-- dump date 20140620_042734 -- class Genbank::misc_feature -- table misc_feature_note -- id note 761659000001 CHC2 zinc finger; Region: zf-CHC2; cl17510 761659000002 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 761659000003 active site 761659000004 metal binding site [ion binding]; metal-binding site 761659000005 interdomain interaction site; other site 761659000006 D5 N terminal like; Region: D5_N; smart00885 761659000007 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 761659000008 large terminase protein; Provisional; Region: 17; PHA02533 761659000009 chromosome segregation protein; Provisional; Region: PRK03918 761659000010 ParA-like protein; Provisional; Region: PHA02518 761659000011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659000012 P-loop; other site 761659000013 Magnesium ion binding site [ion binding]; other site 761659000014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 761659000015 non-specific DNA binding site [nucleotide binding]; other site 761659000016 salt bridge; other site 761659000017 sequence-specific DNA binding site [nucleotide binding]; other site 761659000018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659000019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659000020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659000021 multiple promoter invertase; Provisional; Region: mpi; PRK13413 761659000022 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 761659000023 catalytic residues [active] 761659000024 catalytic nucleophile [active] 761659000025 Presynaptic Site I dimer interface [polypeptide binding]; other site 761659000026 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 761659000027 Synaptic Flat tetramer interface [polypeptide binding]; other site 761659000028 Synaptic Site I dimer interface [polypeptide binding]; other site 761659000029 DNA binding site [nucleotide binding] 761659000030 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659000031 DNA-binding interface [nucleotide binding]; DNA binding site 761659000032 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 761659000033 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 761659000034 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 761659000035 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 761659000036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 761659000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 761659000038 non-specific DNA binding site [nucleotide binding]; other site 761659000039 salt bridge; other site 761659000040 sequence-specific DNA binding site [nucleotide binding]; other site 761659000041 Domain of unknown function (DUF955); Region: DUF955; cl01076 761659000042 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 761659000043 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 761659000044 Part of AAA domain; Region: AAA_19; pfam13245 761659000045 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 761659000046 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 761659000047 DHH family; Region: DHH; pfam01368 761659000048 DHHA1 domain; Region: DHHA1; pfam02272 761659000049 Predicted transcriptional regulators [Transcription]; Region: COG1510 761659000050 MarR family; Region: MarR_2; pfam12802 761659000051 DEAD-like helicases superfamily; Region: DEXDc; smart00487 761659000052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659000053 ATP binding site [chemical binding]; other site 761659000054 putative Mg++ binding site [ion binding]; other site 761659000055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659000056 nucleotide binding region [chemical binding]; other site 761659000057 ATP-binding site [chemical binding]; other site 761659000058 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 761659000059 GIY-YIG motif/motif A; other site 761659000060 putative active site [active] 761659000061 putative metal binding site [ion binding]; other site 761659000062 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 761659000063 HsdM N-terminal domain; Region: HsdM_N; pfam12161 761659000064 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 761659000065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 761659000066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659000067 S-adenosylmethionine binding site [chemical binding]; other site 761659000068 Protein of unknown function DUF45; Region: DUF45; pfam01863 761659000069 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 761659000070 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 761659000071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659000072 ATP binding site [chemical binding]; other site 761659000073 putative Mg++ binding site [ion binding]; other site 761659000074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000075 ATP binding site [chemical binding]; other site 761659000076 Mg2+ binding site [ion binding]; other site 761659000077 G-X-G motif; other site 761659000078 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 761659000079 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 761659000080 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 761659000081 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 761659000082 HsdM N-terminal domain; Region: HsdM_N; pfam12161 761659000083 Methyltransferase domain; Region: Methyltransf_26; pfam13659 761659000084 ParA-like protein; Provisional; Region: PHA02518 761659000085 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659000086 P-loop; other site 761659000087 Magnesium ion binding site [ion binding]; other site 761659000088 Protein of unknown function (DUF497); Region: DUF497; pfam04365 761659000089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 761659000090 putative DNA binding site [nucleotide binding]; other site 761659000091 putative Zn2+ binding site [ion binding]; other site 761659000092 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 761659000093 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 761659000094 active site 761659000095 DNA polymerase IV; Validated; Region: PRK02406 761659000096 DNA binding site [nucleotide binding] 761659000097 Staphylococcal nuclease homologues; Region: SNc; smart00318 761659000098 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 761659000099 Catalytic site; other site 761659000100 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 761659000101 Uncharacterized conserved protein [Function unknown]; Region: COG1479 761659000102 Protein of unknown function DUF262; Region: DUF262; pfam03235 761659000103 Uncharacterized conserved protein [Function unknown]; Region: COG3472 761659000104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 761659000105 Transposase; Region: DDE_Tnp_ISL3; pfam01610 761659000106 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 761659000107 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 761659000108 catalytic residues [active] 761659000109 catalytic nucleophile [active] 761659000110 Presynaptic Site I dimer interface [polypeptide binding]; other site 761659000111 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 761659000112 Synaptic Flat tetramer interface [polypeptide binding]; other site 761659000113 Synaptic Site I dimer interface [polypeptide binding]; other site 761659000114 DNA binding site [nucleotide binding] 761659000115 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 761659000116 active site 761659000117 catalytic site [active] 761659000118 substrate binding site [chemical binding]; other site 761659000119 O-Antigen ligase; Region: Wzy_C; pfam04932 761659000120 TIGR02302 family protein; Region: aProt_lowcomp 761659000121 Excalibur calcium-binding domain; Region: Excalibur; cl05460 761659000122 ParA-like protein; Provisional; Region: PHA02518 761659000123 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659000124 P-loop; other site 761659000125 Magnesium ion binding site [ion binding]; other site 761659000126 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 761659000127 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659000128 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659000129 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 761659000130 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000131 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000132 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000133 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000134 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659000135 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000136 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000137 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 761659000138 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 761659000139 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659000140 Interdomain contacts; other site 761659000141 Cytokine receptor motif; other site 761659000142 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000143 Family description; Region: VCBS; pfam13517 761659000144 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000145 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 761659000146 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 761659000147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659000148 active site 761659000149 DNA binding site [nucleotide binding] 761659000150 Int/Topo IB signature motif; other site 761659000151 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659000152 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659000153 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659000154 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 761659000155 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659000156 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659000157 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659000158 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 761659000159 Excalibur calcium-binding domain; Region: Excalibur; cl05460 761659000160 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 761659000161 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 761659000162 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659000163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659000164 DnaA N-terminal domain; Region: DnaA_N; pfam11638 761659000165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659000166 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 761659000167 Walker A motif; other site 761659000168 ATP binding site [chemical binding]; other site 761659000169 Walker B motif; other site 761659000170 arginine finger; other site 761659000171 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 761659000172 DnaA box-binding interface [nucleotide binding]; other site 761659000173 DNA polymerase III subunit beta; Validated; Region: PRK05643 761659000174 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 761659000175 putative DNA binding surface [nucleotide binding]; other site 761659000176 dimer interface [polypeptide binding]; other site 761659000177 beta-clamp/clamp loader binding surface; other site 761659000178 beta-clamp/translesion DNA polymerase binding surface; other site 761659000179 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 761659000180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659000181 DNA binding residues [nucleotide binding] 761659000182 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 761659000183 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 761659000184 Cu(I) binding site [ion binding]; other site 761659000185 short chain dehydrogenase; Provisional; Region: PRK06197 761659000186 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 761659000187 putative NAD(P) binding site [chemical binding]; other site 761659000188 active site 761659000189 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 761659000190 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 761659000191 substrate binding site [chemical binding]; other site 761659000192 hexamer interface [polypeptide binding]; other site 761659000193 metal binding site [ion binding]; metal-binding site 761659000194 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 761659000195 putative homodimer interface [polypeptide binding]; other site 761659000196 putative homotetramer interface [polypeptide binding]; other site 761659000197 putative allosteric switch controlling residues; other site 761659000198 putative metal binding site [ion binding]; other site 761659000199 putative homodimer-homodimer interface [polypeptide binding]; other site 761659000200 Preprotein translocase subunit; Region: YajC; pfam02699 761659000201 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 761659000202 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 761659000203 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 761659000204 dimerization interface [polypeptide binding]; other site 761659000205 active site 761659000206 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 761659000207 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 761659000208 Competence protein; Region: Competence; pfam03772 761659000209 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 761659000210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 761659000211 transcription antitermination factor NusB; Region: nusB; TIGR01951 761659000212 putative RNA binding site [nucleotide binding]; other site 761659000213 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 761659000214 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 761659000215 active site 761659000216 metal binding site [ion binding]; metal-binding site 761659000217 GTP-binding protein YchF; Reviewed; Region: PRK09601 761659000218 YchF GTPase; Region: YchF; cd01900 761659000219 G1 box; other site 761659000220 GTP/Mg2+ binding site [chemical binding]; other site 761659000221 Switch I region; other site 761659000222 G2 box; other site 761659000223 Switch II region; other site 761659000224 G3 box; other site 761659000225 G4 box; other site 761659000226 G5 box; other site 761659000227 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 761659000228 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 761659000229 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659000230 FtsX-like permease family; Region: FtsX; pfam02687 761659000231 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 761659000232 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 761659000233 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 761659000234 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 761659000235 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 761659000236 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 761659000237 Walker A motif; other site 761659000238 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 761659000239 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 761659000240 protein-splicing catalytic site; other site 761659000241 thioester formation/cholesterol transfer; other site 761659000242 replicative DNA helicase; Region: DnaB; TIGR00665 761659000243 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 761659000244 ATP binding site [chemical binding]; other site 761659000245 Walker B motif; other site 761659000246 DNA binding loops [nucleotide binding] 761659000247 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 761659000248 Fe-S cluster binding site [ion binding]; other site 761659000249 active site 761659000250 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 761659000251 Flavoprotein; Region: Flavoprotein; pfam02441 761659000252 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 761659000253 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 761659000254 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 761659000255 catalytic site [active] 761659000256 G-X2-G-X-G-K; other site 761659000257 hypothetical protein; Provisional; Region: PRK11820 761659000258 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 761659000259 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 761659000260 ribosome recycling factor; Reviewed; Region: frr; PRK00083 761659000261 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 761659000262 hinge region; other site 761659000263 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 761659000264 putative nucleotide binding site [chemical binding]; other site 761659000265 uridine monophosphate binding site [chemical binding]; other site 761659000266 homohexameric interface [polypeptide binding]; other site 761659000267 elongation factor Ts; Provisional; Region: tsf; PRK09377 761659000268 UBA/TS-N domain; Region: UBA; pfam00627 761659000269 Elongation factor TS; Region: EF_TS; pfam00889 761659000270 Elongation factor TS; Region: EF_TS; pfam00889 761659000271 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 761659000272 rRNA interaction site [nucleotide binding]; other site 761659000273 S8 interaction site; other site 761659000274 putative laminin-1 binding site; other site 761659000275 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 761659000276 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 761659000277 23S rRNA interface [nucleotide binding]; other site 761659000278 L3 interface [polypeptide binding]; other site 761659000279 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 761659000280 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 761659000281 putative phosphate acyltransferase; Provisional; Region: PRK05331 761659000282 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 761659000283 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 761659000284 dimer interface [polypeptide binding]; other site 761659000285 active site 761659000286 CoA binding pocket [chemical binding]; other site 761659000287 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 761659000288 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 761659000289 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 761659000290 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 761659000291 NAD(P) binding site [chemical binding]; other site 761659000292 homotetramer interface [polypeptide binding]; other site 761659000293 homodimer interface [polypeptide binding]; other site 761659000294 active site 761659000295 helicase 45; Provisional; Region: PTZ00424 761659000296 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 761659000297 ATP binding site [chemical binding]; other site 761659000298 Mg++ binding site [ion binding]; other site 761659000299 motif III; other site 761659000300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659000301 nucleotide binding region [chemical binding]; other site 761659000302 ATP-binding site [chemical binding]; other site 761659000303 Predicted membrane protein [Function unknown]; Region: COG2259 761659000304 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 761659000305 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 761659000306 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 761659000307 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659000308 FOG: PKD repeat [General function prediction only]; Region: COG3291 761659000309 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659000310 Sporulation related domain; Region: SPOR; pfam05036 761659000311 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 761659000312 ribonuclease P; Reviewed; Region: rnpA; PRK01903 761659000313 membrane protein insertase; Provisional; Region: PRK01318 761659000314 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 761659000315 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 761659000316 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 761659000317 trmE is a tRNA modification GTPase; Region: trmE; cd04164 761659000318 G1 box; other site 761659000319 GTP/Mg2+ binding site [chemical binding]; other site 761659000320 Switch I region; other site 761659000321 G2 box; other site 761659000322 Switch II region; other site 761659000323 G3 box; other site 761659000324 G4 box; other site 761659000325 G5 box; other site 761659000326 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 761659000327 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 761659000328 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 761659000329 active site 761659000330 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 761659000331 active site 2 [active] 761659000332 active site 1 [active] 761659000333 Double zinc ribbon; Region: DZR; pfam12773 761659000334 Helix-turn-helix domain; Region: HTH_28; pfam13518 761659000335 Winged helix-turn helix; Region: HTH_29; pfam13551 761659000336 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 761659000337 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 761659000338 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 761659000339 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 761659000340 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 761659000341 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659000342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 761659000343 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659000344 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 761659000345 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 761659000346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659000347 ATP binding site [chemical binding]; other site 761659000348 putative Mg++ binding site [ion binding]; other site 761659000349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659000350 nucleotide binding region [chemical binding]; other site 761659000351 ATP-binding site [chemical binding]; other site 761659000352 TRCF domain; Region: TRCF; pfam03461 761659000353 HEPN domain; Region: HEPN; cl00824 761659000354 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 761659000355 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 761659000356 putative active site [active] 761659000357 CHAT domain; Region: CHAT; pfam12770 761659000358 recombination protein F; Reviewed; Region: recF; PRK00064 761659000359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659000360 Walker A/P-loop; other site 761659000361 ATP binding site [chemical binding]; other site 761659000362 Q-loop/lid; other site 761659000363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659000364 ABC transporter signature motif; other site 761659000365 Walker B; other site 761659000366 D-loop; other site 761659000367 H-loop/switch region; other site 761659000368 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 761659000369 Peptidase family M48; Region: Peptidase_M48; pfam01435 761659000370 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 761659000371 dimer interaction site [polypeptide binding]; other site 761659000372 substrate-binding tunnel; other site 761659000373 active site 761659000374 catalytic site [active] 761659000375 substrate binding site [chemical binding]; other site 761659000376 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 761659000377 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 761659000378 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 761659000379 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659000380 active site 761659000381 DNA binding site [nucleotide binding] 761659000382 Int/Topo IB signature motif; other site 761659000383 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 761659000384 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 761659000385 putative active site [active] 761659000386 homotetrameric interface [polypeptide binding]; other site 761659000387 metal binding site [ion binding]; metal-binding site 761659000388 Abortive infection C-terminus; Region: Abi_C; pfam14355 761659000389 PemK-like protein; Region: PemK; cl00995 761659000390 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 761659000391 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 761659000392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000394 dimer interface [polypeptide binding]; other site 761659000395 phosphorylation site [posttranslational modification] 761659000396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000397 ATP binding site [chemical binding]; other site 761659000398 Mg2+ binding site [ion binding]; other site 761659000399 G-X-G motif; other site 761659000400 Response regulator receiver domain; Region: Response_reg; pfam00072 761659000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659000402 active site 761659000403 phosphorylation site [posttranslational modification] 761659000404 intermolecular recognition site; other site 761659000405 dimerization interface [polypeptide binding]; other site 761659000406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 761659000407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659000408 mercuric reductase; Validated; Region: PRK06370 761659000409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659000410 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 761659000411 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 761659000412 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 761659000413 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 761659000414 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 761659000415 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 761659000416 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 761659000417 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 761659000418 putative active site [active] 761659000419 catalytic residue [active] 761659000420 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 761659000421 active site 761659000422 dimer interface [polypeptide binding]; other site 761659000423 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 761659000424 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659000425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659000426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659000427 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 761659000428 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 761659000429 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659000430 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 761659000431 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659000432 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659000433 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 761659000434 GAF domain; Region: GAF_2; pfam13185 761659000435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000437 dimer interface [polypeptide binding]; other site 761659000438 phosphorylation site [posttranslational modification] 761659000439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000440 ATP binding site [chemical binding]; other site 761659000441 Mg2+ binding site [ion binding]; other site 761659000442 G-X-G motif; other site 761659000443 PAS fold; Region: PAS_4; pfam08448 761659000444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000445 putative active site [active] 761659000446 heme pocket [chemical binding]; other site 761659000447 PAS domain; Region: PAS_9; pfam13426 761659000448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000449 putative active site [active] 761659000450 heme pocket [chemical binding]; other site 761659000451 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 761659000452 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659000453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000455 dimer interface [polypeptide binding]; other site 761659000456 phosphorylation site [posttranslational modification] 761659000457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000458 ATP binding site [chemical binding]; other site 761659000459 Mg2+ binding site [ion binding]; other site 761659000460 G-X-G motif; other site 761659000461 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 761659000462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 761659000463 4Fe-4S binding domain; Region: Fer4_5; pfam12801 761659000464 4Fe-4S binding domain; Region: Fer4_5; pfam12801 761659000465 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 761659000466 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 761659000467 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 761659000468 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 761659000469 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 761659000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000471 ATP binding site [chemical binding]; other site 761659000472 Mg2+ binding site [ion binding]; other site 761659000473 G-X-G motif; other site 761659000474 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 761659000475 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 761659000476 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 761659000477 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 761659000478 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659000479 GAF domain; Region: GAF; pfam01590 761659000480 PAS domain; Region: PAS_9; pfam13426 761659000481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000482 putative active site [active] 761659000483 heme pocket [chemical binding]; other site 761659000484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000485 PAS domain; Region: PAS_9; pfam13426 761659000486 putative active site [active] 761659000487 heme pocket [chemical binding]; other site 761659000488 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659000489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000490 putative active site [active] 761659000491 heme pocket [chemical binding]; other site 761659000492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000493 putative active site [active] 761659000494 heme pocket [chemical binding]; other site 761659000495 GAF domain; Region: GAF_3; pfam13492 761659000496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000498 dimer interface [polypeptide binding]; other site 761659000499 phosphorylation site [posttranslational modification] 761659000500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000501 ATP binding site [chemical binding]; other site 761659000502 Mg2+ binding site [ion binding]; other site 761659000503 G-X-G motif; other site 761659000504 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659000505 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 761659000506 Repair protein; Region: Repair_PSII; pfam04536 761659000507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659000508 TPR repeat; Region: TPR_11; pfam13414 761659000509 binding surface 761659000510 TPR motif; other site 761659000511 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 761659000512 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 761659000513 Peptidase family M48; Region: Peptidase_M48; cl12018 761659000514 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 761659000515 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 761659000516 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 761659000517 Cu(I) binding site [ion binding]; other site 761659000518 Phospholipid methyltransferase; Region: PEMT; cl17370 761659000519 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 761659000520 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 761659000521 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 761659000522 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 761659000523 Two component regulator propeller; Region: Reg_prop; pfam07494 761659000524 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 761659000525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000527 dimer interface [polypeptide binding]; other site 761659000528 phosphorylation site [posttranslational modification] 761659000529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000530 ATP binding site [chemical binding]; other site 761659000531 Mg2+ binding site [ion binding]; other site 761659000532 G-X-G motif; other site 761659000533 Response regulator receiver domain; Region: Response_reg; pfam00072 761659000534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659000535 active site 761659000536 phosphorylation site [posttranslational modification] 761659000537 intermolecular recognition site; other site 761659000538 dimerization interface [polypeptide binding]; other site 761659000539 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 761659000540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659000541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659000542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 761659000543 NlpC/P60 family; Region: NLPC_P60; pfam00877 761659000544 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659000545 Bor protein; Region: Lambda_Bor; pfam06291 761659000546 IPT/TIG domain; Region: TIG; pfam01833 761659000547 Family description; Region: VCBS; pfam13517 761659000548 Family description; Region: VCBS; pfam13517 761659000549 Family description; Region: VCBS; pfam13517 761659000550 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659000551 Interdomain contacts; other site 761659000552 IPT/TIG domain; Region: TIG; pfam01833 761659000553 Family description; Region: VCBS; pfam13517 761659000554 Family description; Region: VCBS; pfam13517 761659000555 Family description; Region: VCBS; pfam13517 761659000556 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659000557 Interdomain contacts; other site 761659000558 Cytokine receptor motif; other site 761659000559 Family description; Region: VCBS; pfam13517 761659000560 Family description; Region: VCBS; pfam13517 761659000561 Family description; Region: VCBS; pfam13517 761659000562 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659000563 Interdomain contacts; other site 761659000564 Cytokine receptor motif; other site 761659000565 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000566 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659000567 Interdomain contacts; other site 761659000568 Cytokine receptor motif; other site 761659000569 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 761659000570 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 761659000571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659000572 dimerization interface [polypeptide binding]; other site 761659000573 putative DNA binding site [nucleotide binding]; other site 761659000574 putative Zn2+ binding site [ion binding]; other site 761659000575 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 761659000576 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 761659000577 VCBS repeat; Region: VCBS_repeat; TIGR01965 761659000578 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000579 acyl-coenzyme A oxidase; Region: PLN02526 761659000580 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 761659000581 active site 761659000582 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659000583 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659000584 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659000585 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 761659000586 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 761659000587 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 761659000588 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 761659000589 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659000590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000592 dimer interface [polypeptide binding]; other site 761659000593 phosphorylation site [posttranslational modification] 761659000594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000595 ATP binding site [chemical binding]; other site 761659000596 G-X-G motif; other site 761659000597 TraB family; Region: TraB; pfam01963 761659000598 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 761659000599 dimer interface [polypeptide binding]; other site 761659000600 putative radical transfer pathway; other site 761659000601 diiron center [ion binding]; other site 761659000602 tyrosyl radical; other site 761659000603 ribonucleoside-diphosphate reductase, alpha chain; Region: NrdE-prime; TIGR02510 761659000604 Class I ribonucleotide reductase; Region: RNR_I; cd01679 761659000605 active site 761659000606 dimer interface [polypeptide binding]; other site 761659000607 catalytic residues [active] 761659000608 effector binding site; other site 761659000609 R2 peptide binding site; other site 761659000610 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 761659000611 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 761659000612 FMN reductase; Validated; Region: fre; PRK08051 761659000613 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 761659000614 FAD binding pocket [chemical binding]; other site 761659000615 conserved FAD binding motif [chemical binding]; other site 761659000616 phosphate binding motif [ion binding]; other site 761659000617 beta-alpha-beta structure motif; other site 761659000618 NAD binding pocket [chemical binding]; other site 761659000619 Predicted transcriptional regulator [Transcription]; Region: COG2345 761659000620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659000621 dimerization interface [polypeptide binding]; other site 761659000622 putative DNA binding site [nucleotide binding]; other site 761659000623 putative Zn2+ binding site [ion binding]; other site 761659000624 HDOD domain; Region: HDOD; pfam08668 761659000625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000626 PAS domain; Region: PAS_9; pfam13426 761659000627 putative active site [active] 761659000628 heme pocket [chemical binding]; other site 761659000629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659000630 dimerization interface [polypeptide binding]; other site 761659000631 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659000632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659000633 dimer interface [polypeptide binding]; other site 761659000634 putative CheW interface [polypeptide binding]; other site 761659000635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659000636 Ligand Binding Site [chemical binding]; other site 761659000637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659000638 Ligand Binding Site [chemical binding]; other site 761659000639 PAS fold; Region: PAS_3; pfam08447 761659000640 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659000641 GAF domain; Region: GAF; pfam01590 761659000642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659000643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000644 dimer interface [polypeptide binding]; other site 761659000645 phosphorylation site [posttranslational modification] 761659000646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000647 ATP binding site [chemical binding]; other site 761659000648 Mg2+ binding site [ion binding]; other site 761659000649 G-X-G motif; other site 761659000650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659000651 putative substrate translocation pore; other site 761659000652 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 761659000653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000654 PAS domain; Region: PAS_9; pfam13426 761659000655 putative active site [active] 761659000656 heme pocket [chemical binding]; other site 761659000657 PAS fold; Region: PAS_3; pfam08447 761659000658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000659 putative active site [active] 761659000660 heme pocket [chemical binding]; other site 761659000661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000662 putative active site [active] 761659000663 PAS fold; Region: PAS_3; pfam08447 761659000664 heme pocket [chemical binding]; other site 761659000665 PAS domain S-box; Region: sensory_box; TIGR00229 761659000666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000667 putative active site [active] 761659000668 heme pocket [chemical binding]; other site 761659000669 PAS domain S-box; Region: sensory_box; TIGR00229 761659000670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000671 putative active site [active] 761659000672 heme pocket [chemical binding]; other site 761659000673 PAS fold; Region: PAS_3; pfam08447 761659000674 PAS fold; Region: PAS_4; pfam08448 761659000675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000676 dimer interface [polypeptide binding]; other site 761659000677 phosphorylation site [posttranslational modification] 761659000678 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 761659000679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000680 ATP binding site [chemical binding]; other site 761659000681 Mg2+ binding site [ion binding]; other site 761659000682 G-X-G motif; other site 761659000683 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659000684 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 761659000685 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 761659000686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659000687 dimer interface [polypeptide binding]; other site 761659000688 putative CheW interface [polypeptide binding]; other site 761659000689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 761659000690 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 761659000691 Walker A/P-loop; other site 761659000692 ATP binding site [chemical binding]; other site 761659000693 Q-loop/lid; other site 761659000694 ABC transporter signature motif; other site 761659000695 Walker B; other site 761659000696 D-loop; other site 761659000697 H-loop/switch region; other site 761659000698 CAAX protease self-immunity; Region: Abi; pfam02517 761659000699 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 761659000700 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 761659000701 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 761659000702 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 761659000703 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 761659000704 catalytic motif [active] 761659000705 Catalytic residue [active] 761659000706 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 761659000707 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659000708 catalytic residues [active] 761659000709 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 761659000710 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 761659000711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659000712 dimer interface [polypeptide binding]; other site 761659000713 putative CheW interface [polypeptide binding]; other site 761659000714 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 761659000715 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659000716 dimerization interface [polypeptide binding]; other site 761659000717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659000718 dimer interface [polypeptide binding]; other site 761659000719 putative CheW interface [polypeptide binding]; other site 761659000720 PKD domain; Region: PKD; pfam00801 761659000721 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 761659000722 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 761659000723 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 761659000724 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659000725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659000726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000727 PAS domain; Region: PAS_9; pfam13426 761659000728 putative active site [active] 761659000729 heme pocket [chemical binding]; other site 761659000730 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 761659000731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659000732 putative active site [active] 761659000733 heme pocket [chemical binding]; other site 761659000734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659000735 dimer interface [polypeptide binding]; other site 761659000736 phosphorylation site [posttranslational modification] 761659000737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659000738 ATP binding site [chemical binding]; other site 761659000739 Mg2+ binding site [ion binding]; other site 761659000740 G-X-G motif; other site 761659000741 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 761659000742 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 761659000743 Walker A/P-loop; other site 761659000744 ATP binding site [chemical binding]; other site 761659000745 Q-loop/lid; other site 761659000746 ABC transporter signature motif; other site 761659000747 Walker B; other site 761659000748 D-loop; other site 761659000749 H-loop/switch region; other site 761659000750 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 761659000751 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 761659000752 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 761659000753 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 761659000754 Zn binding site [ion binding]; other site 761659000755 Transposase; Region: DEDD_Tnp_IS110; pfam01548 761659000756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 761659000757 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 761659000758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 761659000759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 761659000760 HTH-like domain; Region: HTH_21; pfam13276 761659000761 Integrase core domain; Region: rve; pfam00665 761659000762 Integrase core domain; Region: rve_3; pfam13683 761659000763 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 761659000764 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 761659000765 active site 761659000766 metal-binding site [ion binding] 761659000767 nucleotide-binding site [chemical binding]; other site 761659000768 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 761659000769 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 761659000770 active site 761659000771 dimer interface [polypeptide binding]; other site 761659000772 Asparagine synthase; Region: Asn_synthase; pfam00733 761659000773 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 761659000774 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659000775 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 761659000776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659000777 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659000778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659000779 DDE superfamily endonuclease; Region: DDE_5; cl17874 761659000780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659000781 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 761659000782 Secretin and TonB N terminus short domain; Region: STN; smart00965 761659000783 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659000784 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659000785 FecR protein; Region: FecR; pfam04773 761659000786 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 761659000787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659000788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659000789 DNA binding residues [nucleotide binding] 761659000790 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 761659000791 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 761659000792 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 761659000793 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 761659000794 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 761659000795 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 761659000796 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 761659000797 PIN domain; Region: PIN_3; cl17397 761659000798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659000799 Probable transposase; Region: OrfB_IS605; pfam01385 761659000800 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659000801 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 761659000802 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 761659000803 active site 761659000804 NTP binding site [chemical binding]; other site 761659000805 metal binding triad [ion binding]; metal-binding site 761659000806 antibiotic binding site [chemical binding]; other site 761659000807 HEPN domain; Region: HEPN; cl00824 761659000808 RES domain; Region: RES; pfam08808 761659000809 RES domain; Region: RES; pfam08808 761659000810 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 761659000811 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 761659000812 Integrase core domain; Region: rve_3; cl15866 761659000813 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 761659000814 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 761659000815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659000816 Probable transposase; Region: OrfB_IS605; pfam01385 761659000817 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659000818 Chain length determinant protein; Region: Wzz; pfam02706 761659000819 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 761659000820 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 761659000821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659000822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659000823 NAD(P) binding site [chemical binding]; other site 761659000824 active site 761659000825 putative glycosyl transferase; Provisional; Region: PRK10307 761659000826 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 761659000827 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 761659000828 four helix bundle protein; Region: TIGR02436 761659000829 four helix bundle protein; Region: TIGR02436 761659000830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659000831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659000832 Walker A/P-loop; other site 761659000833 ATP binding site [chemical binding]; other site 761659000834 Q-loop/lid; other site 761659000835 ABC transporter signature motif; other site 761659000836 Walker B; other site 761659000837 D-loop; other site 761659000838 H-loop/switch region; other site 761659000839 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 761659000840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 761659000841 active site 761659000842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659000843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000844 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659000845 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 761659000846 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659000847 active site 761659000848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000849 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 761659000850 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 761659000851 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659000852 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659000853 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 761659000854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000855 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659000856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659000859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659000860 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 761659000861 putative ADP-binding pocket [chemical binding]; other site 761659000862 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 761659000863 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 761659000864 putative metal binding site; other site 761659000865 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 761659000866 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 761659000867 active site 761659000868 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 761659000869 dimer interface [polypeptide binding]; other site 761659000870 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 761659000871 Ligand Binding Site [chemical binding]; other site 761659000872 Molecular Tunnel; other site 761659000873 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 761659000874 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659000875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659000876 Walker A/P-loop; other site 761659000877 ATP binding site [chemical binding]; other site 761659000878 Q-loop/lid; other site 761659000879 ABC transporter signature motif; other site 761659000880 Walker B; other site 761659000881 D-loop; other site 761659000882 H-loop/switch region; other site 761659000883 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 761659000884 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 761659000885 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 761659000886 active site 761659000887 dimer interface [polypeptide binding]; other site 761659000888 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 761659000889 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 761659000890 Ligand Binding Site [chemical binding]; other site 761659000891 Molecular Tunnel; other site 761659000892 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 761659000893 active site 761659000894 metal-binding site [ion binding] 761659000895 nucleotide-binding site [chemical binding]; other site 761659000896 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 761659000897 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000898 putative pectinesterase; Region: PLN02432; cl01911 761659000899 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 761659000900 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659000901 FOG: PKD repeat [General function prediction only]; Region: COG3291 761659000902 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659000903 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 761659000904 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 761659000905 ligand binding site [chemical binding]; other site 761659000906 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 761659000907 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 761659000908 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 761659000909 putative active site [active] 761659000910 potential frameshift: common BLAST hit: gi|83815541|ref|YP_444988.1| ISSru4, transposase 761659000911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659000912 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 761659000913 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 761659000914 putative active site [active] 761659000915 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 761659000916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659000917 Probable transposase; Region: OrfB_IS605; pfam01385 761659000918 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659000919 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 761659000920 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 761659000921 ring oligomerisation interface [polypeptide binding]; other site 761659000922 ATP/Mg binding site [chemical binding]; other site 761659000923 stacking interactions; other site 761659000924 hinge regions; other site 761659000925 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 761659000926 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 761659000927 dimer interface [polypeptide binding]; other site 761659000928 active site 761659000929 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 761659000930 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659000931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659000932 active site 761659000933 phosphorylation site [posttranslational modification] 761659000934 intermolecular recognition site; other site 761659000935 dimerization interface [polypeptide binding]; other site 761659000936 LytTr DNA-binding domain; Region: LytTR; smart00850 761659000937 Histidine kinase; Region: His_kinase; pfam06580 761659000938 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 761659000939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659000940 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659000941 DNA-binding interface [nucleotide binding]; DNA binding site 761659000942 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 761659000943 Beta-lactamase; Region: Beta-lactamase; pfam00144 761659000944 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 761659000945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659000946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659000947 Amidohydrolase; Region: Amidohydro_4; pfam13147 761659000948 active site 761659000949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659000950 TPR motif; other site 761659000951 binding surface 761659000952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659000953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659000954 TPR motif; other site 761659000955 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 761659000956 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 761659000957 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 761659000958 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 761659000959 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 761659000960 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 761659000961 Ferredoxin [Energy production and conversion]; Region: COG1146 761659000962 4Fe-4S binding domain; Region: Fer4; pfam00037 761659000963 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 761659000964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659000965 dimerization interface [polypeptide binding]; other site 761659000966 putative DNA binding site [nucleotide binding]; other site 761659000967 Predicted transcriptional regulator [Transcription]; Region: COG2345 761659000968 putative Zn2+ binding site [ion binding]; other site 761659000969 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 761659000970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 761659000971 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 761659000972 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 761659000973 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659000974 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659000975 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659000976 starch binding outer membrane protein SusD; Region: SusD; cl17845 761659000977 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 761659000978 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659000979 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659000980 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659000981 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659000982 starch binding outer membrane protein SusD; Region: SusD; cd08977 761659000983 RES domain; Region: RES; pfam08808 761659000984 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659000985 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 761659000986 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 761659000987 Mg++ binding site [ion binding]; other site 761659000988 putative catalytic motif [active] 761659000989 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659000990 PEGA domain; Region: PEGA; pfam08308 761659000991 PEGA domain; Region: PEGA; pfam08308 761659000992 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 761659000993 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 761659000994 ssDNA binding site; other site 761659000995 generic binding surface II; other site 761659000996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659000997 ATP binding site [chemical binding]; other site 761659000998 putative Mg++ binding site [ion binding]; other site 761659000999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659001000 nucleotide binding region [chemical binding]; other site 761659001001 ATP-binding site [chemical binding]; other site 761659001002 Predicted membrane protein [Function unknown]; Region: COG2119 761659001003 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 761659001004 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 761659001005 active site 761659001006 metal binding site [ion binding]; metal-binding site 761659001007 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659001008 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 761659001009 putative active site [active] 761659001010 putative metal binding site [ion binding]; other site 761659001011 Methyltransferase domain; Region: Methyltransf_31; pfam13847 761659001012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659001013 S-adenosylmethionine binding site [chemical binding]; other site 761659001014 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 761659001015 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 761659001016 TPP-binding site [chemical binding]; other site 761659001017 dimer interface [polypeptide binding]; other site 761659001018 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 761659001019 PYR/PP interface [polypeptide binding]; other site 761659001020 dimer interface [polypeptide binding]; other site 761659001021 TPP binding site [chemical binding]; other site 761659001022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 761659001023 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 761659001024 active site 761659001025 intersubunit interactions; other site 761659001026 catalytic residue [active] 761659001027 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 761659001028 putative transporter; Provisional; Region: PRK10484 761659001029 Na binding site [ion binding]; other site 761659001030 substrate binding site [chemical binding]; other site 761659001031 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 761659001032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659001033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659001034 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 761659001035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659001036 active site 761659001037 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 761659001038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 761659001039 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659001040 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 761659001041 TM2 domain; Region: TM2; cl00984 761659001042 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 761659001043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 761659001044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 761659001045 catalytic residue [active] 761659001046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 761659001047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 761659001048 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 761659001049 Cation efflux family; Region: Cation_efflux; pfam01545 761659001050 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 761659001051 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 761659001052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659001053 Walker A/P-loop; other site 761659001054 ATP binding site [chemical binding]; other site 761659001055 Q-loop/lid; other site 761659001056 ABC transporter signature motif; other site 761659001057 Walker B; other site 761659001058 D-loop; other site 761659001059 H-loop/switch region; other site 761659001060 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659001061 C-terminal peptidase (prc); Region: prc; TIGR00225 761659001062 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659001063 Active site serine [active] 761659001064 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 761659001065 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659001066 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 761659001067 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 761659001068 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659001069 Active site serine [active] 761659001070 Penicillinase repressor; Region: Pencillinase_R; pfam03965 761659001071 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 761659001072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 761659001073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659001074 ATP binding site [chemical binding]; other site 761659001075 putative Mg++ binding site [ion binding]; other site 761659001076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659001077 nucleotide binding region [chemical binding]; other site 761659001078 ATP-binding site [chemical binding]; other site 761659001079 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 761659001080 HRDC domain; Region: HRDC; pfam00570 761659001081 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 761659001082 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 761659001083 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 761659001084 dimer interface [polypeptide binding]; other site 761659001085 active site 761659001086 effector binding site; other site 761659001087 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 761659001088 TSCPD domain; Region: TSCPD; cl14834 761659001089 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 761659001090 AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259 761659001091 putative catalytic residues [active] 761659001092 putative nucleotide binding site [chemical binding]; other site 761659001093 putative aspartate binding site [chemical binding]; other site 761659001094 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 761659001095 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 761659001096 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 761659001097 active site 761659001098 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 761659001099 substrate binding site [chemical binding]; other site 761659001100 catalytic residues [active] 761659001101 dimer interface [polypeptide binding]; other site 761659001102 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 761659001103 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 761659001104 Catalytic site [active] 761659001105 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 761659001106 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 761659001107 active site 761659001108 DNA binding site [nucleotide binding] 761659001109 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 761659001110 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 761659001111 Domain of unknown function (DUF814); Region: DUF814; pfam05670 761659001112 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 761659001113 PQQ-like domain; Region: PQQ_2; pfam13360 761659001114 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 761659001115 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659001116 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659001117 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 761659001118 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 761659001119 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 761659001120 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 761659001121 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659001122 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 761659001123 Walker A/P-loop; other site 761659001124 ATP binding site [chemical binding]; other site 761659001125 Q-loop/lid; other site 761659001126 ABC transporter signature motif; other site 761659001127 Walker B; other site 761659001128 D-loop; other site 761659001129 H-loop/switch region; other site 761659001130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 761659001131 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 761659001132 ligand binding site [chemical binding]; other site 761659001133 flexible hinge region; other site 761659001134 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 761659001135 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 761659001136 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 761659001137 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 761659001138 Putative D-pathway homolog; other site 761659001139 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 761659001140 Low-spin heme binding site [chemical binding]; other site 761659001141 Subunit I/II interface [polypeptide binding]; other site 761659001142 Putative Q-pathway; other site 761659001143 Putative alternate electron transfer pathway; other site 761659001144 Putative water exit pathway; other site 761659001145 Binuclear center (active site) [active] 761659001146 Putative K-pathway homolog; other site 761659001147 Putative proton exit pathway; other site 761659001148 Subunit I/IIa interface [polypeptide binding]; other site 761659001149 Electron transfer pathway; other site 761659001150 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 761659001151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 761659001152 DNA-binding site [nucleotide binding]; DNA binding site 761659001153 UTRA domain; Region: UTRA; pfam07702 761659001154 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 761659001155 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 761659001156 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 761659001157 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 761659001158 Low-spin heme binding site [chemical binding]; other site 761659001159 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 761659001160 D-pathway; other site 761659001161 Putative water exit pathway; other site 761659001162 Binuclear center (active site) [active] 761659001163 K-pathway; other site 761659001164 Putative proton exit pathway; other site 761659001165 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 761659001166 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 761659001167 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 761659001168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 761659001169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 761659001170 Soluble P-type ATPase [General function prediction only]; Region: COG4087 761659001171 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 761659001172 Rhodanese-like domain; Region: Rhodanese; pfam00581 761659001173 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 761659001174 active site residue [active] 761659001175 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 761659001176 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 761659001177 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 761659001178 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 761659001179 dimerization interface [polypeptide binding]; other site 761659001180 DPS ferroxidase diiron center [ion binding]; other site 761659001181 ion pore; other site 761659001182 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659001183 Protein export membrane protein; Region: SecD_SecF; cl14618 761659001184 DsrE/DsrF-like family; Region: DrsE; pfam02635 761659001185 Putative transcription activator [Transcription]; Region: TenA; COG0819 761659001186 GAF domain; Region: GAF; pfam01590 761659001187 PAS domain S-box; Region: sensory_box; TIGR00229 761659001188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001189 putative active site [active] 761659001190 heme pocket [chemical binding]; other site 761659001191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001192 putative active site [active] 761659001193 heme pocket [chemical binding]; other site 761659001194 PAS fold; Region: PAS; pfam00989 761659001195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001196 putative active site [active] 761659001197 heme pocket [chemical binding]; other site 761659001198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001199 PAS fold; Region: PAS_3; pfam08447 761659001200 putative active site [active] 761659001201 heme pocket [chemical binding]; other site 761659001202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659001203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001204 dimer interface [polypeptide binding]; other site 761659001205 phosphorylation site [posttranslational modification] 761659001206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001207 ATP binding site [chemical binding]; other site 761659001208 Mg2+ binding site [ion binding]; other site 761659001209 G-X-G motif; other site 761659001210 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 761659001211 active site 761659001212 metal binding site [ion binding]; metal-binding site 761659001213 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 761659001214 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 761659001215 metal-binding site [ion binding] 761659001216 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 761659001217 Soluble P-type ATPase [General function prediction only]; Region: COG4087 761659001218 CheB methylesterase; Region: CheB_methylest; pfam01339 761659001219 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 761659001220 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 761659001221 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 761659001222 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 761659001223 PAS domain; Region: PAS_10; pfam13596 761659001224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001225 putative active site [active] 761659001226 heme pocket [chemical binding]; other site 761659001227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001228 PAS domain; Region: PAS_9; pfam13426 761659001229 putative active site [active] 761659001230 heme pocket [chemical binding]; other site 761659001231 Histidine kinase; Region: HisKA_3; pfam07730 761659001232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001233 ATP binding site [chemical binding]; other site 761659001234 Mg2+ binding site [ion binding]; other site 761659001235 G-X-G motif; other site 761659001236 Bacitracin resistance protein BacA; Region: BacA; pfam02673 761659001237 EcsC protein family; Region: EcsC; pfam12787 761659001238 GTP-binding protein Der; Reviewed; Region: PRK00093 761659001239 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 761659001240 G1 box; other site 761659001241 GTP/Mg2+ binding site [chemical binding]; other site 761659001242 Switch I region; other site 761659001243 G2 box; other site 761659001244 Switch II region; other site 761659001245 G3 box; other site 761659001246 G4 box; other site 761659001247 G5 box; other site 761659001248 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 761659001249 G1 box; other site 761659001250 GTP/Mg2+ binding site [chemical binding]; other site 761659001251 Switch I region; other site 761659001252 G2 box; other site 761659001253 G3 box; other site 761659001254 Switch II region; other site 761659001255 G4 box; other site 761659001256 G5 box; other site 761659001257 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 761659001258 Protein of unknown function (DUF330); Region: DUF330; pfam03886 761659001259 mce related protein; Region: MCE; pfam02470 761659001260 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 761659001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659001262 Walker A/P-loop; other site 761659001263 ATP binding site [chemical binding]; other site 761659001264 Q-loop/lid; other site 761659001265 ABC transporter signature motif; other site 761659001266 Walker B; other site 761659001267 D-loop; other site 761659001268 H-loop/switch region; other site 761659001269 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 761659001270 Permease; Region: Permease; pfam02405 761659001271 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 761659001272 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 761659001273 ligand binding site [chemical binding]; other site 761659001274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 761659001275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 761659001276 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 761659001277 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 761659001278 active site 761659001279 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 761659001280 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 761659001281 active site 761659001282 Predicted transcriptional regulators [Transcription]; Region: COG1510 761659001283 MarR family; Region: MarR_2; pfam12802 761659001284 DNA helicase, putative; Region: TIGR00376 761659001285 AAA domain; Region: AAA_12; pfam13087 761659001286 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659001287 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 761659001288 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001290 GAF domain; Region: GAF; pfam01590 761659001291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001292 PAS domain; Region: PAS_9; pfam13426 761659001293 putative active site [active] 761659001294 heme pocket [chemical binding]; other site 761659001295 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659001296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001297 putative active site [active] 761659001298 heme pocket [chemical binding]; other site 761659001299 GAF domain; Region: GAF_3; pfam13492 761659001300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659001301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001302 dimer interface [polypeptide binding]; other site 761659001303 phosphorylation site [posttranslational modification] 761659001304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001305 ATP binding site [chemical binding]; other site 761659001306 Mg2+ binding site [ion binding]; other site 761659001307 G-X-G motif; other site 761659001308 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 761659001309 putative transporter; Provisional; Region: PRK10484 761659001310 Na binding site [ion binding]; other site 761659001311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 761659001312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 761659001313 DNA binding site [nucleotide binding] 761659001314 domain linker motif; other site 761659001315 Ligand-binding domain of uncharacterized transcription regulators from Thermus thermophilus and close homologs; Region: PBP1_LacI_like_12; cd06297 761659001316 putative dimerization interface [polypeptide binding]; other site 761659001317 putative ligand binding site [chemical binding]; other site 761659001318 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659001319 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659001320 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659001321 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 761659001322 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 761659001323 starch binding outer membrane protein SusD; Region: SusD; cd08977 761659001324 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 761659001325 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 761659001326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 761659001327 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659001328 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659001329 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659001330 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 761659001331 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001332 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 761659001333 starch binding outer membrane protein SusD; Region: SusD; cl17845 761659001334 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 761659001335 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 761659001336 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 761659001337 active site 761659001338 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 761659001339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 761659001340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 761659001341 DNA binding site [nucleotide binding] 761659001342 domain linker motif; other site 761659001343 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 761659001344 ligand binding site [chemical binding]; other site 761659001345 dimerization interface [polypeptide binding]; other site 761659001346 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 761659001347 putative ligand binding site [chemical binding]; other site 761659001348 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 761659001349 Na binding site [ion binding]; other site 761659001350 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 761659001351 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 761659001352 Beta-lactamase; Region: Beta-lactamase; pfam00144 761659001353 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 761659001354 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 761659001355 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 761659001356 Na binding site [ion binding]; other site 761659001357 FOG: CBS domain [General function prediction only]; Region: COG0517 761659001358 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 761659001359 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 761659001360 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 761659001361 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 761659001362 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 761659001363 substrate-cofactor binding pocket; other site 761659001364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659001365 catalytic residue [active] 761659001366 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659001368 NAD(P) binding site [chemical binding]; other site 761659001369 active site 761659001370 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 761659001371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659001372 dimerization interface [polypeptide binding]; other site 761659001373 putative DNA binding site [nucleotide binding]; other site 761659001374 putative Zn2+ binding site [ion binding]; other site 761659001375 AsnC family; Region: AsnC_trans_reg; pfam01037 761659001376 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 761659001377 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 761659001378 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 761659001379 adenylosuccinate lyase; Provisional; Region: PRK07492 761659001380 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 761659001381 tetramer interface [polypeptide binding]; other site 761659001382 active site 761659001383 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 761659001384 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 761659001385 Peroxin-3; Region: Peroxin-3; pfam04882 761659001386 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 761659001387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659001388 active site 761659001389 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659001390 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 761659001391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001392 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 761659001393 NADH dehydrogenase subunit B; Validated; Region: PRK06411 761659001394 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 761659001395 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 761659001396 NADH dehydrogenase subunit D; Validated; Region: PRK06075 761659001397 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 761659001398 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 761659001399 putative dimer interface [polypeptide binding]; other site 761659001400 [2Fe-2S] cluster binding site [ion binding]; other site 761659001401 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 761659001402 SLBB domain; Region: SLBB; pfam10531 761659001403 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 761659001404 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 761659001405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 761659001406 catalytic loop [active] 761659001407 iron binding site [ion binding]; other site 761659001408 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 761659001409 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 761659001410 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 761659001411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 761659001412 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 761659001413 Protein of unknown function (DUF421); Region: DUF421; pfam04239 761659001414 NAD synthetase; Provisional; Region: PRK13981 761659001415 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 761659001416 multimer interface [polypeptide binding]; other site 761659001417 active site 761659001418 catalytic triad [active] 761659001419 protein interface 1 [polypeptide binding]; other site 761659001420 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 761659001421 homodimer interface [polypeptide binding]; other site 761659001422 NAD binding pocket [chemical binding]; other site 761659001423 ATP binding pocket [chemical binding]; other site 761659001424 Mg binding site [ion binding]; other site 761659001425 active-site loop [active] 761659001426 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 761659001427 lipoprotein signal peptidase; Provisional; Region: PRK14787 761659001428 GTP-binding protein LepA; Provisional; Region: PRK05433 761659001429 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 761659001430 G1 box; other site 761659001431 putative GEF interaction site [polypeptide binding]; other site 761659001432 GTP/Mg2+ binding site [chemical binding]; other site 761659001433 Switch I region; other site 761659001434 G2 box; other site 761659001435 G3 box; other site 761659001436 Switch II region; other site 761659001437 G4 box; other site 761659001438 G5 box; other site 761659001439 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 761659001440 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 761659001441 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 761659001442 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 761659001443 Catalytic site [active] 761659001444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 761659001445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 761659001446 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 761659001447 Ion channel; Region: Ion_trans_2; pfam07885 761659001448 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659001449 TrkA-N domain; Region: TrkA_N; pfam02254 761659001450 TrkA-C domain; Region: TrkA_C; pfam02080 761659001451 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 761659001452 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 761659001453 nucleophile elbow; other site 761659001454 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 761659001455 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 761659001456 folate binding site [chemical binding]; other site 761659001457 NADP+ binding site [chemical binding]; other site 761659001458 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 761659001459 Amidase; Region: Amidase; cl11426 761659001460 Histidine kinase; Region: His_kinase; pfam06580 761659001461 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 761659001462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659001463 active site 761659001464 phosphorylation site [posttranslational modification] 761659001465 intermolecular recognition site; other site 761659001466 dimerization interface [polypeptide binding]; other site 761659001467 LytTr DNA-binding domain; Region: LytTR; smart00850 761659001468 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 761659001469 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659001470 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659001471 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 761659001472 thymidylate synthase; Reviewed; Region: thyA; PRK01827 761659001473 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 761659001474 dimerization interface [polypeptide binding]; other site 761659001475 active site 761659001476 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 761659001477 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 761659001478 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 761659001479 Active Sites [active] 761659001480 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 761659001481 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 761659001482 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 761659001483 dimer interface [polypeptide binding]; other site 761659001484 PYR/PP interface [polypeptide binding]; other site 761659001485 TPP binding site [chemical binding]; other site 761659001486 substrate binding site [chemical binding]; other site 761659001487 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 761659001488 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 761659001489 TPP-binding site [chemical binding]; other site 761659001490 Predicted membrane protein [Function unknown]; Region: COG2259 761659001491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659001492 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 761659001493 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 761659001494 intracellular protease, PfpI family; Region: PfpI; TIGR01382 761659001495 conserved cys residue [active] 761659001496 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 761659001497 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 761659001498 Walker A/P-loop; other site 761659001499 ATP binding site [chemical binding]; other site 761659001500 Q-loop/lid; other site 761659001501 ABC transporter signature motif; other site 761659001502 Walker B; other site 761659001503 D-loop; other site 761659001504 H-loop/switch region; other site 761659001505 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 761659001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659001507 dimer interface [polypeptide binding]; other site 761659001508 conserved gate region; other site 761659001509 putative PBP binding loops; other site 761659001510 ABC-ATPase subunit interface; other site 761659001511 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 761659001512 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 761659001513 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 761659001514 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 761659001515 Domain of unknown function (DUF389); Region: DUF389; cl00781 761659001516 Domain of unknown function (DUF389); Region: DUF389; pfam04087 761659001517 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 761659001518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659001519 putative substrate translocation pore; other site 761659001520 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659001521 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001522 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659001523 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 761659001524 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 761659001525 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659001526 putative catalytic site [active] 761659001527 putative metal binding site [ion binding]; other site 761659001528 putative phosphate binding site [ion binding]; other site 761659001529 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 761659001530 PhoU domain; Region: PhoU; pfam01895 761659001531 PhoU domain; Region: PhoU; pfam01895 761659001532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659001533 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 761659001534 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 761659001535 active site 761659001536 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 761659001537 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 761659001538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659001539 ABC transporter signature motif; other site 761659001540 Walker B; other site 761659001541 D-loop; other site 761659001542 H-loop/switch region; other site 761659001543 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 761659001544 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 761659001545 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 761659001546 Peptidase family M23; Region: Peptidase_M23; pfam01551 761659001547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 761659001548 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 761659001549 hypothetical protein; Provisional; Region: PRK07338 761659001550 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 761659001551 metal binding site [ion binding]; metal-binding site 761659001552 dimer interface [polypeptide binding]; other site 761659001553 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 761659001554 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 761659001555 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 761659001556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659001557 active site 761659001558 HIGH motif; other site 761659001559 nucleotide binding site [chemical binding]; other site 761659001560 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 761659001561 active site 761659001562 KMSKS motif; other site 761659001563 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 761659001564 tRNA binding surface [nucleotide binding]; other site 761659001565 anticodon binding site; other site 761659001566 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 761659001567 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 761659001568 RuvA N terminal domain; Region: RuvA_N; pfam01330 761659001569 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 761659001570 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 761659001571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659001572 active site 761659001573 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 761659001574 Protein of unknown function DUF72; Region: DUF72; pfam01904 761659001575 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 761659001576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659001577 Walker A motif; other site 761659001578 ATP binding site [chemical binding]; other site 761659001579 Walker B motif; other site 761659001580 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 761659001581 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 761659001582 G1 box; other site 761659001583 putative GEF interaction site [polypeptide binding]; other site 761659001584 GTP/Mg2+ binding site [chemical binding]; other site 761659001585 Switch I region; other site 761659001586 G2 box; other site 761659001587 G3 box; other site 761659001588 Switch II region; other site 761659001589 G4 box; other site 761659001590 G5 box; other site 761659001591 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 761659001592 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 761659001593 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 761659001594 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 761659001595 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 761659001596 HSP70 interaction site [polypeptide binding]; other site 761659001597 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 761659001598 substrate binding site [polypeptide binding]; other site 761659001599 dimer interface [polypeptide binding]; other site 761659001600 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 761659001601 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 761659001602 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 761659001603 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 761659001604 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 761659001605 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 761659001606 putative protofilament interface [polypeptide binding]; other site 761659001607 nucleotide binding site [chemical binding]; other site 761659001608 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659001609 GAF domain; Region: GAF; pfam01590 761659001610 PAS fold; Region: PAS_3; pfam08447 761659001611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001612 PAS fold; Region: PAS_3; pfam08447 761659001613 putative active site [active] 761659001614 heme pocket [chemical binding]; other site 761659001615 PAS domain S-box; Region: sensory_box; TIGR00229 761659001616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001617 putative active site [active] 761659001618 heme pocket [chemical binding]; other site 761659001619 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659001620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001621 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659001622 putative active site [active] 761659001623 heme pocket [chemical binding]; other site 761659001624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001625 putative active site [active] 761659001626 heme pocket [chemical binding]; other site 761659001627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001628 PAS domain; Region: PAS_9; pfam13426 761659001629 putative active site [active] 761659001630 heme pocket [chemical binding]; other site 761659001631 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659001632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001633 putative active site [active] 761659001634 heme pocket [chemical binding]; other site 761659001635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001636 PAS fold; Region: PAS_3; pfam08447 761659001637 putative active site [active] 761659001638 heme pocket [chemical binding]; other site 761659001639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659001640 GAF domain; Region: GAF_3; pfam13492 761659001641 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 761659001642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001643 dimer interface [polypeptide binding]; other site 761659001644 phosphorylation site [posttranslational modification] 761659001645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001646 ATP binding site [chemical binding]; other site 761659001647 Mg2+ binding site [ion binding]; other site 761659001648 G-X-G motif; other site 761659001649 PAS fold; Region: PAS_4; pfam08448 761659001650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001651 putative active site [active] 761659001652 PAS fold; Region: PAS_4; pfam08448 761659001653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001654 putative active site [active] 761659001655 heme pocket [chemical binding]; other site 761659001656 PAS domain S-box; Region: sensory_box; TIGR00229 761659001657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659001658 putative active site [active] 761659001659 heme pocket [chemical binding]; other site 761659001660 PAS fold; Region: PAS_4; pfam08448 761659001661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659001662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001663 dimer interface [polypeptide binding]; other site 761659001664 phosphorylation site [posttranslational modification] 761659001665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001666 ATP binding site [chemical binding]; other site 761659001667 Mg2+ binding site [ion binding]; other site 761659001668 G-X-G motif; other site 761659001669 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659001670 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 761659001671 four helix bundle protein; Region: TIGR02436 761659001672 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659001673 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659001674 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 761659001675 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 761659001676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659001677 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 761659001678 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 761659001679 active site 761659001680 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 761659001681 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 761659001682 homodimer interface [polypeptide binding]; other site 761659001683 substrate-cofactor binding pocket; other site 761659001684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659001685 catalytic residue [active] 761659001686 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 761659001687 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 761659001688 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 761659001689 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 761659001690 nucleotide binding site [chemical binding]; other site 761659001691 substrate binding site [chemical binding]; other site 761659001692 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 761659001693 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 761659001694 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 761659001695 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 761659001696 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 761659001697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001698 dimer interface [polypeptide binding]; other site 761659001699 phosphorylation site [posttranslational modification] 761659001700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001701 ATP binding site [chemical binding]; other site 761659001702 Mg2+ binding site [ion binding]; other site 761659001703 G-X-G motif; other site 761659001704 Response regulator receiver domain; Region: Response_reg; pfam00072 761659001705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659001706 active site 761659001707 phosphorylation site [posttranslational modification] 761659001708 intermolecular recognition site; other site 761659001709 Response regulator receiver domain; Region: Response_reg; pfam00072 761659001710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659001711 active site 761659001712 phosphorylation site [posttranslational modification] 761659001713 intermolecular recognition site; other site 761659001714 dimerization interface [polypeptide binding]; other site 761659001715 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 761659001716 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 761659001717 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 761659001718 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 761659001719 L-aspartate oxidase; Provisional; Region: PRK06175 761659001720 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 761659001721 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 761659001722 putative Iron-sulfur protein interface [polypeptide binding]; other site 761659001723 putative proximal heme binding site [chemical binding]; other site 761659001724 putative SdhC-like subunit interface [polypeptide binding]; other site 761659001725 putative distal heme binding site [chemical binding]; other site 761659001726 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 761659001727 putative Iron-sulfur protein interface [polypeptide binding]; other site 761659001728 putative proximal heme binding site [chemical binding]; other site 761659001729 putative SdhD-like interface [polypeptide binding]; other site 761659001730 putative distal heme binding site [chemical binding]; other site 761659001731 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 761659001732 dimer interface [polypeptide binding]; other site 761659001733 Citrate synthase; Region: Citrate_synt; pfam00285 761659001734 active site 761659001735 citrylCoA binding site [chemical binding]; other site 761659001736 oxalacetate/citrate binding site [chemical binding]; other site 761659001737 coenzyme A binding site [chemical binding]; other site 761659001738 catalytic triad [active] 761659001739 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 761659001740 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 761659001741 homodimer interface [polypeptide binding]; other site 761659001742 oligonucleotide binding site [chemical binding]; other site 761659001743 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 761659001744 putative hydrolase; Provisional; Region: PRK02113 761659001745 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659001746 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 761659001747 Dehydroquinase class II; Region: DHquinase_II; pfam01220 761659001748 active site 761659001749 trimer interface [polypeptide binding]; other site 761659001750 dimer interface [polypeptide binding]; other site 761659001751 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 761659001752 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 761659001753 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 761659001754 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 761659001755 4Fe-4S binding domain; Region: Fer4; pfam00037 761659001756 DinB superfamily; Region: DinB_2; pfam12867 761659001757 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 761659001758 DNA polymerase III, delta subunit; Region: holA; TIGR01128 761659001759 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 761659001760 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 761659001761 Low molecular weight phosphatase family; Region: LMWPc; cl00105 761659001762 active site 761659001763 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 761659001764 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 761659001765 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 761659001766 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 761659001767 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 761659001768 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 761659001769 NAD(P) binding site [chemical binding]; other site 761659001770 Bacterial Ig-like domain; Region: Big_5; pfam13205 761659001771 putative carbohydrate kinase; Provisional; Region: PRK10565 761659001772 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 761659001773 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 761659001774 putative substrate binding site [chemical binding]; other site 761659001775 putative ATP binding site [chemical binding]; other site 761659001776 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 761659001777 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659001778 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 761659001779 tetramer (dimer of dimers) interface [polypeptide binding]; other site 761659001780 active site 761659001781 dimer interface [polypeptide binding]; other site 761659001782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659001783 Coenzyme A binding pocket [chemical binding]; other site 761659001784 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 761659001785 Part of AAA domain; Region: AAA_19; pfam13245 761659001786 Family description; Region: UvrD_C_2; pfam13538 761659001787 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 761659001788 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 761659001789 P loop; other site 761659001790 Nucleotide binding site [chemical binding]; other site 761659001791 DTAP/Switch II; other site 761659001792 Switch I; other site 761659001793 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659001794 Magnesium ion binding site [ion binding]; other site 761659001795 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 761659001796 ParB-like nuclease domain; Region: ParBc; pfam02195 761659001797 KorB domain; Region: KorB; pfam08535 761659001798 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 761659001799 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 761659001800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659001801 catalytic residue [active] 761659001802 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 761659001803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659001804 active site 761659001805 motif I; other site 761659001806 motif II; other site 761659001807 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 761659001808 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 761659001809 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 761659001810 putative active site [active] 761659001811 catalytic triad [active] 761659001812 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 761659001813 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 761659001814 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 761659001815 active site 761659001816 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 761659001817 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 761659001818 dimer interface [polypeptide binding]; other site 761659001819 ssDNA binding site [nucleotide binding]; other site 761659001820 tetramer (dimer of dimers) interface [polypeptide binding]; other site 761659001821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659001822 Protein of unknown function (DUF328); Region: DUF328; pfam03883 761659001823 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 761659001824 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 761659001825 ATP-binding site [chemical binding]; other site 761659001826 Sugar specificity; other site 761659001827 Pyrimidine base specificity; other site 761659001828 Type III pantothenate kinase; Region: Pan_kinase; cl17198 761659001829 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 761659001830 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 761659001831 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 761659001832 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 761659001833 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 761659001834 active site 761659001835 dimerization interface [polypeptide binding]; other site 761659001836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659001837 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 761659001838 NAD(P) binding site [chemical binding]; other site 761659001839 active site 761659001840 phosphoglycolate phosphatase; Provisional; Region: PRK01158 761659001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659001842 Bacterial SH3 domain; Region: SH3_4; pfam06347 761659001843 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 761659001844 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659001845 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 761659001846 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 761659001847 Nucleoside recognition; Region: Gate; pfam07670 761659001848 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 761659001849 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 761659001850 Zn binding site [ion binding]; other site 761659001851 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 761659001852 Part of AAA domain; Region: AAA_19; pfam13245 761659001853 Family description; Region: UvrD_C_2; pfam13538 761659001854 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 761659001855 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 761659001856 Methyltransferase domain; Region: Methyltransf_12; pfam08242 761659001857 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 761659001858 nucleotide binding site/active site [active] 761659001859 HIT family signature motif; other site 761659001860 catalytic residue [active] 761659001861 Methyltransferase domain; Region: Methyltransf_31; pfam13847 761659001862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659001863 S-adenosylmethionine binding site [chemical binding]; other site 761659001864 HNH endonuclease; Region: HNH_4; pfam13395 761659001865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659001866 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 761659001867 Probable transposase; Region: OrfB_IS605; pfam01385 761659001868 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659001869 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 761659001870 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 761659001871 homodimer interface [polypeptide binding]; other site 761659001872 substrate-cofactor binding pocket; other site 761659001873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659001874 catalytic residue [active] 761659001875 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 761659001876 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 761659001877 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 761659001878 Protein of unknown function (DUF429); Region: DUF429; pfam04250 761659001879 Proline dehydrogenase; Region: Pro_dh; cl03282 761659001880 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 761659001881 putative ADP-ribose binding site [chemical binding]; other site 761659001882 putative active site [active] 761659001883 Methyltransferase domain; Region: Methyltransf_23; pfam13489 761659001884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659001885 S-adenosylmethionine binding site [chemical binding]; other site 761659001886 FOG: CBS domain [General function prediction only]; Region: COG0517 761659001887 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 761659001888 CTP synthetase; Validated; Region: pyrG; PRK05380 761659001889 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 761659001890 Catalytic site [active] 761659001891 active site 761659001892 UTP binding site [chemical binding]; other site 761659001893 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 761659001894 active site 761659001895 putative oxyanion hole; other site 761659001896 catalytic triad [active] 761659001897 LexA repressor; Validated; Region: PRK00215 761659001898 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 761659001899 cell division protein MraZ; Reviewed; Region: PRK00326 761659001900 MraZ protein; Region: MraZ; pfam02381 761659001901 MraZ protein; Region: MraZ; pfam02381 761659001902 MraW methylase family; Region: Methyltransf_5; cl17771 761659001903 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 761659001904 Septum formation initiator; Region: DivIC; cl17659 761659001905 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 761659001906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 761659001907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 761659001908 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 761659001909 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 761659001910 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 761659001911 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659001912 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 761659001913 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 761659001914 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 761659001915 Mg++ binding site [ion binding]; other site 761659001916 putative catalytic motif [active] 761659001917 putative substrate binding site [chemical binding]; other site 761659001918 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 761659001919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659001920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 761659001921 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 761659001922 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 761659001923 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 761659001924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659001925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 761659001926 Cell division protein FtsQ; Region: FtsQ; pfam03799 761659001927 cell division protein FtsA; Region: ftsA; TIGR01174 761659001928 Cell division protein FtsA; Region: FtsA; smart00842 761659001929 Cell division protein FtsA; Region: FtsA; pfam14450 761659001930 cell division protein FtsZ; Validated; Region: PRK09330 761659001931 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 761659001932 nucleotide binding site [chemical binding]; other site 761659001933 SulA interaction site; other site 761659001934 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 761659001935 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 761659001936 active site 761659001937 catalytic triad [active] 761659001938 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 761659001939 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659001940 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 761659001941 active site 761659001942 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 761659001943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659001944 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 761659001945 putative ADP-binding pocket [chemical binding]; other site 761659001946 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 761659001947 putative ADP-binding pocket [chemical binding]; other site 761659001948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 761659001949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 761659001950 active site 761659001951 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 761659001952 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 761659001953 Substrate binding site; other site 761659001954 Cupin domain; Region: Cupin_2; cl17218 761659001955 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 761659001956 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 761659001957 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 761659001958 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 761659001959 active site 761659001960 homotetramer interface [polypeptide binding]; other site 761659001961 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 761659001962 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 761659001963 active site 761659001964 catalytic site [active] 761659001965 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 761659001966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659001967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659001968 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 761659001969 alanine racemase; Reviewed; Region: alr; PRK00053 761659001970 active site 761659001971 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 761659001972 dimer interface [polypeptide binding]; other site 761659001973 substrate binding site [chemical binding]; other site 761659001974 catalytic residues [active] 761659001975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659001977 active site 761659001978 phosphorylation site [posttranslational modification] 761659001979 intermolecular recognition site; other site 761659001980 dimerization interface [polypeptide binding]; other site 761659001981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659001982 DNA binding site [nucleotide binding] 761659001983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659001984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659001985 dimerization interface [polypeptide binding]; other site 761659001986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659001987 dimer interface [polypeptide binding]; other site 761659001988 phosphorylation site [posttranslational modification] 761659001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659001990 ATP binding site [chemical binding]; other site 761659001991 Mg2+ binding site [ion binding]; other site 761659001992 G-X-G motif; other site 761659001993 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 761659001994 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 761659001995 tetramer interface [polypeptide binding]; other site 761659001996 TPP-binding site [chemical binding]; other site 761659001997 heterodimer interface [polypeptide binding]; other site 761659001998 phosphorylation loop region [posttranslational modification] 761659001999 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 761659002000 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 761659002001 alpha subunit interface [polypeptide binding]; other site 761659002002 TPP binding site [chemical binding]; other site 761659002003 heterodimer interface [polypeptide binding]; other site 761659002004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 761659002005 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 761659002006 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 761659002007 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 761659002008 Active Sites [active] 761659002009 Homeodomain-like domain; Region: HTH_23; pfam13384 761659002010 Winged helix-turn helix; Region: HTH_29; pfam13551 761659002011 Homeodomain-like domain; Region: HTH_32; pfam13565 761659002012 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659002013 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 761659002014 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 761659002015 CysD dimerization site [polypeptide binding]; other site 761659002016 G1 box; other site 761659002017 putative GEF interaction site [polypeptide binding]; other site 761659002018 GTP/Mg2+ binding site [chemical binding]; other site 761659002019 Switch I region; other site 761659002020 G2 box; other site 761659002021 G3 box; other site 761659002022 Switch II region; other site 761659002023 G4 box; other site 761659002024 G5 box; other site 761659002025 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 761659002026 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 761659002027 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 761659002028 ligand-binding site [chemical binding]; other site 761659002029 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 761659002030 active site 761659002031 NTP binding site [chemical binding]; other site 761659002032 metal binding triad [ion binding]; metal-binding site 761659002033 antibiotic binding site [chemical binding]; other site 761659002034 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 761659002035 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 761659002036 TrkA-C domain; Region: TrkA_C; pfam02080 761659002037 TrkA-C domain; Region: TrkA_C; pfam02080 761659002038 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 761659002039 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 761659002040 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 761659002041 active site 761659002042 NTP binding site [chemical binding]; other site 761659002043 metal binding triad [ion binding]; metal-binding site 761659002044 antibiotic binding site [chemical binding]; other site 761659002045 HEPN domain; Region: HEPN; pfam05168 761659002046 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 761659002047 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 761659002048 NAD binding site [chemical binding]; other site 761659002049 substrate binding site [chemical binding]; other site 761659002050 homodimer interface [polypeptide binding]; other site 761659002051 active site 761659002052 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 761659002053 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 761659002054 substrate binding site; other site 761659002055 tetramer interface; other site 761659002056 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 761659002057 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 761659002058 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 761659002059 NADP binding site [chemical binding]; other site 761659002060 active site 761659002061 putative substrate binding site [chemical binding]; other site 761659002062 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 761659002063 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 761659002064 SLBB domain; Region: SLBB; pfam10531 761659002065 SLBB domain; Region: SLBB; pfam10531 761659002066 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 761659002067 SLBB domain; Region: SLBB; pfam10531 761659002068 SLBB domain; Region: SLBB; pfam10531 761659002069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659002070 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659002071 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 761659002072 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659002073 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 761659002074 active site 761659002075 DNA binding site [nucleotide binding] 761659002076 Int/Topo IB signature motif; other site 761659002077 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 761659002078 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 761659002079 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 761659002080 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 761659002081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659002082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659002083 Walker A/P-loop; other site 761659002084 ATP binding site [chemical binding]; other site 761659002085 Q-loop/lid; other site 761659002086 ABC transporter signature motif; other site 761659002087 Walker B; other site 761659002088 D-loop; other site 761659002089 H-loop/switch region; other site 761659002090 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 761659002091 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 761659002092 NAD binding site [chemical binding]; other site 761659002093 substrate binding site [chemical binding]; other site 761659002094 active site 761659002095 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 761659002096 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 761659002097 inhibitor-cofactor binding pocket; inhibition site 761659002098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659002099 catalytic residue [active] 761659002100 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 761659002101 NeuB family; Region: NeuB; pfam03102 761659002102 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 761659002103 NeuB binding interface [polypeptide binding]; other site 761659002104 putative substrate binding site [chemical binding]; other site 761659002105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659002106 active site 761659002107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659002108 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 761659002109 NeuB family; Region: NeuB; pfam03102 761659002110 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 761659002111 NeuB binding interface [polypeptide binding]; other site 761659002112 putative substrate binding site [chemical binding]; other site 761659002113 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 761659002114 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 761659002115 putative trimer interface [polypeptide binding]; other site 761659002116 putative CoA binding site [chemical binding]; other site 761659002117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 761659002118 FOG: CBS domain [General function prediction only]; Region: COG0517 761659002119 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 761659002120 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 761659002121 Substrate binding site; other site 761659002122 metal-binding site 761659002123 potential frameshift: common BLAST hit: gi|118444511|ref|YP_877635.1| alginate O-acetylation protein 761659002124 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 761659002125 potential frameshift: common BLAST hit: gi|85858262|ref|YP_460464.1| membrane-bound O-acyltransferase 761659002126 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 761659002127 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 761659002128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 761659002129 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 761659002130 active site 761659002131 DDE superfamily endonuclease; Region: DDE_4; cl17710 761659002132 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659002133 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659002134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659002135 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659002136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659002137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002138 NAD(P) binding site [chemical binding]; other site 761659002139 active site 761659002140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002141 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659002142 NAD(P) binding site [chemical binding]; other site 761659002143 active site 761659002144 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 761659002145 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 761659002146 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 761659002147 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 761659002148 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 761659002149 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 761659002150 chromosome segregation protein; Provisional; Region: PRK03918 761659002151 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 761659002152 active site 761659002153 NTP binding site [chemical binding]; other site 761659002154 metal binding triad [ion binding]; metal-binding site 761659002155 antibiotic binding site [chemical binding]; other site 761659002156 Uncharacterized conserved protein [Function unknown]; Region: COG2361 761659002157 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 761659002158 putative active site [active] 761659002159 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 761659002160 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 761659002161 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 761659002162 putative active site [active] 761659002163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659002164 active site 761659002165 DNA binding site [nucleotide binding] 761659002166 Int/Topo IB signature motif; other site 761659002167 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 761659002168 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 761659002169 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 761659002170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659002171 putative DNA binding site [nucleotide binding]; other site 761659002172 putative Zn2+ binding site [ion binding]; other site 761659002173 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 761659002174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 761659002175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 761659002176 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 761659002177 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 761659002178 putative active site [active] 761659002179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 761659002180 non-specific DNA binding site [nucleotide binding]; other site 761659002181 salt bridge; other site 761659002182 sequence-specific DNA binding site [nucleotide binding]; other site 761659002183 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 761659002184 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 761659002185 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 761659002186 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 761659002187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659002188 Probable transposase; Region: OrfB_IS605; pfam01385 761659002189 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659002190 Transposase IS200 like; Region: Y1_Tnp; pfam01797 761659002191 Transposase; Region: DEDD_Tnp_IS110; pfam01548 761659002192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 761659002193 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 761659002194 PIN domain; Region: PIN_3; pfam13470 761659002195 Helix-turn-helix domain; Region: HTH_17; cl17695 761659002196 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659002197 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 761659002198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659002199 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659002200 DNA-binding interface [nucleotide binding]; DNA binding site 761659002201 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 761659002202 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 761659002203 Uncharacterized conserved protein [Function unknown]; Region: COG2442 761659002204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 761659002205 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 761659002206 PemK-like protein; Region: PemK; pfam02452 761659002207 HicB family; Region: HicB; pfam05534 761659002208 PIN domain; Region: PIN_3; pfam13470 761659002209 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 761659002210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659002211 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659002212 DNA-binding interface [nucleotide binding]; DNA binding site 761659002213 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 761659002214 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 761659002215 putative active site [active] 761659002216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659002217 active site 761659002218 DNA binding site [nucleotide binding] 761659002219 Int/Topo IB signature motif; other site 761659002220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659002221 Bacterial sugar transferase; Region: Bac_transf; pfam02397 761659002222 Probable transposase; Region: OrfB_IS605; pfam01385 761659002223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659002224 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659002225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002226 NAD(P) binding site [chemical binding]; other site 761659002227 active site 761659002228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659002229 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659002230 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659002231 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 761659002232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 761659002233 non-specific DNA binding site [nucleotide binding]; other site 761659002234 salt bridge; other site 761659002235 sequence-specific DNA binding site [nucleotide binding]; other site 761659002236 transcriptional activator RfaH; Region: RfaH; TIGR01955 761659002237 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886 761659002238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 761659002239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 761659002240 Transposase; Region: DEDD_Tnp_IS110; pfam01548 761659002241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659002242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002243 NAD(P) binding site [chemical binding]; other site 761659002244 active site 761659002245 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 761659002246 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 761659002247 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 761659002248 Protein of unknown function (DUF433); Region: DUF433; pfam04255 761659002249 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 761659002250 Transposase IS200 like; Region: Y1_Tnp; pfam01797 761659002251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659002252 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 761659002253 Probable transposase; Region: OrfB_IS605; pfam01385 761659002254 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659002255 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 761659002256 putative active site [active] 761659002257 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 761659002258 active site 761659002259 NTP binding site [chemical binding]; other site 761659002260 metal binding triad [ion binding]; metal-binding site 761659002261 antibiotic binding site [chemical binding]; other site 761659002262 Protein of unknown function DUF86; Region: DUF86; cl01031 761659002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002264 Protein of unknown function (DUF433); Region: DUF433; pfam04255 761659002265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 761659002266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002267 active site 761659002268 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 761659002269 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 761659002270 putative active site [active] 761659002271 Chorismate mutase type II; Region: CM_2; smart00830 761659002272 TPR repeat; Region: TPR_11; pfam13414 761659002273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002274 binding surface 761659002275 TPR motif; other site 761659002276 TPR repeat; Region: TPR_11; pfam13414 761659002277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002278 TPR motif; other site 761659002279 binding surface 761659002280 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 761659002281 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 761659002282 active site 761659002283 Substrate binding site; other site 761659002284 Mg++ binding site; other site 761659002285 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 761659002286 dimer interface [polypeptide binding]; other site 761659002287 N-terminal domain interface [polypeptide binding]; other site 761659002288 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 761659002289 MutS domain III; Region: MutS_III; pfam05192 761659002290 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 761659002291 Walker A/P-loop; other site 761659002292 ATP binding site [chemical binding]; other site 761659002293 Q-loop/lid; other site 761659002294 ABC transporter signature motif; other site 761659002295 Walker B; other site 761659002296 D-loop; other site 761659002297 H-loop/switch region; other site 761659002298 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 761659002299 Smr domain; Region: Smr; pfam01713 761659002300 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 761659002301 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 761659002302 dimerization interface [polypeptide binding]; other site 761659002303 ligand binding site [chemical binding]; other site 761659002304 NADP binding site [chemical binding]; other site 761659002305 catalytic site [active] 761659002306 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 761659002307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659002308 dimerization interface [polypeptide binding]; other site 761659002309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002310 dimer interface [polypeptide binding]; other site 761659002311 phosphorylation site [posttranslational modification] 761659002312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002313 ATP binding site [chemical binding]; other site 761659002314 Mg2+ binding site [ion binding]; other site 761659002315 G-X-G motif; other site 761659002316 Peptidase family M48; Region: Peptidase_M48; pfam01435 761659002317 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 761659002318 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 761659002319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659002320 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 761659002321 Probable transposase; Region: OrfB_IS605; pfam01385 761659002322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 761659002323 non-specific DNA binding site [nucleotide binding]; other site 761659002324 salt bridge; other site 761659002325 sequence-specific DNA binding site [nucleotide binding]; other site 761659002326 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 761659002327 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 761659002328 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 761659002329 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 761659002330 catalytic site [active] 761659002331 active site 761659002332 4-alpha-glucanotransferase; Provisional; Region: PRK14508 761659002333 Predicted membrane protein [Function unknown]; Region: COG3428 761659002334 Bacterial PH domain; Region: DUF304; pfam03703 761659002335 Bacterial PH domain; Region: DUF304; pfam03703 761659002336 Bacterial PH domain; Region: DUF304; pfam03703 761659002337 Uncharacterized conserved protein [Function unknown]; Region: COG3402 761659002338 shikimate kinase; Reviewed; Region: aroK; PRK00131 761659002339 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 761659002340 ADP binding site [chemical binding]; other site 761659002341 magnesium binding site [ion binding]; other site 761659002342 putative shikimate binding site; other site 761659002343 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 761659002344 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 761659002345 dimerization interface 3.5A [polypeptide binding]; other site 761659002346 active site 761659002347 Amidinotransferase; Region: Amidinotransf; cl12043 761659002348 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 761659002349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 761659002350 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 761659002351 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 761659002352 NAD binding site [chemical binding]; other site 761659002353 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 761659002354 CoA binding domain; Region: CoA_binding; smart00881 761659002355 CoA-ligase; Region: Ligase_CoA; pfam00549 761659002356 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 761659002357 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 761659002358 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 761659002359 adenosine deaminase; Provisional; Region: PRK09358 761659002360 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 761659002361 active site 761659002362 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 761659002363 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 761659002364 hinge; other site 761659002365 active site 761659002366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002367 Ligand Binding Site [chemical binding]; other site 761659002368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002369 Ligand Binding Site [chemical binding]; other site 761659002370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 761659002371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659002372 active site 761659002373 phosphorylation site [posttranslational modification] 761659002374 intermolecular recognition site; other site 761659002375 dimerization interface [polypeptide binding]; other site 761659002376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 761659002377 DNA binding residues [nucleotide binding] 761659002378 dimerization interface [polypeptide binding]; other site 761659002379 PAS domain S-box; Region: sensory_box; TIGR00229 761659002380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002381 putative active site [active] 761659002382 heme pocket [chemical binding]; other site 761659002383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 761659002384 Histidine kinase; Region: HisKA_3; pfam07730 761659002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002386 ATP binding site [chemical binding]; other site 761659002387 Mg2+ binding site [ion binding]; other site 761659002388 G-X-G motif; other site 761659002389 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 761659002390 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 761659002391 dimer interface [polypeptide binding]; other site 761659002392 NAD binding site [chemical binding]; other site 761659002393 substrate binding site [chemical binding]; other site 761659002394 tetramer (dimer of dimers) interface [polypeptide binding]; other site 761659002395 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 761659002396 GcpE protein; Region: GcpE; pfam04551 761659002397 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 761659002398 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 761659002399 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 761659002400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659002401 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 761659002402 putative active site [active] 761659002403 putative metal binding site [ion binding]; other site 761659002404 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 761659002405 Transglycosylase; Region: Transgly; pfam00912 761659002406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 761659002407 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 761659002408 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 761659002409 active site 761659002410 metal binding site [ion binding]; metal-binding site 761659002411 DNA binding site [nucleotide binding] 761659002412 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 761659002413 homoserine kinase; Provisional; Region: PRK01212 761659002414 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 761659002415 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 761659002416 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 761659002417 putative catalytic residues [active] 761659002418 putative nucleotide binding site [chemical binding]; other site 761659002419 putative aspartate binding site [chemical binding]; other site 761659002420 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 761659002421 dimer interface [polypeptide binding]; other site 761659002422 putative threonine allosteric regulatory site; other site 761659002423 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 761659002424 putative threonine allosteric regulatory site; other site 761659002425 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 761659002426 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 761659002427 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 761659002428 DivIVA protein; Region: DivIVA; pfam05103 761659002429 DivIVA domain; Region: DivI1A_domain; TIGR03544 761659002430 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 761659002431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 761659002432 catalytic residue [active] 761659002433 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 761659002434 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 761659002435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659002436 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 761659002437 Domain of unknown function (DUF427); Region: DUF427; pfam04248 761659002438 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 761659002439 NMT1/THI5 like; Region: NMT1; pfam09084 761659002440 FMN reductase; Validated; Region: fre; PRK08051 761659002441 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 761659002442 FAD binding pocket [chemical binding]; other site 761659002443 conserved FAD binding motif [chemical binding]; other site 761659002444 phosphate binding motif [ion binding]; other site 761659002445 beta-alpha-beta structure motif; other site 761659002446 NAD binding pocket [chemical binding]; other site 761659002447 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659002448 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659002449 TrkA-N domain; Region: TrkA_N; pfam02254 761659002450 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 761659002451 TIGR03643 family protein; Region: TIGR03643 761659002452 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 761659002453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 761659002454 catalytic Zn binding site [ion binding]; other site 761659002455 NAD(P) binding site [chemical binding]; other site 761659002456 structural Zn binding site [ion binding]; other site 761659002457 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 761659002458 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 761659002459 putative NAD(P) binding site [chemical binding]; other site 761659002460 catalytic Zn binding site [ion binding]; other site 761659002461 structural Zn binding site [ion binding]; other site 761659002462 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; pfam00338 761659002463 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 761659002464 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 761659002465 active site 761659002466 catalytic site [active] 761659002467 substrate binding site [chemical binding]; other site 761659002468 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 761659002469 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 761659002470 dimer interface [polypeptide binding]; other site 761659002471 ssDNA binding site [nucleotide binding]; other site 761659002472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 761659002473 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 761659002474 active sites [active] 761659002475 tetramer interface [polypeptide binding]; other site 761659002476 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 761659002477 Part of AAA domain; Region: AAA_19; pfam13245 761659002478 Family description; Region: UvrD_C_2; pfam13538 761659002479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659002480 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 761659002481 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 761659002482 active sites [active] 761659002483 tetramer interface [polypeptide binding]; other site 761659002484 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 761659002485 putative hydrophobic ligand binding site [chemical binding]; other site 761659002486 TIGR01777 family protein; Region: yfcH 761659002487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002488 NAD(P) binding site [chemical binding]; other site 761659002489 active site 761659002490 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659002491 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 761659002492 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 761659002493 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 761659002494 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 761659002495 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 761659002496 homodimer interface [polypeptide binding]; other site 761659002497 putative metal binding site [ion binding]; other site 761659002498 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 761659002499 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 761659002500 DsrE/DsrF-like family; Region: DrsE; pfam02635 761659002501 PEGA domain; Region: PEGA; pfam08308 761659002502 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 761659002503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 761659002504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659002505 NAD(P) binding site [chemical binding]; other site 761659002506 active site 761659002507 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 761659002508 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 761659002509 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 761659002510 generic binding surface II; other site 761659002511 generic binding surface I; other site 761659002512 Low molecular weight phosphatase family; Region: LMWPc; cd00115 761659002513 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 761659002514 active site 761659002515 Fructosamine kinase; Region: Fructosamin_kin; cl17579 761659002516 Phosphotransferase enzyme family; Region: APH; pfam01636 761659002517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 761659002518 catalytic loop [active] 761659002519 iron binding site [ion binding]; other site 761659002520 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 761659002521 phytoene desaturase; Region: crtI_fam; TIGR02734 761659002522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659002523 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 761659002524 Hemerythrin-like domain; Region: Hr-like; cd12108 761659002525 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 761659002526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659002527 FeS/SAM binding site; other site 761659002528 HemN C-terminal domain; Region: HemN_C; pfam06969 761659002529 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 761659002530 phosphate binding site [ion binding]; other site 761659002531 Rrf2 family protein; Region: rrf2_super; TIGR00738 761659002532 Transcriptional regulator; Region: Rrf2; pfam02082 761659002533 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659002534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659002535 active site 761659002536 phosphorylation site [posttranslational modification] 761659002537 intermolecular recognition site; other site 761659002538 dimerization interface [polypeptide binding]; other site 761659002539 LytTr DNA-binding domain; Region: LytTR; smart00850 761659002540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 761659002541 Histidine kinase; Region: His_kinase; pfam06580 761659002542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002543 ATP binding site [chemical binding]; other site 761659002544 Mg2+ binding site [ion binding]; other site 761659002545 G-X-G motif; other site 761659002546 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 761659002547 ABC-2 type transporter; Region: ABC2_membrane; cl17235 761659002548 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 761659002549 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 761659002550 Walker A/P-loop; other site 761659002551 ATP binding site [chemical binding]; other site 761659002552 Q-loop/lid; other site 761659002553 ABC transporter signature motif; other site 761659002554 Walker B; other site 761659002555 D-loop; other site 761659002556 H-loop/switch region; other site 761659002557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002558 TPR motif; other site 761659002559 binding surface 761659002560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659002562 TPR motif; other site 761659002563 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659002564 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659002565 biotin synthase; Validated; Region: PRK06256 761659002566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659002567 FeS/SAM binding site; other site 761659002568 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 761659002569 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659002570 GAF domain; Region: GAF_3; pfam13492 761659002571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659002572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002573 dimer interface [polypeptide binding]; other site 761659002574 phosphorylation site [posttranslational modification] 761659002575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002576 ATP binding site [chemical binding]; other site 761659002577 Mg2+ binding site [ion binding]; other site 761659002578 G-X-G motif; other site 761659002579 Homeodomain-like domain; Region: HTH_23; pfam13384 761659002580 Winged helix-turn helix; Region: HTH_29; pfam13551 761659002581 Homeodomain-like domain; Region: HTH_32; pfam13565 761659002582 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659002583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659002584 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 761659002585 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 761659002586 substrate binding site [chemical binding]; other site 761659002587 ATP binding site [chemical binding]; other site 761659002588 Dihydroneopterin aldolase; Region: FolB; pfam02152 761659002589 active site 761659002590 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 761659002591 catalytic triad [active] 761659002592 Maf-like protein; Region: Maf; pfam02545 761659002593 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 761659002594 active site 761659002595 dimer interface [polypeptide binding]; other site 761659002596 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 761659002597 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659002598 P-loop; other site 761659002599 Magnesium ion binding site [ion binding]; other site 761659002600 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659002601 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 761659002602 Na2 binding site [ion binding]; other site 761659002603 putative substrate binding site 1 [chemical binding]; other site 761659002604 Na binding site 1 [ion binding]; other site 761659002605 putative substrate binding site 2 [chemical binding]; other site 761659002606 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 761659002607 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 761659002608 metal binding site [ion binding]; metal-binding site 761659002609 dimer interface [polypeptide binding]; other site 761659002610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659002611 Serine hydrolase (FSH1); Region: FSH1; pfam03959 761659002612 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 761659002613 Uncharacterized conserved protein [Function unknown]; Region: COG2850 761659002614 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 761659002615 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 761659002616 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 761659002617 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 761659002618 dimer interface [polypeptide binding]; other site 761659002619 active site 761659002620 glycine-pyridoxal phosphate binding site [chemical binding]; other site 761659002621 folate binding site [chemical binding]; other site 761659002622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659002623 active site 761659002624 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 761659002625 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659002626 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 761659002627 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 761659002628 protein binding site [polypeptide binding]; other site 761659002629 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 761659002630 Catalytic dyad [active] 761659002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659002632 S-adenosylmethionine binding site [chemical binding]; other site 761659002633 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 761659002634 nudix motif; other site 761659002635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002636 Ligand Binding Site [chemical binding]; other site 761659002637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002638 Ligand Binding Site [chemical binding]; other site 761659002639 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 761659002640 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 761659002641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 761659002642 nucleotide binding site [chemical binding]; other site 761659002643 Septum formation initiator; Region: DivIC; pfam04977 761659002644 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 761659002645 enolase; Provisional; Region: eno; PRK00077 761659002646 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 761659002647 dimer interface [polypeptide binding]; other site 761659002648 metal binding site [ion binding]; metal-binding site 761659002649 substrate binding pocket [chemical binding]; other site 761659002650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002651 binding surface 761659002652 TPR motif; other site 761659002653 TPR repeat; Region: TPR_11; pfam13414 761659002654 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 761659002655 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 761659002656 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 761659002657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659002658 Walker A/P-loop; other site 761659002659 ATP binding site [chemical binding]; other site 761659002660 Q-loop/lid; other site 761659002661 ABC transporter signature motif; other site 761659002662 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 761659002663 lipoyl synthase; Provisional; Region: PRK05481 761659002664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659002665 FeS/SAM binding site; other site 761659002666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 761659002667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 761659002668 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 761659002669 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 761659002670 active site 761659002671 L-lysine aminotransferase; Provisional; Region: PRK08297 761659002672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 761659002673 inhibitor-cofactor binding pocket; inhibition site 761659002674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659002675 catalytic residue [active] 761659002676 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 761659002677 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 761659002678 Walker A/P-loop; other site 761659002679 ATP binding site [chemical binding]; other site 761659002680 Q-loop/lid; other site 761659002681 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 761659002682 ABC transporter signature motif; other site 761659002683 Walker B; other site 761659002684 D-loop; other site 761659002685 H-loop/switch region; other site 761659002686 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 761659002687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 761659002688 ATP binding site [chemical binding]; other site 761659002689 putative Mg++ binding site [ion binding]; other site 761659002690 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 761659002691 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 761659002692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659002693 nucleotide binding region [chemical binding]; other site 761659002694 ATP-binding site [chemical binding]; other site 761659002695 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002696 Ligand Binding Site [chemical binding]; other site 761659002697 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659002698 Ligand Binding Site [chemical binding]; other site 761659002699 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 761659002700 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659002701 active site 761659002702 DNA binding site [nucleotide binding] 761659002703 Int/Topo IB signature motif; other site 761659002704 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 761659002705 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 761659002706 oligomer interface [polypeptide binding]; other site 761659002707 metal binding site [ion binding]; metal-binding site 761659002708 metal binding site [ion binding]; metal-binding site 761659002709 Cl binding site [ion binding]; other site 761659002710 aspartate ring; other site 761659002711 basic sphincter; other site 761659002712 putative hydrophobic gate; other site 761659002713 periplasmic entrance; other site 761659002714 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 761659002715 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 761659002716 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 761659002717 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659002718 Protein of unknown function (DUF432); Region: DUF432; cl01027 761659002719 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 761659002720 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 761659002721 transmembrane helices; other site 761659002722 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 761659002723 TrkA-C domain; Region: TrkA_C; pfam02080 761659002724 TrkA-C domain; Region: TrkA_C; pfam02080 761659002725 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 761659002726 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 761659002727 E3 interaction surface; other site 761659002728 lipoyl attachment site [posttranslational modification]; other site 761659002729 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 761659002730 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 761659002731 E3 interaction surface; other site 761659002732 lipoyl attachment site [posttranslational modification]; other site 761659002733 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 761659002734 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 761659002735 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 761659002736 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 761659002737 putative active site [active] 761659002738 catalytic residue [active] 761659002739 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 761659002740 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 761659002741 5S rRNA interface [nucleotide binding]; other site 761659002742 CTC domain interface [polypeptide binding]; other site 761659002743 L16 interface [polypeptide binding]; other site 761659002744 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 761659002745 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 761659002746 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659002747 active site 761659002748 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 761659002749 nudix motif; other site 761659002750 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 761659002751 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 761659002752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002753 TPR motif; other site 761659002754 binding surface 761659002755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002756 binding surface 761659002757 TPR motif; other site 761659002758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659002759 binding surface 761659002760 TPR motif; other site 761659002761 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 761659002762 antiporter inner membrane protein; Provisional; Region: PRK11670 761659002763 Domain of unknown function DUF59; Region: DUF59; pfam01883 761659002764 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 761659002765 Walker A motif; other site 761659002766 exopolyphosphatase; Region: exo_poly_only; TIGR03706 761659002767 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 761659002768 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 761659002769 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 761659002770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 761659002771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659002772 S-adenosylmethionine binding site [chemical binding]; other site 761659002773 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 761659002774 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 761659002775 6-phosphofructokinase; Provisional; Region: PRK03202 761659002776 active site 761659002777 ADP/pyrophosphate binding site [chemical binding]; other site 761659002778 dimerization interface [polypeptide binding]; other site 761659002779 allosteric effector site; other site 761659002780 fructose-1,6-bisphosphate binding site; other site 761659002781 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 761659002782 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 761659002783 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 761659002784 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 761659002785 carboxyltransferase (CT) interaction site; other site 761659002786 biotinylation site [posttranslational modification]; other site 761659002787 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 761659002788 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 761659002789 putative NADP binding site [chemical binding]; other site 761659002790 putative substrate binding site [chemical binding]; other site 761659002791 active site 761659002792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659002793 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 761659002794 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 761659002795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659002796 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659002797 PAS domain S-box; Region: sensory_box; TIGR00229 761659002798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002799 putative active site [active] 761659002800 heme pocket [chemical binding]; other site 761659002801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002802 PAS domain; Region: PAS_9; pfam13426 761659002803 putative active site [active] 761659002804 heme pocket [chemical binding]; other site 761659002805 PAS domain; Region: PAS_9; pfam13426 761659002806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002807 dimer interface [polypeptide binding]; other site 761659002808 phosphorylation site [posttranslational modification] 761659002809 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 761659002810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002811 ATP binding site [chemical binding]; other site 761659002812 Mg2+ binding site [ion binding]; other site 761659002813 G-X-G motif; other site 761659002814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002815 PAS domain; Region: PAS_9; pfam13426 761659002816 putative active site [active] 761659002817 heme pocket [chemical binding]; other site 761659002818 PAS fold; Region: PAS_4; pfam08448 761659002819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002820 putative active site [active] 761659002821 heme pocket [chemical binding]; other site 761659002822 PAS domain S-box; Region: sensory_box; TIGR00229 761659002823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659002824 putative active site [active] 761659002825 heme pocket [chemical binding]; other site 761659002826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659002827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002828 dimer interface [polypeptide binding]; other site 761659002829 phosphorylation site [posttranslational modification] 761659002830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002831 ATP binding site [chemical binding]; other site 761659002832 Mg2+ binding site [ion binding]; other site 761659002833 G-X-G motif; other site 761659002834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002836 ATP binding site [chemical binding]; other site 761659002837 Mg2+ binding site [ion binding]; other site 761659002838 G-X-G motif; other site 761659002839 Response regulator receiver domain; Region: Response_reg; pfam00072 761659002840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659002841 active site 761659002842 phosphorylation site [posttranslational modification] 761659002843 intermolecular recognition site; other site 761659002844 dimerization interface [polypeptide binding]; other site 761659002845 HDOD domain; Region: HDOD; pfam08668 761659002846 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659002847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659002848 catalytic residue [active] 761659002849 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 761659002850 active site 761659002851 phosphorylation site [posttranslational modification] 761659002852 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 761659002853 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 761659002854 dimer interface [polypeptide binding]; other site 761659002855 motif 1; other site 761659002856 active site 761659002857 motif 2; other site 761659002858 motif 3; other site 761659002859 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 761659002860 anticodon binding site; other site 761659002861 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 761659002862 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659002863 putative catalytic site [active] 761659002864 putative phosphate binding site [ion binding]; other site 761659002865 putative metal binding site [ion binding]; other site 761659002866 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 761659002867 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 761659002868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659002869 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659002870 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 761659002871 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659002872 N-terminal plug; other site 761659002873 ligand-binding site [chemical binding]; other site 761659002874 glycogen branching enzyme; Provisional; Region: PRK12313 761659002875 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 761659002876 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 761659002877 active site 761659002878 catalytic site [active] 761659002879 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 761659002880 trehalose synthase; Region: treS_nterm; TIGR02456 761659002881 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 761659002882 active site 761659002883 catalytic site [active] 761659002884 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 761659002885 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 761659002886 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 761659002887 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 761659002888 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 761659002889 active site 761659002890 homodimer interface [polypeptide binding]; other site 761659002891 catalytic site [active] 761659002892 acceptor binding site [chemical binding]; other site 761659002893 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 761659002894 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 761659002895 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 761659002896 active site 761659002897 catalytic site [active] 761659002898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 761659002899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 761659002900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 761659002901 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659002902 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 761659002903 putative active site [active] 761659002904 Zn binding site [ion binding]; other site 761659002905 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659002906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659002907 active site 761659002908 phosphorylation site [posttranslational modification] 761659002909 intermolecular recognition site; other site 761659002910 dimerization interface [polypeptide binding]; other site 761659002911 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659002912 TrkA-N domain; Region: TrkA_N; pfam02254 761659002913 TrkA-C domain; Region: TrkA_C; pfam02080 761659002914 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 761659002915 DNA polymerase III subunit delta'; Validated; Region: PRK05564 761659002916 DNA polymerase III subunit delta'; Validated; Region: PRK08485 761659002917 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 761659002918 metal ion-dependent adhesion site (MIDAS); other site 761659002919 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 761659002920 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 761659002921 active site 761659002922 ATP binding site [chemical binding]; other site 761659002923 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 761659002924 oligomerisation interface [polypeptide binding]; other site 761659002925 mobile loop; other site 761659002926 roof hairpin; other site 761659002927 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 761659002928 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 761659002929 putative active site [active] 761659002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002931 dimer interface [polypeptide binding]; other site 761659002932 phosphorylation site [posttranslational modification] 761659002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002934 ATP binding site [chemical binding]; other site 761659002935 Mg2+ binding site [ion binding]; other site 761659002936 G-X-G motif; other site 761659002937 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 761659002938 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 761659002939 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 761659002940 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 761659002941 intersubunit interface [polypeptide binding]; other site 761659002942 Uncharacterized conserved protein [Function unknown]; Region: COG3391 761659002943 Uncharacterized conserved protein [Function unknown]; Region: COG3391 761659002944 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 761659002945 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659002946 N-terminal plug; other site 761659002947 ligand-binding site [chemical binding]; other site 761659002948 Phage shock protein B; Region: PspB; cl05946 761659002949 phosphonate C-P lyase system protein PhnK; Region: CP_lyasePhnK; TIGR02323 761659002950 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 761659002951 PAS domain; Region: PAS; smart00091 761659002952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659002953 dimer interface [polypeptide binding]; other site 761659002954 phosphorylation site [posttranslational modification] 761659002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659002956 ATP binding site [chemical binding]; other site 761659002957 Mg2+ binding site [ion binding]; other site 761659002958 G-X-G motif; other site 761659002959 haloalkane dehalogenase; Provisional; Region: PRK03204 761659002960 HTH domain; Region: HTH_11; pfam08279 761659002961 Predicted transcriptional regulator [Transcription]; Region: COG2378 761659002962 WYL domain; Region: WYL; pfam13280 761659002963 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 761659002964 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 761659002965 ligand binding site [chemical binding]; other site 761659002966 active site 761659002967 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 761659002968 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 761659002969 short chain dehydrogenase; Provisional; Region: PRK07326 761659002970 classical (c) SDRs; Region: SDR_c; cd05233 761659002971 NAD(P) binding site [chemical binding]; other site 761659002972 active site 761659002973 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 761659002974 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 761659002975 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 761659002976 NusB family; Region: NusB; pfam01029 761659002977 putative RNA binding site [nucleotide binding]; other site 761659002978 16S rRNA methyltransferase B; Provisional; Region: PRK14902 761659002979 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 761659002980 Predicted membrane protein [Function unknown]; Region: COG2323 761659002981 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 761659002982 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659002983 active site 761659002984 DNA binding site [nucleotide binding] 761659002985 Int/Topo IB signature motif; other site 761659002986 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 761659002987 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 761659002988 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 761659002989 nucleotide binding pocket [chemical binding]; other site 761659002990 K-X-D-G motif; other site 761659002991 catalytic site [active] 761659002992 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 761659002993 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 761659002994 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 761659002995 Dimer interface [polypeptide binding]; other site 761659002996 BRCT sequence motif; other site 761659002997 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659002998 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 761659002999 AAA domain; Region: AAA_23; pfam13476 761659003000 Walker A/P-loop; other site 761659003001 ATP binding site [chemical binding]; other site 761659003002 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 761659003003 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 761659003004 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 761659003005 ABC transporter signature motif; other site 761659003006 Walker B; other site 761659003007 D-loop; other site 761659003008 H-loop/switch region; other site 761659003009 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659003010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 761659003011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659003012 dimerization interface [polypeptide binding]; other site 761659003013 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 761659003014 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 761659003015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659003016 PBP superfamily domain; Region: PBP_like_2; cl17296 761659003017 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 761659003018 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 761659003019 Beta-lactamase; Region: Beta-lactamase; pfam00144 761659003020 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 761659003021 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 761659003022 amidophosphoribosyltransferase; Provisional; Region: PRK09123 761659003023 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 761659003024 active site 761659003025 tetramer interface [polypeptide binding]; other site 761659003026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659003027 active site 761659003028 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 761659003029 Na2 binding site [ion binding]; other site 761659003030 putative substrate binding site 1 [chemical binding]; other site 761659003031 Na binding site 1 [ion binding]; other site 761659003032 putative substrate binding site 2 [chemical binding]; other site 761659003033 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 761659003034 Na2 binding site [ion binding]; other site 761659003035 putative substrate binding site 1 [chemical binding]; other site 761659003036 Na binding site 1 [ion binding]; other site 761659003037 putative substrate binding site 2 [chemical binding]; other site 761659003038 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 761659003039 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 761659003040 hexamer interface [polypeptide binding]; other site 761659003041 ligand binding site [chemical binding]; other site 761659003042 putative active site [active] 761659003043 NAD(P) binding site [chemical binding]; other site 761659003044 Rossmann-like domain; Region: Rossmann-like; pfam10727 761659003045 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 761659003046 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 761659003047 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 761659003048 dimer interface [polypeptide binding]; other site 761659003049 putative anticodon binding site; other site 761659003050 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 761659003051 motif 1; other site 761659003052 active site 761659003053 motif 2; other site 761659003054 motif 3; other site 761659003055 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659003056 PKD domain; Region: PKD; pfam00801 761659003057 OmpA family; Region: OmpA; pfam00691 761659003058 ligand binding site [chemical binding]; other site 761659003059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 761659003060 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 761659003061 Peptidase family M23; Region: Peptidase_M23; pfam01551 761659003062 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 761659003063 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 761659003064 ATP synthase A chain; Region: ATP-synt_A; cl00413 761659003065 ATP synthase subunit C; Region: ATP-synt_C; cl00466 761659003066 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 761659003067 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 761659003068 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 761659003069 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 761659003070 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 761659003071 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 761659003072 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 761659003073 beta subunit interaction interface [polypeptide binding]; other site 761659003074 Walker A motif; other site 761659003075 ATP binding site [chemical binding]; other site 761659003076 Walker B motif; other site 761659003077 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 761659003078 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 761659003079 core domain interface [polypeptide binding]; other site 761659003080 delta subunit interface [polypeptide binding]; other site 761659003081 epsilon subunit interface [polypeptide binding]; other site 761659003082 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 761659003083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659003084 NAD(P) binding site [chemical binding]; other site 761659003085 active site 761659003086 AAA domain; Region: AAA_30; pfam13604 761659003087 AAA domain; Region: AAA_22; pfam13401 761659003088 Family description; Region: UvrD_C_2; pfam13538 761659003089 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 761659003090 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 761659003091 active site 761659003092 dimer interface [polypeptide binding]; other site 761659003093 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 761659003094 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 761659003095 intersubunit interface [polypeptide binding]; other site 761659003096 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 761659003097 substrate binding site [chemical binding]; other site 761659003098 THF binding site; other site 761659003099 zinc-binding site [ion binding]; other site 761659003100 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 761659003101 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 761659003102 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659003103 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 761659003104 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 761659003105 Domain of unknown function DUF21; Region: DUF21; pfam01595 761659003106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 761659003107 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659003108 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659003109 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659003110 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659003111 Outer membrane efflux protein; Region: OEP; pfam02321 761659003112 Outer membrane efflux protein; Region: OEP; pfam02321 761659003113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659003114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659003115 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 761659003116 ABC1 family; Region: ABC1; cl17513 761659003117 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 761659003118 active site 761659003119 ATP binding site [chemical binding]; other site 761659003120 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 761659003121 active site residue [active] 761659003122 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 761659003123 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 761659003124 active site residue [active] 761659003125 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 761659003126 active site residue [active] 761659003127 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 761659003128 aminoacyl-tRNA ligase; Region: PLN02563 761659003129 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 761659003130 HIGH motif; other site 761659003131 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 761659003132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659003133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659003134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659003135 active site 761659003136 KMSKS motif; other site 761659003137 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 761659003138 tRNA binding surface [nucleotide binding]; other site 761659003139 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 761659003140 translation elongation factor P; Region: efp; TIGR00038 761659003141 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 761659003142 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 761659003143 RNA binding site [nucleotide binding]; other site 761659003144 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 761659003145 RNA binding site [nucleotide binding]; other site 761659003146 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 761659003147 carboxyltransferase (CT) interaction site; other site 761659003148 biotinylation site [posttranslational modification]; other site 761659003149 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 761659003150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 761659003151 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 761659003152 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 761659003153 aspartate aminotransferase; Provisional; Region: PRK05764 761659003154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 761659003155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659003156 homodimer interface [polypeptide binding]; other site 761659003157 catalytic residue [active] 761659003158 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 761659003159 Peptidase family M50; Region: Peptidase_M50; pfam02163 761659003160 active site 761659003161 putative substrate binding region [chemical binding]; other site 761659003162 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 761659003163 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659003164 CAAX protease self-immunity; Region: Abi; pfam02517 761659003165 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 761659003166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659003167 acyl-CoA esterase; Provisional; Region: PRK10673 761659003168 PGAP1-like protein; Region: PGAP1; pfam07819 761659003169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 761659003170 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 761659003171 putative NAD(P) binding site [chemical binding]; other site 761659003172 putative active site [active] 761659003173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 761659003174 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659003175 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 761659003176 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 761659003177 active site 761659003178 catalytic site [active] 761659003179 substrate binding site [chemical binding]; other site 761659003180 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 761659003181 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659003182 P-loop; other site 761659003183 Magnesium ion binding site [ion binding]; other site 761659003184 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659003185 Magnesium ion binding site [ion binding]; other site 761659003186 putative catalytic site [active] 761659003187 putative metal binding site [ion binding]; other site 761659003188 putative phosphate binding site [ion binding]; other site 761659003189 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659003190 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 761659003191 catalytic center binding site [active] 761659003192 ATP binding site [chemical binding]; other site 761659003193 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 761659003194 Substrate-binding site [chemical binding]; other site 761659003195 Substrate specificity [chemical binding]; other site 761659003196 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659003197 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 761659003198 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 761659003199 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 761659003200 catalytic site [active] 761659003201 subunit interface [polypeptide binding]; other site 761659003202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 761659003203 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 761659003204 ATP-grasp domain; Region: ATP-grasp_4; cl17255 761659003205 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 761659003206 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 761659003207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 761659003208 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 761659003209 ATP-grasp domain; Region: ATP-grasp_4; cl17255 761659003210 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 761659003211 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 761659003212 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 761659003213 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 761659003214 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 761659003215 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 761659003216 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 761659003217 DNA-binding site [nucleotide binding]; DNA binding site 761659003218 RNA-binding motif; other site 761659003219 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 761659003220 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 761659003221 trimer interface [polypeptide binding]; other site 761659003222 active site 761659003223 substrate binding site [chemical binding]; other site 761659003224 CoA binding site [chemical binding]; other site 761659003225 DNA primase; Validated; Region: dnaG; PRK05667 761659003226 CHC2 zinc finger; Region: zf-CHC2; pfam01807 761659003227 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 761659003228 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 761659003229 active site 761659003230 metal binding site [ion binding]; metal-binding site 761659003231 interdomain interaction site; other site 761659003232 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 761659003233 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 761659003234 Peptidase C26; Region: Peptidase_C26; pfam07722 761659003235 catalytic triad [active] 761659003236 Smr domain; Region: Smr; pfam01713 761659003237 SWIM zinc finger; Region: SWIM; pfam04434 761659003238 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 761659003239 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 761659003240 catalytic triad [active] 761659003241 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659003242 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 761659003243 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 761659003244 active site 761659003245 PHP Thumb interface [polypeptide binding]; other site 761659003246 metal binding site [ion binding]; metal-binding site 761659003247 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 761659003248 generic binding surface II; other site 761659003249 generic binding surface I; other site 761659003250 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 761659003251 D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810 761659003252 putative N- and C-terminal domain interface [polypeptide binding]; other site 761659003253 putative active site [active] 761659003254 putative MgATP binding site [chemical binding]; other site 761659003255 catalytic site [active] 761659003256 metal binding site [ion binding]; metal-binding site 761659003257 putative xylulose binding site [chemical binding]; other site 761659003258 putative homodimer interface [polypeptide binding]; other site 761659003259 Protein of unknown function (DUF819); Region: DUF819; cl02317 761659003260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 761659003261 binding surface 761659003262 TPR motif; other site 761659003263 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 761659003264 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352 761659003265 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 761659003266 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 761659003267 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659003268 active site 761659003269 HIGH motif; other site 761659003270 nucleotide binding site [chemical binding]; other site 761659003271 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 761659003272 KMSK motif region; other site 761659003273 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 761659003274 tRNA binding surface [nucleotide binding]; other site 761659003275 anticodon binding site; other site 761659003276 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 761659003277 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 761659003278 Catalytic site [active] 761659003279 Cupin domain; Region: Cupin_2; pfam07883 761659003280 recombination factor protein RarA; Reviewed; Region: PRK13342 761659003281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659003282 Walker A motif; other site 761659003283 ATP binding site [chemical binding]; other site 761659003284 Walker B motif; other site 761659003285 arginine finger; other site 761659003286 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 761659003287 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 761659003288 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 761659003289 active site residue [active] 761659003290 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 761659003291 active site residue [active] 761659003292 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 761659003293 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 761659003294 DctM-like transporters; Region: DctM; pfam06808 761659003295 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 761659003296 NADH(P)-binding; Region: NAD_binding_10; pfam13460 761659003297 NAD(P) binding site [chemical binding]; other site 761659003298 putative active site [active] 761659003299 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659003300 Methyltransferase domain; Region: Methyltransf_23; pfam13489 761659003301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659003302 S-adenosylmethionine binding site [chemical binding]; other site 761659003303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 761659003304 Predicted integral membrane protein [Function unknown]; Region: COG5617 761659003305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 761659003306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659003307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659003308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 761659003309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659003310 Walker A/P-loop; other site 761659003311 ATP binding site [chemical binding]; other site 761659003312 Q-loop/lid; other site 761659003313 ABC transporter signature motif; other site 761659003314 Walker B; other site 761659003315 D-loop; other site 761659003316 H-loop/switch region; other site 761659003317 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659003318 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 761659003319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659003320 active site 761659003321 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 761659003322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659003323 putative ADP-binding pocket [chemical binding]; other site 761659003324 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 761659003325 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659003326 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 761659003327 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 761659003328 DHH family; Region: DHH; pfam01368 761659003329 DHHA1 domain; Region: DHHA1; pfam02272 761659003330 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 761659003331 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 761659003332 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 761659003333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659003334 Walker A/P-loop; other site 761659003335 ATP binding site [chemical binding]; other site 761659003336 Q-loop/lid; other site 761659003337 ABC transporter signature motif; other site 761659003338 Walker B; other site 761659003339 D-loop; other site 761659003340 H-loop/switch region; other site 761659003341 Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494 761659003342 active site 761659003343 catalytic triad [active] 761659003344 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 761659003345 minor groove reading motif; other site 761659003346 helix-hairpin-helix signature motif; other site 761659003347 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 761659003348 dimer interface [polypeptide binding]; other site 761659003349 active site 761659003350 aspartate-rich active site metal binding site; other site 761659003351 allosteric magnesium binding site [ion binding]; other site 761659003352 Schiff base residues; other site 761659003353 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 761659003354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659003355 active site 761659003356 HIGH motif; other site 761659003357 nucleotide binding site [chemical binding]; other site 761659003358 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 761659003359 KMSKS motif; other site 761659003360 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 761659003361 Transcriptional regulators [Transcription]; Region: MarR; COG1846 761659003362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659003363 putative DNA binding site [nucleotide binding]; other site 761659003364 dimerization interface [polypeptide binding]; other site 761659003365 putative Zn2+ binding site [ion binding]; other site 761659003366 Haemolytic domain; Region: Haemolytic; pfam01809 761659003367 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 761659003368 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 761659003369 Na binding site [ion binding]; other site 761659003370 Methyltransferase domain; Region: Methyltransf_31; pfam13847 761659003371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659003372 S-adenosylmethionine binding site [chemical binding]; other site 761659003373 Spore germination protein; Region: Spore_permease; cl17796 761659003374 Amino acid permease; Region: AA_permease_2; pfam13520 761659003375 TspO/MBR family; Region: TspO_MBR; pfam03073 761659003376 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 761659003377 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 761659003378 putative NAD(P) binding site [chemical binding]; other site 761659003379 putative active site [active] 761659003380 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 761659003381 hydrophobic ligand binding site; other site 761659003382 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 761659003383 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 761659003384 Peptidase family M50; Region: Peptidase_M50; pfam02163 761659003385 active site 761659003386 putative substrate binding region [chemical binding]; other site 761659003387 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 761659003388 FOG: CBS domain [General function prediction only]; Region: COG0517 761659003389 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 761659003390 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 761659003391 domain interfaces; other site 761659003392 active site 761659003393 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 761659003394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659003395 binding surface 761659003396 TPR motif; other site 761659003397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659003398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659003399 binding surface 761659003400 TPR motif; other site 761659003401 FtsH Extracellular; Region: FtsH_ext; pfam06480 761659003402 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 761659003403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659003404 Walker A motif; other site 761659003405 ATP binding site [chemical binding]; other site 761659003406 Walker B motif; other site 761659003407 arginine finger; other site 761659003408 Peptidase family M41; Region: Peptidase_M41; pfam01434 761659003409 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 761659003410 S17 interaction site [polypeptide binding]; other site 761659003411 S8 interaction site; other site 761659003412 16S rRNA interaction site [nucleotide binding]; other site 761659003413 streptomycin interaction site [chemical binding]; other site 761659003414 23S rRNA interaction site [nucleotide binding]; other site 761659003415 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 761659003416 30S ribosomal protein S7; Validated; Region: PRK05302 761659003417 elongation factor G; Reviewed; Region: PRK00007 761659003418 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 761659003419 G1 box; other site 761659003420 putative GEF interaction site [polypeptide binding]; other site 761659003421 GTP/Mg2+ binding site [chemical binding]; other site 761659003422 Switch I region; other site 761659003423 G2 box; other site 761659003424 G3 box; other site 761659003425 Switch II region; other site 761659003426 G4 box; other site 761659003427 G5 box; other site 761659003428 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 761659003429 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 761659003430 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 761659003431 elongation factor Tu; Reviewed; Region: PRK00049 761659003432 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 761659003433 G1 box; other site 761659003434 GEF interaction site [polypeptide binding]; other site 761659003435 GTP/Mg2+ binding site [chemical binding]; other site 761659003436 Switch I region; other site 761659003437 G2 box; other site 761659003438 G3 box; other site 761659003439 Switch II region; other site 761659003440 G4 box; other site 761659003441 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 761659003442 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 761659003443 Antibiotic Binding Site [chemical binding]; other site 761659003444 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 761659003445 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 761659003446 50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953 761659003447 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 761659003448 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 761659003449 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 761659003450 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 761659003451 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 761659003452 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 761659003453 protein-rRNA interface [nucleotide binding]; other site 761659003454 putative translocon binding site; other site 761659003455 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 761659003456 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 761659003457 G-X-X-G motif; other site 761659003458 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 761659003459 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 761659003460 23S rRNA interface [nucleotide binding]; other site 761659003461 5S rRNA interface [nucleotide binding]; other site 761659003462 putative antibiotic binding site [chemical binding]; other site 761659003463 L25 interface [polypeptide binding]; other site 761659003464 L27 interface [polypeptide binding]; other site 761659003465 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 761659003466 putative translocon interaction site; other site 761659003467 23S rRNA interface [nucleotide binding]; other site 761659003468 signal recognition particle (SRP54) interaction site; other site 761659003469 L23 interface [polypeptide binding]; other site 761659003470 trigger factor interaction site; other site 761659003471 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 761659003472 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 761659003473 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 761659003474 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 761659003475 RNA binding site [nucleotide binding]; other site 761659003476 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 761659003477 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 761659003478 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 761659003479 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 761659003480 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 761659003481 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 761659003482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 761659003483 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 761659003484 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 761659003485 5S rRNA interface [nucleotide binding]; other site 761659003486 L27 interface [polypeptide binding]; other site 761659003487 23S rRNA interface [nucleotide binding]; other site 761659003488 L5 interface [polypeptide binding]; other site 761659003489 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 761659003490 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 761659003491 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 761659003492 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 761659003493 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 761659003494 SecY translocase; Region: SecY; pfam00344 761659003495 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 761659003496 active site 761659003497 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 761659003498 rRNA binding site [nucleotide binding]; other site 761659003499 predicted 30S ribosome binding site; other site 761659003500 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 761659003501 30S ribosomal protein S13; Region: bact_S13; TIGR03631 761659003502 30S ribosomal protein S11; Validated; Region: PRK05309 761659003503 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 761659003504 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 761659003505 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 761659003506 RNA binding surface [nucleotide binding]; other site 761659003507 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 761659003508 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 761659003509 alphaNTD homodimer interface [polypeptide binding]; other site 761659003510 alphaNTD - beta interaction site [polypeptide binding]; other site 761659003511 alphaNTD - beta' interaction site [polypeptide binding]; other site 761659003512 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 761659003513 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 761659003514 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 761659003515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 761659003516 Zn2+ binding site [ion binding]; other site 761659003517 Mg2+ binding site [ion binding]; other site 761659003518 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 761659003519 synthetase active site [active] 761659003520 NTP binding site [chemical binding]; other site 761659003521 metal binding site [ion binding]; metal-binding site 761659003522 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 761659003523 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 761659003524 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 761659003525 IHF - DNA interface [nucleotide binding]; other site 761659003526 IHF dimer interface [polypeptide binding]; other site 761659003527 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 761659003528 Protein of unknown function DUF72; Region: DUF72; cl00777 761659003529 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 761659003530 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 761659003531 active site 761659003532 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 761659003533 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 761659003534 homopentamer interface [polypeptide binding]; other site 761659003535 active site 761659003536 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 761659003537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659003538 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 761659003539 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 761659003540 methionine sulfoxide reductase A; Provisional; Region: PRK14054 761659003541 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 761659003542 active site 761659003543 multimer interface [polypeptide binding]; other site 761659003544 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 761659003545 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 761659003546 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 761659003547 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 761659003548 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 761659003549 dimer interface [polypeptide binding]; other site 761659003550 active site 761659003551 catalytic residue [active] 761659003552 dihydrodipicolinate reductase; Provisional; Region: PRK00048 761659003553 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 761659003554 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 761659003555 DNA photolyase; Region: DNA_photolyase; pfam00875 761659003556 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 761659003557 Double zinc ribbon; Region: DZR; pfam12773 761659003558 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 761659003559 Cupin domain; Region: Cupin_2; cl17218 761659003560 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 761659003561 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 761659003562 homodimer interface [polypeptide binding]; other site 761659003563 metal binding site [ion binding]; metal-binding site 761659003564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 761659003565 homodimer interface [polypeptide binding]; other site 761659003566 active site 761659003567 putative chemical substrate binding site [chemical binding]; other site 761659003568 metal binding site [ion binding]; metal-binding site 761659003569 HAS barrel domain; Region: HAS-barrel; pfam09378 761659003570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 761659003571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 761659003572 active site 761659003573 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 761659003574 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 761659003575 dimerization interface [polypeptide binding]; other site 761659003576 DPS ferroxidase diiron center [ion binding]; other site 761659003577 ion pore; other site 761659003578 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 761659003579 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 761659003580 active site 761659003581 interdomain interaction site; other site 761659003582 putative metal-binding site [ion binding]; other site 761659003583 nucleotide binding site [chemical binding]; other site 761659003584 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 761659003585 domain I; other site 761659003586 phosphate binding site [ion binding]; other site 761659003587 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 761659003588 domain II; other site 761659003589 domain III; other site 761659003590 nucleotide binding site [chemical binding]; other site 761659003591 DNA binding groove [nucleotide binding] 761659003592 catalytic site [active] 761659003593 domain IV; other site 761659003594 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 761659003595 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 761659003596 GTPase RsgA; Reviewed; Region: PRK00098 761659003597 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 761659003598 RNA binding site [nucleotide binding]; other site 761659003599 homodimer interface [polypeptide binding]; other site 761659003600 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 761659003601 GTPase/Zn-binding domain interface [polypeptide binding]; other site 761659003602 GTP/Mg2+ binding site [chemical binding]; other site 761659003603 G4 box; other site 761659003604 G5 box; other site 761659003605 G1 box; other site 761659003606 Switch I region; other site 761659003607 G2 box; other site 761659003608 G3 box; other site 761659003609 Switch II region; other site 761659003610 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 761659003611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659003612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659003613 dimer interface [polypeptide binding]; other site 761659003614 phosphorylation site [posttranslational modification] 761659003615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659003616 ATP binding site [chemical binding]; other site 761659003617 Mg2+ binding site [ion binding]; other site 761659003618 G-X-G motif; other site 761659003619 Response regulator receiver domain; Region: Response_reg; pfam00072 761659003620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659003621 active site 761659003622 phosphorylation site [posttranslational modification] 761659003623 intermolecular recognition site; other site 761659003624 dimerization interface [polypeptide binding]; other site 761659003625 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 761659003626 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 761659003627 dimer interface [polypeptide binding]; other site 761659003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659003629 catalytic residue [active] 761659003630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 761659003631 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 761659003632 Predicted permeases [General function prediction only]; Region: COG0795 761659003633 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 761659003634 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 761659003635 CoA-ligase; Region: Ligase_CoA; pfam00549 761659003636 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 761659003637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659003638 active site 761659003639 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 761659003640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659003641 active site 761659003642 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 761659003643 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 761659003644 Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the...; Region: Mth938; cd05126 761659003645 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 761659003646 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 761659003647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659003648 FeS/SAM binding site; other site 761659003649 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 761659003650 Protein of unknown function (DUF433); Region: DUF433; pfam04255 761659003651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 761659003652 ATP-grasp domain; Region: ATP-grasp_4; cl17255 761659003653 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 761659003654 phosphoenolpyruvate synthase; Validated; Region: PRK06464 761659003655 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 761659003656 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 761659003657 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 761659003658 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 761659003659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 761659003660 Probable transposase; Region: OrfB_IS605; pfam01385 761659003661 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 761659003662 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 761659003663 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 761659003664 homotetramer interface [polypeptide binding]; other site 761659003665 ligand binding site [chemical binding]; other site 761659003666 catalytic site [active] 761659003667 NAD binding site [chemical binding]; other site 761659003668 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 761659003669 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 761659003670 Predicted archaeal kinase (sugar kinase superfamily) [General function prediction only]; Region: COG1829 761659003671 Penicillin amidase; Region: Penicil_amidase; pfam01804 761659003672 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 761659003673 active site 761659003674 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 761659003675 Predicted membrane protein [Function unknown]; Region: COG2259 761659003676 Ferredoxin [Energy production and conversion]; Region: COG1146 761659003677 4Fe-4S binding domain; Region: Fer4; cl02805 761659003678 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 761659003679 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 761659003680 protein-splicing catalytic site; other site 761659003681 thioester formation/cholesterol transfer; other site 761659003682 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 761659003683 thioester formation/cholesterol transfer; other site 761659003684 protein-splicing catalytic site; other site 761659003685 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 761659003686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659003687 Walker B motif; other site 761659003688 arginine finger; other site 761659003689 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 761659003690 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 761659003691 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 761659003692 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 761659003693 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 761659003694 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659003695 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659003696 catalytic residue [active] 761659003697 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 761659003698 elongation factor G; Reviewed; Region: PRK12740 761659003699 G1 box; other site 761659003700 putative GEF interaction site [polypeptide binding]; other site 761659003701 GTP/Mg2+ binding site [chemical binding]; other site 761659003702 Switch I region; other site 761659003703 G2 box; other site 761659003704 G3 box; other site 761659003705 Switch II region; other site 761659003706 G4 box; other site 761659003707 G5 box; other site 761659003708 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 761659003709 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 761659003710 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 761659003711 Predicted metal-binding protein [General function prediction only]; Region: COG3019 761659003712 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 761659003713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 761659003714 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 761659003715 putative NAD(P) binding site [chemical binding]; other site 761659003716 active site 761659003717 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 761659003718 Glycoprotease family; Region: Peptidase_M22; pfam00814 761659003719 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 761659003720 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 761659003721 FG-GAP repeat; Region: FG-GAP_2; pfam14312 761659003722 FG-GAP repeat; Region: FG-GAP_2; pfam14312 761659003723 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 761659003724 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 761659003725 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 761659003726 Family description; Region: VCBS; pfam13517 761659003727 excinuclease ABC subunit B; Provisional; Region: PRK05298 761659003728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659003729 ATP binding site [chemical binding]; other site 761659003730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659003731 nucleotide binding region [chemical binding]; other site 761659003732 ATP-binding site [chemical binding]; other site 761659003733 Ultra-violet resistance protein B; Region: UvrB; pfam12344 761659003734 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 761659003735 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 761659003736 homodimer interface [polypeptide binding]; other site 761659003737 substrate-cofactor binding pocket; other site 761659003738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659003739 catalytic residue [active] 761659003740 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 761659003741 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 761659003742 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 761659003743 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 761659003744 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 761659003745 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 761659003746 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 761659003747 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 761659003748 trimer interface [polypeptide binding]; other site 761659003749 dimer interface [polypeptide binding]; other site 761659003750 putative active site [active] 761659003751 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 761659003752 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 761659003753 active site 761659003754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659003755 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 761659003756 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 761659003757 active site 761659003758 dimer interface [polypeptide binding]; other site 761659003759 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 761659003760 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 761659003761 active site 761659003762 FMN binding site [chemical binding]; other site 761659003763 substrate binding site [chemical binding]; other site 761659003764 3Fe-4S cluster binding site [ion binding]; other site 761659003765 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 761659003766 domain interface; other site 761659003767 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 761659003768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659003769 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 761659003770 putative active site [active] 761659003771 dimerization interface [polypeptide binding]; other site 761659003772 putative tRNAtyr binding site [nucleotide binding]; other site 761659003773 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 761659003774 active site 761659003775 dimerization interface [polypeptide binding]; other site 761659003776 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 761659003777 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 761659003778 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 761659003779 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 761659003780 TPP-binding site [chemical binding]; other site 761659003781 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 761659003782 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659003783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659003784 NAD(P) binding site [chemical binding]; other site 761659003785 active site 761659003786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659003787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659003788 active site 761659003789 phosphorylation site [posttranslational modification] 761659003790 intermolecular recognition site; other site 761659003791 dimerization interface [polypeptide binding]; other site 761659003792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659003793 DNA binding site [nucleotide binding] 761659003794 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 761659003795 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 761659003796 Recombination protein O N terminal; Region: RecO_N; pfam11967 761659003797 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 761659003798 Recombination protein O C terminal; Region: RecO_C; pfam02565 761659003799 LexA repressor; Validated; Region: PRK00215 761659003800 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 761659003801 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 761659003802 Catalytic site [active] 761659003803 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 761659003804 DNA photolyase; Region: DNA_photolyase; pfam00875 761659003805 Methyltransferase domain; Region: Methyltransf_31; pfam13847 761659003806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659003807 S-adenosylmethionine binding site [chemical binding]; other site 761659003808 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659003809 Protein export membrane protein; Region: SecD_SecF; cl14618 761659003810 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659003811 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659003812 Uncharacterized conserved protein [Function unknown]; Region: COG1739 761659003813 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 761659003814 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 761659003815 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 761659003816 RNA/DNA hybrid binding site [nucleotide binding]; other site 761659003817 active site 761659003818 GTPase CgtA; Reviewed; Region: obgE; PRK12299 761659003819 GTP1/OBG; Region: GTP1_OBG; pfam01018 761659003820 Obg GTPase; Region: Obg; cd01898 761659003821 G1 box; other site 761659003822 GTP/Mg2+ binding site [chemical binding]; other site 761659003823 Switch I region; other site 761659003824 G2 box; other site 761659003825 G3 box; other site 761659003826 Switch II region; other site 761659003827 G4 box; other site 761659003828 G5 box; other site 761659003829 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 761659003830 DNA protecting protein DprA; Region: dprA; TIGR00732 761659003831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 761659003832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659003833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659003834 catalytic residue [active] 761659003835 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 761659003836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 761659003837 RNA binding surface [nucleotide binding]; other site 761659003838 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 761659003839 active site 761659003840 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 761659003841 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 761659003842 active site 761659003843 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659003844 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 761659003845 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 761659003846 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 761659003847 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659003848 Penicillinase repressor; Region: Pencillinase_R; pfam03965 761659003849 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 761659003850 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 761659003851 Probable Catalytic site; other site 761659003852 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 761659003853 Amidinotransferase; Region: Amidinotransf; cl12043 761659003854 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 761659003855 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 761659003856 Walker A/P-loop; other site 761659003857 ATP binding site [chemical binding]; other site 761659003858 Q-loop/lid; other site 761659003859 ABC transporter signature motif; other site 761659003860 Walker B; other site 761659003861 D-loop; other site 761659003862 H-loop/switch region; other site 761659003863 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 761659003864 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659003865 Phosphoglycerate kinase; Region: PGK; pfam00162 761659003866 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 761659003867 substrate binding site [chemical binding]; other site 761659003868 hinge regions; other site 761659003869 ADP binding site [chemical binding]; other site 761659003870 catalytic site [active] 761659003871 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 761659003872 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 761659003873 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 761659003874 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 761659003875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659003876 active site 761659003877 phosphorylation site [posttranslational modification] 761659003878 intermolecular recognition site; other site 761659003879 dimerization interface [polypeptide binding]; other site 761659003880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659003881 Walker A motif; other site 761659003882 ATP binding site [chemical binding]; other site 761659003883 Walker B motif; other site 761659003884 arginine finger; other site 761659003885 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659003886 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659003887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 761659003888 Walker A/P-loop; other site 761659003889 ATP binding site [chemical binding]; other site 761659003890 Q-loop/lid; other site 761659003891 ABC transporter signature motif; other site 761659003892 Walker B; other site 761659003893 D-loop; other site 761659003894 H-loop/switch region; other site 761659003895 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 761659003896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 761659003897 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 761659003898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659003899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659003900 WHG domain; Region: WHG; pfam13305 761659003901 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 761659003902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 761659003903 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 761659003904 acyl-activating enzyme (AAE) consensus motif; other site 761659003905 acyl-activating enzyme (AAE) consensus motif; other site 761659003906 putative AMP binding site [chemical binding]; other site 761659003907 putative active site [active] 761659003908 putative CoA binding site [chemical binding]; other site 761659003909 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 761659003910 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 761659003911 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 761659003912 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 761659003913 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 761659003914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 761659003915 substrate binding site [chemical binding]; other site 761659003916 oxyanion hole (OAH) forming residues; other site 761659003917 trimer interface [polypeptide binding]; other site 761659003918 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 761659003919 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 761659003920 dimer interface [polypeptide binding]; other site 761659003921 active site 761659003922 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 761659003923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659003924 NAD(P) binding site [chemical binding]; other site 761659003925 active site 761659003926 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 761659003927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 761659003928 active site 761659003929 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 761659003930 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 761659003931 short chain dehydrogenase; Provisional; Region: PRK07677 761659003932 NAD(P) binding site [chemical binding]; other site 761659003933 substrate binding site [chemical binding]; other site 761659003934 homotetramer interface [polypeptide binding]; other site 761659003935 active site 761659003936 homodimer interface [polypeptide binding]; other site 761659003937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659003938 protoporphyrinogen oxidase; Region: PLN02576 761659003939 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 761659003940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659003941 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659003942 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 761659003943 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 761659003944 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 761659003945 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 761659003946 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 761659003947 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 761659003948 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 761659003949 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 761659003950 substrate binding pocket [chemical binding]; other site 761659003951 chain length determination region; other site 761659003952 substrate-Mg2+ binding site; other site 761659003953 catalytic residues [active] 761659003954 aspartate-rich region 1; other site 761659003955 active site lid residues [active] 761659003956 aspartate-rich region 2; other site 761659003957 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 761659003958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 761659003959 ABC-ATPase subunit interface; other site 761659003960 dimer interface [polypeptide binding]; other site 761659003961 putative PBP binding regions; other site 761659003962 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 761659003963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659003964 active site 761659003965 phosphorylation site [posttranslational modification] 761659003966 intermolecular recognition site; other site 761659003967 dimerization interface [polypeptide binding]; other site 761659003968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659003969 Walker A motif; other site 761659003970 ATP binding site [chemical binding]; other site 761659003971 Walker B motif; other site 761659003972 arginine finger; other site 761659003973 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 761659003974 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 761659003975 intersubunit interface [polypeptide binding]; other site 761659003976 active site 761659003977 catalytic residue [active] 761659003978 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 761659003979 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 761659003980 NAD(P) binding site [chemical binding]; other site 761659003981 catalytic residues [active] 761659003982 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 761659003983 NAD(P) binding site [chemical binding]; other site 761659003984 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659003985 Sporulation related domain; Region: SPOR; pfam05036 761659003986 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659003987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659003988 catalytic residue [active] 761659003989 FAD dependent oxidoreductase; Region: DAO; pfam01266 761659003990 hydroxyglutarate oxidase; Provisional; Region: PRK11728 761659003991 hydroxyglutarate oxidase; Provisional; Region: PRK11728 761659003992 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 761659003993 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 761659003994 thiS-thiF/thiG interaction site; other site 761659003995 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 761659003996 ThiS interaction site; other site 761659003997 putative active site [active] 761659003998 tetramer interface [polypeptide binding]; other site 761659003999 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 761659004000 active site 761659004001 thiamine phosphate binding site [chemical binding]; other site 761659004002 pyrophosphate binding site [ion binding]; other site 761659004003 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 761659004004 dimer interface [polypeptide binding]; other site 761659004005 substrate binding site [chemical binding]; other site 761659004006 ATP binding site [chemical binding]; other site 761659004007 PAS domain S-box; Region: sensory_box; TIGR00229 761659004008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659004009 putative active site [active] 761659004010 heme pocket [chemical binding]; other site 761659004011 GAF domain; Region: GAF; cl17456 761659004012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659004013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659004014 dimer interface [polypeptide binding]; other site 761659004015 phosphorylation site [posttranslational modification] 761659004016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659004017 ATP binding site [chemical binding]; other site 761659004018 Mg2+ binding site [ion binding]; other site 761659004019 G-X-G motif; other site 761659004020 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 761659004021 active site residue [active] 761659004022 Protein of unknown function (DUF493); Region: DUF493; pfam04359 761659004023 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 761659004024 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 761659004025 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 761659004026 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 761659004027 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 761659004028 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 761659004029 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 761659004030 active site 761659004031 catalytic residues [active] 761659004032 metal binding site [ion binding]; metal-binding site 761659004033 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659004034 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 761659004035 putative active site [active] 761659004036 putative metal binding site [ion binding]; other site 761659004037 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 761659004038 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 761659004039 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 761659004040 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 761659004041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659004042 Walker A/P-loop; other site 761659004043 ATP binding site [chemical binding]; other site 761659004044 Q-loop/lid; other site 761659004045 ABC transporter signature motif; other site 761659004046 Walker B; other site 761659004047 D-loop; other site 761659004048 H-loop/switch region; other site 761659004049 gamma-glutamyl kinase; Provisional; Region: PRK05429 761659004050 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 761659004051 nucleotide binding site [chemical binding]; other site 761659004052 PUA domain; Region: PUA; pfam01472 761659004053 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 761659004054 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 761659004055 putative catalytic cysteine [active] 761659004056 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 761659004057 TrkA-N domain; Region: TrkA_N; pfam02254 761659004058 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659004059 TrkA-C domain; Region: TrkA_C; pfam02080 761659004060 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659004061 TrkA-N domain; Region: TrkA_N; pfam02254 761659004062 TrkA-C domain; Region: TrkA_C; pfam02080 761659004063 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 761659004064 ADP-ribose binding site [chemical binding]; other site 761659004065 glycine dehydrogenase; Provisional; Region: PRK05367 761659004066 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 761659004067 tetramer interface [polypeptide binding]; other site 761659004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659004069 catalytic residue [active] 761659004070 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 761659004071 tetramer interface [polypeptide binding]; other site 761659004072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659004073 catalytic residue [active] 761659004074 tyrosine decarboxylase; Region: PLN02880 761659004075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659004076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659004077 catalytic residue [active] 761659004078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659004079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 761659004080 putative substrate translocation pore; other site 761659004081 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 761659004082 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 761659004083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 761659004084 Family of unknown function (DUF490); Region: DUF490; pfam04357 761659004085 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659004086 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659004087 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659004088 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 761659004089 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 761659004090 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 761659004091 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 761659004092 Substrate-binding site [chemical binding]; other site 761659004093 Substrate specificity [chemical binding]; other site 761659004094 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 761659004095 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 761659004096 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 761659004097 active site 761659004098 catalytic tetrad [active] 761659004099 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 761659004100 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 761659004101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659004102 catalytic residue [active] 761659004103 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 761659004104 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 761659004105 THF binding site; other site 761659004106 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 761659004107 substrate binding site [chemical binding]; other site 761659004108 THF binding site; other site 761659004109 zinc-binding site [ion binding]; other site 761659004110 serine racemase; Region: PLN02970 761659004111 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 761659004112 tetramer interface [polypeptide binding]; other site 761659004113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659004114 catalytic residue [active] 761659004115 O-Antigen ligase; Region: Wzy_C; pfam04932 761659004116 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 761659004117 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 761659004118 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 761659004119 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 761659004120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 761659004121 Walker A motif; other site 761659004122 ATP binding site [chemical binding]; other site 761659004123 Walker B motif; other site 761659004124 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 761659004125 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 761659004126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 761659004127 Walker A motif; other site 761659004128 ATP binding site [chemical binding]; other site 761659004129 Walker B motif; other site 761659004130 Septum formation initiator; Region: DivIC; cl17659 761659004131 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 761659004132 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 761659004133 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 761659004134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 761659004135 MarR family; Region: MarR_2; pfam12802 761659004136 MarR family; Region: MarR_2; cl17246 761659004137 SnoaL-like domain; Region: SnoaL_2; pfam12680 761659004138 ADP-glucose phosphorylase; Region: PLN02643 761659004139 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 761659004140 nucleotide binding site/active site [active] 761659004141 HIT family signature motif; other site 761659004142 catalytic residue [active] 761659004143 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 761659004144 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 761659004145 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 761659004146 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 761659004147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659004148 active site 761659004149 hypothetical protein; Reviewed; Region: PRK12275 761659004150 four helix bundle protein; Region: TIGR02436 761659004151 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 761659004152 Cupin domain; Region: Cupin_2; cl17218 761659004153 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 761659004154 active site 761659004155 catalytic residues [active] 761659004156 metal binding site [ion binding]; metal-binding site 761659004157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659004158 S-adenosylmethionine binding site [chemical binding]; other site 761659004159 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 761659004160 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 761659004161 Walker A/P-loop; other site 761659004162 ATP binding site [chemical binding]; other site 761659004163 Q-loop/lid; other site 761659004164 ABC transporter signature motif; other site 761659004165 Walker B; other site 761659004166 D-loop; other site 761659004167 H-loop/switch region; other site 761659004168 putative peptidase; Provisional; Region: PRK11649 761659004169 Peptidase family M23; Region: Peptidase_M23; pfam01551 761659004170 A subfamily of the L-Asparaginase type 2-like enzymes. The wider family, a member of the Ntn-hydrolase superfamily, includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a...; Region: Asparaginase_2_like; cd04703 761659004171 catalytic nucleophile [active] 761659004172 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 761659004173 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659004174 N-terminal plug; other site 761659004175 ligand-binding site [chemical binding]; other site 761659004176 Stage II sporulation protein; Region: SpoIID; pfam08486 761659004177 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 761659004178 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 761659004179 active site 761659004180 Transposase; Region: DEDD_Tnp_IS110; pfam01548 761659004181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 761659004182 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 761659004183 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 761659004184 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 761659004185 nucleotide binding site [chemical binding]; other site 761659004186 NEF interaction site [polypeptide binding]; other site 761659004187 SBD interface [polypeptide binding]; other site 761659004188 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 761659004189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659004190 active site 761659004191 competence damage-inducible protein A; Provisional; Region: PRK00549 761659004192 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 761659004193 putative MPT binding site; other site 761659004194 Competence-damaged protein; Region: CinA; pfam02464 761659004195 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 761659004196 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 761659004197 NAD(P) binding site [chemical binding]; other site 761659004198 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 761659004199 Conserved TM helix; Region: TM_helix; pfam05552 761659004200 mechanosensitive channel MscS; Provisional; Region: PRK10334 761659004201 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659004202 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 761659004203 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 761659004204 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659004205 catalytic residues [active] 761659004206 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 761659004207 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 761659004208 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 761659004209 active site 761659004210 Zn binding site [ion binding]; other site 761659004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659004212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659004213 Ligand Binding Site [chemical binding]; other site 761659004214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659004215 Ligand Binding Site [chemical binding]; other site 761659004216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659004217 Ligand Binding Site [chemical binding]; other site 761659004218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659004219 Ligand Binding Site [chemical binding]; other site 761659004220 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 761659004221 Ligand Binding Site [chemical binding]; other site 761659004222 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 761659004223 Clp amino terminal domain; Region: Clp_N; pfam02861 761659004224 Clp amino terminal domain; Region: Clp_N; pfam02861 761659004225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659004226 Walker A motif; other site 761659004227 ATP binding site [chemical binding]; other site 761659004228 Walker B motif; other site 761659004229 arginine finger; other site 761659004230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659004231 Walker A motif; other site 761659004232 ATP binding site [chemical binding]; other site 761659004233 Walker B motif; other site 761659004234 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 761659004235 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 761659004236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659004237 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659004238 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 761659004239 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 761659004240 nucleoside/Zn binding site; other site 761659004241 dimer interface [polypeptide binding]; other site 761659004242 catalytic motif [active] 761659004243 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 761659004244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 761659004245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659004246 homodimer interface [polypeptide binding]; other site 761659004247 catalytic residue [active] 761659004248 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 761659004249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659004250 active site 761659004251 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 761659004252 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 761659004253 active site 761659004254 putative lithium-binding site [ion binding]; other site 761659004255 substrate binding site [chemical binding]; other site 761659004256 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 761659004257 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 761659004258 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 761659004259 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 761659004260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659004261 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659004262 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 761659004263 FtsX-like permease family; Region: FtsX; pfam02687 761659004264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659004265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 761659004266 Walker A/P-loop; other site 761659004267 ATP binding site [chemical binding]; other site 761659004268 Q-loop/lid; other site 761659004269 ABC transporter signature motif; other site 761659004270 Walker B; other site 761659004271 D-loop; other site 761659004272 H-loop/switch region; other site 761659004273 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 761659004274 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 761659004275 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 761659004276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659004277 active site 761659004278 Protein of unknown function DUF58; Region: DUF58; pfam01882 761659004279 Protein of unknown function DUF89; Region: DUF89; pfam01937 761659004280 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 761659004281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 761659004282 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 761659004283 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 761659004284 active site 761659004285 ribonuclease III; Reviewed; Region: rnc; PRK00102 761659004286 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 761659004287 dimerization interface [polypeptide binding]; other site 761659004288 active site 761659004289 metal binding site [ion binding]; metal-binding site 761659004290 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 761659004291 dsRNA binding site [nucleotide binding]; other site 761659004292 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 761659004293 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 761659004294 NAD(P) binding site [chemical binding]; other site 761659004295 catalytic residues [active] 761659004296 YbbR-like protein; Region: YbbR; pfam07949 761659004297 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 761659004298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 761659004299 catalytic core [active] 761659004300 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 761659004301 chorismate binding enzyme; Region: Chorismate_bind; cl10555 761659004302 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 761659004303 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 761659004304 dimer interface [polypeptide binding]; other site 761659004305 tetramer interface [polypeptide binding]; other site 761659004306 PYR/PP interface [polypeptide binding]; other site 761659004307 TPP binding site [chemical binding]; other site 761659004308 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 761659004309 TPP-binding site; other site 761659004310 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 761659004311 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 761659004312 UbiA prenyltransferase family; Region: UbiA; pfam01040 761659004313 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 761659004314 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 761659004315 metal binding site [ion binding]; metal-binding site 761659004316 substrate binding pocket [chemical binding]; other site 761659004317 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 761659004318 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 761659004319 acyl-activating enzyme (AAE) consensus motif; other site 761659004320 putative AMP binding site [chemical binding]; other site 761659004321 putative active site [active] 761659004322 putative CoA binding site [chemical binding]; other site 761659004323 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 761659004324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 761659004325 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659004326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659004327 active site 761659004328 phosphorylation site [posttranslational modification] 761659004329 intermolecular recognition site; other site 761659004330 dimerization interface [polypeptide binding]; other site 761659004331 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 761659004332 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 761659004333 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 761659004334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 761659004335 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 761659004336 anti sigma factor interaction site; other site 761659004337 regulatory phosphorylation site [posttranslational modification]; other site 761659004338 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 761659004339 OstA-like protein; Region: OstA; cl00844 761659004340 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 761659004341 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 761659004342 Walker A/P-loop; other site 761659004343 ATP binding site [chemical binding]; other site 761659004344 Q-loop/lid; other site 761659004345 ABC transporter signature motif; other site 761659004346 Walker B; other site 761659004347 D-loop; other site 761659004348 H-loop/switch region; other site 761659004349 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 761659004350 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 761659004351 glutaminase active site [active] 761659004352 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 761659004353 dimer interface [polypeptide binding]; other site 761659004354 active site 761659004355 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 761659004356 dimer interface [polypeptide binding]; other site 761659004357 active site 761659004358 peptide chain release factor 1; Validated; Region: prfA; PRK00591 761659004359 This domain is found in peptide chain release factors; Region: PCRF; smart00937 761659004360 RF-1 domain; Region: RF-1; pfam00472 761659004361 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 761659004362 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 761659004363 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 761659004364 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 761659004365 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 761659004366 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 761659004367 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659004368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659004369 catalytic residue [active] 761659004370 DnaA N-terminal domain; Region: DnaA_N; pfam11638 761659004371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659004372 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 761659004373 Walker A motif; other site 761659004374 ATP binding site [chemical binding]; other site 761659004375 Walker B motif; other site 761659004376 arginine finger; other site 761659004377 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 761659004378 DnaA box-binding interface [nucleotide binding]; other site 761659004379 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 761659004380 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 761659004381 dimer interface [polypeptide binding]; other site 761659004382 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 761659004383 active site 761659004384 Fe binding site [ion binding]; other site 761659004385 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 761659004386 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 761659004387 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 761659004388 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 761659004389 NADP binding site [chemical binding]; other site 761659004390 dimer interface [polypeptide binding]; other site 761659004391 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 761659004392 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 761659004393 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 761659004394 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 761659004395 Zn binding site [ion binding]; other site 761659004396 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 761659004397 IHF dimer interface [polypeptide binding]; other site 761659004398 IHF - DNA interface [nucleotide binding]; other site 761659004399 Double zinc ribbon; Region: DZR; pfam12773 761659004400 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 761659004401 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 761659004402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659004403 TPR motif; other site 761659004404 binding surface 761659004405 Repair protein; Region: Repair_PSII; cl01535 761659004406 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 761659004407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659004408 active site 761659004409 metal binding site [ion binding]; metal-binding site 761659004410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659004411 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 761659004412 Walker A motif; other site 761659004413 ATP binding site [chemical binding]; other site 761659004414 Walker B motif; other site 761659004415 arginine finger; other site 761659004416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659004417 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 761659004418 Fe-S metabolism associated domain; Region: SufE; cl00951 761659004419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 761659004420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659004421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659004422 catalytic residue [active] 761659004423 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 761659004424 FeS assembly protein SufD; Region: sufD; TIGR01981 761659004425 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 761659004426 FeS assembly ATPase SufC; Region: sufC; TIGR01978 761659004427 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 761659004428 Walker A/P-loop; other site 761659004429 ATP binding site [chemical binding]; other site 761659004430 Q-loop/lid; other site 761659004431 ABC transporter signature motif; other site 761659004432 Walker B; other site 761659004433 D-loop; other site 761659004434 H-loop/switch region; other site 761659004435 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 761659004436 putative ABC transporter; Region: ycf24; CHL00085 761659004437 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 761659004438 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 761659004439 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 761659004440 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 761659004441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659004442 Coenzyme A binding pocket [chemical binding]; other site 761659004443 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 761659004444 NurA nuclease; Region: NurA; smart00933 761659004445 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 761659004446 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 761659004447 malonyl-CoA binding site [chemical binding]; other site 761659004448 dimer interface [polypeptide binding]; other site 761659004449 active site 761659004450 product binding site; other site 761659004451 Lamin Tail Domain; Region: LTD; pfam00932 761659004452 Bacterial Ig-like domain; Region: Big_5; pfam13205 761659004453 Lamin Tail Domain; Region: LTD; pfam00932 761659004454 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 761659004455 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 761659004456 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 761659004457 metal binding site [ion binding]; metal-binding site 761659004458 putative dimer interface [polypeptide binding]; other site 761659004459 von Willebrand factor type A domain; Region: VWA_2; pfam13519 761659004460 metal ion-dependent adhesion site (MIDAS); other site 761659004461 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659004462 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 761659004463 active site 761659004464 catalytic residues [active] 761659004465 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 761659004466 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 761659004467 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 761659004468 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 761659004469 active site 761659004470 catalytic motif [active] 761659004471 Zn binding site [ion binding]; other site 761659004472 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 761659004473 active site 761659004474 catalytic motif [active] 761659004475 Zn binding site [ion binding]; other site 761659004476 Outer membrane efflux protein; Region: OEP; pfam02321 761659004477 Outer membrane efflux protein; Region: OEP; pfam02321 761659004478 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 761659004479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 761659004480 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659004481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659004482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659004483 Walker A/P-loop; other site 761659004484 ATP binding site [chemical binding]; other site 761659004485 Q-loop/lid; other site 761659004486 ABC transporter signature motif; other site 761659004487 Walker B; other site 761659004488 D-loop; other site 761659004489 H-loop/switch region; other site 761659004490 pantoate--beta-alanine ligase; Region: panC; TIGR00018 761659004491 Pantoate-beta-alanine ligase; Region: PanC; cd00560 761659004492 active site 761659004493 ATP-binding site [chemical binding]; other site 761659004494 pantoate-binding site; other site 761659004495 HXXH motif; other site 761659004496 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 761659004497 tetramerization interface [polypeptide binding]; other site 761659004498 active site 761659004499 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 761659004500 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 761659004501 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 761659004502 PhoH-like protein; Region: PhoH; pfam02562 761659004503 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 761659004504 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 761659004505 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 761659004506 SurA N-terminal domain; Region: SurA_N_3; cl07813 761659004507 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 761659004508 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659004509 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 761659004510 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 761659004511 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 761659004512 kynureninase; Region: kynureninase; TIGR01814 761659004513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659004514 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 761659004515 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 761659004516 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 761659004517 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 761659004518 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 761659004519 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 761659004520 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 761659004521 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 761659004522 tetramer interface [polypeptide binding]; other site 761659004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659004524 catalytic residue [active] 761659004525 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 761659004526 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 761659004527 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 761659004528 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 761659004529 dimer interface [polypeptide binding]; other site 761659004530 catalytic triad [active] 761659004531 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 761659004532 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 761659004533 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 761659004534 active site 761659004535 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 761659004536 putative acyl-acceptor binding pocket; other site 761659004537 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 761659004538 active site lid residues [active] 761659004539 substrate binding pocket [chemical binding]; other site 761659004540 catalytic residues [active] 761659004541 substrate-Mg2+ binding site; other site 761659004542 aspartate-rich region 1; other site 761659004543 aspartate-rich region 2; other site 761659004544 carotene biosynthesis associated membrane protein; Region: crt_membr_arch; TIGR03460 761659004545 WbqC-like protein family; Region: WbqC; pfam08889 761659004546 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 761659004547 trimer interface [polypeptide binding]; other site 761659004548 active site 761659004549 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 761659004550 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 761659004551 inhibitor site; inhibition site 761659004552 active site 761659004553 dimer interface [polypeptide binding]; other site 761659004554 catalytic residue [active] 761659004555 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 761659004556 ZIP Zinc transporter; Region: Zip; pfam02535 761659004557 Clp protease; Region: CLP_protease; pfam00574 761659004558 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 761659004559 oligomer interface [polypeptide binding]; other site 761659004560 active site residues [active] 761659004561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659004562 active site 761659004563 motif I; other site 761659004564 motif II; other site 761659004565 hypothetical protein; Validated; Region: PRK07883 761659004566 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 761659004567 active site 761659004568 catalytic site [active] 761659004569 substrate binding site [chemical binding]; other site 761659004570 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 761659004571 GIY-YIG motif/motif A; other site 761659004572 active site 761659004573 catalytic site [active] 761659004574 putative DNA binding site [nucleotide binding]; other site 761659004575 metal binding site [ion binding]; metal-binding site 761659004576 UvrB/uvrC motif; Region: UVR; pfam02151 761659004577 exopolyphosphatase; Region: exo_poly_only; TIGR03706 761659004578 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 761659004579 nucleotide binding site [chemical binding]; other site 761659004580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 761659004581 Zn2+ binding site [ion binding]; other site 761659004582 Mg2+ binding site [ion binding]; other site 761659004583 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 761659004584 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 761659004585 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 761659004586 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 761659004587 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 761659004588 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659004589 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 761659004590 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 761659004591 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659004592 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 761659004593 aromatic arch; other site 761659004594 DCoH dimer interaction site [polypeptide binding]; other site 761659004595 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 761659004596 DCoH tetramer interaction site [polypeptide binding]; other site 761659004597 substrate binding site [chemical binding]; other site 761659004598 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 761659004599 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659004600 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659004601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659004602 active site 761659004603 phosphorylation site [posttranslational modification] 761659004604 intermolecular recognition site; other site 761659004605 dimerization interface [polypeptide binding]; other site 761659004606 PAS domain; Region: PAS; smart00091 761659004607 PAS domain; Region: PAS_9; pfam13426 761659004608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659004609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 761659004610 Walker A motif; other site 761659004611 ATP binding site [chemical binding]; other site 761659004612 Walker B motif; other site 761659004613 arginine finger; other site 761659004614 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659004615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659004616 dimerization interface [polypeptide binding]; other site 761659004617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 761659004618 Histidine kinase; Region: HisKA_2; pfam07568 761659004619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659004620 Mg2+ binding site [ion binding]; other site 761659004621 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659004622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 761659004623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 761659004624 active site 761659004625 ATP binding site [chemical binding]; other site 761659004626 substrate binding site [chemical binding]; other site 761659004627 activation loop (A-loop); other site 761659004628 PEGA domain; Region: PEGA; pfam08308 761659004629 PEGA domain; Region: PEGA; pfam08308 761659004630 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 761659004631 NAD(P) binding site [chemical binding]; other site 761659004632 catalytic residues [active] 761659004633 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 761659004634 Isochorismatase family; Region: Isochorismatase; pfam00857 761659004635 catalytic triad [active] 761659004636 metal binding site [ion binding]; metal-binding site 761659004637 conserved cis-peptide bond; other site 761659004638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 761659004639 AAA domain; Region: AAA_33; pfam13671 761659004640 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 761659004641 active site 761659004642 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 761659004643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 761659004644 substrate binding site [chemical binding]; other site 761659004645 oxyanion hole (OAH) forming residues; other site 761659004646 trimer interface [polypeptide binding]; other site 761659004647 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 761659004648 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 761659004649 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 761659004650 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 761659004651 dimer interface [polypeptide binding]; other site 761659004652 active site 761659004653 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 761659004654 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 761659004655 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 761659004656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659004657 dimer interface [polypeptide binding]; other site 761659004658 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 761659004659 putative CheW interface [polypeptide binding]; other site 761659004660 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 761659004661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659004662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 761659004663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 761659004664 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 761659004665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 761659004666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659004667 dimer interface [polypeptide binding]; other site 761659004668 conserved gate region; other site 761659004669 putative PBP binding loops; other site 761659004670 ABC-ATPase subunit interface; other site 761659004671 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 761659004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659004673 conserved gate region; other site 761659004674 dimer interface [polypeptide binding]; other site 761659004675 putative PBP binding loops; other site 761659004676 ABC-ATPase subunit interface; other site 761659004677 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 761659004678 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 761659004679 Walker A/P-loop; other site 761659004680 ATP binding site [chemical binding]; other site 761659004681 Q-loop/lid; other site 761659004682 ABC transporter signature motif; other site 761659004683 Walker B; other site 761659004684 D-loop; other site 761659004685 H-loop/switch region; other site 761659004686 TOBE domain; Region: TOBE_2; pfam08402 761659004687 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 761659004688 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 761659004689 Walker A/P-loop; other site 761659004690 ATP binding site [chemical binding]; other site 761659004691 Q-loop/lid; other site 761659004692 ABC transporter signature motif; other site 761659004693 Walker B; other site 761659004694 D-loop; other site 761659004695 H-loop/switch region; other site 761659004696 glycerol kinase; Provisional; Region: glpK; PRK00047 761659004697 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 761659004698 N- and C-terminal domain interface [polypeptide binding]; other site 761659004699 active site 761659004700 MgATP binding site [chemical binding]; other site 761659004701 catalytic site [active] 761659004702 metal binding site [ion binding]; metal-binding site 761659004703 glycerol binding site [chemical binding]; other site 761659004704 homotetramer interface [polypeptide binding]; other site 761659004705 homodimer interface [polypeptide binding]; other site 761659004706 FBP binding site [chemical binding]; other site 761659004707 protein IIAGlc interface [polypeptide binding]; other site 761659004708 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 761659004709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659004710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659004711 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 761659004712 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 761659004713 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 761659004714 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 761659004715 AMP binding site [chemical binding]; other site 761659004716 metal binding site [ion binding]; metal-binding site 761659004717 active site 761659004718 enoyl-CoA hydratase; Provisional; Region: PRK05995 761659004719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 761659004720 substrate binding site [chemical binding]; other site 761659004721 oxyanion hole (OAH) forming residues; other site 761659004722 trimer interface [polypeptide binding]; other site 761659004723 aconitate hydratase; Validated; Region: PRK07229 761659004724 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 761659004725 substrate binding site [chemical binding]; other site 761659004726 ligand binding site [chemical binding]; other site 761659004727 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 761659004728 substrate binding site [chemical binding]; other site 761659004729 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 761659004730 aspartate-rich region 2; other site 761659004731 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 761659004732 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 761659004733 dimerization interface [polypeptide binding]; other site 761659004734 putative ATP binding site [chemical binding]; other site 761659004735 membrane protein; Provisional; Region: PRK14410 761659004736 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 761659004737 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 761659004738 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 761659004739 Divergent AAA domain; Region: AAA_4; pfam04326 761659004740 MarR family; Region: MarR_2; cl17246 761659004741 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 761659004742 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 761659004743 CAP-like domain; other site 761659004744 active site 761659004745 primary dimer interface [polypeptide binding]; other site 761659004746 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659004747 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 761659004748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659004749 Mg2+ binding site [ion binding]; other site 761659004750 G-X-G motif; other site 761659004751 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 761659004752 anchoring element; other site 761659004753 dimer interface [polypeptide binding]; other site 761659004754 ATP binding site [chemical binding]; other site 761659004755 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 761659004756 active site 761659004757 putative metal-binding site [ion binding]; other site 761659004758 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 761659004759 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 761659004760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659004761 active site 761659004762 motif I; other site 761659004763 motif II; other site 761659004764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659004765 Disulphide isomerase; Region: Disulph_isomer; pfam06491 761659004766 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 761659004767 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 761659004768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 761659004769 RNA binding surface [nucleotide binding]; other site 761659004770 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 761659004771 active site 761659004772 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 761659004773 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 761659004774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 761659004775 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 761659004776 active site 761659004777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 761659004778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 761659004779 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 761659004780 active site 761659004781 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 761659004782 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 761659004783 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 761659004784 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 761659004785 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 761659004786 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 761659004787 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 761659004788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659004789 Putative cyclase; Region: Cyclase; cl00814 761659004790 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659004791 active site 761659004792 Int/Topo IB signature motif; other site 761659004793 DNA binding site [nucleotide binding] 761659004794 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 761659004795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 761659004796 active site 761659004797 DNA binding site [nucleotide binding] 761659004798 Int/Topo IB signature motif; other site 761659004799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659004800 S-adenosylmethionine binding site [chemical binding]; other site 761659004801 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 761659004802 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 761659004803 putative NAD(P) binding site [chemical binding]; other site 761659004804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 761659004805 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 761659004806 dimerization interface [polypeptide binding]; other site 761659004807 active site 761659004808 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 761659004809 RibD C-terminal domain; Region: RibD_C; cl17279 761659004810 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 761659004811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 761659004812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 761659004813 DNA binding site [nucleotide binding] 761659004814 domain linker motif; other site 761659004815 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 761659004816 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 761659004817 ATP binding site [chemical binding]; other site 761659004818 active site 761659004819 substrate binding site [chemical binding]; other site 761659004820 Predicted amidohydrolase [General function prediction only]; Region: COG0388 761659004821 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577 761659004822 putative active site [active] 761659004823 catalytic triad [active] 761659004824 dimer interface [polypeptide binding]; other site 761659004825 putative tetramer interface [polypeptide binding]; other site 761659004826 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 761659004827 Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971 761659004828 catalytic triad [active] 761659004829 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 761659004830 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 761659004831 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 761659004832 Glutamate binding site [chemical binding]; other site 761659004833 NAD binding site [chemical binding]; other site 761659004834 catalytic residues [active] 761659004835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 761659004836 DNA-binding site [nucleotide binding]; DNA binding site 761659004837 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 761659004838 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 761659004839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 761659004840 Zn2+ binding site [ion binding]; other site 761659004841 Mg2+ binding site [ion binding]; other site 761659004842 Helix-turn-helix domain; Region: HTH_25; pfam13413 761659004843 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 761659004844 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659004845 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 761659004846 NRDE protein; Region: NRDE; pfam05742 761659004847 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 761659004848 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 761659004849 active site 761659004850 dimer interface [polypeptide binding]; other site 761659004851 metal binding site [ion binding]; metal-binding site 761659004852 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 761659004853 Family of unknown function (DUF490); Region: DUF490; pfam04357 761659004854 ribonuclease R; Region: RNase_R; TIGR02063 761659004855 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 761659004856 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 761659004857 RNB domain; Region: RNB; pfam00773 761659004858 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 761659004859 RNA binding site [nucleotide binding]; other site 761659004860 Uncharacterized conserved protein [Function unknown]; Region: COG4198 761659004861 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 761659004862 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 761659004863 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 761659004864 active site 761659004865 recombinase A; Provisional; Region: recA; PRK09354 761659004866 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 761659004867 hexamer interface [polypeptide binding]; other site 761659004868 Walker A motif; other site 761659004869 ATP binding site [chemical binding]; other site 761659004870 Walker B motif; other site 761659004871 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 761659004872 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659004873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659004874 active site 761659004875 phosphorylation site [posttranslational modification] 761659004876 intermolecular recognition site; other site 761659004877 dimerization interface [polypeptide binding]; other site 761659004878 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 761659004879 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 761659004880 putative active site [active] 761659004881 catalytic site [active] 761659004882 putative metal binding site [ion binding]; other site 761659004883 oligomer interface [polypeptide binding]; other site 761659004884 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 761659004885 active site 761659004886 DNA polymerase IV; Validated; Region: PRK02406 761659004887 DNA binding site [nucleotide binding] 761659004888 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 761659004889 GIY-YIG motif/motif A; other site 761659004890 putative active site [active] 761659004891 putative metal binding site [ion binding]; other site 761659004892 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 761659004893 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 761659004894 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 761659004895 motif 1; other site 761659004896 active site 761659004897 motif 2; other site 761659004898 motif 3; other site 761659004899 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 761659004900 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 761659004901 active site 761659004902 DNA binding site [nucleotide binding] 761659004903 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 761659004904 putative acyltransferase; Provisional; Region: PRK05790 761659004905 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 761659004906 dimer interface [polypeptide binding]; other site 761659004907 active site 761659004908 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 761659004909 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 761659004910 catalytic residues [active] 761659004911 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 761659004912 putative active site [active] 761659004913 Zn binding site [ion binding]; other site 761659004914 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 761659004915 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 761659004916 MOFRL family; Region: MOFRL; pfam05161 761659004917 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 761659004918 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 761659004919 thiamine phosphate binding site [chemical binding]; other site 761659004920 active site 761659004921 pyrophosphate binding site [ion binding]; other site 761659004922 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 761659004923 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 761659004924 active site 761659004925 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 761659004926 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 761659004927 domain interfaces; other site 761659004928 active site 761659004929 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 761659004930 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 761659004931 tRNA; other site 761659004932 putative tRNA binding site [nucleotide binding]; other site 761659004933 putative NADP binding site [chemical binding]; other site 761659004934 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 761659004935 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 761659004936 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 761659004937 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 761659004938 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 761659004939 active site 761659004940 HIGH motif; other site 761659004941 KMSKS motif; other site 761659004942 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 761659004943 tRNA binding surface [nucleotide binding]; other site 761659004944 anticodon binding site; other site 761659004945 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 761659004946 dimer interface [polypeptide binding]; other site 761659004947 putative tRNA-binding site [nucleotide binding]; other site 761659004948 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 761659004949 4-fold oligomerization interface [polypeptide binding]; other site 761659004950 putative active site pocket [active] 761659004951 metal binding residues [ion binding]; metal-binding site 761659004952 3-fold/trimer interface [polypeptide binding]; other site 761659004953 pyrroline-5-carboxylate reductase; Region: PLN02688 761659004954 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 761659004955 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 761659004956 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 761659004957 putative active site [active] 761659004958 oxyanion strand; other site 761659004959 catalytic triad [active] 761659004960 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 761659004961 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 761659004962 catalytic residues [active] 761659004963 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 761659004964 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 761659004965 substrate binding site [chemical binding]; other site 761659004966 glutamase interaction surface [polypeptide binding]; other site 761659004967 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 761659004968 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 761659004969 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 761659004970 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 761659004971 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 761659004972 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 761659004973 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 761659004974 malate dehydrogenase; Reviewed; Region: PRK06223 761659004975 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 761659004976 NAD(P) binding site [chemical binding]; other site 761659004977 dimer interface [polypeptide binding]; other site 761659004978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 761659004979 substrate binding site [chemical binding]; other site 761659004980 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 761659004981 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 761659004982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659004983 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 761659004984 dimer interface [polypeptide binding]; other site 761659004985 substrate binding site [chemical binding]; other site 761659004986 metal binding site [ion binding]; metal-binding site 761659004987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659004988 TAP-like protein; Region: Abhydrolase_4; pfam08386 761659004989 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 761659004990 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 761659004991 active site 761659004992 catalytic tetrad [active] 761659004993 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 761659004994 AbgT putative transporter family; Region: ABG_transport; cl17431 761659004995 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 761659004996 PIN domain; Region: PIN_3; pfam13470 761659004997 HicB family; Region: HicB; pfam05534 761659004998 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 761659004999 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 761659005000 GIY-YIG motif/motif A; other site 761659005001 active site 761659005002 catalytic site [active] 761659005003 putative DNA binding site [nucleotide binding]; other site 761659005004 metal binding site [ion binding]; metal-binding site 761659005005 UvrB/uvrC motif; Region: UVR; pfam02151 761659005006 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 761659005007 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 761659005008 DNA binding site [nucleotide binding] 761659005009 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 761659005010 catalytic residues [active] 761659005011 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005013 binding surface 761659005014 TPR motif; other site 761659005015 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005017 binding surface 761659005018 TPR motif; other site 761659005019 Outer membrane lipoprotein; Region: YfiO; pfam13525 761659005020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005021 binding surface 761659005022 TPR motif; other site 761659005023 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005024 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005025 Bacterial transcriptional activator domain; Region: BTAD; smart01043 761659005026 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 761659005027 IHF dimer interface [polypeptide binding]; other site 761659005028 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 761659005029 Sporulation related domain; Region: SPOR; pfam05036 761659005030 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 761659005031 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 761659005032 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 761659005033 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 761659005034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659005035 Walker A motif; other site 761659005036 ATP binding site [chemical binding]; other site 761659005037 Walker B motif; other site 761659005038 arginine finger; other site 761659005039 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 761659005040 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 761659005041 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 761659005042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659005043 S-adenosylmethionine binding site [chemical binding]; other site 761659005044 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 761659005045 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 761659005046 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 761659005047 metal-binding site [ion binding] 761659005048 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 761659005049 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 761659005050 metal-binding site [ion binding] 761659005051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 761659005052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659005053 active site 761659005054 motif I; other site 761659005055 motif II; other site 761659005056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 761659005057 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 761659005058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659005059 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 761659005060 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 761659005061 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 761659005062 Uncharacterized conserved protein [Function unknown]; Region: COG3339 761659005063 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 761659005064 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 761659005065 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 761659005066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 761659005067 FOG: CBS domain [General function prediction only]; Region: COG0517 761659005068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 761659005069 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 761659005070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005071 binding surface 761659005072 TPR motif; other site 761659005073 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 761659005074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005075 TPR motif; other site 761659005076 binding surface 761659005077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005078 binding surface 761659005079 TPR motif; other site 761659005080 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 761659005081 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 761659005082 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 761659005083 Peptidase family M23; Region: Peptidase_M23; pfam01551 761659005084 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 761659005085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659005086 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 761659005087 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 761659005088 Peptidase family M1; Region: Peptidase_M1; pfam01433 761659005089 Zn binding site [ion binding]; other site 761659005090 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 761659005091 HSP70 interaction site [polypeptide binding]; other site 761659005092 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 761659005093 MutS domain I; Region: MutS_I; pfam01624 761659005094 MutS domain II; Region: MutS_II; pfam05188 761659005095 MutS domain III; Region: MutS_III; pfam05192 761659005096 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 761659005097 Walker A/P-loop; other site 761659005098 ATP binding site [chemical binding]; other site 761659005099 Q-loop/lid; other site 761659005100 ABC transporter signature motif; other site 761659005101 Walker B; other site 761659005102 D-loop; other site 761659005103 H-loop/switch region; other site 761659005104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659005105 Ligand Binding Site [chemical binding]; other site 761659005106 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 761659005107 ATP-NAD kinase; Region: NAD_kinase; pfam01513 761659005108 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 761659005109 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 761659005110 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 761659005111 protein binding site [polypeptide binding]; other site 761659005112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 761659005113 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 761659005114 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 761659005115 dimer interface [polypeptide binding]; other site 761659005116 active site 761659005117 metal binding site [ion binding]; metal-binding site 761659005118 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 761659005119 prephenate dehydrogenase; Validated; Region: PRK06545 761659005120 prephenate dehydrogenase; Validated; Region: PRK08507 761659005121 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 761659005122 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 761659005123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 761659005124 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 761659005125 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 761659005126 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 761659005127 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 761659005128 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 761659005129 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 761659005130 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 761659005131 ATP-grasp domain; Region: ATP-grasp; pfam02222 761659005132 AIR carboxylase; Region: AIRC; pfam00731 761659005133 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659005134 Interdomain contacts; other site 761659005135 Cytokine receptor motif; other site 761659005136 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 761659005137 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 761659005138 active site 761659005139 HIGH motif; other site 761659005140 dimer interface [polypeptide binding]; other site 761659005141 KMSKS motif; other site 761659005142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 761659005143 RNA binding surface [nucleotide binding]; other site 761659005144 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 761659005145 SmpB-tmRNA interface; other site 761659005146 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 761659005147 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 761659005148 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 761659005149 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 761659005150 RimM N-terminal domain; Region: RimM; pfam01782 761659005151 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 761659005152 signal recognition particle protein; Provisional; Region: PRK10867 761659005153 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 761659005154 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 761659005155 P loop; other site 761659005156 GTP binding site [chemical binding]; other site 761659005157 Signal peptide binding domain; Region: SRP_SPB; pfam02978 761659005158 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 761659005159 PspC domain; Region: PspC; pfam04024 761659005160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 761659005161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 761659005162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 761659005163 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 761659005164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 761659005165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 761659005166 DNA polymerase I; Provisional; Region: PRK05755 761659005167 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 761659005168 active site 761659005169 metal binding site 1 [ion binding]; metal-binding site 761659005170 putative 5' ssDNA interaction site; other site 761659005171 metal binding site 3; metal-binding site 761659005172 metal binding site 2 [ion binding]; metal-binding site 761659005173 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 761659005174 putative DNA binding site [nucleotide binding]; other site 761659005175 putative metal binding site [ion binding]; other site 761659005176 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 761659005177 active site 761659005178 catalytic site [active] 761659005179 substrate binding site [chemical binding]; other site 761659005180 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 761659005181 active site 761659005182 DNA binding site [nucleotide binding] 761659005183 catalytic site [active] 761659005184 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 761659005185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659005186 motif II; other site 761659005187 PAS domain S-box; Region: sensory_box; TIGR00229 761659005188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659005189 putative active site [active] 761659005190 heme pocket [chemical binding]; other site 761659005191 PAS fold; Region: PAS_4; pfam08448 761659005192 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 761659005193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 761659005194 putative active site [active] 761659005195 heme pocket [chemical binding]; other site 761659005196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659005197 putative active site [active] 761659005198 heme pocket [chemical binding]; other site 761659005199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659005200 dimer interface [polypeptide binding]; other site 761659005201 phosphorylation site [posttranslational modification] 761659005202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659005203 ATP binding site [chemical binding]; other site 761659005204 Mg2+ binding site [ion binding]; other site 761659005205 G-X-G motif; other site 761659005206 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 761659005207 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 761659005208 active site 761659005209 substrate binding site [chemical binding]; other site 761659005210 cosubstrate binding site; other site 761659005211 catalytic site [active] 761659005212 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 761659005213 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 761659005214 purine monophosphate binding site [chemical binding]; other site 761659005215 dimer interface [polypeptide binding]; other site 761659005216 putative catalytic residues [active] 761659005217 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 761659005218 rod shape-determining protein MreB; Provisional; Region: PRK13927 761659005219 MreB and similar proteins; Region: MreB_like; cd10225 761659005220 nucleotide binding site [chemical binding]; other site 761659005221 Mg binding site [ion binding]; other site 761659005222 putative protofilament interaction site [polypeptide binding]; other site 761659005223 RodZ interaction site [polypeptide binding]; other site 761659005224 rod shape-determining protein MreC; Provisional; Region: PRK13922 761659005225 rod shape-determining protein MreC; Region: MreC; pfam04085 761659005226 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 761659005227 active site 761659005228 HslU subunit interaction site [polypeptide binding]; other site 761659005229 LabA_like proteins; Region: LabA_like; cd06167 761659005230 putative metal binding site [ion binding]; other site 761659005231 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 761659005232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 761659005233 Walker A motif; other site 761659005234 ATP binding site [chemical binding]; other site 761659005235 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 761659005236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 761659005237 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 761659005238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659005239 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 761659005240 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 761659005241 trimer interface [polypeptide binding]; other site 761659005242 putative metal binding site [ion binding]; other site 761659005243 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 761659005244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 761659005245 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 761659005246 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 761659005247 homotrimer interaction site [polypeptide binding]; other site 761659005248 zinc binding site [ion binding]; other site 761659005249 CDP-binding sites; other site 761659005250 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 761659005251 substrate binding site; other site 761659005252 dimer interface; other site 761659005253 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 761659005254 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 761659005255 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 761659005256 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 761659005257 cobalamin binding residues [chemical binding]; other site 761659005258 putative BtuC binding residues; other site 761659005259 dimer interface [polypeptide binding]; other site 761659005260 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 761659005261 Amidase; Region: Amidase; cl11426 761659005262 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 761659005263 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 761659005264 putative active site [active] 761659005265 putative NTP binding site [chemical binding]; other site 761659005266 putative nucleic acid binding site [nucleotide binding]; other site 761659005267 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 761659005268 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 761659005269 active site 761659005270 potential frameshift: common BLAST hit: gi|83816497|ref|YP_445776.1| anion permease 761659005271 Phosphate transporter family; Region: PHO4; cl00396 761659005272 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 761659005273 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 761659005274 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 761659005275 G1 box; other site 761659005276 putative GEF interaction site [polypeptide binding]; other site 761659005277 GTP/Mg2+ binding site [chemical binding]; other site 761659005278 Switch I region; other site 761659005279 G2 box; other site 761659005280 G3 box; other site 761659005281 Switch II region; other site 761659005282 G4 box; other site 761659005283 G5 box; other site 761659005284 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 761659005285 Predicted membrane protein [Function unknown]; Region: COG3174 761659005286 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 761659005287 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 761659005288 Uncharacterized conserved protein [Function unknown]; Region: COG1434 761659005289 putative active site [active] 761659005290 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 761659005291 substrate binding site [chemical binding]; other site 761659005292 putative active site [active] 761659005293 redox center [active] 761659005294 Thioredoxin; Region: Thioredoxin_4; pfam13462 761659005295 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 761659005296 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 761659005297 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 761659005298 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 761659005299 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 761659005300 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 761659005301 active site 761659005302 HIGH motif; other site 761659005303 dimer interface [polypeptide binding]; other site 761659005304 KMSKS motif; other site 761659005305 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 761659005306 Glutamine amidotransferase class-I; Region: GATase; pfam00117 761659005307 glutamine binding [chemical binding]; other site 761659005308 catalytic triad [active] 761659005309 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 761659005310 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 761659005311 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 761659005312 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 761659005313 active site 761659005314 ribulose/triose binding site [chemical binding]; other site 761659005315 phosphate binding site [ion binding]; other site 761659005316 substrate (anthranilate) binding pocket [chemical binding]; other site 761659005317 product (indole) binding pocket [chemical binding]; other site 761659005318 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 761659005319 active site 761659005320 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 761659005321 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 761659005322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659005323 catalytic residue [active] 761659005324 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 761659005325 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 761659005326 substrate binding site [chemical binding]; other site 761659005327 active site 761659005328 catalytic residues [active] 761659005329 heterodimer interface [polypeptide binding]; other site 761659005330 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 761659005331 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 761659005332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659005333 ATP binding site [chemical binding]; other site 761659005334 putative Mg++ binding site [ion binding]; other site 761659005335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659005336 nucleotide binding region [chemical binding]; other site 761659005337 ATP-binding site [chemical binding]; other site 761659005338 EamA-like transporter family; Region: EamA; pfam00892 761659005339 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 761659005340 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 761659005341 isocitrate dehydrogenase; Validated; Region: PRK06451 761659005342 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 761659005343 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 761659005344 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 761659005345 hypothetical protein; Provisional; Region: PRK08609 761659005346 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 761659005347 metal binding triad [ion binding]; metal-binding site 761659005348 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 761659005349 active site 761659005350 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 761659005351 acetyl-CoA synthetase; Provisional; Region: PRK00174 761659005352 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 761659005353 active site 761659005354 CoA binding site [chemical binding]; other site 761659005355 acyl-activating enzyme (AAE) consensus motif; other site 761659005356 AMP binding site [chemical binding]; other site 761659005357 acetate binding site [chemical binding]; other site 761659005358 aminodeoxychorismate synthase; Provisional; Region: PRK07508 761659005359 chorismate binding enzyme; Region: Chorismate_bind; cl10555 761659005360 hypothetical protein; Provisional; Region: PRK07546 761659005361 substrate-cofactor binding pocket; other site 761659005362 homodimer interface [polypeptide binding]; other site 761659005363 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 761659005364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659005365 catalytic residue [active] 761659005366 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 761659005367 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 761659005368 putative NAD(P) binding site [chemical binding]; other site 761659005369 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 761659005370 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 761659005371 FMN binding site [chemical binding]; other site 761659005372 active site 761659005373 substrate binding site [chemical binding]; other site 761659005374 catalytic residue [active] 761659005375 Pirin; Region: Pirin; pfam02678 761659005376 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 761659005377 B12 binding site [chemical binding]; other site 761659005378 cobalt ligand [ion binding]; other site 761659005379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 761659005380 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 761659005381 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 761659005382 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659005383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659005384 NAD(P) binding site [chemical binding]; other site 761659005385 active site 761659005386 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 761659005387 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 761659005388 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659005389 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 761659005390 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 761659005391 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 761659005392 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 761659005393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659005394 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 761659005395 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 761659005396 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 761659005397 amphi-Trp domain; Region: amphi-Trp; TIGR04354 761659005398 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 761659005399 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 761659005400 acyl-coenzyme A oxidase; Region: PLN02636 761659005401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 761659005402 active site 761659005403 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 761659005404 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 761659005405 substrate binding site [chemical binding]; other site 761659005406 active site 761659005407 Dienelactone hydrolase family; Region: DLH; pfam01738 761659005408 PGAP1-like protein; Region: PGAP1; pfam07819 761659005409 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 761659005410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 761659005411 Zn2+ binding site [ion binding]; other site 761659005412 Mg2+ binding site [ion binding]; other site 761659005413 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 761659005414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659005415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659005416 DNA binding residues [nucleotide binding] 761659005417 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 761659005418 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 761659005419 substrate binding site [chemical binding]; other site 761659005420 tetramer interface [polypeptide binding]; other site 761659005421 catalytic residue [active] 761659005422 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 761659005423 active site 761659005424 homodimer interface [polypeptide binding]; other site 761659005425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659005426 active site 761659005427 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 761659005428 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 761659005429 Ligand Binding Site [chemical binding]; other site 761659005430 TilS substrate C-terminal domain; Region: TilS_C; smart00977 761659005431 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 761659005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659005433 ATP binding site [chemical binding]; other site 761659005434 Mg2+ binding site [ion binding]; other site 761659005435 G-X-G motif; other site 761659005436 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 761659005437 ATP binding site [chemical binding]; other site 761659005438 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 761659005439 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 761659005440 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 761659005441 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 761659005442 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 761659005443 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 761659005444 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 761659005445 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 761659005446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659005447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659005448 ATP binding site [chemical binding]; other site 761659005449 G-X-G motif; other site 761659005450 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 761659005451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659005452 active site 761659005453 phosphorylation site [posttranslational modification] 761659005454 intermolecular recognition site; other site 761659005455 dimerization interface [polypeptide binding]; other site 761659005456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659005457 Walker A motif; other site 761659005458 ATP binding site [chemical binding]; other site 761659005459 Walker B motif; other site 761659005460 arginine finger; other site 761659005461 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659005462 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659005463 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 761659005464 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659005465 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 761659005466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659005467 FtsX-like permease family; Region: FtsX; pfam02687 761659005468 FtsX-like permease family; Region: FtsX; pfam02687 761659005469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659005470 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 761659005471 Walker A/P-loop; other site 761659005472 ATP binding site [chemical binding]; other site 761659005473 Q-loop/lid; other site 761659005474 ABC transporter signature motif; other site 761659005475 Walker B; other site 761659005476 D-loop; other site 761659005477 H-loop/switch region; other site 761659005478 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 761659005479 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659005480 FtsX-like permease family; Region: FtsX; pfam02687 761659005481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659005482 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 761659005483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 761659005484 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 761659005485 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 761659005486 intracellular protease, PfpI family; Region: PfpI; TIGR01382 761659005487 conserved cys residue [active] 761659005488 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 761659005489 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 761659005490 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 761659005491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659005492 Uncharacterized conserved protein [Function unknown]; Region: COG3268 761659005493 NAD(P) binding site [chemical binding]; other site 761659005494 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 761659005495 active site 761659005496 Zn binding site [ion binding]; other site 761659005497 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 761659005498 DNA-binding site [nucleotide binding]; DNA binding site 761659005499 RNA-binding motif; other site 761659005500 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 761659005501 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 761659005502 substrate binding site [chemical binding]; other site 761659005503 nucleotide binding site [chemical binding]; other site 761659005504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 761659005505 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 761659005506 active site 761659005507 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 761659005508 active site 761659005509 dimer interface [polypeptide binding]; other site 761659005510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659005511 Ligand Binding Site [chemical binding]; other site 761659005512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659005513 Ligand Binding Site [chemical binding]; other site 761659005514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659005515 Ligand Binding Site [chemical binding]; other site 761659005516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659005517 Ligand Binding Site [chemical binding]; other site 761659005518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 761659005519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659005521 putative substrate translocation pore; other site 761659005522 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 761659005523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 761659005524 inhibitor-cofactor binding pocket; inhibition site 761659005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659005526 catalytic residue [active] 761659005527 Methyltransferase domain; Region: Methyltransf_23; pfam13489 761659005528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659005529 S-adenosylmethionine binding site [chemical binding]; other site 761659005530 Ferrochelatase; Region: Ferrochelatase; pfam00762 761659005531 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 761659005532 C-terminal domain interface [polypeptide binding]; other site 761659005533 active site 761659005534 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 761659005535 active site 761659005536 N-terminal domain interface [polypeptide binding]; other site 761659005537 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 761659005538 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 761659005539 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 761659005540 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 761659005541 active site 761659005542 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 761659005543 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 761659005544 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 761659005545 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 761659005546 nucleotide binding site [chemical binding]; other site 761659005547 substrate binding site [chemical binding]; other site 761659005548 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 761659005549 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 761659005550 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 761659005551 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 761659005552 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 761659005553 metal binding site [ion binding]; metal-binding site 761659005554 photolyase PhrII; Region: phr2; TIGR00591 761659005555 DNA photolyase; Region: DNA_photolyase; pfam00875 761659005556 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 761659005557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 761659005558 Integral membrane protein DUF92; Region: DUF92; pfam01940 761659005559 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 761659005560 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 761659005561 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 761659005562 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 761659005563 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 761659005564 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 761659005565 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 761659005566 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 761659005567 DNA binding site [nucleotide binding] 761659005568 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 761659005569 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 761659005570 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 761659005571 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 761659005572 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 761659005573 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 761659005574 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 761659005575 RPB3 interaction site [polypeptide binding]; other site 761659005576 RPB1 interaction site [polypeptide binding]; other site 761659005577 RPB11 interaction site [polypeptide binding]; other site 761659005578 RPB10 interaction site [polypeptide binding]; other site 761659005579 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 761659005580 core dimer interface [polypeptide binding]; other site 761659005581 peripheral dimer interface [polypeptide binding]; other site 761659005582 L10 interface [polypeptide binding]; other site 761659005583 L11 interface [polypeptide binding]; other site 761659005584 putative EF-Tu interaction site [polypeptide binding]; other site 761659005585 putative EF-G interaction site [polypeptide binding]; other site 761659005586 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 761659005587 23S rRNA interface [nucleotide binding]; other site 761659005588 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 761659005589 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 761659005590 mRNA/rRNA interface [nucleotide binding]; other site 761659005591 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 761659005592 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 761659005593 23S rRNA interface [nucleotide binding]; other site 761659005594 L7/L12 interface [polypeptide binding]; other site 761659005595 putative thiostrepton binding site; other site 761659005596 L25 interface [polypeptide binding]; other site 761659005597 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 761659005598 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 761659005599 putative homodimer interface [polypeptide binding]; other site 761659005600 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 761659005601 heterodimer interface [polypeptide binding]; other site 761659005602 homodimer interface [polypeptide binding]; other site 761659005603 elongation factor Tu; Reviewed; Region: PRK00049 761659005604 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 761659005605 G1 box; other site 761659005606 GEF interaction site [polypeptide binding]; other site 761659005607 GTP/Mg2+ binding site [chemical binding]; other site 761659005608 Switch I region; other site 761659005609 G2 box; other site 761659005610 G3 box; other site 761659005611 Switch II region; other site 761659005612 G4 box; other site 761659005613 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 761659005614 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 761659005615 Antibiotic Binding Site [chemical binding]; other site 761659005616 potential frameshift: common BLAST hit: gi|83815489|ref|YP_445884.1| sodium-dependent transporter 761659005617 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 761659005618 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 761659005619 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 761659005620 TrkA-C domain; Region: TrkA_C; pfam02080 761659005621 TrkA-C domain; Region: TrkA_C; pfam02080 761659005622 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 761659005623 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659005624 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 761659005625 ScpA/B protein; Region: ScpA_ScpB; cl00598 761659005626 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 761659005627 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 761659005628 NAD binding site [chemical binding]; other site 761659005629 homodimer interface [polypeptide binding]; other site 761659005630 active site 761659005631 substrate binding site [chemical binding]; other site 761659005632 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 761659005633 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 761659005634 RNase E interface [polypeptide binding]; other site 761659005635 trimer interface [polypeptide binding]; other site 761659005636 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 761659005637 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 761659005638 RNase E interface [polypeptide binding]; other site 761659005639 trimer interface [polypeptide binding]; other site 761659005640 active site 761659005641 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 761659005642 putative nucleic acid binding region [nucleotide binding]; other site 761659005643 G-X-X-G motif; other site 761659005644 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 761659005645 RNA binding site [nucleotide binding]; other site 761659005646 domain interface; other site 761659005647 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 761659005648 16S/18S rRNA binding site [nucleotide binding]; other site 761659005649 S13e-L30e interaction site [polypeptide binding]; other site 761659005650 25S rRNA binding site [nucleotide binding]; other site 761659005651 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 761659005652 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 761659005653 active site 761659005654 Riboflavin kinase; Region: Flavokinase; pfam01687 761659005655 Ribosome-binding factor A; Region: RBFA; pfam02033 761659005656 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 761659005657 translation initiation factor IF-2; Region: IF-2; TIGR00487 761659005658 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 761659005659 G1 box; other site 761659005660 putative GEF interaction site [polypeptide binding]; other site 761659005661 GTP/Mg2+ binding site [chemical binding]; other site 761659005662 Switch I region; other site 761659005663 G2 box; other site 761659005664 G3 box; other site 761659005665 Switch II region; other site 761659005666 G4 box; other site 761659005667 G5 box; other site 761659005668 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 761659005669 Translation-initiation factor 2; Region: IF-2; pfam11987 761659005670 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 761659005671 transcription termination factor NusA; Region: NusA; TIGR01953 761659005672 NusA N-terminal domain; Region: NusA_N; pfam08529 761659005673 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 761659005674 RNA binding site [nucleotide binding]; other site 761659005675 homodimer interface [polypeptide binding]; other site 761659005676 NusA-like KH domain; Region: KH_5; pfam13184 761659005677 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 761659005678 G-X-X-G motif; other site 761659005679 ribosome maturation protein RimP; Reviewed; Region: PRK00092 761659005680 hypothetical protein; Provisional; Region: PRK14641 761659005681 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 761659005682 putative oligomer interface [polypeptide binding]; other site 761659005683 putative RNA binding site [nucleotide binding]; other site 761659005684 peptide chain release factor 2; Region: prfB; TIGR00020 761659005685 PCRF domain; Region: PCRF; pfam03462 761659005686 RF-1 domain; Region: RF-1; pfam00472 761659005687 hypothetical protein; Validated; Region: PRK07682 761659005688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 761659005689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659005690 homodimer interface [polypeptide binding]; other site 761659005691 catalytic residue [active] 761659005692 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 761659005693 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 761659005694 NAD binding site [chemical binding]; other site 761659005695 catalytic residues [active] 761659005696 Uncharacterized conserved protein [Function unknown]; Region: COG2454 761659005697 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 761659005698 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 761659005699 Malic enzyme, N-terminal domain; Region: malic; pfam00390 761659005700 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 761659005701 putative NAD(P) binding site [chemical binding]; other site 761659005702 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 761659005703 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 761659005704 RNA binding site [nucleotide binding]; other site 761659005705 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 761659005706 RNA binding site [nucleotide binding]; other site 761659005707 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 761659005708 RNA binding site [nucleotide binding]; other site 761659005709 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 761659005710 RNA binding site [nucleotide binding]; other site 761659005711 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 761659005712 RNA binding site [nucleotide binding]; other site 761659005713 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 761659005714 RNA binding site [nucleotide binding]; other site 761659005715 cytidylate kinase; Provisional; Region: cmk; PRK00023 761659005716 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 761659005717 CMP-binding site; other site 761659005718 The sites determining sugar specificity; other site 761659005719 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 761659005720 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 761659005721 heterodimer interface [polypeptide binding]; other site 761659005722 substrate interaction site [chemical binding]; other site 761659005723 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 761659005724 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 761659005725 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 761659005726 active site 761659005727 substrate binding site [chemical binding]; other site 761659005728 coenzyme B12 binding site [chemical binding]; other site 761659005729 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 761659005730 B12 binding site [chemical binding]; other site 761659005731 cobalt ligand [ion binding]; other site 761659005732 membrane ATPase/protein kinase; Provisional; Region: PRK09435 761659005733 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 761659005734 Walker A; other site 761659005735 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 761659005736 G4 box; other site 761659005737 G5 box; other site 761659005738 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 761659005739 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659005740 active site 761659005741 HIGH motif; other site 761659005742 nucleotide binding site [chemical binding]; other site 761659005743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659005744 active site 761659005745 KMSKS motif; other site 761659005746 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 761659005747 GatB domain; Region: GatB_Yqey; smart00845 761659005748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 761659005749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 761659005750 HIGH motif; other site 761659005751 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 761659005752 active site 761659005753 KMSKS motif; other site 761659005754 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659005755 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659005756 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 761659005757 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 761659005758 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 761659005759 SurA N-terminal domain; Region: SurA_N; pfam09312 761659005760 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659005761 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659005762 MoxR-like ATPases [General function prediction only]; Region: COG0714 761659005763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659005764 Walker A motif; other site 761659005765 ATP binding site [chemical binding]; other site 761659005766 Walker B motif; other site 761659005767 arginine finger; other site 761659005768 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 761659005769 FAD binding pocket [chemical binding]; other site 761659005770 FAD binding motif [chemical binding]; other site 761659005771 phosphate binding motif [ion binding]; other site 761659005772 beta-alpha-beta structure motif; other site 761659005773 NAD binding pocket [chemical binding]; other site 761659005774 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 761659005775 tellurium resistance terB-like protein; Region: terB_like; cd07177 761659005776 metal binding site [ion binding]; metal-binding site 761659005777 tellurium resistance terB-like protein; Region: terB_like; cd07177 761659005778 metal binding site [ion binding]; metal-binding site 761659005779 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 761659005780 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 761659005781 proline aminopeptidase P II; Provisional; Region: PRK10879 761659005782 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 761659005783 active site 761659005784 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 761659005785 Family description; Region: UvrD_C_2; pfam13538 761659005786 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 761659005787 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 761659005788 Staphylococcal nuclease homologues; Region: SNc; smart00318 761659005789 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 761659005790 Catalytic site; other site 761659005791 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 761659005792 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 761659005793 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 761659005794 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 761659005795 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 761659005796 methionine sulfoxide reductase B; Provisional; Region: PRK00222 761659005797 SelR domain; Region: SelR; pfam01641 761659005798 FtsH Extracellular; Region: FtsH_ext; pfam06480 761659005799 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 761659005800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659005801 Walker B motif; other site 761659005802 arginine finger; other site 761659005803 Peptidase family M41; Region: Peptidase_M41; pfam01434 761659005804 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 761659005805 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 761659005806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 761659005807 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 761659005808 acyl-activating enzyme (AAE) consensus motif; other site 761659005809 putative AMP binding site [chemical binding]; other site 761659005810 putative active site [active] 761659005811 putative CoA binding site [chemical binding]; other site 761659005812 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659005813 hypothetical protein; Reviewed; Region: PRK12497 761659005814 Predicted transcriptional regulators [Transcription]; Region: COG1510 761659005815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659005816 dimerization interface [polypeptide binding]; other site 761659005817 putative DNA binding site [nucleotide binding]; other site 761659005818 putative Zn2+ binding site [ion binding]; other site 761659005819 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 761659005820 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 761659005821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659005822 dimer interface [polypeptide binding]; other site 761659005823 phosphorylation site [posttranslational modification] 761659005824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659005825 ATP binding site [chemical binding]; other site 761659005826 Mg2+ binding site [ion binding]; other site 761659005827 G-X-G motif; other site 761659005828 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 761659005829 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 761659005830 GDP-binding site [chemical binding]; other site 761659005831 ACT binding site; other site 761659005832 IMP binding site; other site 761659005833 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 761659005834 Protein export membrane protein; Region: SecD_SecF; pfam02355 761659005835 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 761659005836 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 761659005837 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 761659005838 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 761659005839 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659005840 Serine hydrolase; Region: Ser_hydrolase; cl17834 761659005841 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 761659005842 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 761659005843 putative dimer interface [polypeptide binding]; other site 761659005844 putative anticodon binding site; other site 761659005845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 761659005846 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 761659005847 motif 1; other site 761659005848 dimer interface [polypeptide binding]; other site 761659005849 active site 761659005850 motif 2; other site 761659005851 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 761659005852 active site 761659005853 motif 3; other site 761659005854 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 761659005855 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 761659005856 active site 761659005857 substrate-binding site [chemical binding]; other site 761659005858 metal-binding site [ion binding] 761659005859 ATP binding site [chemical binding]; other site 761659005860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659005861 Coenzyme A binding pocket [chemical binding]; other site 761659005862 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 761659005863 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 761659005864 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 761659005865 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 761659005866 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 761659005867 homodimer interface [polypeptide binding]; other site 761659005868 NADP binding site [chemical binding]; other site 761659005869 substrate binding site [chemical binding]; other site 761659005870 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 761659005871 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659005872 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 761659005873 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 761659005874 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 761659005875 oligomerization interface [polypeptide binding]; other site 761659005876 active site 761659005877 metal binding site [ion binding]; metal-binding site 761659005878 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 761659005879 periplasmic chaperone; Provisional; Region: PRK10780 761659005880 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 761659005881 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659005882 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659005883 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659005884 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659005885 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659005886 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 761659005887 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 761659005888 catalytic residue [active] 761659005889 putative FPP diphosphate binding site; other site 761659005890 putative FPP binding hydrophobic cleft; other site 761659005891 dimer interface [polypeptide binding]; other site 761659005892 putative IPP diphosphate binding site; other site 761659005893 RIP metalloprotease RseP; Region: TIGR00054 761659005894 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 761659005895 active site 761659005896 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 761659005897 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 761659005898 protein binding site [polypeptide binding]; other site 761659005899 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 761659005900 putative substrate binding region [chemical binding]; other site 761659005901 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 761659005902 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 761659005903 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 761659005904 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 761659005905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005906 binding surface 761659005907 TPR motif; other site 761659005908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659005909 binding surface 761659005910 TPR motif; other site 761659005911 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005912 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 761659005913 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 761659005914 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 761659005915 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 761659005916 NADP binding site [chemical binding]; other site 761659005917 active site 761659005918 putative substrate binding site [chemical binding]; other site 761659005919 seryl-tRNA synthetase; Provisional; Region: PRK05431 761659005920 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 761659005921 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 761659005922 dimer interface [polypeptide binding]; other site 761659005923 active site 761659005924 motif 1; other site 761659005925 motif 2; other site 761659005926 motif 3; other site 761659005927 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 761659005928 AMP binding site [chemical binding]; other site 761659005929 metal binding site [ion binding]; metal-binding site 761659005930 active site 761659005931 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 761659005932 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 761659005933 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 761659005934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659005935 catalytic residue [active] 761659005936 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 761659005937 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 761659005938 hinge; other site 761659005939 active site 761659005940 Motility related/secretion protein; Region: SprA_N; pfam14349 761659005941 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 761659005942 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 761659005943 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 761659005944 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 761659005945 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 761659005946 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659005947 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 761659005948 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 761659005949 NodB motif; other site 761659005950 putative active site [active] 761659005951 putative catalytic site [active] 761659005952 putative Zn binding site [ion binding]; other site 761659005953 aconitate hydratase; Validated; Region: PRK09277 761659005954 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 761659005955 substrate binding site [chemical binding]; other site 761659005956 ligand binding site [chemical binding]; other site 761659005957 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 761659005958 substrate binding site [chemical binding]; other site 761659005959 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 761659005960 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 761659005961 DNA binding residues [nucleotide binding] 761659005962 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 761659005963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659005964 Walker A/P-loop; other site 761659005965 ATP binding site [chemical binding]; other site 761659005966 Q-loop/lid; other site 761659005967 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 761659005968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659005969 ABC transporter signature motif; other site 761659005970 Walker B; other site 761659005971 D-loop; other site 761659005972 H-loop/switch region; other site 761659005973 Yqey-like protein; Region: YqeY; pfam09424 761659005974 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 761659005975 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 761659005976 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 761659005977 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 761659005978 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 761659005979 dimerization domain swap beta strand [polypeptide binding]; other site 761659005980 regulatory protein interface [polypeptide binding]; other site 761659005981 active site 761659005982 regulatory phosphorylation site [posttranslational modification]; other site 761659005983 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 761659005984 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 761659005985 substrate binding pocket [chemical binding]; other site 761659005986 chain length determination region; other site 761659005987 substrate-Mg2+ binding site; other site 761659005988 catalytic residues [active] 761659005989 aspartate-rich region 1; other site 761659005990 active site lid residues [active] 761659005991 aspartate-rich region 2; other site 761659005992 adenylate kinase; Reviewed; Region: adk; PRK00279 761659005993 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 761659005994 AMP-binding site [chemical binding]; other site 761659005995 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 761659005996 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 761659005997 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 761659005998 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 761659005999 Methyltransferase domain; Region: Methyltransf_23; pfam13489 761659006000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659006001 S-adenosylmethionine binding site [chemical binding]; other site 761659006002 hypothetical protein; Provisional; Region: PRK08201 761659006003 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 761659006004 metal binding site [ion binding]; metal-binding site 761659006005 putative dimer interface [polypeptide binding]; other site 761659006006 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 761659006007 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 761659006008 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 761659006009 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 761659006010 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 761659006011 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006012 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 761659006013 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659006014 N-terminal plug; other site 761659006015 ligand-binding site [chemical binding]; other site 761659006016 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 761659006017 nudix motif; other site 761659006018 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 761659006019 nudix motif; other site 761659006020 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 761659006021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659006022 motif II; other site 761659006023 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 761659006024 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 761659006025 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 761659006026 Peptidase family M1; Region: Peptidase_M1; pfam01433 761659006027 Zn binding site [ion binding]; other site 761659006028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659006029 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 761659006030 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 761659006031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 761659006032 catalytic loop [active] 761659006033 iron binding site [ion binding]; other site 761659006034 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 761659006035 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 761659006036 active site 761659006037 metal binding site [ion binding]; metal-binding site 761659006038 nudix motif; other site 761659006039 Protein of unknown function, DUF547; Region: DUF547; pfam04784 761659006040 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 761659006041 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 761659006042 GatB domain; Region: GatB_Yqey; smart00845 761659006043 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 761659006044 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659006045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 761659006046 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 761659006047 triosephosphate isomerase; Provisional; Region: PRK14565 761659006048 substrate binding site [chemical binding]; other site 761659006049 dimer interface [polypeptide binding]; other site 761659006050 catalytic triad [active] 761659006051 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 761659006052 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 761659006053 putative active site; other site 761659006054 catalytic residue [active] 761659006055 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 761659006056 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 761659006057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659006058 Walker A motif; other site 761659006059 ATP binding site [chemical binding]; other site 761659006060 Walker B motif; other site 761659006061 arginine finger; other site 761659006062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659006063 active site 761659006064 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 761659006065 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 761659006066 active site 761659006067 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 761659006068 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659006069 active site 761659006070 Quinolinate synthetase A protein; Region: NadA; pfam02445 761659006071 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 761659006072 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 761659006073 dimerization interface [polypeptide binding]; other site 761659006074 active site 761659006075 L-aspartate oxidase; Provisional; Region: PRK08071 761659006076 L-aspartate oxidase; Provisional; Region: PRK06175 761659006077 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 761659006078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659006079 Interdomain contacts; other site 761659006080 Cytokine receptor motif; other site 761659006081 Calx-beta domain; Region: Calx-beta; cl02522 761659006082 Endonuclease I; Region: Endonuclease_1; cl01003 761659006083 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 761659006084 generic binding surface I; other site 761659006085 generic binding surface II; other site 761659006086 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659006087 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 761659006088 generic binding surface I; other site 761659006089 generic binding surface II; other site 761659006090 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006091 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659006092 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006093 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006094 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006095 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 761659006096 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659006097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659006098 Homeodomain-like domain; Region: HTH_23; pfam13384 761659006099 Sporulation related domain; Region: SPOR; cl10051 761659006100 Predicted amidohydrolase [General function prediction only]; Region: COG0388 761659006101 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 761659006102 active site 761659006103 catalytic triad [active] 761659006104 dimer interface [polypeptide binding]; other site 761659006105 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 761659006106 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 761659006107 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659006108 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 761659006109 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 761659006110 ligand binding site; other site 761659006111 oligomer interface; other site 761659006112 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 761659006113 dimer interface [polypeptide binding]; other site 761659006114 N-terminal domain interface [polypeptide binding]; other site 761659006115 sulfate 1 binding site; other site 761659006116 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 761659006117 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659006118 Protein of unknown function (DUF433); Region: DUF433; pfam04255 761659006119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 761659006120 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 761659006121 homodimer interface [polypeptide binding]; other site 761659006122 homotetramer interface [polypeptide binding]; other site 761659006123 active site pocket [active] 761659006124 cleavage site 761659006125 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 761659006126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659006127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659006128 DNA binding residues [nucleotide binding] 761659006129 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 761659006130 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659006131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 761659006132 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 761659006133 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 761659006134 active site 761659006135 metal binding site [ion binding]; metal-binding site 761659006136 homotetramer interface [polypeptide binding]; other site 761659006137 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 761659006138 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 761659006139 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 761659006140 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 761659006141 active site 761659006142 intersubunit interactions; other site 761659006143 catalytic residue [active] 761659006144 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 761659006145 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 761659006146 Beta-Casp domain; Region: Beta-Casp; smart01027 761659006147 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 761659006148 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 761659006149 FAD binding domain; Region: FAD_binding_4; pfam01565 761659006150 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 761659006151 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 761659006152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659006153 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 761659006154 protein binding site [polypeptide binding]; other site 761659006155 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 761659006156 Catalytic dyad [active] 761659006157 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 761659006158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659006159 S-adenosylmethionine binding site [chemical binding]; other site 761659006160 Uncharacterized conserved protein [Function unknown]; Region: COG1624 761659006161 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 761659006162 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 761659006163 dihydropteroate synthase; Region: DHPS; TIGR01496 761659006164 substrate binding pocket [chemical binding]; other site 761659006165 dimer interface [polypeptide binding]; other site 761659006166 inhibitor binding site; inhibition site 761659006167 GH3 auxin-responsive promoter; Region: GH3; pfam03321 761659006168 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 761659006169 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 761659006170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659006171 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 761659006172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659006173 DNA binding residues [nucleotide binding] 761659006174 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 761659006175 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 761659006176 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 761659006177 catalytic triad [active] 761659006178 Uncharacterized conserved protein [Function unknown]; Region: COG3595 761659006179 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 761659006180 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 761659006181 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 761659006182 Prephenate dehydratase; Region: PDT; pfam00800 761659006183 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 761659006184 putative L-Phe binding site [chemical binding]; other site 761659006185 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 761659006186 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 761659006187 putative dimer interface [polypeptide binding]; other site 761659006188 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659006189 putative catalytic site [active] 761659006190 putative metal binding site [ion binding]; other site 761659006191 putative phosphate binding site [ion binding]; other site 761659006192 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659006193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 761659006194 catalytic core [active] 761659006195 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659006196 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 761659006197 trimer interface [polypeptide binding]; other site 761659006198 active site 761659006199 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 761659006200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659006201 POT family; Region: PTR2; cl17359 761659006202 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 761659006203 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 761659006204 dimer interface [polypeptide binding]; other site 761659006205 anticodon binding site; other site 761659006206 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 761659006207 homodimer interface [polypeptide binding]; other site 761659006208 motif 1; other site 761659006209 active site 761659006210 motif 2; other site 761659006211 GAD domain; Region: GAD; pfam02938 761659006212 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 761659006213 motif 3; other site 761659006214 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 761659006215 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 761659006216 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 761659006217 tetramer interface [polypeptide binding]; other site 761659006218 TPP-binding site [chemical binding]; other site 761659006219 heterodimer interface [polypeptide binding]; other site 761659006220 phosphorylation loop region [posttranslational modification] 761659006221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 761659006222 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 761659006223 alpha subunit interface [polypeptide binding]; other site 761659006224 TPP binding site [chemical binding]; other site 761659006225 heterodimer interface [polypeptide binding]; other site 761659006226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 761659006227 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 761659006228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659006229 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 761659006230 putative active site [active] 761659006231 putative metal binding site [ion binding]; other site 761659006232 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 761659006233 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 761659006234 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 761659006235 E3 interaction surface; other site 761659006236 lipoyl attachment site [posttranslational modification]; other site 761659006237 e3 binding domain; Region: E3_binding; pfam02817 761659006238 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 761659006239 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 761659006240 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 761659006241 alpha subunit interface [polypeptide binding]; other site 761659006242 TPP binding site [chemical binding]; other site 761659006243 heterodimer interface [polypeptide binding]; other site 761659006244 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 761659006245 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 761659006246 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 761659006247 tetramer interface [polypeptide binding]; other site 761659006248 TPP-binding site [chemical binding]; other site 761659006249 heterodimer interface [polypeptide binding]; other site 761659006250 phosphorylation loop region [posttranslational modification] 761659006251 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 761659006252 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 761659006253 Ligand binding site; other site 761659006254 Putative Catalytic site; other site 761659006255 DXD motif; other site 761659006256 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 761659006257 isocitrate dehydrogenase; Validated; Region: PRK07362 761659006258 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 761659006259 putative active site [active] 761659006260 putative CoA binding site [chemical binding]; other site 761659006261 nudix motif; other site 761659006262 metal binding site [ion binding]; metal-binding site 761659006263 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 761659006264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659006265 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 761659006266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659006267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659006268 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 761659006269 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659006270 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 761659006271 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659006272 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 761659006273 Protein export membrane protein; Region: SecD_SecF; cl14618 761659006274 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 761659006275 Methyltransferase domain; Region: Methyltransf_25; pfam13649 761659006276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659006277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 761659006278 NAD(P) binding site [chemical binding]; other site 761659006279 active site 761659006280 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659006281 Ligand Binding Site [chemical binding]; other site 761659006282 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659006283 Ligand Binding Site [chemical binding]; other site 761659006284 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 761659006285 Peptidase S46; Region: Peptidase_S46; pfam10459 761659006286 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 761659006287 Peptidase S46; Region: Peptidase_S46; pfam10459 761659006288 PAS domain; Region: PAS_9; pfam13426 761659006289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006290 putative active site [active] 761659006291 heme pocket [chemical binding]; other site 761659006292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 761659006293 homodimer interface [polypeptide binding]; other site 761659006294 chemical substrate binding site [chemical binding]; other site 761659006295 oligomer interface [polypeptide binding]; other site 761659006296 metal binding site [ion binding]; metal-binding site 761659006297 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 761659006298 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 761659006299 active site 761659006300 catalytic site [active] 761659006301 substrate binding site [chemical binding]; other site 761659006302 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 761659006303 active site 761659006304 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 761659006305 protein-splicing catalytic site; other site 761659006306 thioester formation/cholesterol transfer; other site 761659006307 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 761659006308 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 761659006309 metal-binding site 761659006310 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 761659006311 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 761659006312 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 761659006313 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 761659006314 Na binding site [ion binding]; other site 761659006315 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 761659006316 dimer interface [polypeptide binding]; other site 761659006317 substrate binding site [chemical binding]; other site 761659006318 metal binding sites [ion binding]; metal-binding site 761659006319 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 761659006320 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 761659006321 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 761659006322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659006323 putative NAD(P) binding site [chemical binding]; other site 761659006324 Uncharacterized conserved protein [Function unknown]; Region: COG4748 761659006325 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 761659006326 Predicted esterase [General function prediction only]; Region: COG0627 761659006327 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 761659006328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659006329 AAA domain; Region: AAA_23; pfam13476 761659006330 Walker A/P-loop; other site 761659006331 ATP binding site [chemical binding]; other site 761659006332 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 761659006333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659006334 active site 761659006335 metal binding site [ion binding]; metal-binding site 761659006336 DNA binding site [nucleotide binding] 761659006337 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 761659006338 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659006339 GAF domain; Region: GAF; pfam01590 761659006340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006341 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659006342 putative active site [active] 761659006343 heme pocket [chemical binding]; other site 761659006344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006345 putative active site [active] 761659006346 heme pocket [chemical binding]; other site 761659006347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006348 putative active site [active] 761659006349 PAS fold; Region: PAS_3; pfam08447 761659006350 heme pocket [chemical binding]; other site 761659006351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006352 PAS fold; Region: PAS_3; pfam08447 761659006353 putative active site [active] 761659006354 heme pocket [chemical binding]; other site 761659006355 GAF domain; Region: GAF; pfam01590 761659006356 GAF domain; Region: GAF_2; pfam13185 761659006357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659006358 GAF domain; Region: GAF_3; pfam13492 761659006359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659006360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659006361 dimer interface [polypeptide binding]; other site 761659006362 phosphorylation site [posttranslational modification] 761659006363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659006364 ATP binding site [chemical binding]; other site 761659006365 Mg2+ binding site [ion binding]; other site 761659006366 G-X-G motif; other site 761659006367 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659006368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659006369 Homeodomain-like domain; Region: HTH_23; pfam13384 761659006370 Winged helix-turn helix; Region: HTH_29; pfam13551 761659006371 Homeodomain-like domain; Region: HTH_32; pfam13565 761659006372 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 761659006373 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 761659006374 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 761659006375 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 761659006376 dimer interface [polypeptide binding]; other site 761659006377 active site 761659006378 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 761659006379 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 761659006380 Class I aldolases; Region: Aldolase_Class_I; cl17187 761659006381 catalytic residue [active] 761659006382 Bacterial PH domain; Region: DUF304; pfam03703 761659006383 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 761659006384 dimer interface [polypeptide binding]; other site 761659006385 substrate binding site [chemical binding]; other site 761659006386 metal binding sites [ion binding]; metal-binding site 761659006387 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659006388 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 761659006389 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659006391 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659006392 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 761659006393 active site 761659006394 metal binding site [ion binding]; metal-binding site 761659006395 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 761659006396 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 761659006397 BNR repeat-like domain; Region: BNR_2; pfam13088 761659006398 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 761659006399 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 761659006400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 761659006401 ParA-like protein; Provisional; Region: PHA02518 761659006402 P-loop; other site 761659006403 Magnesium ion binding site [ion binding]; other site 761659006404 DoxX-like family; Region: DoxX_2; pfam13564 761659006405 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 761659006406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659006407 Fasciclin domain; Region: Fasciclin; pfam02469 761659006408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 761659006409 classical (c) SDRs; Region: SDR_c; cd05233 761659006410 NAD(P) binding site [chemical binding]; other site 761659006411 active site 761659006412 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 761659006413 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 761659006414 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 761659006415 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 761659006416 dimer interface [polypeptide binding]; other site 761659006417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659006418 catalytic residue [active] 761659006419 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 761659006420 MPN+ (JAMM) motif; other site 761659006421 Zinc-binding site [ion binding]; other site 761659006422 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 761659006423 MoaE interaction surface [polypeptide binding]; other site 761659006424 MoeB interaction surface [polypeptide binding]; other site 761659006425 thiocarboxylated glycine; other site 761659006426 hypothetical protein; Validated; Region: PRK07411 761659006427 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 761659006428 ATP binding site [chemical binding]; other site 761659006429 substrate interface [chemical binding]; other site 761659006430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 761659006431 active site residue [active] 761659006432 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 761659006433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 761659006434 active site 761659006435 HIGH motif; other site 761659006436 nucleotide binding site [chemical binding]; other site 761659006437 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 761659006438 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 761659006439 active site 761659006440 KMSKS motif; other site 761659006441 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 761659006442 tRNA binding surface [nucleotide binding]; other site 761659006443 anticodon binding site; other site 761659006444 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 761659006445 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 761659006446 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 761659006447 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 761659006448 FeoA domain; Region: FeoA; pfam04023 761659006449 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 761659006450 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 761659006451 Protein of unknown function (DUF971); Region: DUF971; pfam06155 761659006452 PAS domain; Region: PAS_9; pfam13426 761659006453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006454 putative active site [active] 761659006455 heme pocket [chemical binding]; other site 761659006456 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659006457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006458 putative active site [active] 761659006459 heme pocket [chemical binding]; other site 761659006460 PAS domain; Region: PAS_8; pfam13188 761659006461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006462 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 761659006463 putative active site [active] 761659006464 heme pocket [chemical binding]; other site 761659006465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659006466 dimer interface [polypeptide binding]; other site 761659006467 phosphorylation site [posttranslational modification] 761659006468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659006469 ATP binding site [chemical binding]; other site 761659006470 Mg2+ binding site [ion binding]; other site 761659006471 G-X-G motif; other site 761659006472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659006473 AAA domain; Region: AAA_21; pfam13304 761659006474 Walker A/P-loop; other site 761659006475 ATP binding site [chemical binding]; other site 761659006476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659006477 ABC transporter signature motif; other site 761659006478 Walker B; other site 761659006479 D-loop; other site 761659006480 H-loop/switch region; other site 761659006481 YceI-like domain; Region: YceI; pfam04264 761659006482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 761659006483 putative metal binding site [ion binding]; other site 761659006484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659006485 Fe2+ transport protein; Region: Iron_transport; pfam10634 761659006486 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 761659006487 Nitrogen regulatory protein P-II; Region: P-II; smart00938 761659006488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 761659006489 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 761659006490 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 761659006491 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 761659006492 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 761659006493 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 761659006494 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 761659006495 HSP70 interaction site [polypeptide binding]; other site 761659006496 phytoene desaturase; Region: crtI_fam; TIGR02734 761659006497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659006498 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659006499 PAS fold; Region: PAS_4; pfam08448 761659006500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 761659006501 PAS domain; Region: PAS_9; pfam13426 761659006502 putative active site [active] 761659006503 heme pocket [chemical binding]; other site 761659006504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006505 PAS domain; Region: PAS_9; pfam13426 761659006506 putative active site [active] 761659006507 heme pocket [chemical binding]; other site 761659006508 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 761659006509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659006510 putative active site [active] 761659006511 heme pocket [chemical binding]; other site 761659006512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 761659006513 dimer interface [polypeptide binding]; other site 761659006514 phosphorylation site [posttranslational modification] 761659006515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659006516 ATP binding site [chemical binding]; other site 761659006517 Mg2+ binding site [ion binding]; other site 761659006518 G-X-G motif; other site 761659006519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659006520 Response regulator receiver domain; Region: Response_reg; pfam00072 761659006521 active site 761659006522 phosphorylation site [posttranslational modification] 761659006523 intermolecular recognition site; other site 761659006524 dimerization interface [polypeptide binding]; other site 761659006525 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 761659006526 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 761659006527 Tetramer interface [polypeptide binding]; other site 761659006528 active site 761659006529 FMN-binding site [chemical binding]; other site 761659006530 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 761659006531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 761659006532 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 761659006533 protein binding site [polypeptide binding]; other site 761659006534 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 761659006535 protein binding site [polypeptide binding]; other site 761659006536 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 761659006537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659006538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659006539 dimer interface [polypeptide binding]; other site 761659006540 phosphorylation site [posttranslational modification] 761659006541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659006542 ATP binding site [chemical binding]; other site 761659006543 Mg2+ binding site [ion binding]; other site 761659006544 G-X-G motif; other site 761659006545 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 761659006546 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 761659006547 putative active site [active] 761659006548 Zn binding site [ion binding]; other site 761659006549 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 761659006550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659006551 S-adenosylmethionine binding site [chemical binding]; other site 761659006552 Acylphosphatase; Region: Acylphosphatase; pfam00708 761659006553 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 761659006554 cofactor binding site; other site 761659006555 metal binding site [ion binding]; metal-binding site 761659006556 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 761659006557 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659006558 putative catalytic residue [active] 761659006559 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 761659006560 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 761659006561 active site 761659006562 (T/H)XGH motif; other site 761659006563 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 761659006564 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 761659006565 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 761659006566 GMP synthase; Reviewed; Region: guaA; PRK00074 761659006567 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 761659006568 AMP/PPi binding site [chemical binding]; other site 761659006569 candidate oxyanion hole; other site 761659006570 catalytic triad [active] 761659006571 potential glutamine specificity residues [chemical binding]; other site 761659006572 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 761659006573 ATP Binding subdomain [chemical binding]; other site 761659006574 Ligand Binding sites [chemical binding]; other site 761659006575 Dimerization subdomain; other site 761659006576 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 761659006577 lipoyl attachment site [posttranslational modification]; other site 761659006578 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 761659006579 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 761659006580 active site 761659006581 (T/H)XGH motif; other site 761659006582 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 761659006583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659006584 S-adenosylmethionine binding site [chemical binding]; other site 761659006585 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus; Region: DGF-1_C; pfam11040 761659006586 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 761659006587 active site 761659006588 hydrophilic channel; other site 761659006589 dimerization interface [polypeptide binding]; other site 761659006590 catalytic residues [active] 761659006591 active site lid [active] 761659006592 GTPase Era; Reviewed; Region: era; PRK00089 761659006593 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 761659006594 G1 box; other site 761659006595 GTP/Mg2+ binding site [chemical binding]; other site 761659006596 Switch I region; other site 761659006597 G2 box; other site 761659006598 Switch II region; other site 761659006599 G3 box; other site 761659006600 G4 box; other site 761659006601 G5 box; other site 761659006602 KH domain; Region: KH_2; pfam07650 761659006603 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 761659006604 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 761659006605 ligand binding site [chemical binding]; other site 761659006606 NAD binding site [chemical binding]; other site 761659006607 catalytic site [active] 761659006608 homodimer interface [polypeptide binding]; other site 761659006609 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 761659006610 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659006611 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 761659006612 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 761659006613 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 761659006614 Predicted permeases [General function prediction only]; Region: COG0795 761659006615 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 761659006616 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 761659006617 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 761659006618 Predicted methyltransferases [General function prediction only]; Region: COG0313 761659006619 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 761659006620 putative SAM binding site [chemical binding]; other site 761659006621 putative homodimer interface [polypeptide binding]; other site 761659006622 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 761659006623 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659006624 catalytic residues [active] 761659006625 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 761659006626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 761659006627 DNA-binding site [nucleotide binding]; DNA binding site 761659006628 RNA-binding motif; other site 761659006629 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 761659006630 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 761659006631 30S subunit binding site; other site 761659006632 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 761659006633 FAD binding site [chemical binding]; other site 761659006634 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 761659006635 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 761659006636 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 761659006637 Subunit I/III interface [polypeptide binding]; other site 761659006638 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 761659006639 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 761659006640 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 761659006641 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 761659006642 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 761659006643 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 761659006644 Interdomain contacts; other site 761659006645 Cytokine receptor motif; other site 761659006646 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 761659006647 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 761659006648 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 761659006649 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 761659006650 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 761659006651 molybdopterin cofactor binding site; other site 761659006652 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 761659006653 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 761659006654 4Fe-4S binding domain; Region: Fer4; cl02805 761659006655 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 761659006656 heme-binding residues [chemical binding]; other site 761659006657 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006658 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659006659 N-terminal plug; other site 761659006660 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 761659006661 ligand-binding site [chemical binding]; other site 761659006662 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 761659006663 SelR domain; Region: SelR; pfam01641 761659006664 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 761659006665 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 761659006666 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 761659006667 active site 761659006668 ADP/pyrophosphate binding site [chemical binding]; other site 761659006669 dimerization interface [polypeptide binding]; other site 761659006670 allosteric effector site; other site 761659006671 fructose-1,6-bisphosphate binding site; other site 761659006672 Uncharacterized conserved protein [Function unknown]; Region: COG0327 761659006673 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 761659006674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 761659006675 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 761659006676 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 761659006677 Putative zinc ribbon domain; Region: DUF164; pfam02591 761659006678 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 761659006679 dimer interface [polypeptide binding]; other site 761659006680 ADP-ribose binding site [chemical binding]; other site 761659006681 active site 761659006682 nudix motif; other site 761659006683 metal binding site [ion binding]; metal-binding site 761659006684 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 761659006685 RNA methyltransferase, RsmE family; Region: TIGR00046 761659006686 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 761659006687 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659006688 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 761659006689 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 761659006690 minor groove reading motif; other site 761659006691 helix-hairpin-helix signature motif; other site 761659006692 substrate binding pocket [chemical binding]; other site 761659006693 active site 761659006694 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 761659006695 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 761659006696 active site 761659006697 8-oxo-dGMP binding site [chemical binding]; other site 761659006698 nudix motif; other site 761659006699 metal binding site [ion binding]; metal-binding site 761659006700 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 761659006701 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 761659006702 oligomerisation interface [polypeptide binding]; other site 761659006703 mobile loop; other site 761659006704 roof hairpin; other site 761659006705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 761659006706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 761659006707 ring oligomerisation interface [polypeptide binding]; other site 761659006708 ATP/Mg binding site [chemical binding]; other site 761659006709 stacking interactions; other site 761659006710 hinge regions; other site 761659006711 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 761659006712 CoA binding domain; Region: CoA_binding_2; pfam13380 761659006713 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 761659006714 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 761659006715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 761659006716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659006717 Coenzyme A binding pocket [chemical binding]; other site 761659006718 HerA helicase [Replication, recombination, and repair]; Region: COG0433 761659006719 Domain of unknown function DUF87; Region: DUF87; pfam01935 761659006720 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 761659006721 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659006722 FeS/SAM binding site; other site 761659006723 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 761659006724 histidinol dehydrogenase; Region: hisD; TIGR00069 761659006725 NAD binding site [chemical binding]; other site 761659006726 dimerization interface [polypeptide binding]; other site 761659006727 product binding site; other site 761659006728 substrate binding site [chemical binding]; other site 761659006729 zinc binding site [ion binding]; other site 761659006730 catalytic residues [active] 761659006731 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 761659006732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 761659006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659006734 homodimer interface [polypeptide binding]; other site 761659006735 catalytic residue [active] 761659006736 Bifunctional nuclease; Region: DNase-RNase; pfam02577 761659006737 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 761659006738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 761659006739 purine nucleoside phosphorylase; Provisional; Region: PRK08202 761659006740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 761659006741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 761659006742 RecX family; Region: RecX; cl00936 761659006743 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 761659006744 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659006745 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659006746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006747 FecR protein; Region: FecR; pfam04773 761659006748 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 761659006749 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 761659006750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659006751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659006752 DNA binding residues [nucleotide binding] 761659006753 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 761659006754 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 761659006755 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 761659006756 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 761659006757 hydrophobic ligand binding site; other site 761659006758 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 761659006759 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 761659006760 PYR/PP interface [polypeptide binding]; other site 761659006761 dimer interface [polypeptide binding]; other site 761659006762 TPP binding site [chemical binding]; other site 761659006763 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 761659006764 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 761659006765 TPP-binding site [chemical binding]; other site 761659006766 dimer interface [polypeptide binding]; other site 761659006767 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 761659006768 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 761659006769 putative valine binding site [chemical binding]; other site 761659006770 dimer interface [polypeptide binding]; other site 761659006771 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 761659006772 ketol-acid reductoisomerase; Provisional; Region: PRK05479 761659006773 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 761659006774 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 761659006775 tartrate dehydrogenase; Region: TTC; TIGR02089 761659006776 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 761659006777 2-isopropylmalate synthase; Validated; Region: PRK00915 761659006778 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 761659006779 active site 761659006780 catalytic residues [active] 761659006781 metal binding site [ion binding]; metal-binding site 761659006782 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 761659006783 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 761659006784 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 761659006785 substrate binding site [chemical binding]; other site 761659006786 ligand binding site [chemical binding]; other site 761659006787 four helix bundle protein; Region: TIGR02436 761659006788 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 761659006789 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 761659006790 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 761659006791 substrate binding site [chemical binding]; other site 761659006792 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 761659006793 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 761659006794 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 761659006795 active site 761659006796 catalytic residues [active] 761659006797 metal binding site [ion binding]; metal-binding site 761659006798 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 761659006799 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 761659006800 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 761659006801 catalytic residues [active] 761659006802 Tetratricopeptide repeat; Region: TPR_16; pfam13432 761659006803 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 761659006804 active site 761659006805 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 761659006806 Phosphotransferase enzyme family; Region: APH; pfam01636 761659006807 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 761659006808 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 761659006809 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006810 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659006811 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006812 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 761659006813 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 761659006814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659006815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 761659006816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659006817 Walker A/P-loop; other site 761659006818 ATP binding site [chemical binding]; other site 761659006819 Q-loop/lid; other site 761659006820 ABC transporter signature motif; other site 761659006821 Walker B; other site 761659006822 D-loop; other site 761659006823 H-loop/switch region; other site 761659006824 ribonuclease Z; Region: RNase_Z; TIGR02651 761659006825 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659006826 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 761659006827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659006828 Walker A/P-loop; other site 761659006829 ATP binding site [chemical binding]; other site 761659006830 Q-loop/lid; other site 761659006831 ABC transporter signature motif; other site 761659006832 Walker B; other site 761659006833 D-loop; other site 761659006834 H-loop/switch region; other site 761659006835 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 761659006836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 761659006837 ligand binding site [chemical binding]; other site 761659006838 flexible hinge region; other site 761659006839 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659006840 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 761659006841 Peptidase family M23; Region: Peptidase_M23; pfam01551 761659006842 HPr kinase/phosphorylase; Provisional; Region: PRK05428 761659006843 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 761659006844 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 761659006845 Hpr binding site; other site 761659006846 active site 761659006847 homohexamer subunit interaction site [polypeptide binding]; other site 761659006848 MoxR-like ATPases [General function prediction only]; Region: COG0714 761659006849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659006850 Walker A motif; other site 761659006851 ATP binding site [chemical binding]; other site 761659006852 Walker B motif; other site 761659006853 arginine finger; other site 761659006854 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 761659006855 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 761659006856 putative active site [active] 761659006857 substrate binding site [chemical binding]; other site 761659006858 putative cosubstrate binding site; other site 761659006859 catalytic site [active] 761659006860 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 761659006861 substrate binding site [chemical binding]; other site 761659006862 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 761659006863 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 761659006864 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 761659006865 P loop; other site 761659006866 GTP binding site [chemical binding]; other site 761659006867 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 761659006868 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 761659006869 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659006870 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006871 Fasciclin domain; Region: Fasciclin; pfam02469 761659006872 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 761659006873 starch binding outer membrane protein SusD; Region: SusD; cl17845 761659006874 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659006875 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659006876 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 761659006877 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659006878 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 761659006879 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 761659006880 DNA binding site [nucleotide binding] 761659006881 active site 761659006882 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 761659006883 starch binding outer membrane protein SusD; Region: SusD; cd08977 761659006884 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659006885 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659006886 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659006887 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 761659006888 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 761659006889 DNA binding site [nucleotide binding] 761659006890 active site 761659006891 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 761659006892 FAD binding domain; Region: FAD_binding_4; pfam01565 761659006893 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 761659006894 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659006895 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 761659006896 CcmB protein; Region: CcmB; cl17444 761659006897 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 761659006898 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 761659006899 CcmE; Region: CcmE; cl00994 761659006900 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 761659006901 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 761659006902 MgtE intracellular N domain; Region: MgtE_N; pfam03448 761659006903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 761659006904 Divalent cation transporter; Region: MgtE; pfam01769 761659006905 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 761659006906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659006907 S-adenosylmethionine binding site [chemical binding]; other site 761659006908 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 761659006909 metal ion-dependent adhesion site (MIDAS); other site 761659006910 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 761659006911 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 761659006912 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 761659006913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 761659006914 dihydroorotase; Validated; Region: pyrC; PRK09357 761659006915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659006916 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 761659006917 active site 761659006918 DNA gyrase subunit A; Validated; Region: PRK05560 761659006919 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 761659006920 CAP-like domain; other site 761659006921 active site 761659006922 primary dimer interface [polypeptide binding]; other site 761659006923 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659006924 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659006925 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659006926 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659006927 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 761659006928 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 761659006929 putative active site [active] 761659006930 putative catalytic triad [active] 761659006931 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 761659006932 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659006933 Interdomain contacts; other site 761659006934 Cytokine receptor motif; other site 761659006935 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659006936 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 761659006937 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 761659006938 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 761659006939 active site 761659006940 substrate binding site [chemical binding]; other site 761659006941 metal binding site [ion binding]; metal-binding site 761659006942 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659006943 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 761659006944 Walker A/P-loop; other site 761659006945 ATP binding site [chemical binding]; other site 761659006946 Q-loop/lid; other site 761659006947 ABC transporter signature motif; other site 761659006948 Walker B; other site 761659006949 D-loop; other site 761659006950 H-loop/switch region; other site 761659006951 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 761659006952 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 761659006953 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 761659006954 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 761659006955 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 761659006956 ligand binding site [chemical binding]; other site 761659006957 homodimer interface [polypeptide binding]; other site 761659006958 NAD(P) binding site [chemical binding]; other site 761659006959 trimer interface B [polypeptide binding]; other site 761659006960 trimer interface A [polypeptide binding]; other site 761659006961 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 761659006962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659006963 catalytic residue [active] 761659006964 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 761659006965 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 761659006966 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 761659006967 Fasciclin domain; Region: Fasciclin; pfam02469 761659006968 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 761659006969 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 761659006970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659006971 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 761659006972 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 761659006973 putative active site [active] 761659006974 argininosuccinate synthase; Provisional; Region: PRK13820 761659006975 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 761659006976 Ligand Binding Site [chemical binding]; other site 761659006977 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 761659006978 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 761659006979 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 761659006980 inhibitor-cofactor binding pocket; inhibition site 761659006981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659006982 catalytic residue [active] 761659006983 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 761659006984 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 761659006985 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 761659006986 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 761659006987 nucleotide binding site [chemical binding]; other site 761659006988 N-acetyl-L-glutamate binding site [chemical binding]; other site 761659006989 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 761659006990 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 761659006991 metal binding site [ion binding]; metal-binding site 761659006992 argininosuccinate lyase; Provisional; Region: PRK00855 761659006993 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 761659006994 active sites [active] 761659006995 tetramer interface [polypeptide binding]; other site 761659006996 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 761659006997 photoactive yellow protein; Region: photo_yellow; TIGR02373 761659006998 PAS domain; Region: PAS_9; pfam13426 761659006999 Uncharacterized conserved protein [Function unknown]; Region: COG1615 761659007000 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 761659007001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 761659007002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007003 S-adenosylmethionine binding site [chemical binding]; other site 761659007004 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 761659007005 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 761659007006 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 761659007007 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 761659007008 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 761659007009 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 761659007010 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 761659007011 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 761659007012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659007013 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 761659007014 DHH family; Region: DHH; pfam01368 761659007015 DHHA1 domain; Region: DHHA1; pfam02272 761659007016 transcription termination factor Rho; Provisional; Region: rho; PRK09376 761659007017 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 761659007018 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 761659007019 RNA binding site [nucleotide binding]; other site 761659007020 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 761659007021 multimer interface [polypeptide binding]; other site 761659007022 Walker A motif; other site 761659007023 ATP binding site [chemical binding]; other site 761659007024 Walker B motif; other site 761659007025 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 761659007026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659007027 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659007028 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 761659007029 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 761659007030 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 761659007031 protein binding site [polypeptide binding]; other site 761659007032 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 761659007033 Domain interface; other site 761659007034 Peptide binding site; other site 761659007035 Active site tetrad [active] 761659007036 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 761659007037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659007038 active site 761659007039 motif I; other site 761659007040 motif II; other site 761659007041 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 761659007042 ligand binding site [chemical binding]; other site 761659007043 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 761659007044 active site 761659007045 Ap6A binding site [chemical binding]; other site 761659007046 nudix motif; other site 761659007047 metal binding site [ion binding]; metal-binding site 761659007048 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 761659007049 high affinity sulphate transporter 1; Region: sulP; TIGR00815 761659007050 Sulfate transporter family; Region: Sulfate_transp; pfam00916 761659007051 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 761659007052 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 761659007053 DinB superfamily; Region: DinB_2; pfam12867 761659007054 DinB family; Region: DinB; cl17821 761659007055 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 761659007056 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 761659007057 putative active site [active] 761659007058 Zn binding site [ion binding]; other site 761659007059 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 761659007060 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 761659007061 AsnC family; Region: AsnC_trans_reg; pfam01037 761659007062 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 761659007063 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 761659007064 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 761659007065 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 761659007066 Fasciclin domain; Region: Fasciclin; pfam02469 761659007067 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 761659007068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659007069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659007070 DNA binding residues [nucleotide binding] 761659007071 FecR protein; Region: FecR; pfam04773 761659007072 Secretin and TonB N terminus short domain; Region: STN; smart00965 761659007073 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659007074 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 761659007075 glutamate dehydrogenase; Region: PLN02477 761659007076 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 761659007077 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 761659007078 NAD(P) binding site [chemical binding]; other site 761659007079 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 761659007080 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 761659007081 TrkA-N domain; Region: TrkA_N; pfam02254 761659007082 K-Cl cotransporter; Region: 2a30; TIGR00930 761659007083 amino acid transporter; Region: 2A0306; TIGR00909 761659007084 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 761659007085 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 761659007086 Ligand Binding Site [chemical binding]; other site 761659007087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659007088 Ligand Binding Site [chemical binding]; other site 761659007089 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 761659007090 amino acid transporter; Region: 2A0306; TIGR00909 761659007091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 761659007092 Ligand Binding Site [chemical binding]; other site 761659007093 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659007094 TrkA-N domain; Region: TrkA_N; pfam02254 761659007095 TrkA-C domain; Region: TrkA_C; pfam02080 761659007096 amino acid transporter; Region: 2A0306; TIGR00909 761659007097 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 761659007098 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 761659007099 TrkA-N domain; Region: TrkA_N; pfam02254 761659007100 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659007101 TrkA-C domain; Region: TrkA_C; pfam02080 761659007102 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659007103 TrkA-N domain; Region: TrkA_N; pfam02254 761659007104 TrkA-C domain; Region: TrkA_C; pfam02080 761659007105 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659007106 TrkA-N domain; Region: TrkA_N; pfam02254 761659007107 TrkA-C domain; Region: TrkA_C; pfam02080 761659007108 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 761659007109 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 761659007110 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 761659007111 TrkA-N domain; Region: TrkA_N; pfam02254 761659007112 TrkA-C domain; Region: TrkA_C; pfam02080 761659007113 TrkA-N domain; Region: TrkA_N; pfam02254 761659007114 TrkA-C domain; Region: TrkA_C; pfam02080 761659007115 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 761659007116 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 761659007117 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 761659007118 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 761659007119 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 761659007120 TrkA-N domain; Region: TrkA_N; pfam02254 761659007121 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 761659007122 TrkA-N domain; Region: TrkA_N; pfam02254 761659007123 amino acid transporter; Region: 2A0306; TIGR00909 761659007124 amino acid transporter; Region: 2A0306; TIGR00909 761659007125 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 761659007126 active site 761659007127 phosphorylation site [posttranslational modification] 761659007128 TrkA-C domain; Region: TrkA_C; pfam02080 761659007129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007130 PAS domain; Region: PAS_9; pfam13426 761659007131 putative active site [active] 761659007132 heme pocket [chemical binding]; other site 761659007133 PAS domain; Region: PAS_9; pfam13426 761659007134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007135 putative active site [active] 761659007136 heme pocket [chemical binding]; other site 761659007137 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659007138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007139 putative active site [active] 761659007140 heme pocket [chemical binding]; other site 761659007141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659007142 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 761659007143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007145 dimer interface [polypeptide binding]; other site 761659007146 phosphorylation site [posttranslational modification] 761659007147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007148 ATP binding site [chemical binding]; other site 761659007149 Mg2+ binding site [ion binding]; other site 761659007150 G-X-G motif; other site 761659007151 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 761659007152 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 761659007153 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 761659007154 shikimate binding site; other site 761659007155 NAD(P) binding site [chemical binding]; other site 761659007156 OsmC-like protein; Region: OsmC; pfam02566 761659007157 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 761659007158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659007159 NAD(P) binding site [chemical binding]; other site 761659007160 active site 761659007161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 761659007162 FOG: CBS domain [General function prediction only]; Region: COG0517 761659007163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659007164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 761659007165 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 761659007166 Walker A/P-loop; other site 761659007167 ATP binding site [chemical binding]; other site 761659007168 Q-loop/lid; other site 761659007169 ABC transporter signature motif; other site 761659007170 Walker B; other site 761659007171 D-loop; other site 761659007172 H-loop/switch region; other site 761659007173 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 761659007174 putative FMN binding site [chemical binding]; other site 761659007175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659007176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659007177 threonine dehydratase; Provisional; Region: PRK08198 761659007178 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 761659007179 tetramer interface [polypeptide binding]; other site 761659007180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659007181 catalytic residue [active] 761659007182 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 761659007183 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 761659007184 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 761659007185 active site 761659007186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659007187 ATP binding site [chemical binding]; other site 761659007188 putative Mg++ binding site [ion binding]; other site 761659007189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659007190 nucleotide binding region [chemical binding]; other site 761659007191 ATP-binding site [chemical binding]; other site 761659007192 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 761659007193 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 761659007194 putative efflux protein, MATE family; Region: matE; TIGR00797 761659007195 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659007196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007197 active site 761659007198 phosphorylation site [posttranslational modification] 761659007199 intermolecular recognition site; other site 761659007200 dimerization interface [polypeptide binding]; other site 761659007201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659007202 DNA binding site [nucleotide binding] 761659007203 PBP superfamily domain; Region: PBP_like_2; cl17296 761659007204 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 761659007205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659007206 dimer interface [polypeptide binding]; other site 761659007207 conserved gate region; other site 761659007208 putative PBP binding loops; other site 761659007209 ABC-ATPase subunit interface; other site 761659007210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 761659007211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659007212 dimer interface [polypeptide binding]; other site 761659007213 conserved gate region; other site 761659007214 putative PBP binding loops; other site 761659007215 ABC-ATPase subunit interface; other site 761659007216 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 761659007217 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 761659007218 Walker A/P-loop; other site 761659007219 ATP binding site [chemical binding]; other site 761659007220 Q-loop/lid; other site 761659007221 ABC transporter signature motif; other site 761659007222 Walker B; other site 761659007223 D-loop; other site 761659007224 H-loop/switch region; other site 761659007225 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 761659007226 PhoU domain; Region: PhoU; pfam01895 761659007227 PhoU domain; Region: PhoU; pfam01895 761659007228 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 761659007229 dockerin binding interface; other site 761659007230 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659007231 Peptidase S8 family domain in Fervidolysin; Region: Peptidases_S8_Fervidolysin_like; cd07485 761659007232 active site 761659007233 catalytic triad [active] 761659007234 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 761659007235 Interdomain contacts; other site 761659007236 Cytokine receptor motif; other site 761659007237 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659007238 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 761659007239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 761659007240 putative acyl-acceptor binding pocket; other site 761659007241 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 761659007242 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 761659007243 catalytic motif [active] 761659007244 Zn binding site [ion binding]; other site 761659007245 RibD C-terminal domain; Region: RibD_C; cl17279 761659007246 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 761659007247 Lumazine binding domain; Region: Lum_binding; pfam00677 761659007248 Lumazine binding domain; Region: Lum_binding; pfam00677 761659007249 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 761659007250 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 761659007251 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 761659007252 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 761659007253 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 761659007254 putative NAD(P) binding site [chemical binding]; other site 761659007255 putative substrate binding site [chemical binding]; other site 761659007256 catalytic Zn binding site [ion binding]; other site 761659007257 structural Zn binding site [ion binding]; other site 761659007258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659007259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 761659007260 putative substrate translocation pore; other site 761659007261 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 761659007262 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 761659007263 active site 761659007264 catalytic site [active] 761659007265 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 761659007266 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 761659007267 putative NAD(P) binding site [chemical binding]; other site 761659007268 homodimer interface [polypeptide binding]; other site 761659007269 Amino acid permease; Region: AA_permease_2; pfam13520 761659007270 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659007271 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659007272 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659007273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659007274 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 761659007275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007276 S-adenosylmethionine binding site [chemical binding]; other site 761659007277 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 761659007278 Part of AAA domain; Region: AAA_19; pfam13245 761659007279 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 761659007280 active site 761659007281 catalytic site [active] 761659007282 substrate binding site [chemical binding]; other site 761659007283 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 761659007284 Family description; Region: UvrD_C_2; pfam13538 761659007285 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 761659007286 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 761659007287 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 761659007288 homodimer interface [polypeptide binding]; other site 761659007289 substrate-cofactor binding pocket; other site 761659007290 catalytic residue [active] 761659007291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659007292 Coenzyme A binding pocket [chemical binding]; other site 761659007293 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 761659007294 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 761659007295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007297 dimer interface [polypeptide binding]; other site 761659007298 phosphorylation site [posttranslational modification] 761659007299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007300 ATP binding site [chemical binding]; other site 761659007301 Mg2+ binding site [ion binding]; other site 761659007302 G-X-G motif; other site 761659007303 Response regulator receiver domain; Region: Response_reg; pfam00072 761659007304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007305 active site 761659007306 phosphorylation site [posttranslational modification] 761659007307 intermolecular recognition site; other site 761659007308 dimerization interface [polypeptide binding]; other site 761659007309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 761659007310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 761659007311 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659007312 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659007313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659007314 Histidine kinase; Region: His_kinase; pfam06580 761659007315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007316 ATP binding site [chemical binding]; other site 761659007317 Mg2+ binding site [ion binding]; other site 761659007318 G-X-G motif; other site 761659007319 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659007320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007321 active site 761659007322 phosphorylation site [posttranslational modification] 761659007323 intermolecular recognition site; other site 761659007324 dimerization interface [polypeptide binding]; other site 761659007325 LytTr DNA-binding domain; Region: LytTR; smart00850 761659007326 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 761659007327 active site 761659007328 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 761659007329 dimer interface [polypeptide binding]; other site 761659007330 non-prolyl cis peptide bond; other site 761659007331 insertion regions; other site 761659007332 ATP-grasp domain; Region: ATP-grasp_4; cl17255 761659007333 DNA photolyase; Region: DNA_photolyase; pfam00875 761659007334 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 761659007335 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 761659007336 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 761659007337 putative dimer interface [polypeptide binding]; other site 761659007338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007339 S-adenosylmethionine binding site [chemical binding]; other site 761659007340 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 761659007341 CoA-transferase family III; Region: CoA_transf_3; pfam02515 761659007342 glycyl-tRNA synthetase; Provisional; Region: PRK04173 761659007343 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 761659007344 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 761659007345 motif 1; other site 761659007346 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 761659007347 active site 761659007348 motif 2; other site 761659007349 motif 3; other site 761659007350 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 761659007351 anticodon binding site; other site 761659007352 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 761659007353 four helix bundle protein; Region: TIGR02436 761659007354 hypothetical protein; Reviewed; Region: PRK00024 761659007355 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 761659007356 MPN+ (JAMM) motif; other site 761659007357 Zinc-binding site [ion binding]; other site 761659007358 transcription termination factor Rho; Provisional; Region: PRK12608 761659007359 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 761659007360 RNA binding site [nucleotide binding]; other site 761659007361 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 761659007362 Walker A motif; other site 761659007363 ATP binding site [chemical binding]; other site 761659007364 Walker B motif; other site 761659007365 PGAP1-like protein; Region: PGAP1; pfam07819 761659007366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 761659007367 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 761659007368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659007369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 761659007370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659007371 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 761659007372 putative metal binding site [ion binding]; other site 761659007373 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 761659007374 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 761659007375 active site 761659007376 Zn binding site [ion binding]; other site 761659007377 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 761659007378 reactive center loop; other site 761659007379 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 761659007380 active site 761659007381 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 761659007382 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 761659007383 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 761659007384 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 761659007385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 761659007386 HSP70 interaction site [polypeptide binding]; other site 761659007387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 761659007388 substrate binding site [polypeptide binding]; other site 761659007389 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 761659007390 Zn binding sites [ion binding]; other site 761659007391 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 761659007392 dimer interface [polypeptide binding]; other site 761659007393 GrpE; Region: GrpE; pfam01025 761659007394 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 761659007395 dimer interface [polypeptide binding]; other site 761659007396 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 761659007397 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 761659007398 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 761659007399 tandem repeat interface [polypeptide binding]; other site 761659007400 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 761659007401 oligomer interface [polypeptide binding]; other site 761659007402 active site residues [active] 761659007403 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 761659007404 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 761659007405 tandem repeat interface [polypeptide binding]; other site 761659007406 oligomer interface [polypeptide binding]; other site 761659007407 active site residues [active] 761659007408 phosphoglyceromutase; Provisional; Region: PRK05434 761659007409 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 761659007410 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 761659007411 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 761659007412 minor groove reading motif; other site 761659007413 helix-hairpin-helix signature motif; other site 761659007414 substrate binding pocket [chemical binding]; other site 761659007415 active site 761659007416 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 761659007417 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 761659007418 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 761659007419 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 761659007420 putative dimer interface [polypeptide binding]; other site 761659007421 fumarylacetoacetase; Region: PLN02856 761659007422 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 761659007423 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 761659007424 TPR repeat; Region: TPR_11; pfam13414 761659007425 TPR repeat; Region: TPR_11; pfam13414 761659007426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659007427 binding surface 761659007428 TPR motif; other site 761659007429 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 761659007430 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 761659007431 homodimer interface [polypeptide binding]; other site 761659007432 substrate-cofactor binding pocket; other site 761659007433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659007434 catalytic residue [active] 761659007435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 761659007436 AMP-binding enzyme; Region: AMP-binding; pfam00501 761659007437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 761659007438 active site 761659007439 AMP binding site [chemical binding]; other site 761659007440 acyl-activating enzyme (AAE) consensus motif; other site 761659007441 CoA binding site [chemical binding]; other site 761659007442 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 761659007443 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 761659007444 active site 761659007445 substrate binding site [chemical binding]; other site 761659007446 metal binding site [ion binding]; metal-binding site 761659007447 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 761659007448 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 761659007449 UbiA prenyltransferase family; Region: UbiA; pfam01040 761659007450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 761659007451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007452 Walker A/P-loop; other site 761659007453 ATP binding site [chemical binding]; other site 761659007454 Q-loop/lid; other site 761659007455 ABC transporter signature motif; other site 761659007456 Walker B; other site 761659007457 D-loop; other site 761659007458 H-loop/switch region; other site 761659007459 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 761659007460 ABC-2 type transporter; Region: ABC2_membrane; cl17235 761659007461 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 761659007462 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 761659007463 RNA/DNA hybrid binding site [nucleotide binding]; other site 761659007464 active site 761659007465 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 761659007466 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 761659007467 active site 761659007468 substrate-binding site [chemical binding]; other site 761659007469 metal-binding site [ion binding] 761659007470 ATP binding site [chemical binding]; other site 761659007471 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 761659007472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659007473 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 761659007474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659007475 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 761659007476 active site 761659007477 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 761659007478 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 761659007479 Predicted membrane protein [Function unknown]; Region: COG3650 761659007480 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 761659007481 threonine synthase; Validated; Region: PRK09225 761659007482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 761659007483 catalytic residue [active] 761659007484 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 761659007485 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 761659007486 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 761659007487 acyl-activating enzyme (AAE) consensus motif; other site 761659007488 putative AMP binding site [chemical binding]; other site 761659007489 putative active site [active] 761659007490 putative CoA binding site [chemical binding]; other site 761659007491 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 761659007492 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 761659007493 quinone interaction residues [chemical binding]; other site 761659007494 active site 761659007495 catalytic residues [active] 761659007496 FMN binding site [chemical binding]; other site 761659007497 substrate binding site [chemical binding]; other site 761659007498 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 761659007499 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 761659007500 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 761659007501 structural tetrad; other site 761659007502 Surface antigen; Region: Bac_surface_Ag; pfam01103 761659007503 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 761659007504 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 761659007505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 761659007506 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 761659007507 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 761659007508 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 761659007509 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 761659007510 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 761659007511 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 761659007512 hypothetical protein; Provisional; Region: PRK11770 761659007513 Domain of unknown function (DUF307); Region: DUF307; pfam03733 761659007514 Domain of unknown function (DUF307); Region: DUF307; pfam03733 761659007515 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 761659007516 GIY-YIG motif/motif A; other site 761659007517 putative active site [active] 761659007518 putative metal binding site [ion binding]; other site 761659007519 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 761659007520 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 761659007521 mercuric reductase; Validated; Region: PRK06370 761659007522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659007523 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 761659007524 PAS domain S-box; Region: sensory_box; TIGR00229 761659007525 PAS domain; Region: PAS; smart00091 761659007526 putative active site [active] 761659007527 heme pocket [chemical binding]; other site 761659007528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007529 dimer interface [polypeptide binding]; other site 761659007530 phosphorylation site [posttranslational modification] 761659007531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007533 ATP binding site [chemical binding]; other site 761659007534 Mg2+ binding site [ion binding]; other site 761659007535 G-X-G motif; other site 761659007536 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 761659007537 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 761659007538 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 761659007539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007540 Walker A/P-loop; other site 761659007541 ATP binding site [chemical binding]; other site 761659007542 Q-loop/lid; other site 761659007543 ABC transporter signature motif; other site 761659007544 Walker B; other site 761659007545 D-loop; other site 761659007546 H-loop/switch region; other site 761659007547 TOBE domain; Region: TOBE_2; pfam08402 761659007548 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 761659007549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659007550 dimer interface [polypeptide binding]; other site 761659007551 conserved gate region; other site 761659007552 putative PBP binding loops; other site 761659007553 ABC-ATPase subunit interface; other site 761659007554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659007555 dimer interface [polypeptide binding]; other site 761659007556 conserved gate region; other site 761659007557 putative PBP binding loops; other site 761659007558 ABC-ATPase subunit interface; other site 761659007559 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 761659007560 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 761659007561 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 761659007562 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 761659007563 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659007564 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 761659007565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659007566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 761659007567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 761659007568 active site 761659007569 catalytic tetrad [active] 761659007570 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 761659007571 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 761659007572 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 761659007573 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 761659007574 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 761659007575 heme binding site [chemical binding]; other site 761659007576 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 761659007577 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 761659007578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 761659007579 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 761659007580 dimerization interface [polypeptide binding]; other site 761659007581 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 761659007582 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 761659007583 Ligand binding site; other site 761659007584 Putative Catalytic site; other site 761659007585 DXD motif; other site 761659007586 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 761659007587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007588 Mg2+ binding site [ion binding]; other site 761659007589 G-X-G motif; other site 761659007590 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 761659007591 anchoring element; other site 761659007592 dimer interface [polypeptide binding]; other site 761659007593 ATP binding site [chemical binding]; other site 761659007594 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 761659007595 active site 761659007596 putative metal-binding site [ion binding]; other site 761659007597 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 761659007598 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 761659007599 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 761659007600 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 761659007601 Ca binding site [ion binding]; other site 761659007602 active site 761659007603 homodimer interface [polypeptide binding]; other site 761659007604 catalytic site [active] 761659007605 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 761659007606 FOG: CBS domain [General function prediction only]; Region: COG0517 761659007607 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 761659007608 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 761659007609 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 761659007610 HflX GTPase family; Region: HflX; cd01878 761659007611 G1 box; other site 761659007612 GTP/Mg2+ binding site [chemical binding]; other site 761659007613 Switch I region; other site 761659007614 G2 box; other site 761659007615 G3 box; other site 761659007616 Switch II region; other site 761659007617 G4 box; other site 761659007618 G5 box; other site 761659007619 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 761659007620 CARDB; Region: CARDB; pfam07705 761659007621 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 761659007622 conserved cys residue [active] 761659007623 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 761659007624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007625 S-adenosylmethionine binding site [chemical binding]; other site 761659007626 Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324 761659007627 Response regulator receiver domain; Region: Response_reg; pfam00072 761659007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007629 active site 761659007630 phosphorylation site [posttranslational modification] 761659007631 intermolecular recognition site; other site 761659007632 dimerization interface [polypeptide binding]; other site 761659007633 PglZ domain; Region: PglZ; pfam08665 761659007634 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 761659007635 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 761659007636 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 761659007637 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 761659007638 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 761659007639 DTAP/Switch II; other site 761659007640 Switch I; other site 761659007641 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 761659007642 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 761659007643 tetramerization interface [polypeptide binding]; other site 761659007644 substrate binding pocket [chemical binding]; other site 761659007645 catalytic residues [active] 761659007646 inhibitor binding sites; inhibition site 761659007647 NADP(H) binding site [chemical binding]; other site 761659007648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659007649 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 761659007650 active site 761659007651 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 761659007652 thiamine monophosphate kinase; Provisional; Region: PRK05731 761659007653 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 761659007654 ATP binding site [chemical binding]; other site 761659007655 dimerization interface [polypeptide binding]; other site 761659007656 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 761659007657 putative binding surface; other site 761659007658 active site 761659007659 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 761659007660 active site 761659007661 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 761659007662 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 761659007663 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 761659007664 alpha subunit interaction interface [polypeptide binding]; other site 761659007665 Walker A motif; other site 761659007666 ATP binding site [chemical binding]; other site 761659007667 Walker B motif; other site 761659007668 inhibitor binding site; inhibition site 761659007669 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 761659007670 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 761659007671 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 761659007672 gamma subunit interface [polypeptide binding]; other site 761659007673 epsilon subunit interface [polypeptide binding]; other site 761659007674 LBP interface [polypeptide binding]; other site 761659007675 HEAT repeats; Region: HEAT_2; pfam13646 761659007676 HEAT repeats; Region: HEAT_2; pfam13646 761659007677 HEAT repeats; Region: HEAT_2; pfam13646 761659007678 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 761659007679 active site 761659007680 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 761659007681 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 761659007682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 761659007683 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 761659007684 catalytic residue [active] 761659007685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 761659007686 nucleotide binding site [chemical binding]; other site 761659007687 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 761659007688 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 761659007689 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 761659007690 active site 761659007691 NTP binding site [chemical binding]; other site 761659007692 metal binding triad [ion binding]; metal-binding site 761659007693 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 761659007694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 761659007695 Zn2+ binding site [ion binding]; other site 761659007696 Mg2+ binding site [ion binding]; other site 761659007697 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 761659007698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007699 S-adenosylmethionine binding site [chemical binding]; other site 761659007700 Sulfatase; Region: Sulfatase; cl17466 761659007701 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 761659007702 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 761659007703 FOG: CBS domain [General function prediction only]; Region: COG0517 761659007704 oxidoreductase; Provisional; Region: PRK06196 761659007705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659007706 NAD(P) binding site [chemical binding]; other site 761659007707 active site 761659007708 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 761659007709 L-aspartate oxidase; Provisional; Region: PRK06175 761659007710 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 761659007711 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 761659007712 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 761659007713 putative active site [active] 761659007714 putative metal binding site [ion binding]; other site 761659007715 PhoD-like phosphatase; Region: PhoD; pfam09423 761659007716 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 761659007717 putative active site [active] 761659007718 putative metal binding site [ion binding]; other site 761659007719 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 761659007720 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659007721 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659007722 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659007723 C factor cell-cell signaling protein; Provisional; Region: PRK09009 761659007724 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 761659007725 NADP binding site [chemical binding]; other site 761659007726 homodimer interface [polypeptide binding]; other site 761659007727 active site 761659007728 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 761659007729 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659007730 catalytic residues [active] 761659007731 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659007732 Amidohydrolase; Region: Amidohydro_4; pfam13147 761659007733 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659007734 active site 761659007735 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 761659007736 DNA-binding site [nucleotide binding]; DNA binding site 761659007737 RNA-binding motif; other site 761659007738 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 761659007739 Alkaline phosphatase homologues; Region: alkPPc; smart00098 761659007740 active site 761659007741 dimer interface [polypeptide binding]; other site 761659007742 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 761659007743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007744 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 761659007745 Walker A/P-loop; other site 761659007746 ATP binding site [chemical binding]; other site 761659007747 Q-loop/lid; other site 761659007748 ABC transporter signature motif; other site 761659007749 Walker B; other site 761659007750 D-loop; other site 761659007751 H-loop/switch region; other site 761659007752 Predicted membrane protein [Function unknown]; Region: COG2259 761659007753 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 761659007754 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 761659007755 Low molecular weight phosphatase family; Region: LMWPc; cd00115 761659007756 active site 761659007757 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 761659007758 arsenical-resistance protein; Region: acr3; TIGR00832 761659007759 Methyltransferase domain; Region: Methyltransf_31; pfam13847 761659007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659007761 S-adenosylmethionine binding site [chemical binding]; other site 761659007762 potential protein location (conserved hypothetical protein) that overlaps protein (methyltransferase) 761659007763 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 761659007764 DinB family; Region: DinB; cl17821 761659007765 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 761659007766 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 761659007767 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 761659007768 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 761659007769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007770 Walker A/P-loop; other site 761659007771 ATP binding site [chemical binding]; other site 761659007772 Q-loop/lid; other site 761659007773 ABC transporter signature motif; other site 761659007774 Walker B; other site 761659007775 D-loop; other site 761659007776 H-loop/switch region; other site 761659007777 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 761659007778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 761659007779 dimer interface [polypeptide binding]; other site 761659007780 ABC-ATPase subunit interface; other site 761659007781 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 761659007782 CHY zinc finger; Region: zf-CHY; pfam05495 761659007783 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 761659007784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007785 Walker A/P-loop; other site 761659007786 ATP binding site [chemical binding]; other site 761659007787 Q-loop/lid; other site 761659007788 ABC transporter signature motif; other site 761659007789 Walker B; other site 761659007790 D-loop; other site 761659007791 H-loop/switch region; other site 761659007792 CAAX protease self-immunity; Region: Abi; pfam02517 761659007793 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 761659007794 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 761659007795 active site 761659007796 Zn binding site [ion binding]; other site 761659007797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659007799 dimerization interface [polypeptide binding]; other site 761659007800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007801 dimer interface [polypeptide binding]; other site 761659007802 phosphorylation site [posttranslational modification] 761659007803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007804 ATP binding site [chemical binding]; other site 761659007805 Mg2+ binding site [ion binding]; other site 761659007806 G-X-G motif; other site 761659007807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659007808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007809 active site 761659007810 phosphorylation site [posttranslational modification] 761659007811 intermolecular recognition site; other site 761659007812 dimerization interface [polypeptide binding]; other site 761659007813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659007814 DNA binding site [nucleotide binding] 761659007815 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 761659007816 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 761659007817 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 761659007818 oligomer interface [polypeptide binding]; other site 761659007819 active site 761659007820 metal binding site [ion binding]; metal-binding site 761659007821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659007822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007823 active site 761659007824 phosphorylation site [posttranslational modification] 761659007825 intermolecular recognition site; other site 761659007826 dimerization interface [polypeptide binding]; other site 761659007827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659007828 DNA binding site [nucleotide binding] 761659007829 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659007830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659007831 active site 761659007832 phosphorylation site [posttranslational modification] 761659007833 intermolecular recognition site; other site 761659007834 dimerization interface [polypeptide binding]; other site 761659007835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659007836 DNA binding site [nucleotide binding] 761659007837 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 761659007838 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 761659007839 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 761659007840 Ligand Binding Site [chemical binding]; other site 761659007841 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 761659007842 homotrimer interaction site [polypeptide binding]; other site 761659007843 putative active site [active] 761659007844 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 761659007845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 761659007846 active site 761659007847 metal binding site [ion binding]; metal-binding site 761659007848 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 761659007849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659007850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659007851 DNA binding residues [nucleotide binding] 761659007852 DNA repair protein RadA; Provisional; Region: PRK11823 761659007853 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 761659007854 Walker A motif/ATP binding site; other site 761659007855 ATP binding site [chemical binding]; other site 761659007856 Walker B motif; other site 761659007857 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 761659007858 Permease; Region: Permease; pfam02405 761659007859 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 761659007860 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 761659007861 Walker A/P-loop; other site 761659007862 ATP binding site [chemical binding]; other site 761659007863 Q-loop/lid; other site 761659007864 ABC transporter signature motif; other site 761659007865 Walker B; other site 761659007866 D-loop; other site 761659007867 H-loop/switch region; other site 761659007868 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 761659007869 mce related protein; Region: MCE; pfam02470 761659007870 Protein of unknown function (DUF445); Region: DUF445; pfam04286 761659007871 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 761659007872 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 761659007873 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 761659007874 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 761659007875 SCP-2 sterol transfer family; Region: SCP2; cl01225 761659007876 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 761659007877 FOG: CBS domain [General function prediction only]; Region: COG0517 761659007878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007879 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659007880 putative active site [active] 761659007881 heme pocket [chemical binding]; other site 761659007882 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 761659007883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007884 putative active site [active] 761659007885 heme pocket [chemical binding]; other site 761659007886 PAS fold; Region: PAS_3; pfam08447 761659007887 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 761659007888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007890 dimer interface [polypeptide binding]; other site 761659007891 phosphorylation site [posttranslational modification] 761659007892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007893 ATP binding site [chemical binding]; other site 761659007894 Mg2+ binding site [ion binding]; other site 761659007895 G-X-G motif; other site 761659007896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 761659007897 dimerization interface [polypeptide binding]; other site 761659007898 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659007899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659007900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659007901 dimer interface [polypeptide binding]; other site 761659007902 putative CheW interface [polypeptide binding]; other site 761659007903 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 761659007904 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 761659007905 PAS domain; Region: PAS_9; pfam13426 761659007906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659007907 putative active site [active] 761659007908 heme pocket [chemical binding]; other site 761659007909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659007910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007911 dimer interface [polypeptide binding]; other site 761659007912 phosphorylation site [posttranslational modification] 761659007913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007914 ATP binding site [chemical binding]; other site 761659007915 Mg2+ binding site [ion binding]; other site 761659007916 G-X-G motif; other site 761659007917 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 761659007918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659007919 dimer interface [polypeptide binding]; other site 761659007920 phosphorylation site [posttranslational modification] 761659007921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659007922 ATP binding site [chemical binding]; other site 761659007923 Mg2+ binding site [ion binding]; other site 761659007924 G-X-G motif; other site 761659007925 HDOD domain; Region: HDOD; pfam08668 761659007926 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 761659007927 SPFH domain / Band 7 family; Region: Band_7; pfam01145 761659007928 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 761659007929 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 761659007930 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 761659007931 nucleoside/Zn binding site; other site 761659007932 dimer interface [polypeptide binding]; other site 761659007933 catalytic motif [active] 761659007934 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 761659007935 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 761659007936 FMN binding site [chemical binding]; other site 761659007937 active site 761659007938 catalytic residues [active] 761659007939 substrate binding site [chemical binding]; other site 761659007940 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 761659007941 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 761659007942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659007943 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 761659007944 Walker A/P-loop; other site 761659007945 ATP binding site [chemical binding]; other site 761659007946 Q-loop/lid; other site 761659007947 ABC transporter signature motif; other site 761659007948 Walker B; other site 761659007949 D-loop; other site 761659007950 H-loop/switch region; other site 761659007951 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 761659007952 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 761659007953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 761659007954 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 761659007955 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 761659007956 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 761659007957 active site 761659007958 trimer interface [polypeptide binding]; other site 761659007959 allosteric site; other site 761659007960 active site lid [active] 761659007961 hexamer (dimer of trimers) interface [polypeptide binding]; other site 761659007962 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 761659007963 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 761659007964 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 761659007965 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 761659007966 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 761659007967 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 761659007968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 761659007969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 761659007970 potential frameshift: common BLAST hit: gi|83816015|ref|YP_446634.1| AP endonuclease 761659007971 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 761659007972 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 761659007973 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 761659007974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 761659007975 dimerization interface [polypeptide binding]; other site 761659007976 putative DNA binding site [nucleotide binding]; other site 761659007977 putative Zn2+ binding site [ion binding]; other site 761659007978 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659007979 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659007980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659007981 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 761659007982 prolyl-tRNA synthetase; Provisional; Region: PRK08661 761659007983 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 761659007984 dimer interface [polypeptide binding]; other site 761659007985 motif 1; other site 761659007986 active site 761659007987 motif 2; other site 761659007988 motif 3; other site 761659007989 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 761659007990 anticodon binding site; other site 761659007991 zinc-binding site [ion binding]; other site 761659007992 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 761659007993 YceG-like family; Region: YceG; pfam02618 761659007994 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 761659007995 dimerization interface [polypeptide binding]; other site 761659007996 UGMP family protein; Validated; Region: PRK09604 761659007997 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 761659007998 Oligomerisation domain; Region: Oligomerisation; pfam02410 761659007999 Protein of unknown function (DUF423); Region: DUF423; pfam04241 761659008000 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 761659008001 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659008002 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 761659008003 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659008004 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 761659008005 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 761659008006 cell surface protein SprA; Region: surface_SprA; TIGR04189 761659008007 Motility related/secretion protein; Region: SprA_N; pfam14349 761659008008 Motility related/secretion protein; Region: SprA_N; pfam14349 761659008009 Motility related/secretion protein; Region: SprA_N; pfam14349 761659008010 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 761659008011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659008012 NAD(P) binding site [chemical binding]; other site 761659008013 recombination protein RecR; Reviewed; Region: recR; PRK00076 761659008014 RecR protein; Region: RecR; pfam02132 761659008015 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 761659008016 putative active site [active] 761659008017 putative metal-binding site [ion binding]; other site 761659008018 tetramer interface [polypeptide binding]; other site 761659008019 hypothetical protein; Validated; Region: PRK00153 761659008020 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 761659008021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659008022 Walker A motif; other site 761659008023 ATP binding site [chemical binding]; other site 761659008024 Walker B motif; other site 761659008025 arginine finger; other site 761659008026 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 761659008027 RDD family; Region: RDD; pfam06271 761659008028 thymidine kinase; Provisional; Region: PRK04296 761659008029 Predicted membrane protein [Function unknown]; Region: COG2860 761659008030 UPF0126 domain; Region: UPF0126; pfam03458 761659008031 UPF0126 domain; Region: UPF0126; pfam03458 761659008032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659008033 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 761659008034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 761659008035 MarC family integral membrane protein; Region: MarC; cl00919 761659008036 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 761659008037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 761659008038 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 761659008039 dimerization interface [polypeptide binding]; other site 761659008040 substrate binding pocket [chemical binding]; other site 761659008041 TPR repeat; Region: TPR_11; pfam13414 761659008042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659008043 binding surface 761659008044 TPR motif; other site 761659008045 Oxygen tolerance; Region: BatD; pfam13584 761659008046 von Willebrand factor type A domain; Region: VWA_2; pfam13519 761659008047 metal ion-dependent adhesion site (MIDAS); other site 761659008048 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 761659008049 metal ion-dependent adhesion site (MIDAS); other site 761659008050 NAD-dependent deacetylase; Provisional; Region: PRK00481 761659008051 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 761659008052 NAD+ binding site [chemical binding]; other site 761659008053 substrate binding site [chemical binding]; other site 761659008054 Zn binding site [ion binding]; other site 761659008055 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 761659008056 Protein of unknown function DUF58; Region: DUF58; pfam01882 761659008057 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 761659008058 metal ion-dependent adhesion site (MIDAS); other site 761659008059 PAS domain S-box; Region: sensory_box; TIGR00229 761659008060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659008062 dimer interface [polypeptide binding]; other site 761659008063 phosphorylation site [posttranslational modification] 761659008064 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 761659008065 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 761659008066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 761659008067 FeS/SAM binding site; other site 761659008068 TRAM domain; Region: TRAM; pfam01938 761659008069 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 761659008070 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 761659008071 putative active site [active] 761659008072 putative metal binding site [ion binding]; other site 761659008073 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 761659008074 HDOD domain; Region: HDOD; pfam08668 761659008075 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 761659008076 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 761659008077 HAMP domain; Region: HAMP; pfam00672 761659008078 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659008079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008080 dimer interface [polypeptide binding]; other site 761659008081 putative CheW interface [polypeptide binding]; other site 761659008082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659008083 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 761659008084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 761659008085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659008086 DNA binding residues [nucleotide binding] 761659008087 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 761659008088 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 761659008089 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 761659008090 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 761659008091 AAA domain; Region: AAA_17; pfam13207 761659008092 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 761659008093 FHIPEP family; Region: FHIPEP; pfam00771 761659008094 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 761659008095 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 761659008096 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 761659008097 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 761659008098 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 761659008099 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 761659008100 flagellar motor switch protein FliN; Region: fliN; TIGR02480 761659008101 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 761659008102 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 761659008103 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 761659008104 flagellar motor protein MotS; Reviewed; Region: PRK06925 761659008105 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 761659008106 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 761659008107 ligand binding site [chemical binding]; other site 761659008108 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 761659008109 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 761659008110 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659008111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008112 dimer interface [polypeptide binding]; other site 761659008113 putative CheW interface [polypeptide binding]; other site 761659008114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008115 dimerization interface [polypeptide binding]; other site 761659008116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008117 dimerization interface [polypeptide binding]; other site 761659008118 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 761659008119 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008120 dimer interface [polypeptide binding]; other site 761659008121 putative CheW interface [polypeptide binding]; other site 761659008122 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 761659008123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008124 dimerization interface [polypeptide binding]; other site 761659008125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008126 dimerization interface [polypeptide binding]; other site 761659008127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659008128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008129 dimer interface [polypeptide binding]; other site 761659008130 putative CheW interface [polypeptide binding]; other site 761659008131 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 761659008132 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 761659008133 N-acetyl-D-glucosamine binding site [chemical binding]; other site 761659008134 catalytic residue [active] 761659008135 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 761659008136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008137 active site 761659008138 phosphorylation site [posttranslational modification] 761659008139 intermolecular recognition site; other site 761659008140 dimerization interface [polypeptide binding]; other site 761659008141 CheB methylesterase; Region: CheB_methylest; pfam01339 761659008142 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 761659008143 putative binding surface; other site 761659008144 active site 761659008145 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 761659008146 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 761659008147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008148 ATP binding site [chemical binding]; other site 761659008149 Mg2+ binding site [ion binding]; other site 761659008150 G-X-G motif; other site 761659008151 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 761659008152 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 761659008153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008154 active site 761659008155 phosphorylation site [posttranslational modification] 761659008156 intermolecular recognition site; other site 761659008157 dimerization interface [polypeptide binding]; other site 761659008158 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 761659008159 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 761659008160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659008161 S-adenosylmethionine binding site [chemical binding]; other site 761659008162 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 761659008163 putative CheA interaction surface; other site 761659008164 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 761659008165 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 761659008166 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 761659008167 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 761659008168 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 761659008169 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 761659008170 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 761659008171 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 761659008172 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 761659008173 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 761659008174 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 761659008175 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 761659008176 Walker A motif/ATP binding site; other site 761659008177 Walker B motif; other site 761659008178 Flagellar assembly protein FliH; Region: FliH; pfam02108 761659008179 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 761659008180 FliG C-terminal domain; Region: FliG_C; pfam01706 761659008181 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 761659008182 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 761659008183 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 761659008184 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 761659008185 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 761659008186 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 761659008187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008189 ATP binding site [chemical binding]; other site 761659008190 G-X-G motif; other site 761659008191 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 761659008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008193 active site 761659008194 phosphorylation site [posttranslational modification] 761659008195 intermolecular recognition site; other site 761659008196 dimerization interface [polypeptide binding]; other site 761659008197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659008198 Walker A motif; other site 761659008199 ATP binding site [chemical binding]; other site 761659008200 Walker B motif; other site 761659008201 arginine finger; other site 761659008202 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659008203 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 761659008204 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 761659008205 Flagellar protein FliS; Region: FliS; cl00654 761659008206 sulfotransferase; Region: PLN02164 761659008207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659008208 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659008209 DNA-binding interface [nucleotide binding]; DNA binding site 761659008210 Winged helix-turn helix; Region: HTH_29; pfam13551 761659008211 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 761659008212 Homeodomain-like domain; Region: HTH_32; pfam13565 761659008213 DDE superfamily endonuclease; Region: DDE_3; pfam13358 761659008214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 761659008215 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 761659008216 flagellin; Reviewed; Region: PRK08869 761659008217 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 761659008218 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 761659008219 sulfotransferase; Region: PLN02164 761659008220 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659008221 HDOD domain; Region: HDOD; pfam08668 761659008222 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 761659008223 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 761659008224 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 761659008225 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 761659008226 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 761659008227 Flagellar L-ring protein; Region: FlgH; cl17277 761659008228 SAF-like; Region: SAF_2; pfam13144 761659008229 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 761659008230 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 761659008231 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 761659008232 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 761659008233 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 761659008234 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 761659008235 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 761659008236 Uncharacterized conserved protein [Function unknown]; Region: COG1262 761659008237 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 761659008238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659008239 Walker A motif; other site 761659008240 ATP binding site [chemical binding]; other site 761659008241 Walker B motif; other site 761659008242 arginine finger; other site 761659008243 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 761659008244 Lipopolysaccharide-assembly; Region: LptE; cl01125 761659008245 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 761659008246 active site 761659008247 dimer interface [polypeptide binding]; other site 761659008248 catalytic nucleophile [active] 761659008249 thioester reductase domain; Region: Thioester-redct; TIGR01746 761659008250 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 761659008251 putative NAD(P) binding site [chemical binding]; other site 761659008252 active site 761659008253 putative substrate binding site [chemical binding]; other site 761659008254 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 761659008255 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 761659008256 RES domain; Region: RES; smart00953 761659008257 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 761659008258 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 761659008259 dimerization interface [polypeptide binding]; other site 761659008260 ATP binding site [chemical binding]; other site 761659008261 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 761659008262 dimerization interface [polypeptide binding]; other site 761659008263 ATP binding site [chemical binding]; other site 761659008264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 761659008265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659008266 catalytic residues [active] 761659008267 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 761659008268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 761659008269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 761659008270 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 761659008271 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 761659008272 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 761659008273 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 761659008274 Sulfatase; Region: Sulfatase; cl17466 761659008275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659008276 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 761659008277 Transcriptional regulator; Region: Transcrip_reg; pfam01709 761659008278 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 761659008279 active site 761659008280 putative DNA-binding cleft [nucleotide binding]; other site 761659008281 dimer interface [polypeptide binding]; other site 761659008282 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 761659008283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659008284 Walker A/P-loop; other site 761659008285 ATP binding site [chemical binding]; other site 761659008286 Q-loop/lid; other site 761659008287 ABC transporter signature motif; other site 761659008288 Walker B; other site 761659008289 D-loop; other site 761659008290 H-loop/switch region; other site 761659008291 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 761659008292 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 761659008293 trigger factor; Region: tig; TIGR00115 761659008294 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 761659008295 Clp protease; Region: CLP_protease; pfam00574 761659008296 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 761659008297 oligomer interface [polypeptide binding]; other site 761659008298 active site residues [active] 761659008299 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 761659008300 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 761659008301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 761659008302 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 761659008303 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 761659008304 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 761659008305 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 761659008306 classical (c) SDRs; Region: SDR_c; cd05233 761659008307 NAD(P) binding site [chemical binding]; other site 761659008308 active site 761659008309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659008310 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 761659008311 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 761659008312 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 761659008313 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 761659008314 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 761659008315 active site 761659008316 nucleophile elbow; other site 761659008317 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 761659008318 ABC1 family; Region: ABC1; cl17513 761659008319 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 761659008320 ABC1 family; Region: ABC1; cl17513 761659008321 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 761659008322 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 761659008323 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 761659008324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 761659008325 active site 761659008326 Galactose oxidase, central domain; Region: Kelch_3; cl02701 761659008327 Kelch motif; Region: Kelch_1; pfam01344 761659008328 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 761659008329 Ferrochelatase; Region: Ferrochelatase; pfam00762 761659008330 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 761659008331 C-terminal domain interface [polypeptide binding]; other site 761659008332 active site 761659008333 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 761659008334 active site 761659008335 N-terminal domain interface [polypeptide binding]; other site 761659008336 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659008337 putative catalytic site [active] 761659008338 putative metal binding site [ion binding]; other site 761659008339 putative phosphate binding site [ion binding]; other site 761659008340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 761659008341 ligand binding site [chemical binding]; other site 761659008342 Domain of unknown function (DUF368); Region: DUF368; pfam04018 761659008343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659008344 binding surface 761659008345 Bacterial transcriptional activator domain; Region: BTAD; smart01043 761659008346 TPR motif; other site 761659008347 TPR repeat; Region: TPR_11; pfam13414 761659008348 TPR repeat; Region: TPR_11; pfam13414 761659008349 Tetratricopeptide repeat; Region: TPR_16; pfam13432 761659008350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659008351 binding surface 761659008352 TPR motif; other site 761659008353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659008354 Tetratricopeptide repeat; Region: TPR_12; pfam13424 761659008355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659008356 binding surface 761659008357 TPR motif; other site 761659008358 TPR repeat; Region: TPR_11; pfam13414 761659008359 TPR repeat; Region: TPR_11; pfam13414 761659008360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 761659008361 binding surface 761659008362 TPR motif; other site 761659008363 TPR repeat; Region: TPR_11; pfam13414 761659008364 thymidylate kinase; Validated; Region: tmk; PRK00698 761659008365 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 761659008366 TMP-binding site; other site 761659008367 ATP-binding site [chemical binding]; other site 761659008368 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 761659008369 metal binding site 2 [ion binding]; metal-binding site 761659008370 putative DNA binding helix; other site 761659008371 metal binding site 1 [ion binding]; metal-binding site 761659008372 dimer interface [polypeptide binding]; other site 761659008373 structural Zn2+ binding site [ion binding]; other site 761659008374 PrcB C-terminal; Region: PrcB_C; pfam14343 761659008375 Mechanosensitive ion channel; Region: MS_channel; pfam00924 761659008376 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 761659008377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 761659008378 NAD binding site [chemical binding]; other site 761659008379 putative substrate binding site 2 [chemical binding]; other site 761659008380 putative substrate binding site 1 [chemical binding]; other site 761659008381 active site 761659008382 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 761659008383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 761659008384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 761659008385 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 761659008386 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 761659008387 putative catalytic residue [active] 761659008388 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 761659008389 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 761659008390 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 761659008391 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 761659008392 DsbD alpha interface [polypeptide binding]; other site 761659008393 catalytic residues [active] 761659008394 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 761659008395 Ca2+ binding site [ion binding]; other site 761659008396 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 761659008397 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 761659008398 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 761659008399 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 761659008400 active site 761659008401 Zn binding site [ion binding]; other site 761659008402 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 761659008403 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 761659008404 multidrug efflux protein; Reviewed; Region: PRK01766 761659008405 cation binding site [ion binding]; other site 761659008406 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 761659008407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659008408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 761659008409 Beta-lactamase; Region: Beta-lactamase; pfam00144 761659008410 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 761659008411 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 761659008412 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 761659008413 Histidine kinase; Region: His_kinase; pfam06580 761659008414 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 761659008415 ATP binding site [chemical binding]; other site 761659008416 Mg2+ binding site [ion binding]; other site 761659008417 G-X-G motif; other site 761659008418 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659008419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008420 active site 761659008421 phosphorylation site [posttranslational modification] 761659008422 intermolecular recognition site; other site 761659008423 dimerization interface [polypeptide binding]; other site 761659008424 LytTr DNA-binding domain; Region: LytTR; smart00850 761659008425 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 761659008426 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659008427 N-terminal plug; other site 761659008428 ligand-binding site [chemical binding]; other site 761659008429 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 761659008430 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 761659008431 putative hemin binding site; other site 761659008432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 761659008433 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 761659008434 putative PBP binding regions; other site 761659008435 ABC-ATPase subunit interface; other site 761659008436 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 761659008437 Peptidase family M28; Region: Peptidase_M28; pfam04389 761659008438 metal binding site [ion binding]; metal-binding site 761659008439 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 761659008440 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 761659008441 Walker A/P-loop; other site 761659008442 ATP binding site [chemical binding]; other site 761659008443 Q-loop/lid; other site 761659008444 ABC transporter signature motif; other site 761659008445 Walker B; other site 761659008446 D-loop; other site 761659008447 H-loop/switch region; other site 761659008448 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 761659008449 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 761659008450 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 761659008451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659008452 S-adenosylmethionine binding site [chemical binding]; other site 761659008453 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 761659008454 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 761659008455 N-terminal plug; other site 761659008456 ligand-binding site [chemical binding]; other site 761659008457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 761659008458 active site residue [active] 761659008459 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659008460 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659008461 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 761659008462 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 761659008463 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 761659008464 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 761659008465 dimer interface [polypeptide binding]; other site 761659008466 active site 761659008467 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 761659008468 CoenzymeA binding site [chemical binding]; other site 761659008469 subunit interaction site [polypeptide binding]; other site 761659008470 PHB binding site; other site 761659008471 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 761659008472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659008473 Zn binding site [ion binding]; other site 761659008474 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 761659008475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659008476 Zn binding site [ion binding]; other site 761659008477 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 761659008478 putative hydrolase; Provisional; Region: PRK11460 761659008479 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 761659008480 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 761659008481 active site 761659008482 homodimer interface [polypeptide binding]; other site 761659008483 catalytic site [active] 761659008484 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 761659008485 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 761659008486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659008487 primosomal protein N' Region: priA; TIGR00595 761659008488 ATP binding site [chemical binding]; other site 761659008489 putative Mg++ binding site [ion binding]; other site 761659008490 transcriptional activator RfaH; Region: RfaH; TIGR01955 761659008491 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 761659008492 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 761659008493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659008494 ATP binding site [chemical binding]; other site 761659008495 putative Mg++ binding site [ion binding]; other site 761659008496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 761659008497 nucleotide binding region [chemical binding]; other site 761659008498 ATP-binding site [chemical binding]; other site 761659008499 Helicase associated domain (HA2); Region: HA2; pfam04408 761659008500 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 761659008501 putative phosphatase; Provisional; Region: PRK11587 761659008502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 761659008503 active site 761659008504 motif I; other site 761659008505 motif II; other site 761659008506 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 761659008507 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 761659008508 active site 761659008509 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 761659008510 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 761659008511 Protein of unknown function (DUF721); Region: DUF721; pfam05258 761659008512 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 761659008513 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 761659008514 dimer interface [polypeptide binding]; other site 761659008515 active site 761659008516 acyl carrier protein; Provisional; Region: acpP; PRK00982 761659008517 S-adenosylmethionine synthetase; Validated; Region: PRK05250 761659008518 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 761659008519 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 761659008520 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 761659008521 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 761659008522 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 761659008523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659008524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659008525 DNA binding residues [nucleotide binding] 761659008526 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 761659008527 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 761659008528 glycogen binding site [chemical binding]; other site 761659008529 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 761659008530 catalytic nucleophile [active] 761659008531 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 761659008532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 761659008533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 761659008534 DNA binding residues [nucleotide binding] 761659008535 Protein of unknown function (DUF971); Region: DUF971; pfam06155 761659008536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 761659008537 ATP binding site [chemical binding]; other site 761659008538 putative Mg++ binding site [ion binding]; other site 761659008539 nucleotide binding region [chemical binding]; other site 761659008540 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 761659008541 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 761659008542 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 761659008543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 761659008544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 761659008545 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 761659008546 substrate binding site [chemical binding]; other site 761659008547 oxyanion hole (OAH) forming residues; other site 761659008548 trimer interface [polypeptide binding]; other site 761659008549 Predicted dehydrogenase [General function prediction only]; Region: COG0579 761659008550 hydroxyglutarate oxidase; Provisional; Region: PRK11728 761659008551 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 761659008552 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 761659008553 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 761659008554 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 761659008555 putative active site [active] 761659008556 putative dimer interface [polypeptide binding]; other site 761659008557 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 761659008558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 761659008559 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 761659008560 Transposase; Region: DEDD_Tnp_IS110; pfam01548 761659008561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 761659008562 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 761659008563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659008564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659008565 Uncharacterized conserved protein [Function unknown]; Region: COG2128 761659008566 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 761659008567 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 761659008568 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 761659008569 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 761659008570 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 761659008571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 761659008572 NAD(P) binding site [chemical binding]; other site 761659008573 active site 761659008574 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 761659008575 Na binding site [ion binding]; other site 761659008576 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 761659008577 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 761659008578 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 761659008579 classical (c) SDRs; Region: SDR_c; cd05233 761659008580 NAD(P) binding site [chemical binding]; other site 761659008581 active site 761659008582 5' nucleotidase family; Region: 5_nucleotid; pfam05761 761659008583 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 761659008584 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 761659008585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 761659008586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 761659008587 WHG domain; Region: WHG; pfam13305 761659008588 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 761659008589 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 761659008590 dimer interface [polypeptide binding]; other site 761659008591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 761659008592 catalytic residue [active] 761659008593 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 761659008594 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 761659008595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 761659008596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008597 active site 761659008598 phosphorylation site [posttranslational modification] 761659008599 intermolecular recognition site; other site 761659008600 dimerization interface [polypeptide binding]; other site 761659008601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 761659008602 DNA binding residues [nucleotide binding] 761659008603 dimerization interface [polypeptide binding]; other site 761659008604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 761659008605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008606 active site 761659008607 phosphorylation site [posttranslational modification] 761659008608 intermolecular recognition site; other site 761659008609 dimerization interface [polypeptide binding]; other site 761659008610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 761659008611 DNA binding residues [nucleotide binding] 761659008612 dimerization interface [polypeptide binding]; other site 761659008613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008614 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 761659008615 dimer interface [polypeptide binding]; other site 761659008616 phosphorylation site [posttranslational modification] 761659008617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008618 ATP binding site [chemical binding]; other site 761659008619 Mg2+ binding site [ion binding]; other site 761659008620 G-X-G motif; other site 761659008621 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 761659008622 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 761659008623 CoA-binding site [chemical binding]; other site 761659008624 ATP-binding [chemical binding]; other site 761659008625 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 761659008626 nucleotide binding site/active site [active] 761659008627 HIT family signature motif; other site 761659008628 catalytic residue [active] 761659008629 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 761659008630 active site 761659008631 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 761659008632 homodecamer interface [polypeptide binding]; other site 761659008633 GTP cyclohydrolase I; Provisional; Region: PLN03044 761659008634 active site 761659008635 putative catalytic site residues [active] 761659008636 zinc binding site [ion binding]; other site 761659008637 GTP-CH-I/GFRP interaction surface; other site 761659008638 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 761659008639 classical (c) SDRs; Region: SDR_c; cd05233 761659008640 NAD(P) binding site [chemical binding]; other site 761659008641 active site 761659008642 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 761659008643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 761659008644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 761659008645 Coenzyme A binding pocket [chemical binding]; other site 761659008646 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013 761659008647 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 761659008648 metal binding site [ion binding]; metal-binding site 761659008649 putative dimer interface [polypeptide binding]; other site 761659008650 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 761659008651 Active_site [active] 761659008652 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 761659008653 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 761659008654 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 761659008655 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 761659008656 active site 761659008657 dimer interface [polypeptide binding]; other site 761659008658 motif 1; other site 761659008659 motif 2; other site 761659008660 motif 3; other site 761659008661 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 761659008662 anticodon binding site; other site 761659008663 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 761659008664 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 761659008665 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 761659008666 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 761659008667 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 761659008668 23S rRNA binding site [nucleotide binding]; other site 761659008669 L21 binding site [polypeptide binding]; other site 761659008670 L13 binding site [polypeptide binding]; other site 761659008671 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 761659008672 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 761659008673 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 761659008674 dimer interface [polypeptide binding]; other site 761659008675 motif 1; other site 761659008676 active site 761659008677 motif 2; other site 761659008678 motif 3; other site 761659008679 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 761659008680 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 761659008681 putative tRNA-binding site [nucleotide binding]; other site 761659008682 B3/4 domain; Region: B3_4; pfam03483 761659008683 tRNA synthetase B5 domain; Region: B5; smart00874 761659008684 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 761659008685 dimer interface [polypeptide binding]; other site 761659008686 motif 1; other site 761659008687 motif 3; other site 761659008688 motif 2; other site 761659008689 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 761659008690 Cell division protein ZapA; Region: ZapA; pfam05164 761659008691 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 761659008692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 761659008693 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 761659008694 ABC transporter; Region: ABC_tran_2; pfam12848 761659008695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 761659008696 FG-GAP repeat; Region: FG-GAP_2; pfam14312 761659008697 FG-GAP repeat; Region: FG-GAP_2; pfam14312 761659008698 FG-GAP repeat; Region: FG-GAP_2; pfam14312 761659008699 Glyco_18 domain; Region: Glyco_18; smart00636 761659008700 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 761659008701 active site 761659008702 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 761659008703 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 761659008704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659008705 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 761659008706 active site 761659008707 putative addiction module antidote; Region: doc_partner; TIGR02609 761659008708 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 761659008709 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 761659008710 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659008711 catalytic residues [active] 761659008712 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 761659008713 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 761659008714 catalytic residues [active] 761659008715 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 761659008716 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 761659008717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 761659008718 S-adenosylmethionine binding site [chemical binding]; other site 761659008719 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 761659008720 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 761659008721 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 761659008722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008723 dimerization interface [polypeptide binding]; other site 761659008724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008725 dimer interface [polypeptide binding]; other site 761659008726 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 761659008727 putative CheW interface [polypeptide binding]; other site 761659008728 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 761659008729 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659008730 HlyD family secretion protein; Region: HlyD_3; pfam13437 761659008731 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 761659008732 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 761659008733 Nitrogen regulatory protein P-II; Region: P-II; smart00938 761659008734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 761659008735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008736 active site 761659008737 phosphorylation site [posttranslational modification] 761659008738 intermolecular recognition site; other site 761659008739 dimerization interface [polypeptide binding]; other site 761659008740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 761659008741 DNA binding site [nucleotide binding] 761659008742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 761659008744 dimerization interface [polypeptide binding]; other site 761659008745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659008746 dimer interface [polypeptide binding]; other site 761659008747 phosphorylation site [posttranslational modification] 761659008748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008749 ATP binding site [chemical binding]; other site 761659008750 Mg2+ binding site [ion binding]; other site 761659008751 G-X-G motif; other site 761659008752 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 761659008753 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 761659008754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 761659008755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 761659008756 dimer interface [polypeptide binding]; other site 761659008757 putative CheW interface [polypeptide binding]; other site 761659008758 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 761659008759 Clp amino terminal domain; Region: Clp_N; pfam02861 761659008760 Clp amino terminal domain; Region: Clp_N; pfam02861 761659008761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659008762 Walker A motif; other site 761659008763 ATP binding site [chemical binding]; other site 761659008764 Walker B motif; other site 761659008765 arginine finger; other site 761659008766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 761659008767 Walker A motif; other site 761659008768 ATP binding site [chemical binding]; other site 761659008769 Walker B motif; other site 761659008770 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 761659008771 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 761659008772 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 761659008773 Cupin domain; Region: Cupin_2; cl17218 761659008774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 761659008775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 761659008776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 761659008777 Walker A/P-loop; other site 761659008778 ATP binding site [chemical binding]; other site 761659008779 Q-loop/lid; other site 761659008780 ABC transporter signature motif; other site 761659008781 Walker B; other site 761659008782 D-loop; other site 761659008783 H-loop/switch region; other site 761659008784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 761659008785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 761659008786 DNA binding site [nucleotide binding] 761659008787 domain linker motif; other site 761659008788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 761659008789 ligand binding site [chemical binding]; other site 761659008790 dimerization interface [polypeptide binding]; other site 761659008791 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 761659008792 putative transporter; Provisional; Region: PRK10484 761659008793 Na binding site [ion binding]; other site 761659008794 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659008795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659008796 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659008797 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659008798 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 761659008799 starch binding outer membrane protein SusD; Region: SusD; cd08977 761659008800 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659008801 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 761659008802 active site 761659008803 catalytic residues [active] 761659008804 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 761659008805 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 761659008806 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 761659008807 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 761659008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659008809 putative substrate translocation pore; other site 761659008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 761659008811 Cna protein B-type domain; Region: Cna_B_2; pfam13715 761659008812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 761659008813 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 761659008814 Walker A/P-loop; other site 761659008815 ATP binding site [chemical binding]; other site 761659008816 Q-loop/lid; other site 761659008817 ABC transporter signature motif; other site 761659008818 Walker B; other site 761659008819 D-loop; other site 761659008820 H-loop/switch region; other site 761659008821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 761659008822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 761659008823 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 761659008824 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 761659008825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659008826 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 761659008827 FtsX-like permease family; Region: FtsX; pfam02687 761659008828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 761659008829 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 761659008830 FtsX-like permease family; Region: FtsX; pfam02687 761659008831 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659008832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008833 active site 761659008834 phosphorylation site [posttranslational modification] 761659008835 intermolecular recognition site; other site 761659008836 dimerization interface [polypeptide binding]; other site 761659008837 LytTr DNA-binding domain; Region: LytTR; smart00850 761659008838 Histidine kinase; Region: His_kinase; pfam06580 761659008839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008840 ATP binding site [chemical binding]; other site 761659008841 Mg2+ binding site [ion binding]; other site 761659008842 G-X-G motif; other site 761659008843 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 761659008844 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 761659008845 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 761659008846 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659008847 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 761659008848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 761659008849 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 761659008850 starch binding outer membrane protein SusD; Region: SusD; cd08977 761659008851 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 761659008852 putative catalytic site [active] 761659008853 putative metal binding site [ion binding]; other site 761659008854 putative phosphate binding site [ion binding]; other site 761659008855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 761659008856 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 761659008857 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 761659008858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 761659008859 Zn binding site [ion binding]; other site 761659008860 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 761659008861 Zn binding site [ion binding]; other site 761659008862 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 761659008863 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 761659008864 putative active site [active] 761659008865 putative nucleic acid binding site [nucleotide binding]; other site 761659008866 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 761659008867 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 761659008868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 761659008869 active site 761659008870 potential frameshift: common BLAST hit: gi|222524796|ref|YP_002569267.1| transposase IS701 family protein 761659008871 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659008872 DDE superfamily endonuclease; Region: DDE_5; cl17874 761659008873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659008874 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659008875 DNA-binding interface [nucleotide binding]; DNA binding site 761659008876 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 761659008877 Curli assembly protein CsgE; Region: CsgE; cl08115 761659008878 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 761659008879 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 761659008880 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 761659008881 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 761659008882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008883 PAS fold; Region: PAS_3; pfam08447 761659008884 heme pocket [chemical binding]; other site 761659008885 putative active site [active] 761659008886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008887 PAS domain; Region: PAS_9; pfam13426 761659008888 putative active site [active] 761659008889 heme pocket [chemical binding]; other site 761659008890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659008892 dimer interface [polypeptide binding]; other site 761659008893 phosphorylation site [posttranslational modification] 761659008894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008895 ATP binding site [chemical binding]; other site 761659008896 Mg2+ binding site [ion binding]; other site 761659008897 G-X-G motif; other site 761659008898 CheB methylesterase; Region: CheB_methylest; pfam01339 761659008899 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 761659008900 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 761659008901 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 761659008902 PAS domain; Region: PAS_10; pfam13596 761659008903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008904 PAS domain; Region: PAS_9; pfam13426 761659008905 putative active site [active] 761659008906 heme pocket [chemical binding]; other site 761659008907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 761659008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008909 ATP binding site [chemical binding]; other site 761659008910 Mg2+ binding site [ion binding]; other site 761659008911 G-X-G motif; other site 761659008912 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008914 active site 761659008915 phosphorylation site [posttranslational modification] 761659008916 intermolecular recognition site; other site 761659008917 dimerization interface [polypeptide binding]; other site 761659008918 PAS domain S-box; Region: sensory_box; TIGR00229 761659008919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008920 putative active site [active] 761659008921 heme pocket [chemical binding]; other site 761659008922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008923 PAS domain; Region: PAS_9; pfam13426 761659008924 putative active site [active] 761659008925 heme pocket [chemical binding]; other site 761659008926 PAS domain; Region: PAS_9; pfam13426 761659008927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008928 PAS domain; Region: PAS_9; pfam13426 761659008929 putative active site [active] 761659008930 heme pocket [chemical binding]; other site 761659008931 PAS fold; Region: PAS_4; pfam08448 761659008932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659008933 PAS fold; Region: PAS_3; pfam08447 761659008934 putative active site [active] 761659008935 heme pocket [chemical binding]; other site 761659008936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659008937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659008938 dimer interface [polypeptide binding]; other site 761659008939 phosphorylation site [posttranslational modification] 761659008940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659008941 ATP binding site [chemical binding]; other site 761659008942 Mg2+ binding site [ion binding]; other site 761659008943 G-X-G motif; other site 761659008944 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 761659008945 active site 761659008946 catalytic residues [active] 761659008947 DNA binding site [nucleotide binding] 761659008948 Int/Topo IB signature motif; other site 761659008949 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 761659008950 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 761659008951 NADP binding site [chemical binding]; other site 761659008952 active site 761659008953 putative substrate binding site [chemical binding]; other site 761659008954 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 761659008955 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 761659008956 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 761659008957 substrate binding site; other site 761659008958 tetramer interface; other site 761659008959 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 761659008960 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 761659008961 NAD binding site [chemical binding]; other site 761659008962 substrate binding site [chemical binding]; other site 761659008963 homodimer interface [polypeptide binding]; other site 761659008964 active site 761659008965 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 761659008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008967 active site 761659008968 phosphorylation site [posttranslational modification] 761659008969 intermolecular recognition site; other site 761659008970 dimerization interface [polypeptide binding]; other site 761659008971 LytTr DNA-binding domain; Region: LytTR; smart00850 761659008972 potential frameshift: common BLAST hit: gi|256422715|ref|YP_003123368.1| glycosyl transferase family 2 761659008973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659008974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 761659008975 active site 761659008976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659008977 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 761659008978 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 761659008979 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 761659008980 DXD motif; other site 761659008981 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 761659008982 Right handed beta helix region; Region: Beta_helix; pfam13229 761659008983 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 761659008984 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 761659008985 Probable Catalytic site; other site 761659008986 metal-binding site 761659008987 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 761659008988 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 761659008989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 761659008990 putative homodimer interface [polypeptide binding]; other site 761659008991 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 761659008992 Bacterial sugar transferase; Region: Bac_transf; cl00939 761659008993 Bacterial sugar transferase; Region: Bac_transf; pfam02397 761659008994 Outer membrane efflux protein; Region: OEP; pfam02321 761659008995 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 761659008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659008997 Response regulator receiver domain; Region: Response_reg; pfam00072 761659008998 active site 761659008999 phosphorylation site [posttranslational modification] 761659009000 intermolecular recognition site; other site 761659009001 dimerization interface [polypeptide binding]; other site 761659009002 PAS domain; Region: PAS_9; pfam13426 761659009003 PAS domain S-box; Region: sensory_box; TIGR00229 761659009004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659009005 putative active site [active] 761659009006 heme pocket [chemical binding]; other site 761659009007 PAS domain S-box; Region: sensory_box; TIGR00229 761659009008 PAS domain S-box; Region: sensory_box; TIGR00229 761659009009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659009010 putative active site [active] 761659009011 heme pocket [chemical binding]; other site 761659009012 PAS domain S-box; Region: sensory_box; TIGR00229 761659009013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 761659009014 putative active site [active] 761659009015 heme pocket [chemical binding]; other site 761659009016 PAS fold; Region: PAS_4; pfam08448 761659009017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 761659009018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 761659009019 dimer interface [polypeptide binding]; other site 761659009020 phosphorylation site [posttranslational modification] 761659009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 761659009022 ATP binding site [chemical binding]; other site 761659009023 Mg2+ binding site [ion binding]; other site 761659009024 G-X-G motif; other site 761659009025 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 761659009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 761659009027 active site 761659009028 phosphorylation site [posttranslational modification] 761659009029 intermolecular recognition site; other site 761659009030 dimerization interface [polypeptide binding]; other site 761659009031 FIST N domain; Region: FIST; pfam08495 761659009032 FIST C domain; Region: FIST_C; pfam10442 761659009033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 761659009034 potential frameshift: common BLAST hit: gi|147678692|ref|YP_001212907.1| transposase and inactivated derivatives 761659009035 Transposase, Mutator family; Region: Transposase_mut; pfam00872 761659009036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 761659009037 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 761659009038 Catalytic site [active] 761659009039 Initiator Replication protein; Region: Rep_3; pfam01051 761659009040 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 761659009041 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 761659009042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 761659009043 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 761659009044 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 761659009045 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 761659009046 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 761659009047 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 761659009048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 761659009049 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 761659009050 DNA-binding interface [nucleotide binding]; DNA binding site