012646 active site 1179773012647 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1179773012648 dimer interface [polypeptide binding]; other site 1179773012649 non-prolyl cis peptide bond; other site 1179773012650 insertion regions; other site 1179773012651 Cation efflux family; Region: Cation_efflux; cl00316 1179773012652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773012653 dimerization interface [polypeptide binding]; other site 1179773012654 putative DNA binding site [nucleotide binding]; other site 1179773012655 putative Zn2+ binding site [ion binding]; other site 1179773012656 CHASE3 domain; Region: CHASE3; pfam05227 1179773012657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1179773012658 dimerization interface [polypeptide binding]; other site 1179773012659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773012660 dimer interface [polypeptide binding]; other site 1179773012661 phosphorylation site [posttranslational modification] 1179773012662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773012663 ATP binding site [chemical binding]; other site 1179773012664 Mg2+ binding site [ion binding]; other site 1179773012665 G-X-G motif; other site 1179773012666 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773012667 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773012668 ATP binding site [chemical binding]; other site 1179773012669 Mg2+ binding site [ion binding]; other site 1179773012670 G-X-G motif; other site 1179773012671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773012672 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773012673 catalytic site [active] 1179773012674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773012675 PAS domain; Region: PAS_9; pfam13426 1179773012676 putative active site [active] 1179773012677 heme pocket [chemical binding]; other site 1179773012678 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773012679 Response regulator receiver domain; Region: Response_reg; pfam00072 1179773012680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773012681 active site 1179773012682 phosphorylation site [posttranslational modification] 1179773012683 intermolecular recognition site; other site 1179773012684 dimerization interface [polypeptide binding]; other site 1179773012685 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773012686 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773012687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773012688 active site 1179773012689 ATP binding site [chemical binding]; other site 1179773012690 substrate binding site [chemical binding]; other site 1179773012691 activation loop (A-loop); other site 1179773012692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773012693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773012694 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1179773012695 putative effector binding pocket; other site 1179773012696 dimerization interface [polypeptide binding]; other site 1179773012697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012698 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773012699 NAD(P) binding site [chemical binding]; other site 1179773012700 active site 1179773012701 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1179773012702 Catalytic site [active] 1179773012703 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1179773012704 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1179773012705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773012706 Walker A/P-loop; other site 1179773012707 ATP binding site [chemical binding]; other site 1179773012708 Q-loop/lid; other site 1179773012709 ABC transporter signature motif; other site 1179773012710 Walker B; other site 1179773012711 D-loop; other site 1179773012712 H-loop/switch region; other site 1179773012713 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773012714 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773012715 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773012716 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1179773012717 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773012718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773012719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773012720 Walker A motif; other site 1179773012721 ATP binding site [chemical binding]; other site 1179773012722 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1179773012723 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1179773012724 active site 1179773012725 HIGH motif; other site 1179773012726 dimer interface [polypeptide binding]; other site 1179773012727 KMSKS motif; other site 1179773012728 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773012729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012730 NAD(P) binding site [chemical binding]; other site 1179773012731 active site 1179773012732 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773012733 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773012734 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1179773012735 FMN binding site [chemical binding]; other site 1179773012736 active site 1179773012737 substrate binding site [chemical binding]; other site 1179773012738 catalytic residue [active] 1179773012739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773012740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773012741 DNA binding residues [nucleotide binding] 1179773012742 dimerization interface [polypeptide binding]; other site 1179773012743 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1179773012744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1179773012745 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1179773012746 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773012747 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1179773012748 Protein of unknown function (DUF3633); Region: DUF3633; pfam12315 1179773012749 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1179773012750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773012751 metal ion-dependent adhesion site (MIDAS); other site 1179773012752 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1179773012753 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773012754 substrate binding site [chemical binding]; other site 1179773012755 activation loop (A-loop); other site 1179773012756 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1179773012757 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773012758 DinB superfamily; Region: DinB_2; pfam12867 1179773012759 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1179773012760 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1179773012761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773012762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773012763 active site 1179773012764 phosphorylation site [posttranslational modification] 1179773012765 intermolecular recognition site; other site 1179773012766 dimerization interface [polypeptide binding]; other site 1179773012767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773012768 DNA binding site [nucleotide binding] 1179773012769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773012770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773012771 dimerization interface [polypeptide binding]; other site 1179773012772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773012773 dimer interface [polypeptide binding]; other site 1179773012774 phosphorylation site [posttranslational modification] 1179773012775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773012776 ATP binding site [chemical binding]; other site 1179773012777 Mg2+ binding site [ion binding]; other site 1179773012778 G-X-G motif; other site 1179773012779 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1179773012780 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 1179773012781 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773012782 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1179773012783 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1179773012784 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1179773012785 NAD binding site [chemical binding]; other site 1179773012786 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773012787 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773012788 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 1179773012789 putative active site [active] 1179773012790 catalytic site [active] 1179773012791 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1179773012792 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773012793 active site 1179773012794 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1179773012795 Chitinase C; Region: ChiC; pfam06483 1179773012796 Ricin-type beta-trefoil; Region: RICIN; smart00458 1179773012797 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1179773012798 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773012799 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1179773012800 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773012801 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1179773012802 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773012803 substrate binding site [chemical binding]; other site 1179773012804 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1179773012805 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1179773012806 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1179773012807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773012808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773012809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773012810 WHG domain; Region: WHG; pfam13305 1179773012811 active site 1179773012812 metal binding site [ion binding]; metal-binding site 1179773012813 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773012814 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 1179773012815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773012816 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1179773012817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773012818 dimerization interface [polypeptide binding]; other site 1179773012819 putative DNA binding site [nucleotide binding]; other site 1179773012820 putative Zn2+ binding site [ion binding]; other site 1179773012821 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1179773012822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773012823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773012824 Coenzyme A binding pocket [chemical binding]; other site 1179773012825 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1179773012826 PAS fold; Region: PAS_4; pfam08448 1179773012827 GAF domain; Region: GAF; pfam01590 1179773012828 GAF domain; Region: GAF_2; pfam13185 1179773012829 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773012830 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1179773012831 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1179773012832 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1179773012833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773012834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773012835 active site 1179773012836 phosphorylation site [posttranslational modification] 1179773012837 intermolecular recognition site; other site 1179773012838 dimerization interface [polypeptide binding]; other site 1179773012839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773012840 DNA binding residues [nucleotide binding] 1179773012841 dimerization interface [polypeptide binding]; other site 1179773012842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773012843 Histidine kinase; Region: HisKA_3; pfam07730 1179773012844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773012845 ATP binding site [chemical binding]; other site 1179773012846 Mg2+ binding site [ion binding]; other site 1179773012847 G-X-G motif; other site 1179773012848 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1179773012849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773012850 MarR family; Region: MarR_2; pfam12802 1179773012851 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1179773012852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773012853 active site 1179773012854 KMSKS motif; other site 1179773012855 CsbD-like; Region: CsbD; pfam05532 1179773012856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773012857 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773012858 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773012859 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1179773012860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773012861 catalytic residue [active] 1179773012862 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773012863 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1179773012864 acyl-activating enzyme (AAE) consensus motif; other site 1179773012865 putative AMP binding site [chemical binding]; other site 1179773012866 putative active site [active] 1179773012867 putative CoA binding site [chemical binding]; other site 1179773012868 acyl-CoA synthetase; Validated; Region: PRK06188 1179773012869 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773012870 active site 1179773012871 CoA binding site [chemical binding]; other site 1179773012872 AMP binding site [chemical binding]; other site 1179773012873 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012874 Cytochrome P450; Region: p450; cl12078 1179773012875 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1179773012876 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1179773012877 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1179773012878 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1179773012879 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1179773012880 glutamine binding [chemical binding]; other site 1179773012881 catalytic triad [active] 1179773012882 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1179773012883 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1179773012884 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1179773012885 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1179773012886 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1179773012887 UbiA prenyltransferase family; Region: UbiA; pfam01040 1179773012888 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012889 Cytochrome P450; Region: p450; cl12078 1179773012890 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773012891 Cytochrome P450; Region: p450; cl12078 1179773012892 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1179773012893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773012894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773012895 S-adenosylmethionine binding site [chemical binding]; other site 1179773012896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773012897 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773012898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773012899 S-adenosylmethionine binding site [chemical binding]; other site 1179773012900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1179773012901 DNA binding residues [nucleotide binding] 1179773012902 dimerization interface [polypeptide binding]; other site 1179773012903 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773012904 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773012905 Ca2+ binding site [ion binding]; other site 1179773012906 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773012907 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773012908 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773012909 CHAT domain; Region: CHAT; pfam12770 1179773012910 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773012911 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773012912 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773012913 anti sigma factor interaction site; other site 1179773012914 regulatory phosphorylation site [posttranslational modification]; other site 1179773012915 ChaB; Region: ChaB; pfam06150 1179773012916 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1179773012917 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1179773012918 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773012919 NAD binding site [chemical binding]; other site 1179773012920 putative substrate binding site 2 [chemical binding]; other site 1179773012921 putative substrate binding site 1 [chemical binding]; other site 1179773012922 active site 1179773012923 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1179773012924 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1179773012925 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1179773012926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773012927 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1179773012928 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1179773012929 putative active site [active] 1179773012930 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1179773012931 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1179773012932 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1179773012933 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1179773012934 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773012935 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773012936 NAD(P) binding site [chemical binding]; other site 1179773012937 catalytic residues [active] 1179773012938 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1179773012939 classical (c) SDRs; Region: SDR_c; cd05233 1179773012940 NAD(P) binding site [chemical binding]; other site 1179773012941 active site 1179773012942 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773012943 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1179773012944 substrate binding site [chemical binding]; other site 1179773012945 ATP binding site [chemical binding]; other site 1179773012946 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1179773012947 active site 1179773012948 nucleotide binding site [chemical binding]; other site 1179773012949 HIGH motif; other site 1179773012950 KMSKS motif; other site 1179773012951 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1179773012952 dimer interface [polypeptide binding]; other site 1179773012953 active site 1179773012954 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1179773012955 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1179773012956 putative ADP-binding pocket [chemical binding]; other site 1179773012957 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773012958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773012959 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1179773012960 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1179773012961 putative active site [active] 1179773012962 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1179773012963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773012964 active site 1179773012965 motif I; other site 1179773012966 motif II; other site 1179773012967 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1179773012968 short chain dehydrogenase; Provisional; Region: PRK06701 1179773012969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012970 NAD(P) binding site [chemical binding]; other site 1179773012971 active site 1179773012972 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1179773012973 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1179773012974 Probable Catalytic site; other site 1179773012975 metal-binding site 1179773012976 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1179773012977 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1179773012978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773012979 dimer interface [polypeptide binding]; other site 1179773012980 putative PBP binding loops; other site 1179773012981 ABC-ATPase subunit interface; other site 1179773012982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773012983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773012984 dimer interface [polypeptide binding]; other site 1179773012985 conserved gate region; other site 1179773012986 ABC-ATPase subunit interface; other site 1179773012987 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1179773012988 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773012989 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1179773012990 iron-sulfur cluster [ion binding]; other site 1179773012991 [2Fe-2S] cluster binding site [ion binding]; other site 1179773012992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773012993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012994 NAD(P) binding site [chemical binding]; other site 1179773012995 active site 1179773012996 oxidoreductase; Provisional; Region: PRK12743 1179773012997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773012998 NAD(P) binding site [chemical binding]; other site 1179773012999 active site 1179773013000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773013001 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773013002 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773013003 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773013004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773013005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773013006 ANTAR domain; Region: ANTAR; cl04297 1179773013007 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773013008 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1179773013009 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1179773013010 PYR/PP interface [polypeptide binding]; other site 1179773013011 dimer interface [polypeptide binding]; other site 1179773013012 tetramer interface [polypeptide binding]; other site 1179773013013 TPP binding site [chemical binding]; other site 1179773013014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773013015 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1179773013016 TPP-binding site [chemical binding]; other site 1179773013017 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773013018 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773013019 putative sugar binding sites [chemical binding]; other site 1179773013020 Q-X-W motif; other site 1179773013021 phytoene desaturase; Region: crtI_fam; TIGR02734 1179773013022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773013023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773013024 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1179773013025 substrate binding pocket [chemical binding]; other site 1179773013026 chain length determination region; other site 1179773013027 substrate-Mg2+ binding site; other site 1179773013028 catalytic residues [active] 1179773013029 aspartate-rich region 1; other site 1179773013030 active site lid residues [active] 1179773013031 aspartate-rich region 2; other site 1179773013032 Ribosome anti-association factor IF6 binds the large ribosomal subunit and prevents the two subunits from associating during translation initiation. IF6 comprises a family of translation factors that includes both eukaryotic (eIF6) and archeal (aIF6)...; Region: IF6; cl00241 1179773013033 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1179773013034 active site lid residues [active] 1179773013035 substrate binding pocket [chemical binding]; other site 1179773013036 catalytic residues [active] 1179773013037 substrate-Mg2+ binding site; other site 1179773013038 aspartate-rich region 1; other site 1179773013039 aspartate-rich region 2; other site 1179773013040 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1179773013041 [2Fe-2S] cluster binding site [ion binding]; other site 1179773013042 iron-sulfur cluster [ion binding]; other site 1179773013043 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1179773013044 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1179773013045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773013046 S-adenosylmethionine binding site [chemical binding]; other site 1179773013047 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1179773013048 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1179773013049 hydroperoxidase II; Provisional; Region: katE; PRK11249 1179773013050 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1179773013051 heme binding pocket [chemical binding]; other site 1179773013052 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1179773013053 domain interactions; other site 1179773013054 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1179773013055 putative methyltransferase; Provisional; Region: PRK14967 1179773013056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773013057 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1179773013058 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1179773013059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773013060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773013061 catalytic residue [active] 1179773013062 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1179773013063 short chain dehydrogenase; Provisional; Region: PRK07109 1179773013064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773013065 NAD(P) binding site [chemical binding]; other site 1179773013066 active site 1179773013067 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1179773013068 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773013069 NAD binding site [chemical binding]; other site 1179773013070 catalytic Zn binding site [ion binding]; other site 1179773013071 structural Zn binding site [ion binding]; other site 1179773013072 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 1179773013073 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1179773013074 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1179773013075 [4Fe-4S] binding site [ion binding]; other site 1179773013076 molybdopterin cofactor binding site; other site 1179773013077 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1179773013078 molybdopterin cofactor binding site; other site 1179773013079 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773013080 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773013081 anti sigma factor interaction site; other site 1179773013082 regulatory phosphorylation site [posttranslational modification]; other site 1179773013083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773013084 active site 1179773013085 CoA binding site [chemical binding]; other site 1179773013086 AMP binding site [chemical binding]; other site 1179773013087 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773013088 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773013089 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773013090 NAD(P) binding site [chemical binding]; other site 1179773013091 hypothetical protein; Provisional; Region: PRK07236 1179773013092 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773013093 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013094 Cytochrome P450; Region: p450; cl12078 1179773013095 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1179773013096 active site 1179773013097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773013098 classical (c) SDRs; Region: SDR_c; cd05233 1179773013099 NAD(P) binding site [chemical binding]; other site 1179773013100 active site 1179773013101 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1179773013102 active sites [active] 1179773013103 tetramer interface [polypeptide binding]; other site 1179773013104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013105 Cytochrome P450; Region: p450; cl12078 1179773013106 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1179773013107 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1179773013108 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1179773013109 catalytic core [active] 1179773013110 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773013111 Ca2+ binding site [ion binding]; other site 1179773013112 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773013113 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773013114 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773013115 Ca2+ binding site [ion binding]; other site 1179773013116 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1179773013117 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1179773013118 molybdopterin cofactor binding site [chemical binding]; other site 1179773013119 substrate binding site [chemical binding]; other site 1179773013120 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1179773013121 molybdopterin cofactor binding site; other site 1179773013122 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1179773013123 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1179773013124 Cupin domain; Region: Cupin_2; pfam07883 1179773013125 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773013126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773013127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773013128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013129 Walker A/P-loop; other site 1179773013130 ATP binding site [chemical binding]; other site 1179773013131 Q-loop/lid; other site 1179773013132 ABC transporter signature motif; other site 1179773013133 Walker B; other site 1179773013134 D-loop; other site 1179773013135 H-loop/switch region; other site 1179773013136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773013137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773013138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013139 Walker A/P-loop; other site 1179773013140 ATP binding site [chemical binding]; other site 1179773013141 Q-loop/lid; other site 1179773013142 ABC transporter signature motif; other site 1179773013143 Walker B; other site 1179773013144 D-loop; other site 1179773013145 H-loop/switch region; other site 1179773013146 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773013147 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773013148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773013149 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773013150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1179773013151 Condensation domain; Region: Condensation; pfam00668 1179773013152 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773013153 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773013154 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773013155 acyl-activating enzyme (AAE) consensus motif; other site 1179773013156 AMP binding site [chemical binding]; other site 1179773013157 active site 1179773013158 CoA binding site [chemical binding]; other site 1179773013159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773013160 Condensation domain; Region: Condensation; pfam00668 1179773013161 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773013162 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773013163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773013164 acyl-activating enzyme (AAE) consensus motif; other site 1179773013165 AMP binding site [chemical binding]; other site 1179773013166 active site 1179773013167 CoA binding site [chemical binding]; other site 1179773013168 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1179773013169 Condensation domain; Region: Condensation; pfam00668 1179773013170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773013171 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1179773013172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773013173 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1179773013174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773013175 active site 1179773013176 nucleotide binding site [chemical binding]; other site 1179773013177 HIGH motif; other site 1179773013178 KMSKS motif; other site 1179773013179 Cupin domain; Region: Cupin_2; pfam07883 1179773013180 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773013181 FAD dependent oxidoreductase; Region: DAO; pfam01266 1179773013182 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1179773013183 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1179773013184 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1179773013185 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773013186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1179773013187 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1179773013188 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1179773013189 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1179773013190 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1179773013191 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773013192 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773013193 catalytic residue [active] 1179773013194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773013195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773013196 putative substrate translocation pore; other site 1179773013197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773013198 S-adenosylmethionine binding site [chemical binding]; other site 1179773013199 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1179773013200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773013201 dimer interface [polypeptide binding]; other site 1179773013202 putative PBP binding regions; other site 1179773013203 ABC-ATPase subunit interface; other site 1179773013204 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1179773013205 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1179773013206 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773013207 Walker A/P-loop; other site 1179773013208 ATP binding site [chemical binding]; other site 1179773013209 Q-loop/lid; other site 1179773013210 ABC transporter signature motif; other site 1179773013211 Walker B; other site 1179773013212 D-loop; other site 1179773013213 H-loop/switch region; other site 1179773013214 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773013215 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1179773013216 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773013217 intersubunit interface [polypeptide binding]; other site 1179773013218 intersubunit interface [polypeptide binding]; other site 1179773013219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773013220 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773013221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773013222 S-adenosylmethionine binding site [chemical binding]; other site 1179773013223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013224 Cytochrome P450; Region: p450; cl12078 1179773013225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1179773013227 TPR motif; other site 1179773013228 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773013229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773013230 dimerization interface [polypeptide binding]; other site 1179773013231 putative DNA binding site [nucleotide binding]; other site 1179773013232 putative Zn2+ binding site [ion binding]; other site 1179773013233 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773013234 anti sigma factor interaction site; other site 1179773013235 regulatory phosphorylation site [posttranslational modification]; other site 1179773013236 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1179773013237 B12 binding domain; Region: B12-binding_2; pfam02607 1179773013238 B12 binding domain; Region: B12-binding; pfam02310 1179773013239 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1179773013240 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773013241 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1179773013242 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773013243 DNA binding residues [nucleotide binding] 1179773013244 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773013245 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773013246 AAA domain; Region: AAA_22; pfam13401 1179773013247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773013249 TPR motif; other site 1179773013250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013251 binding surface 1179773013252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013253 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773013254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1179773013255 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1179773013256 Chromate transporter; Region: Chromate_transp; pfam02417 1179773013257 Chromate transporter; Region: Chromate_transp; pfam02417 1179773013258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773013259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773013260 putative DNA binding site [nucleotide binding]; other site 1179773013261 dimerization interface [polypeptide binding]; other site 1179773013262 putative Zn2+ binding site [ion binding]; other site 1179773013263 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1179773013264 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1179773013265 active site 1179773013266 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013267 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1179773013268 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013269 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013270 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013271 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013272 RNHCP domain; Region: RNHCP; pfam12647 1179773013273 RNHCP domain; Region: RNHCP; pfam12647 1179773013274 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773013275 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773013276 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1179773013277 DNA binding residues [nucleotide binding] 1179773013278 putative dimer interface [polypeptide binding]; other site 1179773013279 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1179773013280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773013281 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773013282 DNA binding site [nucleotide binding] 1179773013283 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773013284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773013285 TPR motif; other site 1179773013286 binding surface 1179773013287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773013288 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773013289 DNA binding site [nucleotide binding] 1179773013290 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773013291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773013293 DNA binding residues [nucleotide binding] 1179773013294 dimerization interface [polypeptide binding]; other site 1179773013295 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1179773013296 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1179773013297 phage tail protein domain; Region: tail_TIGR02242 1179773013298 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1179773013299 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1179773013300 PAAR motif; Region: PAAR_motif; pfam05488 1179773013301 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1179773013302 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1179773013303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773013304 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1179773013305 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1179773013306 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1179773013307 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1179773013308 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773013309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773013310 Walker A motif; other site 1179773013311 ATP binding site [chemical binding]; other site 1179773013312 Walker B motif; other site 1179773013313 arginine finger; other site 1179773013314 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1179773013315 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1179773013316 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773013317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773013319 DNA binding residues [nucleotide binding] 1179773013320 dimerization interface [polypeptide binding]; other site 1179773013321 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1179773013322 beta-galactosidase; Region: BGL; TIGR03356 1179773013323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1179773013324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013325 dimer interface [polypeptide binding]; other site 1179773013326 conserved gate region; other site 1179773013327 putative PBP binding loops; other site 1179773013328 ABC-ATPase subunit interface; other site 1179773013329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013330 ABC-ATPase subunit interface; other site 1179773013331 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1179773013332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1179773013333 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773013334 DNA binding site [nucleotide binding] 1179773013335 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773013336 AAA ATPase domain; Region: AAA_16; pfam13191 1179773013337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773013339 DNA binding residues [nucleotide binding] 1179773013340 dimerization interface [polypeptide binding]; other site 1179773013341 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1179773013342 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1179773013343 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1179773013344 classical (c) SDRs; Region: SDR_c; cd05233 1179773013345 NAD(P) binding site [chemical binding]; other site 1179773013346 active site 1179773013347 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1179773013348 PA/protease or protease-like domain interface [polypeptide binding]; other site 1179773013349 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1179773013350 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773013351 metal binding site [ion binding]; metal-binding site 1179773013352 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1179773013353 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1179773013354 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773013355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773013356 Walker A/P-loop; other site 1179773013357 ATP binding site [chemical binding]; other site 1179773013358 Q-loop/lid; other site 1179773013359 ABC transporter signature motif; other site 1179773013360 Walker B; other site 1179773013361 D-loop; other site 1179773013362 H-loop/switch region; other site 1179773013363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773013364 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773013365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773013366 Walker A/P-loop; other site 1179773013367 ATP binding site [chemical binding]; other site 1179773013368 Q-loop/lid; other site 1179773013369 ABC transporter signature motif; other site 1179773013370 Walker B; other site 1179773013371 D-loop; other site 1179773013372 H-loop/switch region; other site 1179773013373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773013374 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1179773013375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013376 dimer interface [polypeptide binding]; other site 1179773013377 ABC-ATPase subunit interface; other site 1179773013378 putative PBP binding loops; other site 1179773013379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013381 ABC-ATPase subunit interface; other site 1179773013382 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773013383 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1179773013384 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773013385 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773013386 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773013387 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773013388 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773013389 Carboxylesterase family; Region: COesterase; pfam00135 1179773013390 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773013391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773013392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773013393 DNA binding residues [nucleotide binding] 1179773013394 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773013395 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773013396 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1179773013397 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1179773013398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773013399 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773013400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773013401 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773013402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773013403 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773013404 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773013405 homotrimer interaction site [polypeptide binding]; other site 1179773013406 putative active site [active] 1179773013407 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1179773013408 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1179773013409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773013410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013411 AAA domain; Region: AAA_22; pfam13401 1179773013412 putative sugar binding sites [chemical binding]; other site 1179773013413 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773013414 Q-X-W motif; other site 1179773013415 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773013416 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1179773013417 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773013418 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773013419 substrate binding site [chemical binding]; other site 1179773013420 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1179773013421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773013422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773013423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773013424 Coenzyme A binding pocket [chemical binding]; other site 1179773013425 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1179773013426 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1179773013427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1179773013428 motif II; other site 1179773013429 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1179773013430 metal binding site [ion binding]; metal-binding site 1179773013431 substrate binding site [chemical binding]; other site 1179773013432 hexamer interface [polypeptide binding]; other site 1179773013433 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1179773013434 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773013435 inhibitor-cofactor binding pocket; inhibition site 1179773013436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773013437 catalytic residue [active] 1179773013438 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773013439 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773013440 NAD(P) binding site [chemical binding]; other site 1179773013441 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1179773013442 NAD(P) binding site [chemical binding]; other site 1179773013443 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1179773013444 active site 1179773013445 NAD binding site [chemical binding]; other site 1179773013446 metal binding site [ion binding]; metal-binding site 1179773013447 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773013448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773013449 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1179773013450 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1179773013451 putative active site [active] 1179773013452 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773013453 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1179773013454 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1179773013455 nudix motif; other site 1179773013456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773013457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773013458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773013459 dimerization interface [polypeptide binding]; other site 1179773013460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773013461 NAD(P) binding site [chemical binding]; other site 1179773013462 active site 1179773013463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773013464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773013465 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773013466 putative dimerization interface [polypeptide binding]; other site 1179773013467 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773013468 homotrimer interaction site [polypeptide binding]; other site 1179773013469 putative active site [active] 1179773013470 oxidoreductase; Validated; Region: PRK05717 1179773013471 classical (c) SDRs; Region: SDR_c; cd05233 1179773013472 NAD(P) binding site [chemical binding]; other site 1179773013473 active site 1179773013474 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1179773013475 classical (c) SDRs; Region: SDR_c; cd05233 1179773013476 NAD(P) binding site [chemical binding]; other site 1179773013477 active site 1179773013478 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1179773013479 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1179773013480 active site 1179773013481 Zn binding site [ion binding]; other site 1179773013482 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773013483 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1179773013484 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773013485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013486 dimer interface [polypeptide binding]; other site 1179773013487 conserved gate region; other site 1179773013488 putative PBP binding loops; other site 1179773013489 ABC-ATPase subunit interface; other site 1179773013490 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773013491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773013492 dimer interface [polypeptide binding]; other site 1179773013493 conserved gate region; other site 1179773013494 putative PBP binding loops; other site 1179773013495 ABC-ATPase subunit interface; other site 1179773013496 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773013497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773013498 Walker A/P-loop; other site 1179773013499 ATP binding site [chemical binding]; other site 1179773013500 Q-loop/lid; other site 1179773013501 ABC transporter signature motif; other site 1179773013502 Walker B; other site 1179773013503 D-loop; other site 1179773013504 H-loop/switch region; other site 1179773013505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773013506 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1179773013507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773013508 Walker A/P-loop; other site 1179773013509 ATP binding site [chemical binding]; other site 1179773013510 Q-loop/lid; other site 1179773013511 ABC transporter signature motif; other site 1179773013512 Walker B; other site 1179773013513 D-loop; other site 1179773013514 H-loop/switch region; other site 1179773013515 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1179773013516 aspartate aminotransferase; Provisional; Region: PRK06207 1179773013517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773013518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773013519 homodimer interface [polypeptide binding]; other site 1179773013520 catalytic residue [active] 1179773013521 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1179773013522 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1179773013523 NAD binding site [chemical binding]; other site 1179773013524 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1179773013525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773013526 DNA-binding site [nucleotide binding]; DNA binding site 1179773013527 FCD domain; Region: FCD; pfam07729 1179773013528 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1179773013529 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1179773013530 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773013531 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773013532 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1179773013533 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773013534 NAD binding site [chemical binding]; other site 1179773013535 catalytic Zn binding site [ion binding]; other site 1179773013536 structural Zn binding site [ion binding]; other site 1179773013537 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1179773013538 putative hydrophobic ligand binding site [chemical binding]; other site 1179773013539 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 1179773013540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013541 Walker A/P-loop; other site 1179773013542 ATP binding site [chemical binding]; other site 1179773013543 Q-loop/lid; other site 1179773013544 ABC transporter signature motif; other site 1179773013545 Walker B; other site 1179773013546 D-loop; other site 1179773013547 H-loop/switch region; other site 1179773013548 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 1179773013549 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1179773013550 putative active site [active] 1179773013551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773013552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013553 Walker A/P-loop; other site 1179773013554 ATP binding site [chemical binding]; other site 1179773013555 Q-loop/lid; other site 1179773013556 ABC transporter signature motif; other site 1179773013557 Walker B; other site 1179773013558 D-loop; other site 1179773013559 H-loop/switch region; other site 1179773013560 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1179773013561 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1179773013562 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1179773013563 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773013564 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773013565 acyl-activating enzyme (AAE) consensus motif; other site 1179773013566 AMP binding site [chemical binding]; other site 1179773013567 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773013568 thioester reductase domain; Region: Thioester-redct; TIGR01746 1179773013569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773013570 NAD(P) binding site [chemical binding]; other site 1179773013571 active site 1179773013572 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1179773013573 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773013574 anti sigma factor interaction site; other site 1179773013575 regulatory phosphorylation site [posttranslational modification]; other site 1179773013576 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1179773013577 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773013578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773013579 ATP binding site [chemical binding]; other site 1179773013580 Mg2+ binding site [ion binding]; other site 1179773013581 G-X-G motif; other site 1179773013582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773013583 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773013584 S-adenosylmethionine binding site [chemical binding]; other site 1179773013585 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013586 Cytochrome P450; Region: p450; cl12078 1179773013587 hypothetical protein; Provisional; Region: PRK08201 1179773013588 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773013589 metal binding site [ion binding]; metal-binding site 1179773013590 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773013591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773013592 GAF domain; Region: GAF; pfam01590 1179773013593 ANTAR domain; Region: ANTAR; pfam03861 1179773013594 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773013595 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1179773013596 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1179773013597 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773013598 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1179773013599 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773013600 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1179773013601 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1179773013602 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1179773013603 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1179773013604 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1179773013605 D-pathway; other site 1179773013606 Putative ubiquinol binding site [chemical binding]; other site 1179773013607 Low-spin heme (heme b) binding site [chemical binding]; other site 1179773013608 Putative water exit pathway; other site 1179773013609 Binuclear center (heme o3/CuB) [ion binding]; other site 1179773013610 K-pathway; other site 1179773013611 Putative proton exit pathway; other site 1179773013612 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1179773013613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1179773013614 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1179773013615 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1179773013616 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1179773013617 dimanganese center [ion binding]; other site 1179773013618 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1179773013619 CHAT domain; Region: CHAT; pfam12770 1179773013620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773013621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773013622 dimerization interface [polypeptide binding]; other site 1179773013623 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1179773013624 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1179773013625 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773013626 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1179773013627 NADP binding site [chemical binding]; other site 1179773013628 dimer interface [polypeptide binding]; other site 1179773013629 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773013630 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1179773013631 phosphate binding site [ion binding]; other site 1179773013632 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1179773013633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773013634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773013635 acyl-activating enzyme (AAE) consensus motif; other site 1179773013636 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773013637 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773013638 anti sigma factor interaction site; other site 1179773013639 regulatory phosphorylation site [posttranslational modification]; other site 1179773013640 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1179773013641 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1179773013642 oligomer interface [polypeptide binding]; other site 1179773013643 metal binding site [ion binding]; metal-binding site 1179773013644 metal binding site [ion binding]; metal-binding site 1179773013645 putative Cl binding site [ion binding]; other site 1179773013646 basic sphincter; other site 1179773013647 hydrophobic gate; other site 1179773013648 periplasmic entrance; other site 1179773013649 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773013650 MarR family; Region: MarR; pfam01047 1179773013651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773013652 ATP binding site [chemical binding]; other site 1179773013653 Mg2+ binding site [ion binding]; other site 1179773013654 G-X-G motif; other site 1179773013655 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1179773013656 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1179773013657 CARDB; Region: CARDB; pfam07705 1179773013658 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1179773013659 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773013660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773013661 Walker A/P-loop; other site 1179773013662 ATP binding site [chemical binding]; other site 1179773013663 Q-loop/lid; other site 1179773013664 ABC transporter signature motif; other site 1179773013665 Walker B; other site 1179773013666 D-loop; other site 1179773013667 H-loop/switch region; other site 1179773013668 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773013669 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773013670 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773013671 Walker A/P-loop; other site 1179773013672 ATP binding site [chemical binding]; other site 1179773013673 Q-loop/lid; other site 1179773013674 ABC transporter signature motif; other site 1179773013675 Walker B; other site 1179773013676 D-loop; other site 1179773013677 H-loop/switch region; other site 1179773013678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773013679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773013680 active site 1179773013681 phosphorylation site [posttranslational modification] 1179773013682 intermolecular recognition site; other site 1179773013683 dimerization interface [polypeptide binding]; other site 1179773013684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773013685 DNA binding site [nucleotide binding] 1179773013686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773013687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773013688 dimerization interface [polypeptide binding]; other site 1179773013689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773013690 dimer interface [polypeptide binding]; other site 1179773013691 phosphorylation site [posttranslational modification] 1179773013692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773013693 ATP binding site [chemical binding]; other site 1179773013694 Mg2+ binding site [ion binding]; other site 1179773013695 G-X-G motif; other site 1179773013696 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1179773013697 active site 1179773013698 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1179773013699 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773013700 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773013701 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773013702 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773013703 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773013704 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773013705 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013706 PQQ-like domain; Region: PQQ_2; pfam13360 1179773013707 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013708 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013709 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013710 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773013711 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1179773013712 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1179773013713 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773013714 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773013715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773013716 Walker B motif; other site 1179773013717 arginine finger; other site 1179773013718 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773013719 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773013720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773013721 active site 1179773013722 ATP binding site [chemical binding]; other site 1179773013723 substrate binding site [chemical binding]; other site 1179773013724 activation loop (A-loop); other site 1179773013725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1179773013726 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1179773013727 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773013728 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1179773013729 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773013730 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1179773013731 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773013732 amidase; Provisional; Region: PRK08137 1179773013733 Amidase; Region: Amidase; pfam01425 1179773013734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013735 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1179773013736 Walker A/P-loop; other site 1179773013737 ATP binding site [chemical binding]; other site 1179773013738 Q-loop/lid; other site 1179773013739 ABC transporter signature motif; other site 1179773013740 Walker B; other site 1179773013741 D-loop; other site 1179773013742 H-loop/switch region; other site 1179773013743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773013744 GAF domain; Region: GAF; pfam01590 1179773013745 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773013746 arginine decarboxylase; Provisional; Region: PRK15029 1179773013747 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1179773013748 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773013749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773013750 catalytic residue [active] 1179773013751 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1179773013752 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1179773013753 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1179773013754 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1179773013755 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773013756 active site 1179773013757 catalytic residues [active] 1179773013758 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1179773013759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773013760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773013761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013762 Walker A/P-loop; other site 1179773013763 ATP binding site [chemical binding]; other site 1179773013764 Q-loop/lid; other site 1179773013765 ABC transporter signature motif; other site 1179773013766 Walker B; other site 1179773013767 D-loop; other site 1179773013768 H-loop/switch region; other site 1179773013769 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1179773013770 Ligand Binding Site [chemical binding]; other site 1179773013771 Molecular Tunnel; other site 1179773013772 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1179773013773 MarR family; Region: MarR_2; pfam12802 1179773013774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773013775 hypothetical protein; Provisional; Region: PRK08204 1179773013776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773013777 active site 1179773013778 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773013779 homodimer interface [polypeptide binding]; other site 1179773013780 active site 1179773013781 TDP-binding site; other site 1179773013782 acceptor substrate-binding pocket; other site 1179773013783 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1179773013784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773013785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773013786 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1179773013787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773013788 active site 1179773013789 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1179773013790 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1179773013791 active site 1179773013792 NAD binding site [chemical binding]; other site 1179773013793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1179773013794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013795 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773013796 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773013797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773013798 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773013799 Walker A/P-loop; other site 1179773013800 ATP binding site [chemical binding]; other site 1179773013801 Q-loop/lid; other site 1179773013802 ABC transporter signature motif; other site 1179773013803 Walker B; other site 1179773013804 D-loop; other site 1179773013805 H-loop/switch region; other site 1179773013806 EXLDI protein; Region: EXLDI; TIGR04342 1179773013807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013808 Cytochrome P450; Region: p450; cl12078 1179773013809 SpaB C-terminal domain; Region: SpaB_C; cl14828 1179773013810 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1179773013811 FMN binding site [chemical binding]; other site 1179773013812 dimer interface [polypeptide binding]; other site 1179773013813 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1179773013814 dimer interface [polypeptide binding]; other site 1179773013815 SpaB C-terminal domain; Region: SpaB_C; cl14828 1179773013816 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1179773013817 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1179773013818 FMN binding site [chemical binding]; other site 1179773013819 dimer interface [polypeptide binding]; other site 1179773013820 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1179773013821 YcaO-like family; Region: YcaO; pfam02624 1179773013822 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1179773013823 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1179773013824 EXLDI protein; Region: EXLDI; TIGR04342 1179773013825 Neocarzinostatin family; Region: Neocarzinostat; pfam00960 1179773013826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773013827 HTH domain; Region: HTH_11; pfam08279 1179773013828 WYL domain; Region: WYL; pfam13280 1179773013829 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1179773013830 dimer interface [polypeptide binding]; other site 1179773013831 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773013832 hypothetical protein; Provisional; Region: PRK06834 1179773013833 hypothetical protein; Provisional; Region: PRK07236 1179773013834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773013835 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773013836 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1179773013837 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773013838 MarR family; Region: MarR; pfam01047 1179773013839 hypothetical protein; Provisional; Region: PRK07588 1179773013840 hypothetical protein; Provisional; Region: PRK07236 1179773013841 hypothetical protein; Provisional; Region: PRK07236 1179773013842 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1179773013843 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773013844 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773013845 CAAX protease self-immunity; Region: Abi; pfam02517 1179773013846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773013847 Histidine kinase; Region: HisKA_3; pfam07730 1179773013848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773013850 active site 1179773013851 phosphorylation site [posttranslational modification] 1179773013852 intermolecular recognition site; other site 1179773013853 dimerization interface [polypeptide binding]; other site 1179773013854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773013855 DNA binding residues [nucleotide binding] 1179773013856 dimerization interface [polypeptide binding]; other site 1179773013857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1179773013858 TPR motif; other site 1179773013859 binding surface 1179773013860 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1179773013861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773013862 AAA domain; Region: AAA_22; pfam13401 1179773013863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773013865 TPR motif; other site 1179773013866 binding surface 1179773013867 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773013869 TPR motif; other site 1179773013870 binding surface 1179773013871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773013872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773013873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773013874 DNA binding residues [nucleotide binding] 1179773013875 dimerization interface [polypeptide binding]; other site 1179773013876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773013877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773013878 dimerization interface [polypeptide binding]; other site 1179773013879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773013880 dimer interface [polypeptide binding]; other site 1179773013881 phosphorylation site [posttranslational modification] 1179773013882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773013883 ATP binding site [chemical binding]; other site 1179773013884 Mg2+ binding site [ion binding]; other site 1179773013885 G-X-G motif; other site 1179773013886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773013887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773013888 active site 1179773013889 phosphorylation site [posttranslational modification] 1179773013890 intermolecular recognition site; other site 1179773013891 dimerization interface [polypeptide binding]; other site 1179773013892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773013893 DNA binding site [nucleotide binding] 1179773013894 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773013895 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1179773013896 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773013897 ATP binding site [chemical binding]; other site 1179773013898 ABC transporter; Region: ABC_tran; pfam00005 1179773013899 Q-loop/lid; other site 1179773013900 ABC transporter signature motif; other site 1179773013901 Walker B; other site 1179773013902 D-loop; other site 1179773013903 H-loop/switch region; other site 1179773013904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773013905 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1179773013906 FtsX-like permease family; Region: FtsX; pfam02687 1179773013907 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1179773013908 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1179773013909 putative dimer interface [polypeptide binding]; other site 1179773013910 Domain of unknown function DUF87; Region: DUF87; pfam01935 1179773013911 AAA-like domain; Region: AAA_10; pfam12846 1179773013912 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1179773013913 substrate binding pocket [chemical binding]; other site 1179773013914 substrate-Mg2+ binding site; other site 1179773013915 aspartate-rich region 1; other site 1179773013916 aspartate-rich region 2; other site 1179773013917 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1179773013918 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1179773013919 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1179773013920 Ligand Binding Site [chemical binding]; other site 1179773013921 Molecular Tunnel; other site 1179773013922 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773013923 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773013924 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1179773013925 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773013926 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773013927 Predicted flavoprotein [General function prediction only]; Region: COG0431 1179773013928 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773013929 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773013930 Cytochrome P450; Region: p450; cl12078 1179773013931 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1179773013932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773013933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773013934 catalytic residue [active] 1179773013935 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1179773013936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773013937 S-adenosylmethionine binding site [chemical binding]; other site 1179773013938 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1179773013939 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1179773013940 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1179773013941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773013942 salt bridge; other site 1179773013943 non-specific DNA binding site [nucleotide binding]; other site 1179773013944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773013945 sequence-specific DNA binding site [nucleotide binding]; other site 1179773013946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773013947 putative substrate translocation pore; other site 1179773013948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773013949 active site 1179773013950 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773013951 catalytic tetrad [active] 1179773013952 SnoaL-like domain; Region: SnoaL_4; pfam13577 1179773013953 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1179773013954 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773013955 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1179773013956 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773013957 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773013958 carboxyltransferase (CT) interaction site; other site 1179773013959 biotinylation site [posttranslational modification]; other site 1179773013960 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 1179773013961 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1179773013962 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773013963 dimer interface [polypeptide binding]; other site 1179773013964 active site 1179773013965 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 1179773013966 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1179773013967 active site 1179773013968 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1179773013969 Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945 1179773013970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773013971 NAD(P) binding site [chemical binding]; other site 1179773013972 homodimer interface [polypeptide binding]; other site 1179773013973 substrate binding site [chemical binding]; other site 1179773013974 active site 1179773013975 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 1179773013976 putative hydrophobic ligand binding site [chemical binding]; other site 1179773013977 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 1179773013978 putative hydrophobic ligand binding site [chemical binding]; other site 1179773013979 hypothetical protein; Provisional; Region: PRK06834 1179773013980 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773013981 hypothetical protein; Provisional; Region: PRK08244 1179773013982 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773013983 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1179773013984 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1179773013985 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773013986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773013987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773013988 active site 1179773013989 phosphorylation site [posttranslational modification] 1179773013990 intermolecular recognition site; other site 1179773013991 dimerization interface [polypeptide binding]; other site 1179773013992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773013993 DNA binding site [nucleotide binding] 1179773013994 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1179773013995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773013996 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1179773013997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773013998 putative substrate translocation pore; other site 1179773013999 acyl-CoA synthetase; Validated; Region: PRK05850 1179773014000 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1179773014001 acyl-activating enzyme (AAE) consensus motif; other site 1179773014002 active site 1179773014003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773014004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773014005 active site 1179773014006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773014007 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1179773014008 active site 1179773014009 Thioesterase domain; Region: Thioesterase; pfam00975 1179773014010 Condensation domain; Region: Condensation; pfam00668 1179773014011 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773014012 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1179773014013 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1179773014014 acyl-activating enzyme (AAE) consensus motif; other site 1179773014015 AMP binding site [chemical binding]; other site 1179773014016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014017 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773014018 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773014019 active site 1179773014020 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773014021 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1179773014022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014024 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773014025 NAD(P) binding site [chemical binding]; other site 1179773014026 active site 1179773014027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773014028 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1179773014029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773014030 Cytochrome P450; Region: p450; cl12078 1179773014031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773014032 Cytochrome P450; Region: p450; cl12078 1179773014033 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773014034 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1179773014035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773014036 catalytic residue [active] 1179773014037 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1179773014038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773014039 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1179773014040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773014041 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773014042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773014043 S-adenosylmethionine binding site [chemical binding]; other site 1179773014044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773014045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773014046 non-specific DNA binding site [nucleotide binding]; other site 1179773014047 salt bridge; other site 1179773014048 sequence-specific DNA binding site [nucleotide binding]; other site 1179773014049 Cupin domain; Region: Cupin_2; pfam07883 1179773014050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773014051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773014052 DNA binding residues [nucleotide binding] 1179773014053 dimerization interface [polypeptide binding]; other site 1179773014054 Saf-pilin pilus formation protein; Region: Saf-Nte_pilin; cl09697 1179773014055 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773014056 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773014057 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1179773014058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773014059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773014060 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773014061 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773014062 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1179773014063 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1179773014064 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773014065 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1179773014066 active site 1179773014067 metal binding site [ion binding]; metal-binding site 1179773014068 homotetramer interface [polypeptide binding]; other site 1179773014069 hypothetical protein; Provisional; Region: PRK07588 1179773014070 hypothetical protein; Provisional; Region: PRK07236 1179773014071 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1179773014072 30S subunit binding site; other site 1179773014073 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1179773014074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1179773014075 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773014076 NB-ARC domain; Region: NB-ARC; pfam00931 1179773014077 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014079 TPR motif; other site 1179773014080 binding surface 1179773014081 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1179773014082 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773014083 G1 box; other site 1179773014084 GTP/Mg2+ binding site [chemical binding]; other site 1179773014085 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773014086 G5 box; other site 1179773014087 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1179773014088 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773014089 DNA binding residues [nucleotide binding] 1179773014090 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1179773014091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773014092 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1179773014093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773014094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773014095 active site 1179773014096 metal binding site [ion binding]; metal-binding site 1179773014097 NB-ARC domain; Region: NB-ARC; pfam00931 1179773014098 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014100 TPR motif; other site 1179773014101 binding surface 1179773014102 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014103 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1179773014104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773014105 Walker A/P-loop; other site 1179773014106 ATP binding site [chemical binding]; other site 1179773014107 Q-loop/lid; other site 1179773014108 ABC transporter signature motif; other site 1179773014109 Walker B; other site 1179773014110 D-loop; other site 1179773014111 H-loop/switch region; other site 1179773014112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773014113 short chain dehydrogenase; Provisional; Region: PRK07832 1179773014114 classical (c) SDRs; Region: SDR_c; cd05233 1179773014115 NAD(P) binding site [chemical binding]; other site 1179773014116 active site 1179773014117 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1179773014118 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1179773014119 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1179773014120 active site 1179773014121 catalytic triad [active] 1179773014122 dimer interface [polypeptide binding]; other site 1179773014123 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1179773014124 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773014125 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1179773014126 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773014127 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1179773014128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773014129 Walker A/P-loop; other site 1179773014130 ATP binding site [chemical binding]; other site 1179773014131 Q-loop/lid; other site 1179773014132 ABC transporter signature motif; other site 1179773014133 Walker B; other site 1179773014134 D-loop; other site 1179773014135 H-loop/switch region; other site 1179773014136 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773014137 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773014138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773014139 dimer interface [polypeptide binding]; other site 1179773014140 conserved gate region; other site 1179773014141 putative PBP binding loops; other site 1179773014142 ABC-ATPase subunit interface; other site 1179773014143 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1179773014144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773014145 Walker A/P-loop; other site 1179773014146 ATP binding site [chemical binding]; other site 1179773014147 Q-loop/lid; other site 1179773014148 ABC transporter signature motif; other site 1179773014149 Walker B; other site 1179773014150 D-loop; other site 1179773014151 H-loop/switch region; other site 1179773014152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773014153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773014154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773014155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773014156 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773014157 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1179773014158 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773014159 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1179773014160 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1179773014161 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1179773014162 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773014163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773014164 DNA-binding site [nucleotide binding]; DNA binding site 1179773014165 FCD domain; Region: FCD; pfam07729 1179773014166 classical (c) SDRs; Region: SDR_c; cd05233 1179773014167 NAD(P) binding site [chemical binding]; other site 1179773014168 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773014169 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773014170 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1179773014171 catalytic triad [active] 1179773014172 conserved cis-peptide bond; other site 1179773014173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773014174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773014175 putative substrate translocation pore; other site 1179773014176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773014177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773014178 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1179773014179 dimerization interface [polypeptide binding]; other site 1179773014180 short chain dehydrogenase; Provisional; Region: PRK08263 1179773014181 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1179773014182 NADP binding site [chemical binding]; other site 1179773014183 active site 1179773014184 steroid binding site; other site 1179773014185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773014186 salt bridge; other site 1179773014187 non-specific DNA binding site [nucleotide binding]; other site 1179773014188 sequence-specific DNA binding site [nucleotide binding]; other site 1179773014189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773014190 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773014191 active site 1179773014192 catalytic tetrad [active] 1179773014193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773014194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773014195 WHG domain; Region: WHG; pfam13305 1179773014196 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773014197 RibD C-terminal domain; Region: RibD_C; cl17279 1179773014198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773014199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773014200 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1179773014201 dimerization interface [polypeptide binding]; other site 1179773014202 substrate binding pocket [chemical binding]; other site 1179773014203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1179773014204 MULE transposase domain; Region: MULE; pfam10551 1179773014205 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1179773014206 short chain dehydrogenase; Validated; Region: PRK06182 1179773014207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014208 NAD(P) binding site [chemical binding]; other site 1179773014209 active site 1179773014210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773014211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773014212 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773014213 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1179773014214 catalytic site [active] 1179773014215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773014216 dimerization interface [polypeptide binding]; other site 1179773014217 putative DNA binding site [nucleotide binding]; other site 1179773014218 putative Zn2+ binding site [ion binding]; other site 1179773014219 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1179773014220 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1179773014221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773014222 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773014223 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773014224 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773014225 AAA ATPase domain; Region: AAA_16; pfam13191 1179773014226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773014227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773014228 DNA binding residues [nucleotide binding] 1179773014229 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773014230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773014231 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1179773014232 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773014233 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773014234 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1179773014235 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1179773014236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773014237 ATP binding site [chemical binding]; other site 1179773014238 putative Mg++ binding site [ion binding]; other site 1179773014239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773014240 nucleotide binding region [chemical binding]; other site 1179773014241 ATP-binding site [chemical binding]; other site 1179773014242 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1179773014243 active site 1179773014244 catalytic site [active] 1179773014245 substrate binding site [chemical binding]; other site 1179773014246 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1179773014247 AAA ATPase domain; Region: AAA_16; pfam13191 1179773014248 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 1179773014249 tellurite resistance protein terB; Region: terB; cd07176 1179773014250 putative metal binding site [ion binding]; other site 1179773014251 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1179773014252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773014253 active site 1179773014254 metal binding site [ion binding]; metal-binding site 1179773014255 DNA binding site [nucleotide binding] 1179773014256 AAA domain; Region: AAA_27; pfam13514 1179773014257 Lsr2; Region: Lsr2; pfam11774 1179773014258 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1179773014259 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773014260 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773014261 substrate binding pocket [chemical binding]; other site 1179773014262 membrane-bound complex binding site; other site 1179773014263 hinge residues; other site 1179773014264 Flavin Reductases; Region: FlaRed; cl00801 1179773014265 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773014266 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773014267 NAD(P) binding site [chemical binding]; other site 1179773014268 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1179773014269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014270 Ligand Binding Site [chemical binding]; other site 1179773014271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773014272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773014273 Walker A/P-loop; other site 1179773014274 ATP binding site [chemical binding]; other site 1179773014275 Q-loop/lid; other site 1179773014276 ABC transporter signature motif; other site 1179773014277 Walker B; other site 1179773014278 D-loop; other site 1179773014279 H-loop/switch region; other site 1179773014280 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1179773014281 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773014282 transcriptional regulator NarP; Provisional; Region: PRK10403 1179773014283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773014284 active site 1179773014285 phosphorylation site [posttranslational modification] 1179773014286 intermolecular recognition site; other site 1179773014287 dimerization interface [polypeptide binding]; other site 1179773014288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1179773014289 DNA binding residues [nucleotide binding] 1179773014290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773014291 ATP binding site [chemical binding]; other site 1179773014292 Mg2+ binding site [ion binding]; other site 1179773014293 G-X-G motif; other site 1179773014294 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1179773014295 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1179773014296 ligand binding site [chemical binding]; other site 1179773014297 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014298 Ligand Binding Site [chemical binding]; other site 1179773014299 RES domain; Region: RES; cl02411 1179773014300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014301 Ligand Binding Site [chemical binding]; other site 1179773014302 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014303 Ligand Binding Site [chemical binding]; other site 1179773014304 FOG: CBS domain [General function prediction only]; Region: COG0517 1179773014305 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1179773014306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773014307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773014308 active site 1179773014309 phosphorylation site [posttranslational modification] 1179773014310 intermolecular recognition site; other site 1179773014311 dimerization interface [polypeptide binding]; other site 1179773014312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773014313 DNA binding residues [nucleotide binding] 1179773014314 dimerization interface [polypeptide binding]; other site 1179773014315 Restriction endonuclease NaeI; Region: NaeI; pfam09126 1179773014316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773014317 GAF domain; Region: GAF; pfam01590 1179773014318 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773014319 GAF domain; Region: GAF_3; pfam13492 1179773014320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773014321 Histidine kinase; Region: HisKA_3; pfam07730 1179773014322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773014323 ATP binding site [chemical binding]; other site 1179773014324 Mg2+ binding site [ion binding]; other site 1179773014325 G-X-G motif; other site 1179773014326 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1179773014327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014328 Ligand Binding Site [chemical binding]; other site 1179773014329 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1179773014330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1179773014331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1179773014332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014333 Ligand Binding Site [chemical binding]; other site 1179773014334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773014335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773014336 Coenzyme A binding pocket [chemical binding]; other site 1179773014337 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1179773014338 CoA binding domain; Region: CoA_binding_2; pfam13380 1179773014339 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1179773014340 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1179773014341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014342 Ligand Binding Site [chemical binding]; other site 1179773014343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1179773014344 Ligand Binding Site [chemical binding]; other site 1179773014345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773014346 D-loop; other site 1179773014347 H-loop/switch region; other site 1179773014348 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1179773014349 active site 1179773014350 metal binding site [ion binding]; metal-binding site 1179773014351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773014352 phosphorylation site [posttranslational modification] 1179773014353 intermolecular recognition site; other site 1179773014354 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014355 active site 1179773014356 catalytic residues [active] 1179773014357 DNA binding site [nucleotide binding] 1179773014358 Int/Topo IB signature motif; other site 1179773014359 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1179773014360 active site 1179773014361 zinc binding site [ion binding]; other site 1179773014362 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014363 active site 1179773014364 catalytic residues [active] 1179773014365 DNA binding site [nucleotide binding] 1179773014366 Int/Topo IB signature motif; other site 1179773014367 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014368 DNA binding site [nucleotide binding] 1179773014369 active site 1179773014370 Int/Topo IB signature motif; other site 1179773014371 catalytic residues [active] 1179773014372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773014373 Condensation domain; Region: Condensation; pfam00668 1179773014374 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773014375 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773014376 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773014377 acyl-activating enzyme (AAE) consensus motif; other site 1179773014378 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1179773014379 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773014380 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773014381 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773014382 AMP binding site [chemical binding]; other site 1179773014383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014384 Condensation domain; Region: Condensation; pfam00668 1179773014385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773014386 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773014387 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1179773014388 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1179773014389 active site 1179773014390 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1179773014391 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1179773014392 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1179773014393 putative NADP binding site [chemical binding]; other site 1179773014394 active site 1179773014395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014396 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1179773014397 Condensation domain; Region: Condensation; pfam00668 1179773014398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773014399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773014400 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773014401 acyl-activating enzyme (AAE) consensus motif; other site 1179773014402 AMP binding site [chemical binding]; other site 1179773014403 active site 1179773014404 CoA binding site [chemical binding]; other site 1179773014405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014406 Condensation domain; Region: Condensation; pfam00668 1179773014407 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773014408 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773014409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773014410 acyl-activating enzyme (AAE) consensus motif; other site 1179773014411 AMP binding site [chemical binding]; other site 1179773014412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014413 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1179773014414 active sites [active] 1179773014415 tetramer interface [polypeptide binding]; other site 1179773014416 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1179773014417 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773014418 G1 box; other site 1179773014419 GTP/Mg2+ binding site [chemical binding]; other site 1179773014420 G2 box; other site 1179773014421 Switch I region; other site 1179773014422 G3 box; other site 1179773014423 Switch II region; other site 1179773014424 G4 box; other site 1179773014425 G5 box; other site 1179773014426 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1179773014427 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1179773014428 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1179773014429 ligand-binding site [chemical binding]; other site 1179773014430 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1179773014431 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1179773014432 Active Sites [active] 1179773014433 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773014434 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773014435 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773014436 metal binding site [ion binding]; metal-binding site 1179773014437 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1179773014438 nucleotide binding site [chemical binding]; other site 1179773014439 substrate binding site [chemical binding]; other site 1179773014440 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 1179773014441 acetyl-lysine deacetylase; Provisional; Region: PRK04443 1179773014442 metal binding site [ion binding]; metal-binding site 1179773014443 putative dimer interface [polypeptide binding]; other site 1179773014444 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1179773014445 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1179773014446 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1179773014447 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773014448 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 1179773014449 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1179773014450 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1179773014451 PYR/PP interface [polypeptide binding]; other site 1179773014452 dimer interface [polypeptide binding]; other site 1179773014453 TPP binding site [chemical binding]; other site 1179773014454 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773014455 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1179773014456 TPP-binding site [chemical binding]; other site 1179773014457 dimer interface [polypeptide binding]; other site 1179773014458 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773014459 inhibitor-cofactor binding pocket; inhibition site 1179773014460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773014461 catalytic residue [active] 1179773014462 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773014463 Cytochrome P450; Region: p450; cl12078 1179773014464 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773014465 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1179773014466 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773014467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773014468 active site 1179773014469 Condensation domain; Region: Condensation; pfam00668 1179773014470 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1179773014471 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1179773014472 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1179773014473 acyl-activating enzyme (AAE) consensus motif; other site 1179773014474 AMP binding site [chemical binding]; other site 1179773014475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014476 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1179773014477 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1179773014478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773014479 CoA binding site [chemical binding]; other site 1179773014480 active site 1179773014481 AMP binding site [chemical binding]; other site 1179773014482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1179773014483 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1179773014484 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1179773014485 acyl-activating enzyme (AAE) consensus motif; other site 1179773014486 AMP binding site [chemical binding]; other site 1179773014487 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773014488 active site 1179773014489 putative transposase OrfB; Reviewed; Region: PHA02517 1179773014490 HTH-like domain; Region: HTH_21; pfam13276 1179773014491 Integrase core domain; Region: rve; pfam00665 1179773014492 Integrase core domain; Region: rve_2; pfam13333 1179773014493 Transposase; Region: HTH_Tnp_1; pfam01527 1179773014494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1179773014495 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1179773014496 DDE superfamily endonuclease; Region: DDE_5; cl17874 1179773014497 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1179773014498 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773014499 Integrase core domain; Region: rve; pfam00665 1179773014500 Integrase core domain; Region: rve_3; pfam13683 1179773014501 NACHT domain; Region: NACHT; pfam05729 1179773014502 Transposase; Region: HTH_Tnp_1; pfam01527 1179773014503 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1179773014504 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773014505 structural tetrad; other site 1179773014506 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773014507 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1179773014508 structural tetrad; other site 1179773014509 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1179773014510 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773014511 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773014512 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773014513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773014514 catalytic residue [active] 1179773014515 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1179773014516 putative active site [active] 1179773014517 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1179773014518 catalytic residues [active] 1179773014519 catalytic nucleophile [active] 1179773014520 Recombinase; Region: Recombinase; pfam07508 1179773014521 Integrase core domain; Region: rve; pfam00665 1179773014522 Integrase core domain; Region: rve_3; cl15866 1179773014523 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773014524 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773014525 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773014526 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773014527 Integrase core domain; Region: rve; pfam00665 1179773014528 Integrase core domain; Region: rve_3; pfam13683 1179773014529 putative transposase OrfB; Reviewed; Region: PHA02517 1179773014530 HTH-like domain; Region: HTH_21; pfam13276 1179773014531 Integrase core domain; Region: rve; pfam00665 1179773014532 Integrase core domain; Region: rve_2; pfam13333 1179773014533 Transposase; Region: HTH_Tnp_1; pfam01527 1179773014534 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773014535 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1179773014536 Protein kinase domain; Region: Pkinase; pfam00069 1179773014537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773014538 active site 1179773014539 ATP binding site [chemical binding]; other site 1179773014540 substrate binding site [chemical binding]; other site 1179773014541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773014542 substrate binding site [chemical binding]; other site 1179773014543 activation loop (A-loop); other site 1179773014544 activation loop (A-loop); other site 1179773014545 LabA_like proteins; Region: LabA_like; cd06167 1179773014546 putative metal binding site [ion binding]; other site 1179773014547 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1179773014548 Integrase core domain; Region: rve; pfam00665 1179773014549 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1179773014550 Bacterial TniB protein; Region: TniB; pfam05621 1179773014551 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1179773014552 Helix-turn-helix domain; Region: HTH_38; pfam13936 1179773014553 Integrase core domain; Region: rve; pfam00665 1179773014554 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1179773014555 active site 1179773014556 zinc binding site [ion binding]; other site 1179773014557 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014558 active site 1179773014559 Int/Topo IB signature motif; other site 1179773014560 catalytic residues [active] 1179773014561 DNA binding site [nucleotide binding] 1179773014562 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014563 active site 1179773014564 catalytic residues [active] 1179773014565 DNA binding site [nucleotide binding] 1179773014566 Int/Topo IB signature motif; other site 1179773014567 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014568 active site 1179773014569 catalytic residues [active] 1179773014570 DNA binding site [nucleotide binding] 1179773014571 Int/Topo IB signature motif; other site 1179773014572 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1179773014573 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1179773014574 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014575 active site 1179773014576 catalytic residues [active] 1179773014577 DNA binding site [nucleotide binding] 1179773014578 Int/Topo IB signature motif; other site 1179773014579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014580 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014582 TPR motif; other site 1179773014583 binding surface 1179773014584 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014586 binding surface 1179773014587 TPR motif; other site 1179773014588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773014590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773014591 non-specific DNA binding site [nucleotide binding]; other site 1179773014592 salt bridge; other site 1179773014593 sequence-specific DNA binding site [nucleotide binding]; other site 1179773014594 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1179773014595 Winged helix-turn helix; Region: HTH_29; pfam13551 1179773014596 Homeodomain-like domain; Region: HTH_32; pfam13565 1179773014597 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773014598 Homeodomain-like domain; Region: HTH_23; cl17451 1179773014599 Integrase core domain; Region: rve; pfam00665 1179773014600 Integrase core domain; Region: rve_3; pfam13683 1179773014601 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1179773014602 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773014603 Int/Topo IB signature motif; other site 1179773014604 DNA binding site [nucleotide binding] 1179773014605 active site 1179773014606 Transcription factor WhiB; Region: Whib; pfam02467 1179773014607 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773014608 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1179773014609 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1179773014610 catalytic residues [active] 1179773014611 catalytic nucleophile [active] 1179773014612 Recombinase; Region: Recombinase; pfam07508 1179773014613 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1179773014614 Protein kinase domain; Region: Pkinase; pfam00069 1179773014615 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773014616 active site 1179773014617 ATP binding site [chemical binding]; other site 1179773014618 substrate binding site [chemical binding]; other site 1179773014619 activation loop (A-loop); other site 1179773014620 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1179773014621 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1179773014622 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1179773014623 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773014624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773014625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773014626 dimer interface [polypeptide binding]; other site 1179773014627 phosphorylation site [posttranslational modification] 1179773014628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773014629 ATP binding site [chemical binding]; other site 1179773014630 Mg2+ binding site [ion binding]; other site 1179773014631 G-X-G motif; other site 1179773014632 Response regulator receiver domain; Region: Response_reg; pfam00072 1179773014633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773014634 active site 1179773014635 phosphorylation site [posttranslational modification] 1179773014636 intermolecular recognition site; other site 1179773014637 dimerization interface [polypeptide binding]; other site 1179773014638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773014639 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1179773014640 AAA domain; Region: AAA_22; pfam13401 1179773014641 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1179773014642 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 1179773014643 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1179773014644 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1179773014645 NAD binding site [chemical binding]; other site 1179773014646 substrate binding site [chemical binding]; other site 1179773014647 homodimer interface [polypeptide binding]; other site 1179773014648 active site 1179773014649 hypothetical protein; Provisional; Region: PRK07906 1179773014650 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1179773014651 putative metal binding site [ion binding]; other site 1179773014652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773014653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773014654 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773014655 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773014656 substrate binding site [chemical binding]; other site 1179773014657 OsmC-like protein; Region: OsmC; pfam02566 1179773014658 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1179773014659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773014660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773014661 WHG domain; Region: WHG; pfam13305 1179773014662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014663 binding surface 1179773014664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014665 TPR motif; other site 1179773014666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014667 binding surface 1179773014668 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014669 TPR motif; other site 1179773014670 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014672 binding surface 1179773014673 TPR motif; other site 1179773014674 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014675 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1179773014676 cyanate hydratase; Validated; Region: PRK02866 1179773014677 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1179773014678 oligomer interface [polypeptide binding]; other site 1179773014679 active site 1179773014680 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1179773014681 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773014682 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773014683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773014684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773014685 binding surface 1179773014686 TPR motif; other site 1179773014687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773014688 MarR family; Region: MarR; pfam01047 1179773014689 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1179773014690 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1179773014691 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1179773014692 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773014693 DNA binding residues [nucleotide binding] 1179773014694 putative dimer interface [polypeptide binding]; other site 1179773014695 HEAT repeats; Region: HEAT_2; pfam13646 1179773014696 HEAT repeats; Region: HEAT_2; pfam13646 1179773014697 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773014698 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1179773014699 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1179773014700 potential catalytic triad [active] 1179773014701 conserved cys residue [active] 1179773014702 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1179773014703 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1179773014704 Di-iron ligands [ion binding]; other site 1179773014705 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1179773014706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773014707 non-specific DNA binding site [nucleotide binding]; other site 1179773014708 salt bridge; other site 1179773014709 sequence-specific DNA binding site [nucleotide binding]; other site 1179773014710 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1179773014711 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773014712 active site 1179773014713 metal binding site [ion binding]; metal-binding site 1179773014714 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1179773014715 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773014716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773014717 hypothetical protein; Provisional; Region: PRK01346 1179773014718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1179773014719 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773014720 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773014721 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773014722 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1179773014723 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1179773014724 dimer interface [polypeptide binding]; other site 1179773014725 PYR/PP interface [polypeptide binding]; other site 1179773014726 TPP binding site [chemical binding]; other site 1179773014727 substrate binding site [chemical binding]; other site 1179773014728 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1179773014729 TPP-binding site [chemical binding]; other site 1179773014730 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1179773014731 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1179773014732 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1179773014733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773014734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773014735 dimerization interface [polypeptide binding]; other site 1179773014736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773014737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773014738 DNA-binding site [nucleotide binding]; DNA binding site 1179773014739 UTRA domain; Region: UTRA; pfam07702 1179773014740 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773014741 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773014742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773014743 nucleotide binding site [chemical binding]; other site 1179773014744 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1179773014745 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1179773014746 nucleotide binding site [chemical binding]; other site 1179773014747 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1179773014748 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773014749 active site 1179773014750 metal binding site [ion binding]; metal-binding site 1179773014751 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773014752 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1179773014753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773014754 Walker A/P-loop; other site 1179773014755 ATP binding site [chemical binding]; other site 1179773014756 Q-loop/lid; other site 1179773014757 ABC transporter signature motif; other site 1179773014758 Walker B; other site 1179773014759 D-loop; other site 1179773014760 H-loop/switch region; other site 1179773014761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773014762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773014763 Walker A/P-loop; other site 1179773014764 ATP binding site [chemical binding]; other site 1179773014765 Q-loop/lid; other site 1179773014766 ABC transporter signature motif; other site 1179773014767 Walker B; other site 1179773014768 D-loop; other site 1179773014769 H-loop/switch region; other site 1179773014770 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1179773014771 Sulfatase; Region: Sulfatase; pfam00884 1179773014772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773014773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773014774 dimer interface [polypeptide binding]; other site 1179773014775 conserved gate region; other site 1179773014776 putative PBP binding loops; other site 1179773014777 ABC-ATPase subunit interface; other site 1179773014778 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773014779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773014780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773014781 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1179773014782 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773014783 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773014784 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773014785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773014786 nucleotide binding site [chemical binding]; other site 1179773014787 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1179773014788 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1179773014789 Caspase domain; Region: Peptidase_C14; pfam00656 1179773014790 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773014791 metal ion-dependent adhesion site (MIDAS); other site 1179773014792 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773014793 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773014794 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1179773014795 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773014796 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1179773014797 active site 1179773014798 FMN binding site [chemical binding]; other site 1179773014799 2,4-decadienoyl-CoA binding site; other site 1179773014800 catalytic residue [active] 1179773014801 4Fe-4S cluster binding site [ion binding]; other site 1179773014802 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1179773014803 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1179773014804 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1179773014805 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1179773014806 active site 1179773014807 catalytic triad [active] 1179773014808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773014809 dimerization interface [polypeptide binding]; other site 1179773014810 putative DNA binding site [nucleotide binding]; other site 1179773014811 putative Zn2+ binding site [ion binding]; other site 1179773014812 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1179773014813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773014814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773014815 Coenzyme A binding pocket [chemical binding]; other site 1179773014816 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1179773014817 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773014818 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1179773014819 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1179773014820 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1179773014821 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1179773014822 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1179773014823 substrate binding site; other site 1179773014824 tetramer interface; other site 1179773014825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773014826 CoA binding site [chemical binding]; other site 1179773014827 active site 1179773014828 AMP binding site [chemical binding]; other site 1179773014829 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1179773014830 active sites [active] 1179773014831 tetramer interface [polypeptide binding]; other site 1179773014832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773014833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773014834 S-adenosylmethionine binding site [chemical binding]; other site 1179773014835 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014836 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014837 homodimer interface [polypeptide binding]; other site 1179773014838 active site 1179773014839 TDP-binding site; other site 1179773014840 acceptor substrate-binding pocket; other site 1179773014841 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014842 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014843 homodimer interface [polypeptide binding]; other site 1179773014844 active site 1179773014845 TDP-binding site; other site 1179773014846 acceptor substrate-binding pocket; other site 1179773014847 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014848 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014849 homodimer interface [polypeptide binding]; other site 1179773014850 active site 1179773014851 TDP-binding site; other site 1179773014852 acceptor substrate-binding pocket; other site 1179773014853 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014854 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014855 homodimer interface [polypeptide binding]; other site 1179773014856 active site 1179773014857 TDP-binding site; other site 1179773014858 acceptor substrate-binding pocket; other site 1179773014859 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014860 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014861 homodimer interface [polypeptide binding]; other site 1179773014862 active site 1179773014863 TDP-binding site; other site 1179773014864 acceptor substrate-binding pocket; other site 1179773014865 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014866 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014867 homodimer interface [polypeptide binding]; other site 1179773014868 active site 1179773014869 TDP-binding site; other site 1179773014870 acceptor substrate-binding pocket; other site 1179773014871 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014872 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014873 homodimer interface [polypeptide binding]; other site 1179773014874 active site 1179773014875 TDP-binding site; other site 1179773014876 acceptor substrate-binding pocket; other site 1179773014877 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014878 homodimer interface [polypeptide binding]; other site 1179773014879 active site 1179773014880 TDP-binding site; other site 1179773014881 acceptor substrate-binding pocket; other site 1179773014882 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014883 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014884 homodimer interface [polypeptide binding]; other site 1179773014885 active site 1179773014886 TDP-binding site; other site 1179773014887 acceptor substrate-binding pocket; other site 1179773014888 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773014889 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773014890 homodimer interface [polypeptide binding]; other site 1179773014891 active site 1179773014892 TDP-binding site; other site 1179773014893 acceptor substrate-binding pocket; other site 1179773014894 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1179773014895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014896 NAD(P) binding site [chemical binding]; other site 1179773014897 active site 1179773014898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773014900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773014901 active site 1179773014902 catalytic tetrad [active] 1179773014903 Predicted membrane protein [Function unknown]; Region: COG3428 1179773014904 Bacterial PH domain; Region: DUF304; pfam03703 1179773014905 Bacterial PH domain; Region: DUF304; pfam03703 1179773014906 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1179773014907 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773014908 cysteate synthase; Region: cysteate_syn; TIGR03844 1179773014909 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773014910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773014911 catalytic residue [active] 1179773014912 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773014913 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1179773014914 tetramerization interface [polypeptide binding]; other site 1179773014915 active site 1179773014916 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1179773014917 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1179773014918 inhibitor-cofactor binding pocket; inhibition site 1179773014919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773014920 catalytic residue [active] 1179773014921 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1179773014922 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1179773014923 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1179773014924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773014925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773014926 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1179773014927 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773014928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773014929 S-adenosylmethionine binding site [chemical binding]; other site 1179773014930 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1179773014931 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1179773014932 ligand-binding site [chemical binding]; other site 1179773014933 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1179773014934 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1179773014935 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1179773014936 active site 1179773014937 Predicted membrane protein [Function unknown]; Region: COG2311 1179773014938 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1179773014939 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1179773014940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773014941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773014942 DNA binding residues [nucleotide binding] 1179773014943 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773014944 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1179773014945 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1179773014946 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1179773014947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773014948 Ion channel; Region: Ion_trans_2; pfam07885 1179773014949 hypothetical protein; Provisional; Region: PRK07907 1179773014950 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773014951 metal binding site [ion binding]; metal-binding site 1179773014952 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1179773014953 homodimer interface [polypeptide binding]; other site 1179773014954 homotetramer interface [polypeptide binding]; other site 1179773014955 active site pocket [active] 1179773014956 cleavage site 1179773014957 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1179773014958 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1179773014959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773014960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773014961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773014962 dimerization interface [polypeptide binding]; other site 1179773014963 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1179773014964 short chain dehydrogenase; Provisional; Region: PRK12828 1179773014965 putative NAD(P) binding site [chemical binding]; other site 1179773014966 homodimer interface [polypeptide binding]; other site 1179773014967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773014968 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773014969 non-specific DNA binding site [nucleotide binding]; other site 1179773014970 salt bridge; other site 1179773014971 sequence-specific DNA binding site [nucleotide binding]; other site 1179773014972 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1179773014973 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773014974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773014975 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773014976 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773014977 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1179773014978 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1179773014979 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773014980 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773014981 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1179773014982 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1179773014983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773014984 TspO/MBR family; Region: TspO_MBR; pfam03073 1179773014985 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1179773014986 active site 1179773014987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773014988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773014989 NAD(P) binding site [chemical binding]; other site 1179773014990 active site 1179773014991 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1179773014992 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773014993 TM-ABC transporter signature motif; other site 1179773014994 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1179773014995 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773014996 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1179773014997 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1179773014998 Walker A/P-loop; other site 1179773014999 ATP binding site [chemical binding]; other site 1179773015000 Q-loop/lid; other site 1179773015001 ABC transporter signature motif; other site 1179773015002 Walker B; other site 1179773015003 D-loop; other site 1179773015004 H-loop/switch region; other site 1179773015005 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1179773015006 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1179773015007 substrate binding pocket [chemical binding]; other site 1179773015008 aspartate-rich region 2; other site 1179773015009 substrate-Mg2+ binding site; other site 1179773015010 choline dehydrogenase; Validated; Region: PRK02106 1179773015011 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1179773015012 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1179773015013 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773015014 active site 1179773015015 Domain of unknown function DUF21; Region: DUF21; pfam01595 1179773015016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1179773015017 Domain of unknown function DUF21; Region: DUF21; pfam01595 1179773015018 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1179773015019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1179773015020 Transporter associated domain; Region: CorC_HlyC; smart01091 1179773015021 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773015022 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1179773015023 DNA binding residues [nucleotide binding] 1179773015024 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 1179773015025 putative active site [active] 1179773015026 putative catalytic site [active] 1179773015027 putative Zn binding site [ion binding]; other site 1179773015028 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1179773015029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773015030 putative ADP-binding pocket [chemical binding]; other site 1179773015031 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1179773015032 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1179773015033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773015034 putative ADP-binding pocket [chemical binding]; other site 1179773015035 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773015036 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773015037 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1179773015038 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1179773015039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773015040 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1179773015041 active site 1179773015042 hypothetical protein; Provisional; Region: PRK07233 1179773015043 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1179773015044 active site 1179773015045 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1179773015046 homodimer interface [polypeptide binding]; other site 1179773015047 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1179773015048 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1179773015049 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 1179773015050 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1179773015051 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1179773015052 homodimer interface [polypeptide binding]; other site 1179773015053 NADP binding site [chemical binding]; other site 1179773015054 substrate binding site [chemical binding]; other site 1179773015055 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773015056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773015057 Walker A/P-loop; other site 1179773015058 ATP binding site [chemical binding]; other site 1179773015059 Q-loop/lid; other site 1179773015060 ABC transporter signature motif; other site 1179773015061 Walker B; other site 1179773015062 D-loop; other site 1179773015063 H-loop/switch region; other site 1179773015064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773015065 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1179773015066 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1179773015067 catalytic residue [active] 1179773015068 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773015069 DNA binding site [nucleotide binding] 1179773015070 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773015071 AAA ATPase domain; Region: AAA_16; pfam13191 1179773015072 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773015074 binding surface 1179773015075 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015076 TPR motif; other site 1179773015077 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773015079 binding surface 1179773015080 TPR motif; other site 1179773015081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773015083 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773015084 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015086 active site 1179773015087 phosphorylation site [posttranslational modification] 1179773015088 intermolecular recognition site; other site 1179773015089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015090 DNA binding residues [nucleotide binding] 1179773015091 dimerization interface [polypeptide binding]; other site 1179773015092 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773015093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773015094 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1179773015095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015096 active site 1179773015097 phosphorylation site [posttranslational modification] 1179773015098 intermolecular recognition site; other site 1179773015099 dimerization interface [polypeptide binding]; other site 1179773015100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773015101 DNA binding site [nucleotide binding] 1179773015102 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1179773015103 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1179773015104 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1179773015105 Ligand Binding Site [chemical binding]; other site 1179773015106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773015107 dimer interface [polypeptide binding]; other site 1179773015108 phosphorylation site [posttranslational modification] 1179773015109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773015110 ATP binding site [chemical binding]; other site 1179773015111 Mg2+ binding site [ion binding]; other site 1179773015112 G-X-G motif; other site 1179773015113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773015114 GAF domain; Region: GAF; pfam01590 1179773015115 GAF domain; Region: GAF_2; pfam13185 1179773015116 ANTAR domain; Region: ANTAR; pfam03861 1179773015117 ANTAR domain; Region: ANTAR; cl04297 1179773015118 TIGR03086 family protein; Region: TIGR03086 1179773015119 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1179773015120 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1179773015121 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1179773015122 active site 1179773015123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773015124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773015125 putative substrate translocation pore; other site 1179773015126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773015127 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773015128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015129 putative DNA binding site [nucleotide binding]; other site 1179773015130 putative Zn2+ binding site [ion binding]; other site 1179773015131 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1179773015132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015133 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773015134 Cytochrome P450; Region: p450; cl12078 1179773015135 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1179773015136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015137 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1179773015138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773015139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773015140 putative substrate translocation pore; other site 1179773015141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773015142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015143 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773015144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773015145 S-adenosylmethionine binding site [chemical binding]; other site 1179773015146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773015147 MarR family; Region: MarR; pfam01047 1179773015148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773015149 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1179773015150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1179773015151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1179773015152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1179773015153 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1179773015154 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1179773015155 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1179773015156 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773015157 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773015158 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1179773015159 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1179773015160 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773015161 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773015162 TIR domain; Region: TIR_2; pfam13676 1179773015163 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1179773015164 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1179773015165 dimer interface [polypeptide binding]; other site 1179773015166 active site 1179773015167 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1179773015168 folate binding site [chemical binding]; other site 1179773015169 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1179773015170 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1179773015171 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773015172 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773015173 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773015174 hypothetical protein; Provisional; Region: PRK07236 1179773015175 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1179773015176 VanZ like family; Region: VanZ; cl01971 1179773015177 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773015178 Domain of unknown function DUF11; Region: DUF11; pfam01345 1179773015179 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1179773015180 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773015181 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773015182 Domain of unknown function DUF11; Region: DUF11; cl17728 1179773015183 Domain of unknown function DUF11; Region: DUF11; pfam01345 1179773015184 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1179773015185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773015186 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1179773015187 MarR family; Region: MarR; pfam01047 1179773015188 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1179773015189 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1179773015190 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1179773015191 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773015192 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773015193 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773015194 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773015195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015196 putative DNA binding site [nucleotide binding]; other site 1179773015197 putative Zn2+ binding site [ion binding]; other site 1179773015198 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773015199 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1179773015200 amidohydrolase; Region: amidohydrolases; TIGR01891 1179773015201 metal binding site [ion binding]; metal-binding site 1179773015202 dimer interface [polypeptide binding]; other site 1179773015203 cyclase homology domain; Region: CHD; cd07302 1179773015204 metal binding site [ion binding]; metal-binding site 1179773015205 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773015206 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773015207 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1179773015208 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1179773015209 active site 1179773015210 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1179773015211 amphipathic channel; other site 1179773015212 Asn-Pro-Ala signature motifs; other site 1179773015213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015214 putative DNA binding site [nucleotide binding]; other site 1179773015215 dimerization interface [polypeptide binding]; other site 1179773015216 putative Zn2+ binding site [ion binding]; other site 1179773015217 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1179773015218 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1179773015219 active site 1179773015220 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773015221 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773015222 homodimer interface [polypeptide binding]; other site 1179773015223 active site 1179773015224 TDP-binding site; other site 1179773015225 acceptor substrate-binding pocket; other site 1179773015226 GntP family permease; Region: GntP_permease; pfam02447 1179773015227 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1179773015228 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1179773015229 AAA domain; Region: AAA_33; pfam13671 1179773015230 ATP-binding site [chemical binding]; other site 1179773015231 Gluconate-6-phosphate binding site [chemical binding]; other site 1179773015232 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773015233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773015234 DNA-binding site [nucleotide binding]; DNA binding site 1179773015235 FCD domain; Region: FCD; pfam07729 1179773015236 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773015237 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773015238 homodimer interface [polypeptide binding]; other site 1179773015239 active site 1179773015240 TDP-binding site; other site 1179773015241 acceptor substrate-binding pocket; other site 1179773015242 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773015243 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773015244 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773015245 calcium binding site 2 [ion binding]; other site 1179773015246 active site 1179773015247 catalytic triad [active] 1179773015248 calcium binding site 1 [ion binding]; other site 1179773015249 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773015250 Predicted transcriptional regulators [Transcription]; Region: COG1378 1179773015251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015252 dimerization interface [polypeptide binding]; other site 1179773015253 putative Zn2+ binding site [ion binding]; other site 1179773015254 putative DNA binding site [nucleotide binding]; other site 1179773015255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015257 DNA binding residues [nucleotide binding] 1179773015258 dimerization interface [polypeptide binding]; other site 1179773015259 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773015260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773015261 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1179773015262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773015263 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773015264 Cellulose binding domain; Region: CBM_2; pfam00553 1179773015265 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1179773015266 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1179773015267 putative active site [active] 1179773015268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773015269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773015270 Walker A/P-loop; other site 1179773015271 ATP binding site [chemical binding]; other site 1179773015272 Q-loop/lid; other site 1179773015273 ABC transporter signature motif; other site 1179773015274 Walker B; other site 1179773015275 D-loop; other site 1179773015276 H-loop/switch region; other site 1179773015277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773015278 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773015279 Walker A/P-loop; other site 1179773015280 ATP binding site [chemical binding]; other site 1179773015281 ABC transporter signature motif; other site 1179773015282 Walker B; other site 1179773015283 D-loop; other site 1179773015284 H-loop/switch region; other site 1179773015285 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1179773015286 active site 1179773015287 catalytic triad [active] 1179773015288 oxyanion hole [active] 1179773015289 YcjX-like family, DUF463; Region: DUF463; cl01193 1179773015290 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773015291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773015292 Coenzyme A binding pocket [chemical binding]; other site 1179773015293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773015294 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1179773015295 E3 interaction surface; other site 1179773015296 lipoyl attachment site [posttranslational modification]; other site 1179773015297 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1179773015298 e3 binding domain; Region: E3_binding; pfam02817 1179773015299 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1179773015300 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1179773015301 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1179773015302 alpha subunit interface [polypeptide binding]; other site 1179773015303 TPP binding site [chemical binding]; other site 1179773015304 heterodimer interface [polypeptide binding]; other site 1179773015305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773015306 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1179773015307 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1179773015308 tetramer interface [polypeptide binding]; other site 1179773015309 TPP-binding site [chemical binding]; other site 1179773015310 heterodimer interface [polypeptide binding]; other site 1179773015311 phosphorylation loop region [posttranslational modification] 1179773015312 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773015313 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773015314 putative DNA binding site [nucleotide binding]; other site 1179773015315 putative Zn2+ binding site [ion binding]; other site 1179773015316 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773015317 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1179773015318 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1179773015319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773015320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015321 dimerization interface [polypeptide binding]; other site 1179773015322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773015323 dimer interface [polypeptide binding]; other site 1179773015324 phosphorylation site [posttranslational modification] 1179773015325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773015326 ATP binding site [chemical binding]; other site 1179773015327 Mg2+ binding site [ion binding]; other site 1179773015328 G-X-G motif; other site 1179773015329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773015330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015331 active site 1179773015332 phosphorylation site [posttranslational modification] 1179773015333 intermolecular recognition site; other site 1179773015334 dimerization interface [polypeptide binding]; other site 1179773015335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773015336 DNA binding site [nucleotide binding] 1179773015337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015338 dimerization interface [polypeptide binding]; other site 1179773015339 putative DNA binding site [nucleotide binding]; other site 1179773015340 putative Zn2+ binding site [ion binding]; other site 1179773015341 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1179773015342 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1179773015343 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1179773015344 active site 1179773015345 dimer interface [polypeptide binding]; other site 1179773015346 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1179773015347 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1179773015348 active site 1179773015349 FMN binding site [chemical binding]; other site 1179773015350 substrate binding site [chemical binding]; other site 1179773015351 3Fe-4S cluster binding site [ion binding]; other site 1179773015352 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1179773015353 domain interface; other site 1179773015354 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1179773015355 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773015356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773015357 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1179773015358 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1179773015359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773015360 MarR family; Region: MarR; pfam01047 1179773015361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773015362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773015363 metal binding site [ion binding]; metal-binding site 1179773015364 active site 1179773015365 I-site; other site 1179773015366 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1179773015367 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1179773015368 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773015369 NAD(P) binding site [chemical binding]; other site 1179773015370 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1179773015371 active site 1179773015372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773015373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773015374 ligand binding site [chemical binding]; other site 1179773015375 flexible hinge region; other site 1179773015376 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773015377 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773015378 ligand binding site [chemical binding]; other site 1179773015379 flexible hinge region; other site 1179773015380 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1179773015381 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1179773015382 substrate binding pocket [chemical binding]; other site 1179773015383 chain length determination region; other site 1179773015384 substrate-Mg2+ binding site; other site 1179773015385 catalytic residues [active] 1179773015386 aspartate-rich region 1; other site 1179773015387 active site lid residues [active] 1179773015388 aspartate-rich region 2; other site 1179773015389 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1179773015390 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1179773015391 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1179773015392 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1179773015393 TPP-binding site; other site 1179773015394 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1179773015395 PYR/PP interface [polypeptide binding]; other site 1179773015396 dimer interface [polypeptide binding]; other site 1179773015397 TPP binding site [chemical binding]; other site 1179773015398 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773015399 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1179773015400 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1179773015401 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1179773015402 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773015403 FtsX-like permease family; Region: FtsX; pfam02687 1179773015404 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773015405 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1179773015406 FtsX-like permease family; Region: FtsX; pfam02687 1179773015407 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773015408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773015409 Walker A/P-loop; other site 1179773015410 ATP binding site [chemical binding]; other site 1179773015411 Q-loop/lid; other site 1179773015412 ABC transporter signature motif; other site 1179773015413 Walker B; other site 1179773015414 D-loop; other site 1179773015415 H-loop/switch region; other site 1179773015416 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773015417 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773015418 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1179773015419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773015420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773015421 DNA binding residues [nucleotide binding] 1179773015422 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773015423 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773015424 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1179773015425 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1179773015426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1179773015427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773015428 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1179773015429 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773015430 Peptidase M15; Region: Peptidase_M15_3; pfam08291 1179773015431 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1179773015432 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1179773015433 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773015434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773015435 putative acyl-acceptor binding pocket; other site 1179773015436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1179773015437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015438 active site 1179773015439 phosphorylation site [posttranslational modification] 1179773015440 intermolecular recognition site; other site 1179773015441 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773015442 CHASE3 domain; Region: CHASE3; pfam05227 1179773015443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1179773015444 dimerization interface [polypeptide binding]; other site 1179773015445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773015446 dimer interface [polypeptide binding]; other site 1179773015447 phosphorylation site [posttranslational modification] 1179773015448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773015449 ATP binding site [chemical binding]; other site 1179773015450 Mg2+ binding site [ion binding]; other site 1179773015451 G-X-G motif; other site 1179773015452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015453 Response regulator receiver domain; Region: Response_reg; pfam00072 1179773015454 active site 1179773015455 phosphorylation site [posttranslational modification] 1179773015456 intermolecular recognition site; other site 1179773015457 dimerization interface [polypeptide binding]; other site 1179773015458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773015459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015460 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1179773015461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773015462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773015463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773015464 Coenzyme A binding pocket [chemical binding]; other site 1179773015465 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1179773015466 Part of AAA domain; Region: AAA_19; pfam13245 1179773015467 Family description; Region: UvrD_C_2; pfam13538 1179773015468 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773015469 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773015470 Walker A/P-loop; other site 1179773015471 ATP binding site [chemical binding]; other site 1179773015472 Q-loop/lid; other site 1179773015473 ABC transporter signature motif; other site 1179773015474 Walker B; other site 1179773015475 D-loop; other site 1179773015476 H-loop/switch region; other site 1179773015477 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1179773015478 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1179773015479 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1179773015480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015481 WHG domain; Region: WHG; pfam13305 1179773015482 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1179773015483 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 1179773015484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1179773015485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773015486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773015487 NAD(P) binding site [chemical binding]; other site 1179773015488 active site 1179773015489 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1179773015490 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1179773015491 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773015492 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773015493 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1179773015494 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1179773015495 tetramer interface [polypeptide binding]; other site 1179773015496 active site 1179773015497 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1179773015498 heterodimer interface [polypeptide binding]; other site 1179773015499 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1179773015500 active site 1179773015501 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1179773015502 heterodimer interface [polypeptide binding]; other site 1179773015503 multimer interface [polypeptide binding]; other site 1179773015504 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1179773015505 active site 1179773015506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1179773015508 active site 1179773015509 phosphorylation site [posttranslational modification] 1179773015510 intermolecular recognition site; other site 1179773015511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015512 DNA binding residues [nucleotide binding] 1179773015513 dimerization interface [polypeptide binding]; other site 1179773015514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773015515 PAS domain; Region: PAS_9; pfam13426 1179773015516 putative active site [active] 1179773015517 heme pocket [chemical binding]; other site 1179773015518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773015519 Histidine kinase; Region: HisKA_3; pfam07730 1179773015520 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773015521 Response regulator receiver domain; Region: Response_reg; pfam00072 1179773015522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015523 active site 1179773015524 phosphorylation site [posttranslational modification] 1179773015525 intermolecular recognition site; other site 1179773015526 dimerization interface [polypeptide binding]; other site 1179773015527 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773015528 anti sigma factor interaction site; other site 1179773015529 regulatory phosphorylation site [posttranslational modification]; other site 1179773015530 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773015531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773015532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773015533 non-specific DNA binding site [nucleotide binding]; other site 1179773015534 salt bridge; other site 1179773015535 sequence-specific DNA binding site [nucleotide binding]; other site 1179773015536 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1179773015537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015538 dimerization interface [polypeptide binding]; other site 1179773015539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015540 dimerization interface [polypeptide binding]; other site 1179773015541 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1179773015542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015543 dimerization interface [polypeptide binding]; other site 1179773015544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015545 dimerization interface [polypeptide binding]; other site 1179773015546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015547 dimerization interface [polypeptide binding]; other site 1179773015548 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1179773015549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015550 dimerization interface [polypeptide binding]; other site 1179773015551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015552 dimerization interface [polypeptide binding]; other site 1179773015553 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1179773015554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773015555 dimerization interface [polypeptide binding]; other site 1179773015556 HAMP domain; Region: HAMP; pfam00672 1179773015557 GAF domain; Region: GAF_2; pfam13185 1179773015558 GAF domain; Region: GAF; pfam01590 1179773015559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773015560 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1179773015561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773015562 ATP binding site [chemical binding]; other site 1179773015563 Mg2+ binding site [ion binding]; other site 1179773015564 G-X-G motif; other site 1179773015565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1179773015566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015567 active site 1179773015568 phosphorylation site [posttranslational modification] 1179773015569 intermolecular recognition site; other site 1179773015570 dimerization interface [polypeptide binding]; other site 1179773015571 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1179773015572 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773015573 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773015574 anti sigma factor interaction site; other site 1179773015575 regulatory phosphorylation site [posttranslational modification]; other site 1179773015576 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773015577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773015578 Mg2+ binding site [ion binding]; other site 1179773015579 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773015580 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773015581 active site 1179773015582 substrate binding sites [chemical binding]; other site 1179773015583 CHAT domain; Region: CHAT; pfam12770 1179773015584 Predicted transcriptional regulators [Transcription]; Region: COG1378 1179773015585 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015587 dimerization interface [polypeptide binding]; other site 1179773015588 DNA binding residues [nucleotide binding] 1179773015589 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773015590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1179773015591 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1179773015592 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1179773015593 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773015594 Histidine kinase; Region: HisKA_3; pfam07730 1179773015595 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773015596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015598 active site 1179773015599 phosphorylation site [posttranslational modification] 1179773015600 intermolecular recognition site; other site 1179773015601 dimerization interface [polypeptide binding]; other site 1179773015602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015603 DNA binding residues [nucleotide binding] 1179773015604 dimerization interface [polypeptide binding]; other site 1179773015605 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773015606 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773015607 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773015608 calcium binding site 2 [ion binding]; other site 1179773015609 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773015610 active site 1179773015611 catalytic triad [active] 1179773015612 calcium binding site 1 [ion binding]; other site 1179773015613 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773015614 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773015615 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773015616 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773015617 calcium binding site 2 [ion binding]; other site 1179773015618 active site 1179773015619 catalytic triad [active] 1179773015620 calcium binding site 1 [ion binding]; other site 1179773015621 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773015622 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1179773015623 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1179773015624 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773015625 anti sigma factor interaction site; other site 1179773015626 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773015627 regulatory phosphorylation site [posttranslational modification]; other site 1179773015628 putative acetyltransferase; Provisional; Region: PRK03624 1179773015629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773015630 Coenzyme A binding pocket [chemical binding]; other site 1179773015631 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1179773015632 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773015633 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773015634 ATP binding site [chemical binding]; other site 1179773015635 Mg2+ binding site [ion binding]; other site 1179773015636 G-X-G motif; other site 1179773015637 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773015638 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1179773015639 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773015640 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1179773015641 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773015642 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773015643 active site 1179773015644 ATP binding site [chemical binding]; other site 1179773015645 substrate binding site [chemical binding]; other site 1179773015646 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773015647 substrate binding site [chemical binding]; other site 1179773015648 activation loop (A-loop); other site 1179773015649 activation loop (A-loop); other site 1179773015650 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1179773015651 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1179773015652 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1179773015653 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1179773015654 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1179773015655 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773015656 inhibitor-cofactor binding pocket; inhibition site 1179773015657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773015658 catalytic residue [active] 1179773015659 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773015660 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773015661 NAD(P) binding site [chemical binding]; other site 1179773015662 catalytic residues [active] 1179773015663 cyclase homology domain; Region: CHD; cd07302 1179773015664 nucleotidyl binding site; other site 1179773015665 metal binding site [ion binding]; metal-binding site 1179773015666 dimer interface [polypeptide binding]; other site 1179773015667 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773015668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773015669 Walker A motif; other site 1179773015670 ATP binding site [chemical binding]; other site 1179773015671 Walker B motif; other site 1179773015672 AAA ATPase domain; Region: AAA_16; pfam13191 1179773015673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015674 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015676 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773015677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015679 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773015680 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773015681 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773015682 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1179773015683 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1179773015684 hypothetical protein; Provisional; Region: PRK08317 1179773015685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773015686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773015687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773015688 active site 1179773015689 phosphorylation site [posttranslational modification] 1179773015690 intermolecular recognition site; other site 1179773015691 dimerization interface [polypeptide binding]; other site 1179773015692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773015693 DNA binding site [nucleotide binding] 1179773015694 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1179773015695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773015696 Coenzyme A binding pocket [chemical binding]; other site 1179773015697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773015698 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1179773015699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773015700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773015701 NAD(P) binding site [chemical binding]; other site 1179773015702 active site 1179773015703 ANTAR domain; Region: ANTAR; pfam03861 1179773015704 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1179773015705 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1179773015706 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1179773015707 catalytic site [active] 1179773015708 active site 1179773015709 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1179773015710 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1179773015711 active site 1179773015712 catalytic site [active] 1179773015713 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1179773015714 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1179773015715 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1179773015716 active site 1179773015717 catalytic site [active] 1179773015718 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1179773015719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773015720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773015721 DNA binding site [nucleotide binding] 1179773015722 domain linker motif; other site 1179773015723 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773015724 dimerization interface [polypeptide binding]; other site 1179773015725 ligand binding site [chemical binding]; other site 1179773015726 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1179773015727 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1179773015728 catalytic triad [active] 1179773015729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773015730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015731 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1179773015732 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1179773015733 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1179773015734 Peptidase family M23; Region: Peptidase_M23; pfam01551 1179773015735 Winged helix-turn helix; Region: HTH_29; pfam13551 1179773015736 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773015737 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1179773015738 Transglycosylase; Region: Transgly; pfam00912 1179773015739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1179773015740 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773015741 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1179773015742 substrate binding site [chemical binding]; other site 1179773015743 ATP binding site [chemical binding]; other site 1179773015744 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1179773015745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773015746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773015747 DNA binding residues [nucleotide binding] 1179773015748 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1179773015749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773015750 S-adenosylmethionine binding site [chemical binding]; other site 1179773015751 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1179773015752 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1179773015753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773015754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773015755 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773015756 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1179773015757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773015758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773015759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773015760 DNA binding residues [nucleotide binding] 1179773015761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773015762 dimerization interface [polypeptide binding]; other site 1179773015763 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1179773015764 metal-binding site 1179773015765 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1179773015766 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1179773015767 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1179773015768 hypothetical protein; Provisional; Region: PRK02947 1179773015769 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1179773015770 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1179773015771 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1179773015772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773015773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773015774 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773015775 Walker A/P-loop; other site 1179773015776 ATP binding site [chemical binding]; other site 1179773015777 Q-loop/lid; other site 1179773015778 ABC transporter signature motif; other site 1179773015779 Walker B; other site 1179773015780 D-loop; other site 1179773015781 H-loop/switch region; other site 1179773015782 enoyl-CoA hydratase; Provisional; Region: PRK05870 1179773015783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773015784 substrate binding site [chemical binding]; other site 1179773015785 oxyanion hole (OAH) forming residues; other site 1179773015786 trimer interface [polypeptide binding]; other site 1179773015787 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1179773015788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773015789 Walker A/P-loop; other site 1179773015790 ATP binding site [chemical binding]; other site 1179773015791 Q-loop/lid; other site 1179773015792 ABC transporter signature motif; other site 1179773015793 Walker B; other site 1179773015794 D-loop; other site 1179773015795 H-loop/switch region; other site 1179773015796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1179773015797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773015798 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773015799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773015800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773015801 DNA binding residues [nucleotide binding] 1179773015802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773015803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773015804 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1179773015805 peptide chain release factor 1; Provisional; Region: PRK04011 1179773015806 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1179773015807 putative active site [active] 1179773015808 putative catalytic triad [active] 1179773015809 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1179773015810 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773015811 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 1179773015812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1179773015813 Zn2+ binding site [ion binding]; other site 1179773015814 Mg2+ binding site [ion binding]; other site 1179773015815 MASE1; Region: MASE1; cl17823 1179773015816 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1179773015817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773015818 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1179773015819 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773015820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773015821 metal binding site [ion binding]; metal-binding site 1179773015822 active site 1179773015823 I-site; other site 1179773015824 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773015825 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1179773015826 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1179773015827 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1179773015828 trimerization site [polypeptide binding]; other site 1179773015829 active site 1179773015830 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773015831 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1179773015832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773015833 catalytic residue [active] 1179773015834 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1179773015835 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1179773015836 Walker A/P-loop; other site 1179773015837 ATP binding site [chemical binding]; other site 1179773015838 Q-loop/lid; other site 1179773015839 ABC transporter signature motif; other site 1179773015840 Walker B; other site 1179773015841 D-loop; other site 1179773015842 H-loop/switch region; other site 1179773015843 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1179773015844 [2Fe-2S] cluster binding site [ion binding]; other site 1179773015845 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1179773015846 FeS assembly protein SufD; Region: sufD; TIGR01981 1179773015847 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1179773015848 FeS assembly protein SufB; Region: sufB; TIGR01980 1179773015849 Predicted transcriptional regulator [Transcription]; Region: COG2345 1179773015850 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773015851 putative DNA binding site [nucleotide binding]; other site 1179773015852 putative Zn2+ binding site [ion binding]; other site 1179773015853 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1179773015854 patatin-related protein; Region: TIGR03607 1179773015855 Patatin-like phospholipase; Region: Patatin; pfam01734 1179773015856 nucleophile elbow; other site 1179773015857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773015858 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1179773015859 putative ADP-binding pocket [chemical binding]; other site 1179773015860 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773015861 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773015862 Walker A/P-loop; other site 1179773015863 ATP binding site [chemical binding]; other site 1179773015864 Q-loop/lid; other site 1179773015865 ABC transporter signature motif; other site 1179773015866 Walker B; other site 1179773015867 D-loop; other site 1179773015868 H-loop/switch region; other site 1179773015869 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1179773015870 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1179773015871 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1179773015872 Predicted transcriptional regulators [Transcription]; Region: COG1510 1179773015873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773015874 putative DNA binding site [nucleotide binding]; other site 1179773015875 putative Zn2+ binding site [ion binding]; other site 1179773015876 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1179773015877 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1179773015878 Nitrate and nitrite sensing; Region: NIT; pfam08376 1179773015879 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1179773015880 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1179773015881 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1179773015882 Na binding site [ion binding]; other site 1179773015883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773015884 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1179773015885 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1179773015886 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1179773015887 NADP binding site [chemical binding]; other site 1179773015888 dimer interface [polypeptide binding]; other site 1179773015889 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1179773015890 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1179773015891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773015892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773015893 DNA binding residues [nucleotide binding] 1179773015894 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1179773015895 UbiA prenyltransferase family; Region: UbiA; pfam01040 1179773015896 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1179773015897 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1179773015898 TPP-binding site [chemical binding]; other site 1179773015899 dimer interface [polypeptide binding]; other site 1179773015900 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1179773015901 PYR/PP interface [polypeptide binding]; other site 1179773015902 dimer interface [polypeptide binding]; other site 1179773015903 TPP binding site [chemical binding]; other site 1179773015904 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773015905 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1179773015906 putative active site [active] 1179773015907 transaldolase; Provisional; Region: PRK03903 1179773015908 catalytic residue [active] 1179773015909 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1179773015910 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1179773015911 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1179773015912 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1179773015913 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1179773015914 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1179773015915 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1179773015916 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1179773015917 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1179773015918 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1179773015919 putative active site [active] 1179773015920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773015921 Histidine kinase; Region: HisKA_3; pfam07730 1179773015922 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773015923 ATP binding site [chemical binding]; other site 1179773015924 Mg2+ binding site [ion binding]; other site 1179773015925 G-X-G motif; other site 1179773015926 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1179773015927 triosephosphate isomerase; Provisional; Region: PRK14567 1179773015928 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1179773015929 substrate binding site [chemical binding]; other site 1179773015930 dimer interface [polypeptide binding]; other site 1179773015931 catalytic triad [active] 1179773015932 Phosphoglycerate kinase; Region: PGK; pfam00162 1179773015933 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1179773015934 substrate binding site [chemical binding]; other site 1179773015935 hinge regions; other site 1179773015936 ADP binding site [chemical binding]; other site 1179773015937 catalytic site [active] 1179773015938 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1179773015939 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1179773015940 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1179773015941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1179773015942 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1179773015943 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1179773015944 phosphate binding site [ion binding]; other site 1179773015945 putative substrate binding pocket [chemical binding]; other site 1179773015946 dimer interface [polypeptide binding]; other site 1179773015947 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1179773015948 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1179773015949 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1179773015950 GIY-YIG motif/motif A; other site 1179773015951 active site 1179773015952 catalytic site [active] 1179773015953 putative DNA binding site [nucleotide binding]; other site 1179773015954 metal binding site [ion binding]; metal-binding site 1179773015955 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1179773015956 minor groove reading motif; other site 1179773015957 Helix-hairpin-helix motif; Region: HHH; pfam00633 1179773015958 helix-hairpin-helix signature motif; other site 1179773015959 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 1179773015960 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1179773015961 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1179773015962 iron-sulfur cluster [ion binding]; other site 1179773015963 [2Fe-2S] cluster binding site [ion binding]; other site 1179773015964 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1179773015965 iron-sulfur cluster [ion binding]; other site 1179773015966 [2Fe-2S] cluster binding site [ion binding]; other site 1179773015967 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773015968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773015969 sequence-specific DNA binding site [nucleotide binding]; other site 1179773015970 salt bridge; other site 1179773015971 WYL domain; Region: WYL; pfam13280 1179773015972 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1179773015973 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1179773015974 Peptidase family M28; Region: Peptidase_M28; pfam04389 1179773015975 metal binding site [ion binding]; metal-binding site 1179773015976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773015977 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1179773015978 Walker A motif; other site 1179773015979 ATP binding site [chemical binding]; other site 1179773015980 Walker B motif; other site 1179773015981 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1179773015982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773015983 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1179773015984 Walker A motif; other site 1179773015985 ATP binding site [chemical binding]; other site 1179773015986 Walker B motif; other site 1179773015987 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1179773015988 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1179773015989 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1179773015990 homopentamer interface [polypeptide binding]; other site 1179773015991 active site 1179773015992 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1179773015993 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1179773015994 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1179773015995 dimerization interface [polypeptide binding]; other site 1179773015996 active site 1179773015997 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1179773015998 Lumazine binding domain; Region: Lum_binding; pfam00677 1179773015999 Lumazine binding domain; Region: Lum_binding; pfam00677 1179773016000 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1179773016001 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1179773016002 catalytic motif [active] 1179773016003 Zn binding site [ion binding]; other site 1179773016004 RibD C-terminal domain; Region: RibD_C; cl17279 1179773016005 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1179773016006 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1179773016007 substrate binding site [chemical binding]; other site 1179773016008 hexamer interface [polypeptide binding]; other site 1179773016009 metal binding site [ion binding]; metal-binding site 1179773016010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773016011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773016012 active site 1179773016013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773016014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016016 DNA binding residues [nucleotide binding] 1179773016017 dimerization interface [polypeptide binding]; other site 1179773016018 Flavoprotein; Region: Flavoprotein; cl08021 1179773016019 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1179773016020 putative RNA binding site [nucleotide binding]; other site 1179773016021 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1179773016022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773016023 S-adenosylmethionine binding site [chemical binding]; other site 1179773016024 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1179773016025 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1179773016026 putative active site [active] 1179773016027 substrate binding site [chemical binding]; other site 1179773016028 putative cosubstrate binding site; other site 1179773016029 catalytic site [active] 1179773016030 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1179773016031 substrate binding site [chemical binding]; other site 1179773016032 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1179773016033 active site 1179773016034 catalytic residues [active] 1179773016035 metal binding site [ion binding]; metal-binding site 1179773016036 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1179773016037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016038 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1179773016039 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1179773016040 primosome assembly protein PriA; Provisional; Region: PRK14873 1179773016041 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1179773016042 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1179773016043 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1179773016044 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1179773016045 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1179773016046 Flavoprotein; Region: Flavoprotein; pfam02441 1179773016047 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1179773016048 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1179773016049 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1179773016050 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1179773016051 catalytic site [active] 1179773016052 G-X2-G-X-G-K; other site 1179773016053 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1179773016054 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1179773016055 active site 1179773016056 dimer interface [polypeptide binding]; other site 1179773016057 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1179773016058 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773016059 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1179773016060 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1179773016061 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773016062 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773016063 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1179773016064 IMP binding site; other site 1179773016065 dimer interface [polypeptide binding]; other site 1179773016066 interdomain contacts; other site 1179773016067 partial ornithine binding site; other site 1179773016068 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1179773016069 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1179773016070 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1179773016071 catalytic site [active] 1179773016072 subunit interface [polypeptide binding]; other site 1179773016073 dihydroorotase; Validated; Region: pyrC; PRK09357 1179773016074 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1179773016075 active site 1179773016076 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1179773016077 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1179773016078 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1179773016079 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1179773016080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1179773016081 active site 1179773016082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773016083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773016084 non-specific DNA binding site [nucleotide binding]; other site 1179773016085 salt bridge; other site 1179773016086 sequence-specific DNA binding site [nucleotide binding]; other site 1179773016087 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1179773016088 putative RNA binding site [nucleotide binding]; other site 1179773016089 elongation factor P; Validated; Region: PRK00529 1179773016090 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1179773016091 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1179773016092 RNA binding site [nucleotide binding]; other site 1179773016093 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1179773016094 RNA binding site [nucleotide binding]; other site 1179773016095 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1179773016096 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1179773016097 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1179773016098 active site 1179773016099 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1179773016100 active site 1179773016101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1179773016102 putative dimer interface [polypeptide binding]; other site 1179773016103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773016104 ligand binding site [chemical binding]; other site 1179773016105 Zn binding site [ion binding]; other site 1179773016106 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1179773016107 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1179773016108 trimer interface [polypeptide binding]; other site 1179773016109 active site 1179773016110 dimer interface [polypeptide binding]; other site 1179773016111 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1179773016112 dimer interface [polypeptide binding]; other site 1179773016113 active site 1179773016114 metal binding site [ion binding]; metal-binding site 1179773016115 shikimate kinase; Reviewed; Region: aroK; PRK00131 1179773016116 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1179773016117 ADP binding site [chemical binding]; other site 1179773016118 magnesium binding site [ion binding]; other site 1179773016119 putative shikimate binding site; other site 1179773016120 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1179773016121 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1179773016122 Tetramer interface [polypeptide binding]; other site 1179773016123 active site 1179773016124 FMN-binding site [chemical binding]; other site 1179773016125 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1179773016126 HPr interaction site; other site 1179773016127 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1179773016128 active site 1179773016129 phosphorylation site [posttranslational modification] 1179773016130 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1179773016131 active site turn [active] 1179773016132 phosphorylation site [posttranslational modification] 1179773016133 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773016134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773016135 DNA-binding site [nucleotide binding]; DNA binding site 1179773016136 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1179773016137 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1179773016138 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1179773016139 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1179773016140 dimerization domain swap beta strand [polypeptide binding]; other site 1179773016141 regulatory protein interface [polypeptide binding]; other site 1179773016142 active site 1179773016143 regulatory phosphorylation site [posttranslational modification]; other site 1179773016144 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1179773016145 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1179773016146 shikimate binding site; other site 1179773016147 YceG-like family; Region: YceG; pfam02618 1179773016148 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1179773016149 dimerization interface [polypeptide binding]; other site 1179773016150 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1179773016151 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1179773016152 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1179773016153 motif 1; other site 1179773016154 active site 1179773016155 motif 2; other site 1179773016156 motif 3; other site 1179773016157 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1179773016158 DHHA1 domain; Region: DHHA1; pfam02272 1179773016159 Cupin superfamily protein; Region: Cupin_4; pfam08007 1179773016160 Cupin domain; Region: Cupin_2; cl17218 1179773016161 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773016162 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1179773016163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773016164 S-adenosylmethionine binding site [chemical binding]; other site 1179773016165 recombination factor protein RarA; Reviewed; Region: PRK13342 1179773016166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773016167 Walker A motif; other site 1179773016168 ATP binding site [chemical binding]; other site 1179773016169 Walker B motif; other site 1179773016170 arginine finger; other site 1179773016171 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1179773016172 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1179773016173 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1179773016174 catalytic residue [active] 1179773016175 TIGR02594 family protein; Region: TIGR02594 1179773016176 EspG family; Region: ESX-1_EspG; pfam14011 1179773016177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773016178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773016179 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773016180 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773016181 active site 1179773016182 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1179773016183 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1179773016184 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1179773016185 Walker A/P-loop; other site 1179773016186 ATP binding site [chemical binding]; other site 1179773016187 Q-loop/lid; other site 1179773016188 ABC transporter signature motif; other site 1179773016189 Walker B; other site 1179773016190 D-loop; other site 1179773016191 H-loop/switch region; other site 1179773016192 PDGLE domain; Region: PDGLE; pfam13190 1179773016193 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 1179773016194 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1179773016195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773016196 ATP binding site [chemical binding]; other site 1179773016197 putative Mg++ binding site [ion binding]; other site 1179773016198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773016199 nucleotide binding region [chemical binding]; other site 1179773016200 ATP-binding site [chemical binding]; other site 1179773016201 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1179773016202 DNA binding site [nucleotide binding] 1179773016203 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773016204 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773016205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1179773016206 NB-ARC domain; Region: NB-ARC; pfam00931 1179773016207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773016208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773016209 TPR motif; other site 1179773016210 binding surface 1179773016211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773016212 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1179773016213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773016214 active site 1179773016215 phosphorylation site [posttranslational modification] 1179773016216 intermolecular recognition site; other site 1179773016217 dimerization interface [polypeptide binding]; other site 1179773016218 LytTr DNA-binding domain; Region: LytTR; smart00850 1179773016219 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1179773016220 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1179773016221 Na binding site [ion binding]; other site 1179773016222 GAF domain; Region: GAF_3; pfam13492 1179773016223 Histidine kinase; Region: His_kinase; pfam06580 1179773016224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773016225 ATP binding site [chemical binding]; other site 1179773016226 Mg2+ binding site [ion binding]; other site 1179773016227 G-X-G motif; other site 1179773016228 TIR domain; Region: TIR_2; pfam13676 1179773016229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773016230 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773016231 active site 1179773016232 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1179773016233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773016234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773016235 active site 1179773016236 metal binding site [ion binding]; metal-binding site 1179773016237 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1179773016238 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1179773016239 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1179773016240 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1179773016241 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1179773016242 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1179773016243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773016244 putative substrate translocation pore; other site 1179773016245 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1179773016246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773016247 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773016248 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1179773016249 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1179773016250 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1179773016251 acyl-activating enzyme (AAE) consensus motif; other site 1179773016252 putative AMP binding site [chemical binding]; other site 1179773016253 putative active site [active] 1179773016254 putative CoA binding site [chemical binding]; other site 1179773016255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773016256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773016257 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1179773016258 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1179773016259 active site 1179773016260 metal binding site [ion binding]; metal-binding site 1179773016261 nudix motif; other site 1179773016262 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773016263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773016264 acyl-activating enzyme (AAE) consensus motif; other site 1179773016265 AMP binding site [chemical binding]; other site 1179773016266 active site 1179773016267 CoA binding site [chemical binding]; other site 1179773016268 3-dehydroquinate synthase; Provisional; Region: PRK02290 1179773016269 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1179773016270 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1179773016271 putative active site; other site 1179773016272 catalytic residue [active] 1179773016273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773016274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773016275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773016276 putative dimerization interface [polypeptide binding]; other site 1179773016277 Cupin domain; Region: Cupin_2; pfam07883 1179773016278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773016279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773016280 binding surface 1179773016281 TPR motif; other site 1179773016282 TPR repeat; Region: TPR_11; pfam13414 1179773016283 TPR repeat; Region: TPR_11; pfam13414 1179773016284 TPR repeat; Region: TPR_11; pfam13414 1179773016285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773016286 TPR motif; other site 1179773016287 binding surface 1179773016288 TPR repeat; Region: TPR_11; pfam13414 1179773016289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773016290 NAD(P) binding site [chemical binding]; other site 1179773016291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773016292 active site 1179773016293 AAA ATPase domain; Region: AAA_16; pfam13191 1179773016294 AAA domain; Region: AAA_22; pfam13401 1179773016295 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773016296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773016297 binding surface 1179773016298 TPR motif; other site 1179773016299 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1179773016300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773016301 FeS/SAM binding site; other site 1179773016302 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1179773016303 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1179773016304 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1179773016305 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1179773016306 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1179773016307 RNase_H superfamily; Region: RNase_H_2; pfam13482 1179773016308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773016309 Walker A motif; other site 1179773016310 ATP binding site [chemical binding]; other site 1179773016311 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1179773016312 AAA domain; Region: AAA_12; pfam13087 1179773016313 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1179773016314 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773016315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773016316 substrate binding pocket [chemical binding]; other site 1179773016317 membrane-bound complex binding site; other site 1179773016318 hinge residues; other site 1179773016319 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773016320 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1179773016321 Walker A/P-loop; other site 1179773016322 ATP binding site [chemical binding]; other site 1179773016323 Q-loop/lid; other site 1179773016324 ABC transporter signature motif; other site 1179773016325 Walker B; other site 1179773016326 D-loop; other site 1179773016327 H-loop/switch region; other site 1179773016328 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1179773016329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773016330 dimer interface [polypeptide binding]; other site 1179773016331 conserved gate region; other site 1179773016332 putative PBP binding loops; other site 1179773016333 ABC-ATPase subunit interface; other site 1179773016334 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1179773016335 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773016336 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1179773016337 FMN binding site [chemical binding]; other site 1179773016338 active site 1179773016339 substrate binding site [chemical binding]; other site 1179773016340 catalytic residue [active] 1179773016341 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773016342 MarR family; Region: MarR; pfam01047 1179773016343 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1179773016344 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1179773016345 active site 1179773016346 zinc binding site [ion binding]; other site 1179773016347 AAA ATPase domain; Region: AAA_16; pfam13191 1179773016348 Walker A motif; other site 1179773016349 ATP binding site [chemical binding]; other site 1179773016350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016352 DNA binding residues [nucleotide binding] 1179773016353 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1179773016354 active site 1179773016355 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773016356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1179773016357 MOSC domain; Region: MOSC; pfam03473 1179773016358 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773016359 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773016360 active site 1179773016361 catalytic tetrad [active] 1179773016362 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1179773016363 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1179773016364 substrate binding site [chemical binding]; other site 1179773016365 dimer interface [polypeptide binding]; other site 1179773016366 NADP binding site [chemical binding]; other site 1179773016367 catalytic residues [active] 1179773016368 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773016369 active site 2 [active] 1179773016370 active site 1 [active] 1179773016371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773016372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773016373 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773016374 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1179773016375 PAC2 family; Region: PAC2; pfam09754 1179773016376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773016377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773016378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773016379 Walker A/P-loop; other site 1179773016380 ATP binding site [chemical binding]; other site 1179773016381 Q-loop/lid; other site 1179773016382 ABC transporter signature motif; other site 1179773016383 Walker B; other site 1179773016384 D-loop; other site 1179773016385 H-loop/switch region; other site 1179773016386 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1179773016387 putative hydrophobic ligand binding site [chemical binding]; other site 1179773016388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773016389 putative DNA binding site [nucleotide binding]; other site 1179773016390 putative Zn2+ binding site [ion binding]; other site 1179773016391 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1179773016392 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1179773016393 metal binding site [ion binding]; metal-binding site 1179773016394 dimer interface [polypeptide binding]; other site 1179773016395 AMP-binding domain protein; Validated; Region: PRK08315 1179773016396 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1179773016397 acyl-activating enzyme (AAE) consensus motif; other site 1179773016398 putative AMP binding site [chemical binding]; other site 1179773016399 putative active site [active] 1179773016400 putative CoA binding site [chemical binding]; other site 1179773016401 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1179773016402 RNAase interaction site [polypeptide binding]; other site 1179773016403 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773016404 Cytokine receptor motif; other site 1179773016405 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773016406 Interdomain contacts; other site 1179773016407 Cytokine receptor motif; other site 1179773016408 adenylosuccinate lyase; Reviewed; Region: PRK08540 1179773016409 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1179773016410 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1179773016411 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1179773016412 probable active site [active] 1179773016413 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1179773016414 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1179773016415 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1179773016416 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773016417 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773016418 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1179773016419 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773016420 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1179773016421 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773016422 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1179773016423 putative sugar binding site [chemical binding]; other site 1179773016424 catalytic residues [active] 1179773016425 GrpE; Region: GrpE; pfam01025 1179773016426 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773016427 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773016428 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773016429 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773016430 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1179773016431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773016432 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1179773016433 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773016434 putative NAD(P) binding site [chemical binding]; other site 1179773016435 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1179773016436 classical (c) SDRs; Region: SDR_c; cd05233 1179773016437 NAD(P) binding site [chemical binding]; other site 1179773016438 active site 1179773016439 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1179773016440 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1179773016441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773016442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773016443 DNA binding site [nucleotide binding] 1179773016444 domain linker motif; other site 1179773016445 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773016446 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773016447 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1179773016448 Domain of unknown function DUF21; Region: DUF21; pfam01595 1179773016449 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1179773016450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1179773016451 Transporter associated domain; Region: CorC_HlyC; smart01091 1179773016452 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1179773016453 Domain of unknown function DUF21; Region: DUF21; pfam01595 1179773016454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1179773016455 HicB family; Region: HicB; pfam05534 1179773016456 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1179773016457 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773016458 Cytochrome P450; Region: p450; cl12078 1179773016459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773016460 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773016461 Walker A/P-loop; other site 1179773016462 ATP binding site [chemical binding]; other site 1179773016463 Q-loop/lid; other site 1179773016464 ABC transporter signature motif; other site 1179773016465 Walker B; other site 1179773016466 D-loop; other site 1179773016467 H-loop/switch region; other site 1179773016468 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1179773016469 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773016470 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773016471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773016472 putative DNA binding site [nucleotide binding]; other site 1179773016473 putative Zn2+ binding site [ion binding]; other site 1179773016474 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1179773016475 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1179773016476 metal ion-dependent adhesion site (MIDAS); other site 1179773016477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773016478 putative DNA binding site [nucleotide binding]; other site 1179773016479 dimerization interface [polypeptide binding]; other site 1179773016480 putative Zn2+ binding site [ion binding]; other site 1179773016481 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773016482 classical (c) SDRs; Region: SDR_c; cd05233 1179773016483 NAD(P) binding site [chemical binding]; other site 1179773016484 active site 1179773016485 glycine dehydrogenase; Provisional; Region: PRK05367 1179773016486 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1179773016487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773016488 tetramer interface [polypeptide binding]; other site 1179773016489 catalytic residue [active] 1179773016490 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1179773016491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773016492 catalytic residue [active] 1179773016493 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1179773016494 DNA binding residues [nucleotide binding] 1179773016495 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773016496 putative dimer interface [polypeptide binding]; other site 1179773016497 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1179773016498 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1179773016499 DNA binding residues [nucleotide binding] 1179773016500 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773016501 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1179773016502 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1179773016503 phosphopeptide binding site; other site 1179773016504 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1179773016505 lipoyl attachment site [posttranslational modification]; other site 1179773016506 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1179773016507 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773016508 anti sigma factor interaction site; other site 1179773016509 regulatory phosphorylation site [posttranslational modification]; other site 1179773016510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1179773016511 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773016512 Mg2+ binding site [ion binding]; other site 1179773016513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1179773016514 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773016515 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1179773016516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016517 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1179773016518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773016519 DNA binding residues [nucleotide binding] 1179773016520 Transcription factor WhiB; Region: Whib; pfam02467 1179773016521 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1179773016522 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773016523 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773016524 active site 1179773016525 catalytic tetrad [active] 1179773016526 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1179773016527 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1179773016528 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773016529 putative NAD(P) binding site [chemical binding]; other site 1179773016530 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773016531 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1179773016532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773016534 DNA binding residues [nucleotide binding] 1179773016535 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1179773016536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773016537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773016538 DNA binding site [nucleotide binding] 1179773016539 domain linker motif; other site 1179773016540 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773016541 dimerization interface [polypeptide binding]; other site 1179773016542 ligand binding site [chemical binding]; other site 1179773016543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773016544 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1179773016545 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773016546 putative NAD(P) binding site [chemical binding]; other site 1179773016547 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1179773016548 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1179773016549 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1179773016550 nucleotidyl binding site; other site 1179773016551 metal binding site [ion binding]; metal-binding site 1179773016552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773016553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773016554 hypothetical protein; Provisional; Region: PRK07945 1179773016555 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1179773016556 active site 1179773016557 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1179773016558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773016559 FeS/SAM binding site; other site 1179773016560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773016561 Histidine kinase; Region: HisKA_3; pfam07730 1179773016562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773016563 ATP binding site [chemical binding]; other site 1179773016564 Mg2+ binding site [ion binding]; other site 1179773016565 G-X-G motif; other site 1179773016566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773016568 active site 1179773016569 phosphorylation site [posttranslational modification] 1179773016570 intermolecular recognition site; other site 1179773016571 dimerization interface [polypeptide binding]; other site 1179773016572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016573 DNA binding residues [nucleotide binding] 1179773016574 dimerization interface [polypeptide binding]; other site 1179773016575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016577 DNA binding residues [nucleotide binding] 1179773016578 dimerization interface [polypeptide binding]; other site 1179773016579 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1179773016580 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1179773016581 metal ion-dependent adhesion site (MIDAS); other site 1179773016582 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1179773016583 phage tail protein domain; Region: tail_TIGR02242 1179773016584 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1179773016585 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1179773016586 PAAR motif; Region: PAAR_motif; cl15808 1179773016587 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1179773016588 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1179773016589 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1179773016590 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1179773016591 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1179773016592 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1179773016593 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1179773016594 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1179773016595 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1179773016596 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773016597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773016598 ATP binding site [chemical binding]; other site 1179773016599 Walker A motif; other site 1179773016600 Walker B motif; other site 1179773016601 arginine finger; other site 1179773016602 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1179773016603 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1179773016604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773016605 non-specific DNA binding site [nucleotide binding]; other site 1179773016606 salt bridge; other site 1179773016607 sequence-specific DNA binding site [nucleotide binding]; other site 1179773016608 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773016609 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1179773016610 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1179773016611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016612 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1179773016613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773016614 DNA binding residues [nucleotide binding] 1179773016615 eRF1 domain 3; Region: eRF1_3; pfam03465 1179773016616 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1179773016617 anti sigma factor interaction site; other site 1179773016618 regulatory phosphorylation site [posttranslational modification]; other site 1179773016619 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773016620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016621 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1179773016622 nucleoside/Zn binding site; other site 1179773016623 catalytic motif [active] 1179773016624 dimer interface [polypeptide binding]; other site 1179773016625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773016626 Coenzyme A binding pocket [chemical binding]; other site 1179773016627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773016628 TPR motif; other site 1179773016629 binding surface 1179773016630 CHAT domain; Region: CHAT; cl17868 1179773016631 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773016632 active site 1179773016633 catalytic residues [active] 1179773016634 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773016635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773016636 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773016637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773016638 S-adenosylmethionine binding site [chemical binding]; other site 1179773016639 PAS domain; Region: PAS_9; pfam13426 1179773016640 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1179773016641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773016642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773016643 metal binding site [ion binding]; metal-binding site 1179773016644 active site 1179773016645 I-site; other site 1179773016646 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773016647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773016648 S-adenosylmethionine binding site [chemical binding]; other site 1179773016649 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1179773016650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1179773016651 G2 box; other site 1179773016652 Switch I region; other site 1179773016653 G3 box; other site 1179773016654 Switch II region; other site 1179773016655 GTP/Mg2+ binding site [chemical binding]; other site 1179773016656 G4 box; other site 1179773016657 G5 box; other site 1179773016658 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1179773016659 Nitrate and nitrite sensing; Region: NIT; pfam08376 1179773016660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773016661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773016662 ATP binding site [chemical binding]; other site 1179773016663 Mg2+ binding site [ion binding]; other site 1179773016664 G-X-G motif; other site 1179773016665 NMT1/THI5 like; Region: NMT1; pfam09084 1179773016666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773016667 substrate binding pocket [chemical binding]; other site 1179773016668 membrane-bound complex binding site; other site 1179773016669 hinge residues; other site 1179773016670 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1179773016671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773016672 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773016673 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1179773016674 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773016675 Walker A/P-loop; other site 1179773016676 ATP binding site [chemical binding]; other site 1179773016677 Q-loop/lid; other site 1179773016678 ABC transporter signature motif; other site 1179773016679 Walker B; other site 1179773016680 D-loop; other site 1179773016681 H-loop/switch region; other site 1179773016682 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773016683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773016684 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773016685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773016686 dimer interface [polypeptide binding]; other site 1179773016687 conserved gate region; other site 1179773016688 ABC-ATPase subunit interface; other site 1179773016689 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773016690 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773016691 structural tetrad; other site 1179773016692 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773016693 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1179773016694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773016695 RNA binding surface [nucleotide binding]; other site 1179773016696 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1179773016697 active site 1179773016698 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1179773016699 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1179773016700 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1179773016701 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773016702 P-loop; other site 1179773016703 Magnesium ion binding site [ion binding]; other site 1179773016704 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773016705 Magnesium ion binding site [ion binding]; other site 1179773016706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773016707 dimerization interface [polypeptide binding]; other site 1179773016708 putative DNA binding site [nucleotide binding]; other site 1179773016709 putative Zn2+ binding site [ion binding]; other site 1179773016710 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1179773016711 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773016712 active site 1179773016713 DNA binding site [nucleotide binding] 1179773016714 Int/Topo IB signature motif; other site 1179773016715 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1179773016716 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1179773016717 hexamer interface [polypeptide binding]; other site 1179773016718 ligand binding site [chemical binding]; other site 1179773016719 putative active site [active] 1179773016720 NAD(P) binding site [chemical binding]; other site 1179773016721 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773016722 TM2 domain; Region: TM2; pfam05154 1179773016723 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1179773016724 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1179773016725 dimer interface [polypeptide binding]; other site 1179773016726 active site 1179773016727 ADP-ribose binding site [chemical binding]; other site 1179773016728 nudix motif; other site 1179773016729 metal binding site [ion binding]; metal-binding site 1179773016730 CTP synthetase; Validated; Region: pyrG; PRK05380 1179773016731 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1179773016732 Catalytic site [active] 1179773016733 active site 1179773016734 UTP binding site [chemical binding]; other site 1179773016735 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1179773016736 active site 1179773016737 putative oxyanion hole; other site 1179773016738 catalytic triad [active] 1179773016739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773016740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773016741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773016742 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1179773016743 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1179773016744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773016745 Walker A/P-loop; other site 1179773016746 ATP binding site [chemical binding]; other site 1179773016747 Q-loop/lid; other site 1179773016748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773016749 ABC transporter signature motif; other site 1179773016750 Walker B; other site 1179773016751 D-loop; other site 1179773016752 H-loop/switch region; other site 1179773016753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773016754 Walker A/P-loop; other site 1179773016755 ATP binding site [chemical binding]; other site 1179773016756 Q-loop/lid; other site 1179773016757 ABC transporter signature motif; other site 1179773016758 Walker B; other site 1179773016759 D-loop; other site 1179773016760 H-loop/switch region; other site 1179773016761 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1179773016762 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1179773016763 Thiamine pyrophosphokinase; Region: TPK; cl08415 1179773016764 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1179773016765 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1179773016766 Walker A/P-loop; other site 1179773016767 ATP binding site [chemical binding]; other site 1179773016768 Q-loop/lid; other site 1179773016769 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1179773016770 ABC transporter signature motif; other site 1179773016771 Walker B; other site 1179773016772 D-loop; other site 1179773016773 H-loop/switch region; other site 1179773016774 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1179773016775 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1179773016776 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1179773016777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773016778 RNA binding surface [nucleotide binding]; other site 1179773016779 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1179773016780 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1179773016781 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1179773016782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773016783 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1179773016784 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1179773016785 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1179773016786 active site 1179773016787 HIGH motif; other site 1179773016788 dimer interface [polypeptide binding]; other site 1179773016789 KMSKS motif; other site 1179773016790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773016791 RNA binding surface [nucleotide binding]; other site 1179773016792 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1179773016793 Ca2+ binding site [ion binding]; other site 1179773016794 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773016795 EF-hand domain pair; Region: EF_hand_5; pfam13499 1179773016796 Ca2+ binding site [ion binding]; other site 1179773016797 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1179773016798 Ca2+ binding site [ion binding]; other site 1179773016799 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1179773016800 active site 1179773016801 DNA binding site [nucleotide binding] 1179773016802 argininosuccinate lyase; Provisional; Region: PRK00855 1179773016803 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1179773016804 active sites [active] 1179773016805 tetramer interface [polypeptide binding]; other site 1179773016806 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 1179773016807 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 1179773016808 Arginine repressor [Transcription]; Region: ArgR; COG1438 1179773016809 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1179773016810 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1179773016811 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1179773016812 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1179773016813 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1179773016814 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1179773016815 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773016816 inhibitor-cofactor binding pocket; inhibition site 1179773016817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773016818 catalytic residue [active] 1179773016819 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1179773016820 feedback inhibition sensing region; other site 1179773016821 homohexameric interface [polypeptide binding]; other site 1179773016822 nucleotide binding site [chemical binding]; other site 1179773016823 N-acetyl-L-glutamate binding site [chemical binding]; other site 1179773016824 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1179773016825 heterotetramer interface [polypeptide binding]; other site 1179773016826 active site pocket [active] 1179773016827 cleavage site 1179773016828 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1179773016829 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1179773016830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773016831 S-adenosylmethionine binding site [chemical binding]; other site 1179773016832 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1179773016833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773016834 motif II; other site 1179773016835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773016836 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1179773016837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773016838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773016839 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773016840 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1179773016841 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1179773016842 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1179773016843 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1179773016844 putative tRNA-binding site [nucleotide binding]; other site 1179773016845 B3/4 domain; Region: B3_4; pfam03483 1179773016846 tRNA synthetase B5 domain; Region: B5; smart00874 1179773016847 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1179773016848 dimer interface [polypeptide binding]; other site 1179773016849 motif 1; other site 1179773016850 motif 3; other site 1179773016851 motif 2; other site 1179773016852 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1179773016853 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1179773016854 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1179773016855 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1179773016856 dimer interface [polypeptide binding]; other site 1179773016857 motif 1; other site 1179773016858 active site 1179773016859 motif 2; other site 1179773016860 motif 3; other site 1179773016861 HSP90 family protein; Provisional; Region: PRK14083 1179773016862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773016863 Mg2+ binding site [ion binding]; other site 1179773016864 G-X-G motif; other site 1179773016865 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1179773016866 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1179773016867 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1179773016868 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1179773016869 23S rRNA binding site [nucleotide binding]; other site 1179773016870 L21 binding site [polypeptide binding]; other site 1179773016871 L13 binding site [polypeptide binding]; other site 1179773016872 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1179773016873 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1179773016874 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1179773016875 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1179773016876 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773016877 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773016878 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773016879 calcium binding site 2 [ion binding]; other site 1179773016880 active site 1179773016881 catalytic triad [active] 1179773016882 calcium binding site 1 [ion binding]; other site 1179773016883 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1179773016884 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1179773016885 dimerization interface [polypeptide binding]; other site 1179773016886 mannose binding site [chemical binding]; other site 1179773016887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773016888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773016889 non-specific DNA binding site [nucleotide binding]; other site 1179773016890 salt bridge; other site 1179773016891 sequence-specific DNA binding site [nucleotide binding]; other site 1179773016892 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773016893 homotrimer interaction site [polypeptide binding]; other site 1179773016894 putative active site [active] 1179773016895 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773016896 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773016897 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773016898 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773016899 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1179773016900 substrate binding site [chemical binding]; other site 1179773016901 ATP binding site [chemical binding]; other site 1179773016902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1179773016903 dimer interface [polypeptide binding]; other site 1179773016904 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1179773016905 active site 1179773016906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773016907 substrate binding site [chemical binding]; other site 1179773016908 catalytic residue [active] 1179773016909 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1179773016910 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1179773016911 active site 1179773016912 putative substrate binding pocket [chemical binding]; other site 1179773016913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773016914 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1179773016915 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773016916 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773016917 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773016918 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773016919 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773016920 hydrophobic ligand binding site; other site 1179773016921 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1179773016922 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1179773016923 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1179773016924 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1179773016925 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1179773016926 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773016927 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1179773016928 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1179773016929 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1179773016930 oligomeric interface; other site 1179773016931 putative active site [active] 1179773016932 homodimer interface [polypeptide binding]; other site 1179773016933 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1179773016934 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1179773016935 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773016936 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1179773016937 FMN binding site [chemical binding]; other site 1179773016938 active site 1179773016939 substrate binding site [chemical binding]; other site 1179773016940 catalytic residue [active] 1179773016941 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773016942 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773016943 DNA binding residues [nucleotide binding] 1179773016944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773016945 Coenzyme A binding pocket [chemical binding]; other site 1179773016946 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1179773016947 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1179773016948 putative ADP-ribose binding site [chemical binding]; other site 1179773016949 putative active site [active] 1179773016950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773016952 active site 1179773016953 phosphorylation site [posttranslational modification] 1179773016954 intermolecular recognition site; other site 1179773016955 dimerization interface [polypeptide binding]; other site 1179773016956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016957 DNA binding residues [nucleotide binding] 1179773016958 dimerization interface [polypeptide binding]; other site 1179773016959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773016960 Histidine kinase; Region: HisKA_3; pfam07730 1179773016961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773016962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773016963 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773016964 putative dimerization interface [polypeptide binding]; other site 1179773016965 Class I aldolases; Region: Aldolase_Class_I; cl17187 1179773016966 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1179773016967 catalytic residue [active] 1179773016968 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1179773016969 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1179773016970 RNA/DNA hybrid binding site [nucleotide binding]; other site 1179773016971 active site 1179773016972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773016973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773016974 active site 1179773016975 phosphorylation site [posttranslational modification] 1179773016976 intermolecular recognition site; other site 1179773016977 dimerization interface [polypeptide binding]; other site 1179773016978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773016979 DNA binding residues [nucleotide binding] 1179773016980 dimerization interface [polypeptide binding]; other site 1179773016981 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773016982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773016983 homodimer interface [polypeptide binding]; other site 1179773016984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773016985 catalytic residue [active] 1179773016986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773016987 dimerization interface [polypeptide binding]; other site 1179773016988 putative DNA binding site [nucleotide binding]; other site 1179773016989 putative Zn2+ binding site [ion binding]; other site 1179773016990 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1179773016991 putative hydrophobic ligand binding site [chemical binding]; other site 1179773016992 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1179773016993 hydrophobic ligand binding site; other site 1179773016994 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1179773016995 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773016996 cleavage site 1179773016997 active site 1179773016998 substrate binding sites [chemical binding]; other site 1179773016999 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1179773017000 DNA polymerase IV; Validated; Region: PRK03352 1179773017001 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1179773017002 active site 1179773017003 DNA binding site [nucleotide binding] 1179773017004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773017005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773017006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773017007 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1179773017008 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1179773017009 Beta propeller domain; Region: Beta_propel; pfam09826 1179773017010 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1179773017011 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1179773017012 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1179773017013 RES domain; Region: RES; pfam08808 1179773017014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773017015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773017016 non-specific DNA binding site [nucleotide binding]; other site 1179773017017 salt bridge; other site 1179773017018 sequence-specific DNA binding site [nucleotide binding]; other site 1179773017019 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1179773017020 nudix motif; other site 1179773017021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773017022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773017023 Coenzyme A binding pocket [chemical binding]; other site 1179773017024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773017025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773017026 ligand binding site [chemical binding]; other site 1179773017027 flexible hinge region; other site 1179773017028 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1179773017029 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1179773017030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773017031 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1179773017032 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773017033 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1179773017034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773017035 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1179773017036 Walker A/P-loop; other site 1179773017037 ATP binding site [chemical binding]; other site 1179773017038 Q-loop/lid; other site 1179773017039 ABC transporter signature motif; other site 1179773017040 Walker B; other site 1179773017041 D-loop; other site 1179773017042 H-loop/switch region; other site 1179773017043 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1179773017044 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773017045 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773017046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773017047 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773017048 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1179773017049 excinuclease ABC subunit B; Provisional; Region: PRK05298 1179773017050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773017051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773017052 nucleotide binding region [chemical binding]; other site 1179773017053 ATP-binding site [chemical binding]; other site 1179773017054 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1179773017055 UvrB/uvrC motif; Region: UVR; pfam02151 1179773017056 Protein of unknown function (DUF402); Region: DUF402; cl00979 1179773017057 Protein of unknown function (DUF402); Region: DUF402; cl00979 1179773017058 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1179773017059 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1179773017060 CoA-binding site [chemical binding]; other site 1179773017061 ATP-binding [chemical binding]; other site 1179773017062 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1179773017063 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1179773017064 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1179773017065 RNA binding site [nucleotide binding]; other site 1179773017066 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1179773017067 RNA binding site [nucleotide binding]; other site 1179773017068 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1179773017069 RNA binding site [nucleotide binding]; other site 1179773017070 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1179773017071 RNA binding site [nucleotide binding]; other site 1179773017072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773017073 S-adenosylmethionine binding site [chemical binding]; other site 1179773017074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773017075 Coenzyme A binding pocket [chemical binding]; other site 1179773017076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773017077 Walker A/P-loop; other site 1179773017078 ATP binding site [chemical binding]; other site 1179773017079 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773017080 G2 box; other site 1179773017081 Switch I region; other site 1179773017082 G3 box; other site 1179773017083 Switch II region; other site 1179773017084 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1179773017085 Predicted membrane protein [Function unknown]; Region: COG1511 1179773017086 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1179773017087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017089 short chain dehydrogenase; Provisional; Region: PRK08309 1179773017090 AAA domain; Region: AAA_17; pfam13207 1179773017091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017092 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1179773017093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773017094 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773017095 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773017096 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1179773017097 Caspase domain; Region: Peptidase_C14; pfam00656 1179773017098 DNA polymerase I; Provisional; Region: PRK05755 1179773017099 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1179773017100 active site 1179773017101 metal binding site 1 [ion binding]; metal-binding site 1179773017102 putative 5' ssDNA interaction site; other site 1179773017103 metal binding site 3; metal-binding site 1179773017104 metal binding site 2 [ion binding]; metal-binding site 1179773017105 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1179773017106 putative DNA binding site [nucleotide binding]; other site 1179773017107 putative metal binding site [ion binding]; other site 1179773017108 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1179773017109 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1179773017110 active site 1179773017111 DNA binding site [nucleotide binding] 1179773017112 catalytic site [active] 1179773017113 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773017114 CoenzymeA binding site [chemical binding]; other site 1179773017115 subunit interaction site [polypeptide binding]; other site 1179773017116 PHB binding site; other site 1179773017117 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1179773017118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1179773017119 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1179773017120 Walker A/P-loop; other site 1179773017121 ATP binding site [chemical binding]; other site 1179773017122 Q-loop/lid; other site 1179773017123 ABC transporter signature motif; other site 1179773017124 Walker B; other site 1179773017125 D-loop; other site 1179773017126 H-loop/switch region; other site 1179773017127 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1179773017128 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1179773017129 Walker A/P-loop; other site 1179773017130 ATP binding site [chemical binding]; other site 1179773017131 Q-loop/lid; other site 1179773017132 ABC transporter signature motif; other site 1179773017133 Walker B; other site 1179773017134 D-loop; other site 1179773017135 H-loop/switch region; other site 1179773017136 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1179773017137 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1179773017138 TM-ABC transporter signature motif; other site 1179773017139 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1179773017140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773017141 TM-ABC transporter signature motif; other site 1179773017142 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1179773017143 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1179773017144 dimerization interface [polypeptide binding]; other site 1179773017145 ligand binding site [chemical binding]; other site 1179773017146 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1179773017147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773017148 active site 1179773017149 phosphorylation site [posttranslational modification] 1179773017150 intermolecular recognition site; other site 1179773017151 dimerization interface [polypeptide binding]; other site 1179773017152 ANTAR domain; Region: ANTAR; pfam03861 1179773017153 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1179773017154 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1179773017155 PYR/PP interface [polypeptide binding]; other site 1179773017156 dimer interface [polypeptide binding]; other site 1179773017157 TPP binding site [chemical binding]; other site 1179773017158 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773017159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1179773017160 TPP-binding site [chemical binding]; other site 1179773017161 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773017162 DinB superfamily; Region: DinB_2; pfam12867 1179773017163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773017164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773017165 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773017166 putative dimerization interface [polypeptide binding]; other site 1179773017167 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773017168 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773017169 NAD(P) binding site [chemical binding]; other site 1179773017170 catalytic residues [active] 1179773017171 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1179773017172 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1179773017173 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1179773017174 NAD(P) binding pocket [chemical binding]; other site 1179773017175 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1179773017176 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773017177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773017178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773017179 active site 1179773017180 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773017181 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1179773017182 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1179773017183 homotrimer interaction site [polypeptide binding]; other site 1179773017184 putative active site [active] 1179773017185 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773017186 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773017187 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1179773017188 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1179773017189 putative transporter; Provisional; Region: PRK11021 1179773017190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017192 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773017193 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773017194 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1179773017195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773017196 ATP binding site [chemical binding]; other site 1179773017197 putative Mg++ binding site [ion binding]; other site 1179773017198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773017199 nucleotide binding region [chemical binding]; other site 1179773017200 ATP-binding site [chemical binding]; other site 1179773017201 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1179773017202 HRDC domain; Region: HRDC; pfam00570 1179773017203 TIR domain; Region: TIR_2; pfam13676 1179773017204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773017205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773017206 non-specific DNA binding site [nucleotide binding]; other site 1179773017207 salt bridge; other site 1179773017208 sequence-specific DNA binding site [nucleotide binding]; other site 1179773017209 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1179773017210 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1179773017211 active site 1179773017212 octamer interface [polypeptide binding]; other site 1179773017213 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1179773017214 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1179773017215 metal binding site [ion binding]; metal-binding site 1179773017216 dimer interface [polypeptide binding]; other site 1179773017217 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1179773017218 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1179773017219 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1179773017220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1179773017221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773017222 dimer interface [polypeptide binding]; other site 1179773017223 conserved gate region; other site 1179773017224 putative PBP binding loops; other site 1179773017225 ABC-ATPase subunit interface; other site 1179773017226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1179773017227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773017228 putative PBP binding loops; other site 1179773017229 dimer interface [polypeptide binding]; other site 1179773017230 ABC-ATPase subunit interface; other site 1179773017231 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1179773017232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773017233 Walker A/P-loop; other site 1179773017234 ATP binding site [chemical binding]; other site 1179773017235 Q-loop/lid; other site 1179773017236 ABC transporter signature motif; other site 1179773017237 Walker B; other site 1179773017238 D-loop; other site 1179773017239 H-loop/switch region; other site 1179773017240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773017241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1179773017242 Walker A/P-loop; other site 1179773017243 ATP binding site [chemical binding]; other site 1179773017244 Q-loop/lid; other site 1179773017245 ABC transporter signature motif; other site 1179773017246 Walker B; other site 1179773017247 D-loop; other site 1179773017248 H-loop/switch region; other site 1179773017249 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1179773017250 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773017251 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773017252 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1179773017253 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773017254 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1179773017255 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773017256 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1179773017257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773017258 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1179773017259 FtsX-like permease family; Region: FtsX; pfam02687 1179773017260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773017261 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773017262 Walker A/P-loop; other site 1179773017263 ATP binding site [chemical binding]; other site 1179773017264 Q-loop/lid; other site 1179773017265 ABC transporter signature motif; other site 1179773017266 Walker B; other site 1179773017267 D-loop; other site 1179773017268 H-loop/switch region; other site 1179773017269 Putative sensor; Region: Sensor; pfam13796 1179773017270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773017271 Histidine kinase; Region: HisKA_3; pfam07730 1179773017272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773017273 ATP binding site [chemical binding]; other site 1179773017274 Mg2+ binding site [ion binding]; other site 1179773017275 G-X-G motif; other site 1179773017276 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773017277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773017278 active site 1179773017279 phosphorylation site [posttranslational modification] 1179773017280 intermolecular recognition site; other site 1179773017281 dimerization interface [polypeptide binding]; other site 1179773017282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773017283 DNA binding residues [nucleotide binding] 1179773017284 dimerization interface [polypeptide binding]; other site 1179773017285 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1179773017286 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1179773017287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1179773017288 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1179773017289 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1179773017290 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773017291 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773017292 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773017293 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773017294 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773017295 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773017296 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1179773017297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773017298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773017299 DNA binding residues [nucleotide binding] 1179773017300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017302 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1179773017303 putative homotetramer interface [polypeptide binding]; other site 1179773017304 putative homodimer interface [polypeptide binding]; other site 1179773017305 putative allosteric switch controlling residues; other site 1179773017306 putative metal binding site [ion binding]; other site 1179773017307 Lsr2; Region: Lsr2; pfam11774 1179773017308 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1179773017309 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1179773017310 glutamine binding [chemical binding]; other site 1179773017311 catalytic triad [active] 1179773017312 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1179773017313 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1179773017314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1179773017315 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773017316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773017317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773017318 DNA binding residues [nucleotide binding] 1179773017319 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1179773017320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773017321 putative active site [active] 1179773017322 putative metal binding site [ion binding]; other site 1179773017323 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1179773017324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1179773017325 dimer interface [polypeptide binding]; other site 1179773017326 active site 1179773017327 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773017328 catalytic residues [active] 1179773017329 substrate binding site [chemical binding]; other site 1179773017330 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1179773017331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773017332 S-adenosylmethionine binding site [chemical binding]; other site 1179773017333 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773017334 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773017335 DNA binding residues [nucleotide binding] 1179773017336 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1179773017337 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1179773017338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773017339 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1179773017340 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1179773017341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773017342 S-adenosylmethionine binding site [chemical binding]; other site 1179773017343 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773017344 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773017345 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1179773017346 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1179773017347 dimer interface [polypeptide binding]; other site 1179773017348 active site 1179773017349 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1179773017350 folate binding site [chemical binding]; other site 1179773017351 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1179773017352 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1179773017353 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1179773017354 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1179773017355 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1179773017356 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1179773017357 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1179773017358 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773017359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773017360 active site 1179773017361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773017362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773017363 Coenzyme A binding pocket [chemical binding]; other site 1179773017364 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1179773017365 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773017366 dimer interface [polypeptide binding]; other site 1179773017367 active site 1179773017368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773017369 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1179773017370 substrate binding site [chemical binding]; other site 1179773017371 oxyanion hole (OAH) forming residues; other site 1179773017372 trimer interface [polypeptide binding]; other site 1179773017373 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773017374 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773017375 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1179773017376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773017377 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773017378 active site 1179773017379 metal binding site [ion binding]; metal-binding site 1179773017380 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1179773017381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773017382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773017383 Electron transfer DM13; Region: DM13; pfam10517 1179773017384 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773017385 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773017386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773017387 DNA binding site [nucleotide binding] 1179773017388 domain linker motif; other site 1179773017389 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1179773017390 putative dimerization interface [polypeptide binding]; other site 1179773017391 putative ligand binding site [chemical binding]; other site 1179773017392 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1179773017393 beta-galactosidase; Region: BGL; TIGR03356 1179773017394 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1179773017395 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773017396 FtsX-like permease family; Region: FtsX; pfam02687 1179773017397 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1179773017398 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1179773017399 FtsX-like permease family; Region: FtsX; pfam02687 1179773017400 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773017401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773017402 Walker A/P-loop; other site 1179773017403 ATP binding site [chemical binding]; other site 1179773017404 Q-loop/lid; other site 1179773017405 ABC transporter signature motif; other site 1179773017406 Walker B; other site 1179773017407 D-loop; other site 1179773017408 H-loop/switch region; other site 1179773017409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773017410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773017411 DNA binding residues [nucleotide binding] 1179773017412 dimerization interface [polypeptide binding]; other site 1179773017413 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1179773017414 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773017415 active site 1179773017416 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1179773017417 Chitinase C; Region: ChiC; pfam06483 1179773017418 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1179773017419 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1179773017420 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773017421 DNA binding site [nucleotide binding] 1179773017422 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773017423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773017424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773017425 binding surface 1179773017426 TPR motif; other site 1179773017427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773017428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773017429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773017430 binding surface 1179773017431 TPR motif; other site 1179773017432 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1179773017433 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1179773017434 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773017435 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773017436 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1179773017437 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1179773017438 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1179773017439 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1179773017440 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1179773017441 active site clefts [active] 1179773017442 zinc binding site [ion binding]; other site 1179773017443 dimer interface [polypeptide binding]; other site 1179773017444 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773017445 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1179773017446 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1179773017447 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773017448 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1179773017449 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773017450 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1179773017451 putative DNA binding site [nucleotide binding]; other site 1179773017452 putative Zn2+ binding site [ion binding]; other site 1179773017453 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773017454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773017455 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773017456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773017457 tyrosine decarboxylase; Region: PLN02880 1179773017458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773017459 catalytic residue [active] 1179773017460 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1179773017461 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1179773017462 active site 1179773017463 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1179773017464 catalytic triad [active] 1179773017465 dimer interface [polypeptide binding]; other site 1179773017466 pyruvate kinase; Provisional; Region: PRK06247 1179773017467 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1179773017468 domain interfaces; other site 1179773017469 active site 1179773017470 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1179773017471 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1179773017472 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1179773017473 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1179773017474 homodimer interface [polypeptide binding]; other site 1179773017475 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1179773017476 active site 1179773017477 TDP-binding site; other site 1179773017478 acceptor substrate-binding pocket; other site 1179773017479 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773017480 homotrimer interaction site [polypeptide binding]; other site 1179773017481 putative active site [active] 1179773017482 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773017483 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773017484 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1179773017485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773017486 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1179773017487 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1179773017488 active site 1179773017489 dimer interface [polypeptide binding]; other site 1179773017490 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1179773017491 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1179773017492 active site 1179773017493 FMN binding site [chemical binding]; other site 1179773017494 substrate binding site [chemical binding]; other site 1179773017495 3Fe-4S cluster binding site [ion binding]; other site 1179773017496 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1179773017497 domain interface; other site 1179773017498 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1179773017499 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1179773017500 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1179773017501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773017502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773017503 dimerization interface [polypeptide binding]; other site 1179773017504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773017505 dimer interface [polypeptide binding]; other site 1179773017506 phosphorylation site [posttranslational modification] 1179773017507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773017508 ATP binding site [chemical binding]; other site 1179773017509 Mg2+ binding site [ion binding]; other site 1179773017510 G-X-G motif; other site 1179773017511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773017512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773017513 active site 1179773017514 phosphorylation site [posttranslational modification] 1179773017515 intermolecular recognition site; other site 1179773017516 dimerization interface [polypeptide binding]; other site 1179773017517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773017518 DNA binding site [nucleotide binding] 1179773017519 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1179773017520 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773017521 putative active site [active] 1179773017522 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1179773017523 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1179773017524 substrate binding site [chemical binding]; other site 1179773017525 active site 1179773017526 catalytic residues [active] 1179773017527 heterodimer interface [polypeptide binding]; other site 1179773017528 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1179773017529 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1179773017530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773017531 catalytic residue [active] 1179773017532 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1179773017533 active site 1179773017534 ribulose/triose binding site [chemical binding]; other site 1179773017535 phosphate binding site [ion binding]; other site 1179773017536 substrate (anthranilate) binding pocket [chemical binding]; other site 1179773017537 product (indole) binding pocket [chemical binding]; other site 1179773017538 anthranilate synthase component I; Provisional; Region: PRK13571 1179773017539 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1179773017540 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1179773017541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017543 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1179773017544 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1179773017545 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1179773017546 substrate binding site [chemical binding]; other site 1179773017547 glutamase interaction surface [polypeptide binding]; other site 1179773017548 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773017549 DNA-binding site [nucleotide binding]; DNA binding site 1179773017550 RNA-binding motif; other site 1179773017551 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1179773017552 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773017553 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773017554 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1179773017555 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1179773017556 catalytic residues [active] 1179773017557 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1179773017558 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1179773017559 putative active site [active] 1179773017560 oxyanion strand; other site 1179773017561 catalytic triad [active] 1179773017562 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1179773017563 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1179773017564 PYR/PP interface [polypeptide binding]; other site 1179773017565 dimer interface [polypeptide binding]; other site 1179773017566 TPP binding site [chemical binding]; other site 1179773017567 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773017568 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1179773017569 TPP-binding site [chemical binding]; other site 1179773017570 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773017571 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1179773017572 DNA binding residues [nucleotide binding] 1179773017573 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1179773017574 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1179773017575 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1179773017576 putative active site pocket [active] 1179773017577 4-fold oligomerization interface [polypeptide binding]; other site 1179773017578 metal binding residues [ion binding]; metal-binding site 1179773017579 3-fold/trimer interface [polypeptide binding]; other site 1179773017580 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1179773017581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773017582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773017583 homodimer interface [polypeptide binding]; other site 1179773017584 catalytic residue [active] 1179773017585 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1179773017586 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1179773017587 NAD binding site [chemical binding]; other site 1179773017588 dimerization interface [polypeptide binding]; other site 1179773017589 product binding site; other site 1179773017590 substrate binding site [chemical binding]; other site 1179773017591 zinc binding site [ion binding]; other site 1179773017592 catalytic residues [active] 1179773017593 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1179773017594 putative active site [active] 1179773017595 Zn binding site [ion binding]; other site 1179773017596 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773017597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773017598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773017599 catalytic residue [active] 1179773017600 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1179773017601 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1179773017602 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1179773017603 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1179773017604 putative active site [active] 1179773017605 catalytic triad [active] 1179773017606 putative dimer interface [polypeptide binding]; other site 1179773017607 PRC-barrel domain; Region: PRC; pfam05239 1179773017608 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1179773017609 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1179773017610 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1179773017611 dimerization interface [polypeptide binding]; other site 1179773017612 active site 1179773017613 L-aspartate oxidase; Provisional; Region: PRK07804 1179773017614 L-aspartate oxidase; Provisional; Region: PRK06175 1179773017615 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1179773017616 quinolinate synthetase; Provisional; Region: PRK09375 1179773017617 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1179773017618 nudix motif; other site 1179773017619 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1179773017620 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1179773017621 benzoate transport; Region: 2A0115; TIGR00895 1179773017622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773017623 putative substrate translocation pore; other site 1179773017624 hypothetical protein; Provisional; Region: PRK05463 1179773017625 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1179773017626 biotin synthase; Region: bioB; TIGR00433 1179773017627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773017628 FeS/SAM binding site; other site 1179773017629 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1179773017630 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1179773017631 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1179773017632 catalytic residues [active] 1179773017633 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1179773017634 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773017635 inhibitor-cofactor binding pocket; inhibition site 1179773017636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773017637 catalytic residue [active] 1179773017638 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773017639 Cytochrome P450; Region: p450; cl12078 1179773017640 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1179773017641 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1179773017642 active site 1179773017643 PHP Thumb interface [polypeptide binding]; other site 1179773017644 metal binding site [ion binding]; metal-binding site 1179773017645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1179773017646 generic binding surface II; other site 1179773017647 generic binding surface I; other site 1179773017648 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773017649 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773017650 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1179773017651 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1179773017652 active site 1179773017653 lipoprotein signal peptidase; Provisional; Region: PRK14764 1179773017654 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1179773017655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773017656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773017657 catalytic residue [active] 1179773017658 potassium/proton antiporter; Reviewed; Region: PRK05326 1179773017659 TrkA-C domain; Region: TrkA_C; pfam02080 1179773017660 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1179773017661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773017663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773017664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773017665 DNA binding residues [nucleotide binding] 1179773017666 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773017667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773017668 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1179773017669 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1179773017670 HIGH motif; other site 1179773017671 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773017672 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1179773017673 active site 1179773017674 KMSKS motif; other site 1179773017675 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1179773017676 tRNA binding surface [nucleotide binding]; other site 1179773017677 anticodon binding site; other site 1179773017678 Caspase domain; Region: Peptidase_C14; pfam00656 1179773017679 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773017680 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773017681 structural tetrad; other site 1179773017682 DivIVA domain; Region: DivI1A_domain; TIGR03544 1179773017683 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1179773017684 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1179773017685 Predicted integral membrane protein [Function unknown]; Region: COG0762 1179773017686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1179773017687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1179773017688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773017689 catalytic residue [active] 1179773017690 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1179773017691 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1179773017692 cell division protein FtsZ; Validated; Region: PRK09330 1179773017693 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1179773017694 nucleotide binding site [chemical binding]; other site 1179773017695 SulA interaction site; other site 1179773017696 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773017697 DinB superfamily; Region: DinB_2; pfam12867 1179773017698 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1179773017699 Cell division protein FtsQ; Region: FtsQ; pfam03799 1179773017700 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1179773017701 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1179773017702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773017703 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1179773017704 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1179773017705 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1179773017706 active site 1179773017707 homodimer interface [polypeptide binding]; other site 1179773017708 cell division protein FtsW; Region: ftsW; TIGR02614 1179773017709 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1179773017710 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773017711 putative active site [active] 1179773017712 putative substrate binding site [chemical binding]; other site 1179773017713 ATP binding site [chemical binding]; other site 1179773017714 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773017715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773017716 non-specific DNA binding site [nucleotide binding]; other site 1179773017717 salt bridge; other site 1179773017718 sequence-specific DNA binding site [nucleotide binding]; other site 1179773017719 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1179773017720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773017721 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1179773017722 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1179773017723 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1179773017724 Mg++ binding site [ion binding]; other site 1179773017725 putative catalytic motif [active] 1179773017726 putative substrate binding site [chemical binding]; other site 1179773017727 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1179773017728 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1179773017729 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773017730 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1179773017731 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1179773017732 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1179773017733 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1179773017734 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1179773017735 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1179773017736 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1179773017737 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1179773017738 MraW methylase family; Region: Methyltransf_5; cl17771 1179773017739 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1179773017740 cell division protein MraZ; Reviewed; Region: PRK00326 1179773017741 MraZ protein; Region: MraZ; pfam02381 1179773017742 MraZ protein; Region: MraZ; pfam02381 1179773017743 MoxR-like ATPases [General function prediction only]; Region: COG0714 1179773017744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773017745 ATP binding site [chemical binding]; other site 1179773017746 Walker A motif; other site 1179773017747 Walker B motif; other site 1179773017748 arginine finger; other site 1179773017749 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1179773017750 Protein of unknown function DUF58; Region: DUF58; pfam01882 1179773017751 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1179773017752 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1179773017753 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1179773017754 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773017755 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773017756 ligand binding site [chemical binding]; other site 1179773017757 flexible hinge region; other site 1179773017758 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1179773017759 putative switch regulator; other site 1179773017760 non-specific DNA interactions [nucleotide binding]; other site 1179773017761 DNA binding site [nucleotide binding] 1179773017762 sequence specific DNA binding site [nucleotide binding]; other site 1179773017763 putative cAMP binding site [chemical binding]; other site 1179773017764 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1179773017765 active site 1179773017766 DNA polymerase IV; Validated; Region: PRK02406 1179773017767 DNA binding site [nucleotide binding] 1179773017768 Amidohydrolase; Region: Amidohydro_2; pfam04909 1179773017769 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1179773017770 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1179773017771 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1179773017772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773017773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773017774 DNA binding residues [nucleotide binding] 1179773017775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773017776 S-adenosylmethionine binding site [chemical binding]; other site 1179773017777 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773017778 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1179773017779 P-loop; other site 1179773017780 Magnesium ion binding site [ion binding]; other site 1179773017781 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773017782 Magnesium ion binding site [ion binding]; other site 1179773017783 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1179773017784 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1179773017785 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1179773017786 putative DNA binding site [nucleotide binding]; other site 1179773017787 catalytic residue [active] 1179773017788 putative H2TH interface [polypeptide binding]; other site 1179773017789 putative catalytic residues [active] 1179773017790 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1179773017791 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1179773017792 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1179773017793 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1179773017794 quinone interaction residues [chemical binding]; other site 1179773017795 active site 1179773017796 catalytic residues [active] 1179773017797 FMN binding site [chemical binding]; other site 1179773017798 substrate binding site [chemical binding]; other site 1179773017799 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1179773017800 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1179773017801 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1179773017802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773017803 non-specific DNA binding site [nucleotide binding]; other site 1179773017804 salt bridge; other site 1179773017805 sequence-specific DNA binding site [nucleotide binding]; other site 1179773017806 Competence-damaged protein; Region: CinA; pfam02464 1179773017807 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1179773017808 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1179773017809 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1179773017810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773017811 FeS/SAM binding site; other site 1179773017812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773017813 Coenzyme A binding pocket [chemical binding]; other site 1179773017814 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773017815 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773017816 DNA binding residues [nucleotide binding] 1179773017817 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1179773017818 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1179773017819 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773017820 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1179773017821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773017822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773017823 putative acyl-acceptor binding pocket; other site 1179773017824 threonine and homoserine efflux system; Provisional; Region: PRK10532 1179773017825 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1179773017826 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773017827 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1179773017828 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1179773017829 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1179773017830 dimer interface [polypeptide binding]; other site 1179773017831 active site 1179773017832 catalytic residue [active] 1179773017833 TIGR03085 family protein; Region: TIGR03085 1179773017834 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1179773017835 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773017836 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773017837 active site 1179773017838 ATP binding site [chemical binding]; other site 1179773017839 substrate binding site [chemical binding]; other site 1179773017840 activation loop (A-loop); other site 1179773017841 Septum formation; Region: Septum_form; pfam13845 1179773017842 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1179773017843 Family description; Region: ACT_7; pfam13840 1179773017844 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1179773017845 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1179773017846 putative ADP-ribose binding site [chemical binding]; other site 1179773017847 putative active site [active] 1179773017848 HicB family; Region: HicB; pfam05534 1179773017849 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1179773017850 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1179773017851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1179773017852 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1179773017853 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1179773017854 EamA-like transporter family; Region: EamA; pfam00892 1179773017855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773017856 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773017857 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1179773017858 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1179773017859 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1179773017860 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1179773017861 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1179773017862 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1179773017863 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1179773017864 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1179773017865 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1179773017866 oligomer interface [polypeptide binding]; other site 1179773017867 RNA binding site [nucleotide binding]; other site 1179773017868 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1179773017869 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1179773017870 RNase E interface [polypeptide binding]; other site 1179773017871 trimer interface [polypeptide binding]; other site 1179773017872 active site 1179773017873 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1179773017874 putative nucleic acid binding region [nucleotide binding]; other site 1179773017875 G-X-X-G motif; other site 1179773017876 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1179773017877 RNA binding site [nucleotide binding]; other site 1179773017878 domain interface; other site 1179773017879 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1179773017880 16S/18S rRNA binding site [nucleotide binding]; other site 1179773017881 S13e-L30e interaction site [polypeptide binding]; other site 1179773017882 25S rRNA binding site [nucleotide binding]; other site 1179773017883 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1179773017884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773017885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773017886 non-specific DNA binding site [nucleotide binding]; other site 1179773017887 salt bridge; other site 1179773017888 sequence-specific DNA binding site [nucleotide binding]; other site 1179773017889 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1179773017890 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1179773017891 active site 1179773017892 Riboflavin kinase; Region: Flavokinase; smart00904 1179773017893 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1179773017894 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1179773017895 RNA binding site [nucleotide binding]; other site 1179773017896 active site 1179773017897 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1179773017898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773017899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773017900 putative substrate translocation pore; other site 1179773017901 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1179773017902 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1179773017903 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1179773017904 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1179773017905 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1179773017906 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1179773017907 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1179773017908 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1179773017909 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1179773017910 G1 box; other site 1179773017911 putative GEF interaction site [polypeptide binding]; other site 1179773017912 GTP/Mg2+ binding site [chemical binding]; other site 1179773017913 Switch I region; other site 1179773017914 G2 box; other site 1179773017915 G3 box; other site 1179773017916 Switch II region; other site 1179773017917 G4 box; other site 1179773017918 G5 box; other site 1179773017919 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1179773017920 Translation-initiation factor 2; Region: IF-2; pfam11987 1179773017921 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1179773017922 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1179773017923 putative RNA binding cleft [nucleotide binding]; other site 1179773017924 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1179773017925 NusA N-terminal domain; Region: NusA_N; pfam08529 1179773017926 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1179773017927 RNA binding site [nucleotide binding]; other site 1179773017928 homodimer interface [polypeptide binding]; other site 1179773017929 NusA-like KH domain; Region: KH_5; pfam13184 1179773017930 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1179773017931 G-X-X-G motif; other site 1179773017932 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1179773017933 Sm and related proteins; Region: Sm_like; cl00259 1179773017934 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1179773017935 dinuclear metal binding motif [ion binding]; other site 1179773017936 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773017937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773017938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773017939 catalytic residue [active] 1179773017940 catalytic residue [active] 1179773017941 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773017942 CoenzymeA binding site [chemical binding]; other site 1179773017943 subunit interaction site [polypeptide binding]; other site 1179773017944 PHB binding site; other site 1179773017945 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1179773017946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773017947 NAD(P) binding site [chemical binding]; other site 1179773017948 active site 1179773017949 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1179773017950 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1179773017951 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1179773017952 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1179773017953 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773017954 motif 1; other site 1179773017955 dimer interface [polypeptide binding]; other site 1179773017956 active site 1179773017957 motif 2; other site 1179773017958 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1179773017959 putative deacylase active site [active] 1179773017960 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1179773017961 active site 1179773017962 motif 3; other site 1179773017963 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1179773017964 anticodon binding site; other site 1179773017965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773017966 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773017967 active site 1179773017968 hypothetical protein; Validated; Region: PRK02101 1179773017969 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1179773017970 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773017971 conserved cys residue [active] 1179773017972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773017973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773017974 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1179773017975 ATP binding site [chemical binding]; other site 1179773017976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773017977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773017978 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1179773017979 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1179773017980 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1179773017981 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1179773017982 ATP binding site [chemical binding]; other site 1179773017983 Mg++ binding site [ion binding]; other site 1179773017984 motif III; other site 1179773017985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773017986 nucleotide binding region [chemical binding]; other site 1179773017987 ATP-binding site [chemical binding]; other site 1179773017988 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773017989 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773017990 Predicted ATPase [General function prediction only]; Region: COG3903 1179773017991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773017992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773017993 TPR motif; other site 1179773017994 binding surface 1179773017995 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773017996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773017997 binding surface 1179773017998 TPR motif; other site 1179773017999 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018000 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1179773018001 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773018002 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773018003 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773018004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773018005 dimerization interface [polypeptide binding]; other site 1179773018006 putative DNA binding site [nucleotide binding]; other site 1179773018007 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773018008 putative Zn2+ binding site [ion binding]; other site 1179773018009 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1179773018010 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1179773018011 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1179773018012 homodimer interface [polypeptide binding]; other site 1179773018013 active site 1179773018014 SAM binding site [chemical binding]; other site 1179773018015 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1179773018016 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773018017 cleavage site 1179773018018 active site 1179773018019 substrate binding sites [chemical binding]; other site 1179773018020 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1179773018021 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1179773018022 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1179773018023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1179773018024 S-adenosylmethionine binding site [chemical binding]; other site 1179773018025 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1179773018026 active site 1179773018027 homodimer interface [polypeptide binding]; other site 1179773018028 SAM binding site [chemical binding]; other site 1179773018029 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1179773018030 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773018031 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1179773018032 catalytic triad [active] 1179773018033 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1179773018034 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1179773018035 homodimer interface [polypeptide binding]; other site 1179773018036 Walker A motif; other site 1179773018037 ATP binding site [chemical binding]; other site 1179773018038 hydroxycobalamin binding site [chemical binding]; other site 1179773018039 Walker B motif; other site 1179773018040 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1179773018041 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1179773018042 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1179773018043 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1179773018044 metal ion-dependent adhesion site (MIDAS); other site 1179773018045 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773018046 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773018047 NAD(P) binding site [chemical binding]; other site 1179773018048 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1179773018049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773018050 Cytochrome P450; Region: p450; cl12078 1179773018051 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1179773018052 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1179773018053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773018054 catalytic residue [active] 1179773018055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773018056 Coenzyme A binding pocket [chemical binding]; other site 1179773018057 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773018058 cleavage site 1179773018059 active site 1179773018060 substrate binding sites [chemical binding]; other site 1179773018061 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1179773018062 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773018063 active site 1179773018064 substrate binding sites [chemical binding]; other site 1179773018065 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1179773018066 cleavage site 1179773018067 active site 1179773018068 substrate binding sites [chemical binding]; other site 1179773018069 Peptidase family M48; Region: Peptidase_M48; pfam01435 1179773018070 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773018071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773018072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773018073 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773018074 active site 1179773018075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773018076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773018077 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1179773018078 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1179773018079 trimer interface [polypeptide binding]; other site 1179773018080 active site 1179773018081 substrate binding site [chemical binding]; other site 1179773018082 CoA binding site [chemical binding]; other site 1179773018083 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1179773018084 mycothione reductase; Reviewed; Region: PRK07846 1179773018085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773018086 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773018087 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1179773018088 substrate binding site [chemical binding]; other site 1179773018089 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1179773018090 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1179773018091 NodB motif; other site 1179773018092 active site 1179773018093 catalytic site [active] 1179773018094 metal binding site [ion binding]; metal-binding site 1179773018095 PBP superfamily domain; Region: PBP_like_2; cl17296 1179773018096 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1179773018097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773018098 Walker A motif; other site 1179773018099 ATP binding site [chemical binding]; other site 1179773018100 Walker B motif; other site 1179773018101 arginine finger; other site 1179773018102 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1179773018103 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1179773018104 nucleotidyl binding site; other site 1179773018105 metal binding site [ion binding]; metal-binding site 1179773018106 NB-ARC domain; Region: NB-ARC; pfam00931 1179773018107 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018108 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773018109 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1179773018110 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1179773018111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773018112 DNA-binding site [nucleotide binding]; DNA binding site 1179773018113 FCD domain; Region: FCD; pfam07729 1179773018114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773018115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773018116 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773018117 putative dimerization interface [polypeptide binding]; other site 1179773018118 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1179773018119 EamA-like transporter family; Region: EamA; pfam00892 1179773018120 EamA-like transporter family; Region: EamA; pfam00892 1179773018121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018124 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773018125 cobyric acid synthase; Provisional; Region: PRK00784 1179773018126 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1179773018127 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1179773018128 catalytic triad [active] 1179773018129 Thioesterase; Region: PKS_TE; smart00824 1179773018130 methionine aminopeptidase; Provisional; Region: PRK12318 1179773018131 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1179773018132 active site 1179773018133 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1179773018134 putative active site [active] 1179773018135 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1179773018136 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1179773018137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1179773018138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1179773018139 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1179773018140 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1179773018141 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773018142 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1179773018143 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1179773018144 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1179773018145 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1179773018146 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1179773018147 active site 1179773018148 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1179773018149 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1179773018150 putative substrate binding region [chemical binding]; other site 1179773018151 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1179773018152 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1179773018153 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1179773018154 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1179773018155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773018156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773018157 active site 1179773018158 phosphorylation site [posttranslational modification] 1179773018159 intermolecular recognition site; other site 1179773018160 dimerization interface [polypeptide binding]; other site 1179773018161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773018162 DNA binding residues [nucleotide binding] 1179773018163 dimerization interface [polypeptide binding]; other site 1179773018164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773018165 Histidine kinase; Region: HisKA_3; pfam07730 1179773018166 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773018167 ATP binding site [chemical binding]; other site 1179773018168 Mg2+ binding site [ion binding]; other site 1179773018169 G-X-G motif; other site 1179773018170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773018171 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1179773018172 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1179773018173 dimer interface [polypeptide binding]; other site 1179773018174 conserved gate region; other site 1179773018175 ABC-ATPase subunit interface; other site 1179773018176 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1179773018177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1179773018178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773018179 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1179773018180 Walker A/P-loop; other site 1179773018181 ATP binding site [chemical binding]; other site 1179773018182 Q-loop/lid; other site 1179773018183 ABC transporter signature motif; other site 1179773018184 Walker B; other site 1179773018185 D-loop; other site 1179773018186 H-loop/switch region; other site 1179773018187 TOBE domain; Region: TOBE_2; pfam08402 1179773018188 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1179773018189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773018190 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773018191 active site 1179773018192 ATP binding site [chemical binding]; other site 1179773018193 substrate binding site [chemical binding]; other site 1179773018194 activation loop (A-loop); other site 1179773018195 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773018196 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1179773018197 active site clefts [active] 1179773018198 zinc binding site [ion binding]; other site 1179773018199 dimer interface [polypeptide binding]; other site 1179773018200 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773018201 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1179773018202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773018203 FeS/SAM binding site; other site 1179773018204 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773018205 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773018206 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773018207 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773018208 active site 1179773018209 catalytic tetrad [active] 1179773018210 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1179773018211 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773018212 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773018213 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1179773018214 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1179773018215 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1179773018216 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1179773018217 hinge region; other site 1179773018218 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1179773018219 putative nucleotide binding site [chemical binding]; other site 1179773018220 uridine monophosphate binding site [chemical binding]; other site 1179773018221 homohexameric interface [polypeptide binding]; other site 1179773018222 elongation factor Ts; Provisional; Region: tsf; PRK09377 1179773018223 UBA/TS-N domain; Region: UBA; pfam00627 1179773018224 Elongation factor TS; Region: EF_TS; pfam00889 1179773018225 Elongation factor TS; Region: EF_TS; pfam00889 1179773018226 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1179773018227 rRNA interaction site [nucleotide binding]; other site 1179773018228 S8 interaction site; other site 1179773018229 putative laminin-1 binding site; other site 1179773018230 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1179773018231 Peptidase family M23; Region: Peptidase_M23; pfam01551 1179773018232 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1179773018233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773018234 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1179773018235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773018236 DNA binding residues [nucleotide binding] 1179773018237 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1179773018238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773018239 active site 1179773018240 DNA binding site [nucleotide binding] 1179773018241 Int/Topo IB signature motif; other site 1179773018242 DNA protecting protein DprA; Region: dprA; TIGR00732 1179773018243 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1179773018244 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1179773018245 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1179773018246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773018247 Walker A motif; other site 1179773018248 ATP binding site [chemical binding]; other site 1179773018249 Walker B motif; other site 1179773018250 arginine finger; other site 1179773018251 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1179773018252 hypothetical protein; Reviewed; Region: PRK12497 1179773018253 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1179773018254 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1179773018255 RNA/DNA hybrid binding site [nucleotide binding]; other site 1179773018256 active site 1179773018257 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1179773018258 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1179773018259 Catalytic site [active] 1179773018260 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1179773018261 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1179773018262 Catalytic site [active] 1179773018263 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1179773018264 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1179773018265 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1179773018266 RimM N-terminal domain; Region: RimM; pfam01782 1179773018267 PRC-barrel domain; Region: PRC; pfam05239 1179773018268 hypothetical protein; Provisional; Region: PRK02821 1179773018269 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1179773018270 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1179773018271 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1179773018272 putative active site [active] 1179773018273 CAAX protease self-immunity; Region: Abi; pfam02517 1179773018274 CAAX protease self-immunity; Region: Abi; pfam02517 1179773018275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773018276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773018277 active site 1179773018278 signal recognition particle protein; Provisional; Region: PRK10867 1179773018279 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1179773018280 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1179773018281 P loop; other site 1179773018282 GTP binding site [chemical binding]; other site 1179773018283 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1179773018284 PII uridylyl-transferase; Provisional; Region: PRK03381 1179773018285 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1179773018286 metal binding triad [ion binding]; metal-binding site 1179773018287 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1179773018288 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1179773018289 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1179773018290 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1179773018291 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1179773018292 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1179773018293 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773018294 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773018295 allantoicase; Provisional; Region: PRK13257 1179773018296 Allantoicase repeat; Region: Allantoicase; pfam03561 1179773018297 Allantoicase repeat; Region: Allantoicase; pfam03561 1179773018298 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1179773018299 allantoinase; Region: allantoinase; TIGR03178 1179773018300 active site 1179773018301 Glycerate kinase family; Region: Gly_kinase; cl00841 1179773018302 putative OHCU decarboxylase; Provisional; Region: PRK13798 1179773018303 urate oxidase; Region: urate_oxi; TIGR03383 1179773018304 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1179773018305 active site 1179773018306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773018307 binding surface 1179773018308 TPR motif; other site 1179773018309 CHAT domain; Region: CHAT; cl17868 1179773018310 malate synthase A; Region: malate_syn_A; TIGR01344 1179773018311 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1179773018312 active site 1179773018313 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1179773018314 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773018315 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773018316 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773018317 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773018318 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773018319 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1179773018320 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1179773018321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1179773018322 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1179773018323 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 1179773018324 Na binding site [ion binding]; other site 1179773018325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773018326 Coenzyme A binding pocket [chemical binding]; other site 1179773018327 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773018328 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773018329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773018330 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773018331 putative acyl-acceptor binding pocket; other site 1179773018332 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1179773018333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773018334 Histidine kinase; Region: HisKA_3; pfam07730 1179773018335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773018336 ATP binding site [chemical binding]; other site 1179773018337 Mg2+ binding site [ion binding]; other site 1179773018338 G-X-G motif; other site 1179773018339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773018340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773018341 active site 1179773018342 phosphorylation site [posttranslational modification] 1179773018343 intermolecular recognition site; other site 1179773018344 dimerization interface [polypeptide binding]; other site 1179773018345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773018346 DNA binding residues [nucleotide binding] 1179773018347 dimerization interface [polypeptide binding]; other site 1179773018348 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1179773018349 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1179773018350 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1179773018351 Walker A/P-loop; other site 1179773018352 ATP binding site [chemical binding]; other site 1179773018353 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1179773018354 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1179773018355 ABC transporter signature motif; other site 1179773018356 Walker B; other site 1179773018357 D-loop; other site 1179773018358 H-loop/switch region; other site 1179773018359 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773018360 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1179773018361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773018362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773018363 DNA binding residues [nucleotide binding] 1179773018364 acylphosphatase; Provisional; Region: PRK14422 1179773018365 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1179773018366 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1179773018367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773018368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773018369 S-adenosylmethionine binding site [chemical binding]; other site 1179773018370 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1179773018371 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1179773018372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773018373 active site 1179773018374 phosphorylation site [posttranslational modification] 1179773018375 intermolecular recognition site; other site 1179773018376 dimerization interface [polypeptide binding]; other site 1179773018377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773018378 DNA binding site [nucleotide binding] 1179773018379 MarR family; Region: MarR; pfam01047 1179773018380 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1179773018381 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1179773018382 DNA binding site [nucleotide binding] 1179773018383 catalytic residue [active] 1179773018384 H2TH interface [polypeptide binding]; other site 1179773018385 putative catalytic residues [active] 1179773018386 turnover-facilitating residue; other site 1179773018387 intercalation triad [nucleotide binding]; other site 1179773018388 8OG recognition residue [nucleotide binding]; other site 1179773018389 putative reading head residues; other site 1179773018390 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1179773018391 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1179773018392 ribonuclease III; Reviewed; Region: rnc; PRK00102 1179773018393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1179773018394 dimerization interface [polypeptide binding]; other site 1179773018395 active site 1179773018396 metal binding site [ion binding]; metal-binding site 1179773018397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1179773018398 dsRNA binding site [nucleotide binding]; other site 1179773018399 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1179773018400 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1179773018401 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1179773018402 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1179773018403 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1179773018404 active site 1179773018405 barstar interaction site; other site 1179773018406 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1179773018407 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1179773018408 active site 1179773018409 (T/H)XGH motif; other site 1179773018410 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1179773018411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773018412 S-adenosylmethionine binding site [chemical binding]; other site 1179773018413 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773018414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773018415 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773018416 active site 1179773018417 Walker A/P-loop; other site 1179773018418 ATP binding site [chemical binding]; other site 1179773018419 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773018420 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773018421 structural tetrad; other site 1179773018422 classical (c) SDRs; Region: SDR_c; cd05233 1179773018423 short chain dehydrogenase; Provisional; Region: PRK07577 1179773018424 NAD(P) binding site [chemical binding]; other site 1179773018425 active site 1179773018426 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1179773018427 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1179773018428 pyruvate carboxylase; Reviewed; Region: PRK12999 1179773018429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773018430 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773018431 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773018432 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1179773018433 active site 1179773018434 catalytic residues [active] 1179773018435 metal binding site [ion binding]; metal-binding site 1179773018436 homodimer binding site [polypeptide binding]; other site 1179773018437 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773018438 carboxyltransferase (CT) interaction site; other site 1179773018439 biotinylation site [posttranslational modification]; other site 1179773018440 hypothetical protein; Provisional; Region: PRK11281 1179773018441 AAA domain; Region: AAA_13; pfam13166 1179773018442 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1179773018443 generic binding surface II; other site 1179773018444 ssDNA binding site; other site 1179773018445 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1179773018446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1179773018447 putative Mg++ binding site [ion binding]; other site 1179773018448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1179773018449 nucleotide binding region [chemical binding]; other site 1179773018450 ATP-binding site [chemical binding]; other site 1179773018451 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1179773018452 DAK2 domain; Region: Dak2; pfam02734 1179773018453 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1179773018454 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1179773018455 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773018456 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773018457 thiamine monophosphate kinase; Provisional; Region: PRK05731 1179773018458 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1179773018459 ATP binding site [chemical binding]; other site 1179773018460 dimerization interface [polypeptide binding]; other site 1179773018461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773018462 Coenzyme A binding pocket [chemical binding]; other site 1179773018463 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1179773018464 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1179773018465 trimer interface [polypeptide binding]; other site 1179773018466 putative metal binding site [ion binding]; other site 1179773018467 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1179773018468 ligand binding site [chemical binding]; other site 1179773018469 active site 1179773018470 UGI interface [polypeptide binding]; other site 1179773018471 catalytic site [active] 1179773018472 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1179773018473 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773018474 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1179773018475 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773018476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773018477 DNA-binding site [nucleotide binding]; DNA binding site 1179773018478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773018479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773018480 homodimer interface [polypeptide binding]; other site 1179773018481 catalytic residue [active] 1179773018482 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1179773018483 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1179773018484 cystathionine gamma-lyase; Validated; Region: PRK07582 1179773018485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773018486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773018487 catalytic residue [active] 1179773018488 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1179773018489 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1179773018490 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1179773018491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773018492 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773018493 putative acyl-acceptor binding pocket; other site 1179773018494 Guanylyl transferase CofC like; Region: CofC; cl17472 1179773018495 polyphosphate kinase; Provisional; Region: PRK05443 1179773018496 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1179773018497 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1179773018498 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1179773018499 putative domain interface [polypeptide binding]; other site 1179773018500 putative active site [active] 1179773018501 catalytic site [active] 1179773018502 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1179773018503 putative active site [active] 1179773018504 catalytic site [active] 1179773018505 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1179773018506 active site 1179773018507 Ap6A binding site [chemical binding]; other site 1179773018508 nudix motif; other site 1179773018509 metal binding site [ion binding]; metal-binding site 1179773018510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773018511 catalytic core [active] 1179773018512 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1179773018513 IHF - DNA interface [nucleotide binding]; other site 1179773018514 IHF dimer interface [polypeptide binding]; other site 1179773018515 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1179773018516 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1179773018517 substrate binding site [chemical binding]; other site 1179773018518 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1179773018519 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1179773018520 substrate binding site [chemical binding]; other site 1179773018521 ligand binding site [chemical binding]; other site 1179773018522 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773018523 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773018524 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773018525 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1179773018526 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1179773018527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773018528 motif II; other site 1179773018529 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1179773018530 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1179773018531 HIGH motif; other site 1179773018532 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1179773018533 active site 1179773018534 KMSKS motif; other site 1179773018535 hypothetical protein; Provisional; Region: PRK06185 1179773018536 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1179773018537 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1179773018538 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1179773018539 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1179773018540 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1179773018541 active site 1179773018542 catalytic residues [active] 1179773018543 metal binding site [ion binding]; metal-binding site 1179773018544 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1179773018545 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1179773018546 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1179773018547 putative ligand binding residues [chemical binding]; other site 1179773018548 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1179773018549 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1179773018550 Walker A/P-loop; other site 1179773018551 ATP binding site [chemical binding]; other site 1179773018552 Q-loop/lid; other site 1179773018553 ABC transporter signature motif; other site 1179773018554 Walker B; other site 1179773018555 D-loop; other site 1179773018556 H-loop/switch region; other site 1179773018557 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1179773018558 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1179773018559 dimer interface [polypeptide binding]; other site 1179773018560 putative PBP binding regions; other site 1179773018561 ABC-ATPase subunit interface; other site 1179773018562 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1179773018563 tartrate dehydrogenase; Region: TTC; TIGR02089 1179773018564 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1179773018565 putative active site [active] 1179773018566 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1179773018567 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1179773018568 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1179773018569 ligand binding site [chemical binding]; other site 1179773018570 NAD binding site [chemical binding]; other site 1179773018571 dimerization interface [polypeptide binding]; other site 1179773018572 catalytic site [active] 1179773018573 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1179773018574 putative L-serine binding site [chemical binding]; other site 1179773018575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773018576 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773018577 hypothetical protein; Provisional; Region: PRK07236 1179773018578 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1179773018579 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773018580 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1179773018581 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1179773018582 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1179773018583 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1179773018584 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1179773018585 putative valine binding site [chemical binding]; other site 1179773018586 dimer interface [polypeptide binding]; other site 1179773018587 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1179773018588 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1179773018589 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1179773018590 PYR/PP interface [polypeptide binding]; other site 1179773018591 dimer interface [polypeptide binding]; other site 1179773018592 TPP binding site [chemical binding]; other site 1179773018593 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1179773018594 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1179773018595 TPP-binding site [chemical binding]; other site 1179773018596 dimer interface [polypeptide binding]; other site 1179773018597 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1179773018598 Vitamin K epoxide reductase family in archaea and some bacteria; Region: VKOR_arc; cd12918 1179773018599 putative active site [active] 1179773018600 redox center [active] 1179773018601 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1179773018602 DoxX; Region: DoxX; pfam07681 1179773018603 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1179773018604 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1179773018605 putative ligand binding site [chemical binding]; other site 1179773018606 putative NAD binding site [chemical binding]; other site 1179773018607 catalytic site [active] 1179773018608 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773018609 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1179773018610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773018611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773018612 binding surface 1179773018613 TPR motif; other site 1179773018614 CHAT domain; Region: CHAT; cl17868 1179773018615 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1179773018616 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1179773018617 GatB domain; Region: GatB_Yqey; smart00845 1179773018618 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1179773018619 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1179773018620 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1179773018621 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1179773018622 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1179773018623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773018624 Cupin; Region: Cupin_6; pfam12852 1179773018625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1179773018626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773018627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773018628 dimerization interface [polypeptide binding]; other site 1179773018629 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1179773018630 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1179773018631 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1179773018632 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1179773018633 L-aspartate oxidase; Provisional; Region: PRK06175 1179773018634 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1179773018635 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1179773018636 putative Iron-sulfur protein interface [polypeptide binding]; other site 1179773018637 proximal heme binding site [chemical binding]; other site 1179773018638 distal heme binding site [chemical binding]; other site 1179773018639 putative dimer interface [polypeptide binding]; other site 1179773018640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773018641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773018642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1179773018643 dimerization interface [polypeptide binding]; other site 1179773018644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773018645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773018646 Coenzyme A binding pocket [chemical binding]; other site 1179773018647 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1179773018648 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1179773018649 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1179773018650 Cellulose binding domain; Region: CBM_2; pfam00553 1179773018651 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1179773018652 active site 1179773018653 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1179773018654 CoenzymeA binding site [chemical binding]; other site 1179773018655 subunit interaction site [polypeptide binding]; other site 1179773018656 PHB binding site; other site 1179773018657 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773018658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773018659 catalytic residue [active] 1179773018660 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1179773018661 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1179773018662 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1179773018663 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1179773018664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773018665 catalytic residue [active] 1179773018666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773018667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773018668 putative substrate translocation pore; other site 1179773018669 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1179773018670 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773018671 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1179773018672 putative acyl-acceptor binding pocket; other site 1179773018673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1179773018674 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1179773018675 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1179773018676 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1179773018677 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1179773018678 Ligand binding site [chemical binding]; other site 1179773018679 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1179773018680 EDD domain protein, DegV family; Region: DegV; TIGR00762 1179773018681 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1179773018682 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1179773018683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773018684 S-adenosylmethionine binding site [chemical binding]; other site 1179773018685 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1179773018686 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1179773018687 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1179773018688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773018689 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773018690 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1179773018691 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1179773018692 putative NAD(P) binding site [chemical binding]; other site 1179773018693 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773018694 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773018695 serine O-acetyltransferase; Region: cysE; TIGR01172 1179773018696 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1179773018697 trimer interface [polypeptide binding]; other site 1179773018698 active site 1179773018699 substrate binding site [chemical binding]; other site 1179773018700 CoA binding site [chemical binding]; other site 1179773018701 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773018702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773018703 Coenzyme A binding pocket [chemical binding]; other site 1179773018704 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1179773018705 active site 1179773018706 tetramer interface [polypeptide binding]; other site 1179773018707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1179773018708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773018709 S-adenosylmethionine binding site [chemical binding]; other site 1179773018710 enoyl-CoA hydratase; Provisional; Region: PRK05862 1179773018711 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773018712 substrate binding site [chemical binding]; other site 1179773018713 oxyanion hole (OAH) forming residues; other site 1179773018714 trimer interface [polypeptide binding]; other site 1179773018715 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1179773018716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773018717 Walker A/P-loop; other site 1179773018718 ATP binding site [chemical binding]; other site 1179773018719 ABC transporter signature motif; other site 1179773018720 Walker B; other site 1179773018721 D-loop; other site 1179773018722 H-loop/switch region; other site 1179773018723 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1179773018724 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1179773018725 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1179773018726 active site 1179773018727 catalytic site [active] 1179773018728 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1179773018729 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1179773018730 active site residue [active] 1179773018731 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1179773018732 putative homodimer interface [polypeptide binding]; other site 1179773018733 putative active site pocket [active] 1179773018734 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1179773018735 NACHT domain; Region: NACHT; pfam05729 1179773018736 AAA domain; Region: AAA_14; pfam13173 1179773018737 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1179773018738 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1179773018739 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1179773018740 active site 1179773018741 homodimer interface [polypeptide binding]; other site 1179773018742 catalytic site [active] 1179773018743 acceptor binding site [chemical binding]; other site 1179773018744 trehalose synthase; Region: treS_nterm; TIGR02456 1179773018745 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1179773018746 active site 1179773018747 catalytic site [active] 1179773018748 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1179773018749 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1179773018750 glycogen branching enzyme; Provisional; Region: PRK05402 1179773018751 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1179773018752 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1179773018753 active site 1179773018754 catalytic site [active] 1179773018755 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1179773018756 translocation protein TolB; Provisional; Region: tolB; PRK02889 1179773018757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773018758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773018759 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1179773018760 sugar binding site [chemical binding]; other site 1179773018761 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773018762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1179773018763 active site 1179773018764 metal binding site [ion binding]; metal-binding site 1179773018765 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773018766 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773018767 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1179773018768 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773018769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773018770 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1179773018771 Domain of unknown function DUF77; Region: DUF77; pfam01910 1179773018772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1179773018773 MarR family; Region: MarR; pfam01047 1179773018774 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773018775 active site 1179773018776 ATP binding site [chemical binding]; other site 1179773018777 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773018778 substrate binding site [chemical binding]; other site 1179773018779 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1179773018780 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773018781 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773018782 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773018783 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773018784 Walker A/P-loop; other site 1179773018785 ATP binding site [chemical binding]; other site 1179773018786 Q-loop/lid; other site 1179773018787 ABC transporter signature motif; other site 1179773018788 Walker B; other site 1179773018789 D-loop; other site 1179773018790 H-loop/switch region; other site 1179773018791 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1179773018792 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1179773018793 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1179773018794 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1179773018795 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773018796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773018797 DNA binding site [nucleotide binding] 1179773018798 domain linker motif; other site 1179773018799 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773018800 dimerization interface [polypeptide binding]; other site 1179773018801 ligand binding site [chemical binding]; other site 1179773018802 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1179773018803 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1179773018804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773018805 Walker A/P-loop; other site 1179773018806 ATP binding site [chemical binding]; other site 1179773018807 Q-loop/lid; other site 1179773018808 ABC transporter signature motif; other site 1179773018809 Walker B; other site 1179773018810 D-loop; other site 1179773018811 H-loop/switch region; other site 1179773018812 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1179773018813 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773018814 TM-ABC transporter signature motif; other site 1179773018815 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1179773018816 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1179773018817 putative ligand binding site [chemical binding]; other site 1179773018818 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773018819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773018820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773018821 active site 1179773018822 phosphorylation site [posttranslational modification] 1179773018823 intermolecular recognition site; other site 1179773018824 dimerization interface [polypeptide binding]; other site 1179773018825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773018826 DNA binding residues [nucleotide binding] 1179773018827 dimerization interface [polypeptide binding]; other site 1179773018828 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773018829 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1179773018830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1179773018831 GAF domain; Region: GAF_2; pfam13185 1179773018832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773018833 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773018834 ATP binding site [chemical binding]; other site 1179773018835 G-X-G motif; other site 1179773018836 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1179773018837 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1179773018838 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1179773018839 Walker A; other site 1179773018840 putative acyltransferase; Provisional; Region: PRK05790 1179773018841 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773018842 dimer interface [polypeptide binding]; other site 1179773018843 active site 1179773018844 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1179773018845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773018846 dimer interface [polypeptide binding]; other site 1179773018847 substrate binding site [chemical binding]; other site 1179773018848 metal binding site [ion binding]; metal-binding site 1179773018849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773018850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773018851 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773018852 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1179773018853 NAD(P) binding site [chemical binding]; other site 1179773018854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773018855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773018856 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773018857 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773018858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773018859 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1179773018860 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1179773018861 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773018862 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773018863 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1179773018864 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1179773018865 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1179773018866 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1179773018867 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1179773018868 dimerization domain swap beta strand [polypeptide binding]; other site 1179773018869 regulatory protein interface [polypeptide binding]; other site 1179773018870 active site 1179773018871 regulatory phosphorylation site [posttranslational modification]; other site 1179773018872 DAK2 domain; Region: Dak2; cl03685 1179773018873 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1179773018874 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1179773018875 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773018876 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1179773018877 NAD(P) binding site [chemical binding]; other site 1179773018878 catalytic residues [active] 1179773018879 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1179773018880 Na binding site [ion binding]; other site 1179773018881 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1179773018882 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1179773018883 hypothetical protein; Provisional; Region: PRK03298 1179773018884 amino acid transporter; Region: 2A0306; TIGR00909 1179773018885 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1179773018886 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1179773018887 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1179773018888 dimer interface [polypeptide binding]; other site 1179773018889 ADP-ribose binding site [chemical binding]; other site 1179773018890 active site 1179773018891 nudix motif; other site 1179773018892 metal binding site [ion binding]; metal-binding site 1179773018893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773018894 enoyl-CoA hydratase; Validated; Region: PRK08139 1179773018895 substrate binding site [chemical binding]; other site 1179773018896 oxyanion hole (OAH) forming residues; other site 1179773018897 trimer interface [polypeptide binding]; other site 1179773018898 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1179773018899 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1179773018900 conserved cys residue [active] 1179773018901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773018902 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1179773018903 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773018904 catalytic triad [active] 1179773018905 conserved cis-peptide bond; other site 1179773018906 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1179773018907 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1179773018908 B12 binding site [chemical binding]; other site 1179773018909 cobalt ligand [ion binding]; other site 1179773018910 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1179773018911 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1179773018912 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1179773018913 hinge; other site 1179773018914 active site 1179773018915 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1179773018916 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1179773018917 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1179773018918 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1179773018919 gamma subunit interface [polypeptide binding]; other site 1179773018920 epsilon subunit interface [polypeptide binding]; other site 1179773018921 LBP interface [polypeptide binding]; other site 1179773018922 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773018923 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1179773018924 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773018925 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1179773018926 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1179773018927 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1179773018928 alpha subunit interaction interface [polypeptide binding]; other site 1179773018929 Walker A motif; other site 1179773018930 ATP binding site [chemical binding]; other site 1179773018931 Walker B motif; other site 1179773018932 inhibitor binding site; inhibition site 1179773018933 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1179773018934 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1179773018935 core domain interface [polypeptide binding]; other site 1179773018936 delta subunit interface [polypeptide binding]; other site 1179773018937 epsilon subunit interface [polypeptide binding]; other site 1179773018938 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1179773018939 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1179773018940 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1179773018941 beta subunit interaction interface [polypeptide binding]; other site 1179773018942 Walker A motif; other site 1179773018943 ATP binding site [chemical binding]; other site 1179773018944 Walker B motif; other site 1179773018945 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1179773018946 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1179773018947 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1179773018948 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1179773018949 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1179773018950 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1179773018951 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1179773018952 Mg++ binding site [ion binding]; other site 1179773018953 putative catalytic motif [active] 1179773018954 substrate binding site [chemical binding]; other site 1179773018955 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1179773018956 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1179773018957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773018958 S-adenosylmethionine binding site [chemical binding]; other site 1179773018959 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1179773018960 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1179773018961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773018962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773018963 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1179773018964 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1179773018965 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1179773018966 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1179773018967 RF-1 domain; Region: RF-1; pfam00472 1179773018968 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1179773018969 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1179773018970 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1179773018971 transcription termination factor Rho; Provisional; Region: PRK12608 1179773018972 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1179773018973 RNA binding site [nucleotide binding]; other site 1179773018974 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1179773018975 multimer interface [polypeptide binding]; other site 1179773018976 Walker A motif; other site 1179773018977 ATP binding site [chemical binding]; other site 1179773018978 Walker B motif; other site 1179773018979 homoserine kinase; Provisional; Region: PRK01212 1179773018980 threonine synthase; Reviewed; Region: PRK06721 1179773018981 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1179773018982 homodimer interface [polypeptide binding]; other site 1179773018983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773018984 catalytic residue [active] 1179773018985 homoserine dehydrogenase; Provisional; Region: PRK06349 1179773018986 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1179773018987 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1179773018988 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1179773018989 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1179773018990 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1179773018991 active site 1179773018992 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773018993 substrate binding site [chemical binding]; other site 1179773018994 catalytic residues [active] 1179773018995 dimer interface [polypeptide binding]; other site 1179773018996 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1179773018997 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1179773018998 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1179773018999 active site 1179773019000 HIGH motif; other site 1179773019001 KMSK motif region; other site 1179773019002 tRNA binding surface [nucleotide binding]; other site 1179773019003 DALR anticodon binding domain; Region: DALR_1; smart00836 1179773019004 anticodon binding site; other site 1179773019005 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1179773019006 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1179773019007 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1179773019008 Cytochrome P450; Region: p450; pfam00067 1179773019009 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773019010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773019011 S-adenosylmethionine binding site [chemical binding]; other site 1179773019012 PAS domain S-box; Region: sensory_box; TIGR00229 1179773019013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773019014 putative active site [active] 1179773019015 heme pocket [chemical binding]; other site 1179773019016 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773019017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773019018 metal binding site [ion binding]; metal-binding site 1179773019019 active site 1179773019020 I-site; other site 1179773019021 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773019022 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1179773019023 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1179773019024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773019025 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1179773019026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773019027 putative substrate translocation pore; other site 1179773019028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773019029 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773019030 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773019031 calcium binding site 2 [ion binding]; other site 1179773019032 active site 1179773019033 catalytic triad [active] 1179773019034 calcium binding site 1 [ion binding]; other site 1179773019035 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1179773019036 Putative Ig domain; Region: He_PIG; pfam05345 1179773019037 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773019038 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1179773019039 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773019040 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1179773019041 mismatch recognition site; other site 1179773019042 additional DNA contacts [nucleotide binding]; other site 1179773019043 active site 1179773019044 zinc binding site [ion binding]; other site 1179773019045 DNA intercalation site [nucleotide binding]; other site 1179773019046 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1179773019047 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773019048 cofactor binding site; other site 1179773019049 DNA binding site [nucleotide binding] 1179773019050 substrate interaction site [chemical binding]; other site 1179773019051 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1179773019052 Z1 domain; Region: Z1; pfam10593 1179773019053 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1179773019054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773019055 ATP binding site [chemical binding]; other site 1179773019056 Mg2+ binding site [ion binding]; other site 1179773019057 G-X-G motif; other site 1179773019058 short chain dehydrogenase; Validated; Region: PRK05855 1179773019059 classical (c) SDRs; Region: SDR_c; cd05233 1179773019060 NAD(P) binding site [chemical binding]; other site 1179773019061 active site 1179773019062 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1179773019063 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1179773019064 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773019065 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773019066 TIGR03086 family protein; Region: TIGR03086 1179773019067 Helix-turn-helix domain; Region: HTH_28; pfam13518 1179773019068 Winged helix-turn helix; Region: HTH_29; pfam13551 1179773019069 Homeodomain-like domain; Region: HTH_32; pfam13565 1179773019070 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773019071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1179773019072 Homeodomain-like domain; Region: HTH_23; cl17451 1179773019073 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1179773019074 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1179773019075 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1179773019076 MarR family; Region: MarR_2; pfam12802 1179773019077 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773019078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773019079 nucleotide binding site [chemical binding]; other site 1179773019080 Endonuclease I; Region: Endonuclease_1; pfam04231 1179773019081 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1179773019082 DNA binding site [nucleotide binding] 1179773019083 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773019084 AAA ATPase domain; Region: AAA_16; pfam13191 1179773019085 AAA domain; Region: AAA_22; pfam13401 1179773019086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773019087 MarR family; Region: MarR_2; cl17246 1179773019088 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1179773019089 EamA-like transporter family; Region: EamA; pfam00892 1179773019090 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1179773019091 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1179773019092 NAD binding site [chemical binding]; other site 1179773019093 substrate binding site [chemical binding]; other site 1179773019094 putative active site [active] 1179773019095 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1179773019096 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1179773019097 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1179773019098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773019099 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773019100 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773019101 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773019102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773019103 putative DNA binding site [nucleotide binding]; other site 1179773019104 putative Zn2+ binding site [ion binding]; other site 1179773019105 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773019106 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773019107 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1179773019108 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1179773019109 nucleoside/Zn binding site; other site 1179773019110 dimer interface [polypeptide binding]; other site 1179773019111 catalytic motif [active] 1179773019112 EspG family; Region: ESX-1_EspG; pfam14011 1179773019113 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1179773019114 active site 1179773019115 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1179773019116 non-prolyl cis peptide bond; other site 1179773019117 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1179773019118 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 1179773019119 Predicted membrane protein [Function unknown]; Region: COG2259 1179773019120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1179773019121 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1179773019122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773019123 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1179773019124 DNA binding residues [nucleotide binding] 1179773019125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773019126 Coenzyme A binding pocket [chemical binding]; other site 1179773019127 Helix-turn-helix domain; Region: HTH_18; pfam12833 1179773019128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773019129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773019130 Walker A motif; other site 1179773019131 ATP binding site [chemical binding]; other site 1179773019132 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773019133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773019134 DNA binding residues [nucleotide binding] 1179773019135 dimerization interface [polypeptide binding]; other site 1179773019136 hypothetical protein; Provisional; Region: PRK06847 1179773019137 hypothetical protein; Provisional; Region: PRK07236 1179773019138 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1179773019139 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1179773019140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773019141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773019142 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1179773019143 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1179773019144 tetramer interface [polypeptide binding]; other site 1179773019145 active site 1179773019146 Mg2+/Mn2+ binding site [ion binding]; other site 1179773019147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773019148 putative DNA binding site [nucleotide binding]; other site 1179773019149 dimerization interface [polypeptide binding]; other site 1179773019150 putative Zn2+ binding site [ion binding]; other site 1179773019151 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1179773019152 active site 1179773019153 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1179773019154 non-specific DNA interactions [nucleotide binding]; other site 1179773019155 DNA binding site [nucleotide binding] 1179773019156 sequence specific DNA binding site [nucleotide binding]; other site 1179773019157 putative cAMP binding site [chemical binding]; other site 1179773019158 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773019159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773019160 Domain of unknown function (DUF336); Region: DUF336; cl01249 1179773019161 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773019162 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773019163 CBD_II domain; Region: CBD_II; smart00637 1179773019164 Glyco_18 domain; Region: Glyco_18; smart00636 1179773019165 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773019166 active site 1179773019167 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 1179773019168 putative active site [active] 1179773019169 Zn binding site [ion binding]; other site 1179773019170 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773019171 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1179773019172 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773019173 DNA binding residues [nucleotide binding] 1179773019174 drug binding residues [chemical binding]; other site 1179773019175 dimer interface [polypeptide binding]; other site 1179773019176 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1179773019177 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019178 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773019180 non-specific DNA binding site [nucleotide binding]; other site 1179773019181 salt bridge; other site 1179773019182 sequence-specific DNA binding site [nucleotide binding]; other site 1179773019183 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1179773019184 AAA domain; Region: AAA_30; pfam13604 1179773019185 Family description; Region: UvrD_C_2; pfam13538 1179773019186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773019187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773019188 active site 1179773019189 phosphorylation site [posttranslational modification] 1179773019190 intermolecular recognition site; other site 1179773019191 dimerization interface [polypeptide binding]; other site 1179773019192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773019193 DNA binding site [nucleotide binding] 1179773019194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773019195 dimerization interface [polypeptide binding]; other site 1179773019196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773019197 dimer interface [polypeptide binding]; other site 1179773019198 phosphorylation site [posttranslational modification] 1179773019199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773019200 ATP binding site [chemical binding]; other site 1179773019201 Mg2+ binding site [ion binding]; other site 1179773019202 G-X-G motif; other site 1179773019203 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1179773019204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773019205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773019206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773019207 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1179773019208 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1179773019209 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1179773019210 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773019211 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1179773019212 active site 1179773019213 catalytic residues [active] 1179773019214 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1179773019215 FAD binding domain; Region: FAD_binding_2; pfam00890 1179773019216 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773019217 AAA ATPase domain; Region: AAA_16; pfam13191 1179773019218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773019220 binding surface 1179773019221 TPR motif; other site 1179773019222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1179773019225 binding surface 1179773019226 TPR motif; other site 1179773019227 Capsid triplex subunit 2; Provisional; Region: PHA03260 1179773019228 EspG family; Region: ESX-1_EspG; pfam14011 1179773019229 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773019230 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1179773019231 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1179773019232 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1179773019233 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773019234 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1179773019235 Walker A/P-loop; other site 1179773019236 ATP binding site [chemical binding]; other site 1179773019237 Q-loop/lid; other site 1179773019238 ABC transporter signature motif; other site 1179773019239 Walker B; other site 1179773019240 D-loop; other site 1179773019241 H-loop/switch region; other site 1179773019242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773019243 dimer interface [polypeptide binding]; other site 1179773019244 conserved gate region; other site 1179773019245 putative PBP binding loops; other site 1179773019246 ABC-ATPase subunit interface; other site 1179773019247 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1179773019248 active site 1179773019249 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1179773019250 dimer interface [polypeptide binding]; other site 1179773019251 non-prolyl cis peptide bond; other site 1179773019252 insertion regions; other site 1179773019253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773019254 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773019255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773019256 substrate binding pocket [chemical binding]; other site 1179773019257 membrane-bound complex binding site; other site 1179773019258 hinge residues; other site 1179773019259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773019260 PAS domain; Region: PAS_9; pfam13426 1179773019261 putative active site [active] 1179773019262 heme pocket [chemical binding]; other site 1179773019263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773019264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773019265 metal binding site [ion binding]; metal-binding site 1179773019266 active site 1179773019267 I-site; other site 1179773019268 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773019269 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773019270 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019271 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019272 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1179773019273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773019274 S-adenosylmethionine binding site [chemical binding]; other site 1179773019275 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1179773019276 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773019277 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1179773019278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773019279 active site 1179773019280 enoyl-CoA hydratase; Provisional; Region: PRK06190 1179773019281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773019282 substrate binding site [chemical binding]; other site 1179773019283 oxyanion hole (OAH) forming residues; other site 1179773019284 trimer interface [polypeptide binding]; other site 1179773019285 Winged helix-turn helix; Region: HTH_29; pfam13551 1179773019286 Homeodomain-like domain; Region: HTH_32; pfam13565 1179773019287 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1179773019288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773019289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773019290 Nitronate monooxygenase; Region: NMO; pfam03060 1179773019291 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1179773019292 FMN binding site [chemical binding]; other site 1179773019293 substrate binding site [chemical binding]; other site 1179773019294 putative catalytic residue [active] 1179773019295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773019296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773019297 active site 1179773019298 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1179773019299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773019300 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1179773019301 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773019302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773019303 carboxyltransferase (CT) interaction site; other site 1179773019304 biotinylation site [posttranslational modification]; other site 1179773019305 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1179773019306 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773019307 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773019308 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773019309 active site 1179773019310 oxyanion hole [active] 1179773019311 catalytic triad [active] 1179773019312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773019313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773019314 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773019315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773019316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773019317 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1179773019318 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1179773019319 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1179773019320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773019321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773019322 active site 1179773019323 phosphorylation site [posttranslational modification] 1179773019324 intermolecular recognition site; other site 1179773019325 dimerization interface [polypeptide binding]; other site 1179773019326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773019327 DNA binding residues [nucleotide binding] 1179773019328 dimerization interface [polypeptide binding]; other site 1179773019329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773019330 Histidine kinase; Region: HisKA_3; pfam07730 1179773019331 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773019332 CBD_II domain; Region: CBD_II; smart00637 1179773019333 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773019334 Interdomain contacts; other site 1179773019335 Cytokine receptor motif; other site 1179773019336 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1179773019337 active site 1179773019338 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1179773019339 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1179773019340 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1179773019341 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1179773019342 homodimer interface [polypeptide binding]; other site 1179773019343 substrate-cofactor binding pocket; other site 1179773019344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773019345 catalytic residue [active] 1179773019346 putative oxidoreductase; Provisional; Region: PRK11579 1179773019347 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1179773019348 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1179773019349 FAD binding domain; Region: FAD_binding_3; pfam01494 1179773019350 hypothetical protein; Provisional; Region: PRK07236 1179773019351 metabolite-proton symporter; Region: 2A0106; TIGR00883 1179773019352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773019353 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773019354 active site 1179773019355 catalytic triad [active] 1179773019356 oxyanion hole [active] 1179773019357 Subtilisin inhibitor-like; Region: SSI; cl11594 1179773019358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773019359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1179773019360 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1179773019361 ABC1 family; Region: ABC1; pfam03109 1179773019362 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773019363 active site 1179773019364 ATP binding site [chemical binding]; other site 1179773019365 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1179773019366 catalytic residues [active] 1179773019367 dimer interface [polypeptide binding]; other site 1179773019368 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1179773019369 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1179773019370 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1179773019371 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1179773019372 lipoyl attachment site [posttranslational modification]; other site 1179773019373 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1179773019374 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1179773019375 hexamer interface [polypeptide binding]; other site 1179773019376 ligand binding site [chemical binding]; other site 1179773019377 putative active site [active] 1179773019378 NAD(P) binding site [chemical binding]; other site 1179773019379 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773019380 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1179773019381 Walker A/P-loop; other site 1179773019382 ATP binding site [chemical binding]; other site 1179773019383 Q-loop/lid; other site 1179773019384 ABC transporter signature motif; other site 1179773019385 Walker B; other site 1179773019386 D-loop; other site 1179773019387 H-loop/switch region; other site 1179773019388 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1179773019389 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1179773019390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1179773019391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773019392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773019393 Walker A/P-loop; other site 1179773019394 ATP binding site [chemical binding]; other site 1179773019395 Q-loop/lid; other site 1179773019396 ABC transporter signature motif; other site 1179773019397 Walker B; other site 1179773019398 D-loop; other site 1179773019399 H-loop/switch region; other site 1179773019400 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1179773019401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1179773019402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773019403 Walker A/P-loop; other site 1179773019404 ATP binding site [chemical binding]; other site 1179773019405 Q-loop/lid; other site 1179773019406 ABC transporter signature motif; other site 1179773019407 Walker B; other site 1179773019408 D-loop; other site 1179773019409 H-loop/switch region; other site 1179773019410 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1179773019411 putative hydrophobic ligand binding site [chemical binding]; other site 1179773019412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773019413 dimerization interface [polypeptide binding]; other site 1179773019414 putative DNA binding site [nucleotide binding]; other site 1179773019415 putative Zn2+ binding site [ion binding]; other site 1179773019416 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1179773019417 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1179773019418 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1179773019419 TPP-binding site [chemical binding]; other site 1179773019420 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1179773019421 dimer interface [polypeptide binding]; other site 1179773019422 PYR/PP interface [polypeptide binding]; other site 1179773019423 TPP binding site [chemical binding]; other site 1179773019424 O-Antigen ligase; Region: Wzy_C; cl04850 1179773019425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1179773019426 AAA ATPase domain; Region: AAA_16; pfam13191 1179773019427 NACHT domain; Region: NACHT; pfam05729 1179773019428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019431 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773019432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019433 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773019434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773019435 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1179773019436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773019437 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1179773019438 Walker A motif; other site 1179773019439 ATP binding site [chemical binding]; other site 1179773019440 Walker B motif; other site 1179773019441 arginine finger; other site 1179773019442 imidazolonepropionase; Provisional; Region: PRK14085 1179773019443 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1179773019444 active site 1179773019445 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773019446 Amidohydrolase; Region: Amidohydro_4; pfam13147 1179773019447 active site 1179773019448 allantoate amidohydrolase; Reviewed; Region: PRK09290 1179773019449 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1179773019450 active site 1179773019451 metal binding site [ion binding]; metal-binding site 1179773019452 dimer interface [polypeptide binding]; other site 1179773019453 urocanate hydratase; Provisional; Region: PRK05414 1179773019454 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1179773019455 active sites [active] 1179773019456 tetramer interface [polypeptide binding]; other site 1179773019457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1179773019458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773019459 putative DNA binding site [nucleotide binding]; other site 1179773019460 putative Zn2+ binding site [ion binding]; other site 1179773019461 Bacterial transcriptional regulator; Region: IclR; pfam01614 1179773019462 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1179773019463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773019464 ABC-ATPase subunit interface; other site 1179773019465 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1179773019466 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1179773019467 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1179773019468 Walker A/P-loop; other site 1179773019469 ATP binding site [chemical binding]; other site 1179773019470 Q-loop/lid; other site 1179773019471 ABC transporter signature motif; other site 1179773019472 Walker B; other site 1179773019473 D-loop; other site 1179773019474 H-loop/switch region; other site 1179773019475 Protein of unknown function DUF43; Region: DUF43; pfam01861 1179773019476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773019477 PAS fold; Region: PAS_3; pfam08447 1179773019478 putative active site [active] 1179773019479 heme pocket [chemical binding]; other site 1179773019480 PAS domain; Region: PAS_9; pfam13426 1179773019481 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1179773019482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773019483 putative active site [active] 1179773019484 heme pocket [chemical binding]; other site 1179773019485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773019486 putative active site [active] 1179773019487 heme pocket [chemical binding]; other site 1179773019488 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773019489 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773019490 metal binding site [ion binding]; metal-binding site 1179773019491 active site 1179773019492 I-site; other site 1179773019493 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773019494 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1179773019495 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1179773019496 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1179773019497 NAD(P) binding pocket [chemical binding]; other site 1179773019498 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1179773019499 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1179773019500 Catalytic site [active] 1179773019501 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 1179773019502 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1179773019503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773019504 DNA-binding site [nucleotide binding]; DNA binding site 1179773019505 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773019506 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773019507 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1179773019508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773019509 active site 1179773019510 DNA binding site [nucleotide binding] 1179773019511 Int/Topo IB signature motif; other site 1179773019512 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1179773019513 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773019514 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1179773019515 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1179773019516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773019517 catalytic core [active] 1179773019518 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773019519 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773019520 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1179773019521 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1179773019522 cleavage site 1179773019523 active site 1179773019524 substrate binding sites [chemical binding]; other site 1179773019525 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1179773019526 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1179773019527 Transcription factor WhiB; Region: Whib; pfam02467 1179773019528 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1179773019529 PAS fold; Region: PAS_4; pfam08448 1179773019530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1179773019531 Histidine kinase; Region: HisKA_2; pfam07568 1179773019532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773019533 ATP binding site [chemical binding]; other site 1179773019534 Mg2+ binding site [ion binding]; other site 1179773019535 G-X-G motif; other site 1179773019536 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1179773019537 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1179773019538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773019539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773019540 DNA binding residues [nucleotide binding] 1179773019541 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1179773019542 putative deacylase active site [active] 1179773019543 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773019544 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773019545 putative sugar binding sites [chemical binding]; other site 1179773019546 Q-X-W motif; other site 1179773019547 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1179773019548 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1179773019549 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1179773019550 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1179773019551 hinge; other site 1179773019552 active site 1179773019553 Predicted GTPases [General function prediction only]; Region: COG1162 1179773019554 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1179773019555 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1179773019556 GTP/Mg2+ binding site [chemical binding]; other site 1179773019557 G4 box; other site 1179773019558 G5 box; other site 1179773019559 G1 box; other site 1179773019560 Switch I region; other site 1179773019561 G2 box; other site 1179773019562 G3 box; other site 1179773019563 Switch II region; other site 1179773019564 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773019565 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1179773019566 NAD(P) binding site [chemical binding]; other site 1179773019567 catalytic residues [active] 1179773019568 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1179773019569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773019570 active site 1179773019571 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1179773019572 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1179773019573 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1179773019574 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773019575 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1179773019576 active site 1179773019577 substrate binding site [chemical binding]; other site 1179773019578 ATP binding site [chemical binding]; other site 1179773019579 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1179773019580 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1179773019581 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1179773019582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773019583 active site 1179773019584 motif I; other site 1179773019585 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1179773019586 motif II; other site 1179773019587 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1179773019588 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1179773019589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1179773019590 nucleotide binding region [chemical binding]; other site 1179773019591 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1179773019592 30S subunit binding site; other site 1179773019593 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1179773019594 lipoprotein LpqB; Provisional; Region: PRK13616 1179773019595 Sporulation and spore germination; Region: Germane; pfam10646 1179773019596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773019597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1179773019598 dimerization interface [polypeptide binding]; other site 1179773019599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773019600 dimer interface [polypeptide binding]; other site 1179773019601 phosphorylation site [posttranslational modification] 1179773019602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773019603 ATP binding site [chemical binding]; other site 1179773019604 Mg2+ binding site [ion binding]; other site 1179773019605 G-X-G motif; other site 1179773019606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773019607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773019608 active site 1179773019609 phosphorylation site [posttranslational modification] 1179773019610 intermolecular recognition site; other site 1179773019611 dimerization interface [polypeptide binding]; other site 1179773019612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773019613 DNA binding site [nucleotide binding] 1179773019614 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1179773019615 thymidylate kinase; Validated; Region: PRK07933 1179773019616 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1179773019617 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1179773019618 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1179773019619 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1179773019620 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1179773019621 homotetramer interface [polypeptide binding]; other site 1179773019622 ligand binding site [chemical binding]; other site 1179773019623 catalytic site [active] 1179773019624 NAD binding site [chemical binding]; other site 1179773019625 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773019626 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1179773019627 MutL protein; Region: MutL; pfam13941 1179773019628 amino acid transporter; Region: 2A0306; TIGR00909 1179773019629 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1179773019630 Cation efflux family; Region: Cation_efflux; pfam01545 1179773019631 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1179773019632 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1179773019633 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1179773019634 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1179773019635 Trm112p-like protein; Region: Trm112p; cl01066 1179773019636 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1179773019637 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1179773019638 active site 1179773019639 substrate binding site [chemical binding]; other site 1179773019640 metal binding site [ion binding]; metal-binding site 1179773019641 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1179773019642 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1179773019643 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1179773019644 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1179773019645 active site 1179773019646 Transcription factor WhiB; Region: Whib; pfam02467 1179773019647 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1179773019648 Peptidase family M50; Region: Peptidase_M50; pfam02163 1179773019649 active site 1179773019650 putative substrate binding region [chemical binding]; other site 1179773019651 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1179773019652 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1179773019653 dimer interface [polypeptide binding]; other site 1179773019654 phosphate binding site [ion binding]; other site 1179773019655 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1179773019656 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1179773019657 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1179773019658 putative FMN binding site [chemical binding]; other site 1179773019659 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1179773019660 nudix motif; other site 1179773019661 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1179773019662 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1179773019663 active site 1179773019664 Substrate binding site; other site 1179773019665 Mg++ binding site; other site 1179773019666 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1179773019667 putative trimer interface [polypeptide binding]; other site 1179773019668 putative CoA binding site [chemical binding]; other site 1179773019669 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1179773019670 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1179773019671 minor groove reading motif; other site 1179773019672 helix-hairpin-helix signature motif; other site 1179773019673 active site 1179773019674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773019675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773019676 active site 1179773019677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1179773019678 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1179773019679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773019680 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1179773019681 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773019682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773019683 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773019684 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1179773019685 Probable Catalytic site; other site 1179773019686 metal-binding site 1179773019687 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1179773019688 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1179773019689 Probable Catalytic site; other site 1179773019690 metal-binding site 1179773019691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1179773019692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773019693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773019694 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1179773019695 Helix-turn-helix domain; Region: HTH_31; pfam13560 1179773019696 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019697 Immunity protein Imm1; Region: Imm1; pfam14430 1179773019698 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1179773019699 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1179773019700 NADP binding site [chemical binding]; other site 1179773019701 active site 1179773019702 putative substrate binding site [chemical binding]; other site 1179773019703 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1179773019704 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1179773019705 NAD binding site [chemical binding]; other site 1179773019706 substrate binding site [chemical binding]; other site 1179773019707 homodimer interface [polypeptide binding]; other site 1179773019708 active site 1179773019709 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773019710 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1179773019711 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773019712 TIGR03089 family protein; Region: TIGR03089 1179773019713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773019714 dimerization interface [polypeptide binding]; other site 1179773019715 putative DNA binding site [nucleotide binding]; other site 1179773019716 putative Zn2+ binding site [ion binding]; other site 1179773019717 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1179773019718 putative hydrophobic ligand binding site [chemical binding]; other site 1179773019719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773019720 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1179773019721 FAD binding site [chemical binding]; other site 1179773019722 homotetramer interface [polypeptide binding]; other site 1179773019723 substrate binding pocket [chemical binding]; other site 1179773019724 catalytic base [active] 1179773019725 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1179773019726 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1179773019727 ATP-grasp domain; Region: ATP-grasp; pfam02222 1179773019728 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1179773019729 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1179773019730 Walker A/P-loop; other site 1179773019731 ATP binding site [chemical binding]; other site 1179773019732 Q-loop/lid; other site 1179773019733 ABC transporter signature motif; other site 1179773019734 Walker B; other site 1179773019735 D-loop; other site 1179773019736 H-loop/switch region; other site 1179773019737 Predicted transcriptional regulators [Transcription]; Region: COG1725 1179773019738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773019739 DNA-binding site [nucleotide binding]; DNA binding site 1179773019740 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773019741 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773019742 putative sugar binding sites [chemical binding]; other site 1179773019743 Q-X-W motif; other site 1179773019744 putative diguanylate cyclase; Provisional; Region: PRK09776 1179773019745 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773019746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773019747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773019748 DNA binding residues [nucleotide binding] 1179773019749 Putative zinc-finger; Region: zf-HC2; pfam13490 1179773019750 Predicted membrane protein [Function unknown]; Region: COG2246 1179773019751 GtrA-like protein; Region: GtrA; pfam04138 1179773019752 Predicted membrane protein [Function unknown]; Region: COG2246 1179773019753 GtrA-like protein; Region: GtrA; pfam04138 1179773019754 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1179773019755 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1179773019756 active site 1179773019757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773019758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773019759 active site 1179773019760 phosphorylation site [posttranslational modification] 1179773019761 intermolecular recognition site; other site 1179773019762 dimerization interface [polypeptide binding]; other site 1179773019763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773019764 DNA binding site [nucleotide binding] 1179773019765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773019766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773019767 ATP binding site [chemical binding]; other site 1179773019768 Mg2+ binding site [ion binding]; other site 1179773019769 G-X-G motif; other site 1179773019770 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1179773019771 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1179773019772 active site 1179773019773 catalytic residues [active] 1179773019774 metal binding site [ion binding]; metal-binding site 1179773019775 Bacterial PH domain; Region: DUF304; pfam03703 1179773019776 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1179773019777 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1179773019778 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1179773019779 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1179773019780 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1179773019781 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1179773019782 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1179773019783 Maf-like protein; Region: Maf; pfam02545 1179773019784 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1179773019785 active site 1179773019786 dimer interface [polypeptide binding]; other site 1179773019787 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1179773019788 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1179773019789 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1179773019790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1179773019791 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1179773019792 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1179773019793 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1179773019794 carboxyltransferase (CT) interaction site; other site 1179773019795 biotinylation site [posttranslational modification]; other site 1179773019796 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773019797 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1179773019798 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1179773019799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1179773019800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773019801 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1179773019802 Fanconi anemia group F protein (FANCF); Region: FANCF; pfam11107 1179773019803 PPE family; Region: PPE; pfam00823 1179773019804 EspG family; Region: ESX-1_EspG; pfam14011 1179773019805 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1179773019806 putative active site pocket [active] 1179773019807 dimerization interface [polypeptide binding]; other site 1179773019808 putative catalytic residue [active] 1179773019809 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1179773019810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773019811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773019812 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1179773019813 glycerol kinase; Provisional; Region: glpK; PRK00047 1179773019814 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1179773019815 N- and C-terminal domain interface [polypeptide binding]; other site 1179773019816 active site 1179773019817 MgATP binding site [chemical binding]; other site 1179773019818 catalytic site [active] 1179773019819 metal binding site [ion binding]; metal-binding site 1179773019820 putative homotetramer interface [polypeptide binding]; other site 1179773019821 glycerol binding site [chemical binding]; other site 1179773019822 homodimer interface [polypeptide binding]; other site 1179773019823 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1179773019824 amphipathic channel; other site 1179773019825 Asn-Pro-Ala signature motifs; other site 1179773019826 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1179773019827 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1179773019828 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1179773019829 metal binding site [ion binding]; metal-binding site 1179773019830 putative dimer interface [polypeptide binding]; other site 1179773019831 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1179773019832 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1179773019833 metal binding site [ion binding]; metal-binding site 1179773019834 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1179773019835 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1179773019836 Walker A; other site 1179773019837 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1179773019838 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1179773019839 active site 1179773019840 substrate binding site [chemical binding]; other site 1179773019841 coenzyme B12 binding site [chemical binding]; other site 1179773019842 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1179773019843 B12 binding site [chemical binding]; other site 1179773019844 cobalt ligand [ion binding]; other site 1179773019845 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1179773019846 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1179773019847 heterodimer interface [polypeptide binding]; other site 1179773019848 substrate interaction site [chemical binding]; other site 1179773019849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1179773019850 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773019851 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773019852 active site 1179773019853 ATP binding site [chemical binding]; other site 1179773019854 substrate binding site [chemical binding]; other site 1179773019855 activation loop (A-loop); other site 1179773019856 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1179773019857 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1179773019858 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1179773019859 active site 1179773019860 substrate binding site [chemical binding]; other site 1179773019861 metal binding site [ion binding]; metal-binding site 1179773019862 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1179773019863 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1179773019864 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1179773019865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773019866 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773019867 active site 1179773019868 catalytic tetrad [active] 1179773019869 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773019870 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1179773019871 DNA binding residues [nucleotide binding] 1179773019872 putative dimer interface [polypeptide binding]; other site 1179773019873 Fic/DOC family; Region: Fic; cl00960 1179773019874 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1179773019875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773019876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773019877 WHG domain; Region: WHG; pfam13305 1179773019878 Glyco_18 domain; Region: Glyco_18; smart00636 1179773019879 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773019880 active site 1179773019881 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773019882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773019883 NAD(P) binding site [chemical binding]; other site 1179773019884 active site 1179773019885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1179773019886 active site 1179773019887 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773019888 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773019889 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1179773019890 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1179773019891 active site 1179773019892 metal binding site [ion binding]; metal-binding site 1179773019893 AAA domain; Region: AAA_22; pfam13401 1179773019894 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1179773019895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1179773019896 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773019897 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773019898 structural tetrad; other site 1179773019899 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1179773019900 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773019901 structural tetrad; other site 1179773019902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773019903 non-specific DNA binding site [nucleotide binding]; other site 1179773019904 salt bridge; other site 1179773019905 sequence-specific DNA binding site [nucleotide binding]; other site 1179773019906 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019907 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019908 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773019909 Caspase domain; Region: Peptidase_C14; pfam00656 1179773019910 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1179773019911 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1179773019912 structural tetrad; other site 1179773019913 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773019914 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1179773019915 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1179773019916 intersubunit interface [polypeptide binding]; other site 1179773019917 active site 1179773019918 catalytic residue [active] 1179773019919 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773019920 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773019921 NAD(P) binding site [chemical binding]; other site 1179773019922 catalytic residues [active] 1179773019923 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773019924 NAD(P) binding site [chemical binding]; other site 1179773019925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1179773019926 Bacterial SH3 domain; Region: SH3_5; pfam08460 1179773019927 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773019928 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773019929 ATP binding site [chemical binding]; other site 1179773019930 substrate binding site [chemical binding]; other site 1179773019931 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1179773019932 Fic/DOC family; Region: Fic; cl00960 1179773019933 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1179773019934 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1179773019935 FIC domain binding interface [polypeptide binding]; other site 1179773019936 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1179773019937 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1179773019938 NlpC/P60 family; Region: NLPC_P60; pfam00877 1179773019939 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773019940 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1179773019941 adenosine deaminase; Provisional; Region: PRK09358 1179773019942 active site 1179773019943 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 1179773019944 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1179773019945 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1179773019946 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1179773019947 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1179773019948 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1179773019949 active site 1179773019950 catalytic motif [active] 1179773019951 Zn binding site [ion binding]; other site 1179773019952 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1179773019953 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773019954 TM-ABC transporter signature motif; other site 1179773019955 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773019956 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1179773019957 TM-ABC transporter signature motif; other site 1179773019958 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1179773019959 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1179773019960 Walker A/P-loop; other site 1179773019961 ATP binding site [chemical binding]; other site 1179773019962 Q-loop/lid; other site 1179773019963 ABC transporter signature motif; other site 1179773019964 Walker B; other site 1179773019965 D-loop; other site 1179773019966 H-loop/switch region; other site 1179773019967 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1179773019968 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1179773019969 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1179773019970 ligand binding site [chemical binding]; other site 1179773019971 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1179773019972 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1179773019973 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1179773019974 putative Iron-sulfur protein interface [polypeptide binding]; other site 1179773019975 putative proximal heme binding site [chemical binding]; other site 1179773019976 putative SdhD-like interface [polypeptide binding]; other site 1179773019977 putative distal heme binding site [chemical binding]; other site 1179773019978 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1179773019979 putative Iron-sulfur protein interface [polypeptide binding]; other site 1179773019980 putative proximal heme binding site [chemical binding]; other site 1179773019981 putative SdhC-like subunit interface [polypeptide binding]; other site 1179773019982 putative distal heme binding site [chemical binding]; other site 1179773019983 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1179773019984 L-aspartate oxidase; Provisional; Region: PRK06175 1179773019985 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1179773019986 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1179773019987 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1179773019988 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1179773019989 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1179773019990 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1179773019991 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1179773019992 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1179773019993 active site 1179773019994 HIGH motif; other site 1179773019995 dimer interface [polypeptide binding]; other site 1179773019996 KMSKS motif; other site 1179773019997 FO synthase; Reviewed; Region: fbiC; PRK09234 1179773019998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773019999 FeS/SAM binding site; other site 1179773020000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1179773020001 FeS/SAM binding site; other site 1179773020002 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 1179773020003 Chorismate mutase type II; Region: CM_2; smart00830 1179773020004 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1179773020005 putative active site [active] 1179773020006 putative catalytic site [active] 1179773020007 putative DNA binding site [nucleotide binding]; other site 1179773020008 putative phosphate binding site [ion binding]; other site 1179773020009 metal binding site A [ion binding]; metal-binding site 1179773020010 putative AP binding site [nucleotide binding]; other site 1179773020011 putative metal binding site B [ion binding]; other site 1179773020012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773020013 Cytochrome P450; Region: p450; cl12078 1179773020014 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1179773020015 isocitrate dehydrogenase; Validated; Region: PRK08299 1179773020016 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1179773020017 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1179773020018 HSP70 interaction site [polypeptide binding]; other site 1179773020019 Nuclease-related domain; Region: NERD; pfam08378 1179773020020 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1179773020021 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1179773020022 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1179773020023 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1179773020024 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1179773020025 catalytic residues [active] 1179773020026 Recombinase; Region: Recombinase; pfam07508 1179773020027 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1179773020028 HNH endonuclease; Region: HNH_2; pfam13391 1179773020029 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1179773020030 dimer interface [polypeptide binding]; other site 1179773020031 ADP-ribose binding site [chemical binding]; other site 1179773020032 active site 1179773020033 nudix motif; other site 1179773020034 metal binding site [ion binding]; metal-binding site 1179773020035 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1179773020036 minor groove reading motif; other site 1179773020037 helix-hairpin-helix signature motif; other site 1179773020038 active site 1179773020039 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1179773020040 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1179773020041 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773020042 Switch II region; other site 1179773020043 G3 box; other site 1179773020044 GTP/Mg2+ binding site [chemical binding]; other site 1179773020045 G4 box; other site 1179773020046 G5 box; other site 1179773020047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773020048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1179773020049 active site 1179773020050 ATP binding site [chemical binding]; other site 1179773020051 substrate binding site [chemical binding]; other site 1179773020052 activation loop (A-loop); other site 1179773020053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773020054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773020055 putative substrate translocation pore; other site 1179773020056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773020057 dimerization interface [polypeptide binding]; other site 1179773020058 putative DNA binding site [nucleotide binding]; other site 1179773020059 putative Zn2+ binding site [ion binding]; other site 1179773020060 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1179773020061 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1179773020062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773020063 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773020064 Walker A/P-loop; other site 1179773020065 ATP binding site [chemical binding]; other site 1179773020066 Q-loop/lid; other site 1179773020067 ABC transporter signature motif; other site 1179773020068 Walker B; other site 1179773020069 D-loop; other site 1179773020070 H-loop/switch region; other site 1179773020071 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1179773020072 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1179773020073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773020074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773020075 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773020076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773020077 NAD(P) binding site [chemical binding]; other site 1179773020078 active site 1179773020079 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1179773020080 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1179773020081 active site 1179773020082 malate dehydrogenase; Provisional; Region: PRK05442 1179773020083 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1179773020084 NAD(P) binding site [chemical binding]; other site 1179773020085 dimer interface [polypeptide binding]; other site 1179773020086 malate binding site [chemical binding]; other site 1179773020087 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1179773020088 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1179773020089 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1179773020090 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1179773020091 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1179773020092 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1179773020093 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1179773020094 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1179773020095 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1179773020096 homodimer interface [polypeptide binding]; other site 1179773020097 NADP binding site [chemical binding]; other site 1179773020098 substrate binding site [chemical binding]; other site 1179773020099 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1179773020100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773020101 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1179773020102 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1179773020103 NADP+ binding site [chemical binding]; other site 1179773020104 folate binding site [chemical binding]; other site 1179773020105 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1179773020106 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1179773020107 active site 1179773020108 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1179773020109 generic binding surface II; other site 1179773020110 generic binding surface I; other site 1179773020111 Y-family of DNA polymerases; Region: PolY; cl12025 1179773020112 active site 1179773020113 DNA binding site [nucleotide binding] 1179773020114 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1179773020115 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1179773020116 purine monophosphate binding site [chemical binding]; other site 1179773020117 dimer interface [polypeptide binding]; other site 1179773020118 putative catalytic residues [active] 1179773020119 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1179773020120 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1179773020121 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1179773020122 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1179773020123 active site 1179773020124 cosubstrate binding site; other site 1179773020125 substrate binding site [chemical binding]; other site 1179773020126 catalytic site [active] 1179773020127 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1179773020128 CoA binding domain; Region: CoA_binding; smart00881 1179773020129 CoA-ligase; Region: Ligase_CoA; pfam00549 1179773020130 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1179773020131 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1179773020132 CoA-ligase; Region: Ligase_CoA; pfam00549 1179773020133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773020134 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1179773020135 nucleophilic elbow; other site 1179773020136 catalytic triad; other site 1179773020137 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1179773020138 Peptidase family M23; Region: Peptidase_M23; pfam01551 1179773020139 Predicted transcriptional regulators [Transcription]; Region: COG1733 1179773020140 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1179773020141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773020142 putative substrate translocation pore; other site 1179773020143 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1179773020144 Part of AAA domain; Region: AAA_19; pfam13245 1179773020145 Family description; Region: UvrD_C_2; pfam13538 1179773020146 hypothetical protein; Provisional; Region: PRK07857 1179773020147 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1179773020148 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1179773020149 active site 1179773020150 metal binding site [ion binding]; metal-binding site 1179773020151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773020152 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773020153 active site 1179773020154 ATP binding site [chemical binding]; other site 1179773020155 substrate binding site [chemical binding]; other site 1179773020156 activation loop (A-loop); other site 1179773020157 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1179773020158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1179773020159 active site 1179773020160 ATP binding site [chemical binding]; other site 1179773020161 substrate binding site [chemical binding]; other site 1179773020162 activation loop (A-loop); other site 1179773020163 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1179773020164 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1179773020165 EamA-like transporter family; Region: EamA; pfam00892 1179773020166 EamA-like transporter family; Region: EamA; pfam00892 1179773020167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773020168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773020169 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773020170 putative dimerization interface [polypeptide binding]; other site 1179773020171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773020172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773020173 active site 1179773020174 phosphorylation site [posttranslational modification] 1179773020175 intermolecular recognition site; other site 1179773020176 dimerization interface [polypeptide binding]; other site 1179773020177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773020178 DNA binding residues [nucleotide binding] 1179773020179 dimerization interface [polypeptide binding]; other site 1179773020180 PspC domain; Region: PspC; pfam04024 1179773020181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773020182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773020183 ATP binding site [chemical binding]; other site 1179773020184 Mg2+ binding site [ion binding]; other site 1179773020185 G-X-G motif; other site 1179773020186 PspC domain; Region: PspC; pfam04024 1179773020187 GMP synthase; Reviewed; Region: guaA; PRK00074 1179773020188 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1179773020189 AMP/PPi binding site [chemical binding]; other site 1179773020190 candidate oxyanion hole; other site 1179773020191 catalytic triad [active] 1179773020192 potential glutamine specificity residues [chemical binding]; other site 1179773020193 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1179773020194 ATP Binding subdomain [chemical binding]; other site 1179773020195 Ligand Binding sites [chemical binding]; other site 1179773020196 Dimerization subdomain; other site 1179773020197 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1179773020198 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1179773020199 NAD(P) binding site [chemical binding]; other site 1179773020200 catalytic residues [active] 1179773020201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773020202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773020203 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1179773020204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773020205 NAD(P) binding site [chemical binding]; other site 1179773020206 active site 1179773020207 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773020208 FAD binding domain; Region: FAD_binding_3; pfam01494 1179773020209 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773020210 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1179773020211 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1179773020212 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1179773020213 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1179773020214 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1179773020215 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1179773020216 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773020217 phosphate binding site [ion binding]; other site 1179773020218 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1179773020219 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1179773020220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1179773020221 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1179773020222 active site 1179773020223 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1179773020224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773020225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773020226 DNA binding residues [nucleotide binding] 1179773020227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773020228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773020229 DNA binding residues [nucleotide binding] 1179773020230 dimerization interface [polypeptide binding]; other site 1179773020231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1179773020232 active site 1179773020233 phosphorylation site [posttranslational modification] 1179773020234 intermolecular recognition site; other site 1179773020235 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773020236 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1179773020237 DNA binding residues [nucleotide binding] 1179773020238 Transcription factor WhiB; Region: Whib; pfam02467 1179773020239 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1179773020240 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1179773020241 ring oligomerisation interface [polypeptide binding]; other site 1179773020242 ATP/Mg binding site [chemical binding]; other site 1179773020243 stacking interactions; other site 1179773020244 hinge regions; other site 1179773020245 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1179773020246 oligomerisation interface [polypeptide binding]; other site 1179773020247 mobile loop; other site 1179773020248 roof hairpin; other site 1179773020249 PhoD-like phosphatase; Region: PhoD; pfam09423 1179773020250 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1179773020251 putative active site [active] 1179773020252 putative metal binding site [ion binding]; other site 1179773020253 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1179773020254 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1179773020255 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1179773020256 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773020257 Predicted ATPase [General function prediction only]; Region: COG3903 1179773020258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1179773020259 UGMP family protein; Validated; Region: PRK09604 1179773020260 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1179773020261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773020262 Coenzyme A binding pocket [chemical binding]; other site 1179773020263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773020264 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1179773020265 Glycoprotease family; Region: Peptidase_M22; pfam00814 1179773020266 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773020267 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1179773020268 DNA binding residues [nucleotide binding] 1179773020269 putative dimer interface [polypeptide binding]; other site 1179773020270 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1179773020271 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773020272 catalytic residues [active] 1179773020273 acyl-CoA synthetase; Validated; Region: PRK07787 1179773020274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773020275 acyl-activating enzyme (AAE) consensus motif; other site 1179773020276 AMP binding site [chemical binding]; other site 1179773020277 active site 1179773020278 CoA binding site [chemical binding]; other site 1179773020279 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1179773020280 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773020281 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1179773020282 TAP-like protein; Region: Abhydrolase_4; pfam08386 1179773020283 alanine racemase; Reviewed; Region: alr; PRK00053 1179773020284 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1179773020285 active site 1179773020286 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773020287 dimer interface [polypeptide binding]; other site 1179773020288 substrate binding site [chemical binding]; other site 1179773020289 catalytic residues [active] 1179773020290 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1179773020291 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1179773020292 putative substrate binding site [chemical binding]; other site 1179773020293 putative ATP binding site [chemical binding]; other site 1179773020294 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1179773020295 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1179773020296 glutaminase active site [active] 1179773020297 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1179773020298 dimer interface [polypeptide binding]; other site 1179773020299 active site 1179773020300 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1179773020301 dimer interface [polypeptide binding]; other site 1179773020302 active site 1179773020303 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773020304 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1179773020305 nucleophilic elbow; other site 1179773020306 catalytic triad; other site 1179773020307 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773020308 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1179773020309 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1179773020310 active site 1179773020311 substrate binding site [chemical binding]; other site 1179773020312 metal binding site [ion binding]; metal-binding site 1179773020313 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1179773020314 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1179773020315 23S rRNA interface [nucleotide binding]; other site 1179773020316 L3 interface [polypeptide binding]; other site 1179773020317 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1179773020318 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1179773020319 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1179773020320 nucleotide binding site [chemical binding]; other site 1179773020321 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1179773020322 SBD interface [polypeptide binding]; other site 1179773020323 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1179773020324 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1179773020325 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773020326 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1179773020327 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773020328 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773020329 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1179773020330 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773020331 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1179773020332 active site 1179773020333 catalytic residues [active] 1179773020334 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1179773020335 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1179773020336 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1179773020337 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1179773020338 calcium binding site 2 [ion binding]; other site 1179773020339 active site 1179773020340 catalytic triad [active] 1179773020341 calcium binding site 1 [ion binding]; other site 1179773020342 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1179773020343 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773020344 putative active site [active] 1179773020345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1179773020346 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1179773020347 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1179773020348 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1179773020349 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1179773020350 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1179773020351 dimerization interface 3.5A [polypeptide binding]; other site 1179773020352 active site 1179773020353 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1179773020354 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1179773020355 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1179773020356 alphaNTD homodimer interface [polypeptide binding]; other site 1179773020357 alphaNTD - beta interaction site [polypeptide binding]; other site 1179773020358 alphaNTD - beta' interaction site [polypeptide binding]; other site 1179773020359 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1179773020360 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1179773020361 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1179773020362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1179773020363 RNA binding surface [nucleotide binding]; other site 1179773020364 30S ribosomal protein S11; Validated; Region: PRK05309 1179773020365 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1179773020366 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1179773020367 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1179773020368 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1179773020369 rRNA binding site [nucleotide binding]; other site 1179773020370 predicted 30S ribosome binding site; other site 1179773020371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773020372 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773020373 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1179773020374 active site 1179773020375 adenylate kinase; Reviewed; Region: adk; PRK00279 1179773020376 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1179773020377 AMP-binding site [chemical binding]; other site 1179773020378 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1179773020379 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1179773020380 SecY translocase; Region: SecY; pfam00344 1179773020381 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1179773020382 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1179773020383 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1179773020384 23S rRNA binding site [nucleotide binding]; other site 1179773020385 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1179773020386 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1179773020387 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1179773020388 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1179773020389 5S rRNA interface [nucleotide binding]; other site 1179773020390 L27 interface [polypeptide binding]; other site 1179773020391 23S rRNA interface [nucleotide binding]; other site 1179773020392 L5 interface [polypeptide binding]; other site 1179773020393 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1179773020394 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1179773020395 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1179773020396 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1179773020397 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1179773020398 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1179773020399 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1179773020400 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1179773020401 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1179773020402 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1179773020403 RNA binding site [nucleotide binding]; other site 1179773020404 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1179773020405 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1179773020406 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1179773020407 L23 interface [polypeptide binding]; other site 1179773020408 signal recognition particle (SRP54) interaction site; other site 1179773020409 trigger factor interaction site; other site 1179773020410 23S rRNA interface [nucleotide binding]; other site 1179773020411 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1179773020412 23S rRNA interface [nucleotide binding]; other site 1179773020413 5S rRNA interface [nucleotide binding]; other site 1179773020414 putative antibiotic binding site [chemical binding]; other site 1179773020415 L25 interface [polypeptide binding]; other site 1179773020416 L27 interface [polypeptide binding]; other site 1179773020417 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1179773020418 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1179773020419 G-X-X-G motif; other site 1179773020420 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1179773020421 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1179773020422 putative translocon binding site; other site 1179773020423 protein-rRNA interface [nucleotide binding]; other site 1179773020424 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1179773020425 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1179773020426 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1179773020427 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1179773020428 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1179773020429 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1179773020430 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1179773020431 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1179773020432 elongation factor Tu; Reviewed; Region: PRK00049 1179773020433 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1179773020434 G1 box; other site 1179773020435 GEF interaction site [polypeptide binding]; other site 1179773020436 GTP/Mg2+ binding site [chemical binding]; other site 1179773020437 Switch I region; other site 1179773020438 G2 box; other site 1179773020439 G3 box; other site 1179773020440 Switch II region; other site 1179773020441 G4 box; other site 1179773020442 G5 box; other site 1179773020443 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1179773020444 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1179773020445 Antibiotic Binding Site [chemical binding]; other site 1179773020446 elongation factor G; Reviewed; Region: PRK00007 1179773020447 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1179773020448 G1 box; other site 1179773020449 putative GEF interaction site [polypeptide binding]; other site 1179773020450 GTP/Mg2+ binding site [chemical binding]; other site 1179773020451 Switch I region; other site 1179773020452 G2 box; other site 1179773020453 G3 box; other site 1179773020454 Switch II region; other site 1179773020455 G4 box; other site 1179773020456 G5 box; other site 1179773020457 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1179773020458 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1179773020459 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1179773020460 30S ribosomal protein S7; Validated; Region: PRK05302 1179773020461 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1179773020462 S17 interaction site [polypeptide binding]; other site 1179773020463 S8 interaction site; other site 1179773020464 16S rRNA interaction site [nucleotide binding]; other site 1179773020465 streptomycin interaction site [chemical binding]; other site 1179773020466 23S rRNA interaction site [nucleotide binding]; other site 1179773020467 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1179773020468 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773020469 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773020470 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1179773020471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773020472 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1179773020473 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1179773020474 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1179773020475 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1179773020476 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1179773020477 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1179773020478 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1179773020479 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1179773020480 DNA binding site [nucleotide binding] 1179773020481 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1179773020482 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1179773020483 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1179773020484 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1179773020485 RPB10 interaction site [polypeptide binding]; other site 1179773020486 RPB1 interaction site [polypeptide binding]; other site 1179773020487 RPB11 interaction site [polypeptide binding]; other site 1179773020488 RPB3 interaction site [polypeptide binding]; other site 1179773020489 RPB12 interaction site [polypeptide binding]; other site 1179773020490 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020491 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020492 mce related protein; Region: MCE; pfam02470 1179773020493 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1179773020494 mce related protein; Region: MCE; pfam02470 1179773020495 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020496 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020497 mce related protein; Region: MCE; pfam02470 1179773020498 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020499 mce related protein; Region: MCE; pfam02470 1179773020500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1179773020501 mce related protein; Region: MCE; pfam02470 1179773020502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1179773020503 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1179773020504 Permease; Region: Permease; pfam02405 1179773020505 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1179773020506 Permease; Region: Permease; pfam02405 1179773020507 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1179773020508 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1179773020509 Walker A/P-loop; other site 1179773020510 ATP binding site [chemical binding]; other site 1179773020511 Q-loop/lid; other site 1179773020512 ABC transporter signature motif; other site 1179773020513 Walker B; other site 1179773020514 D-loop; other site 1179773020515 H-loop/switch region; other site 1179773020516 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1179773020517 core dimer interface [polypeptide binding]; other site 1179773020518 peripheral dimer interface [polypeptide binding]; other site 1179773020519 L10 interface [polypeptide binding]; other site 1179773020520 L11 interface [polypeptide binding]; other site 1179773020521 putative EF-Tu interaction site [polypeptide binding]; other site 1179773020522 putative EF-G interaction site [polypeptide binding]; other site 1179773020523 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1179773020524 23S rRNA interface [nucleotide binding]; other site 1179773020525 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1179773020526 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1179773020527 mRNA/rRNA interface [nucleotide binding]; other site 1179773020528 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1179773020529 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1179773020530 23S rRNA interface [nucleotide binding]; other site 1179773020531 putative thiostrepton binding site; other site 1179773020532 L7/L12 interface [polypeptide binding]; other site 1179773020533 L25 interface [polypeptide binding]; other site 1179773020534 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1179773020535 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1179773020536 putative homodimer interface [polypeptide binding]; other site 1179773020537 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1179773020538 heterodimer interface [polypeptide binding]; other site 1179773020539 homodimer interface [polypeptide binding]; other site 1179773020540 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1179773020541 aspartate aminotransferase; Provisional; Region: PRK05764 1179773020542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773020543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773020544 homodimer interface [polypeptide binding]; other site 1179773020545 catalytic residue [active] 1179773020546 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1179773020547 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1179773020548 active site 1179773020549 catalytic site [active] 1179773020550 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1179773020551 active site 1179773020552 catalytic site [active] 1179773020553 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1179773020554 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1179773020555 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1179773020556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773020557 metal binding site [ion binding]; metal-binding site 1179773020558 active site 1179773020559 I-site; other site 1179773020560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773020561 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1179773020562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1179773020563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773020564 Coenzyme A binding pocket [chemical binding]; other site 1179773020565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1179773020566 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1179773020567 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1179773020568 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1179773020569 substrate binding site; other site 1179773020570 tetramer interface; other site 1179773020571 heat shock protein HtpX; Provisional; Region: PRK03072 1179773020572 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1179773020573 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773020574 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 1179773020575 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1179773020576 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1179773020577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773020578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1179773020579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1179773020580 dimerization interface [polypeptide binding]; other site 1179773020581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1179773020582 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1179773020583 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1179773020584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773020585 non-specific DNA binding site [nucleotide binding]; other site 1179773020586 salt bridge; other site 1179773020587 sequence-specific DNA binding site [nucleotide binding]; other site 1179773020588 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1179773020589 Phosphotransferase enzyme family; Region: APH; pfam01636 1179773020590 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1179773020591 active site 1179773020592 ATP binding site [chemical binding]; other site 1179773020593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773020594 DNA-binding site [nucleotide binding]; DNA binding site 1179773020595 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1179773020596 Transcription factor WhiB; Region: Whib; pfam02467 1179773020597 Helix-turn-helix domain; Region: HTH_17; pfam12728 1179773020598 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1179773020599 active site 1179773020600 catalytic residues [active] 1179773020601 DNA binding site [nucleotide binding] 1179773020602 Int/Topo IB signature motif; other site 1179773020603 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1179773020604 Amidinotransferase; Region: Amidinotransf; pfam02274 1179773020605 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1179773020606 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1179773020607 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773020608 enoyl-CoA hydratase; Provisional; Region: PRK05870 1179773020609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773020610 substrate binding site [chemical binding]; other site 1179773020611 oxyanion hole (OAH) forming residues; other site 1179773020612 trimer interface [polypeptide binding]; other site 1179773020613 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1179773020614 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1179773020615 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1179773020616 dimer interface [polypeptide binding]; other site 1179773020617 PYR/PP interface [polypeptide binding]; other site 1179773020618 TPP binding site [chemical binding]; other site 1179773020619 substrate binding site [chemical binding]; other site 1179773020620 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1179773020621 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1179773020622 TPP-binding site [chemical binding]; other site 1179773020623 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1179773020624 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1179773020625 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1179773020626 substrate binding pocket [chemical binding]; other site 1179773020627 chain length determination region; other site 1179773020628 substrate-Mg2+ binding site; other site 1179773020629 catalytic residues [active] 1179773020630 aspartate-rich region 1; other site 1179773020631 active site lid residues [active] 1179773020632 aspartate-rich region 2; other site 1179773020633 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1179773020634 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1179773020635 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 1179773020636 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1179773020637 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1179773020638 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1179773020639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1179773020640 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1179773020641 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1179773020642 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1179773020643 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1179773020644 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1179773020645 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773020646 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773020647 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1179773020648 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1179773020649 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1179773020650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1179773020651 catalytic loop [active] 1179773020652 iron binding site [ion binding]; other site 1179773020653 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1179773020654 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1179773020655 molybdopterin cofactor binding site; other site 1179773020656 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1179773020657 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1179773020658 SLBB domain; Region: SLBB; pfam10531 1179773020659 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1179773020660 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1179773020661 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1179773020662 putative dimer interface [polypeptide binding]; other site 1179773020663 [2Fe-2S] cluster binding site [ion binding]; other site 1179773020664 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1179773020665 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1179773020666 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 1179773020667 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1179773020668 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1179773020669 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1179773020670 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1179773020671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1179773020672 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1179773020673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773020674 S-adenosylmethionine binding site [chemical binding]; other site 1179773020675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773020676 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1179773020677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1179773020678 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1179773020679 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1179773020680 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1179773020681 active site 1179773020682 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1179773020683 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1179773020684 FAD binding pocket [chemical binding]; other site 1179773020685 FAD binding motif [chemical binding]; other site 1179773020686 phosphate binding motif [ion binding]; other site 1179773020687 beta-alpha-beta structure motif; other site 1179773020688 NAD(p) ribose binding residues [chemical binding]; other site 1179773020689 NAD binding pocket [chemical binding]; other site 1179773020690 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1179773020691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1179773020692 catalytic loop [active] 1179773020693 iron binding site [ion binding]; other site 1179773020694 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1179773020695 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1179773020696 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1179773020697 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1179773020698 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1179773020699 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1179773020700 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1179773020701 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1179773020702 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773020703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773020704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1179773020705 DNA binding residues [nucleotide binding] 1179773020706 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1179773020707 Peptidase family M1; Region: Peptidase_M1; pfam01433 1179773020708 Zn binding site [ion binding]; other site 1179773020709 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1179773020710 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1179773020711 dimer interface [polypeptide binding]; other site 1179773020712 tetramer interface [polypeptide binding]; other site 1179773020713 PYR/PP interface [polypeptide binding]; other site 1179773020714 TPP binding site [chemical binding]; other site 1179773020715 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1179773020716 TPP-binding site; other site 1179773020717 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1179773020718 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1179773020719 substrate binding site [chemical binding]; other site 1179773020720 oxyanion hole (OAH) forming residues; other site 1179773020721 trimer interface [polypeptide binding]; other site 1179773020722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773020723 active site 1179773020724 CoA binding site [chemical binding]; other site 1179773020725 AMP binding site [chemical binding]; other site 1179773020726 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1179773020727 UbiA prenyltransferase family; Region: UbiA; pfam01040 1179773020728 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1179773020729 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1179773020730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773020731 catalytic residue [active] 1179773020732 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1179773020733 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773020734 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773020735 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00198 1179773020736 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1179773020737 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773020738 putative DNA binding site [nucleotide binding]; other site 1179773020739 putative Zn2+ binding site [ion binding]; other site 1179773020740 AsnC family; Region: AsnC_trans_reg; pfam01037 1179773020741 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1179773020742 DNA binding residues [nucleotide binding] 1179773020743 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1179773020744 nudix motif; other site 1179773020745 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1179773020746 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1179773020747 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1179773020748 ResB-like family; Region: ResB; pfam05140 1179773020749 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1179773020750 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1179773020751 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1179773020752 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1179773020753 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773020754 catalytic residues [active] 1179773020755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773020756 catalytic core [active] 1179773020757 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1179773020758 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1179773020759 inhibitor-cofactor binding pocket; inhibition site 1179773020760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773020761 catalytic residue [active] 1179773020762 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1179773020763 dimer interface [polypeptide binding]; other site 1179773020764 active site 1179773020765 Schiff base residues; other site 1179773020766 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1179773020767 homodimer interface [polypeptide binding]; other site 1179773020768 active site 1179773020769 SAM binding site [chemical binding]; other site 1179773020770 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1179773020771 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1179773020772 active site 1179773020773 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1179773020774 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1179773020775 domain interfaces; other site 1179773020776 active site 1179773020777 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1179773020778 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1179773020779 tRNA; other site 1179773020780 putative tRNA binding site [nucleotide binding]; other site 1179773020781 putative NADP binding site [chemical binding]; other site 1179773020782 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1179773020783 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1179773020784 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1179773020785 CoA binding domain; Region: CoA_binding; pfam02629 1179773020786 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1179773020787 Fasciclin domain; Region: Fasciclin; pfam02469 1179773020788 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1179773020789 Moco binding site; other site 1179773020790 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1179773020791 metal coordination site [ion binding]; other site 1179773020792 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1179773020793 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1179773020794 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1179773020795 acyl-activating enzyme (AAE) consensus motif; other site 1179773020796 AMP binding site [chemical binding]; other site 1179773020797 active site 1179773020798 CoA binding site [chemical binding]; other site 1179773020799 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1179773020800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773020801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773020802 DNA binding residues [nucleotide binding] 1179773020803 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1179773020804 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1179773020805 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1179773020806 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1179773020807 putative acyl-acceptor binding pocket; other site 1179773020808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1179773020809 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1179773020810 putative NAD(P) binding site [chemical binding]; other site 1179773020811 active site 1179773020812 putative substrate binding site [chemical binding]; other site 1179773020813 DNA binding domain, excisionase family; Region: excise; TIGR01764 1179773020814 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1179773020815 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1179773020816 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1179773020817 Proline dehydrogenase; Region: Pro_dh; cl03282 1179773020818 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1179773020819 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1179773020820 Metal-binding active site; metal-binding site 1179773020821 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1179773020822 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1179773020823 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773020824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773020825 active site 1179773020826 phosphorylation site [posttranslational modification] 1179773020827 intermolecular recognition site; other site 1179773020828 dimerization interface [polypeptide binding]; other site 1179773020829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773020830 DNA binding site [nucleotide binding] 1179773020831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1179773020832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1179773020833 dimer interface [polypeptide binding]; other site 1179773020834 phosphorylation site [posttranslational modification] 1179773020835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773020836 ATP binding site [chemical binding]; other site 1179773020837 Mg2+ binding site [ion binding]; other site 1179773020838 G-X-G motif; other site 1179773020839 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773020840 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773020841 active site 1179773020842 catalytic tetrad [active] 1179773020843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773020844 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1179773020845 dimerization interface [polypeptide binding]; other site 1179773020846 DNA binding residues [nucleotide binding] 1179773020847 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773020848 catalytic core [active] 1179773020849 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773020850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1179773020851 homotrimer interaction site [polypeptide binding]; other site 1179773020852 putative active site [active] 1179773020853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773020854 4-coumarate--CoA ligase; Region: PLN02246 1179773020855 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1179773020856 acyl-activating enzyme (AAE) consensus motif; other site 1179773020857 active site 1179773020858 putative CoA binding site [chemical binding]; other site 1179773020859 AMP binding site [chemical binding]; other site 1179773020860 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1179773020861 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1179773020862 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1179773020863 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1179773020864 putative ADP-binding pocket [chemical binding]; other site 1179773020865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773020866 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1179773020867 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1179773020868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1179773020869 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1179773020870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1179773020871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773020872 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1179773020873 NAD(P) binding site [chemical binding]; other site 1179773020874 active site 1179773020875 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1179773020876 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773020877 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1179773020878 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1179773020879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773020880 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1179773020881 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1179773020882 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1179773020883 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1179773020884 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1179773020885 putative active site [active] 1179773020886 putative substrate binding site [chemical binding]; other site 1179773020887 putative cosubstrate binding site; other site 1179773020888 catalytic site [active] 1179773020889 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773020890 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1179773020891 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1179773020892 putative deacylase active site [active] 1179773020893 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1179773020894 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1179773020895 DNA binding residues [nucleotide binding] 1179773020896 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1179773020897 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1179773020898 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1179773020899 proposed catalytic triad [active] 1179773020900 conserved cys residue [active] 1179773020901 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773020902 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1179773020903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773020904 non-specific DNA binding site [nucleotide binding]; other site 1179773020905 salt bridge; other site 1179773020906 sequence-specific DNA binding site [nucleotide binding]; other site 1179773020907 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1179773020908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773020909 S-adenosylmethionine binding site [chemical binding]; other site 1179773020910 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1179773020911 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1179773020912 aminotransferase; Validated; Region: PRK07777 1179773020913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773020914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773020915 homodimer interface [polypeptide binding]; other site 1179773020916 catalytic residue [active] 1179773020917 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1179773020918 CGNR zinc finger; Region: zf-CGNR; pfam11706 1179773020919 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773020920 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773020921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1179773020922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1179773020923 Walker A/P-loop; other site 1179773020924 ATP binding site [chemical binding]; other site 1179773020925 Q-loop/lid; other site 1179773020926 ABC transporter signature motif; other site 1179773020927 Walker B; other site 1179773020928 D-loop; other site 1179773020929 H-loop/switch region; other site 1179773020930 FtsX-like permease family; Region: FtsX; pfam02687 1179773020931 FtsX-like permease family; Region: FtsX; pfam02687 1179773020932 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773020933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773020934 CHAT domain; Region: CHAT; cl17868 1179773020935 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1179773020936 active site 1179773020937 catalytic residues [active] 1179773020938 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1179773020939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773020940 DNA-binding site [nucleotide binding]; DNA binding site 1179773020941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773020942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773020943 homodimer interface [polypeptide binding]; other site 1179773020944 catalytic residue [active] 1179773020945 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1179773020946 Predicted membrane protein [Function unknown]; Region: COG2364 1179773020947 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773020948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773020949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773020950 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1179773020951 metal-binding site [ion binding] 1179773020952 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1179773020953 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1179773020954 metal-binding site [ion binding] 1179773020955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1179773020956 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1179773020957 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1179773020958 DNA-binding site [nucleotide binding]; DNA binding site 1179773020959 RNA-binding motif; other site 1179773020960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773020961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773020962 substrate binding pocket [chemical binding]; other site 1179773020963 membrane-bound complex binding site; other site 1179773020964 hinge residues; other site 1179773020965 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1179773020966 AAA domain; Region: AAA_22; pfam13401 1179773020967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773020968 Walker A motif; other site 1179773020969 ATP binding site [chemical binding]; other site 1179773020970 Walker B motif; other site 1179773020971 arginine finger; other site 1179773020972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1179773020973 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1179773020974 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1179773020975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773020976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773020977 hypothetical protein; Provisional; Region: PRK07236 1179773020978 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1179773020979 putative catalytic site [active] 1179773020980 putative metal binding site [ion binding]; other site 1179773020981 putative phosphate binding site [ion binding]; other site 1179773020982 AAA ATPase domain; Region: AAA_16; pfam13191 1179773020983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773020984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773020985 DNA binding residues [nucleotide binding] 1179773020986 dimerization interface [polypeptide binding]; other site 1179773020987 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1179773020988 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1179773020989 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1179773020990 active site 1179773020991 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1179773020992 substrate binding site [chemical binding]; other site 1179773020993 catalytic residues [active] 1179773020994 dimer interface [polypeptide binding]; other site 1179773020995 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1179773020996 Sulfatase; Region: Sulfatase; cl17466 1179773020997 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1179773020998 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1179773020999 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1179773021000 FMN binding site [chemical binding]; other site 1179773021001 active site 1179773021002 catalytic residues [active] 1179773021003 substrate binding site [chemical binding]; other site 1179773021004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773021005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773021006 metal binding site [ion binding]; metal-binding site 1179773021007 active site 1179773021008 I-site; other site 1179773021009 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1179773021010 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1179773021011 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1179773021012 PhoU domain; Region: PhoU; pfam01895 1179773021013 PhoU domain; Region: PhoU; pfam01895 1179773021014 EspG family; Region: ESX-1_EspG; pfam14011 1179773021015 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1179773021016 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1179773021017 Walker A/P-loop; other site 1179773021018 ATP binding site [chemical binding]; other site 1179773021019 Q-loop/lid; other site 1179773021020 ABC transporter signature motif; other site 1179773021021 Walker B; other site 1179773021022 D-loop; other site 1179773021023 H-loop/switch region; other site 1179773021024 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1179773021025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773021026 dimer interface [polypeptide binding]; other site 1179773021027 conserved gate region; other site 1179773021028 putative PBP binding loops; other site 1179773021029 ABC-ATPase subunit interface; other site 1179773021030 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1179773021031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773021032 dimer interface [polypeptide binding]; other site 1179773021033 conserved gate region; other site 1179773021034 putative PBP binding loops; other site 1179773021035 ABC-ATPase subunit interface; other site 1179773021036 PBP superfamily domain; Region: PBP_like_2; cl17296 1179773021037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773021038 Coenzyme A binding pocket [chemical binding]; other site 1179773021039 putative acetyltransferase; Provisional; Region: PRK03624 1179773021040 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773021041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1179773021042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1179773021043 DNA binding site [nucleotide binding] 1179773021044 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1179773021045 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1179773021046 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1179773021047 catalytic residues [active] 1179773021048 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1179773021049 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1179773021050 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1179773021051 active site residue [active] 1179773021052 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1179773021053 active site residue [active] 1179773021054 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1179773021055 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1179773021056 heme-binding site [chemical binding]; other site 1179773021057 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1179773021058 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1179773021059 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1179773021060 CBD_II domain; Region: CBD_II; smart00637 1179773021061 CBD_II domain; Region: CBD_II; smart00637 1179773021062 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1179773021063 Interdomain contacts; other site 1179773021064 Cytokine receptor motif; other site 1179773021065 Glyco_18 domain; Region: Glyco_18; smart00636 1179773021066 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773021067 active site 1179773021068 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1179773021069 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1179773021070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773021071 catalytic residue [active] 1179773021072 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1179773021073 metal binding site 2 [ion binding]; metal-binding site 1179773021074 putative DNA binding helix; other site 1179773021075 metal binding site 1 [ion binding]; metal-binding site 1179773021076 dimer interface [polypeptide binding]; other site 1179773021077 structural Zn2+ binding site [ion binding]; other site 1179773021078 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1179773021079 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1179773021080 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1179773021081 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1179773021082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773021083 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1179773021084 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1179773021085 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1179773021086 active site 1179773021087 FMN binding site [chemical binding]; other site 1179773021088 substrate binding site [chemical binding]; other site 1179773021089 homotetramer interface [polypeptide binding]; other site 1179773021090 catalytic residue [active] 1179773021091 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1179773021092 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1179773021093 ligand binding site [chemical binding]; other site 1179773021094 flexible hinge region; other site 1179773021095 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1179773021096 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1179773021097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021098 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773021099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1179773021100 classical (c) SDRs; Region: SDR_c; cd05233 1179773021101 NAD(P) binding site [chemical binding]; other site 1179773021102 active site 1179773021103 hypothetical protein; Provisional; Region: PRK09256 1179773021104 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773021105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021107 DNA binding residues [nucleotide binding] 1179773021108 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1179773021109 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1179773021110 dimerization interface [polypeptide binding]; other site 1179773021111 putative ATP binding site [chemical binding]; other site 1179773021112 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1179773021113 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1179773021114 active site 1179773021115 tetramer interface [polypeptide binding]; other site 1179773021116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1179773021117 active site 1179773021118 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1179773021119 EspG family; Region: ESX-1_EspG; pfam14011 1179773021120 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1179773021121 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1179773021122 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1179773021123 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1179773021124 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773021125 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1179773021126 NAD(P) binding site [chemical binding]; other site 1179773021127 PAS domain S-box; Region: sensory_box; TIGR00229 1179773021128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1179773021129 putative active site [active] 1179773021130 heme pocket [chemical binding]; other site 1179773021131 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773021132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773021133 metal binding site [ion binding]; metal-binding site 1179773021134 active site 1179773021135 I-site; other site 1179773021136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1179773021137 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1179773021138 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773021139 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773021140 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021141 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773021142 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773021143 active site 1179773021144 catalytic tetrad [active] 1179773021145 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1179773021146 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1179773021147 active site 1179773021148 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1179773021149 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1179773021150 active site 1179773021151 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1179773021152 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1179773021153 dimerization interface [polypeptide binding]; other site 1179773021154 ATP binding site [chemical binding]; other site 1179773021155 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1179773021156 dimerization interface [polypeptide binding]; other site 1179773021157 ATP binding site [chemical binding]; other site 1179773021158 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1179773021159 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1179773021160 putative active site [active] 1179773021161 catalytic triad [active] 1179773021162 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1179773021163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021164 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1179773021165 NAD(P) binding site [chemical binding]; other site 1179773021166 active site 1179773021167 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1179773021168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1179773021169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1179773021170 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1179773021171 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1179773021172 ATP binding site [chemical binding]; other site 1179773021173 active site 1179773021174 substrate binding site [chemical binding]; other site 1179773021175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773021176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773021177 substrate binding pocket [chemical binding]; other site 1179773021178 membrane-bound complex binding site; other site 1179773021179 hinge residues; other site 1179773021180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773021181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773021182 dimer interface [polypeptide binding]; other site 1179773021183 conserved gate region; other site 1179773021184 putative PBP binding loops; other site 1179773021185 ABC-ATPase subunit interface; other site 1179773021186 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773021187 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1179773021188 Walker A/P-loop; other site 1179773021189 ATP binding site [chemical binding]; other site 1179773021190 Q-loop/lid; other site 1179773021191 ABC transporter signature motif; other site 1179773021192 Walker B; other site 1179773021193 D-loop; other site 1179773021194 H-loop/switch region; other site 1179773021195 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1179773021196 adenylosuccinate lyase; Region: purB; TIGR00928 1179773021197 tetramer interface [polypeptide binding]; other site 1179773021198 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1179773021199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021201 DNA binding residues [nucleotide binding] 1179773021202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773021203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773021204 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773021205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021206 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1179773021207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021208 DNA binding residues [nucleotide binding] 1179773021209 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1179773021210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1179773021211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1179773021212 catalytic residue [active] 1179773021213 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1179773021214 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1179773021215 Ion channel; Region: Ion_trans_2; pfam07885 1179773021216 aspartate aminotransferase; Provisional; Region: PRK05764 1179773021217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773021218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773021219 homodimer interface [polypeptide binding]; other site 1179773021220 catalytic residue [active] 1179773021221 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1179773021222 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1179773021223 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1179773021224 catalytic residue [active] 1179773021225 EspG family; Region: ESX-1_EspG; pfam14011 1179773021226 EspG family; Region: ESX-1_EspG; pfam14011 1179773021227 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1179773021228 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1179773021229 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1179773021230 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1179773021231 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1179773021232 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1179773021233 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1179773021234 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1179773021235 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1179773021236 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1179773021237 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1179773021238 putative active site [active] 1179773021239 catalytic site [active] 1179773021240 putative metal binding site [ion binding]; other site 1179773021241 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1179773021242 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1179773021243 active site 1179773021244 dimer interface [polypeptide binding]; other site 1179773021245 non-prolyl cis peptide bond; other site 1179773021246 insertion regions; other site 1179773021247 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773021248 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1179773021249 substrate binding pocket [chemical binding]; other site 1179773021250 membrane-bound complex binding site; other site 1179773021251 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1179773021252 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1179773021253 Walker A/P-loop; other site 1179773021254 ATP binding site [chemical binding]; other site 1179773021255 Q-loop/lid; other site 1179773021256 ABC transporter signature motif; other site 1179773021257 Walker B; other site 1179773021258 D-loop; other site 1179773021259 H-loop/switch region; other site 1179773021260 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1179773021261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773021262 dimer interface [polypeptide binding]; other site 1179773021263 conserved gate region; other site 1179773021264 putative PBP binding loops; other site 1179773021265 ABC-ATPase subunit interface; other site 1179773021266 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1179773021267 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1179773021268 GDP-binding site [chemical binding]; other site 1179773021269 ACT binding site; other site 1179773021270 IMP binding site; other site 1179773021271 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1179773021272 Predicted membrane protein [Function unknown]; Region: COG4129 1179773021273 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1179773021274 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1179773021275 Beta-lactamase; Region: Beta-lactamase; pfam00144 1179773021276 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1179773021277 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1179773021278 active site 1179773021279 intersubunit interface [polypeptide binding]; other site 1179773021280 zinc binding site [ion binding]; other site 1179773021281 Na+ binding site [ion binding]; other site 1179773021282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1179773021283 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1179773021284 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1179773021285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1179773021286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1179773021287 active site 1179773021288 catalytic tetrad [active] 1179773021289 short chain dehydrogenase; Provisional; Region: PRK05872 1179773021290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021291 NAD(P) binding site [chemical binding]; other site 1179773021292 active site 1179773021293 YCII-related domain; Region: YCII; cl00999 1179773021294 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773021295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021297 DNA binding residues [nucleotide binding] 1179773021298 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1179773021299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773021300 nucleotide binding site [chemical binding]; other site 1179773021301 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1179773021302 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1179773021303 active site 1179773021304 dimer interface [polypeptide binding]; other site 1179773021305 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1179773021306 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1179773021307 Glyco_18 domain; Region: Glyco_18; smart00636 1179773021308 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1179773021309 active site 1179773021310 FAD binding domain; Region: FAD_binding_4; pfam01565 1179773021311 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1179773021312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1179773021313 catalytic core [active] 1179773021314 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1179773021315 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1179773021316 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1179773021317 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1179773021318 active site 1179773021319 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773021320 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773021321 substrate binding site [chemical binding]; other site 1179773021322 ATP binding site [chemical binding]; other site 1179773021323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773021324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773021325 DNA binding site [nucleotide binding] 1179773021326 domain linker motif; other site 1179773021327 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773021328 ligand binding site [chemical binding]; other site 1179773021329 dimerization interface [polypeptide binding]; other site 1179773021330 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1179773021331 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1179773021332 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1179773021333 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1179773021334 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1179773021335 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 1179773021336 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1179773021337 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1179773021338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021339 NAD(P) binding site [chemical binding]; other site 1179773021340 active site 1179773021341 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1179773021342 Clp amino terminal domain; Region: Clp_N; pfam02861 1179773021343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773021344 Walker A motif; other site 1179773021345 ATP binding site [chemical binding]; other site 1179773021346 Walker B motif; other site 1179773021347 arginine finger; other site 1179773021348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1179773021349 Walker A motif; other site 1179773021350 ATP binding site [chemical binding]; other site 1179773021351 Walker B motif; other site 1179773021352 arginine finger; other site 1179773021353 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1179773021354 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1179773021355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1179773021356 active site 1179773021357 metal binding site [ion binding]; metal-binding site 1179773021358 active site 1179773021359 metal binding site [ion binding]; metal-binding site 1179773021360 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1179773021361 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1179773021362 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1179773021363 heme-binding site [chemical binding]; other site 1179773021364 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1179773021365 FAD binding pocket [chemical binding]; other site 1179773021366 FAD binding motif [chemical binding]; other site 1179773021367 phosphate binding motif [ion binding]; other site 1179773021368 beta-alpha-beta structure motif; other site 1179773021369 NAD binding pocket [chemical binding]; other site 1179773021370 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1179773021371 DNA binding residues [nucleotide binding] 1179773021372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773021373 putative dimer interface [polypeptide binding]; other site 1179773021374 chaperone protein DnaJ; Provisional; Region: PRK14295 1179773021375 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1179773021376 HSP70 interaction site [polypeptide binding]; other site 1179773021377 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1179773021378 Zn binding sites [ion binding]; other site 1179773021379 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1179773021380 dimer interface [polypeptide binding]; other site 1179773021381 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1179773021382 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1179773021383 dimer interface [polypeptide binding]; other site 1179773021384 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1179773021385 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1179773021386 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1179773021387 nucleotide binding site [chemical binding]; other site 1179773021388 NEF interaction site [polypeptide binding]; other site 1179773021389 SBD interface [polypeptide binding]; other site 1179773021390 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1179773021391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1179773021392 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1179773021393 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1179773021394 4Fe-4S binding domain; Region: Fer4; pfam00037 1179773021395 Cysteine-rich domain; Region: CCG; pfam02754 1179773021396 Cysteine-rich domain; Region: CCG; pfam02754 1179773021397 Membrane protein of unknown function; Region: DUF360; pfam04020 1179773021398 Cation efflux family; Region: Cation_efflux; pfam01545 1179773021399 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1179773021400 trimer interface [polypeptide binding]; other site 1179773021401 active site 1179773021402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1179773021403 putative active site [active] 1179773021404 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1179773021405 Fic/DOC family; Region: Fic; cl00960 1179773021406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1179773021407 MarR family; Region: MarR; pfam01047 1179773021408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773021409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773021410 DNA binding residues [nucleotide binding] 1179773021411 dimerization interface [polypeptide binding]; other site 1179773021412 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1179773021413 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1179773021414 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1179773021415 FAD binding site [chemical binding]; other site 1179773021416 substrate binding site [chemical binding]; other site 1179773021417 catalytic residues [active] 1179773021418 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1179773021419 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1179773021420 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1179773021421 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1179773021422 VanW like protein; Region: VanW; pfam04294 1179773021423 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1179773021424 oligomerisation interface [polypeptide binding]; other site 1179773021425 mobile loop; other site 1179773021426 roof hairpin; other site 1179773021427 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1179773021428 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773021429 NHL repeat; Region: NHL; pfam01436 1179773021430 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1179773021431 DNA binding residues [nucleotide binding] 1179773021432 PIN domain; Region: PIN_3; pfam13470 1179773021433 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1179773021434 putative active site [active] 1179773021435 AAA ATPase domain; Region: AAA_16; pfam13191 1179773021436 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1179773021437 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1179773021438 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1179773021439 dimer interface [polypeptide binding]; other site 1179773021440 active site 1179773021441 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1179773021442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021443 NAD(P) binding site [chemical binding]; other site 1179773021444 active site 1179773021445 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773021446 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1179773021447 active site 2 [active] 1179773021448 active site 1 [active] 1179773021449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773021450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773021451 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1179773021452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1179773021453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1179773021454 active site 1179773021455 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1179773021456 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1179773021457 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1179773021458 DNA binding residues [nucleotide binding] 1179773021459 dimer interface [polypeptide binding]; other site 1179773021460 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1179773021461 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1179773021462 E3 interaction surface; other site 1179773021463 lipoyl attachment site [posttranslational modification]; other site 1179773021464 e3 binding domain; Region: E3_binding; pfam02817 1179773021465 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1179773021466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1179773021467 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1179773021468 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1179773021469 alpha subunit interface [polypeptide binding]; other site 1179773021470 TPP binding site [chemical binding]; other site 1179773021471 heterodimer interface [polypeptide binding]; other site 1179773021472 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1179773021473 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1179773021474 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1179773021475 TPP-binding site [chemical binding]; other site 1179773021476 tetramer interface [polypeptide binding]; other site 1179773021477 heterodimer interface [polypeptide binding]; other site 1179773021478 phosphorylation loop region [posttranslational modification] 1179773021479 hypothetical protein; Provisional; Region: PRK07907 1179773021480 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1179773021481 metal binding site [ion binding]; metal-binding site 1179773021482 putative dimer interface [polypeptide binding]; other site 1179773021483 alpha-glucosidase; Provisional; Region: PRK10137 1179773021484 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1179773021485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1179773021486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1179773021487 substrate binding pocket [chemical binding]; other site 1179773021488 membrane-bound complex binding site; other site 1179773021489 hinge residues; other site 1179773021490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1179773021491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1179773021492 ABC-ATPase subunit interface; other site 1179773021493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1179773021494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1179773021495 Walker A/P-loop; other site 1179773021496 ATP binding site [chemical binding]; other site 1179773021497 Q-loop/lid; other site 1179773021498 ABC transporter signature motif; other site 1179773021499 Walker B; other site 1179773021500 D-loop; other site 1179773021501 H-loop/switch region; other site 1179773021502 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1179773021503 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1179773021504 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1179773021505 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1179773021506 nucleotide binding site [chemical binding]; other site 1179773021507 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1179773021508 Na binding site [ion binding]; other site 1179773021509 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1179773021510 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1179773021511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773021512 DNA-binding site [nucleotide binding]; DNA binding site 1179773021513 FCD domain; Region: FCD; pfam07729 1179773021514 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1179773021515 putative substrate binding pocket [chemical binding]; other site 1179773021516 AB domain interface; other site 1179773021517 Septum formation; Region: Septum_form; pfam13845 1179773021518 Septum formation; Region: Septum_form; pfam13845 1179773021519 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1179773021520 active site 1179773021521 substrate-binding site [chemical binding]; other site 1179773021522 metal-binding site [ion binding] 1179773021523 GTP binding site [chemical binding]; other site 1179773021524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1179773021525 DNA-binding site [nucleotide binding]; DNA binding site 1179773021526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773021527 sequence-specific DNA binding site [nucleotide binding]; other site 1179773021528 salt bridge; other site 1179773021529 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021530 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021531 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773021532 Dynamin family; Region: Dynamin_N; pfam00350 1179773021533 G1 box; other site 1179773021534 GTP/Mg2+ binding site [chemical binding]; other site 1179773021535 G2 box; other site 1179773021536 Switch I region; other site 1179773021537 G3 box; other site 1179773021538 Switch II region; other site 1179773021539 G4 box; other site 1179773021540 G5 box; other site 1179773021541 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1179773021542 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1179773021543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1179773021544 G1 box; other site 1179773021545 GTP/Mg2+ binding site [chemical binding]; other site 1179773021546 G2 box; other site 1179773021547 Switch I region; other site 1179773021548 G3 box; other site 1179773021549 Switch II region; other site 1179773021550 G4 box; other site 1179773021551 G5 box; other site 1179773021552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1179773021553 Histidine kinase; Region: HisKA_3; pfam07730 1179773021554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773021555 ATP binding site [chemical binding]; other site 1179773021556 Mg2+ binding site [ion binding]; other site 1179773021557 G-X-G motif; other site 1179773021558 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773021559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773021560 active site 1179773021561 phosphorylation site [posttranslational modification] 1179773021562 intermolecular recognition site; other site 1179773021563 dimerization interface [polypeptide binding]; other site 1179773021564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773021565 DNA binding residues [nucleotide binding] 1179773021566 dimerization interface [polypeptide binding]; other site 1179773021567 short chain dehydrogenase; Provisional; Region: PRK08303 1179773021568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021569 NAD(P) binding site [chemical binding]; other site 1179773021570 active site 1179773021571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773021572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773021573 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1179773021574 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1179773021575 FtsI repressor; Provisional; Region: PRK10883 1179773021576 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1179773021577 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1179773021578 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1179773021579 Histidine kinase; Region: HisKA_3; pfam07730 1179773021580 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1179773021581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773021582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773021583 active site 1179773021584 phosphorylation site [posttranslational modification] 1179773021585 intermolecular recognition site; other site 1179773021586 dimerization interface [polypeptide binding]; other site 1179773021587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773021588 DNA binding residues [nucleotide binding] 1179773021589 dimerization interface [polypeptide binding]; other site 1179773021590 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1179773021591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021592 DNA binding residues [nucleotide binding] 1179773021593 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1179773021594 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773021595 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1179773021596 Walker A/P-loop; other site 1179773021597 ATP binding site [chemical binding]; other site 1179773021598 Q-loop/lid; other site 1179773021599 ABC transporter signature motif; other site 1179773021600 Walker B; other site 1179773021601 D-loop; other site 1179773021602 H-loop/switch region; other site 1179773021603 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1179773021604 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1179773021605 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1179773021606 Walker A/P-loop; other site 1179773021607 ATP binding site [chemical binding]; other site 1179773021608 Q-loop/lid; other site 1179773021609 ABC transporter signature motif; other site 1179773021610 Walker B; other site 1179773021611 D-loop; other site 1179773021612 H-loop/switch region; other site 1179773021613 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1179773021614 active site 1179773021615 catalytic residues [active] 1179773021616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773021617 S-adenosylmethionine binding site [chemical binding]; other site 1179773021618 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 1179773021619 active site 1179773021620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773021621 Histidine kinase; Region: HisKA_3; pfam07730 1179773021622 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1179773021623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1179773021624 active site 1179773021625 short chain dehydrogenase; Provisional; Region: PRK08219 1179773021626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1179773021627 NAD(P) binding site [chemical binding]; other site 1179773021628 active site 1179773021629 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1179773021630 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1179773021631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1179773021632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1179773021633 putative substrate translocation pore; other site 1179773021634 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1179773021635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1179773021636 motif II; other site 1179773021637 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1179773021638 classical (c) SDRs; Region: SDR_c; cd05233 1179773021639 NAD(P) binding site [chemical binding]; other site 1179773021640 active site 1179773021641 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1179773021642 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1179773021643 Predicted transcriptional regulators [Transcription]; Region: COG1695 1179773021644 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1179773021645 Transglycosylase; Region: Transgly; pfam00912 1179773021646 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1179773021647 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1179773021648 Predicted integral membrane protein [Function unknown]; Region: COG5650 1179773021649 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1179773021650 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1179773021651 putative sugar binding sites [chemical binding]; other site 1179773021652 Q-X-W motif; other site 1179773021653 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1179773021654 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1179773021655 active site 1179773021656 oxyanion hole [active] 1179773021657 catalytic triad [active] 1179773021658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1179773021659 S-adenosylmethionine binding site [chemical binding]; other site 1179773021660 Predicted integral membrane protein [Function unknown]; Region: COG5650 1179773021661 endonuclease IV; Provisional; Region: PRK01060 1179773021662 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1179773021663 AP (apurinic/apyrimidinic) site pocket; other site 1179773021664 DNA interaction; other site 1179773021665 Metal-binding active site; metal-binding site 1179773021666 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1179773021667 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1179773021668 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1179773021669 dimer interface [polypeptide binding]; other site 1179773021670 ssDNA binding site [nucleotide binding]; other site 1179773021671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1179773021672 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1179773021673 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1179773021674 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1179773021675 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1179773021676 replicative DNA helicase; Region: DnaB; TIGR00665 1179773021677 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1179773021678 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1179773021679 Walker A motif; other site 1179773021680 ATP binding site [chemical binding]; other site 1179773021681 Walker B motif; other site 1179773021682 DNA binding loops [nucleotide binding] 1179773021683 Predicted transcriptional regulator [Transcription]; Region: COG2378 1179773021684 HTH domain; Region: HTH_11; pfam08279 1179773021685 WYL domain; Region: WYL; pfam13280 1179773021686 SnoaL-like domain; Region: SnoaL_2; pfam12680 1179773021687 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1179773021688 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1179773021689 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1179773021690 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1179773021691 Cytochrome P450; Region: p450; cl12078 1179773021692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773021693 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1179773021694 Walker A/P-loop; other site 1179773021695 ATP binding site [chemical binding]; other site 1179773021696 Q-loop/lid; other site 1179773021697 ABC transporter signature motif; other site 1179773021698 Walker B; other site 1179773021699 D-loop; other site 1179773021700 H-loop/switch region; other site 1179773021701 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1179773021702 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1179773021703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1179773021704 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1179773021705 Predicted ATPase [General function prediction only]; Region: COG3903 1179773021706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773021707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773021708 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1179773021709 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1179773021710 active site 1179773021711 catalytic site [active] 1179773021712 substrate binding site [chemical binding]; other site 1179773021713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773021714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773021715 metal binding site [ion binding]; metal-binding site 1179773021716 active site 1179773021717 I-site; other site 1179773021718 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1179773021719 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1179773021720 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1179773021721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1179773021722 metal binding site [ion binding]; metal-binding site 1179773021723 active site 1179773021724 I-site; other site 1179773021725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1179773021726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1179773021727 ATP binding site [chemical binding]; other site 1179773021728 Mg2+ binding site [ion binding]; other site 1179773021729 G-X-G motif; other site 1179773021730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773021731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1179773021732 active site 1179773021733 phosphorylation site [posttranslational modification] 1179773021734 intermolecular recognition site; other site 1179773021735 dimerization interface [polypeptide binding]; other site 1179773021736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773021737 DNA binding residues [nucleotide binding] 1179773021738 dimerization interface [polypeptide binding]; other site 1179773021739 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1179773021740 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1179773021741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1179773021742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773021743 non-specific DNA binding site [nucleotide binding]; other site 1179773021744 salt bridge; other site 1179773021745 sequence-specific DNA binding site [nucleotide binding]; other site 1179773021746 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021747 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1179773021748 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1179773021749 putative NAD(P) binding site [chemical binding]; other site 1179773021750 putative active site [active] 1179773021751 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1179773021752 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1179773021753 NAD(P) binding site [chemical binding]; other site 1179773021754 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1179773021755 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1179773021756 substrate-cofactor binding pocket; other site 1179773021757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773021758 catalytic residue [active] 1179773021759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1179773021760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773021761 dimerization interface [polypeptide binding]; other site 1179773021762 putative DNA binding site [nucleotide binding]; other site 1179773021763 putative Zn2+ binding site [ion binding]; other site 1179773021764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1179773021765 putative dimerization interface [polypeptide binding]; other site 1179773021766 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1179773021767 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1179773021768 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1179773021769 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1179773021770 PQQ-like domain; Region: PQQ_2; pfam13360 1179773021771 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1179773021772 active site 1179773021773 Isochorismatase family; Region: Isochorismatase; pfam00857 1179773021774 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1179773021775 catalytic triad [active] 1179773021776 conserved cis-peptide bond; other site 1179773021777 D-ribose pyranase; Provisional; Region: PRK11797 1179773021778 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1179773021779 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1179773021780 substrate binding site [chemical binding]; other site 1179773021781 ATP binding site [chemical binding]; other site 1179773021782 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1179773021783 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1179773021784 ligand binding site [chemical binding]; other site 1179773021785 dimerization interface [polypeptide binding]; other site 1179773021786 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1179773021787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1179773021788 TM-ABC transporter signature motif; other site 1179773021789 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1179773021790 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1179773021791 Walker A/P-loop; other site 1179773021792 ATP binding site [chemical binding]; other site 1179773021793 Q-loop/lid; other site 1179773021794 ABC transporter signature motif; other site 1179773021795 Walker B; other site 1179773021796 D-loop; other site 1179773021797 H-loop/switch region; other site 1179773021798 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1179773021799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1179773021800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1179773021801 DNA binding site [nucleotide binding] 1179773021802 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1179773021803 ligand binding site [chemical binding]; other site 1179773021804 dimerization interface [polypeptide binding]; other site 1179773021805 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1179773021806 PQQ-like domain; Region: PQQ_2; pfam13360 1179773021807 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1179773021808 MMPL family; Region: MMPL; pfam03176 1179773021809 MMPL family; Region: MMPL; pfam03176 1179773021810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1179773021811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1179773021812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773021813 non-specific DNA binding site [nucleotide binding]; other site 1179773021814 salt bridge; other site 1179773021815 sequence-specific DNA binding site [nucleotide binding]; other site 1179773021816 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021817 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1179773021818 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773021819 active site 1179773021820 HIGH motif; other site 1179773021821 nucleotide binding site [chemical binding]; other site 1179773021822 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1179773021823 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773021824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1179773021825 active site 1179773021826 KMSKS motif; other site 1179773021827 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1179773021828 tRNA binding surface [nucleotide binding]; other site 1179773021829 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1179773021830 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1179773021831 hypothetical protein; Validated; Region: PRK00228 1179773021832 H+ Antiporter protein; Region: 2A0121; TIGR00900 1179773021833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1179773021834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1179773021835 DNA binding residues [nucleotide binding] 1179773021836 dimerization interface [polypeptide binding]; other site 1179773021837 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1179773021838 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1179773021839 active site 1179773021840 NTP binding site [chemical binding]; other site 1179773021841 metal binding triad [ion binding]; metal-binding site 1179773021842 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1179773021843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1179773021844 Zn2+ binding site [ion binding]; other site 1179773021845 Mg2+ binding site [ion binding]; other site 1179773021846 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1179773021847 active site 1179773021848 Ap6A binding site [chemical binding]; other site 1179773021849 nudix motif; other site 1179773021850 metal binding site [ion binding]; metal-binding site 1179773021851 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1179773021852 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1179773021853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1179773021854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1179773021855 DNA binding residues [nucleotide binding] 1179773021856 putative anti-sigmaE protein; Provisional; Region: PRK13920 1179773021857 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1179773021858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1179773021859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1179773021860 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1179773021861 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1179773021862 catalytic residues [active] 1179773021863 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1179773021864 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773021865 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1179773021866 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1179773021867 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1179773021868 active site 1179773021869 metal binding site [ion binding]; metal-binding site 1179773021870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1179773021871 non-specific DNA binding site [nucleotide binding]; other site 1179773021872 salt bridge; other site 1179773021873 sequence-specific DNA binding site [nucleotide binding]; other site 1179773021874 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1179773021875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773021876 AAA domain; Region: AAA_21; pfam13304 1179773021877 Walker A/P-loop; other site 1179773021878 ATP binding site [chemical binding]; other site 1179773021879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1179773021880 Walker B; other site 1179773021881 D-loop; other site 1179773021882 H-loop/switch region; other site 1179773021883 RloB-like protein; Region: RloB; pfam13707 1179773021884 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1179773021885 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1179773021886 putative active site [active] 1179773021887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1179773021888 dimerization interface [polypeptide binding]; other site 1179773021889 putative DNA binding site [nucleotide binding]; other site 1179773021890 putative Zn2+ binding site [ion binding]; other site 1179773021891 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1179773021892 putative hydrophobic ligand binding site [chemical binding]; other site 1179773021893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1179773021894 Coenzyme A binding pocket [chemical binding]; other site 1179773021895 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1179773021896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1179773021897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1179773021898 homodimer interface [polypeptide binding]; other site 1179773021899 catalytic residue [active] 1179773021900 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1179773021901 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1179773021902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1179773021903 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1179773021904 ParB-like nuclease domain; Region: ParBc; pfam02195 1179773021905 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1179773021906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773021907 P-loop; other site 1179773021908 Magnesium ion binding site [ion binding]; other site 1179773021909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1179773021910 Magnesium ion binding site [ion binding]; other site 1179773021911 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1179773021912 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1179773021913 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1179773021914 nudix motif; other site 1179773021915 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1179773021916 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1179773021917 G-X-X-G motif; other site 1179773021918 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1179773021919 RxxxH motif; other site 1179773021920 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1179773021921 Haemolytic domain; Region: Haemolytic; pfam01809 1179773021922 Ribonuclease P; Region: Ribonuclease_P; cl00457 1179773021923 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399