-- dump date 20140620_042818 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391037000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 391037000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037000003 Walker A motif; other site 391037000004 ATP binding site [chemical binding]; other site 391037000005 Walker B motif; other site 391037000006 arginine finger; other site 391037000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391037000008 DnaA box-binding interface [nucleotide binding]; other site 391037000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 391037000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391037000011 putative DNA binding surface [nucleotide binding]; other site 391037000012 dimer interface [polypeptide binding]; other site 391037000013 beta-clamp/clamp loader binding surface; other site 391037000014 beta-clamp/translesion DNA polymerase binding surface; other site 391037000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391037000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 391037000017 recombination protein F; Reviewed; Region: recF; PRK00064 391037000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 391037000019 Walker A/P-loop; other site 391037000020 ATP binding site [chemical binding]; other site 391037000021 Q-loop/lid; other site 391037000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037000023 ABC transporter signature motif; other site 391037000024 Walker B; other site 391037000025 D-loop; other site 391037000026 H-loop/switch region; other site 391037000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 391037000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 391037000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037000030 Mg2+ binding site [ion binding]; other site 391037000031 G-X-G motif; other site 391037000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391037000033 anchoring element; other site 391037000034 dimer interface [polypeptide binding]; other site 391037000035 ATP binding site [chemical binding]; other site 391037000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391037000037 active site 391037000038 putative metal-binding site [ion binding]; other site 391037000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391037000040 DNA gyrase subunit A; Validated; Region: PRK05560 391037000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391037000042 CAP-like domain; other site 391037000043 active site 391037000044 primary dimer interface [polypeptide binding]; other site 391037000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 391037000052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037000053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000054 non-specific DNA binding site [nucleotide binding]; other site 391037000055 salt bridge; other site 391037000056 sequence-specific DNA binding site [nucleotide binding]; other site 391037000057 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 391037000058 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037000059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037000060 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037000061 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 391037000062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037000063 active site 391037000064 HIGH motif; other site 391037000065 nucleotide binding site [chemical binding]; other site 391037000066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037000067 active site 391037000068 KMSKS motif; other site 391037000069 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391037000070 tRNA binding surface [nucleotide binding]; other site 391037000071 anticodon binding site; other site 391037000072 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391037000073 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 391037000074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391037000075 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 391037000076 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 391037000077 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391037000078 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 391037000079 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391037000080 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391037000081 catalytic residues [active] 391037000082 Fe-S metabolism associated domain; Region: SufE; cl00951 391037000083 FOG: CBS domain [General function prediction only]; Region: COG0517 391037000084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 391037000085 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 391037000086 active site 391037000087 catalytic triad [active] 391037000088 oxyanion hole [active] 391037000089 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391037000090 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391037000091 active site residue [active] 391037000092 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391037000093 active site residue [active] 391037000094 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 391037000095 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 391037000096 calcium binding site 2 [ion binding]; other site 391037000097 active site 391037000098 catalytic triad [active] 391037000099 calcium binding site 1 [ion binding]; other site 391037000100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037000101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037000102 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391037000103 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037000104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037000105 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 391037000106 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391037000107 active site 391037000108 catalytic residues [active] 391037000109 metal binding site [ion binding]; metal-binding site 391037000110 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391037000111 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391037000112 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391037000113 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037000114 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037000115 active site 391037000116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000117 non-specific DNA binding site [nucleotide binding]; other site 391037000118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037000119 salt bridge; other site 391037000120 sequence-specific DNA binding site [nucleotide binding]; other site 391037000121 Predicted ATPase [General function prediction only]; Region: COG3903 391037000122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000123 sequence-specific DNA binding site [nucleotide binding]; other site 391037000124 salt bridge; other site 391037000125 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037000126 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 391037000127 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 391037000128 calcium binding site 2 [ion binding]; other site 391037000129 active site 391037000130 catalytic triad [active] 391037000131 calcium binding site 1 [ion binding]; other site 391037000132 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 391037000133 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 391037000134 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 391037000135 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 391037000136 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 391037000137 NAD binding site [chemical binding]; other site 391037000138 homotetramer interface [polypeptide binding]; other site 391037000139 homodimer interface [polypeptide binding]; other site 391037000140 active site 391037000141 substrate binding site [chemical binding]; other site 391037000142 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 391037000143 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 391037000144 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 391037000145 phosphopeptide binding site; other site 391037000146 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 391037000147 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 391037000148 phosphopeptide binding site; other site 391037000149 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391037000150 active site 391037000151 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 391037000152 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 391037000153 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391037000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391037000155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037000156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037000157 active site 391037000158 ATP binding site [chemical binding]; other site 391037000159 substrate binding site [chemical binding]; other site 391037000160 activation loop (A-loop); other site 391037000161 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037000162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037000163 active site 391037000164 ATP binding site [chemical binding]; other site 391037000165 substrate binding site [chemical binding]; other site 391037000166 activation loop (A-loop); other site 391037000167 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037000168 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037000169 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037000170 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391037000171 Glutamine amidotransferase class-I; Region: GATase; pfam00117 391037000172 glutamine binding [chemical binding]; other site 391037000173 catalytic triad [active] 391037000174 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 391037000175 active site 391037000176 catalytic site [active] 391037000177 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 391037000178 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 391037000179 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 391037000180 4Fe-4S binding domain; Region: Fer4; pfam00037 391037000181 Cysteine-rich domain; Region: CCG; pfam02754 391037000182 Cysteine-rich domain; Region: CCG; pfam02754 391037000183 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391037000184 NlpC/P60 family; Region: NLPC_P60; pfam00877 391037000185 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391037000186 trimer interface [polypeptide binding]; other site 391037000187 active site 391037000188 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391037000189 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 391037000190 active site 391037000191 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391037000192 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 391037000193 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 391037000194 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 391037000195 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391037000196 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391037000197 homodimer interface [polypeptide binding]; other site 391037000198 NADP binding site [chemical binding]; other site 391037000199 substrate binding site [chemical binding]; other site 391037000200 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391037000201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391037000202 ligand binding site [chemical binding]; other site 391037000203 flexible hinge region; other site 391037000204 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391037000205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037000206 dimerization interface [polypeptide binding]; other site 391037000207 putative DNA binding site [nucleotide binding]; other site 391037000208 putative Zn2+ binding site [ion binding]; other site 391037000209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 391037000210 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 391037000211 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 391037000212 active site 391037000213 Zn binding site [ion binding]; other site 391037000214 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 391037000215 Peptidase family M28; Region: Peptidase_M28; pfam04389 391037000216 active site 391037000217 metal binding site [ion binding]; metal-binding site 391037000218 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 391037000219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037000220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037000221 active site 391037000222 phosphorylation site [posttranslational modification] 391037000223 intermolecular recognition site; other site 391037000224 dimerization interface [polypeptide binding]; other site 391037000225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037000226 DNA binding site [nucleotide binding] 391037000227 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391037000228 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 391037000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000231 RNA polymerase factor sigma-70; Validated; Region: PRK08241 391037000232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037000233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037000234 DNA binding residues [nucleotide binding] 391037000235 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037000236 putative acetyltransferase; Provisional; Region: PRK03624 391037000237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037000238 Coenzyme A binding pocket [chemical binding]; other site 391037000239 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 391037000240 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 391037000241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037000242 active site 391037000243 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 391037000244 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 391037000245 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391037000246 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391037000247 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391037000248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037000249 active site 391037000250 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391037000251 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 391037000252 catalytic core [active] 391037000253 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 391037000254 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391037000255 conserved cys residue [active] 391037000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037000257 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391037000258 conserved cys residue [active] 391037000259 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 391037000260 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 391037000261 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 391037000262 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391037000263 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391037000264 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 391037000265 putative active site [active] 391037000266 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391037000267 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037000268 NHL repeat; Region: NHL; pfam01436 391037000269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000270 non-specific DNA binding site [nucleotide binding]; other site 391037000271 salt bridge; other site 391037000272 sequence-specific DNA binding site [nucleotide binding]; other site 391037000273 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037000274 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391037000275 short chain dehydrogenase; Provisional; Region: PRK08303 391037000276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037000277 NAD(P) binding site [chemical binding]; other site 391037000278 active site 391037000279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000280 putative substrate translocation pore; other site 391037000281 tetracycline repressor protein TetR; Provisional; Region: PRK13756 391037000282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037000283 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 391037000284 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 391037000285 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037000286 E3 interaction surface; other site 391037000287 lipoyl attachment site [posttranslational modification]; other site 391037000288 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 391037000289 e3 binding domain; Region: E3_binding; pfam02817 391037000290 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391037000291 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391037000292 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391037000293 alpha subunit interface [polypeptide binding]; other site 391037000294 TPP binding site [chemical binding]; other site 391037000295 heterodimer interface [polypeptide binding]; other site 391037000296 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037000297 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 391037000298 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391037000299 TPP-binding site [chemical binding]; other site 391037000300 tetramer interface [polypeptide binding]; other site 391037000301 heterodimer interface [polypeptide binding]; other site 391037000302 phosphorylation loop region [posttranslational modification] 391037000303 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391037000304 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 391037000305 nucleotide binding site [chemical binding]; other site 391037000306 NEF interaction site [polypeptide binding]; other site 391037000307 SBD interface [polypeptide binding]; other site 391037000308 GrpE; Region: GrpE; pfam01025 391037000309 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 391037000310 dimer interface [polypeptide binding]; other site 391037000311 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391037000312 chaperone protein DnaJ; Provisional; Region: PRK14279 391037000313 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391037000314 HSP70 interaction site [polypeptide binding]; other site 391037000315 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391037000316 Zn binding sites [ion binding]; other site 391037000317 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391037000318 dimer interface [polypeptide binding]; other site 391037000319 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 391037000320 DNA binding residues [nucleotide binding] 391037000321 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037000322 putative dimer interface [polypeptide binding]; other site 391037000323 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391037000324 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 391037000325 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 391037000326 TrkA-C domain; Region: TrkA_C; pfam02080 391037000327 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391037000328 Clp amino terminal domain; Region: Clp_N; pfam02861 391037000329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037000330 Walker A motif; other site 391037000331 ATP binding site [chemical binding]; other site 391037000332 Walker B motif; other site 391037000333 arginine finger; other site 391037000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037000335 Walker A motif; other site 391037000336 ATP binding site [chemical binding]; other site 391037000337 Walker B motif; other site 391037000338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391037000339 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 391037000340 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 391037000341 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 391037000342 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 391037000343 spermidine synthase; Provisional; Region: PRK03612 391037000344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037000345 S-adenosylmethionine binding site [chemical binding]; other site 391037000346 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391037000347 classical (c) SDRs; Region: SDR_c; cd05233 391037000348 NAD(P) binding site [chemical binding]; other site 391037000349 active site 391037000350 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 391037000351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037000352 dimerization interface [polypeptide binding]; other site 391037000353 putative DNA binding site [nucleotide binding]; other site 391037000354 putative Zn2+ binding site [ion binding]; other site 391037000355 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391037000356 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 391037000357 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 391037000358 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 391037000359 active site 391037000360 intersubunit interface [polypeptide binding]; other site 391037000361 zinc binding site [ion binding]; other site 391037000362 Na+ binding site [ion binding]; other site 391037000363 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 391037000364 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 391037000365 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391037000366 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391037000367 GDP-binding site [chemical binding]; other site 391037000368 ACT binding site; other site 391037000369 IMP binding site; other site 391037000370 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391037000371 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391037000372 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 391037000373 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391037000374 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037000375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037000376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037000377 active site 391037000378 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391037000379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037000380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037000381 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391037000382 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391037000383 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037000384 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037000385 active site 1 [active] 391037000386 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 391037000387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037000388 NAD(P) binding site [chemical binding]; other site 391037000389 active site 391037000390 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 391037000391 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037000392 dimer interface [polypeptide binding]; other site 391037000393 active site 391037000394 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 391037000395 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037000396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037000397 DNA-binding site [nucleotide binding]; DNA binding site 391037000398 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 391037000399 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 391037000400 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 391037000401 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391037000402 active site 391037000403 HIGH motif; other site 391037000404 KMSK motif region; other site 391037000405 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 391037000406 tRNA binding surface [nucleotide binding]; other site 391037000407 anticodon binding site; other site 391037000408 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 391037000409 adenylosuccinate lyase; Region: purB; TIGR00928 391037000410 tetramer interface [polypeptide binding]; other site 391037000411 Uncharacterized conserved protein [Function unknown]; Region: COG0393 391037000412 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391037000413 cleavage site 391037000414 active site 391037000415 substrate binding sites [chemical binding]; other site 391037000416 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 391037000417 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 391037000418 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391037000419 putative active site [active] 391037000420 catalytic triad [active] 391037000421 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 391037000422 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 391037000423 dimerization interface [polypeptide binding]; other site 391037000424 ATP binding site [chemical binding]; other site 391037000425 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 391037000426 dimerization interface [polypeptide binding]; other site 391037000427 ATP binding site [chemical binding]; other site 391037000428 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 391037000429 Cna protein B-type domain; Region: Cna_B_2; pfam13715 391037000430 SCP-2 sterol transfer family; Region: SCP2; cl01225 391037000431 amidophosphoribosyltransferase; Provisional; Region: PRK07847 391037000432 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391037000433 active site 391037000434 tetramer interface [polypeptide binding]; other site 391037000435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037000436 active site 391037000437 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391037000438 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 391037000439 dimerization interface [polypeptide binding]; other site 391037000440 putative ATP binding site [chemical binding]; other site 391037000441 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 391037000442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037000443 FeS/SAM binding site; other site 391037000444 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 391037000445 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 391037000446 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391037000447 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391037000448 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 391037000449 NAD binding site [chemical binding]; other site 391037000450 Phe binding site; other site 391037000451 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 391037000452 DNA binding residues [nucleotide binding] 391037000453 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 391037000454 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 391037000455 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037000456 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391037000457 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391037000458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037000459 substrate binding site [chemical binding]; other site 391037000460 oxyanion hole (OAH) forming residues; other site 391037000461 trimer interface [polypeptide binding]; other site 391037000462 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391037000463 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391037000464 ligand binding site [chemical binding]; other site 391037000465 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 391037000466 putative hydrophobic ligand binding site [chemical binding]; other site 391037000467 CLM binding site; other site 391037000468 L1 loop; other site 391037000469 DNA binding site [nucleotide binding] 391037000470 MarR family; Region: MarR_2; pfam12802 391037000471 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037000472 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037000473 homodimer interface [polypeptide binding]; other site 391037000474 active site 391037000475 TDP-binding site; other site 391037000476 acceptor substrate-binding pocket; other site 391037000477 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391037000478 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391037000479 dimerization interface [polypeptide binding]; other site 391037000480 ligand binding site [chemical binding]; other site 391037000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037000482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037000484 non-specific DNA binding site [nucleotide binding]; other site 391037000485 sequence-specific DNA binding site [nucleotide binding]; other site 391037000486 salt bridge; other site 391037000487 CAAX protease self-immunity; Region: Abi; pfam02517 391037000488 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391037000489 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 391037000490 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391037000491 Thioredoxin; Region: Thioredoxin_4; cl17273 391037000492 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 391037000493 putative active site [active] 391037000494 redox center [active] 391037000495 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 391037000496 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 391037000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000498 putative substrate translocation pore; other site 391037000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000500 putative substrate translocation pore; other site 391037000501 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 391037000502 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 391037000503 [4Fe-4S] binding site [ion binding]; other site 391037000504 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037000505 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037000506 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037000507 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 391037000508 molybdopterin cofactor binding site; other site 391037000509 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 391037000510 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 391037000511 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 391037000512 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 391037000513 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 391037000514 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391037000515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037000516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037000517 S-adenosylmethionine binding site [chemical binding]; other site 391037000518 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391037000519 Ligand binding site; other site 391037000520 metal-binding site 391037000521 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391037000522 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391037000523 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391037000524 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391037000525 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391037000526 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391037000527 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391037000528 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391037000529 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391037000530 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037000531 catalytic loop [active] 391037000532 iron binding site [ion binding]; other site 391037000533 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391037000534 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 391037000535 VanW like protein; Region: VanW; pfam04294 391037000536 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 391037000537 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 391037000538 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391037000539 putative NADH binding site [chemical binding]; other site 391037000540 putative active site [active] 391037000541 nudix motif; other site 391037000542 putative metal binding site [ion binding]; other site 391037000543 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 391037000544 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037000545 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037000546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037000547 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391037000548 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 391037000549 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391037000550 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391037000551 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 391037000552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391037000553 HlyD family secretion protein; Region: HlyD_3; pfam13437 391037000554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037000556 active site 391037000557 phosphorylation site [posttranslational modification] 391037000558 intermolecular recognition site; other site 391037000559 dimerization interface [polypeptide binding]; other site 391037000560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037000561 DNA binding site [nucleotide binding] 391037000562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037000563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037000564 dimerization interface [polypeptide binding]; other site 391037000565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037000566 dimer interface [polypeptide binding]; other site 391037000567 phosphorylation site [posttranslational modification] 391037000568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037000569 ATP binding site [chemical binding]; other site 391037000570 Mg2+ binding site [ion binding]; other site 391037000571 G-X-G motif; other site 391037000572 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391037000573 HlyD family secretion protein; Region: HlyD_3; pfam13437 391037000574 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391037000575 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391037000576 Walker A/P-loop; other site 391037000577 ATP binding site [chemical binding]; other site 391037000578 Q-loop/lid; other site 391037000579 ABC transporter signature motif; other site 391037000580 Walker B; other site 391037000581 D-loop; other site 391037000582 H-loop/switch region; other site 391037000583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391037000584 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391037000585 FtsX-like permease family; Region: FtsX; pfam02687 391037000586 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391037000587 EamA-like transporter family; Region: EamA; pfam00892 391037000588 EamA-like transporter family; Region: EamA; pfam00892 391037000589 hypothetical protein; Provisional; Region: PRK07945 391037000590 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 391037000591 active site 391037000592 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037000593 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 391037000594 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391037000595 nucleoside/Zn binding site; other site 391037000596 dimer interface [polypeptide binding]; other site 391037000597 catalytic motif [active] 391037000598 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 391037000599 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 391037000600 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037000601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037000602 S-adenosylmethionine binding site [chemical binding]; other site 391037000603 hypothetical protein; Provisional; Region: PRK11770 391037000604 Domain of unknown function (DUF307); Region: DUF307; pfam03733 391037000605 Domain of unknown function (DUF307); Region: DUF307; pfam03733 391037000606 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037000607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037000608 S-adenosylmethionine binding site [chemical binding]; other site 391037000609 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391037000610 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 391037000611 NAD(P) binding site [chemical binding]; other site 391037000612 catalytic residues [active] 391037000613 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391037000614 putative hydrophobic ligand binding site [chemical binding]; other site 391037000615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037000616 putative DNA binding site [nucleotide binding]; other site 391037000617 dimerization interface [polypeptide binding]; other site 391037000618 putative Zn2+ binding site [ion binding]; other site 391037000619 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 391037000620 putative hydrophobic ligand binding site [chemical binding]; other site 391037000621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 391037000622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037000623 non-specific DNA binding site [nucleotide binding]; other site 391037000624 salt bridge; other site 391037000625 sequence-specific DNA binding site [nucleotide binding]; other site 391037000626 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 391037000627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037000628 Walker A motif; other site 391037000629 ATP binding site [chemical binding]; other site 391037000630 Walker B motif; other site 391037000631 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391037000632 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 391037000633 recombination protein RecR; Reviewed; Region: recR; PRK00076 391037000634 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 391037000635 RecR protein; Region: RecR; pfam02132 391037000636 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391037000637 putative active site [active] 391037000638 putative metal-binding site [ion binding]; other site 391037000639 tetramer interface [polypeptide binding]; other site 391037000640 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391037000641 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 391037000642 peptide binding site [polypeptide binding]; other site 391037000643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037000645 dimer interface [polypeptide binding]; other site 391037000646 conserved gate region; other site 391037000647 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 391037000648 ABC-ATPase subunit interface; other site 391037000649 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391037000650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391037000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037000652 putative PBP binding loops; other site 391037000653 dimer interface [polypeptide binding]; other site 391037000654 ABC-ATPase subunit interface; other site 391037000655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391037000656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037000657 Walker A/P-loop; other site 391037000658 ATP binding site [chemical binding]; other site 391037000659 Q-loop/lid; other site 391037000660 ABC transporter signature motif; other site 391037000661 Walker B; other site 391037000662 D-loop; other site 391037000663 H-loop/switch region; other site 391037000664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391037000665 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391037000666 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037000667 Walker A/P-loop; other site 391037000668 ATP binding site [chemical binding]; other site 391037000669 Q-loop/lid; other site 391037000670 ABC transporter signature motif; other site 391037000671 Walker B; other site 391037000672 D-loop; other site 391037000673 H-loop/switch region; other site 391037000674 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391037000675 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 391037000676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037000677 putative substrate translocation pore; other site 391037000678 2-isopropylmalate synthase; Validated; Region: PRK03739 391037000679 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 391037000680 active site 391037000681 catalytic residues [active] 391037000682 metal binding site [ion binding]; metal-binding site 391037000683 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391037000684 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 391037000685 putative FMN binding site [chemical binding]; other site 391037000686 aspartate kinase; Reviewed; Region: PRK06635 391037000687 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391037000688 putative nucleotide binding site [chemical binding]; other site 391037000689 putative catalytic residues [active] 391037000690 putative Mg ion binding site [ion binding]; other site 391037000691 putative aspartate binding site [chemical binding]; other site 391037000692 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391037000693 putative allosteric regulatory site; other site 391037000694 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391037000695 putative allosteric regulatory residue; other site 391037000696 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391037000697 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391037000698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037000699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037000700 metal binding site [ion binding]; metal-binding site 391037000701 active site 391037000702 I-site; other site 391037000703 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391037000704 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 391037000705 putative active site [active] 391037000706 putative metal binding site [ion binding]; other site 391037000707 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391037000708 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 391037000709 AAA domain; Region: AAA_30; pfam13604 391037000710 Family description; Region: UvrD_C_2; pfam13538 391037000711 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 391037000712 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 391037000713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037000714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037000715 DNA binding residues [nucleotide binding] 391037000716 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 391037000717 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 391037000718 Cupin domain; Region: Cupin_2; cl17218 391037000719 Predicted transcriptional regulator [Transcription]; Region: COG2345 391037000720 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391037000721 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391037000722 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391037000723 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 391037000724 active site 391037000725 homodimer interface [polypeptide binding]; other site 391037000726 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391037000727 enoyl-CoA hydratase; Provisional; Region: PRK06127 391037000728 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037000729 substrate binding site [chemical binding]; other site 391037000730 oxyanion hole (OAH) forming residues; other site 391037000731 trimer interface [polypeptide binding]; other site 391037000732 Uncharacterized conserved protein [Function unknown]; Region: COG3349 391037000733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037000734 TrkA-N domain; Region: TrkA_N; pfam02254 391037000735 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391037000736 TrkA-N domain; Region: TrkA_N; pfam02254 391037000737 TrkA-C domain; Region: TrkA_C; pfam02080 391037000738 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 391037000739 active site 391037000740 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 391037000741 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 391037000742 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 391037000743 active site 391037000744 dimer interface [polypeptide binding]; other site 391037000745 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037000746 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391037000747 nucleotide binding site [chemical binding]; other site 391037000748 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391037000749 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 391037000750 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391037000751 dimer interface [polypeptide binding]; other site 391037000752 active site 391037000753 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 391037000754 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 391037000755 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391037000756 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 391037000757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037000758 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037000759 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 391037000760 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 391037000761 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 391037000762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037000763 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391037000764 Walker A motif; other site 391037000765 ATP binding site [chemical binding]; other site 391037000766 Walker B motif; other site 391037000767 arginine finger; other site 391037000768 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037000769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037000770 S-adenosylmethionine binding site [chemical binding]; other site 391037000771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037000772 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391037000773 NAD(P) binding site [chemical binding]; other site 391037000774 active site 391037000775 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037000776 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 391037000777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037000778 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 391037000779 Walker A/P-loop; other site 391037000780 ATP binding site [chemical binding]; other site 391037000781 Q-loop/lid; other site 391037000782 ABC transporter signature motif; other site 391037000783 Walker B; other site 391037000784 D-loop; other site 391037000785 H-loop/switch region; other site 391037000786 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 391037000787 DivIVA domain; Region: DivI1A_domain; TIGR03544 391037000788 threonine synthase; Validated; Region: PRK07591 391037000789 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 391037000790 homodimer interface [polypeptide binding]; other site 391037000791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037000792 catalytic residue [active] 391037000793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037000794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037000795 Coenzyme A binding pocket [chemical binding]; other site 391037000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037000797 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 391037000798 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037000799 NAD(P) binding site [chemical binding]; other site 391037000800 catalytic residues [active] 391037000801 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037000802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037000803 S-adenosylmethionine binding site [chemical binding]; other site 391037000804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037000805 Coenzyme A binding pocket [chemical binding]; other site 391037000806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037000807 DNA-binding site [nucleotide binding]; DNA binding site 391037000808 RNA-binding motif; other site 391037000809 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391037000810 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391037000811 ring oligomerisation interface [polypeptide binding]; other site 391037000812 ATP/Mg binding site [chemical binding]; other site 391037000813 stacking interactions; other site 391037000814 hinge regions; other site 391037000815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037000816 Coenzyme A binding pocket [chemical binding]; other site 391037000817 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037000818 active site 391037000819 catalytic residues [active] 391037000820 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391037000821 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037000822 FAD binding domain; Region: FAD_binding_4; pfam01565 391037000823 Predicted membrane protein [Function unknown]; Region: COG4129 391037000824 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 391037000825 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037000826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037000827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037000828 catalytic residue [active] 391037000829 Protease prsW family; Region: PrsW-protease; pfam13367 391037000830 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391037000831 oligomerisation interface [polypeptide binding]; other site 391037000832 mobile loop; other site 391037000833 roof hairpin; other site 391037000834 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391037000835 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391037000836 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 391037000837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037000838 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 391037000839 Protein of unknown function (DUF402); Region: DUF402; cl00979 391037000840 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 391037000841 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 391037000842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037000843 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037000844 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 391037000845 PhoU domain; Region: PhoU; pfam01895 391037000846 PhoU domain; Region: PhoU; pfam01895 391037000847 PBP superfamily domain; Region: PBP_like_2; cl17296 391037000848 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 391037000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037000850 dimer interface [polypeptide binding]; other site 391037000851 conserved gate region; other site 391037000852 putative PBP binding loops; other site 391037000853 ABC-ATPase subunit interface; other site 391037000854 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 391037000855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037000856 dimer interface [polypeptide binding]; other site 391037000857 conserved gate region; other site 391037000858 putative PBP binding loops; other site 391037000859 ABC-ATPase subunit interface; other site 391037000860 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 391037000861 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 391037000862 Walker A/P-loop; other site 391037000863 ATP binding site [chemical binding]; other site 391037000864 Q-loop/lid; other site 391037000865 ABC transporter signature motif; other site 391037000866 Walker B; other site 391037000867 D-loop; other site 391037000868 H-loop/switch region; other site 391037000869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037000870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037000871 DNA binding site [nucleotide binding] 391037000872 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 391037000873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037000874 Coenzyme A binding pocket [chemical binding]; other site 391037000875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037000876 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 391037000877 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391037000878 NodB motif; other site 391037000879 active site 391037000880 catalytic site [active] 391037000881 metal binding site [ion binding]; metal-binding site 391037000882 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037000883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037000884 DNA binding site [nucleotide binding] 391037000885 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 391037000886 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391037000887 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391037000888 active site residue [active] 391037000889 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391037000890 active site residue [active] 391037000891 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 391037000892 DivIVA domain; Region: DivI1A_domain; TIGR03544 391037000893 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037000894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037000895 DNA-binding site [nucleotide binding]; DNA binding site 391037000896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037000897 DNA-binding site [nucleotide binding]; DNA binding site 391037000898 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391037000899 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 391037000900 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 391037000901 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 391037000902 AAA ATPase domain; Region: AAA_16; pfam13191 391037000903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037000904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037000905 DNA binding residues [nucleotide binding] 391037000906 dimerization interface [polypeptide binding]; other site 391037000907 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 391037000908 active site 391037000909 zinc binding site [ion binding]; other site 391037000910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037000911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037000912 DNA binding residues [nucleotide binding] 391037000913 dimerization interface [polypeptide binding]; other site 391037000914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037000915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037000916 dimerization interface [polypeptide binding]; other site 391037000917 DNA binding residues [nucleotide binding] 391037000918 MbtH-like protein; Region: MbtH; cl01279 391037000919 Condensation domain; Region: Condensation; pfam00668 391037000920 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037000921 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037000922 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 391037000923 acyl-activating enzyme (AAE) consensus motif; other site 391037000924 AMP binding site [chemical binding]; other site 391037000925 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037000926 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 391037000927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037000928 inhibitor-cofactor binding pocket; inhibition site 391037000929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037000930 catalytic residue [active] 391037000931 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 391037000932 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391037000933 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391037000934 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037000935 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037000936 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037000937 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037000938 acyl-activating enzyme (AAE) consensus motif; other site 391037000939 AMP binding site [chemical binding]; other site 391037000940 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391037000941 serine racemase; Region: PLN02970 391037000942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037000943 catalytic residue [active] 391037000944 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037000945 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037000946 aspartate kinase; Reviewed; Region: PRK06635 391037000947 Condensation domain; Region: Condensation; pfam00668 391037000948 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037000949 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037000950 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037000951 acyl-activating enzyme (AAE) consensus motif; other site 391037000952 AMP binding site [chemical binding]; other site 391037000953 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037000954 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 391037000955 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037000956 acyl-activating enzyme (AAE) consensus motif; other site 391037000957 AMP binding site [chemical binding]; other site 391037000958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037000959 Thioesterase domain; Region: Thioesterase; pfam00975 391037000960 Condensation domain; Region: Condensation; pfam00668 391037000961 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037000962 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037000963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037000964 acyl-activating enzyme (AAE) consensus motif; other site 391037000965 AMP binding site [chemical binding]; other site 391037000966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037000967 Condensation domain; Region: Condensation; pfam00668 391037000968 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037000969 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037000970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037000971 acyl-activating enzyme (AAE) consensus motif; other site 391037000972 AMP binding site [chemical binding]; other site 391037000973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037000974 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 391037000975 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037000976 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 391037000977 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391037000978 dimer interface [polypeptide binding]; other site 391037000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037000980 catalytic residue [active] 391037000981 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 391037000982 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391037000983 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 391037000984 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 391037000985 active site 391037000986 catalytic triad [active] 391037000987 Cna protein B-type domain; Region: Cna_B_2; pfam13715 391037000988 Kelch domain; Region: Kelch; smart00612 391037000989 Kelch motif; Region: Kelch_1; pfam01344 391037000990 Kelch motif; Region: Kelch_1; pfam01344 391037000991 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 391037000992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037000993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037000994 DNA binding site [nucleotide binding] 391037000995 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 391037000996 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 391037000997 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 391037000998 heme-binding site [chemical binding]; other site 391037000999 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 391037001000 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391037001001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037001002 catalytic residue [active] 391037001003 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391037001004 metal binding site 2 [ion binding]; metal-binding site 391037001005 putative DNA binding helix; other site 391037001006 metal binding site 1 [ion binding]; metal-binding site 391037001007 dimer interface [polypeptide binding]; other site 391037001008 structural Zn2+ binding site [ion binding]; other site 391037001009 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 391037001010 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391037001011 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391037001012 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391037001013 L-asparaginase II; Region: Asparaginase_II; pfam06089 391037001014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037001015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037001016 non-specific DNA binding site [nucleotide binding]; other site 391037001017 salt bridge; other site 391037001018 sequence-specific DNA binding site [nucleotide binding]; other site 391037001019 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 391037001020 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391037001021 Protein of unknown function (DUF2454); Region: DUF2454; pfam10521 391037001022 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 391037001023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037001024 Coenzyme A binding pocket [chemical binding]; other site 391037001025 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391037001026 homotrimer interaction site [polypeptide binding]; other site 391037001027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037001028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037001029 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 391037001030 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391037001031 NADP binding site [chemical binding]; other site 391037001032 active site 391037001033 regulatory binding site [polypeptide binding]; other site 391037001034 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037001035 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037001036 DNA binding site [nucleotide binding] 391037001037 domain linker motif; other site 391037001038 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 391037001039 putative dimerization interface [polypeptide binding]; other site 391037001040 putative ligand binding site [chemical binding]; other site 391037001041 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391037001042 beta-galactosidase; Region: BGL; TIGR03356 391037001043 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037001044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037001045 dimer interface [polypeptide binding]; other site 391037001046 conserved gate region; other site 391037001047 putative PBP binding loops; other site 391037001048 ABC-ATPase subunit interface; other site 391037001049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391037001050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037001051 dimer interface [polypeptide binding]; other site 391037001052 ABC-ATPase subunit interface; other site 391037001053 putative PBP binding loops; other site 391037001054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037001055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037001056 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 391037001057 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 391037001058 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 391037001059 FAD binding domain; Region: FAD_binding_4; pfam01565 391037001060 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391037001061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001062 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391037001063 NAD(P) binding site [chemical binding]; other site 391037001064 active site 391037001065 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 391037001066 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 391037001067 putative ADP-binding pocket [chemical binding]; other site 391037001068 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 391037001069 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 391037001070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037001071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037001072 putative substrate translocation pore; other site 391037001073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037001074 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037001075 catalytic core [active] 391037001076 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037001077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037001078 dimer interface [polypeptide binding]; other site 391037001079 phosphorylation site [posttranslational modification] 391037001080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037001081 ATP binding site [chemical binding]; other site 391037001082 Mg2+ binding site [ion binding]; other site 391037001083 G-X-G motif; other site 391037001084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037001085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037001086 active site 391037001087 phosphorylation site [posttranslational modification] 391037001088 intermolecular recognition site; other site 391037001089 dimerization interface [polypeptide binding]; other site 391037001090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037001091 DNA binding site [nucleotide binding] 391037001092 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391037001093 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391037001094 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391037001095 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391037001096 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 391037001097 Metal-binding active site; metal-binding site 391037001098 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 391037001099 CGNR zinc finger; Region: zf-CGNR; pfam11706 391037001100 Proline dehydrogenase; Region: Pro_dh; cl03282 391037001101 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037001102 HlyD family secretion protein; Region: HlyD_3; pfam13437 391037001103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391037001104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391037001105 Walker A/P-loop; other site 391037001106 ATP binding site [chemical binding]; other site 391037001107 Q-loop/lid; other site 391037001108 ABC transporter signature motif; other site 391037001109 Walker B; other site 391037001110 D-loop; other site 391037001111 H-loop/switch region; other site 391037001112 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391037001113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391037001114 FtsX-like permease family; Region: FtsX; pfam02687 391037001115 DNA binding domain, excisionase family; Region: excise; TIGR01764 391037001116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001117 NAD(P) binding site [chemical binding]; other site 391037001118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037001119 active site 391037001120 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037001121 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 391037001122 putative acyl-acceptor binding pocket; other site 391037001123 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037001125 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391037001126 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391037001127 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 391037001128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037001129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037001130 DNA binding residues [nucleotide binding] 391037001131 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 391037001132 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391037001133 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391037001134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037001135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037001136 phosphorylation site [posttranslational modification] 391037001137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037001138 DNA binding residues [nucleotide binding] 391037001139 dimerization interface [polypeptide binding]; other site 391037001140 Putative sensor; Region: Sensor; pfam13796 391037001141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037001142 Histidine kinase; Region: HisKA_3; pfam07730 391037001143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037001144 ATP binding site [chemical binding]; other site 391037001145 Mg2+ binding site [ion binding]; other site 391037001146 G-X-G motif; other site 391037001147 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 391037001148 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 391037001149 CoA binding domain; Region: CoA_binding; pfam02629 391037001150 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 391037001151 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 391037001152 tRNA; other site 391037001153 putative tRNA binding site [nucleotide binding]; other site 391037001154 putative NADP binding site [chemical binding]; other site 391037001155 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 391037001156 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391037001157 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 391037001158 domain interfaces; other site 391037001159 active site 391037001160 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 391037001161 active site 391037001162 homodimer interface [polypeptide binding]; other site 391037001163 SAM binding site [chemical binding]; other site 391037001164 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 391037001165 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391037001166 active site 391037001167 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 391037001168 dimer interface [polypeptide binding]; other site 391037001169 active site 391037001170 Schiff base residues; other site 391037001171 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 391037001172 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 391037001173 generic binding surface I; other site 391037001174 generic binding surface II; other site 391037001175 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037001176 putative catalytic site [active] 391037001177 putative phosphate binding site [ion binding]; other site 391037001178 putative metal binding site [ion binding]; other site 391037001179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037001180 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391037001181 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391037001182 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 391037001183 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391037001184 cyclase homology domain; Region: CHD; cd07302 391037001185 nucleotidyl binding site; other site 391037001186 metal binding site [ion binding]; metal-binding site 391037001187 dimer interface [polypeptide binding]; other site 391037001188 AAA ATPase domain; Region: AAA_16; pfam13191 391037001189 Predicted ATPase [General function prediction only]; Region: COG3903 391037001190 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037001191 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391037001192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037001193 binding surface 391037001194 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391037001195 TPR motif; other site 391037001196 Smr domain; Region: Smr; pfam01713 391037001197 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 391037001198 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391037001199 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 391037001200 active site 391037001201 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 391037001202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037001203 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391037001204 TrkA-N domain; Region: TrkA_N; pfam02254 391037001205 TrkA-C domain; Region: TrkA_C; pfam02080 391037001206 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391037001207 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391037001208 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391037001209 classical (c) SDRs; Region: SDR_c; cd05233 391037001210 NAD(P) binding site [chemical binding]; other site 391037001211 active site 391037001212 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391037001213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037001214 ATP binding site [chemical binding]; other site 391037001215 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391037001216 putative Mg++ binding site [ion binding]; other site 391037001217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037001218 nucleotide binding region [chemical binding]; other site 391037001219 ATP-binding site [chemical binding]; other site 391037001220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037001221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037001222 non-specific DNA binding site [nucleotide binding]; other site 391037001223 salt bridge; other site 391037001224 sequence-specific DNA binding site [nucleotide binding]; other site 391037001225 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037001226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001227 S-adenosylmethionine binding site [chemical binding]; other site 391037001228 helicase 45; Provisional; Region: PTZ00424 391037001229 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391037001230 ATP binding site [chemical binding]; other site 391037001231 Mg++ binding site [ion binding]; other site 391037001232 motif III; other site 391037001233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037001234 nucleotide binding region [chemical binding]; other site 391037001235 ATP-binding site [chemical binding]; other site 391037001236 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 391037001237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037001238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037001239 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 391037001240 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391037001241 ATP binding site [chemical binding]; other site 391037001242 substrate interface [chemical binding]; other site 391037001243 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037001244 active site residue [active] 391037001245 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 391037001246 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391037001247 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391037001248 putative catalytic cysteine [active] 391037001249 gamma-glutamyl kinase; Provisional; Region: PRK05429 391037001250 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391037001251 nucleotide binding site [chemical binding]; other site 391037001252 homotetrameric interface [polypeptide binding]; other site 391037001253 putative phosphate binding site [ion binding]; other site 391037001254 putative allosteric binding site; other site 391037001255 PUA domain; Region: PUA; pfam01472 391037001256 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391037001257 active site 391037001258 DNA binding site [nucleotide binding] 391037001259 MFS/sugar transport protein; Region: MFS_2; pfam13347 391037001260 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 391037001261 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 391037001262 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 391037001263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037001264 catalytic residue [active] 391037001265 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391037001266 Glucose dehydrogenase; Region: glucose_DH; cd08230 391037001267 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391037001268 NADP binding site [chemical binding]; other site 391037001269 catalytic Zn binding site [ion binding]; other site 391037001270 structural Zn binding site [ion binding]; other site 391037001271 dimer interface [polypeptide binding]; other site 391037001272 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 391037001273 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 391037001274 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391037001275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037001276 Coenzyme A binding pocket [chemical binding]; other site 391037001277 Predicted permeases [General function prediction only]; Region: RarD; COG2962 391037001278 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391037001279 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391037001280 putative dimer interface [polypeptide binding]; other site 391037001281 N-terminal domain interface [polypeptide binding]; other site 391037001282 putative substrate binding pocket (H-site) [chemical binding]; other site 391037001283 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 391037001284 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391037001285 4Fe-4S binding domain; Region: Fer4; pfam00037 391037001286 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 391037001287 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391037001288 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 391037001289 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 391037001290 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001291 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001292 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001293 heat shock protein HtpX; Provisional; Region: PRK03072 391037001294 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 391037001295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001296 NAD(P) binding site [chemical binding]; other site 391037001297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 391037001298 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 391037001299 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391037001300 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 391037001301 DNA binding residues [nucleotide binding] 391037001302 drug binding residues [chemical binding]; other site 391037001303 dimer interface [polypeptide binding]; other site 391037001304 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 391037001305 beta-clamp/clamp loader binding surface; other site 391037001306 beta-clamp/translesion DNA polymerase binding surface; other site 391037001307 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391037001308 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391037001309 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391037001310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037001311 active site 391037001312 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391037001313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 391037001314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037001315 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 391037001316 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037001317 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391037001318 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037001319 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 391037001320 active site 391037001321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037001322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 391037001323 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 391037001324 dimer interface [polypeptide binding]; other site 391037001325 active site 391037001326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037001327 catalytic residues [active] 391037001328 substrate binding site [chemical binding]; other site 391037001329 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 391037001330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037001331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037001332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037001333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037001334 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391037001335 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391037001336 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037001337 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 391037001338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037001339 AMP-binding enzyme; Region: AMP-binding; pfam00501 391037001340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037001341 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 391037001342 acyl-activating enzyme (AAE) consensus motif; other site 391037001343 acyl-activating enzyme (AAE) consensus motif; other site 391037001344 AMP binding site [chemical binding]; other site 391037001345 active site 391037001346 CoA binding site [chemical binding]; other site 391037001347 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 391037001348 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 391037001349 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391037001350 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 391037001351 active site 391037001352 substrate binding site [chemical binding]; other site 391037001353 FMN binding site [chemical binding]; other site 391037001354 putative catalytic residues [active] 391037001355 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391037001356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391037001357 active site 391037001358 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 391037001359 hypothetical protein; Provisional; Region: PRK08236 391037001360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037001361 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 391037001362 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 391037001363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037001364 MarR family; Region: MarR; pfam01047 391037001365 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037001367 putative substrate translocation pore; other site 391037001368 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 391037001369 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 391037001370 phosphoserine aminotransferase; Provisional; Region: PRK03080 391037001371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037001372 catalytic residue [active] 391037001373 citrate synthase 2; Provisional; Region: PRK12350 391037001374 Citrate synthase; Region: Citrate_synt; pfam00285 391037001375 oxalacetate binding site [chemical binding]; other site 391037001376 citrylCoA binding site [chemical binding]; other site 391037001377 coenzyme A binding site [chemical binding]; other site 391037001378 catalytic triad [active] 391037001379 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391037001380 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 391037001381 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391037001382 enterobactin exporter EntS; Provisional; Region: PRK10489 391037001383 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 391037001384 active site 391037001385 catalytic residues [active] 391037001386 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 391037001387 FMN binding site [chemical binding]; other site 391037001388 dimer interface [polypeptide binding]; other site 391037001389 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 391037001390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037001391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037001392 active site 391037001393 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391037001394 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391037001395 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 391037001396 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391037001397 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037001398 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 391037001399 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 391037001400 Walker A/P-loop; other site 391037001401 ATP binding site [chemical binding]; other site 391037001402 Q-loop/lid; other site 391037001403 ABC transporter signature motif; other site 391037001404 Walker B; other site 391037001405 D-loop; other site 391037001406 H-loop/switch region; other site 391037001407 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391037001408 putative glycosyl transferase; Provisional; Region: PRK10073 391037001409 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391037001410 active site 391037001411 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 391037001412 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 391037001413 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391037001414 CoenzymeA binding site [chemical binding]; other site 391037001415 subunit interaction site [polypeptide binding]; other site 391037001416 PHB binding site; other site 391037001417 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 391037001418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037001419 motif II; other site 391037001420 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 391037001421 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 391037001422 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 391037001423 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 391037001424 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037001425 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 391037001426 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 391037001427 putative active site [active] 391037001428 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 391037001429 active site clefts [active] 391037001430 zinc binding site [ion binding]; other site 391037001431 dimer interface [polypeptide binding]; other site 391037001432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 391037001433 YibE/F-like protein; Region: YibE_F; pfam07907 391037001434 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 391037001435 putative homodimer interface [polypeptide binding]; other site 391037001436 putative homotetramer interface [polypeptide binding]; other site 391037001437 putative allosteric switch controlling residues; other site 391037001438 putative metal binding site [ion binding]; other site 391037001439 putative homodimer-homodimer interface [polypeptide binding]; other site 391037001440 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391037001441 metal-binding site [ion binding] 391037001442 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391037001443 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391037001444 metal-binding site [ion binding] 391037001445 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391037001446 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 391037001447 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391037001448 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 391037001449 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 391037001450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001451 S-adenosylmethionine binding site [chemical binding]; other site 391037001452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001453 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 391037001454 proline aminopeptidase P II; Provisional; Region: PRK10879 391037001455 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 391037001456 active site 391037001457 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391037001458 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391037001459 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 391037001460 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391037001461 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 391037001462 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 391037001463 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 391037001464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037001465 active site 391037001466 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037001467 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037001468 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 391037001469 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037001470 putative NADP binding site [chemical binding]; other site 391037001471 active site 391037001472 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037001473 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037001474 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391037001475 active site 391037001476 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391037001477 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037001478 Cytochrome P450; Region: p450; cl12078 391037001479 Family description; Region: VCBS; pfam13517 391037001480 Family description; Region: VCBS; pfam13517 391037001481 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 391037001482 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391037001483 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037001484 DNA binding residues [nucleotide binding] 391037001485 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391037001486 TIGR03084 family protein; Region: TIGR03084 391037001487 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 391037001488 Wyosine base formation; Region: Wyosine_form; pfam08608 391037001489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037001490 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037001491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037001492 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391037001493 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 391037001494 FMN binding site [chemical binding]; other site 391037001495 active site 391037001496 substrate binding site [chemical binding]; other site 391037001497 catalytic residue [active] 391037001498 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391037001499 ATP binding site [chemical binding]; other site 391037001500 substrate binding site [chemical binding]; other site 391037001501 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391037001502 purine monophosphate binding site [chemical binding]; other site 391037001503 dimer interface [polypeptide binding]; other site 391037001504 putative catalytic residues [active] 391037001505 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391037001506 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391037001507 GDP-binding site [chemical binding]; other site 391037001508 ACT binding site; other site 391037001509 IMP binding site; other site 391037001510 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391037001511 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391037001512 ligand binding site [chemical binding]; other site 391037001513 NAD binding site [chemical binding]; other site 391037001514 dimerization interface [polypeptide binding]; other site 391037001515 catalytic site [active] 391037001516 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391037001517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037001518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037001519 DNA binding residues [nucleotide binding] 391037001520 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 391037001521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037001522 inhibitor-cofactor binding pocket; inhibition site 391037001523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037001524 catalytic residue [active] 391037001525 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 391037001526 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 391037001527 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037001528 active site 391037001529 nucleotide binding site [chemical binding]; other site 391037001530 HIGH motif; other site 391037001531 KMSKS motif; other site 391037001532 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 391037001533 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 391037001534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037001535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037001536 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 391037001537 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 391037001538 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391037001539 iron-sulfur cluster [ion binding]; other site 391037001540 [2Fe-2S] cluster binding site [ion binding]; other site 391037001541 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391037001542 hydrophobic ligand binding site; other site 391037001543 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 391037001544 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391037001545 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391037001546 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391037001547 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037001548 Amidohydrolase; Region: Amidohydro_4; pfam13147 391037001549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037001550 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 391037001551 ATP binding site [chemical binding]; other site 391037001552 active site 391037001553 substrate binding site [chemical binding]; other site 391037001554 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 391037001555 adenylosuccinate lyase; Region: purB; TIGR00928 391037001556 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 391037001557 tetramer interface [polypeptide binding]; other site 391037001558 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 391037001559 nudix motif; other site 391037001560 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cd00476 391037001561 ATP binding site [chemical binding]; other site 391037001562 active site 391037001563 substrate binding site [chemical binding]; other site 391037001564 short chain dehydrogenase; Provisional; Region: PRK07326 391037001565 classical (c) SDRs; Region: SDR_c; cd05233 391037001566 NAD(P) binding site [chemical binding]; other site 391037001567 active site 391037001568 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 391037001569 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391037001570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 391037001571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037001572 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 391037001573 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 391037001574 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037001575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037001576 motif II; other site 391037001577 glutamate racemase; Provisional; Region: PRK00865 391037001578 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 391037001579 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 391037001580 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 391037001581 active site 391037001582 non-prolyl cis peptide bond; other site 391037001583 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037001584 Predicted ATPase [General function prediction only]; Region: COG5293 391037001585 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 391037001586 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037001587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037001588 non-specific DNA binding site [nucleotide binding]; other site 391037001589 salt bridge; other site 391037001590 sequence-specific DNA binding site [nucleotide binding]; other site 391037001591 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 391037001592 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037001593 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037001594 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 391037001595 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 391037001596 active site 391037001597 zinc binding site [ion binding]; other site 391037001598 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 391037001599 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 391037001600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001601 S-adenosylmethionine binding site [chemical binding]; other site 391037001602 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391037001603 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391037001604 catalytic residues [active] 391037001605 catalytic nucleophile [active] 391037001606 Recombinase; Region: Recombinase; pfam07508 391037001607 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391037001608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037001609 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037001610 active site 391037001611 catalytic tetrad [active] 391037001612 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037001613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037001614 Walker A/P-loop; other site 391037001615 ATP binding site [chemical binding]; other site 391037001616 Q-loop/lid; other site 391037001617 ABC transporter signature motif; other site 391037001618 Walker B; other site 391037001619 D-loop; other site 391037001620 H-loop/switch region; other site 391037001621 Homeodomain-like domain; Region: HTH_23; cl17451 391037001622 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391037001623 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 391037001624 NodB motif; other site 391037001625 putative active site [active] 391037001626 putative catalytic site [active] 391037001627 putative Zn binding site [ion binding]; other site 391037001628 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 391037001629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391037001630 S-ribosylhomocysteinase; Provisional; Region: PRK02260 391037001631 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037001632 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391037001633 AsnC family; Region: AsnC_trans_reg; pfam01037 391037001634 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391037001635 Strictosidine synthase; Region: Str_synth; pfam03088 391037001636 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391037001637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001638 NAD(P) binding site [chemical binding]; other site 391037001639 active site 391037001640 glucose-1-dehydrogenase; Provisional; Region: PRK08936 391037001641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001642 NAD(P) binding site [chemical binding]; other site 391037001643 active site 391037001644 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 391037001645 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037001646 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037001647 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 391037001648 putative NAD(P) binding site [chemical binding]; other site 391037001649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037001650 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 391037001651 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391037001652 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391037001653 Clp protease; Region: CLP_protease; pfam00574 391037001654 oligomer interface [polypeptide binding]; other site 391037001655 active site residues [active] 391037001656 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037001657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037001658 sequence-specific DNA binding site [nucleotide binding]; other site 391037001659 salt bridge; other site 391037001660 Ion channel; Region: Ion_trans_2; pfam07885 391037001661 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 391037001662 TrkA-N domain; Region: TrkA_N; pfam02254 391037001663 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 391037001664 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 391037001665 TPP-binding site [chemical binding]; other site 391037001666 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 391037001667 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391037001668 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391037001669 dimer interface [polypeptide binding]; other site 391037001670 PYR/PP interface [polypeptide binding]; other site 391037001671 TPP binding site [chemical binding]; other site 391037001672 substrate binding site [chemical binding]; other site 391037001673 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 391037001674 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 391037001675 dihydropteroate synthase; Region: DHPS; TIGR01496 391037001676 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391037001677 substrate binding pocket [chemical binding]; other site 391037001678 dimer interface [polypeptide binding]; other site 391037001679 inhibitor binding site; inhibition site 391037001680 DivIVA domain; Region: DivI1A_domain; TIGR03544 391037001681 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391037001682 hydrophobic ligand binding site; other site 391037001683 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 391037001684 enoyl-CoA hydratase; Provisional; Region: PRK08140 391037001685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037001686 substrate binding site [chemical binding]; other site 391037001687 oxyanion hole (OAH) forming residues; other site 391037001688 trimer interface [polypeptide binding]; other site 391037001689 PaaX-like protein; Region: PaaX; pfam07848 391037001690 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 391037001691 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 391037001692 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 391037001693 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391037001694 interface (dimer of trimers) [polypeptide binding]; other site 391037001695 Substrate-binding/catalytic site; other site 391037001696 Zn-binding sites [ion binding]; other site 391037001697 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 391037001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001699 S-adenosylmethionine binding site [chemical binding]; other site 391037001700 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391037001701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391037001702 sec-independent translocase; Provisional; Region: PRK01371 391037001703 sec-independent translocase; Provisional; Region: tatB; PRK00182 391037001704 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 391037001705 Domain of unknown function DUF59; Region: DUF59; pfam01883 391037001706 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391037001707 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 391037001708 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 391037001709 MgtE intracellular N domain; Region: MgtE_N; smart00924 391037001710 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 391037001711 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 391037001712 EamA-like transporter family; Region: EamA; pfam00892 391037001713 short chain dehydrogenase; Provisional; Region: PRK06197 391037001714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001715 NAD(P) binding site [chemical binding]; other site 391037001716 active site 391037001717 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391037001718 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 391037001719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391037001720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037001721 NAD(P) binding site [chemical binding]; other site 391037001722 active site 391037001723 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 391037001724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037001725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037001726 active site 391037001727 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391037001728 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037001729 catalytic residues [active] 391037001730 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391037001731 putative active site [active] 391037001732 putative catalytic site [active] 391037001733 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391037001734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391037001735 Bacterial PH domain; Region: DUF304; pfam03703 391037001736 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 391037001737 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 391037001738 active site 391037001739 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 391037001740 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 391037001741 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391037001742 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391037001743 metal binding site 2 [ion binding]; metal-binding site 391037001744 putative DNA binding helix; other site 391037001745 metal binding site 1 [ion binding]; metal-binding site 391037001746 dimer interface [polypeptide binding]; other site 391037001747 structural Zn2+ binding site [ion binding]; other site 391037001748 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 391037001749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037001750 dimerization interface [polypeptide binding]; other site 391037001751 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037001752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037001753 metal binding site [ion binding]; metal-binding site 391037001754 active site 391037001755 I-site; other site 391037001756 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391037001757 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391037001758 active site 391037001759 tetramer interface; other site 391037001760 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391037001761 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391037001762 dimer interface [polypeptide binding]; other site 391037001763 putative functional site; other site 391037001764 putative MPT binding site; other site 391037001765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037001766 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037001767 HD domain; Region: HD_3; pfam13023 391037001768 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037001769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037001770 non-specific DNA binding site [nucleotide binding]; other site 391037001771 salt bridge; other site 391037001772 sequence-specific DNA binding site [nucleotide binding]; other site 391037001773 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037001774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037001775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037001776 ATP binding site [chemical binding]; other site 391037001777 Mg2+ binding site [ion binding]; other site 391037001778 G-X-G motif; other site 391037001779 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 391037001780 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391037001781 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391037001782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037001783 S-adenosylmethionine binding site [chemical binding]; other site 391037001784 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391037001785 TM-ABC transporter signature motif; other site 391037001786 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391037001787 TM-ABC transporter signature motif; other site 391037001788 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391037001789 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391037001790 Walker A/P-loop; other site 391037001791 ATP binding site [chemical binding]; other site 391037001792 Q-loop/lid; other site 391037001793 ABC transporter signature motif; other site 391037001794 Walker B; other site 391037001795 D-loop; other site 391037001796 H-loop/switch region; other site 391037001797 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391037001798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037001799 Walker A/P-loop; other site 391037001800 ATP binding site [chemical binding]; other site 391037001801 Q-loop/lid; other site 391037001802 ABC transporter signature motif; other site 391037001803 Walker B; other site 391037001804 D-loop; other site 391037001805 H-loop/switch region; other site 391037001806 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 391037001807 Lipase (class 2); Region: Lipase_2; pfam01674 391037001808 PhoD-like phosphatase; Region: PhoD; pfam09423 391037001809 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 391037001810 putative active site [active] 391037001811 putative metal binding site [ion binding]; other site 391037001812 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 391037001813 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 391037001814 NADH dehydrogenase; Region: NADHdh; cl00469 391037001815 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001817 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037001818 enoyl-CoA hydratase; Provisional; Region: PRK05862 391037001819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037001820 substrate binding site [chemical binding]; other site 391037001821 oxyanion hole (OAH) forming residues; other site 391037001822 trimer interface [polypeptide binding]; other site 391037001823 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 391037001824 FAD binding pocket [chemical binding]; other site 391037001825 conserved FAD binding motif [chemical binding]; other site 391037001826 phosphate binding motif [ion binding]; other site 391037001827 beta-alpha-beta structure motif; other site 391037001828 NAD binding pocket [chemical binding]; other site 391037001829 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 391037001830 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037001831 acyl-activating enzyme (AAE) consensus motif; other site 391037001832 AMP binding site [chemical binding]; other site 391037001833 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 391037001834 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037001835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 391037001836 Predicted methyltransferases [General function prediction only]; Region: COG0313 391037001837 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 391037001838 putative SAM binding site [chemical binding]; other site 391037001839 putative homodimer interface [polypeptide binding]; other site 391037001840 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 391037001841 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391037001842 active site 391037001843 HIGH motif; other site 391037001844 KMSKS motif; other site 391037001845 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391037001846 tRNA binding surface [nucleotide binding]; other site 391037001847 anticodon binding site; other site 391037001848 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 391037001849 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 391037001850 Na binding site [ion binding]; other site 391037001851 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391037001852 active site 391037001853 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 391037001854 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 391037001855 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 391037001856 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391037001857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037001858 Walker A/P-loop; other site 391037001859 ATP binding site [chemical binding]; other site 391037001860 ABC transporter signature motif; other site 391037001861 Walker B; other site 391037001862 D-loop; other site 391037001863 H-loop/switch region; other site 391037001864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037001865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037001866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037001867 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 391037001868 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391037001869 Substrate binding site; other site 391037001870 Mg++ binding site; other site 391037001871 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391037001872 active site 391037001873 substrate binding site [chemical binding]; other site 391037001874 CoA binding site [chemical binding]; other site 391037001875 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391037001876 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 391037001877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037001878 active site 391037001879 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 391037001880 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 391037001881 5S rRNA interface [nucleotide binding]; other site 391037001882 CTC domain interface [polypeptide binding]; other site 391037001883 L16 interface [polypeptide binding]; other site 391037001884 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391037001885 putative active site [active] 391037001886 catalytic residue [active] 391037001887 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391037001888 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391037001889 active site 391037001890 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 391037001891 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391037001892 Active Sites [active] 391037001893 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 391037001894 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 391037001895 CysD dimerization site [polypeptide binding]; other site 391037001896 G1 box; other site 391037001897 putative GEF interaction site [polypeptide binding]; other site 391037001898 GTP/Mg2+ binding site [chemical binding]; other site 391037001899 Switch I region; other site 391037001900 G2 box; other site 391037001901 G3 box; other site 391037001902 Switch II region; other site 391037001903 G4 box; other site 391037001904 G5 box; other site 391037001905 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 391037001906 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 391037001907 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 391037001908 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391037001909 NAD binding site [chemical binding]; other site 391037001910 homodimer interface [polypeptide binding]; other site 391037001911 active site 391037001912 substrate binding site [chemical binding]; other site 391037001913 FOG: CBS domain [General function prediction only]; Region: COG0517 391037001914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391037001915 Transporter associated domain; Region: CorC_HlyC; smart01091 391037001916 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391037001917 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391037001918 active site 391037001919 HIGH motif; other site 391037001920 dimer interface [polypeptide binding]; other site 391037001921 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037001922 KMSKS motif; other site 391037001923 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 391037001924 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 391037001925 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 391037001926 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 391037001927 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 391037001928 active site 391037001929 catalytic site [active] 391037001930 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 391037001931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037001932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037001933 DNA binding site [nucleotide binding] 391037001934 domain linker motif; other site 391037001935 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 391037001936 putative dimerization interface [polypeptide binding]; other site 391037001937 putative ligand binding site [chemical binding]; other site 391037001938 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037001939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037001940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037001941 dimer interface [polypeptide binding]; other site 391037001942 conserved gate region; other site 391037001943 putative PBP binding loops; other site 391037001944 ABC-ATPase subunit interface; other site 391037001945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037001946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037001947 dimer interface [polypeptide binding]; other site 391037001948 conserved gate region; other site 391037001949 putative PBP binding loops; other site 391037001950 ABC-ATPase subunit interface; other site 391037001951 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391037001952 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 391037001953 ligand binding site [chemical binding]; other site 391037001954 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391037001955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037001956 Walker A/P-loop; other site 391037001957 ATP binding site [chemical binding]; other site 391037001958 Q-loop/lid; other site 391037001959 ABC transporter signature motif; other site 391037001960 Walker B; other site 391037001961 D-loop; other site 391037001962 H-loop/switch region; other site 391037001963 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391037001964 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037001965 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391037001966 TM-ABC transporter signature motif; other site 391037001967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037001968 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391037001969 TM-ABC transporter signature motif; other site 391037001970 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 391037001971 active site 391037001972 catalytic motif [active] 391037001973 Zn binding site [ion binding]; other site 391037001974 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 391037001975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391037001976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391037001977 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 391037001978 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 391037001979 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 391037001980 adenosine deaminase; Provisional; Region: PRK09358 391037001981 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 391037001982 active site 391037001983 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037001984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037001985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037001986 ATP binding site [chemical binding]; other site 391037001987 Mg2+ binding site [ion binding]; other site 391037001988 G-X-G motif; other site 391037001989 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 391037001990 Protein of unknown function (DUF742); Region: DUF742; pfam05331 391037001991 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 391037001992 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 391037001993 G1 box; other site 391037001994 GTP/Mg2+ binding site [chemical binding]; other site 391037001995 G2 box; other site 391037001996 Switch I region; other site 391037001997 G3 box; other site 391037001998 Switch II region; other site 391037001999 G4 box; other site 391037002000 G5 box; other site 391037002001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037002002 Walker A/P-loop; other site 391037002003 ATP binding site [chemical binding]; other site 391037002004 Q-loop/lid; other site 391037002005 ABC transporter signature motif; other site 391037002006 Walker B; other site 391037002007 D-loop; other site 391037002008 H-loop/switch region; other site 391037002009 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 391037002010 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037002011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037002012 Walker A/P-loop; other site 391037002013 ATP binding site [chemical binding]; other site 391037002014 Q-loop/lid; other site 391037002015 ABC transporter signature motif; other site 391037002016 Walker B; other site 391037002017 D-loop; other site 391037002018 H-loop/switch region; other site 391037002019 Penicillinase repressor; Region: Pencillinase_R; cl17580 391037002020 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037002021 NAD(P) binding site [chemical binding]; other site 391037002022 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391037002023 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037002024 NAD(P) binding site [chemical binding]; other site 391037002025 catalytic residues [active] 391037002026 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391037002027 intersubunit interface [polypeptide binding]; other site 391037002028 active site 391037002029 catalytic residue [active] 391037002030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037002031 active site 391037002032 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 391037002033 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 391037002034 active site 391037002035 substrate binding site [chemical binding]; other site 391037002036 metal binding site [ion binding]; metal-binding site 391037002037 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037002038 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037002039 active site 391037002040 ATP binding site [chemical binding]; other site 391037002041 substrate binding site [chemical binding]; other site 391037002042 activation loop (A-loop); other site 391037002043 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391037002044 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 391037002045 amidohydrolase; Region: amidohydrolases; TIGR01891 391037002046 metal binding site [ion binding]; metal-binding site 391037002047 putative dimer interface [polypeptide binding]; other site 391037002048 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 391037002049 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391037002050 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 391037002051 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391037002052 putative active site pocket [active] 391037002053 dimerization interface [polypeptide binding]; other site 391037002054 putative catalytic residue [active] 391037002055 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 391037002056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037002057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037002058 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391037002059 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037002060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037002061 non-specific DNA binding site [nucleotide binding]; other site 391037002062 salt bridge; other site 391037002063 sequence-specific DNA binding site [nucleotide binding]; other site 391037002064 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391037002065 active site 391037002066 dimer interface [polypeptide binding]; other site 391037002067 motif 1; other site 391037002068 motif 2; other site 391037002069 motif 3; other site 391037002070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037002071 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 391037002072 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037002073 Walker A/P-loop; other site 391037002074 ATP binding site [chemical binding]; other site 391037002075 Q-loop/lid; other site 391037002076 ABC transporter signature motif; other site 391037002077 Walker B; other site 391037002078 D-loop; other site 391037002079 H-loop/switch region; other site 391037002080 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391037002081 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037002082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037002083 Walker A/P-loop; other site 391037002084 ATP binding site [chemical binding]; other site 391037002085 Q-loop/lid; other site 391037002086 ABC transporter signature motif; other site 391037002087 Walker B; other site 391037002088 D-loop; other site 391037002089 H-loop/switch region; other site 391037002090 WHG domain; Region: WHG; pfam13305 391037002091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037002092 MarR family; Region: MarR; pfam01047 391037002093 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037002095 putative substrate translocation pore; other site 391037002096 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 391037002097 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 391037002098 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 391037002099 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391037002100 active site 391037002101 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391037002102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037002103 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391037002104 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391037002105 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391037002106 carboxyltransferase (CT) interaction site; other site 391037002107 biotinylation site [posttranslational modification]; other site 391037002108 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 391037002109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037002110 S-adenosylmethionine binding site [chemical binding]; other site 391037002111 Maf-like protein; Reviewed; Region: PRK00078 391037002112 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391037002113 active site 391037002114 dimer interface [polypeptide binding]; other site 391037002115 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037002116 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 391037002117 active site 391037002118 catalytic residues [active] 391037002119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037002120 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391037002121 active site 391037002122 ATP binding site [chemical binding]; other site 391037002123 substrate binding site [chemical binding]; other site 391037002124 activation loop (A-loop); other site 391037002125 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 391037002126 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 391037002127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037002128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037002129 DNA binding residues [nucleotide binding] 391037002130 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391037002131 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391037002132 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391037002133 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391037002134 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 391037002135 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391037002136 Bacterial PH domain; Region: DUF304; pfam03703 391037002137 Predicted membrane protein [Function unknown]; Region: COG2246 391037002138 GtrA-like protein; Region: GtrA; pfam04138 391037002139 Predicted membrane protein [Function unknown]; Region: COG2246 391037002140 GtrA-like protein; Region: GtrA; pfam04138 391037002141 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 391037002142 active site 391037002143 substrate-binding site [chemical binding]; other site 391037002144 metal-binding site [ion binding] 391037002145 GTP binding site [chemical binding]; other site 391037002146 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037002147 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 391037002148 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 391037002149 catalytic residue [active] 391037002150 putative FPP diphosphate binding site; other site 391037002151 putative FPP binding hydrophobic cleft; other site 391037002152 dimer interface [polypeptide binding]; other site 391037002153 putative IPP diphosphate binding site; other site 391037002154 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 391037002155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037002156 active site 391037002157 motif I; other site 391037002158 motif II; other site 391037002159 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037002160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037002161 non-specific DNA binding site [nucleotide binding]; other site 391037002162 salt bridge; other site 391037002163 sequence-specific DNA binding site [nucleotide binding]; other site 391037002164 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391037002165 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391037002166 catalytic residue [active] 391037002167 Rhomboid family; Region: Rhomboid; pfam01694 391037002168 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391037002169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037002170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037002171 Protein of unknown function, DUF606; Region: DUF606; pfam04657 391037002172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 391037002173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 391037002174 putative active site [active] 391037002175 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 391037002176 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 391037002177 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391037002178 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 391037002179 generic binding surface II; other site 391037002180 generic binding surface I; other site 391037002181 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 391037002182 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 391037002183 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037002184 active site 391037002185 catalytic residues [active] 391037002186 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 391037002187 RmuC family; Region: RmuC; pfam02646 391037002188 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 391037002189 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 391037002190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391037002191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 391037002192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037002193 ATP binding site [chemical binding]; other site 391037002194 putative Mg++ binding site [ion binding]; other site 391037002195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037002196 nucleotide binding region [chemical binding]; other site 391037002197 ATP-binding site [chemical binding]; other site 391037002198 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 391037002199 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 391037002200 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 391037002201 homodimer interface [polypeptide binding]; other site 391037002202 metal binding site [ion binding]; metal-binding site 391037002203 enolase; Provisional; Region: eno; PRK00077 391037002204 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391037002205 dimer interface [polypeptide binding]; other site 391037002206 metal binding site [ion binding]; metal-binding site 391037002207 substrate binding pocket [chemical binding]; other site 391037002208 Septum formation initiator; Region: DivIC; cl17659 391037002209 Protein of unknown function (DUF501); Region: DUF501; pfam04417 391037002210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037002211 Coenzyme A binding pocket [chemical binding]; other site 391037002212 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391037002213 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391037002214 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 391037002215 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 391037002216 dimer interface [polypeptide binding]; other site 391037002217 PYR/PP interface [polypeptide binding]; other site 391037002218 TPP binding site [chemical binding]; other site 391037002219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037002220 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 391037002221 TPP-binding site [chemical binding]; other site 391037002222 dimer interface [polypeptide binding]; other site 391037002223 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391037002224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037002225 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 391037002226 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 391037002227 Fe-S cluster binding site [ion binding]; other site 391037002228 DNA binding site [nucleotide binding] 391037002229 active site 391037002230 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 391037002231 MoxR-like ATPases [General function prediction only]; Region: COG0714 391037002232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037002233 Walker A motif; other site 391037002234 ATP binding site [chemical binding]; other site 391037002235 Walker B motif; other site 391037002236 arginine finger; other site 391037002237 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391037002238 Protein of unknown function DUF58; Region: DUF58; pfam01882 391037002239 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 391037002240 Protein of unknown function (DUF1188); Region: DUF1188; cl01642 391037002241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037002242 Bax inhibitor 1 like; Region: BaxI_1; cl17691 391037002243 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 391037002244 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037002245 dimer interface [polypeptide binding]; other site 391037002246 active site 391037002247 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 391037002248 active site 391037002249 catalytic triad [active] 391037002250 oxyanion hole [active] 391037002251 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 391037002252 active site 391037002253 catalytic triad [active] 391037002254 oxyanion hole [active] 391037002255 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 391037002256 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391037002257 dimer interface [polypeptide binding]; other site 391037002258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037002259 catalytic residue [active] 391037002260 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 391037002261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037002262 Coenzyme A binding pocket [chemical binding]; other site 391037002263 ribonuclease Z; Reviewed; Region: PRK00055 391037002264 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 391037002265 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 391037002266 putative oligomer interface [polypeptide binding]; other site 391037002267 putative active site [active] 391037002268 metal binding site [ion binding]; metal-binding site 391037002269 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 391037002270 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037002271 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037002272 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 391037002273 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 391037002274 active site 391037002275 dimer interface [polypeptide binding]; other site 391037002276 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 391037002277 Ligand Binding Site [chemical binding]; other site 391037002278 Molecular Tunnel; other site 391037002279 methionine sulfoxide reductase A; Provisional; Region: PRK00058 391037002280 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 391037002281 nucleotide binding site/active site [active] 391037002282 HIT family signature motif; other site 391037002283 catalytic residue [active] 391037002284 cystathionine gamma-synthase; Provisional; Region: PRK07811 391037002285 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391037002286 homodimer interface [polypeptide binding]; other site 391037002287 substrate-cofactor binding pocket; other site 391037002288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037002289 catalytic residue [active] 391037002290 amidase; Provisional; Region: PRK06061 391037002291 Amidase; Region: Amidase; cl11426 391037002292 Amidase; Region: Amidase; cl11426 391037002293 threonine dehydratase; Provisional; Region: PRK08198 391037002294 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391037002295 tetramer interface [polypeptide binding]; other site 391037002296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037002297 catalytic residue [active] 391037002298 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 391037002299 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391037002300 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 391037002301 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 391037002302 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 391037002303 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 391037002304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037002305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037002306 metal binding site [ion binding]; metal-binding site 391037002307 active site 391037002308 I-site; other site 391037002309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037002310 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 391037002311 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 391037002312 catalytic residues [active] 391037002313 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 391037002314 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391037002315 ATP-grasp domain; Region: ATP-grasp; pfam02222 391037002316 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 391037002317 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 391037002318 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037002319 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391037002320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037002321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037002322 active site 391037002323 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 391037002324 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 391037002325 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 391037002326 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 391037002327 acyl-activating enzyme (AAE) consensus motif; other site 391037002328 putative AMP binding site [chemical binding]; other site 391037002329 putative active site [active] 391037002330 putative CoA binding site [chemical binding]; other site 391037002331 TIGR03089 family protein; Region: TIGR03089 391037002332 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 391037002333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037002334 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 391037002335 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 391037002336 Substrate binding site; other site 391037002337 Cupin domain; Region: Cupin_2; cl17218 391037002338 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 391037002339 nudix motif; other site 391037002340 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 391037002341 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 391037002342 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 391037002343 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 391037002344 phosphate binding site [ion binding]; other site 391037002345 dimer interface [polypeptide binding]; other site 391037002346 FO synthase; Reviewed; Region: fbiC; PRK09234 391037002347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037002348 FeS/SAM binding site; other site 391037002349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037002350 FeS/SAM binding site; other site 391037002351 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 391037002352 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 391037002353 hypothetical protein; Provisional; Region: PRK06541 391037002354 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037002355 inhibitor-cofactor binding pocket; inhibition site 391037002356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037002357 catalytic residue [active] 391037002358 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391037002359 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391037002360 AsnC family; Region: AsnC_trans_reg; pfam01037 391037002361 Protein of unknown function (DUF779); Region: DUF779; pfam05610 391037002362 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037002363 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037002364 NAD(P) binding site [chemical binding]; other site 391037002365 catalytic residues [active] 391037002366 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391037002367 DNA binding site [nucleotide binding] 391037002368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037002369 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037002370 NAD(P) binding site [chemical binding]; other site 391037002371 catalytic residues [active] 391037002372 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 391037002373 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 391037002374 active site 391037002375 substrate binding site [chemical binding]; other site 391037002376 metal binding site [ion binding]; metal-binding site 391037002377 Uncharacterized conserved protein [Function unknown]; Region: COG2835 391037002378 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 391037002379 dimer interface [polypeptide binding]; other site 391037002380 active site 391037002381 Cation efflux family; Region: Cation_efflux; pfam01545 391037002382 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 391037002383 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 391037002384 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 391037002385 Adenosylhomocysteinase; Provisional; Region: PTZ00075 391037002386 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391037002387 homotetramer interface [polypeptide binding]; other site 391037002388 ligand binding site [chemical binding]; other site 391037002389 catalytic site [active] 391037002390 NAD binding site [chemical binding]; other site 391037002391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037002393 active site 391037002394 phosphorylation site [posttranslational modification] 391037002395 intermolecular recognition site; other site 391037002396 dimerization interface [polypeptide binding]; other site 391037002397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037002398 DNA binding site [nucleotide binding] 391037002399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037002400 dimerization interface [polypeptide binding]; other site 391037002401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037002402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037002403 dimer interface [polypeptide binding]; other site 391037002404 phosphorylation site [posttranslational modification] 391037002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037002406 ATP binding site [chemical binding]; other site 391037002407 Mg2+ binding site [ion binding]; other site 391037002408 G-X-G motif; other site 391037002409 Sporulation and spore germination; Region: Germane; pfam10646 391037002410 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 391037002411 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 391037002412 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 391037002413 30S subunit binding site; other site 391037002414 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037002415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037002416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037002417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037002418 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 391037002419 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391037002420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391037002421 nucleotide binding region [chemical binding]; other site 391037002422 SEC-C motif; Region: SEC-C; pfam02810 391037002423 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037002424 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037002425 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 391037002426 NAD(P) binding site [chemical binding]; other site 391037002427 catalytic residues [active] 391037002428 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037002429 Transcriptional regulator PadR-like family; Region: PadR; cl17335 391037002430 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391037002431 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391037002432 RF-1 domain; Region: RF-1; pfam00472 391037002433 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 391037002434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037002435 Walker A/P-loop; other site 391037002436 ATP binding site [chemical binding]; other site 391037002437 Q-loop/lid; other site 391037002438 ABC transporter signature motif; other site 391037002439 Walker B; other site 391037002440 D-loop; other site 391037002441 H-loop/switch region; other site 391037002442 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 391037002443 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 391037002444 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391037002445 SmpB-tmRNA interface; other site 391037002446 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 391037002447 hypothetical protein; Validated; Region: PRK00228 391037002448 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037002449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037002450 non-specific DNA binding site [nucleotide binding]; other site 391037002451 salt bridge; other site 391037002452 sequence-specific DNA binding site [nucleotide binding]; other site 391037002453 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037002454 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 391037002455 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 391037002456 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 391037002457 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 391037002458 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037002459 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 391037002460 active site 391037002461 catalytic residues [active] 391037002462 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 391037002463 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037002464 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 391037002465 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037002466 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037002467 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 391037002468 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 391037002469 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 391037002470 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037002471 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391037002472 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037002473 DNA-binding site [nucleotide binding]; DNA binding site 391037002474 RNA-binding motif; other site 391037002475 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 391037002476 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 391037002477 SnoaL-like domain; Region: SnoaL_3; pfam13474 391037002478 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 391037002479 SnoaL-like domain; Region: SnoaL_3; pfam13474 391037002480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037002481 RNA polymerase factor sigma-70; Validated; Region: PRK08241 391037002482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037002483 DNA binding residues [nucleotide binding] 391037002484 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391037002485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 391037002486 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 391037002487 CopC domain; Region: CopC; cl01012 391037002488 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 391037002489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037002490 Coenzyme A binding pocket [chemical binding]; other site 391037002491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037002492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037002493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037002494 active site 391037002495 catalytic tetrad [active] 391037002496 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 391037002497 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 391037002498 putative sugar binding sites [chemical binding]; other site 391037002499 Q-X-W motif; other site 391037002500 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 391037002501 putative sugar binding sites [chemical binding]; other site 391037002502 Q-X-W motif; other site 391037002503 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391037002504 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037002505 FAD binding domain; Region: FAD_binding_4; pfam01565 391037002506 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 391037002507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037002508 S-adenosylmethionine binding site [chemical binding]; other site 391037002509 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037002510 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 391037002511 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037002512 DNA binding residues [nucleotide binding] 391037002513 dimer interface [polypeptide binding]; other site 391037002514 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 391037002515 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391037002516 GYD domain; Region: GYD; pfam08734 391037002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037002518 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037002519 putative substrate translocation pore; other site 391037002520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037002521 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 391037002522 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391037002523 NAD binding site [chemical binding]; other site 391037002524 substrate binding site [chemical binding]; other site 391037002525 putative active site [active] 391037002526 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037002527 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037002528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391037002529 Domain of unknown function (DUF385); Region: DUF385; pfam04075 391037002530 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 391037002531 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 391037002532 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037002533 hypothetical protein; Provisional; Region: PRK07236 391037002534 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 391037002535 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 391037002536 D-pathway; other site 391037002537 Putative ubiquinol binding site [chemical binding]; other site 391037002538 Low-spin heme (heme b) binding site [chemical binding]; other site 391037002539 Putative water exit pathway; other site 391037002540 Binuclear center (heme o3/CuB) [ion binding]; other site 391037002541 K-pathway; other site 391037002542 Putative proton exit pathway; other site 391037002543 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391037002544 Isochorismatase family; Region: Isochorismatase; pfam00857 391037002545 catalytic triad [active] 391037002546 metal binding site [ion binding]; metal-binding site 391037002547 conserved cis-peptide bond; other site 391037002548 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 391037002549 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 391037002550 active site 391037002551 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 391037002552 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 391037002553 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 391037002554 MPN+ (JAMM) motif; other site 391037002555 Zinc-binding site [ion binding]; other site 391037002556 Ubiquitin-like proteins; Region: UBQ; cl00155 391037002557 charged pocket; other site 391037002558 hydrophobic patch; other site 391037002559 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391037002560 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391037002561 dimer interface [polypeptide binding]; other site 391037002562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037002563 catalytic residue [active] 391037002564 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 391037002565 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391037002566 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 391037002567 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 391037002568 ribonuclease PH; Reviewed; Region: rph; PRK00173 391037002569 Ribonuclease PH; Region: RNase_PH_bact; cd11362 391037002570 hexamer interface [polypeptide binding]; other site 391037002571 active site 391037002572 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 391037002573 active site 391037002574 dimerization interface [polypeptide binding]; other site 391037002575 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391037002576 active sites [active] 391037002577 tetramer interface [polypeptide binding]; other site 391037002578 imidazolonepropionase; Provisional; Region: PRK14085 391037002579 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 391037002580 active site 391037002581 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391037002582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037002583 active site 391037002584 allantoate amidohydrolase; Reviewed; Region: PRK09290 391037002585 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391037002586 active site 391037002587 metal binding site [ion binding]; metal-binding site 391037002588 dimer interface [polypeptide binding]; other site 391037002589 urocanate hydratase; Provisional; Region: PRK05414 391037002590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391037002591 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391037002592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391037002593 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391037002594 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391037002595 MOSC domain; Region: MOSC; pfam03473 391037002596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037002597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037002598 Coenzyme A binding pocket [chemical binding]; other site 391037002599 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 391037002600 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391037002601 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 391037002602 catalytic triad [active] 391037002603 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 391037002604 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 391037002605 PDGLE domain; Region: PDGLE; pfam13190 391037002606 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 391037002607 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037002608 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391037002609 Walker A/P-loop; other site 391037002610 ATP binding site [chemical binding]; other site 391037002611 Q-loop/lid; other site 391037002612 ABC transporter signature motif; other site 391037002613 Walker B; other site 391037002614 D-loop; other site 391037002615 H-loop/switch region; other site 391037002616 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391037002617 Thioredoxin; Region: Thioredoxin_4; pfam13462 391037002618 CopC domain; Region: CopC; pfam04234 391037002619 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 391037002620 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 391037002621 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 391037002622 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 391037002623 catalytic site [active] 391037002624 putative active site [active] 391037002625 putative substrate binding site [chemical binding]; other site 391037002626 dimer interface [polypeptide binding]; other site 391037002627 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037002628 Bacterial Ig-like domain; Region: Big_5; pfam13205 391037002629 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 391037002630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391037002631 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391037002632 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 391037002633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391037002634 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391037002635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037002636 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037002637 DNA-binding interface [nucleotide binding]; DNA binding site 391037002638 Integrase core domain; Region: rve; pfam00665 391037002639 Integrase core domain; Region: rve_3; cl15866 391037002640 transposase; Provisional; Region: PRK06526 391037002641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037002642 Walker A motif; other site 391037002643 ATP binding site [chemical binding]; other site 391037002644 Walker B motif; other site 391037002645 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037002646 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 391037002647 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037002648 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037002649 hypothetical protein; Provisional; Region: PRK06762 391037002650 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 391037002651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037002652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037002653 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037002654 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 391037002655 putative NAD(P) binding site [chemical binding]; other site 391037002656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037002657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037002658 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 391037002659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037002660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037002661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037002662 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391037002663 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391037002664 acyl-activating enzyme (AAE) consensus motif; other site 391037002665 putative AMP binding site [chemical binding]; other site 391037002666 putative active site [active] 391037002667 putative CoA binding site [chemical binding]; other site 391037002668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037002669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037002670 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391037002671 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391037002672 acyl-activating enzyme (AAE) consensus motif; other site 391037002673 putative AMP binding site [chemical binding]; other site 391037002674 putative active site [active] 391037002675 putative CoA binding site [chemical binding]; other site 391037002676 Cupin domain; Region: Cupin_2; pfam07883 391037002677 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 391037002678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037002679 active site 391037002680 nucleotide binding site [chemical binding]; other site 391037002681 HIGH motif; other site 391037002682 KMSKS motif; other site 391037002683 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391037002684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037002685 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 391037002686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037002687 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 391037002688 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 391037002689 active site 391037002690 ligand binding site [chemical binding]; other site 391037002691 homodimer interface [polypeptide binding]; other site 391037002692 NAD(P) binding site [chemical binding]; other site 391037002693 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037002694 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391037002695 active site 391037002696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037002697 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 391037002698 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391037002699 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 391037002700 FAD binding pocket [chemical binding]; other site 391037002701 FAD binding motif [chemical binding]; other site 391037002702 phosphate binding motif [ion binding]; other site 391037002703 beta-alpha-beta structure motif; other site 391037002704 NAD binding pocket [chemical binding]; other site 391037002705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037002706 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391037002707 catalytic loop [active] 391037002708 iron binding site [ion binding]; other site 391037002709 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391037002710 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391037002711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037002712 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037002713 acyl-activating enzyme (AAE) consensus motif; other site 391037002714 AMP binding site [chemical binding]; other site 391037002715 active site 391037002716 CoA binding site [chemical binding]; other site 391037002717 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 391037002718 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 391037002719 tetramer interface [polypeptide binding]; other site 391037002720 active site 391037002721 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 391037002722 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037002723 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 391037002724 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391037002725 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037002726 active site 391037002727 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037002728 active site 2 [active] 391037002729 active site 1 [active] 391037002730 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391037002731 active site 391037002732 catalytic site [active] 391037002733 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 391037002734 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 391037002735 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037002736 active site 391037002737 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391037002738 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391037002739 NAD(P) binding site [chemical binding]; other site 391037002740 homotetramer interface [polypeptide binding]; other site 391037002741 homodimer interface [polypeptide binding]; other site 391037002742 active site 391037002743 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 391037002744 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391037002745 FAD binding pocket [chemical binding]; other site 391037002746 FAD binding motif [chemical binding]; other site 391037002747 phosphate binding motif [ion binding]; other site 391037002748 beta-alpha-beta structure motif; other site 391037002749 NAD binding pocket [chemical binding]; other site 391037002750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037002751 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391037002752 catalytic loop [active] 391037002753 iron binding site [ion binding]; other site 391037002754 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391037002755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037002756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037002757 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 391037002758 NAD(P) binding site [chemical binding]; other site 391037002759 active site 391037002760 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002761 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002762 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002763 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002764 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002766 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037002767 FAD binding domain; Region: FAD_binding_4; pfam01565 391037002768 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 391037002769 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 391037002770 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037002771 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037002772 short chain dehydrogenase; Provisional; Region: PRK07109 391037002773 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 391037002774 putative NAD(P) binding site [chemical binding]; other site 391037002775 active site 391037002776 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 391037002777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037002778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037002779 DNA binding site [nucleotide binding] 391037002780 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391037002781 dimerization interface [polypeptide binding]; other site 391037002782 ligand binding site [chemical binding]; other site 391037002783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037002784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037002785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391037002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037002787 dimer interface [polypeptide binding]; other site 391037002788 putative PBP binding loops; other site 391037002789 ABC-ATPase subunit interface; other site 391037002790 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037002792 dimer interface [polypeptide binding]; other site 391037002793 conserved gate region; other site 391037002794 putative PBP binding loops; other site 391037002795 ABC-ATPase subunit interface; other site 391037002796 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 391037002797 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 391037002798 putative active site [active] 391037002799 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037002800 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 391037002801 active site 391037002802 catalytic site [active] 391037002803 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 391037002804 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 391037002805 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002806 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037002807 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002808 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037002809 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002810 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002811 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037002812 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037002813 Protein of unknown function DUF72; Region: DUF72; pfam01904 391037002814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037002815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037002816 dimer interface [polypeptide binding]; other site 391037002817 phosphorylation site [posttranslational modification] 391037002818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037002819 ATP binding site [chemical binding]; other site 391037002820 Mg2+ binding site [ion binding]; other site 391037002821 G-X-G motif; other site 391037002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037002823 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 391037002824 active site 391037002825 phosphorylation site [posttranslational modification] 391037002826 intermolecular recognition site; other site 391037002827 dimerization interface [polypeptide binding]; other site 391037002828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037002829 DNA binding site [nucleotide binding] 391037002830 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391037002831 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391037002832 non-specific DNA interactions [nucleotide binding]; other site 391037002833 DNA binding site [nucleotide binding] 391037002834 sequence specific DNA binding site [nucleotide binding]; other site 391037002835 putative cAMP binding site [chemical binding]; other site 391037002836 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037002837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391037002838 nucleotide binding site [chemical binding]; other site 391037002839 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391037002840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037002841 Walker A/P-loop; other site 391037002842 ATP binding site [chemical binding]; other site 391037002843 ABC transporter signature motif; other site 391037002844 Walker B; other site 391037002845 D-loop; other site 391037002846 H-loop/switch region; other site 391037002847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391037002848 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391037002849 substrate binding site [chemical binding]; other site 391037002850 dimer interface [polypeptide binding]; other site 391037002851 ATP binding site [chemical binding]; other site 391037002852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037002853 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037002854 enoyl-CoA hydratase; Provisional; Region: PRK05862 391037002855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037002856 substrate binding site [chemical binding]; other site 391037002857 oxyanion hole (OAH) forming residues; other site 391037002858 trimer interface [polypeptide binding]; other site 391037002859 hypothetical protein; Provisional; Region: PRK05858 391037002860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391037002861 PYR/PP interface [polypeptide binding]; other site 391037002862 dimer interface [polypeptide binding]; other site 391037002863 TPP binding site [chemical binding]; other site 391037002864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037002865 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 391037002866 TPP-binding site; other site 391037002867 dimer interface [polypeptide binding]; other site 391037002868 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 391037002869 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391037002870 Ligand binding site [chemical binding]; other site 391037002871 Electron transfer flavoprotein domain; Region: ETF; pfam01012 391037002872 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391037002873 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391037002874 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391037002875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 391037002876 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 391037002877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391037002878 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 391037002879 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391037002880 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 391037002881 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 391037002882 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 391037002883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037002884 catalytic residue [active] 391037002885 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 391037002886 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 391037002887 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 391037002888 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391037002889 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391037002890 nucleotide binding pocket [chemical binding]; other site 391037002891 K-X-D-G motif; other site 391037002892 catalytic site [active] 391037002893 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391037002894 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391037002895 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 391037002896 Dimer interface [polypeptide binding]; other site 391037002897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037002898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037002899 metal binding site [ion binding]; metal-binding site 391037002900 active site 391037002901 I-site; other site 391037002902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037002903 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 391037002904 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391037002905 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 391037002906 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391037002907 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391037002908 GatB domain; Region: GatB_Yqey; smart00845 391037002909 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391037002910 TPP-binding site [chemical binding]; other site 391037002911 PYR/PP interface [polypeptide binding]; other site 391037002912 dimer interface [polypeptide binding]; other site 391037002913 TPP binding site [chemical binding]; other site 391037002914 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 391037002915 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391037002916 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391037002917 active site 391037002918 metal binding site [ion binding]; metal-binding site 391037002919 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 391037002920 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 391037002921 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 391037002922 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 391037002923 putative ligand binding site [chemical binding]; other site 391037002924 putative NAD binding site [chemical binding]; other site 391037002925 catalytic site [active] 391037002926 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 391037002927 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037002928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037002929 DNA binding site [nucleotide binding] 391037002930 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391037002931 ligand binding site [chemical binding]; other site 391037002932 dimerization interface [polypeptide binding]; other site 391037002933 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 391037002934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037002935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037002936 metal binding site [ion binding]; metal-binding site 391037002937 active site 391037002938 I-site; other site 391037002939 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037002940 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 391037002941 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391037002942 PYR/PP interface [polypeptide binding]; other site 391037002943 dimer interface [polypeptide binding]; other site 391037002944 TPP binding site [chemical binding]; other site 391037002945 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037002946 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391037002947 TPP-binding site [chemical binding]; other site 391037002948 dimer interface [polypeptide binding]; other site 391037002949 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391037002950 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391037002951 putative valine binding site [chemical binding]; other site 391037002952 dimer interface [polypeptide binding]; other site 391037002953 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391037002954 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391037002955 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 391037002956 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391037002957 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391037002958 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 391037002959 ligand binding site [chemical binding]; other site 391037002960 NAD binding site [chemical binding]; other site 391037002961 dimerization interface [polypeptide binding]; other site 391037002962 catalytic site [active] 391037002963 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 391037002964 putative L-serine binding site [chemical binding]; other site 391037002965 ApbE family; Region: ApbE; pfam02424 391037002966 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 391037002967 tartrate dehydrogenase; Region: TTC; TIGR02089 391037002968 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 391037002969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 391037002970 homodimer interface [polypeptide binding]; other site 391037002971 substrate-cofactor binding pocket; other site 391037002972 catalytic residue [active] 391037002973 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 391037002974 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 391037002975 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 391037002976 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 391037002977 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 391037002978 active site 391037002979 catalytic residues [active] 391037002980 metal binding site [ion binding]; metal-binding site 391037002981 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391037002982 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037002983 putative catalytic site [active] 391037002984 putative metal binding site [ion binding]; other site 391037002985 putative phosphate binding site [ion binding]; other site 391037002986 MoxR-like ATPases [General function prediction only]; Region: COG0714 391037002987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037002988 Walker A motif; other site 391037002989 ATP binding site [chemical binding]; other site 391037002990 Walker B motif; other site 391037002991 arginine finger; other site 391037002992 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391037002993 Protein of unknown function DUF58; Region: DUF58; pfam01882 391037002994 hypothetical protein; Provisional; Region: PRK13685 391037002995 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 391037002996 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391037002997 metal ion-dependent adhesion site (MIDAS); other site 391037002998 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391037002999 hypothetical protein; Provisional; Region: PRK09256 391037003000 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 391037003001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037003002 hypothetical protein; Provisional; Region: PRK07588 391037003003 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037003004 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391037003005 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391037003006 active site 391037003007 HIGH motif; other site 391037003008 dimer interface [polypeptide binding]; other site 391037003009 KMSKS motif; other site 391037003010 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 391037003011 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391037003012 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391037003013 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391037003014 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391037003015 Bacterial transcriptional regulator; Region: IclR; pfam01614 391037003016 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391037003017 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391037003018 substrate binding site [chemical binding]; other site 391037003019 ligand binding site [chemical binding]; other site 391037003020 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391037003021 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391037003022 substrate binding site [chemical binding]; other site 391037003023 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391037003024 IHF dimer interface [polypeptide binding]; other site 391037003025 IHF - DNA interface [nucleotide binding]; other site 391037003026 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 391037003027 active site 391037003028 Ap6A binding site [chemical binding]; other site 391037003029 nudix motif; other site 391037003030 metal binding site [ion binding]; metal-binding site 391037003031 polyphosphate kinase; Provisional; Region: PRK05443 391037003032 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 391037003033 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 391037003034 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 391037003035 putative domain interface [polypeptide binding]; other site 391037003036 putative active site [active] 391037003037 catalytic site [active] 391037003038 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 391037003039 putative domain interface [polypeptide binding]; other site 391037003040 putative active site [active] 391037003041 catalytic site [active] 391037003042 Guanylyl transferase CofC like; Region: CofC; cl17472 391037003043 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037003044 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391037003045 putative acyl-acceptor binding pocket; other site 391037003046 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391037003047 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391037003048 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391037003049 cystathionine gamma-lyase; Validated; Region: PRK07582 391037003050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037003051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037003052 catalytic residue [active] 391037003053 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037003054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037003055 non-specific DNA binding site [nucleotide binding]; other site 391037003056 salt bridge; other site 391037003057 sequence-specific DNA binding site [nucleotide binding]; other site 391037003058 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 391037003059 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391037003060 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 391037003061 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037003062 AsnC family; Region: AsnC_trans_reg; pfam01037 391037003063 thiamine monophosphate kinase; Provisional; Region: PRK05731 391037003064 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 391037003065 ATP binding site [chemical binding]; other site 391037003066 dimerization interface [polypeptide binding]; other site 391037003067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037003068 Coenzyme A binding pocket [chemical binding]; other site 391037003069 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391037003070 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 391037003071 DAK2 domain; Region: Dak2; pfam02734 391037003072 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391037003073 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391037003074 generic binding surface II; other site 391037003075 ssDNA binding site; other site 391037003076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037003077 ATP binding site [chemical binding]; other site 391037003078 putative Mg++ binding site [ion binding]; other site 391037003079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037003080 nucleotide binding region [chemical binding]; other site 391037003081 ATP-binding site [chemical binding]; other site 391037003082 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 391037003083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037003084 S-adenosylmethionine binding site [chemical binding]; other site 391037003085 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391037003086 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 391037003087 active site 391037003088 (T/H)XGH motif; other site 391037003089 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 391037003090 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 391037003091 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 391037003092 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 391037003093 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 391037003094 dimerization interface [polypeptide binding]; other site 391037003095 active site 391037003096 metal binding site [ion binding]; metal-binding site 391037003097 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 391037003098 dsRNA binding site [nucleotide binding]; other site 391037003099 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391037003100 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391037003101 DNA binding site [nucleotide binding] 391037003102 catalytic residue [active] 391037003103 H2TH interface [polypeptide binding]; other site 391037003104 putative catalytic residues [active] 391037003105 turnover-facilitating residue; other site 391037003106 intercalation triad [nucleotide binding]; other site 391037003107 8OG recognition residue [nucleotide binding]; other site 391037003108 putative reading head residues; other site 391037003109 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391037003110 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391037003111 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391037003112 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 391037003113 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391037003114 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391037003115 AAA domain; Region: AAA_23; pfam13476 391037003116 Walker A/P-loop; other site 391037003117 ATP binding site [chemical binding]; other site 391037003118 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391037003119 ABC transporter signature motif; other site 391037003120 Walker B; other site 391037003121 D-loop; other site 391037003122 H-loop/switch region; other site 391037003123 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037003124 Protein of unknown function (DUF664); Region: DUF664; pfam04978 391037003125 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 391037003126 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391037003127 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391037003128 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 391037003129 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391037003130 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 391037003131 Phosphotransferase enzyme family; Region: APH; pfam01636 391037003132 active site 391037003133 substrate binding site [chemical binding]; other site 391037003134 ATP binding site [chemical binding]; other site 391037003135 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 391037003136 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391037003137 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391037003138 PII uridylyl-transferase; Provisional; Region: PRK03381 391037003139 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 391037003140 metal binding triad [ion binding]; metal-binding site 391037003141 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391037003142 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391037003143 signal recognition particle protein; Provisional; Region: PRK10867 391037003144 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391037003145 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391037003146 P loop; other site 391037003147 GTP binding site [chemical binding]; other site 391037003148 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391037003149 Amidohydrolase; Region: Amidohydro_4; pfam13147 391037003150 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037003151 active site 391037003152 prolyl-tRNA synthetase; Provisional; Region: PRK08661 391037003153 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 391037003154 dimer interface [polypeptide binding]; other site 391037003155 motif 1; other site 391037003156 active site 391037003157 motif 2; other site 391037003158 motif 3; other site 391037003159 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 391037003160 anticodon binding site; other site 391037003161 Protein of unknown function (DUF402); Region: DUF402; pfam04167 391037003162 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 391037003163 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 391037003164 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 391037003165 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 391037003166 RimM N-terminal domain; Region: RimM; pfam01782 391037003167 PRC-barrel domain; Region: PRC; pfam05239 391037003168 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 391037003169 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 391037003170 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391037003171 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391037003172 Catalytic site [active] 391037003173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391037003174 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391037003175 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391037003176 Catalytic site [active] 391037003177 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391037003178 RNA/DNA hybrid binding site [nucleotide binding]; other site 391037003179 active site 391037003180 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 391037003181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037003182 dimerization interface [polypeptide binding]; other site 391037003183 putative DNA binding site [nucleotide binding]; other site 391037003184 putative Zn2+ binding site [ion binding]; other site 391037003185 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 391037003186 putative hydrophobic ligand binding site [chemical binding]; other site 391037003187 RibD C-terminal domain; Region: RibD_C; cl17279 391037003188 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 391037003189 active site 391037003190 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391037003191 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037003192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037003193 active site 391037003194 DNA binding site [nucleotide binding] 391037003195 Int/Topo IB signature motif; other site 391037003196 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 391037003197 DNA protecting protein DprA; Region: dprA; TIGR00732 391037003198 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 391037003199 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 391037003200 DNA-binding residues [nucleotide binding]; DNA binding site 391037003201 nucleotide binding site [chemical binding]; other site 391037003202 polymerase nucleotide-binding site; other site 391037003203 primase nucleotide-binding site [nucleotide binding]; other site 391037003204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037003205 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 391037003206 metal binding site 2 [ion binding]; metal-binding site 391037003207 putative DNA binding helix; other site 391037003208 metal binding site 1 [ion binding]; metal-binding site 391037003209 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037003210 nudix motif; other site 391037003211 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 391037003212 active site 391037003213 ATP binding site [chemical binding]; other site 391037003214 Phosphotransferase enzyme family; Region: APH; pfam01636 391037003215 substrate binding site [chemical binding]; other site 391037003216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037003217 DNA-binding site [nucleotide binding]; DNA binding site 391037003218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037003219 DNA-binding site [nucleotide binding]; DNA binding site 391037003220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037003221 DNA-binding site [nucleotide binding]; DNA binding site 391037003222 hypothetical protein; Reviewed; Region: PRK12497 391037003223 envelope glycoprotein D; Provisional; Region: PHA03264 391037003224 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391037003225 rRNA interaction site [nucleotide binding]; other site 391037003226 S8 interaction site; other site 391037003227 putative laminin-1 binding site; other site 391037003228 elongation factor Ts; Provisional; Region: tsf; PRK09377 391037003229 UBA/TS-N domain; Region: UBA; pfam00627 391037003230 Elongation factor TS; Region: EF_TS; pfam00889 391037003231 Elongation factor TS; Region: EF_TS; pfam00889 391037003232 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 391037003233 putative nucleotide binding site [chemical binding]; other site 391037003234 uridine monophosphate binding site [chemical binding]; other site 391037003235 homohexameric interface [polypeptide binding]; other site 391037003236 ribosome recycling factor; Reviewed; Region: frr; PRK00083 391037003237 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 391037003238 hinge region; other site 391037003239 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391037003240 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 391037003241 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 391037003242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037003243 FeS/SAM binding site; other site 391037003244 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 391037003245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391037003246 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391037003247 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 391037003248 iron-sulfur cluster [ion binding]; other site 391037003249 [2Fe-2S] cluster binding site [ion binding]; other site 391037003250 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391037003251 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391037003252 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391037003253 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037003254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037003255 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391037003256 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037003257 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037003258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037003259 Cytochrome P450; Region: p450; cl12078 391037003260 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037003261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037003262 acyl-activating enzyme (AAE) consensus motif; other site 391037003263 AMP binding site [chemical binding]; other site 391037003264 active site 391037003265 CoA binding site [chemical binding]; other site 391037003266 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003269 active site 391037003270 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003271 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003272 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003273 putative NADP binding site [chemical binding]; other site 391037003274 KR domain; Region: KR; pfam08659 391037003275 active site 391037003276 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003277 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003279 active site 391037003280 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003282 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003284 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037003285 active site 391037003286 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037003287 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003288 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 391037003289 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003290 NADP binding site [chemical binding]; other site 391037003291 active site 391037003292 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003293 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003294 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003295 active site 391037003296 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003297 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003298 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003299 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003300 putative NADP binding site [chemical binding]; other site 391037003301 active site 391037003302 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003303 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003304 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003305 active site 391037003306 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003307 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003308 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003309 putative NADP binding site [chemical binding]; other site 391037003310 KR domain; Region: KR; pfam08659 391037003311 active site 391037003312 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003313 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003314 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003315 active site 391037003316 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003317 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003318 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003319 putative NADP binding site [chemical binding]; other site 391037003320 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003321 active site 391037003322 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003323 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003324 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003325 active site 391037003326 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003327 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003328 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003329 putative NADP binding site [chemical binding]; other site 391037003330 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003331 active site 391037003332 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003333 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003334 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003335 active site 391037003336 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003337 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003338 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003339 putative NADP binding site [chemical binding]; other site 391037003340 KR domain; Region: KR; pfam08659 391037003341 active site 391037003342 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003343 Erythronolide synthase docking; Region: Docking; pfam08990 391037003344 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003346 active site 391037003347 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003348 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003349 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003350 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003351 putative NADP binding site [chemical binding]; other site 391037003352 active site 391037003353 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003354 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037003355 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037003356 active site 391037003357 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037003358 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037003359 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037003360 putative NADP binding site [chemical binding]; other site 391037003361 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037003362 active site 391037003363 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037003364 N-acetyltransferase; Region: Acetyltransf_2; cl00949 391037003365 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391037003366 dimer interface [polypeptide binding]; other site 391037003367 active site 391037003368 metal binding site [ion binding]; metal-binding site 391037003369 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 391037003370 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391037003371 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391037003372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037003373 inhibitor-cofactor binding pocket; inhibition site 391037003374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037003375 catalytic residue [active] 391037003376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037003377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037003378 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391037003379 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 391037003380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037003381 motif II; other site 391037003382 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 391037003383 [2Fe-2S] cluster binding site [ion binding]; other site 391037003384 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037003385 Cytochrome P450; Region: p450; cl12078 391037003386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037003387 Cytochrome P450; Region: p450; cl12078 391037003388 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 391037003389 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 391037003390 acyltransferase PapA5; Provisional; Region: PRK09294 391037003391 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037003392 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037003393 homodimer interface [polypeptide binding]; other site 391037003394 active site 391037003395 TDP-binding site; other site 391037003396 acceptor substrate-binding pocket; other site 391037003397 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 391037003398 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037003399 inhibitor-cofactor binding pocket; inhibition site 391037003400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037003401 catalytic residue [active] 391037003402 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391037003403 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037003404 inhibitor-cofactor binding pocket; inhibition site 391037003405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037003406 catalytic residue [active] 391037003407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037003408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037003409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391037003410 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037003411 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037003412 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 391037003413 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037003414 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 391037003415 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037003416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037003417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037003418 DNA binding residues [nucleotide binding] 391037003419 dimerization interface [polypeptide binding]; other site 391037003420 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 391037003421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037003422 S-adenosylmethionine binding site [chemical binding]; other site 391037003423 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391037003424 TPP-binding site [chemical binding]; other site 391037003425 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 391037003426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391037003427 PYR/PP interface [polypeptide binding]; other site 391037003428 dimer interface [polypeptide binding]; other site 391037003429 TPP binding site [chemical binding]; other site 391037003430 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391037003431 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391037003432 shikimate binding site; other site 391037003433 NAD(P) binding site [chemical binding]; other site 391037003434 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037003435 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391037003436 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391037003437 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391037003438 active site 391037003439 trimer interface [polypeptide binding]; other site 391037003440 dimer interface [polypeptide binding]; other site 391037003441 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391037003442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037003443 Family description; Region: VCBS; pfam13517 391037003444 Family description; Region: VCBS; pfam13517 391037003445 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 391037003446 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 391037003447 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 391037003448 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 391037003449 putative sugar binding sites [chemical binding]; other site 391037003450 Q-X-W motif; other site 391037003451 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391037003452 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 391037003453 protein-splicing catalytic site; other site 391037003454 thioester formation/cholesterol transfer; other site 391037003455 Pretoxin HINT domain; Region: PT-HINT; pfam07591 391037003456 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 391037003457 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 391037003458 Cytochrome P450; Region: p450; cl12078 391037003459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037003460 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391037003461 substrate binding pocket [chemical binding]; other site 391037003462 substrate-Mg2+ binding site; other site 391037003463 aspartate-rich region 1; other site 391037003464 aspartate-rich region 2; other site 391037003465 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 391037003466 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037003467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037003468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037003469 ATP binding site [chemical binding]; other site 391037003470 Mg2+ binding site [ion binding]; other site 391037003471 G-X-G motif; other site 391037003472 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 391037003473 Protein of unknown function (DUF742); Region: DUF742; pfam05331 391037003474 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 391037003475 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 391037003476 G1 box; other site 391037003477 GTP/Mg2+ binding site [chemical binding]; other site 391037003478 G2 box; other site 391037003479 Switch I region; other site 391037003480 G3 box; other site 391037003481 Switch II region; other site 391037003482 G4 box; other site 391037003483 G5 box; other site 391037003484 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 391037003485 Uncharacterized conserved protein [Function unknown]; Region: COG5361 391037003486 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 391037003487 Clp amino terminal domain; Region: Clp_N; pfam02861 391037003488 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 391037003489 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391037003490 active site 391037003491 catalytic triad [active] 391037003492 dimer interface [polypeptide binding]; other site 391037003493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037003494 non-specific DNA binding site [nucleotide binding]; other site 391037003495 salt bridge; other site 391037003496 sequence-specific DNA binding site [nucleotide binding]; other site 391037003497 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037003498 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391037003499 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391037003500 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391037003501 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 391037003502 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 391037003503 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391037003504 active site 391037003505 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391037003506 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391037003507 putative substrate binding region [chemical binding]; other site 391037003508 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391037003509 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391037003510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391037003511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037003512 short chain dehydrogenase; Provisional; Region: PRK12937 391037003513 NAD(P) binding site [chemical binding]; other site 391037003514 active site 391037003515 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391037003516 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391037003517 NADP binding site [chemical binding]; other site 391037003518 active site 391037003519 steroid binding site; other site 391037003520 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 391037003521 active site 1 [active] 391037003522 dimer interface [polypeptide binding]; other site 391037003523 hexamer interface [polypeptide binding]; other site 391037003524 active site 2 [active] 391037003525 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037003526 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 391037003527 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 391037003528 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037003529 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 391037003530 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037003531 DNA binding residues [nucleotide binding] 391037003532 Protein of unknown function (DUF664); Region: DUF664; pfam04978 391037003533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 391037003534 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 391037003535 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 391037003536 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037003537 dimer interface [polypeptide binding]; other site 391037003538 active site 391037003539 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037003540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037003541 S-adenosylmethionine binding site [chemical binding]; other site 391037003542 PAS domain S-box; Region: sensory_box; TIGR00229 391037003543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391037003544 putative active site [active] 391037003545 heme pocket [chemical binding]; other site 391037003546 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037003547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037003548 metal binding site [ion binding]; metal-binding site 391037003549 active site 391037003550 I-site; other site 391037003551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037003552 methionine aminopeptidase; Provisional; Region: PRK12318 391037003553 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391037003554 active site 391037003555 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 391037003556 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 391037003557 Sm and related proteins; Region: Sm_like; cl00259 391037003558 Sm and related proteins; Region: Sm_like; cl00259 391037003559 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 391037003560 NusA N-terminal domain; Region: NusA_N; pfam08529 391037003561 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 391037003562 RNA binding site [nucleotide binding]; other site 391037003563 homodimer interface [polypeptide binding]; other site 391037003564 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391037003565 G-X-X-G motif; other site 391037003566 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391037003567 G-X-X-G motif; other site 391037003568 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 391037003569 putative RNA binding cleft [nucleotide binding]; other site 391037003570 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391037003571 translation initiation factor IF-2; Region: IF-2; TIGR00487 391037003572 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391037003573 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 391037003574 G1 box; other site 391037003575 putative GEF interaction site [polypeptide binding]; other site 391037003576 GTP/Mg2+ binding site [chemical binding]; other site 391037003577 Switch I region; other site 391037003578 G2 box; other site 391037003579 G3 box; other site 391037003580 Switch II region; other site 391037003581 G4 box; other site 391037003582 G5 box; other site 391037003583 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 391037003584 Translation-initiation factor 2; Region: IF-2; pfam11987 391037003585 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 391037003586 Protein of unknown function (DUF503); Region: DUF503; pfam04456 391037003587 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 391037003588 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 391037003589 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391037003590 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391037003591 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 391037003592 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 391037003593 RNA binding site [nucleotide binding]; other site 391037003594 active site 391037003595 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 391037003596 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391037003597 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391037003598 active site 391037003599 Riboflavin kinase; Region: Flavokinase; pfam01687 391037003600 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 391037003601 16S/18S rRNA binding site [nucleotide binding]; other site 391037003602 S13e-L30e interaction site [polypeptide binding]; other site 391037003603 25S rRNA binding site [nucleotide binding]; other site 391037003604 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 391037003605 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 391037003606 RNase E interface [polypeptide binding]; other site 391037003607 trimer interface [polypeptide binding]; other site 391037003608 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391037003609 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 391037003610 RNase E interface [polypeptide binding]; other site 391037003611 trimer interface [polypeptide binding]; other site 391037003612 active site 391037003613 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391037003614 putative nucleic acid binding region [nucleotide binding]; other site 391037003615 G-X-X-G motif; other site 391037003616 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 391037003617 RNA binding site [nucleotide binding]; other site 391037003618 domain interface; other site 391037003619 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391037003620 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391037003621 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391037003622 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391037003623 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 391037003624 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391037003625 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037003626 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 391037003627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 391037003628 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 391037003629 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 391037003630 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 391037003631 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391037003632 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391037003633 dimer interface [polypeptide binding]; other site 391037003634 active site 391037003635 catalytic residue [active] 391037003636 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 391037003637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391037003638 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 391037003639 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 391037003640 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 391037003641 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 391037003642 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391037003643 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037003644 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 391037003645 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391037003646 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 391037003647 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391037003648 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 391037003649 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391037003650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037003651 FeS/SAM binding site; other site 391037003652 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391037003653 Competence-damaged protein; Region: CinA; pfam02464 391037003654 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037003655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037003656 non-specific DNA binding site [nucleotide binding]; other site 391037003657 salt bridge; other site 391037003658 sequence-specific DNA binding site [nucleotide binding]; other site 391037003659 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 391037003660 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037003661 Interdomain contacts; other site 391037003662 Cytokine receptor motif; other site 391037003663 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037003664 Interdomain contacts; other site 391037003665 Cytokine receptor motif; other site 391037003666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037003667 non-specific DNA binding site [nucleotide binding]; other site 391037003668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037003669 salt bridge; other site 391037003670 sequence-specific DNA binding site [nucleotide binding]; other site 391037003671 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 391037003672 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391037003673 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 391037003674 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 391037003675 putative DNA binding site [nucleotide binding]; other site 391037003676 catalytic residue [active] 391037003677 putative H2TH interface [polypeptide binding]; other site 391037003678 putative catalytic residues [active] 391037003679 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391037003680 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391037003681 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 391037003682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037003683 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 391037003684 ATP binding site [chemical binding]; other site 391037003685 putative Mg++ binding site [ion binding]; other site 391037003686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037003687 nucleotide binding region [chemical binding]; other site 391037003688 ATP-binding site [chemical binding]; other site 391037003689 DEAD/H associated; Region: DEAD_assoc; pfam08494 391037003690 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 391037003691 Peptidase family M28; Region: Peptidase_M28; pfam04389 391037003692 active site 391037003693 metal binding site [ion binding]; metal-binding site 391037003694 Domain of unknown function DUF21; Region: DUF21; pfam01595 391037003695 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 391037003696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391037003697 Transporter associated domain; Region: CorC_HlyC; pfam03471 391037003698 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 391037003699 Domain of unknown function DUF21; Region: DUF21; pfam01595 391037003700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391037003701 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 391037003702 leucine export protein LeuE; Provisional; Region: PRK10958 391037003703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037003704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037003705 putative substrate translocation pore; other site 391037003706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037003707 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037003708 Family description; Region: VCBS; pfam13517 391037003709 Family description; Region: VCBS; pfam13517 391037003710 Family description; Region: VCBS; pfam13517 391037003711 Family description; Region: VCBS; pfam13517 391037003712 Family description; Region: VCBS; pfam13517 391037003713 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391037003714 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037003715 Family description; Region: VCBS; pfam13517 391037003716 Family description; Region: VCBS; pfam13517 391037003717 Family description; Region: VCBS; pfam13517 391037003718 Family description; Region: VCBS; pfam13517 391037003719 Family description; Region: VCBS; pfam13517 391037003720 Predicted transcriptional regulators [Transcription]; Region: COG1378 391037003721 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391037003722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037003723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037003724 dimerization interface [polypeptide binding]; other site 391037003725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037003726 dimer interface [polypeptide binding]; other site 391037003727 phosphorylation site [posttranslational modification] 391037003728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037003729 ATP binding site [chemical binding]; other site 391037003730 Mg2+ binding site [ion binding]; other site 391037003731 G-X-G motif; other site 391037003732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037003733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037003734 active site 391037003735 phosphorylation site [posttranslational modification] 391037003736 intermolecular recognition site; other site 391037003737 dimerization interface [polypeptide binding]; other site 391037003738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037003739 DNA binding site [nucleotide binding] 391037003740 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 391037003741 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 391037003742 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 391037003743 recombinase A; Provisional; Region: recA; PRK09354 391037003744 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391037003745 hexamer interface [polypeptide binding]; other site 391037003746 Walker A motif; other site 391037003747 ATP binding site [chemical binding]; other site 391037003748 Walker B motif; other site 391037003749 recombination regulator RecX; Reviewed; Region: recX; PRK00117 391037003750 phosphodiesterase; Provisional; Region: PRK12704 391037003751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391037003752 Zn2+ binding site [ion binding]; other site 391037003753 Mg2+ binding site [ion binding]; other site 391037003754 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391037003755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037003756 dimer interface [polypeptide binding]; other site 391037003757 conserved gate region; other site 391037003758 putative PBP binding loops; other site 391037003759 ABC-ATPase subunit interface; other site 391037003760 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391037003761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037003762 dimer interface [polypeptide binding]; other site 391037003763 conserved gate region; other site 391037003764 putative PBP binding loops; other site 391037003765 ABC-ATPase subunit interface; other site 391037003766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391037003767 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391037003768 substrate binding pocket [chemical binding]; other site 391037003769 membrane-bound complex binding site; other site 391037003770 hinge residues; other site 391037003771 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391037003772 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391037003773 Walker A/P-loop; other site 391037003774 ATP binding site [chemical binding]; other site 391037003775 Q-loop/lid; other site 391037003776 ABC transporter signature motif; other site 391037003777 Walker B; other site 391037003778 D-loop; other site 391037003779 H-loop/switch region; other site 391037003780 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 391037003781 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 391037003782 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 391037003783 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 391037003784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037003785 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 391037003786 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391037003787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037003788 FeS/SAM binding site; other site 391037003789 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 391037003790 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 391037003791 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 391037003792 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 391037003793 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 391037003794 IPP transferase; Region: IPPT; pfam01715 391037003795 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 391037003796 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391037003797 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391037003798 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391037003799 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391037003800 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391037003801 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391037003802 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 391037003803 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391037003804 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 391037003805 NAD(P) binding pocket [chemical binding]; other site 391037003806 GTPases [General function prediction only]; Region: HflX; COG2262 391037003807 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 391037003808 HflX GTPase family; Region: HflX; cd01878 391037003809 G1 box; other site 391037003810 GTP/Mg2+ binding site [chemical binding]; other site 391037003811 Switch I region; other site 391037003812 G2 box; other site 391037003813 G3 box; other site 391037003814 Switch II region; other site 391037003815 G4 box; other site 391037003816 G5 box; other site 391037003817 LexA repressor; Validated; Region: PRK00215 391037003818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037003819 putative DNA binding site [nucleotide binding]; other site 391037003820 putative Zn2+ binding site [ion binding]; other site 391037003821 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391037003822 Catalytic site [active] 391037003823 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391037003824 ATP cone domain; Region: ATP-cone; pfam03477 391037003825 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 391037003826 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 391037003827 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391037003828 active site 391037003829 dimer interface [polypeptide binding]; other site 391037003830 effector binding site; other site 391037003831 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391037003832 TSCPD domain; Region: TSCPD; pfam12637 391037003833 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 391037003834 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 391037003835 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 391037003836 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 391037003837 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 391037003838 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391037003839 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 391037003840 FMN binding site [chemical binding]; other site 391037003841 active site 391037003842 substrate binding site [chemical binding]; other site 391037003843 catalytic residue [active] 391037003844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037003845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037003846 beta-lactamase TEM; Provisional; Region: PRK15442 391037003847 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 391037003848 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 391037003849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391037003850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037003851 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391037003852 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391037003853 active site residue [active] 391037003854 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391037003855 active site residue [active] 391037003856 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391037003857 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 391037003858 active site 391037003859 Zn binding site [ion binding]; other site 391037003860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037003861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037003862 Coenzyme A binding pocket [chemical binding]; other site 391037003863 CoA binding domain; Region: CoA_binding_2; pfam13380 391037003864 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 391037003865 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 391037003866 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 391037003867 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391037003868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037003869 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391037003870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037003871 DNA binding residues [nucleotide binding] 391037003872 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 391037003873 active site 391037003874 catalytic triad [active] 391037003875 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 391037003876 PA/protease or protease-like domain interface [polypeptide binding]; other site 391037003877 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 391037003878 putative active site [active] 391037003879 dimerization interface [polypeptide binding]; other site 391037003880 putative tRNAtyr binding site [nucleotide binding]; other site 391037003881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037003882 S-adenosylmethionine binding site [chemical binding]; other site 391037003883 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391037003884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037003885 Walker A/P-loop; other site 391037003886 ATP binding site [chemical binding]; other site 391037003887 Q-loop/lid; other site 391037003888 ABC transporter signature motif; other site 391037003889 Walker B; other site 391037003890 D-loop; other site 391037003891 H-loop/switch region; other site 391037003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037003893 dimer interface [polypeptide binding]; other site 391037003894 conserved gate region; other site 391037003895 putative PBP binding loops; other site 391037003896 ABC-ATPase subunit interface; other site 391037003897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391037003898 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391037003899 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391037003900 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037003901 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 391037003902 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391037003903 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391037003904 substrate binding site [chemical binding]; other site 391037003905 ATP binding site [chemical binding]; other site 391037003906 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 391037003907 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 391037003908 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 391037003909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037003910 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 391037003911 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391037003912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037003913 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391037003914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037003915 DNA binding residues [nucleotide binding] 391037003916 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391037003917 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391037003918 active site 391037003919 dimerization interface [polypeptide binding]; other site 391037003920 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 391037003921 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 391037003922 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 391037003923 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391037003924 trimer interface [polypeptide binding]; other site 391037003925 active site 391037003926 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 391037003927 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391037003928 ssDNA binding site; other site 391037003929 generic binding surface II; other site 391037003930 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 391037003931 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391037003932 TrkA-N domain; Region: TrkA_N; pfam02254 391037003933 TrkA-C domain; Region: TrkA_C; pfam02080 391037003934 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391037003935 TrkA-N domain; Region: TrkA_N; pfam02254 391037003936 TrkA-C domain; Region: TrkA_C; pfam02080 391037003937 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391037003938 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 391037003939 TRAM domain; Region: TRAM; pfam01938 391037003940 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391037003941 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391037003942 TPP-binding site; other site 391037003943 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391037003944 PYR/PP interface [polypeptide binding]; other site 391037003945 dimer interface [polypeptide binding]; other site 391037003946 TPP binding site [chemical binding]; other site 391037003947 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037003948 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 391037003949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037003950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037003951 active site 391037003952 phosphorylation site [posttranslational modification] 391037003953 intermolecular recognition site; other site 391037003954 dimerization interface [polypeptide binding]; other site 391037003955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037003956 DNA binding site [nucleotide binding] 391037003957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037003958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037003959 dimerization interface [polypeptide binding]; other site 391037003960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037003961 dimer interface [polypeptide binding]; other site 391037003962 phosphorylation site [posttranslational modification] 391037003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037003964 ATP binding site [chemical binding]; other site 391037003965 Mg2+ binding site [ion binding]; other site 391037003966 G-X-G motif; other site 391037003967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037003968 Coenzyme A binding pocket [chemical binding]; other site 391037003969 MarR family; Region: MarR_2; cl17246 391037003970 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 391037003971 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 391037003972 CGNR zinc finger; Region: zf-CGNR; pfam11706 391037003973 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 391037003974 active site 391037003975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037003976 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391037003977 substrate binding site [chemical binding]; other site 391037003978 oxyanion hole (OAH) forming residues; other site 391037003979 trimer interface [polypeptide binding]; other site 391037003980 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037003981 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391037003982 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037003983 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 391037003984 dimer interface [polypeptide binding]; other site 391037003985 active site 391037003986 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391037003987 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391037003988 catalytic site [active] 391037003989 putative active site [active] 391037003990 putative substrate binding site [chemical binding]; other site 391037003991 HRDC domain; Region: HRDC; cl02578 391037003992 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391037003993 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391037003994 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 391037003995 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 391037003996 substrate binding site [chemical binding]; other site 391037003997 active site 391037003998 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 391037003999 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 391037004000 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 391037004001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391037004002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037004003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391037004004 dimerization interface [polypeptide binding]; other site 391037004005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037004006 Coenzyme A binding pocket [chemical binding]; other site 391037004007 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391037004008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391037004009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037004010 Chitin binding domain; Region: Chitin_bind_3; pfam03067 391037004011 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 391037004012 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 391037004013 SelR domain; Region: SelR; pfam01641 391037004014 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 391037004015 nucleotide binding site [chemical binding]; other site 391037004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037004017 Coenzyme A binding pocket [chemical binding]; other site 391037004018 TAP-like protein; Region: Abhydrolase_4; pfam08386 391037004019 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 391037004020 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 391037004021 active site 391037004022 DNA binding site [nucleotide binding] 391037004023 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 391037004024 DNA binding site [nucleotide binding] 391037004025 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037004026 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 391037004027 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391037004028 minor groove reading motif; other site 391037004029 helix-hairpin-helix signature motif; other site 391037004030 active site 391037004031 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 391037004032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037004033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 391037004034 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 391037004035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004036 Walker A/P-loop; other site 391037004037 ATP binding site [chemical binding]; other site 391037004038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004039 Q-loop/lid; other site 391037004040 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 391037004041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004042 ABC transporter signature motif; other site 391037004043 Walker B; other site 391037004044 D-loop; other site 391037004045 H-loop/switch region; other site 391037004046 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 391037004047 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 391037004048 active site 391037004049 metal binding site [ion binding]; metal-binding site 391037004050 DNA binding site [nucleotide binding] 391037004051 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 391037004052 HerA helicase [Replication, recombination, and repair]; Region: COG0433 391037004053 hypothetical protein; Provisional; Region: PRK14059 391037004054 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 391037004055 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 391037004056 Caspase domain; Region: Peptidase_C14; pfam00656 391037004057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037004058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037004059 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391037004060 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391037004061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391037004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004063 dimer interface [polypeptide binding]; other site 391037004064 putative PBP binding loops; other site 391037004065 ABC-ATPase subunit interface; other site 391037004066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004068 dimer interface [polypeptide binding]; other site 391037004069 conserved gate region; other site 391037004070 putative PBP binding loops; other site 391037004071 ABC-ATPase subunit interface; other site 391037004072 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391037004073 beta-galactosidase; Region: BGL; TIGR03356 391037004074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037004075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037004076 DNA binding site [nucleotide binding] 391037004077 domain linker motif; other site 391037004078 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 391037004079 putative dimerization interface [polypeptide binding]; other site 391037004080 putative ligand binding site [chemical binding]; other site 391037004081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037004082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037004083 active site 391037004084 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 391037004085 putative active site [active] 391037004086 putative substrate binding site [chemical binding]; other site 391037004087 ATP binding site [chemical binding]; other site 391037004088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037004089 Coenzyme A binding pocket [chemical binding]; other site 391037004090 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037004091 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037004092 NAD(P) binding site [chemical binding]; other site 391037004093 catalytic residues [active] 391037004094 biotin synthase; Validated; Region: PRK06256 391037004095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037004096 FeS/SAM binding site; other site 391037004097 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 391037004098 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 391037004099 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 391037004100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037004101 catalytic residue [active] 391037004102 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 391037004103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037004104 Cytochrome P450; Region: p450; cl12078 391037004105 Predicted methyltransferase [General function prediction only]; Region: COG3897 391037004106 Predicted methyltransferase [General function prediction only]; Region: COG3897 391037004107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037004108 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391037004109 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037004110 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037004111 sugar binding site [chemical binding]; other site 391037004112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037004113 NAD(P) binding site [chemical binding]; other site 391037004114 active site 391037004115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037004116 hypothetical protein; Provisional; Region: PRK07877 391037004117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037004118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004119 active site 391037004120 phosphorylation site [posttranslational modification] 391037004121 intermolecular recognition site; other site 391037004122 dimerization interface [polypeptide binding]; other site 391037004123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037004124 DNA binding residues [nucleotide binding] 391037004125 dimerization interface [polypeptide binding]; other site 391037004126 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391037004127 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 391037004128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 391037004129 Histidine kinase; Region: HisKA_3; pfam07730 391037004130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004131 ATP binding site [chemical binding]; other site 391037004132 Mg2+ binding site [ion binding]; other site 391037004133 G-X-G motif; other site 391037004134 hypothetical protein; Provisional; Region: PRK07877 391037004135 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 391037004136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391037004137 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 391037004138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037004139 Ligand Binding Site [chemical binding]; other site 391037004140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037004141 Ligand Binding Site [chemical binding]; other site 391037004142 putative phosphoketolase; Provisional; Region: PRK05261 391037004143 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 391037004144 TPP-binding site; other site 391037004145 XFP C-terminal domain; Region: XFP_C; pfam09363 391037004146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037004147 Ligand Binding Site [chemical binding]; other site 391037004148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037004149 Ligand Binding Site [chemical binding]; other site 391037004150 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 391037004151 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 391037004152 putative active site [active] 391037004153 putative metal binding site [ion binding]; other site 391037004154 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 391037004155 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037004156 Transcriptional regulator PadR-like family; Region: PadR; cl17335 391037004157 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004158 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004159 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004160 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004161 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004162 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004163 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004165 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004167 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004168 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004169 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004170 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004171 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391037004172 putative hydrophobic ligand binding site [chemical binding]; other site 391037004173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037004174 dimerization interface [polypeptide binding]; other site 391037004175 putative DNA binding site [nucleotide binding]; other site 391037004176 putative Zn2+ binding site [ion binding]; other site 391037004177 TIGR03086 family protein; Region: TIGR03086 391037004178 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 391037004179 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 391037004180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037004181 DivIVA protein; Region: DivIVA; pfam05103 391037004182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037004183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037004184 non-specific DNA binding site [nucleotide binding]; other site 391037004185 salt bridge; other site 391037004186 sequence-specific DNA binding site [nucleotide binding]; other site 391037004187 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037004188 SpoOM protein; Region: Spo0M; pfam07070 391037004189 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 391037004190 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 391037004191 Part of AAA domain; Region: AAA_19; pfam13245 391037004192 Family description; Region: UvrD_C_2; pfam13538 391037004193 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 391037004194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037004195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004196 active site 391037004197 phosphorylation site [posttranslational modification] 391037004198 intermolecular recognition site; other site 391037004199 dimerization interface [polypeptide binding]; other site 391037004200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037004201 DNA binding site [nucleotide binding] 391037004202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037004203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037004204 dimerization interface [polypeptide binding]; other site 391037004205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037004206 dimer interface [polypeptide binding]; other site 391037004207 phosphorylation site [posttranslational modification] 391037004208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004209 ATP binding site [chemical binding]; other site 391037004210 Mg2+ binding site [ion binding]; other site 391037004211 G-X-G motif; other site 391037004212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037004213 Tetratricopeptide repeat; Region: TPR_10; pfam13374 391037004214 YppG-like protein; Region: YppG; pfam14179 391037004215 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391037004216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037004217 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391037004218 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 391037004219 NADP binding site [chemical binding]; other site 391037004220 active site 391037004221 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 391037004222 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 391037004223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037004224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037004225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037004226 DNA binding site [nucleotide binding] 391037004227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037004228 DNA binding site [nucleotide binding] 391037004229 active site 391037004230 Int/Topo IB signature motif; other site 391037004231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037004232 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037004233 metal binding site [ion binding]; metal-binding site 391037004234 active site 391037004235 I-site; other site 391037004236 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037004237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037004238 DNA-binding site [nucleotide binding]; DNA binding site 391037004239 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037004240 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391037004241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037004242 motif II; other site 391037004243 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037004244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037004245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037004246 DNA-binding site [nucleotide binding]; DNA binding site 391037004247 YDG/SRA domain; Region: YDG_SRA; pfam02182 391037004248 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 391037004249 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391037004250 active site 391037004251 Helix-turn-helix domain; Region: HTH_17; cl17695 391037004252 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391037004253 RNA binding site [nucleotide binding]; other site 391037004254 DinB superfamily; Region: DinB_2; pfam12867 391037004255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037004256 Coenzyme A binding pocket [chemical binding]; other site 391037004257 HEAT repeats; Region: HEAT_2; pfam13646 391037004258 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037004259 transposase; Provisional; Region: PRK06526 391037004260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037004261 Walker A motif; other site 391037004262 ATP binding site [chemical binding]; other site 391037004263 Walker B motif; other site 391037004264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037004265 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037004266 DNA-binding interface [nucleotide binding]; DNA binding site 391037004267 Integrase core domain; Region: rve; pfam00665 391037004268 Integrase core domain; Region: rve_3; cl15866 391037004269 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 391037004270 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004271 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004272 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004273 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004274 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004275 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037004276 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004277 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004278 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 391037004279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004280 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 391037004281 Walker A/P-loop; other site 391037004282 ATP binding site [chemical binding]; other site 391037004283 Q-loop/lid; other site 391037004284 ABC transporter signature motif; other site 391037004285 Walker B; other site 391037004286 D-loop; other site 391037004287 H-loop/switch region; other site 391037004288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 391037004289 Histidine kinase; Region: HisKA_3; pfam07730 391037004290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037004291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004292 active site 391037004293 phosphorylation site [posttranslational modification] 391037004294 intermolecular recognition site; other site 391037004295 dimerization interface [polypeptide binding]; other site 391037004296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037004297 DNA binding residues [nucleotide binding] 391037004298 dimerization interface [polypeptide binding]; other site 391037004299 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 391037004300 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 391037004301 active site clefts [active] 391037004302 zinc binding site [ion binding]; other site 391037004303 dimer interface [polypeptide binding]; other site 391037004304 Protein of unknown function (DUF805); Region: DUF805; pfam05656 391037004305 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391037004306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391037004307 phosphate binding site [ion binding]; other site 391037004308 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037004309 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 391037004310 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 391037004311 active site 391037004312 dimer interface [polypeptide binding]; other site 391037004313 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 391037004314 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 391037004315 Ligand Binding Site [chemical binding]; other site 391037004316 Molecular Tunnel; other site 391037004317 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 391037004318 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391037004319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037004320 NAD(P) binding site [chemical binding]; other site 391037004321 active site 391037004322 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 391037004323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004324 dimer interface [polypeptide binding]; other site 391037004325 conserved gate region; other site 391037004326 ABC-ATPase subunit interface; other site 391037004327 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391037004328 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 391037004329 Walker A/P-loop; other site 391037004330 ATP binding site [chemical binding]; other site 391037004331 Q-loop/lid; other site 391037004332 ABC transporter signature motif; other site 391037004333 Walker B; other site 391037004334 D-loop; other site 391037004335 H-loop/switch region; other site 391037004336 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 391037004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004338 ABC-ATPase subunit interface; other site 391037004339 choline dehydrogenase; Validated; Region: PRK02106 391037004340 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391037004341 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 391037004342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037004343 tetramerization interface [polypeptide binding]; other site 391037004344 NAD(P) binding site [chemical binding]; other site 391037004345 catalytic residues [active] 391037004346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004347 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391037004348 Walker A/P-loop; other site 391037004349 ATP binding site [chemical binding]; other site 391037004350 Q-loop/lid; other site 391037004351 ABC transporter signature motif; other site 391037004352 Walker B; other site 391037004353 D-loop; other site 391037004354 H-loop/switch region; other site 391037004355 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 391037004356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004357 dimer interface [polypeptide binding]; other site 391037004358 conserved gate region; other site 391037004359 ABC-ATPase subunit interface; other site 391037004360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004361 dimer interface [polypeptide binding]; other site 391037004362 conserved gate region; other site 391037004363 ABC-ATPase subunit interface; other site 391037004364 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391037004365 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391037004366 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 391037004367 RibD C-terminal domain; Region: RibD_C; cl17279 391037004368 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391037004369 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 391037004370 DNA binding residues [nucleotide binding] 391037004371 high affinity sulphate transporter 1; Region: sulP; TIGR00815 391037004372 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391037004373 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391037004374 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391037004375 Chitin binding domain; Region: Chitin_bind_3; pfam03067 391037004376 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 391037004377 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 391037004378 Domain of unknown function (DUF305); Region: DUF305; cl17794 391037004379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037004380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037004381 DNA binding residues [nucleotide binding] 391037004382 dimerization interface [polypeptide binding]; other site 391037004383 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 391037004384 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 391037004385 nucleotide binding site [chemical binding]; other site 391037004386 putative NEF/HSP70 interaction site [polypeptide binding]; other site 391037004387 SBD interface [polypeptide binding]; other site 391037004388 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391037004389 Dynamin family; Region: Dynamin_N; pfam00350 391037004390 G1 box; other site 391037004391 GTP/Mg2+ binding site [chemical binding]; other site 391037004392 G2 box; other site 391037004393 Switch I region; other site 391037004394 G3 box; other site 391037004395 Switch II region; other site 391037004396 G4 box; other site 391037004397 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 391037004398 Dynamin family; Region: Dynamin_N; pfam00350 391037004399 G1 box; other site 391037004400 GTP/Mg2+ binding site [chemical binding]; other site 391037004401 G2 box; other site 391037004402 Switch I region; other site 391037004403 G3 box; other site 391037004404 Switch II region; other site 391037004405 G4 box; other site 391037004406 G5 box; other site 391037004407 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 391037004408 iron-sulfur cluster [ion binding]; other site 391037004409 [2Fe-2S] cluster binding site [ion binding]; other site 391037004410 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391037004411 cyclase homology domain; Region: CHD; cd07302 391037004412 nucleotidyl binding site; other site 391037004413 metal binding site [ion binding]; metal-binding site 391037004414 dimer interface [polypeptide binding]; other site 391037004415 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391037004416 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391037004417 ligand binding site [chemical binding]; other site 391037004418 flexible hinge region; other site 391037004419 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391037004420 putative switch regulator; other site 391037004421 non-specific DNA interactions [nucleotide binding]; other site 391037004422 DNA binding site [nucleotide binding] 391037004423 sequence specific DNA binding site [nucleotide binding]; other site 391037004424 putative cAMP binding site [chemical binding]; other site 391037004425 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 391037004426 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 391037004427 Homeodomain-like domain; Region: HTH_23; pfam13384 391037004428 Winged helix-turn helix; Region: HTH_29; pfam13551 391037004429 Homeodomain-like domain; Region: HTH_32; pfam13565 391037004430 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037004431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037004432 DDE superfamily endonuclease; Region: DDE_5; pfam13546 391037004433 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391037004434 MULE transposase domain; Region: MULE; pfam10551 391037004435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037004436 non-specific DNA binding site [nucleotide binding]; other site 391037004437 salt bridge; other site 391037004438 sequence-specific DNA binding site [nucleotide binding]; other site 391037004439 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037004440 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037004441 metal binding site [ion binding]; metal-binding site 391037004442 active site 391037004443 I-site; other site 391037004444 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 391037004445 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391037004446 Thioredoxin; Region: Thioredoxin_4; pfam13462 391037004447 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 391037004448 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391037004449 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391037004450 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391037004451 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 391037004452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004454 dimer interface [polypeptide binding]; other site 391037004455 conserved gate region; other site 391037004456 putative PBP binding loops; other site 391037004457 ABC-ATPase subunit interface; other site 391037004458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391037004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037004460 dimer interface [polypeptide binding]; other site 391037004461 conserved gate region; other site 391037004462 putative PBP binding loops; other site 391037004463 ABC-ATPase subunit interface; other site 391037004464 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391037004465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037004466 Walker A/P-loop; other site 391037004467 ATP binding site [chemical binding]; other site 391037004468 Q-loop/lid; other site 391037004469 ABC transporter signature motif; other site 391037004470 Walker B; other site 391037004471 D-loop; other site 391037004472 H-loop/switch region; other site 391037004473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391037004474 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 391037004475 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037004476 Walker A/P-loop; other site 391037004477 ATP binding site [chemical binding]; other site 391037004478 Q-loop/lid; other site 391037004479 ABC transporter signature motif; other site 391037004480 Walker B; other site 391037004481 D-loop; other site 391037004482 H-loop/switch region; other site 391037004483 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391037004484 Cation efflux family; Region: Cation_efflux; cl00316 391037004485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037004486 dimerization interface [polypeptide binding]; other site 391037004487 putative DNA binding site [nucleotide binding]; other site 391037004488 putative Zn2+ binding site [ion binding]; other site 391037004489 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 391037004490 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391037004491 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 391037004492 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 391037004493 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 391037004494 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 391037004495 active site 391037004496 oxyanion hole [active] 391037004497 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391037004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004499 ATP binding site [chemical binding]; other site 391037004500 Mg2+ binding site [ion binding]; other site 391037004501 G-X-G motif; other site 391037004502 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391037004503 anchoring element; other site 391037004504 dimer interface [polypeptide binding]; other site 391037004505 ATP binding site [chemical binding]; other site 391037004506 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391037004507 active site 391037004508 metal binding site [ion binding]; metal-binding site 391037004509 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391037004510 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391037004511 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391037004512 CAP-like domain; other site 391037004513 active site 391037004514 primary dimer interface [polypeptide binding]; other site 391037004515 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391037004516 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 391037004517 putative active site [active] 391037004518 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 391037004519 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391037004520 substrate binding site; other site 391037004521 dimer interface; other site 391037004522 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391037004523 classical (c) SDRs; Region: SDR_c; cd05233 391037004524 NAD(P) binding site [chemical binding]; other site 391037004525 active site 391037004526 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 391037004527 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037004528 Walker A/P-loop; other site 391037004529 ATP binding site [chemical binding]; other site 391037004530 Q-loop/lid; other site 391037004531 ABC transporter signature motif; other site 391037004532 Walker B; other site 391037004533 D-loop; other site 391037004534 H-loop/switch region; other site 391037004535 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391037004536 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391037004537 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037004538 inhibitor-cofactor binding pocket; inhibition site 391037004539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037004540 catalytic residue [active] 391037004541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037004542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037004543 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391037004544 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391037004545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037004546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037004547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391037004548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037004549 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037004550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037004551 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 391037004552 NAD(P) binding site [chemical binding]; other site 391037004553 active site 391037004554 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037004555 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391037004556 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037004557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037004558 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391037004559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391037004560 active site 391037004561 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 391037004562 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037004563 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391037004564 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 391037004565 putative trimer interface [polypeptide binding]; other site 391037004566 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 391037004567 putative CoA binding site [chemical binding]; other site 391037004568 putative trimer interface [polypeptide binding]; other site 391037004569 putative active site [active] 391037004570 putative substrate binding site [chemical binding]; other site 391037004571 putative CoA binding site [chemical binding]; other site 391037004572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037004573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004574 active site 391037004575 dimerization interface [polypeptide binding]; other site 391037004576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037004577 DNA binding site [nucleotide binding] 391037004578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037004579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037004580 dimerization interface [polypeptide binding]; other site 391037004581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037004582 dimer interface [polypeptide binding]; other site 391037004583 phosphorylation site [posttranslational modification] 391037004584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004585 ATP binding site [chemical binding]; other site 391037004586 Mg2+ binding site [ion binding]; other site 391037004587 G-X-G motif; other site 391037004588 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391037004589 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391037004590 Uncharacterized conserved protein [Function unknown]; Region: COG4850 391037004591 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 391037004592 phosphoglucomutase; Validated; Region: PRK07564 391037004593 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 391037004594 active site 391037004595 substrate binding site [chemical binding]; other site 391037004596 metal binding site [ion binding]; metal-binding site 391037004597 ATP-NAD kinase; Region: NAD_kinase; pfam01513 391037004598 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 391037004599 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 391037004600 putative active site [active] 391037004601 Zn binding site [ion binding]; other site 391037004602 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 391037004603 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 391037004604 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 391037004605 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 391037004606 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391037004607 RNA binding site [nucleotide binding]; other site 391037004608 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391037004609 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 391037004610 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 391037004611 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391037004612 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 391037004613 L-aspartate oxidase; Provisional; Region: PRK06175 391037004614 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391037004615 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 391037004616 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 391037004617 putative Iron-sulfur protein interface [polypeptide binding]; other site 391037004618 proximal heme binding site [chemical binding]; other site 391037004619 distal heme binding site [chemical binding]; other site 391037004620 putative dimer interface [polypeptide binding]; other site 391037004621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391037004622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037004623 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391037004624 dimerization interface [polypeptide binding]; other site 391037004625 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 391037004626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037004627 ATP binding site [chemical binding]; other site 391037004628 putative Mg++ binding site [ion binding]; other site 391037004629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037004630 nucleotide binding region [chemical binding]; other site 391037004631 ATP-binding site [chemical binding]; other site 391037004632 Helicase associated domain (HA2); Region: HA2; pfam04408 391037004633 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 391037004634 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 391037004635 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 391037004636 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 391037004637 potential catalytic triad [active] 391037004638 conserved cys residue [active] 391037004639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037004640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037004641 aconitate hydratase-like protein; Provisional; Region: PTZ00092 391037004642 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004643 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004644 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004645 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004646 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004647 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004648 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037004649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037004650 ATP binding site [chemical binding]; other site 391037004651 putative Mg++ binding site [ion binding]; other site 391037004652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037004653 nucleotide binding region [chemical binding]; other site 391037004654 ATP-binding site [chemical binding]; other site 391037004655 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 391037004656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037004657 S-adenosylmethionine binding site [chemical binding]; other site 391037004658 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 391037004659 active site 391037004660 putative catalytic site [active] 391037004661 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391037004662 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391037004663 putative catalytic site [active] 391037004664 putative phosphate binding site [ion binding]; other site 391037004665 active site 391037004666 metal binding site A [ion binding]; metal-binding site 391037004667 DNA binding site [nucleotide binding] 391037004668 putative AP binding site [nucleotide binding]; other site 391037004669 putative metal binding site B [ion binding]; other site 391037004670 PAC2 family; Region: PAC2; pfam09754 391037004671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 391037004672 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037004673 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 391037004674 NAD(P) binding site [chemical binding]; other site 391037004675 catalytic residues [active] 391037004676 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391037004677 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 391037004678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037004679 ATP binding site [chemical binding]; other site 391037004680 putative Mg++ binding site [ion binding]; other site 391037004681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391037004682 Helicase associated domain (HA2); Region: HA2; pfam04408 391037004683 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 391037004684 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037004685 Helix-turn-helix domain; Region: HTH_31; pfam13560 391037004686 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 391037004687 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391037004688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037004689 Coenzyme A binding pocket [chemical binding]; other site 391037004690 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037004691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037004692 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391037004693 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391037004694 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391037004695 homotetramer interface [polypeptide binding]; other site 391037004696 ligand binding site [chemical binding]; other site 391037004697 catalytic site [active] 391037004698 NAD binding site [chemical binding]; other site 391037004699 Conserved TM helix; Region: TM_helix; pfam05552 391037004700 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 391037004701 putative hydrophobic ligand binding site [chemical binding]; other site 391037004702 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 391037004703 ChaB; Region: ChaB; pfam06150 391037004704 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 391037004705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037004706 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 391037004707 NAD(P) binding site [chemical binding]; other site 391037004708 catalytic residues [active] 391037004709 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391037004710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037004711 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391037004712 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 391037004713 Ligand binding site; other site 391037004714 Putative Catalytic site; other site 391037004715 DXD motif; other site 391037004716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037004717 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 391037004718 active site 391037004719 motif I; other site 391037004720 motif II; other site 391037004721 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 391037004722 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 391037004723 putative active site [active] 391037004724 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391037004725 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 391037004726 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 391037004727 putative ADP-binding pocket [chemical binding]; other site 391037004728 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 391037004729 dimer interface [polypeptide binding]; other site 391037004730 active site 391037004731 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391037004732 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 391037004733 substrate binding site [chemical binding]; other site 391037004734 ATP binding site [chemical binding]; other site 391037004735 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 391037004736 active site 391037004737 nucleotide binding site [chemical binding]; other site 391037004738 HIGH motif; other site 391037004739 KMSKS motif; other site 391037004740 classical (c) SDRs; Region: SDR_c; cd05233 391037004741 NAD(P) binding site [chemical binding]; other site 391037004742 active site 391037004743 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 391037004744 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 391037004745 putative active site [active] 391037004746 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 391037004747 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 391037004748 active site 391037004749 DNA binding site [nucleotide binding] 391037004750 Int/Topo IB signature motif; other site 391037004751 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391037004752 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391037004753 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037004754 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037004755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037004756 catalytic residue [active] 391037004757 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391037004758 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391037004759 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 391037004760 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 391037004761 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037004762 DNA-binding site [nucleotide binding]; DNA binding site 391037004763 RNA-binding motif; other site 391037004764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037004765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037004766 active site 391037004767 catalytic tetrad [active] 391037004768 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 391037004769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037004770 S-adenosylmethionine binding site [chemical binding]; other site 391037004771 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 391037004772 adenosine deaminase; Provisional; Region: PRK09358 391037004773 active site 391037004774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037004775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037004776 dimer interface [polypeptide binding]; other site 391037004777 phosphorylation site [posttranslational modification] 391037004778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004779 ATP binding site [chemical binding]; other site 391037004780 Mg2+ binding site [ion binding]; other site 391037004781 G-X-G motif; other site 391037004782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037004783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004784 active site 391037004785 phosphorylation site [posttranslational modification] 391037004786 intermolecular recognition site; other site 391037004787 dimerization interface [polypeptide binding]; other site 391037004788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037004789 DNA binding site [nucleotide binding] 391037004790 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 391037004791 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 391037004792 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 391037004793 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391037004794 active site 391037004795 dimer interface [polypeptide binding]; other site 391037004796 motif 1; other site 391037004797 motif 2; other site 391037004798 motif 3; other site 391037004799 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 391037004800 anticodon binding site; other site 391037004801 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 391037004802 nucleotide binding site/active site [active] 391037004803 HIT family signature motif; other site 391037004804 catalytic residue [active] 391037004805 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 391037004806 elongation factor G; Reviewed; Region: PRK12740 391037004807 G1 box; other site 391037004808 putative GEF interaction site [polypeptide binding]; other site 391037004809 GTP/Mg2+ binding site [chemical binding]; other site 391037004810 Switch I region; other site 391037004811 G2 box; other site 391037004812 G3 box; other site 391037004813 Switch II region; other site 391037004814 G4 box; other site 391037004815 G5 box; other site 391037004816 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391037004817 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391037004818 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391037004819 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 391037004820 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 391037004821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391037004822 putative acyl-acceptor binding pocket; other site 391037004823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037004824 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037004825 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 391037004826 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 391037004827 active site 391037004828 multimer interface [polypeptide binding]; other site 391037004829 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 391037004830 predicted active site [active] 391037004831 catalytic triad [active] 391037004832 hypothetical protein; Validated; Region: PRK00110 391037004833 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 391037004834 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 391037004835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037004836 Walker A/P-loop; other site 391037004837 ATP binding site [chemical binding]; other site 391037004838 Q-loop/lid; other site 391037004839 ABC transporter signature motif; other site 391037004840 Walker B; other site 391037004841 D-loop; other site 391037004842 H-loop/switch region; other site 391037004843 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 391037004844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037004845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037004846 active site 391037004847 phosphorylation site [posttranslational modification] 391037004848 intermolecular recognition site; other site 391037004849 dimerization interface [polypeptide binding]; other site 391037004850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037004851 DNA binding residues [nucleotide binding] 391037004852 dimerization interface [polypeptide binding]; other site 391037004853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 391037004854 Histidine kinase; Region: HisKA_3; pfam07730 391037004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037004856 ATP binding site [chemical binding]; other site 391037004857 Mg2+ binding site [ion binding]; other site 391037004858 G-X-G motif; other site 391037004859 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391037004860 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 391037004861 active site 391037004862 PHP Thumb interface [polypeptide binding]; other site 391037004863 metal binding site [ion binding]; metal-binding site 391037004864 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391037004865 generic binding surface II; other site 391037004866 generic binding surface I; other site 391037004867 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037004868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037004869 catalytic residue [active] 391037004870 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037004871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037004872 sequence-specific DNA binding site [nucleotide binding]; other site 391037004873 salt bridge; other site 391037004874 Thioredoxin; Region: Thioredoxin_4; cl17273 391037004875 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391037004876 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391037004877 Walker A/P-loop; other site 391037004878 ATP binding site [chemical binding]; other site 391037004879 Q-loop/lid; other site 391037004880 ABC transporter signature motif; other site 391037004881 Walker B; other site 391037004882 D-loop; other site 391037004883 H-loop/switch region; other site 391037004884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391037004885 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391037004886 Walker A/P-loop; other site 391037004887 ATP binding site [chemical binding]; other site 391037004888 Q-loop/lid; other site 391037004889 ABC transporter signature motif; other site 391037004890 Walker B; other site 391037004891 D-loop; other site 391037004892 H-loop/switch region; other site 391037004893 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391037004894 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391037004895 putative ligand binding site [chemical binding]; other site 391037004896 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391037004897 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037004898 TM-ABC transporter signature motif; other site 391037004899 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391037004900 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391037004901 TM-ABC transporter signature motif; other site 391037004902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391037004903 GAF domain; Region: GAF; pfam01590 391037004904 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391037004905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037004906 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 391037004907 NAD(P) binding site [chemical binding]; other site 391037004908 active site 391037004909 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 391037004910 active site 391037004911 putative DNA-binding cleft [nucleotide binding]; other site 391037004912 dimer interface [polypeptide binding]; other site 391037004913 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391037004914 RuvA N terminal domain; Region: RuvA_N; pfam01330 391037004915 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391037004916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037004917 Walker A motif; other site 391037004918 ATP binding site [chemical binding]; other site 391037004919 Walker B motif; other site 391037004920 arginine finger; other site 391037004921 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391037004922 Preprotein translocase subunit; Region: YajC; pfam02699 391037004923 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 391037004924 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 391037004925 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 391037004926 Protein export membrane protein; Region: SecD_SecF; pfam02355 391037004927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037004928 active site 391037004929 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391037004930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391037004931 Zn2+ binding site [ion binding]; other site 391037004932 Mg2+ binding site [ion binding]; other site 391037004933 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391037004934 synthetase active site [active] 391037004935 NTP binding site [chemical binding]; other site 391037004936 metal binding site [ion binding]; metal-binding site 391037004937 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391037004938 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 391037004939 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391037004940 active site 391037004941 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391037004942 active site 391037004943 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391037004944 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 391037004945 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 391037004946 dimer interface [polypeptide binding]; other site 391037004947 motif 1; other site 391037004948 active site 391037004949 motif 2; other site 391037004950 motif 3; other site 391037004951 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391037004952 anticodon binding site; other site 391037004953 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 391037004954 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 391037004955 homodimer interface [polypeptide binding]; other site 391037004956 putative substrate binding pocket [chemical binding]; other site 391037004957 diiron center [ion binding]; other site 391037004958 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391037004959 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391037004960 dimer interface [polypeptide binding]; other site 391037004961 anticodon binding site; other site 391037004962 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 391037004963 homodimer interface [polypeptide binding]; other site 391037004964 motif 1; other site 391037004965 active site 391037004966 motif 2; other site 391037004967 GAD domain; Region: GAD; pfam02938 391037004968 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 391037004969 motif 3; other site 391037004970 putative DNA binding site [nucleotide binding]; other site 391037004971 Helix-turn-helix domain; Region: HTH_20; pfam12840 391037004972 dimerization interface [polypeptide binding]; other site 391037004973 putative Zn2+ binding site [ion binding]; other site 391037004974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037004975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037004976 recombination factor protein RarA; Reviewed; Region: PRK13342 391037004977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037004978 Walker A motif; other site 391037004979 ATP binding site [chemical binding]; other site 391037004980 Walker B motif; other site 391037004981 arginine finger; other site 391037004982 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 391037004983 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391037004984 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 391037004985 motif 1; other site 391037004986 active site 391037004987 motif 2; other site 391037004988 motif 3; other site 391037004989 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391037004990 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 391037004991 YceG-like family; Region: YceG; pfam02618 391037004992 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 391037004993 dimerization interface [polypeptide binding]; other site 391037004994 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391037004995 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391037004996 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391037004997 NAD(P) binding site [chemical binding]; other site 391037004998 shikimate binding site; other site 391037004999 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 391037005000 active site 391037005001 trimer interface [polypeptide binding]; other site 391037005002 substrate binding site [chemical binding]; other site 391037005003 CoA binding site [chemical binding]; other site 391037005004 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 391037005005 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 391037005006 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 391037005007 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 391037005008 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391037005009 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 391037005010 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 391037005011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391037005012 active site 391037005013 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037005014 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391037005015 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 391037005016 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 391037005017 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 391037005018 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391037005019 Tetramer interface [polypeptide binding]; other site 391037005020 active site 391037005021 FMN-binding site [chemical binding]; other site 391037005022 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 391037005023 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 391037005024 ADP binding site [chemical binding]; other site 391037005025 magnesium binding site [ion binding]; other site 391037005026 putative shikimate binding site; other site 391037005027 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391037005028 active site 391037005029 dimer interface [polypeptide binding]; other site 391037005030 metal binding site [ion binding]; metal-binding site 391037005031 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391037005032 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391037005033 trimer interface [polypeptide binding]; other site 391037005034 active site 391037005035 dimer interface [polypeptide binding]; other site 391037005036 elongation factor P; Validated; Region: PRK00529 391037005037 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391037005038 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 391037005039 RNA binding site [nucleotide binding]; other site 391037005040 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 391037005041 RNA binding site [nucleotide binding]; other site 391037005042 transcription antitermination factor NusB; Region: nusB; TIGR01951 391037005043 putative RNA binding site [nucleotide binding]; other site 391037005044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037005045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037005046 non-specific DNA binding site [nucleotide binding]; other site 391037005047 salt bridge; other site 391037005048 sequence-specific DNA binding site [nucleotide binding]; other site 391037005049 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 391037005050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037005051 active site 391037005052 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 391037005053 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391037005054 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391037005055 dihydroorotase; Validated; Region: pyrC; PRK09357 391037005056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037005057 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 391037005058 active site 391037005059 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391037005060 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 391037005061 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391037005062 catalytic site [active] 391037005063 subunit interface [polypeptide binding]; other site 391037005064 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391037005065 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037005066 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037005067 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391037005068 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037005069 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037005070 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391037005071 IMP binding site; other site 391037005072 dimer interface [polypeptide binding]; other site 391037005073 interdomain contacts; other site 391037005074 partial ornithine binding site; other site 391037005075 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 391037005076 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 391037005077 quinone interaction residues [chemical binding]; other site 391037005078 active site 391037005079 catalytic residues [active] 391037005080 FMN binding site [chemical binding]; other site 391037005081 substrate binding site [chemical binding]; other site 391037005082 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 391037005083 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037005084 inhibitor-cofactor binding pocket; inhibition site 391037005085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037005086 catalytic residue [active] 391037005087 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 391037005088 active site 391037005089 dimer interface [polypeptide binding]; other site 391037005090 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391037005091 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391037005092 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 391037005093 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391037005094 Flavoprotein; Region: Flavoprotein; pfam02441 391037005095 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 391037005096 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391037005097 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391037005098 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391037005099 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391037005100 primosome assembly protein PriA; Provisional; Region: PRK14873 391037005101 cytidylate kinase; Provisional; Region: PRK04182 391037005102 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391037005103 active site 391037005104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005105 Cytochrome P450; Region: p450; cl12078 391037005106 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391037005107 active site 391037005108 catalytic residues [active] 391037005109 metal binding site [ion binding]; metal-binding site 391037005110 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391037005111 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391037005112 putative active site [active] 391037005113 substrate binding site [chemical binding]; other site 391037005114 putative cosubstrate binding site; other site 391037005115 catalytic site [active] 391037005116 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391037005117 substrate binding site [chemical binding]; other site 391037005118 16S rRNA methyltransferase B; Provisional; Region: PRK14902 391037005119 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 391037005120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005121 S-adenosylmethionine binding site [chemical binding]; other site 391037005122 Septum formation; Region: Septum_form; pfam13845 391037005123 Septum formation; Region: Septum_form; pfam13845 391037005124 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 391037005125 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 391037005126 substrate binding site [chemical binding]; other site 391037005127 hexamer interface [polypeptide binding]; other site 391037005128 metal binding site [ion binding]; metal-binding site 391037005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037005130 active site 391037005131 phosphorylation site [posttranslational modification] 391037005132 intermolecular recognition site; other site 391037005133 dimerization interface [polypeptide binding]; other site 391037005134 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037005135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037005136 metal binding site [ion binding]; metal-binding site 391037005137 active site 391037005138 I-site; other site 391037005139 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 391037005140 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391037005141 catalytic motif [active] 391037005142 Zn binding site [ion binding]; other site 391037005143 RibD C-terminal domain; Region: RibD_C; cl17279 391037005144 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 391037005145 Lumazine binding domain; Region: Lum_binding; pfam00677 391037005146 Lumazine binding domain; Region: Lum_binding; pfam00677 391037005147 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 391037005148 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 391037005149 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 391037005150 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391037005151 dimerization interface [polypeptide binding]; other site 391037005152 active site 391037005153 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 391037005154 homopentamer interface [polypeptide binding]; other site 391037005155 active site 391037005156 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 391037005157 homodimer interface [polypeptide binding]; other site 391037005158 putative metal binding site [ion binding]; other site 391037005159 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 391037005160 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 391037005161 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 391037005162 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 391037005163 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 391037005164 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391037005165 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391037005166 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 391037005167 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391037005168 23S rRNA binding site [nucleotide binding]; other site 391037005169 L21 binding site [polypeptide binding]; other site 391037005170 L13 binding site [polypeptide binding]; other site 391037005171 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391037005172 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 391037005173 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 391037005174 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391037005175 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391037005176 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391037005177 dimer interface [polypeptide binding]; other site 391037005178 motif 1; other site 391037005179 active site 391037005180 motif 2; other site 391037005181 motif 3; other site 391037005182 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391037005183 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391037005184 putative tRNA-binding site [nucleotide binding]; other site 391037005185 B3/4 domain; Region: B3_4; pfam03483 391037005186 tRNA synthetase B5 domain; Region: B5; smart00874 391037005187 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037005188 motif 1; other site 391037005189 dimer interface [polypeptide binding]; other site 391037005190 active site 391037005191 motif 2; other site 391037005192 motif 3; other site 391037005193 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 391037005194 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 391037005195 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391037005196 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 391037005197 heterotetramer interface [polypeptide binding]; other site 391037005198 active site pocket [active] 391037005199 cleavage site 391037005200 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 391037005201 feedback inhibition sensing region; other site 391037005202 homohexameric interface [polypeptide binding]; other site 391037005203 nucleotide binding site [chemical binding]; other site 391037005204 N-acetyl-L-glutamate binding site [chemical binding]; other site 391037005205 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 391037005206 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037005207 inhibitor-cofactor binding pocket; inhibition site 391037005208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037005209 catalytic residue [active] 391037005210 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391037005211 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391037005212 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391037005213 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 391037005214 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 391037005215 argininosuccinate synthase; Provisional; Region: PRK13820 391037005216 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 391037005217 ANP binding site [chemical binding]; other site 391037005218 Substrate Binding Site II [chemical binding]; other site 391037005219 Substrate Binding Site I [chemical binding]; other site 391037005220 argininosuccinate lyase; Provisional; Region: PRK00855 391037005221 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391037005222 active sites [active] 391037005223 tetramer interface [polypeptide binding]; other site 391037005224 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037005225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037005226 CoA binding site [chemical binding]; other site 391037005227 active site 391037005228 AMP binding site [chemical binding]; other site 391037005229 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005230 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 391037005231 active site 391037005232 DNA binding site [nucleotide binding] 391037005233 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037005234 Ligand Binding Site [chemical binding]; other site 391037005235 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037005236 Ligand Binding Site [chemical binding]; other site 391037005237 Universal stress protein family; Region: Usp; pfam00582 391037005238 Ligand Binding Site [chemical binding]; other site 391037005239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037005240 Ligand Binding Site [chemical binding]; other site 391037005241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037005242 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037005243 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391037005244 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 391037005245 CoenzymeA binding site [chemical binding]; other site 391037005246 subunit interaction site [polypeptide binding]; other site 391037005247 PHB binding site; other site 391037005248 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391037005249 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391037005250 active site 391037005251 HIGH motif; other site 391037005252 dimer interface [polypeptide binding]; other site 391037005253 KMSKS motif; other site 391037005254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037005255 RNA binding surface [nucleotide binding]; other site 391037005256 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 391037005257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037005258 active site 391037005259 motif I; other site 391037005260 motif II; other site 391037005261 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391037005262 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391037005263 Uncharacterized conserved protein [Function unknown]; Region: COG3937 391037005264 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 391037005265 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037005266 RNA binding surface [nucleotide binding]; other site 391037005267 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 391037005268 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 391037005269 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 391037005270 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391037005271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037005272 Walker A/P-loop; other site 391037005273 ATP binding site [chemical binding]; other site 391037005274 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391037005275 ABC transporter signature motif; other site 391037005276 Walker B; other site 391037005277 D-loop; other site 391037005278 H-loop/switch region; other site 391037005279 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 391037005280 Thiamine pyrophosphokinase; Region: TPK; cl08415 391037005281 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 391037005282 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391037005283 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037005284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037005285 CTP synthetase; Validated; Region: pyrG; PRK05380 391037005286 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 391037005287 Catalytic site [active] 391037005288 active site 391037005289 UTP binding site [chemical binding]; other site 391037005290 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391037005291 active site 391037005292 putative oxyanion hole; other site 391037005293 catalytic triad [active] 391037005294 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391037005295 dimer interface [polypeptide binding]; other site 391037005296 ADP-ribose binding site [chemical binding]; other site 391037005297 active site 391037005298 nudix motif; other site 391037005299 metal binding site [ion binding]; metal-binding site 391037005300 TM2 domain; Region: TM2; pfam05154 391037005301 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 391037005302 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 391037005303 hexamer interface [polypeptide binding]; other site 391037005304 ligand binding site [chemical binding]; other site 391037005305 putative active site [active] 391037005306 NAD(P) binding site [chemical binding]; other site 391037005307 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391037005308 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037005309 active site 391037005310 DNA binding site [nucleotide binding] 391037005311 Int/Topo IB signature motif; other site 391037005312 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391037005313 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391037005314 P-loop; other site 391037005315 Magnesium ion binding site [ion binding]; other site 391037005316 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391037005317 Magnesium ion binding site [ion binding]; other site 391037005318 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 391037005319 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 391037005320 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391037005321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037005322 RNA binding surface [nucleotide binding]; other site 391037005323 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 391037005324 active site 391037005325 cytidylate kinase; Provisional; Region: cmk; PRK00023 391037005326 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391037005327 CMP-binding site; other site 391037005328 The sites determining sugar specificity; other site 391037005329 GTP-binding protein Der; Reviewed; Region: PRK03003 391037005330 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 391037005331 G1 box; other site 391037005332 GTP/Mg2+ binding site [chemical binding]; other site 391037005333 Switch I region; other site 391037005334 G2 box; other site 391037005335 Switch II region; other site 391037005336 G3 box; other site 391037005337 G4 box; other site 391037005338 G5 box; other site 391037005339 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391037005340 G1 box; other site 391037005341 GTP/Mg2+ binding site [chemical binding]; other site 391037005342 G2 box; other site 391037005343 Switch I region; other site 391037005344 G3 box; other site 391037005345 Switch II region; other site 391037005346 G4 box; other site 391037005347 G5 box; other site 391037005348 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391037005349 active site 391037005350 catalytic residues [active] 391037005351 DNA binding site [nucleotide binding] 391037005352 Int/Topo IB signature motif; other site 391037005353 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037005354 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391037005355 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391037005356 cofactor binding site; other site 391037005357 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 391037005358 polymerase nucleotide-binding site; other site 391037005359 DNA-binding residues [nucleotide binding]; DNA binding site 391037005360 nucleotide binding site [chemical binding]; other site 391037005361 primase nucleotide-binding site [nucleotide binding]; other site 391037005362 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037005363 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037005364 nudix motif; other site 391037005365 Isochorismatase family; Region: Isochorismatase; pfam00857 391037005366 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391037005367 catalytic triad [active] 391037005368 conserved cis-peptide bond; other site 391037005369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391037005370 Nuclease-related domain; Region: NERD; pfam08378 391037005371 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391037005372 Family description; Region: UvrD_C_2; pfam13538 391037005373 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 391037005374 trimer interface [polypeptide binding]; other site 391037005375 putative Zn binding site [ion binding]; other site 391037005376 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 391037005377 active site 391037005378 homotetramer interface [polypeptide binding]; other site 391037005379 homodimer interface [polypeptide binding]; other site 391037005380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037005381 non-specific DNA binding site [nucleotide binding]; other site 391037005382 salt bridge; other site 391037005383 sequence-specific DNA binding site [nucleotide binding]; other site 391037005384 HEXXH motif domain; Region: mod_HExxH; TIGR04267 391037005385 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 391037005386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037005387 FeS/SAM binding site; other site 391037005388 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 391037005389 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 391037005390 NAD binding site [chemical binding]; other site 391037005391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037005392 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037005393 nudix motif; other site 391037005394 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391037005395 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391037005396 active site 391037005397 tetramer interface [polypeptide binding]; other site 391037005398 Mg2+/Mn2+ binding site [ion binding]; other site 391037005399 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 391037005400 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391037005401 active site 391037005402 Helix-turn-helix domain; Region: HTH_31; pfam13560 391037005403 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 391037005404 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391037005405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037005406 Creatinine amidohydrolase; Region: Creatininase; pfam02633 391037005407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037005408 non-specific DNA binding site [nucleotide binding]; other site 391037005409 salt bridge; other site 391037005410 sequence-specific DNA binding site [nucleotide binding]; other site 391037005411 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391037005412 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 391037005413 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 391037005414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037005415 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037005416 DNA-binding interface [nucleotide binding]; DNA binding site 391037005417 Integrase core domain; Region: rve; pfam00665 391037005418 Integrase core domain; Region: rve_3; cl15866 391037005419 transposase; Provisional; Region: PRK06526 391037005420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037005421 Walker A motif; other site 391037005422 ATP binding site [chemical binding]; other site 391037005423 Walker B motif; other site 391037005424 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 391037005425 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 391037005426 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 391037005427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037005428 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 391037005429 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 391037005430 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 391037005431 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 391037005432 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 391037005433 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 391037005434 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 391037005435 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 391037005436 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391037005437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037005438 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391037005439 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 391037005440 putative metal binding site [ion binding]; other site 391037005441 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037005442 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391037005443 Transposase; Region: HTH_Tnp_1; cl17663 391037005444 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391037005445 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 391037005446 ligand binding site [chemical binding]; other site 391037005447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037005448 DDE superfamily endonuclease; Region: DDE_4; pfam13359 391037005449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037005450 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 391037005451 active site 391037005452 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037005453 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037005454 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 391037005455 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 391037005456 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 391037005457 NADP binding site [chemical binding]; other site 391037005458 active site 391037005459 putative substrate binding site [chemical binding]; other site 391037005460 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 391037005461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 391037005462 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037005463 glycosyltransferase, MGT family; Region: MGT; TIGR01426 391037005464 active site 391037005465 TDP-binding site; other site 391037005466 acceptor substrate-binding pocket; other site 391037005467 homodimer interface [polypeptide binding]; other site 391037005468 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 391037005469 putative hydrophobic ligand binding site [chemical binding]; other site 391037005470 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005471 Cytochrome P450; Region: p450; cl12078 391037005472 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037005473 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037005474 Uncharacterized conserved protein [Function unknown]; Region: COG1262 391037005475 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391037005476 O-methyltransferase; Region: Methyltransf_2; pfam00891 391037005477 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037005478 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037005479 active site 391037005480 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037005481 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037005482 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037005483 hypothetical protein; Validated; Region: PRK06840 391037005484 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 391037005485 dimer interface [polypeptide binding]; other site 391037005486 active site 391037005487 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037005488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037005489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005490 Cytochrome P450; Region: p450; cl12078 391037005491 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037005492 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037005493 homodimer interface [polypeptide binding]; other site 391037005494 active site 391037005495 TDP-binding site; other site 391037005496 acceptor substrate-binding pocket; other site 391037005497 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391037005498 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037005499 inhibitor-cofactor binding pocket; inhibition site 391037005500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037005501 catalytic residue [active] 391037005502 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037005503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037005504 active site 391037005505 catalytic tetrad [active] 391037005506 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037005507 glycosyltransferase, MGT family; Region: MGT; TIGR01426 391037005508 active site 391037005509 TDP-binding site; other site 391037005510 acceptor substrate-binding pocket; other site 391037005511 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 391037005512 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391037005513 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391037005514 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037005515 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037005516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037005517 catalytic residue [active] 391037005518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037005519 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 391037005520 Walker A/P-loop; other site 391037005521 ATP binding site [chemical binding]; other site 391037005522 Q-loop/lid; other site 391037005523 ABC transporter signature motif; other site 391037005524 Walker B; other site 391037005525 D-loop; other site 391037005526 H-loop/switch region; other site 391037005527 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037005528 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037005529 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 391037005530 putative hydrophobic ligand binding site [chemical binding]; other site 391037005531 CLM binding site; other site 391037005532 L1 loop; other site 391037005533 DNA binding site [nucleotide binding] 391037005534 Methyltransferase domain; Region: Methyltransf_24; pfam13578 391037005535 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037005536 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037005537 active site 391037005538 TDP-binding site; other site 391037005539 acceptor substrate-binding pocket; other site 391037005540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037005541 dimerization interface [polypeptide binding]; other site 391037005542 putative DNA binding site [nucleotide binding]; other site 391037005543 putative Zn2+ binding site [ion binding]; other site 391037005544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005545 S-adenosylmethionine binding site [chemical binding]; other site 391037005546 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391037005547 catalytic residues [active] 391037005548 catalytic nucleophile [active] 391037005549 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391037005550 Recombinase; Region: Recombinase; pfam07508 391037005551 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391037005552 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 391037005553 active site 391037005554 NTP binding site [chemical binding]; other site 391037005555 metal binding triad [ion binding]; metal-binding site 391037005556 ThiF family; Region: ThiF; pfam00899 391037005557 ATP binding site [chemical binding]; other site 391037005558 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 391037005559 Replication-relaxation; Region: Replic_Relax; pfam13814 391037005560 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 391037005561 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 391037005562 nudix motif; other site 391037005563 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 391037005564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 391037005565 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 391037005566 Penicillin amidase; Region: Penicil_amidase; pfam01804 391037005567 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391037005568 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 391037005569 active site 391037005570 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391037005571 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037005572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037005573 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391037005574 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391037005575 conserved cys residue [active] 391037005576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005578 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391037005579 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391037005580 PYR/PP interface [polypeptide binding]; other site 391037005581 dimer interface [polypeptide binding]; other site 391037005582 TPP binding site [chemical binding]; other site 391037005583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037005584 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391037005585 TPP-binding site [chemical binding]; other site 391037005586 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037005587 active site 391037005588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005589 S-adenosylmethionine binding site [chemical binding]; other site 391037005590 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037005591 Condensation domain; Region: Condensation; pfam00668 391037005592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037005593 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391037005594 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 391037005595 acyl-activating enzyme (AAE) consensus motif; other site 391037005596 AMP binding site [chemical binding]; other site 391037005597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005598 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037005599 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037005600 active site 391037005601 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037005602 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037005603 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 391037005604 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037005605 putative NADP binding site [chemical binding]; other site 391037005606 active site 391037005607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005608 Condensation domain; Region: Condensation; pfam00668 391037005609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037005610 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391037005611 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391037005612 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391037005613 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391037005614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037005615 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391037005616 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391037005617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037005618 Walker A/P-loop; other site 391037005619 ATP binding site [chemical binding]; other site 391037005620 Q-loop/lid; other site 391037005621 ABC transporter signature motif; other site 391037005622 Walker B; other site 391037005623 D-loop; other site 391037005624 H-loop/switch region; other site 391037005625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037005626 Walker A/P-loop; other site 391037005627 ATP binding site [chemical binding]; other site 391037005628 Q-loop/lid; other site 391037005629 ABC transporter signature motif; other site 391037005630 Walker B; other site 391037005631 D-loop; other site 391037005632 H-loop/switch region; other site 391037005633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037005634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005635 S-adenosylmethionine binding site [chemical binding]; other site 391037005636 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037005637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005638 S-adenosylmethionine binding site [chemical binding]; other site 391037005639 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005640 Condensation domain; Region: Condensation; pfam00668 391037005641 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037005642 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391037005643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005644 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391037005645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037005646 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 391037005647 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 391037005648 O-methyltransferase; Region: Methyltransf_2; pfam00891 391037005649 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 391037005650 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391037005651 transmembrane helices; other site 391037005652 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 391037005653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037005654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037005655 Coenzyme A binding pocket [chemical binding]; other site 391037005656 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 391037005657 putative catalytic site [active] 391037005658 metal binding site A [ion binding]; metal-binding site 391037005659 phosphate binding site [ion binding]; other site 391037005660 metal binding site C [ion binding]; metal-binding site 391037005661 metal binding site B [ion binding]; metal-binding site 391037005662 conserved hypothetical protein; Region: TIGR02246 391037005663 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037005664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037005665 active site 391037005666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037005668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005669 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037005670 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391037005671 active sites [active] 391037005672 tetramer interface [polypeptide binding]; other site 391037005673 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037005674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037005675 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037005676 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037005677 acyl-activating enzyme (AAE) consensus motif; other site 391037005678 AMP binding site [chemical binding]; other site 391037005679 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005680 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005681 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 391037005682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005683 S-adenosylmethionine binding site [chemical binding]; other site 391037005684 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 391037005685 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 391037005686 substrate binding site; other site 391037005687 metal-binding site 391037005688 Oligomer interface; other site 391037005689 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 391037005690 putative trimer interface [polypeptide binding]; other site 391037005691 putative CoA binding site [chemical binding]; other site 391037005692 Condensation domain; Region: Condensation; pfam00668 391037005693 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037005694 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 391037005695 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 391037005696 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037005697 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391037005698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037005699 inhibitor-cofactor binding pocket; inhibition site 391037005700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037005701 catalytic residue [active] 391037005702 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 391037005703 Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245 391037005704 NAD binding site [chemical binding]; other site 391037005705 substrate binding site [chemical binding]; other site 391037005706 catalytic Zn binding site [ion binding]; other site 391037005707 structural Zn binding site [ion binding]; other site 391037005708 tetramer interface [polypeptide binding]; other site 391037005709 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005710 Cytochrome P450; Region: p450; cl12078 391037005711 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005712 Cytochrome P450; Region: p450; cl12078 391037005713 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037005714 Cytochrome P450; Region: p450; cl12078 391037005715 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391037005716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037005717 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 391037005718 putative hydrophobic ligand binding site [chemical binding]; other site 391037005719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037005720 dimerization interface [polypeptide binding]; other site 391037005721 putative DNA binding site [nucleotide binding]; other site 391037005722 putative Zn2+ binding site [ion binding]; other site 391037005723 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 391037005724 A new structural DNA glycosylase; Region: AlkD_like; cd06561 391037005725 active site 391037005726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 391037005727 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037005728 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037005729 homodimer interface [polypeptide binding]; other site 391037005730 active site 391037005731 TDP-binding site; other site 391037005732 acceptor substrate-binding pocket; other site 391037005733 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 391037005734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037005735 putative substrate translocation pore; other site 391037005736 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037005737 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 391037005738 NADP binding site [chemical binding]; other site 391037005739 dimer interface [polypeptide binding]; other site 391037005740 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391037005741 putative hydrophobic ligand binding site [chemical binding]; other site 391037005742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037005743 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037005744 NAD(P) binding site [chemical binding]; other site 391037005745 active site 391037005746 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 391037005747 TrkA-N domain; Region: TrkA_N; pfam02254 391037005748 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037005749 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391037005750 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 391037005751 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037005752 Methyltransferase domain; Region: Methyltransf_12; pfam08242 391037005753 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 391037005754 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037005755 Ubiquitin-like proteins; Region: UBQ; cl00155 391037005756 charged pocket; other site 391037005757 hydrophobic patch; other site 391037005758 Uncharacterized conserved protein [Function unknown]; Region: COG1262 391037005759 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391037005760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037005761 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391037005762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037005763 catalytic residue [active] 391037005764 short chain dehydrogenase; Provisional; Region: PRK08303 391037005765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037005766 NAD(P) binding site [chemical binding]; other site 391037005767 active site 391037005768 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 391037005769 Domain of unknown function (DUF385); Region: DUF385; cl04387 391037005770 Hemerythrin-like domain; Region: Hr-like; cd12108 391037005771 Fe binding site [ion binding]; other site 391037005772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037005773 non-specific DNA binding site [nucleotide binding]; other site 391037005774 salt bridge; other site 391037005775 sequence-specific DNA binding site [nucleotide binding]; other site 391037005776 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037005777 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 391037005778 putative active site [active] 391037005779 catalytic site [active] 391037005780 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 391037005781 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 391037005782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037005783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037005784 DNA binding residues [nucleotide binding] 391037005785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037005786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037005787 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391037005788 FAD binding domain; Region: FAD_binding_3; pfam01494 391037005789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037005790 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037005791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037005792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037005793 active site 391037005794 phosphorylation site [posttranslational modification] 391037005795 intermolecular recognition site; other site 391037005796 dimerization interface [polypeptide binding]; other site 391037005797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037005798 DNA binding residues [nucleotide binding] 391037005799 dimerization interface [polypeptide binding]; other site 391037005800 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 391037005801 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 391037005802 Zn binding site [ion binding]; other site 391037005803 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391037005804 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 391037005805 active site 391037005806 NIPSNAP; Region: NIPSNAP; pfam07978 391037005807 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 391037005808 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 391037005809 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391037005810 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391037005811 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391037005812 Amidinotransferase; Region: Amidinotransf; cl12043 391037005813 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 391037005814 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037005815 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 391037005816 active site 391037005817 nucleotide binding site [chemical binding]; other site 391037005818 HIGH motif; other site 391037005819 KMSKS motif; other site 391037005820 Cupin domain; Region: Cupin_2; pfam07883 391037005821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037005822 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 391037005823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037005824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037005825 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 391037005826 Acid Phosphatase; Region: Acid_PPase; cl17256 391037005827 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037005828 active site 391037005829 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391037005830 active site 391037005831 hypothetical protein; Provisional; Region: PRK07907 391037005832 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 391037005833 active site 391037005834 metal binding site [ion binding]; metal-binding site 391037005835 dimer interface [polypeptide binding]; other site 391037005836 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 391037005837 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391037005838 conserved cys residue [active] 391037005839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005841 putative transporter; Provisional; Region: PRK11021 391037005842 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391037005843 metal binding site 2 [ion binding]; metal-binding site 391037005844 putative DNA binding helix; other site 391037005845 metal binding site 1 [ion binding]; metal-binding site 391037005846 dimer interface [polypeptide binding]; other site 391037005847 structural Zn2+ binding site [ion binding]; other site 391037005848 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391037005849 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391037005850 heme binding site [chemical binding]; other site 391037005851 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 391037005852 hypothetical protein; Provisional; Region: PRK08244 391037005853 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037005854 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037005855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037005856 dimerization interface [polypeptide binding]; other site 391037005857 putative DNA binding site [nucleotide binding]; other site 391037005858 putative Zn2+ binding site [ion binding]; other site 391037005859 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 391037005860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005861 S-adenosylmethionine binding site [chemical binding]; other site 391037005862 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 391037005863 putative hydrophobic ligand binding site [chemical binding]; other site 391037005864 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391037005865 B12 binding site [chemical binding]; other site 391037005866 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 391037005867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037005868 FeS/SAM binding site; other site 391037005869 Ubiquitin-like proteins; Region: UBQ; cl00155 391037005870 charged pocket; other site 391037005871 hydrophobic patch; other site 391037005872 O-methyltransferase; Region: Methyltransf_2; pfam00891 391037005873 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 391037005874 peptide binding site [polypeptide binding]; other site 391037005875 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391037005876 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037005877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037005878 NAD(P) binding site [chemical binding]; other site 391037005879 active site 391037005880 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 391037005881 TrkA-N domain; Region: TrkA_N; pfam02254 391037005882 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391037005883 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391037005884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037005886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005887 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 391037005888 Family description; Region: VCBS; pfam13517 391037005889 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 391037005890 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037005891 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037005892 active site 391037005893 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037005894 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 391037005895 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037005896 putative NADP binding site [chemical binding]; other site 391037005897 active site 391037005898 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037005899 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391037005900 active site 391037005901 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391037005902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037005903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037005904 catalytic residue [active] 391037005905 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 391037005906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037005907 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 391037005908 active site 391037005909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005910 S-adenosylmethionine binding site [chemical binding]; other site 391037005911 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037005912 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391037005913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037005914 catalytic residue [active] 391037005915 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391037005916 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391037005917 Clp protease ATP binding subunit; Region: clpC; CHL00095 391037005918 Clp amino terminal domain; Region: Clp_N; pfam02861 391037005919 Clp amino terminal domain; Region: Clp_N; pfam02861 391037005920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037005921 Walker A motif; other site 391037005922 ATP binding site [chemical binding]; other site 391037005923 Walker B motif; other site 391037005924 arginine finger; other site 391037005925 UvrB/uvrC motif; Region: UVR; pfam02151 391037005926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037005927 Walker A motif; other site 391037005928 ATP binding site [chemical binding]; other site 391037005929 Walker B motif; other site 391037005930 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391037005931 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391037005932 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391037005933 ABC1 family; Region: ABC1; cl17513 391037005934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037005935 S-adenosylmethionine binding site [chemical binding]; other site 391037005936 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 391037005937 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391037005938 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037005939 AAA ATPase domain; Region: AAA_16; pfam13191 391037005940 Predicted ATPase [General function prediction only]; Region: COG3903 391037005941 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 391037005942 Predicted transcriptional regulators [Transcription]; Region: COG1733 391037005943 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 391037005944 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 391037005945 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391037005946 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 391037005947 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 391037005948 heme binding pocket [chemical binding]; other site 391037005949 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 391037005950 domain interactions; other site 391037005951 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037005952 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391037005953 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391037005954 short chain dehydrogenase; Validated; Region: PRK08264 391037005955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037005956 NAD(P) binding site [chemical binding]; other site 391037005957 active site 391037005958 Cupin; Region: Cupin_6; pfam12852 391037005959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037005960 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037005961 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 391037005962 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 391037005963 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 391037005964 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037005965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037005966 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037005967 DNA-binding site [nucleotide binding]; DNA binding site 391037005968 RNA-binding motif; other site 391037005969 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391037005970 metal ion-dependent adhesion site (MIDAS); other site 391037005971 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391037005972 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 391037005973 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391037005974 FAD binding pocket [chemical binding]; other site 391037005975 FAD binding motif [chemical binding]; other site 391037005976 phosphate binding motif [ion binding]; other site 391037005977 beta-alpha-beta structure motif; other site 391037005978 NAD binding pocket [chemical binding]; other site 391037005979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037005980 catalytic loop [active] 391037005981 iron binding site [ion binding]; other site 391037005982 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 391037005983 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 391037005984 putative di-iron ligands [ion binding]; other site 391037005985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 391037005986 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 391037005987 acyl-activating enzyme (AAE) consensus motif; other site 391037005988 putative AMP binding site [chemical binding]; other site 391037005989 putative active site [active] 391037005990 putative CoA binding site [chemical binding]; other site 391037005991 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391037005992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037005993 active site residue [active] 391037005994 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 391037005995 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391037005996 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037005997 active site residue [active] 391037005998 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 391037005999 putative homotetramer interface [polypeptide binding]; other site 391037006000 putative homodimer interface [polypeptide binding]; other site 391037006001 putative allosteric switch controlling residues; other site 391037006002 putative metal binding site [ion binding]; other site 391037006003 Protein of unknown function (DUF998); Region: DUF998; pfam06197 391037006004 Protein of unknown function (DUF690); Region: DUF690; cl04939 391037006005 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 391037006006 active site 391037006007 catalytic site [active] 391037006008 Zn binding site [ion binding]; other site 391037006009 tetramer interface [polypeptide binding]; other site 391037006010 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391037006011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037006012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037006013 metal binding site [ion binding]; metal-binding site 391037006014 active site 391037006015 I-site; other site 391037006016 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037006017 Helix-turn-helix domain; Region: HTH_31; pfam13560 391037006018 non-specific DNA binding site [nucleotide binding]; other site 391037006019 salt bridge; other site 391037006020 sequence-specific DNA binding site [nucleotide binding]; other site 391037006021 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391037006022 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391037006023 serine hydroxymethyltransferase; Provisional; Region: PRK13580 391037006024 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391037006025 dimer interface [polypeptide binding]; other site 391037006026 active site 391037006027 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391037006028 folate binding site [chemical binding]; other site 391037006029 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391037006030 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 391037006031 active site 391037006032 metal binding site [ion binding]; metal-binding site 391037006033 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391037006034 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 391037006035 nucleotide binding site [chemical binding]; other site 391037006036 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037006037 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391037006038 putative DNA binding site [nucleotide binding]; other site 391037006039 putative Zn2+ binding site [ion binding]; other site 391037006040 AsnC family; Region: AsnC_trans_reg; pfam01037 391037006041 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 391037006042 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391037006043 tetramer interface [polypeptide binding]; other site 391037006044 TPP-binding site [chemical binding]; other site 391037006045 heterodimer interface [polypeptide binding]; other site 391037006046 phosphorylation loop region [posttranslational modification] 391037006047 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391037006048 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391037006049 alpha subunit interface [polypeptide binding]; other site 391037006050 TPP binding site [chemical binding]; other site 391037006051 heterodimer interface [polypeptide binding]; other site 391037006052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037006053 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 391037006054 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037006055 E3 interaction surface; other site 391037006056 lipoyl attachment site [posttranslational modification]; other site 391037006057 e3 binding domain; Region: E3_binding; pfam02817 391037006058 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391037006059 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 391037006060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391037006061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391037006062 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037006063 anti sigma factor interaction site; other site 391037006064 regulatory phosphorylation site [posttranslational modification]; other site 391037006065 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391037006066 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391037006067 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 391037006068 intersubunit interface [polypeptide binding]; other site 391037006069 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 391037006070 FMN binding site [chemical binding]; other site 391037006071 dimer interface [polypeptide binding]; other site 391037006072 Lsr2; Region: Lsr2; pfam11774 391037006073 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391037006074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006075 Walker A motif; other site 391037006076 ATP binding site [chemical binding]; other site 391037006077 Walker B motif; other site 391037006078 arginine finger; other site 391037006079 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391037006080 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391037006081 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391037006082 ATP binding site [chemical binding]; other site 391037006083 Mg++ binding site [ion binding]; other site 391037006084 motif III; other site 391037006085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037006086 nucleotide binding region [chemical binding]; other site 391037006087 ATP-binding site [chemical binding]; other site 391037006088 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 391037006089 RNA binding site [nucleotide binding]; other site 391037006090 LVIVD repeat; Region: LVIVD; pfam08309 391037006091 Domain of unknown function (DUF305); Region: DUF305; pfam03713 391037006092 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037006093 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391037006094 active site 391037006095 ATP binding site [chemical binding]; other site 391037006096 substrate binding site [chemical binding]; other site 391037006097 activation loop (A-loop); other site 391037006098 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 391037006099 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 391037006100 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391037006101 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 391037006102 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 391037006103 putative active site [active] 391037006104 putative dimer interface [polypeptide binding]; other site 391037006105 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 391037006106 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 391037006107 Predicted membrane protein [Function unknown]; Region: COG2119 391037006108 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 391037006109 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 391037006110 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 391037006111 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 391037006112 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 391037006113 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 391037006114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391037006115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391037006116 Integral membrane protein TerC family; Region: TerC; cl10468 391037006117 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 391037006118 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391037006119 Moco binding site; other site 391037006120 metal coordination site [ion binding]; other site 391037006121 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 391037006122 FAD binding pocket [chemical binding]; other site 391037006123 conserved FAD binding motif [chemical binding]; other site 391037006124 phosphate binding motif [ion binding]; other site 391037006125 beta-alpha-beta structure motif; other site 391037006126 NAD binding pocket [chemical binding]; other site 391037006127 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 391037006128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037006129 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 391037006130 OsmC-like protein; Region: OsmC; cl00767 391037006131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037006132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037006133 active site 391037006134 phosphorylation site [posttranslational modification] 391037006135 intermolecular recognition site; other site 391037006136 dimerization interface [polypeptide binding]; other site 391037006137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037006138 DNA binding site [nucleotide binding] 391037006139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037006140 HAMP domain; Region: HAMP; pfam00672 391037006141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037006142 dimer interface [polypeptide binding]; other site 391037006143 phosphorylation site [posttranslational modification] 391037006144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037006145 ATP binding site [chemical binding]; other site 391037006146 Mg2+ binding site [ion binding]; other site 391037006147 G-X-G motif; other site 391037006148 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 391037006149 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 391037006150 Ligand binding site; other site 391037006151 Ligand binding site; other site 391037006152 Ligand binding site; other site 391037006153 Putative Catalytic site; other site 391037006154 DXD motif; other site 391037006155 GtrA-like protein; Region: GtrA; pfam04138 391037006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006157 S-adenosylmethionine binding site [chemical binding]; other site 391037006158 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 391037006159 Sulfatase; Region: Sulfatase; cl17466 391037006160 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391037006161 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391037006162 dimer interface [polypeptide binding]; other site 391037006163 active site 391037006164 citrylCoA binding site [chemical binding]; other site 391037006165 NADH binding [chemical binding]; other site 391037006166 cationic pore residues; other site 391037006167 oxalacetate/citrate binding site [chemical binding]; other site 391037006168 coenzyme A binding site [chemical binding]; other site 391037006169 catalytic triad [active] 391037006170 Homeodomain-like domain; Region: HTH_23; pfam13384 391037006171 Winged helix-turn helix; Region: HTH_29; pfam13551 391037006172 Homeodomain-like domain; Region: HTH_32; pfam13565 391037006173 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037006174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037006175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037006176 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037006177 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037006178 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 391037006179 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 391037006180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037006181 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391037006182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037006183 DNA binding residues [nucleotide binding] 391037006184 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 391037006185 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 391037006186 D-pathway; other site 391037006187 Putative ubiquinol binding site [chemical binding]; other site 391037006188 Low-spin heme (heme b) binding site [chemical binding]; other site 391037006189 Putative water exit pathway; other site 391037006190 Binuclear center (heme o3/CuB) [ion binding]; other site 391037006191 K-pathway; other site 391037006192 Putative proton exit pathway; other site 391037006193 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 391037006194 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391037006195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391037006196 nucleotide binding region [chemical binding]; other site 391037006197 ATP-binding site [chemical binding]; other site 391037006198 GAF domain; Region: GAF_2; pfam13185 391037006199 ANTAR domain; Region: ANTAR; pfam03861 391037006200 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 391037006201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037006202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037006203 DNA binding site [nucleotide binding] 391037006204 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 391037006205 Cupin superfamily protein; Region: Cupin_4; pfam08007 391037006206 Cupin-like domain; Region: Cupin_8; pfam13621 391037006207 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037006208 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 391037006209 Clp amino terminal domain; Region: Clp_N; pfam02861 391037006210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006211 Walker A motif; other site 391037006212 ATP binding site [chemical binding]; other site 391037006213 Walker B motif; other site 391037006214 arginine finger; other site 391037006215 UvrB/uvrC motif; Region: UVR; pfam02151 391037006216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006217 Walker A motif; other site 391037006218 ATP binding site [chemical binding]; other site 391037006219 Walker B motif; other site 391037006220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391037006221 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 391037006222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391037006223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037006224 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 391037006225 substrate binding pocket [chemical binding]; other site 391037006226 dimerization interface [polypeptide binding]; other site 391037006227 hypothetical protein; Provisional; Region: PRK07906 391037006228 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 391037006229 putative metal binding site [ion binding]; other site 391037006230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037006231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037006232 active site 391037006233 catalytic tetrad [active] 391037006234 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 391037006235 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 391037006236 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 391037006237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037006238 catalytic core [active] 391037006239 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 391037006240 conserved hypothetical protein; Region: TIGR03843 391037006241 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 391037006242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037006243 active site 391037006244 HIGH motif; other site 391037006245 nucleotide binding site [chemical binding]; other site 391037006246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037006247 active site 391037006248 KMSKS motif; other site 391037006249 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 391037006250 putative tRNA binding surface [nucleotide binding]; other site 391037006251 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037006252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037006253 DNA-binding site [nucleotide binding]; DNA binding site 391037006254 UTRA domain; Region: UTRA; pfam07702 391037006255 PAC2 family; Region: PAC2; pfam09754 391037006256 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 391037006257 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 391037006258 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 391037006259 substrate binding pocket [chemical binding]; other site 391037006260 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 391037006261 B12 binding site [chemical binding]; other site 391037006262 cobalt ligand [ion binding]; other site 391037006263 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 391037006264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037006265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037006266 DNA binding residues [nucleotide binding] 391037006267 dimerization interface [polypeptide binding]; other site 391037006268 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037006269 Cytochrome P450; Region: p450; cl12078 391037006270 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037006271 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037006272 active site 391037006273 TDP-binding site; other site 391037006274 acceptor substrate-binding pocket; other site 391037006275 homodimer interface [polypeptide binding]; other site 391037006276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037006277 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391037006278 Ferritin-like; Region: Ferritin-like; pfam12902 391037006279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037006280 Cytochrome P450; Region: p450; cl12078 391037006281 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037006282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006283 S-adenosylmethionine binding site [chemical binding]; other site 391037006284 hypothetical protein; Provisional; Region: PRK06126 391037006285 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037006286 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 391037006287 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 391037006288 substrate binding site; other site 391037006289 tetramer interface; other site 391037006290 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 391037006291 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 391037006292 NAD binding site [chemical binding]; other site 391037006293 substrate binding site [chemical binding]; other site 391037006294 homodimer interface [polypeptide binding]; other site 391037006295 active site 391037006296 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391037006297 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037006298 inhibitor-cofactor binding pocket; inhibition site 391037006299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037006300 catalytic residue [active] 391037006301 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 391037006302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037006303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037006304 NAD(P) binding site [chemical binding]; other site 391037006305 extended (e) SDRs; Region: SDR_e; cd08946 391037006306 NAD(P) binding site [chemical binding]; other site 391037006307 active site 391037006308 substrate binding site [chemical binding]; other site 391037006309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037006310 active site 391037006311 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037006312 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 391037006313 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037006314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037006315 catalytic residue [active] 391037006316 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 391037006317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006319 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 391037006320 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391037006321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037006322 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 391037006323 putative active site [active] 391037006324 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037006325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037006326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006327 putative substrate translocation pore; other site 391037006328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006329 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 391037006330 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391037006331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037006332 motif II; other site 391037006333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391037006334 FtsX-like permease family; Region: FtsX; pfam02687 391037006335 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391037006336 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391037006337 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391037006338 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391037006339 Walker A/P-loop; other site 391037006340 ATP binding site [chemical binding]; other site 391037006341 Q-loop/lid; other site 391037006342 ABC transporter signature motif; other site 391037006343 Walker B; other site 391037006344 D-loop; other site 391037006345 H-loop/switch region; other site 391037006346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037006347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 391037006348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037006349 phosphorylation site [posttranslational modification] 391037006350 intermolecular recognition site; other site 391037006351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037006352 DNA binding residues [nucleotide binding] 391037006353 dimerization interface [polypeptide binding]; other site 391037006354 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391037006355 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391037006356 active site 391037006357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391037006358 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 391037006359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006360 S-adenosylmethionine binding site [chemical binding]; other site 391037006361 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 391037006362 proteasome ATPase; Region: pup_AAA; TIGR03689 391037006363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006364 Walker A motif; other site 391037006365 ATP binding site [chemical binding]; other site 391037006366 Walker B motif; other site 391037006367 arginine finger; other site 391037006368 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 391037006369 Pup-like protein; Region: Pup; pfam05639 391037006370 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 391037006371 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 391037006372 active site 391037006373 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 391037006374 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 391037006375 active site 391037006376 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 391037006377 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 391037006378 NAD binding site [chemical binding]; other site 391037006379 substrate binding site [chemical binding]; other site 391037006380 homodimer interface [polypeptide binding]; other site 391037006381 active site 391037006382 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 391037006383 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 391037006384 Predicted transcriptional regulator [Transcription]; Region: COG2378 391037006385 WYL domain; Region: WYL; pfam13280 391037006386 Predicted transcriptional regulator [Transcription]; Region: COG2378 391037006387 WYL domain; Region: WYL; pfam13280 391037006388 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 391037006389 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 391037006390 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 391037006391 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 391037006392 diacylglycerol kinase; Reviewed; Region: PRK11914 391037006393 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037006394 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 391037006395 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 391037006396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037006397 ATP binding site [chemical binding]; other site 391037006398 putative Mg++ binding site [ion binding]; other site 391037006399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037006400 nucleotide binding region [chemical binding]; other site 391037006401 ATP-binding site [chemical binding]; other site 391037006402 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 391037006403 5'-3' exonuclease; Region: 53EXOc; smart00475 391037006404 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391037006405 active site 391037006406 metal binding site 1 [ion binding]; metal-binding site 391037006407 putative 5' ssDNA interaction site; other site 391037006408 metal binding site 3; metal-binding site 391037006409 metal binding site 2 [ion binding]; metal-binding site 391037006410 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391037006411 putative DNA binding site [nucleotide binding]; other site 391037006412 putative metal binding site [ion binding]; other site 391037006413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391037006414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391037006415 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 391037006416 active site 391037006417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037006418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037006419 active site 391037006420 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391037006421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037006422 putative DNA binding site [nucleotide binding]; other site 391037006423 putative Zn2+ binding site [ion binding]; other site 391037006424 AsnC family; Region: AsnC_trans_reg; pfam01037 391037006425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037006426 catalytic core [active] 391037006427 CsbD-like; Region: CsbD; cl17424 391037006428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 391037006429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037006430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037006431 active site 391037006432 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 391037006433 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391037006434 B12 binding site [chemical binding]; other site 391037006435 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037006436 active site 2 [active] 391037006437 MutL protein; Region: MutL; pfam13941 391037006438 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 391037006439 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391037006440 putative active site [active] 391037006441 catalytic triad [active] 391037006442 putative dimer interface [polypeptide binding]; other site 391037006443 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391037006444 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 391037006445 Ligand binding site; other site 391037006446 Putative Catalytic site; other site 391037006447 DXD motif; other site 391037006448 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 391037006449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037006450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037006451 Coenzyme A binding pocket [chemical binding]; other site 391037006452 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006454 S-adenosylmethionine binding site [chemical binding]; other site 391037006455 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 391037006456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037006457 dimerization interface [polypeptide binding]; other site 391037006458 putative DNA binding site [nucleotide binding]; other site 391037006459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037006460 putative Zn2+ binding site [ion binding]; other site 391037006461 AsnC family; Region: AsnC_trans_reg; pfam01037 391037006462 hypothetical protein; Provisional; Region: PRK14059 391037006463 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 391037006464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006465 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391037006466 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037006467 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 391037006468 putative NAD(P) binding site [chemical binding]; other site 391037006469 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 391037006470 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391037006471 Walker A/P-loop; other site 391037006472 ATP binding site [chemical binding]; other site 391037006473 Q-loop/lid; other site 391037006474 ABC transporter signature motif; other site 391037006475 Walker B; other site 391037006476 D-loop; other site 391037006477 H-loop/switch region; other site 391037006478 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391037006479 ABC-ATPase subunit interface; other site 391037006480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037006481 dimer interface [polypeptide binding]; other site 391037006482 putative PBP binding regions; other site 391037006483 ABC-ATPase subunit interface; other site 391037006484 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 391037006485 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 391037006486 putative ligand binding residues [chemical binding]; other site 391037006487 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037006488 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037006489 active site 391037006490 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037006491 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037006492 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 391037006493 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037006494 putative NADP binding site [chemical binding]; other site 391037006495 active site 391037006496 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037006497 Condensation domain; Region: Condensation; pfam00668 391037006498 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037006499 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037006500 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037006501 acyl-activating enzyme (AAE) consensus motif; other site 391037006502 AMP binding site [chemical binding]; other site 391037006503 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037006504 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391037006505 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391037006506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037006507 Prostaglandin dehydrogenases; Region: PGDH; cd05288 391037006508 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 391037006509 NAD(P) binding site [chemical binding]; other site 391037006510 substrate binding site [chemical binding]; other site 391037006511 dimer interface [polypeptide binding]; other site 391037006512 CBD_II domain; Region: CBD_II; smart00637 391037006513 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 391037006514 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 391037006515 short chain dehydrogenase; Provisional; Region: PRK08303 391037006516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037006517 NAD(P) binding site [chemical binding]; other site 391037006518 active site 391037006519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037006520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006521 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391037006522 Beta-lactamase; Region: Beta-lactamase; pfam00144 391037006523 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 391037006524 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 391037006525 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037006526 DNA binding residues [nucleotide binding] 391037006527 drug binding residues [chemical binding]; other site 391037006528 dimer interface [polypeptide binding]; other site 391037006529 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391037006530 Protein phosphatase 2C; Region: PP2C; pfam00481 391037006531 active site 391037006532 Erythromycin esterase; Region: Erythro_esteras; pfam05139 391037006533 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 391037006534 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037006535 DNA binding residues [nucleotide binding] 391037006536 putative dimer interface [polypeptide binding]; other site 391037006537 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 391037006538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037006539 DNA binding residues [nucleotide binding] 391037006540 putative dimer interface [polypeptide binding]; other site 391037006541 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 391037006542 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 391037006543 HTH domain; Region: HTH_11; pfam08279 391037006544 WYL domain; Region: WYL; pfam13280 391037006545 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391037006546 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391037006547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037006548 non-specific DNA binding site [nucleotide binding]; other site 391037006549 salt bridge; other site 391037006550 sequence-specific DNA binding site [nucleotide binding]; other site 391037006551 Cupin domain; Region: Cupin_2; pfam07883 391037006552 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 391037006553 nudix motif; other site 391037006554 Predicted transcriptional regulators [Transcription]; Region: COG1733 391037006555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037006556 dimerization interface [polypeptide binding]; other site 391037006557 putative DNA binding site [nucleotide binding]; other site 391037006558 putative Zn2+ binding site [ion binding]; other site 391037006559 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391037006560 homotrimer interaction site [polypeptide binding]; other site 391037006561 putative active site [active] 391037006562 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037006563 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 391037006564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391037006566 Walker A/P-loop; other site 391037006567 ATP binding site [chemical binding]; other site 391037006568 Q-loop/lid; other site 391037006569 ABC transporter signature motif; other site 391037006570 Walker B; other site 391037006571 D-loop; other site 391037006572 H-loop/switch region; other site 391037006573 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037006574 FAD binding domain; Region: FAD_binding_4; pfam01565 391037006575 Berberine and berberine like; Region: BBE; pfam08031 391037006576 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 391037006577 Protein phosphatase 2C; Region: PP2C; pfam00481 391037006578 active site 391037006579 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 391037006580 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 391037006581 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 391037006582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037006583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037006584 homodimer interface [polypeptide binding]; other site 391037006585 catalytic residue [active] 391037006586 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 391037006587 amphipathic channel; other site 391037006588 Asn-Pro-Ala signature motifs; other site 391037006589 MarR family; Region: MarR_2; pfam12802 391037006590 Restriction endonuclease; Region: Mrr_cat; pfam04471 391037006591 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 391037006592 Uncharacterized conserved protein [Function unknown]; Region: COG1434 391037006593 putative active site [active] 391037006594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037006595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037006596 non-specific DNA binding site [nucleotide binding]; other site 391037006597 salt bridge; other site 391037006598 sequence-specific DNA binding site [nucleotide binding]; other site 391037006599 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 391037006600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037006601 FeS/SAM binding site; other site 391037006602 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037006603 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037006604 hypothetical protein; Provisional; Region: PRK06762 391037006605 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 391037006606 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 391037006607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037006608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006609 Protein of unknown function, DUF393; Region: DUF393; cl01136 391037006610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037006611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006612 putative substrate translocation pore; other site 391037006613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037006615 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 391037006616 active site 391037006617 DNA binding site [nucleotide binding] 391037006618 Int/Topo IB signature motif; other site 391037006619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006620 Walker A/P-loop; other site 391037006621 ATP binding site [chemical binding]; other site 391037006622 Q-loop/lid; other site 391037006623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006624 ABC transporter signature motif; other site 391037006625 Walker B; other site 391037006626 D-loop; other site 391037006627 H-loop/switch region; other site 391037006628 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 391037006629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006630 Walker A/P-loop; other site 391037006631 ATP binding site [chemical binding]; other site 391037006632 Q-loop/lid; other site 391037006633 ABC transporter signature motif; other site 391037006634 Walker B; other site 391037006635 D-loop; other site 391037006636 H-loop/switch region; other site 391037006637 glucose-1-dehydrogenase; Provisional; Region: PRK06947 391037006638 classical (c) SDRs; Region: SDR_c; cd05233 391037006639 NAD(P) binding site [chemical binding]; other site 391037006640 active site 391037006641 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 391037006642 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 391037006643 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 391037006644 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 391037006645 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 391037006646 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 391037006647 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037006648 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391037006649 putative acyl-acceptor binding pocket; other site 391037006650 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 391037006651 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 391037006652 putative active site [active] 391037006653 catalytic site [active] 391037006654 putative metal binding site [ion binding]; other site 391037006655 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 391037006656 thymidine kinase; Provisional; Region: PRK04296 391037006657 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037006658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037006659 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391037006660 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 391037006661 active site 391037006662 NAD binding site [chemical binding]; other site 391037006663 metal binding site [ion binding]; metal-binding site 391037006664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391037006665 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037006666 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 391037006667 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 391037006668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037006669 active site 391037006670 Int/Topo IB signature motif; other site 391037006671 DNA binding site [nucleotide binding] 391037006672 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006673 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391037006674 MarR family; Region: MarR; pfam01047 391037006675 MarR family; Region: MarR_2; cl17246 391037006676 Predicted flavoprotein [General function prediction only]; Region: COG0431 391037006677 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391037006678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037006679 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391037006680 Coenzyme A binding pocket [chemical binding]; other site 391037006681 GYD domain; Region: GYD; pfam08734 391037006682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037006683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006684 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391037006685 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037006686 Repeat of unknown function (DUF346); Region: DUF346; pfam03984 391037006687 Repeat of unknown function (DUF346); Region: DUF346; pfam03984 391037006688 Repeat of unknown function (DUF346); Region: DUF346; pfam03984 391037006689 Repeat of unknown function (DUF346); Region: DUF346; pfam03984 391037006690 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 391037006691 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 391037006692 Putative esterase; Region: Esterase; pfam00756 391037006693 LGFP repeat; Region: LGFP; pfam08310 391037006694 LGFP repeat; Region: LGFP; pfam08310 391037006695 LGFP repeat; Region: LGFP; pfam08310 391037006696 Putative esterase; Region: Esterase; pfam00756 391037006697 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 391037006698 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037006699 putative metal binding site [ion binding]; other site 391037006700 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391037006701 active site 391037006702 catalytic residues [active] 391037006703 metal binding site [ion binding]; metal-binding site 391037006704 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 391037006705 MarR family; Region: MarR_2; pfam12802 391037006706 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 391037006707 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 391037006708 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391037006709 glycine dehydrogenase; Provisional; Region: PRK05367 391037006710 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037006711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037006712 catalytic residue [active] 391037006713 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391037006714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037006715 tetramer interface [polypeptide binding]; other site 391037006716 catalytic residue [active] 391037006717 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 391037006718 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391037006719 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037006720 DNA binding residues [nucleotide binding] 391037006721 Bifunctional nuclease; Region: DNase-RNase; pfam02577 391037006722 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 391037006723 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037006724 DNA binding residues [nucleotide binding] 391037006725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 391037006726 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 391037006727 phosphopeptide binding site; other site 391037006728 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391037006729 lipoyl attachment site [posttranslational modification]; other site 391037006730 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 391037006731 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 391037006732 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 391037006733 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391037006734 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037006735 Ligand Binding Site [chemical binding]; other site 391037006736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037006737 Ligand Binding Site [chemical binding]; other site 391037006738 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391037006739 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 391037006740 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 391037006741 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037006742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037006743 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037006744 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 391037006745 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 391037006746 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037006747 Cytochrome P450; Region: p450; cl12078 391037006748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037006749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006750 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391037006751 hydrophobic ligand binding site; other site 391037006752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006753 putative substrate translocation pore; other site 391037006754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037006755 NAD(P) binding site [chemical binding]; other site 391037006756 active site 391037006757 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391037006758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 391037006759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037006760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037006761 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 391037006762 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 391037006763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037006764 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 391037006765 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391037006766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006767 Walker A/P-loop; other site 391037006768 ATP binding site [chemical binding]; other site 391037006769 Q-loop/lid; other site 391037006770 ABC transporter signature motif; other site 391037006771 Walker B; other site 391037006772 D-loop; other site 391037006773 H-loop/switch region; other site 391037006774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037006775 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391037006776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037006777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037006778 putative PBP binding loops; other site 391037006779 dimer interface [polypeptide binding]; other site 391037006780 ABC-ATPase subunit interface; other site 391037006781 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 391037006782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391037006783 lycopene cyclase; Region: lycopene_cycl; TIGR01789 391037006784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006785 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391037006786 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391037006787 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391037006788 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391037006789 acyl-activating enzyme (AAE) consensus motif; other site 391037006790 putative AMP binding site [chemical binding]; other site 391037006791 putative active site [active] 391037006792 putative CoA binding site [chemical binding]; other site 391037006793 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 391037006794 Ion channel; Region: Ion_trans_2; pfam07885 391037006795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037006796 MarR family; Region: MarR; pfam01047 391037006797 Predicted membrane protein [Function unknown]; Region: COG2323 391037006798 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006799 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006800 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006801 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006802 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037006803 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037006804 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037006805 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037006806 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 391037006807 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391037006808 metal binding site [ion binding]; metal-binding site 391037006809 putative dimer interface [polypeptide binding]; other site 391037006810 RibD C-terminal domain; Region: RibD_C; cl17279 391037006811 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 391037006812 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391037006813 catalytic motif [active] 391037006814 Zn binding site [ion binding]; other site 391037006815 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 391037006816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037006817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037006818 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 391037006819 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 391037006820 CT1975-like protein; Region: Cas_CT1975; pfam09344 391037006821 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 391037006822 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 391037006823 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 391037006824 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 391037006825 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 391037006826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037006827 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 391037006828 DNA-binding interface [nucleotide binding]; DNA binding site 391037006829 Integrase core domain; Region: rve; pfam00665 391037006830 Integrase core domain; Region: rve_3; cl15866 391037006831 transposase; Provisional; Region: PRK06526 391037006832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006833 Walker A motif; other site 391037006834 ATP binding site [chemical binding]; other site 391037006835 Walker B motif; other site 391037006836 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 391037006837 YcaO-like family; Region: YcaO; pfam02624 391037006838 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 391037006839 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 391037006840 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037006841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037006842 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037006843 Walker A/P-loop; other site 391037006844 ATP binding site [chemical binding]; other site 391037006845 Q-loop/lid; other site 391037006846 ABC transporter signature motif; other site 391037006847 Walker B; other site 391037006848 D-loop; other site 391037006849 H-loop/switch region; other site 391037006850 SpaB C-terminal domain; Region: SpaB_C; pfam14028 391037006851 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037006852 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037006853 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 391037006854 FMN binding site [chemical binding]; other site 391037006855 dimer interface [polypeptide binding]; other site 391037006856 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 391037006857 putative FMN binding site [chemical binding]; other site 391037006858 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 391037006859 YcaO-like family; Region: YcaO; pfam02624 391037006860 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 391037006861 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 391037006862 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 391037006863 YcaO-like family; Region: YcaO; pfam02624 391037006864 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 391037006865 DNA binding site [nucleotide binding] 391037006866 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037006867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037006868 Walker A motif; other site 391037006869 ATP binding site [chemical binding]; other site 391037006870 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 391037006871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037006872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037006873 DNA binding residues [nucleotide binding] 391037006874 dimerization interface [polypeptide binding]; other site 391037006875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 391037006876 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 391037006877 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 391037006878 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 391037006879 FAD binding pocket [chemical binding]; other site 391037006880 FAD binding motif [chemical binding]; other site 391037006881 phosphate binding motif [ion binding]; other site 391037006882 NAD binding pocket [chemical binding]; other site 391037006883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006885 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 391037006886 putative active site [active] 391037006887 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 391037006888 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 391037006889 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 391037006890 Calx-beta domain; Region: Calx-beta; cl02522 391037006891 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391037006892 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 391037006893 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 391037006894 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037006895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037006896 non-specific DNA binding site [nucleotide binding]; other site 391037006897 salt bridge; other site 391037006898 sequence-specific DNA binding site [nucleotide binding]; other site 391037006899 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 391037006900 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 391037006901 putative NADP binding site [chemical binding]; other site 391037006902 putative substrate binding site [chemical binding]; other site 391037006903 active site 391037006904 BNR repeat-like domain; Region: BNR_2; pfam13088 391037006905 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037006906 nudix motif; other site 391037006907 Predicted membrane protein [Function unknown]; Region: COG4270 391037006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037006909 putative substrate translocation pore; other site 391037006910 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037006911 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391037006912 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391037006913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006914 S-adenosylmethionine binding site [chemical binding]; other site 391037006915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037006916 non-specific DNA binding site [nucleotide binding]; other site 391037006917 salt bridge; other site 391037006918 sequence-specific DNA binding site [nucleotide binding]; other site 391037006919 Cupin domain; Region: Cupin_2; pfam07883 391037006920 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391037006921 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391037006922 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 391037006923 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 391037006924 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391037006925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037006926 ABC-ATPase subunit interface; other site 391037006927 dimer interface [polypeptide binding]; other site 391037006928 putative PBP binding regions; other site 391037006929 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391037006930 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 391037006931 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391037006933 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 391037006934 intersubunit interface [polypeptide binding]; other site 391037006935 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006936 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391037006937 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006938 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 391037006939 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006940 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 391037006941 CARDB; Region: CARDB; pfam07705 391037006942 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006943 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006944 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 391037006945 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037006946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037006947 S-adenosylmethionine binding site [chemical binding]; other site 391037006948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391037006949 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 391037006950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037006951 dimer interface [polypeptide binding]; other site 391037006952 conserved gate region; other site 391037006953 putative PBP binding loops; other site 391037006954 ABC-ATPase subunit interface; other site 391037006955 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391037006956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037006957 Walker A/P-loop; other site 391037006958 ATP binding site [chemical binding]; other site 391037006959 Q-loop/lid; other site 391037006960 ABC transporter signature motif; other site 391037006961 Walker B; other site 391037006962 D-loop; other site 391037006963 H-loop/switch region; other site 391037006964 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391037006965 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391037006966 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 391037006967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037006968 motif II; other site 391037006969 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 391037006970 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037006971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037006972 DNA-binding site [nucleotide binding]; DNA binding site 391037006973 UTRA domain; Region: UTRA; pfam07702 391037006974 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 391037006975 Protein of unknown function (DUF817); Region: DUF817; pfam05675 391037006976 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 391037006977 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037006978 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 391037006979 Right handed beta helix region; Region: Beta_helix; pfam13229 391037006980 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391037006981 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 391037006982 ribonuclease E; Reviewed; Region: rne; PRK10811 391037006983 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 391037006984 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 391037006985 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 391037006986 active site 391037006987 pyridoxamine kinase; Validated; Region: PRK05756 391037006988 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 391037006989 dimer interface [polypeptide binding]; other site 391037006990 pyridoxal binding site [chemical binding]; other site 391037006991 ATP binding site [chemical binding]; other site 391037006992 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037006993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391037006994 P-loop; other site 391037006995 Magnesium ion binding site [ion binding]; other site 391037006996 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037006997 Tetratricopeptide repeat; Region: TPR_10; pfam13374 391037006998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037006999 Tetratricopeptide repeat; Region: TPR_10; pfam13374 391037007000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037007001 Tetratricopeptide repeat; Region: TPR_10; pfam13374 391037007002 TIR domain; Region: TIR_2; pfam13676 391037007003 TIR domain; Region: TIR_2; pfam13676 391037007004 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 391037007005 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 391037007006 HEXXH motif domain; Region: mod_HExxH; TIGR04267 391037007007 FXSXX-COOH protein; Region: FxSxx-COOH; TIGR04268 391037007008 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 391037007009 heat shock protein 90; Provisional; Region: PRK05218 391037007010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037007011 ATP binding site [chemical binding]; other site 391037007012 Mg2+ binding site [ion binding]; other site 391037007013 G-X-G motif; other site 391037007014 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391037007015 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391037007016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037007017 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 391037007018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007019 homodimer interface [polypeptide binding]; other site 391037007020 catalytic residue [active] 391037007021 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 391037007022 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391037007023 active site 391037007024 substrate binding site [chemical binding]; other site 391037007025 FMN binding site [chemical binding]; other site 391037007026 putative catalytic residues [active] 391037007027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 391037007028 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391037007029 substrate binding pocket [chemical binding]; other site 391037007030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037007031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037007032 Cytochrome P450; Region: p450; cl12078 391037007033 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 391037007034 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 391037007035 active site 391037007036 catalytic triad [active] 391037007037 oxyanion hole [active] 391037007038 acyl-CoA synthetase; Validated; Region: PRK06188 391037007039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007040 acyl-activating enzyme (AAE) consensus motif; other site 391037007041 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007042 AMP binding site [chemical binding]; other site 391037007043 active site 391037007044 acyl-activating enzyme (AAE) consensus motif; other site 391037007045 CoA binding site [chemical binding]; other site 391037007046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037007047 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037007048 putative substrate translocation pore; other site 391037007049 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 391037007050 active site 391037007051 catalytic triad [active] 391037007052 oxyanion hole [active] 391037007053 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403 391037007054 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391037007055 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391037007056 PYR/PP interface [polypeptide binding]; other site 391037007057 dimer interface [polypeptide binding]; other site 391037007058 TPP binding site [chemical binding]; other site 391037007059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037007060 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391037007061 tetramer interface [polypeptide binding]; other site 391037007062 TPP-binding site [chemical binding]; other site 391037007063 heterodimer interface [polypeptide binding]; other site 391037007064 phosphorylation loop region [posttranslational modification] 391037007065 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 391037007066 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391037007067 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 391037007068 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 391037007069 dimer interface [polypeptide binding]; other site 391037007070 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 391037007071 active site 391037007072 Fe binding site [ion binding]; other site 391037007073 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391037007074 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391037007075 dimer interface [polypeptide binding]; other site 391037007076 active site 391037007077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037007078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007079 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007080 acyl-activating enzyme (AAE) consensus motif; other site 391037007081 acyl-activating enzyme (AAE) consensus motif; other site 391037007082 AMP binding site [chemical binding]; other site 391037007083 active site 391037007084 CoA binding site [chemical binding]; other site 391037007085 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037007086 active site 391037007087 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391037007088 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 391037007089 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037007090 AMP-binding enzyme; Region: AMP-binding; pfam00501 391037007091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007092 acyl-activating enzyme (AAE) consensus motif; other site 391037007093 AMP binding site [chemical binding]; other site 391037007094 active site 391037007095 CoA binding site [chemical binding]; other site 391037007096 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391037007097 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037007098 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391037007099 active site 391037007100 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391037007101 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391037007102 dimer interface [polypeptide binding]; other site 391037007103 active site 391037007104 Cupin domain; Region: Cupin_2; pfam07883 391037007105 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 391037007106 putative hydrophobic ligand binding site [chemical binding]; other site 391037007107 active site 391037007108 catalytic residues_2 [active] 391037007109 catalytic residues_1 [active] 391037007110 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391037007111 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037007112 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037007113 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391037007114 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391037007115 carboxyltransferase (CT) interaction site; other site 391037007116 biotinylation site [posttranslational modification]; other site 391037007117 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391037007118 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391037007119 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 391037007120 Bacterial transcriptional activator domain; Region: BTAD; smart01043 391037007121 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 391037007122 putative monooxygenase; Reviewed; Region: PRK07045 391037007123 hypothetical protein; Provisional; Region: PRK07236 391037007124 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037007125 Y-family of DNA polymerases; Region: PolY; cl12025 391037007126 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391037007127 CoenzymeA binding site [chemical binding]; other site 391037007128 subunit interaction site [polypeptide binding]; other site 391037007129 PHB binding site; other site 391037007130 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 391037007131 CrcB-like protein; Region: CRCB; cl09114 391037007132 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 391037007133 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391037007134 putative active site [active] 391037007135 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 391037007136 putative active site [active] 391037007137 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391037007138 homodimer interface [polypeptide binding]; other site 391037007139 active site 391037007140 SAM binding site [chemical binding]; other site 391037007141 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 391037007142 Precorrin-8X methylmutase; Region: CbiC; pfam02570 391037007143 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 391037007144 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391037007145 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 391037007146 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 391037007147 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 391037007148 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 391037007149 active site 391037007150 SAM binding site [chemical binding]; other site 391037007151 homodimer interface [polypeptide binding]; other site 391037007152 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 391037007153 active site 391037007154 SAM binding site [chemical binding]; other site 391037007155 putative homodimer interface [polypeptide binding]; other site 391037007156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037007157 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 391037007158 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 391037007159 active site 391037007160 SAM binding site [chemical binding]; other site 391037007161 homodimer interface [polypeptide binding]; other site 391037007162 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 391037007163 active site 391037007164 SAM binding site [chemical binding]; other site 391037007165 homodimer interface [polypeptide binding]; other site 391037007166 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 391037007167 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 391037007168 catalytic triad [active] 391037007169 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391037007170 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 391037007171 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 391037007172 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 391037007173 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391037007174 metal ion-dependent adhesion site (MIDAS); other site 391037007175 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 391037007176 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391037007177 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391037007178 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391037007179 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391037007180 FAD binding domain; Region: FAD_binding_2; pfam00890 391037007181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037007182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037007183 DNA binding site [nucleotide binding] 391037007184 domain linker motif; other site 391037007185 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391037007186 ligand binding site [chemical binding]; other site 391037007187 dimerization interface [polypeptide binding]; other site 391037007188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037007189 putative substrate translocation pore; other site 391037007190 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 391037007191 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 391037007192 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037007193 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037007194 Walker A/P-loop; other site 391037007195 ATP binding site [chemical binding]; other site 391037007196 Q-loop/lid; other site 391037007197 ABC transporter signature motif; other site 391037007198 Walker B; other site 391037007199 D-loop; other site 391037007200 H-loop/switch region; other site 391037007201 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 391037007202 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391037007203 S-formylglutathione hydrolase; Region: PLN02442 391037007204 Putative esterase; Region: Esterase; pfam00756 391037007205 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037007206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037007207 putative substrate translocation pore; other site 391037007208 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 391037007209 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 391037007210 active site 391037007211 dimer interface [polypeptide binding]; other site 391037007212 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 391037007213 Ligand Binding Site [chemical binding]; other site 391037007214 Molecular Tunnel; other site 391037007215 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 391037007216 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 391037007217 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391037007218 metal binding site 2 [ion binding]; metal-binding site 391037007219 putative DNA binding helix; other site 391037007220 metal binding site 1 [ion binding]; metal-binding site 391037007221 dimer interface [polypeptide binding]; other site 391037007222 structural Zn2+ binding site [ion binding]; other site 391037007223 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 391037007224 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037007225 DNA binding residues [nucleotide binding] 391037007226 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 391037007227 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 391037007228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391037007229 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391037007230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037007231 putative PBP binding loops; other site 391037007232 ABC-ATPase subunit interface; other site 391037007233 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 391037007234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037007235 Walker A/P-loop; other site 391037007236 ATP binding site [chemical binding]; other site 391037007237 Q-loop/lid; other site 391037007238 ABC transporter signature motif; other site 391037007239 Walker B; other site 391037007240 D-loop; other site 391037007241 H-loop/switch region; other site 391037007242 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391037007243 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037007244 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037007245 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 391037007246 IucA / IucC family; Region: IucA_IucC; pfam04183 391037007247 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 391037007248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 391037007249 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 391037007250 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 391037007251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037007252 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 391037007253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007254 catalytic residue [active] 391037007255 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 391037007256 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391037007257 intersubunit interface [polypeptide binding]; other site 391037007258 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 391037007259 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391037007260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037007261 ABC-ATPase subunit interface; other site 391037007262 dimer interface [polypeptide binding]; other site 391037007263 putative PBP binding regions; other site 391037007264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037007265 ABC-ATPase subunit interface; other site 391037007266 dimer interface [polypeptide binding]; other site 391037007267 putative PBP binding regions; other site 391037007268 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391037007269 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391037007270 Walker A/P-loop; other site 391037007271 ATP binding site [chemical binding]; other site 391037007272 Q-loop/lid; other site 391037007273 ABC transporter signature motif; other site 391037007274 Walker B; other site 391037007275 D-loop; other site 391037007276 H-loop/switch region; other site 391037007277 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391037007278 active site 391037007279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 391037007280 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 391037007281 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391037007282 dimerization interface [polypeptide binding]; other site 391037007283 active site 391037007284 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037007285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037007286 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 391037007287 active site 391037007288 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037007289 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037007290 NAD(P) binding site [chemical binding]; other site 391037007291 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 391037007292 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 391037007293 Ligand binding site; other site 391037007294 Putative Catalytic site; other site 391037007295 DXD motif; other site 391037007296 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 391037007297 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391037007298 transcriptional regulator BetI; Validated; Region: PRK00767 391037007299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037007300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037007301 NAD(P) binding site [chemical binding]; other site 391037007302 active site 391037007303 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391037007304 Moco binding site; other site 391037007305 metal coordination site [ion binding]; other site 391037007306 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 391037007307 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 391037007308 FAD binding pocket [chemical binding]; other site 391037007309 FAD binding motif [chemical binding]; other site 391037007310 phosphate binding motif [ion binding]; other site 391037007311 NAD binding pocket [chemical binding]; other site 391037007312 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 391037007313 Sporulation and spore germination; Region: Germane; pfam10646 391037007314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037007315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037007316 dimerization interface [polypeptide binding]; other site 391037007317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037007318 dimer interface [polypeptide binding]; other site 391037007319 phosphorylation site [posttranslational modification] 391037007320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037007321 ATP binding site [chemical binding]; other site 391037007322 Mg2+ binding site [ion binding]; other site 391037007323 G-X-G motif; other site 391037007324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037007325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037007326 active site 391037007327 phosphorylation site [posttranslational modification] 391037007328 intermolecular recognition site; other site 391037007329 dimerization interface [polypeptide binding]; other site 391037007330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037007331 DNA binding site [nucleotide binding] 391037007332 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037007333 anti sigma factor interaction site; other site 391037007334 regulatory phosphorylation site [posttranslational modification]; other site 391037007335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037007336 anti sigma factor interaction site; other site 391037007337 regulatory phosphorylation site [posttranslational modification]; other site 391037007338 BON domain; Region: BON; pfam04972 391037007339 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391037007340 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037007341 FAD binding domain; Region: FAD_binding_4; pfam01565 391037007342 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 391037007343 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 391037007344 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 391037007345 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 391037007346 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 391037007347 Ligand binding site; other site 391037007348 Putative Catalytic site; other site 391037007349 DXD motif; other site 391037007350 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 391037007351 Sodium Bile acid symporter family; Region: SBF; cl17470 391037007352 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 391037007353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037007354 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037007355 Walker A/P-loop; other site 391037007356 ATP binding site [chemical binding]; other site 391037007357 Q-loop/lid; other site 391037007358 ABC transporter signature motif; other site 391037007359 Walker B; other site 391037007360 D-loop; other site 391037007361 H-loop/switch region; other site 391037007362 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 391037007363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037007364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007365 homodimer interface [polypeptide binding]; other site 391037007366 catalytic residue [active] 391037007367 RNA polymerase sigma factor; Provisional; Region: PRK12535 391037007368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037007369 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037007370 DNA binding residues [nucleotide binding] 391037007371 Putative zinc-finger; Region: zf-HC2; pfam13490 391037007372 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391037007373 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 391037007374 CopC domain; Region: CopC; pfam04234 391037007375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391037007376 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 391037007377 Walker A/P-loop; other site 391037007378 ATP binding site [chemical binding]; other site 391037007379 Q-loop/lid; other site 391037007380 ABC transporter signature motif; other site 391037007381 Walker B; other site 391037007382 D-loop; other site 391037007383 H-loop/switch region; other site 391037007384 Cobalt transport protein; Region: CbiQ; cl00463 391037007385 cobalt transport protein CbiN; Provisional; Region: PRK02898 391037007386 cobalt transport protein CbiM; Validated; Region: PRK08319 391037007387 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 391037007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037007389 S-adenosylmethionine binding site [chemical binding]; other site 391037007390 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 391037007391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037007392 FeS/SAM binding site; other site 391037007393 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037007394 Transcriptional regulator PadR-like family; Region: PadR; cl17335 391037007395 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 391037007396 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037007397 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 391037007398 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 391037007399 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391037007400 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 391037007401 NAD binding site [chemical binding]; other site 391037007402 catalytic Zn binding site [ion binding]; other site 391037007403 substrate binding site [chemical binding]; other site 391037007404 structural Zn binding site [ion binding]; other site 391037007405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037007406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037007407 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 391037007408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037007409 NAD(P) binding site [chemical binding]; other site 391037007410 active site 391037007411 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391037007412 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391037007413 NAD(P) binding site [chemical binding]; other site 391037007414 catalytic residues [active] 391037007415 enoyl-CoA hydratase; Provisional; Region: PRK06495 391037007416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037007417 substrate binding site [chemical binding]; other site 391037007418 oxyanion hole (OAH) forming residues; other site 391037007419 trimer interface [polypeptide binding]; other site 391037007420 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 391037007421 Coenzyme A transferase; Region: CoA_trans; cl17247 391037007422 Nitronate monooxygenase; Region: NMO; pfam03060 391037007423 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 391037007424 FMN binding site [chemical binding]; other site 391037007425 substrate binding site [chemical binding]; other site 391037007426 putative catalytic residue [active] 391037007427 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 391037007428 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037007429 dimer interface [polypeptide binding]; other site 391037007430 active site 391037007431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007432 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 391037007433 FAD binding site [chemical binding]; other site 391037007434 substrate binding site [chemical binding]; other site 391037007435 catalytic base [active] 391037007436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007438 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391037007439 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391037007440 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037007441 Cytochrome P450; Region: p450; cl12078 391037007442 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 391037007443 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037007444 dimer interface [polypeptide binding]; other site 391037007445 active site 391037007446 short chain dehydrogenase; Provisional; Region: PRK07831 391037007447 classical (c) SDRs; Region: SDR_c; cd05233 391037007448 NAD(P) binding site [chemical binding]; other site 391037007449 active site 391037007450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007451 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391037007452 active site 391037007453 enoyl-CoA hydratase; Provisional; Region: PRK08290 391037007454 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037007455 substrate binding site [chemical binding]; other site 391037007456 oxyanion hole (OAH) forming residues; other site 391037007457 trimer interface [polypeptide binding]; other site 391037007458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007460 active site 391037007461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007462 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037007463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007464 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 391037007465 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037007466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007467 active site 391037007468 lipid-transfer protein; Provisional; Region: PRK07855 391037007469 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 391037007470 active site 391037007471 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037007472 active site 2 [active] 391037007473 active site 1 [active] 391037007474 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037007475 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391037007476 DUF35 OB-fold domain; Region: DUF35; pfam01796 391037007477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007478 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037007479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007480 active site 391037007481 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007483 active site 391037007484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037007485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037007486 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391037007487 CoenzymeA binding site [chemical binding]; other site 391037007488 subunit interaction site [polypeptide binding]; other site 391037007489 PHB binding site; other site 391037007490 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 391037007491 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391037007492 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037007493 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 391037007494 putative NAD(P) binding site [chemical binding]; other site 391037007495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037007496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391037007497 NAD(P) binding site [chemical binding]; other site 391037007498 active site 391037007499 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391037007500 short chain dehydrogenase; Provisional; Region: PRK07856 391037007501 classical (c) SDRs; Region: SDR_c; cd05233 391037007502 NAD(P) binding site [chemical binding]; other site 391037007503 active site 391037007504 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 391037007505 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037007506 short chain dehydrogenase; Provisional; Region: PRK07890 391037007507 classical (c) SDRs; Region: SDR_c; cd05233 391037007508 NAD(P) binding site [chemical binding]; other site 391037007509 active site 391037007510 Nitronate monooxygenase; Region: NMO; pfam03060 391037007511 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 391037007512 FMN binding site [chemical binding]; other site 391037007513 substrate binding site [chemical binding]; other site 391037007514 putative catalytic residue [active] 391037007515 acyl-CoA synthetase; Validated; Region: PRK07798 391037007516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007517 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 391037007518 acyl-activating enzyme (AAE) consensus motif; other site 391037007519 acyl-activating enzyme (AAE) consensus motif; other site 391037007520 putative AMP binding site [chemical binding]; other site 391037007521 putative active site [active] 391037007522 putative CoA binding site [chemical binding]; other site 391037007523 enoyl-CoA hydratase; Provisional; Region: PRK07799 391037007524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037007525 substrate binding site [chemical binding]; other site 391037007526 oxyanion hole (OAH) forming residues; other site 391037007527 trimer interface [polypeptide binding]; other site 391037007528 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 391037007529 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 391037007530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007531 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 391037007532 acyl-activating enzyme (AAE) consensus motif; other site 391037007533 putative AMP binding site [chemical binding]; other site 391037007534 putative active site [active] 391037007535 acyl-activating enzyme (AAE) consensus motif; other site 391037007536 putative CoA binding site [chemical binding]; other site 391037007537 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 391037007538 DUF35 OB-fold domain; Region: DUF35; pfam01796 391037007539 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 391037007540 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391037007541 DUF35 OB-fold domain; Region: DUF35; pfam01796 391037007542 lipid-transfer protein; Provisional; Region: PRK07937 391037007543 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 391037007544 active site 391037007545 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 391037007546 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 391037007547 active site 391037007548 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 391037007549 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 391037007550 calcium binding site 2 [ion binding]; other site 391037007551 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 391037007552 active site 391037007553 catalytic triad [active] 391037007554 calcium binding site 1 [ion binding]; other site 391037007555 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 391037007556 oligomer interface [polypeptide binding]; other site 391037007557 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 391037007558 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 391037007559 Flavoprotein; Region: Flavoprotein; pfam02441 391037007560 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391037007561 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 391037007562 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391037007563 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391037007564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037007565 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037007566 DNA-binding interface [nucleotide binding]; DNA binding site 391037007567 Integrase core domain; Region: rve; pfam00665 391037007568 Integrase core domain; Region: rve_3; cl15866 391037007569 transposase; Provisional; Region: PRK06526 391037007570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037007571 Walker A motif; other site 391037007572 ATP binding site [chemical binding]; other site 391037007573 Walker B motif; other site 391037007574 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 391037007575 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037007576 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 391037007577 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 391037007578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037007579 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 391037007580 acyl-activating enzyme (AAE) consensus motif; other site 391037007581 acyl-activating enzyme (AAE) consensus motif; other site 391037007582 putative AMP binding site [chemical binding]; other site 391037007583 putative active site [active] 391037007584 putative CoA binding site [chemical binding]; other site 391037007585 CoA binding site [chemical binding]; other site 391037007586 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 391037007587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037007588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391037007589 dimerization interface [polypeptide binding]; other site 391037007590 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 391037007591 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 391037007592 Caspase domain; Region: Peptidase_C14; pfam00656 391037007593 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 391037007594 AAA domain; Region: AAA_12; pfam13087 391037007595 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 391037007596 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 391037007597 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391037007598 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 391037007599 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 391037007600 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 391037007601 active site 391037007602 Fe binding site [ion binding]; other site 391037007603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037007604 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391037007605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007606 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 391037007607 Flavin binding site [chemical binding]; other site 391037007608 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391037007609 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 391037007610 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 391037007611 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 391037007612 FAD binding pocket [chemical binding]; other site 391037007613 FAD binding motif [chemical binding]; other site 391037007614 phosphate binding motif [ion binding]; other site 391037007615 beta-alpha-beta structure motif; other site 391037007616 NAD(p) ribose binding residues [chemical binding]; other site 391037007617 NAD binding pocket [chemical binding]; other site 391037007618 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 391037007619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037007620 catalytic loop [active] 391037007621 iron binding site [ion binding]; other site 391037007622 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 391037007623 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391037007624 FAD binding domain; Region: FAD_binding_2; pfam00890 391037007625 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391037007626 enoyl-CoA hydratase; Region: PLN02864 391037007627 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037007628 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 391037007629 dimer interaction site [polypeptide binding]; other site 391037007630 substrate-binding tunnel; other site 391037007631 active site 391037007632 catalytic site [active] 391037007633 substrate binding site [chemical binding]; other site 391037007634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007636 active site 391037007637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037007638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037007639 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391037007640 hydrophobic ligand binding site; other site 391037007641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037007642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037007643 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391037007644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391037007645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037007646 active site residue [active] 391037007647 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037007648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037007649 DNA-binding site [nucleotide binding]; DNA binding site 391037007650 UTRA domain; Region: UTRA; pfam07702 391037007651 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037007652 active site residue [active] 391037007653 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391037007654 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 391037007655 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 391037007656 active site 391037007657 Ca binding site [ion binding]; other site 391037007658 catalytic site [active] 391037007659 Aamy_C domain; Region: Aamy_C; smart00632 391037007660 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 391037007661 starch-binding site 2 [chemical binding]; other site 391037007662 starch-binding site 1 [chemical binding]; other site 391037007663 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 391037007664 starch-binding site 2 [chemical binding]; other site 391037007665 starch-binding site 1 [chemical binding]; other site 391037007666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037007667 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 391037007668 dimer interface [polypeptide binding]; other site 391037007669 ligand binding site [chemical binding]; other site 391037007670 Helix-turn-helix domain; Region: HTH_18; pfam12833 391037007671 Protein of unknown function (DUF664); Region: DUF664; pfam04978 391037007672 DinB superfamily; Region: DinB_2; pfam12867 391037007673 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 391037007674 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 391037007675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391037007676 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 391037007677 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391037007678 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 391037007679 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 391037007680 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391037007681 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391037007682 NADP binding site [chemical binding]; other site 391037007683 active site 391037007684 steroid binding site; other site 391037007685 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 391037007686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037007687 FeS/SAM binding site; other site 391037007688 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 391037007689 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 391037007690 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 391037007691 putative ADP-ribose binding site [chemical binding]; other site 391037007692 putative active site [active] 391037007693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037007694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037007695 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 391037007696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037007697 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 391037007698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037007699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037007700 active site 391037007701 phosphorylation site [posttranslational modification] 391037007702 intermolecular recognition site; other site 391037007703 dimerization interface [polypeptide binding]; other site 391037007704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037007705 DNA binding site [nucleotide binding] 391037007706 HAMP domain; Region: HAMP; pfam00672 391037007707 dimerization interface [polypeptide binding]; other site 391037007708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037007709 dimer interface [polypeptide binding]; other site 391037007710 phosphorylation site [posttranslational modification] 391037007711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037007712 ATP binding site [chemical binding]; other site 391037007713 Mg2+ binding site [ion binding]; other site 391037007714 G-X-G motif; other site 391037007715 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391037007716 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 391037007717 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391037007718 YCII-related domain; Region: YCII; cl00999 391037007719 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391037007720 putative active site [active] 391037007721 putative catalytic site [active] 391037007722 hypothetical protein; Provisional; Region: PRK07505 391037007723 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 391037007724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037007725 catalytic residue [active] 391037007726 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391037007727 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037007728 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037007729 NAD(P) binding site [chemical binding]; other site 391037007730 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037007731 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391037007732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037007733 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391037007734 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 391037007735 Walker A motif; other site 391037007736 ATP binding site [chemical binding]; other site 391037007737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391037007738 metal ion-dependent adhesion site (MIDAS); other site 391037007739 AAA ATPase domain; Region: AAA_16; pfam13191 391037007740 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391037007741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037007742 S-adenosylmethionine binding site [chemical binding]; other site 391037007743 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391037007744 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391037007745 homodimer interface [polypeptide binding]; other site 391037007746 active site 391037007747 TDP-binding site; other site 391037007748 acceptor substrate-binding pocket; other site 391037007749 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 391037007750 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 391037007751 putative heme binding site [chemical binding]; other site 391037007752 putative substrate binding site [chemical binding]; other site 391037007753 RNA polymerase factor sigma-70; Validated; Region: PRK08241 391037007754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037007755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037007756 DNA binding residues [nucleotide binding] 391037007757 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037007758 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037007759 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037007760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037007761 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 391037007762 Walker A/P-loop; other site 391037007763 ATP binding site [chemical binding]; other site 391037007764 Q-loop/lid; other site 391037007765 ABC transporter signature motif; other site 391037007766 Walker B; other site 391037007767 D-loop; other site 391037007768 H-loop/switch region; other site 391037007769 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391037007770 B12 binding site [chemical binding]; other site 391037007771 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 391037007772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037007773 FeS/SAM binding site; other site 391037007774 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391037007775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037007776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037007777 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391037007778 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391037007779 inhibitor-cofactor binding pocket; inhibition site 391037007780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007781 catalytic residue [active] 391037007782 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 391037007783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037007784 Coenzyme A binding pocket [chemical binding]; other site 391037007785 Condensation domain; Region: Condensation; pfam00668 391037007786 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037007787 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 391037007788 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037007789 acyl-activating enzyme (AAE) consensus motif; other site 391037007790 AMP binding site [chemical binding]; other site 391037007791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037007792 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037007793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037007794 catalytic residue [active] 391037007795 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391037007796 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391037007797 putative di-iron ligands [ion binding]; other site 391037007798 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391037007799 B12 binding site [chemical binding]; other site 391037007800 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 391037007801 substrate binding site [chemical binding]; other site 391037007802 B12 cofactor binding site [chemical binding]; other site 391037007803 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 391037007804 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 391037007805 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391037007806 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391037007807 thiamine pyrophosphate protein; Validated; Region: PRK08199 391037007808 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391037007809 PYR/PP interface [polypeptide binding]; other site 391037007810 dimer interface [polypeptide binding]; other site 391037007811 TPP binding site [chemical binding]; other site 391037007812 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037007813 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391037007814 TPP-binding site [chemical binding]; other site 391037007815 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 391037007816 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391037007817 dimer interface [polypeptide binding]; other site 391037007818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007819 catalytic residue [active] 391037007820 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391037007821 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391037007822 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 391037007823 NAD(P) binding pocket [chemical binding]; other site 391037007824 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 391037007825 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 391037007826 tetramer interface [polypeptide binding]; other site 391037007827 active site 391037007828 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391037007829 classical (c) SDRs; Region: SDR_c; cd05233 391037007830 NAD(P) binding site [chemical binding]; other site 391037007831 active site 391037007832 hypothetical protein; Provisional; Region: PRK06062 391037007833 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037007834 inhibitor-cofactor binding pocket; inhibition site 391037007835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037007836 catalytic residue [active] 391037007837 Condensation domain; Region: Condensation; pfam00668 391037007838 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037007839 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037007840 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037007841 acyl-activating enzyme (AAE) consensus motif; other site 391037007842 AMP binding site [chemical binding]; other site 391037007843 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037007844 Condensation domain; Region: Condensation; pfam00668 391037007845 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037007846 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037007847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037007848 acyl-activating enzyme (AAE) consensus motif; other site 391037007849 AMP binding site [chemical binding]; other site 391037007850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037007851 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 391037007852 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037007853 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037007854 acyl-activating enzyme (AAE) consensus motif; other site 391037007855 AMP binding site [chemical binding]; other site 391037007856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037007858 putative substrate translocation pore; other site 391037007859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037007860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037007861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037007862 non-specific DNA binding site [nucleotide binding]; other site 391037007863 sequence-specific DNA binding site [nucleotide binding]; other site 391037007864 salt bridge; other site 391037007865 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037007866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037007867 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037007868 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 391037007869 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007870 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007871 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037007872 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037007873 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007874 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007875 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007876 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037007877 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007878 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037007879 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007880 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007881 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037007882 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037007883 DNA-binding interface [nucleotide binding]; DNA binding site 391037007884 uridine kinase; Validated; Region: PRK06696 391037007885 active site 391037007886 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391037007887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391037007888 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391037007889 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037007890 putative catalytic site [active] 391037007891 putative metal binding site [ion binding]; other site 391037007892 putative phosphate binding site [ion binding]; other site 391037007893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037007894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037007895 Walker A/P-loop; other site 391037007896 ATP binding site [chemical binding]; other site 391037007897 ABC transporter signature motif; other site 391037007898 Walker B; other site 391037007899 D-loop; other site 391037007900 H-loop/switch region; other site 391037007901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391037007902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037007903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037007904 S-adenosylmethionine binding site [chemical binding]; other site 391037007905 Phosphotransferase enzyme family; Region: APH; pfam01636 391037007906 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391037007907 active site 391037007908 ATP binding site [chemical binding]; other site 391037007909 substrate binding site [chemical binding]; other site 391037007910 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391037007911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037007912 DNA-binding site [nucleotide binding]; DNA binding site 391037007913 FCD domain; Region: FCD; pfam07729 391037007914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037007915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391037007916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037007917 dimer interface [polypeptide binding]; other site 391037007918 conserved gate region; other site 391037007919 putative PBP binding loops; other site 391037007920 ABC-ATPase subunit interface; other site 391037007921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037007922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037007923 dimer interface [polypeptide binding]; other site 391037007924 conserved gate region; other site 391037007925 putative PBP binding loops; other site 391037007926 ABC-ATPase subunit interface; other site 391037007927 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391037007928 classical (c) SDRs; Region: SDR_c; cd05233 391037007929 NAD(P) binding site [chemical binding]; other site 391037007930 active site 391037007931 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391037007932 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 391037007933 metal binding site [ion binding]; metal-binding site 391037007934 substrate binding pocket [chemical binding]; other site 391037007935 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 391037007936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037007937 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391037007938 active site 391037007939 intersubunit interface [polypeptide binding]; other site 391037007940 catalytic residue [active] 391037007941 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391037007942 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391037007943 substrate binding site [chemical binding]; other site 391037007944 ATP binding site [chemical binding]; other site 391037007945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037007946 Cytochrome P450; Region: p450; cl12078 391037007947 phosphoenolpyruvate synthase; Validated; Region: PRK06241 391037007948 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391037007949 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391037007950 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 391037007951 AMP-binding enzyme; Region: AMP-binding; pfam00501 391037007952 acyl-activating enzyme (AAE) consensus motif; other site 391037007953 active site 391037007954 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391037007955 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 391037007956 putative NAD(P) binding site [chemical binding]; other site 391037007957 active site 391037007958 putative substrate binding site [chemical binding]; other site 391037007959 Nucleoside diphosphate kinase; Region: NDK; pfam00334 391037007960 active site 391037007961 prenyltransferase; Provisional; Region: ubiA; PRK13592 391037007962 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 391037007963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037007964 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 391037007965 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 391037007966 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 391037007967 DDE superfamily endonuclease; Region: DDE_4; cl17710 391037007968 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 391037007969 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 391037007970 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391037007971 Uncharacterized conserved protein [Function unknown]; Region: COG1479 391037007972 Protein of unknown function DUF262; Region: DUF262; pfam03235 391037007973 Uncharacterized protein conserved in archaea (DUF2098); Region: DUF2098; cl01640 391037007974 Uncharacterized conserved protein [Function unknown]; Region: COG3472 391037007975 Divergent AAA domain; Region: AAA_4; pfam04326 391037007976 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037007977 hypothetical protein; Provisional; Region: PRK06185 391037007978 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037007979 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037007980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037007981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037007982 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 391037007983 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 391037007984 cleavage site 391037007985 active site 391037007986 substrate binding sites [chemical binding]; other site 391037007987 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 391037007988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037007989 DDE superfamily endonuclease; Region: DDE_4; pfam13359 391037007990 adhesin; Provisional; Region: PRK09752 391037007991 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 391037007992 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037007993 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 391037007994 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391037007995 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 391037007996 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037007997 acyl-activating enzyme (AAE) consensus motif; other site 391037007998 AMP binding site [chemical binding]; other site 391037007999 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391037008000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037008001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037008002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037008003 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037008004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037008005 active site 391037008006 acyl carrier protein; Provisional; Region: PRK07081 391037008007 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 391037008008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 391037008009 dimer interface [polypeptide binding]; other site 391037008010 active site 391037008011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037008012 catalytic residues [active] 391037008013 substrate binding site [chemical binding]; other site 391037008014 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037008015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037008016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037008017 acyl-activating enzyme (AAE) consensus motif; other site 391037008018 acyl-activating enzyme (AAE) consensus motif; other site 391037008019 AMP binding site [chemical binding]; other site 391037008020 active site 391037008021 CoA binding site [chemical binding]; other site 391037008022 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 391037008023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037008024 catalytic residue [active] 391037008025 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391037008026 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 391037008027 BNR repeat-like domain; Region: BNR_2; pfam13088 391037008028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037008029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037008030 active site 391037008031 phosphorylation site [posttranslational modification] 391037008032 intermolecular recognition site; other site 391037008033 dimerization interface [polypeptide binding]; other site 391037008034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037008035 DNA binding site [nucleotide binding] 391037008036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037008037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037008038 dimerization interface [polypeptide binding]; other site 391037008039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037008040 dimer interface [polypeptide binding]; other site 391037008041 phosphorylation site [posttranslational modification] 391037008042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037008043 ATP binding site [chemical binding]; other site 391037008044 Mg2+ binding site [ion binding]; other site 391037008045 G-X-G motif; other site 391037008046 Phosphotransferase enzyme family; Region: APH; pfam01636 391037008047 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 391037008048 Uncharacterized conserved protein [Function unknown]; Region: COG1479 391037008049 Protein of unknown function DUF262; Region: DUF262; pfam03235 391037008050 Uncharacterized conserved protein [Function unknown]; Region: COG3472 391037008051 Divergent AAA domain; Region: AAA_4; pfam04326 391037008052 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 391037008053 Part of AAA domain; Region: AAA_19; pfam13245 391037008054 Family description; Region: UvrD_C_2; pfam13538 391037008055 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 391037008056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037008057 ATP binding site [chemical binding]; other site 391037008058 putative Mg++ binding site [ion binding]; other site 391037008059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037008060 ATP-binding site [chemical binding]; other site 391037008061 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 391037008062 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391037008063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037008064 ATP binding site [chemical binding]; other site 391037008065 putative Mg++ binding site [ion binding]; other site 391037008066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037008067 nucleotide binding region [chemical binding]; other site 391037008068 ATP-binding site [chemical binding]; other site 391037008069 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 391037008070 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 391037008071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037008072 substrate binding site [chemical binding]; other site 391037008073 activation loop (A-loop); other site 391037008074 Part of AAA domain; Region: AAA_19; pfam13245 391037008075 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 391037008076 AAA domain; Region: AAA_12; pfam13087 391037008077 Recombinase; Region: Recombinase; pfam07508 391037008078 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391037008079 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 391037008080 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037008081 AAA ATPase domain; Region: AAA_16; pfam13191 391037008082 NACHT domain; Region: NACHT; pfam05729 391037008083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037008084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391037008085 FliW protein; Region: FliW; cl00740 391037008086 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 391037008087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037008088 DDE superfamily endonuclease; Region: DDE_4; pfam13359 391037008089 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 391037008090 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037008091 Homeodomain-like domain; Region: HTH_23; pfam13384 391037008092 Winged helix-turn helix; Region: HTH_29; pfam13551 391037008093 Homeodomain-like domain; Region: HTH_32; pfam13565 391037008094 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037008095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037008096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037008097 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037008098 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037008099 Interdomain contacts; other site 391037008100 Cytokine receptor motif; other site 391037008101 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037008102 Interdomain contacts; other site 391037008103 Cytokine receptor motif; other site 391037008104 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 391037008105 Interdomain contacts; other site 391037008106 Cytokine receptor motif; other site 391037008107 MoxR-like ATPases [General function prediction only]; Region: COG0714 391037008108 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 391037008109 Walker A motif; other site 391037008110 ATP binding site [chemical binding]; other site 391037008111 Walker B motif; other site 391037008112 arginine finger; other site 391037008113 Protein of unknown function DUF58; Region: DUF58; pfam01882 391037008114 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391037008115 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391037008116 classical (c) SDRs; Region: SDR_c; cd05233 391037008117 NAD(P) binding site [chemical binding]; other site 391037008118 active site 391037008119 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 391037008120 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 391037008121 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 391037008122 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 391037008123 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 391037008124 MMPL family; Region: MMPL; pfam03176 391037008125 MMPL family; Region: MMPL; pfam03176 391037008126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008127 LysE type translocator; Region: LysE; cl00565 391037008128 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 391037008129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037008130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391037008131 dimerization interface [polypeptide binding]; other site 391037008132 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 391037008133 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 391037008134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037008135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037008136 DNA binding residues [nucleotide binding] 391037008137 Lsr2; Region: Lsr2; pfam11774 391037008138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008139 putative substrate translocation pore; other site 391037008140 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037008141 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391037008142 Protein of unknown function (DUF328); Region: DUF328; pfam03883 391037008143 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391037008144 Sulfatase; Region: Sulfatase; pfam00884 391037008145 Sulfatase; Region: Sulfatase; cl17466 391037008146 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 391037008147 Predicted membrane protein [Function unknown]; Region: COG4325 391037008148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037008149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037008150 Coenzyme A binding pocket [chemical binding]; other site 391037008151 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391037008152 Uncharacterized conserved protein [Function unknown]; Region: COG1262 391037008153 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 391037008154 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 391037008155 [4Fe-4S] binding site [ion binding]; other site 391037008156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037008157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037008158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037008159 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 391037008160 molybdopterin cofactor binding site; other site 391037008161 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 391037008162 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 391037008163 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 391037008164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008165 putative substrate translocation pore; other site 391037008166 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 391037008167 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 391037008168 heme-binding site [chemical binding]; other site 391037008169 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 391037008170 FAD binding pocket [chemical binding]; other site 391037008171 FAD binding motif [chemical binding]; other site 391037008172 phosphate binding motif [ion binding]; other site 391037008173 beta-alpha-beta structure motif; other site 391037008174 NAD binding pocket [chemical binding]; other site 391037008175 Heme binding pocket [chemical binding]; other site 391037008176 YwiC-like protein; Region: YwiC; pfam14256 391037008177 Predicted transcriptional regulator [Transcription]; Region: COG2345 391037008178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037008179 putative DNA binding site [nucleotide binding]; other site 391037008180 dimerization interface [polypeptide binding]; other site 391037008181 putative Zn2+ binding site [ion binding]; other site 391037008182 acyl-CoA synthetase; Validated; Region: PRK07787 391037008183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037008184 acyl-activating enzyme (AAE) consensus motif; other site 391037008185 AMP binding site [chemical binding]; other site 391037008186 active site 391037008187 CoA binding site [chemical binding]; other site 391037008188 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391037008189 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 391037008190 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 391037008191 putative sugar binding sites [chemical binding]; other site 391037008192 Q-X-W motif; other site 391037008193 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391037008194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037008195 acyl-activating enzyme (AAE) consensus motif; other site 391037008196 AMP binding site [chemical binding]; other site 391037008197 active site 391037008198 CoA binding site [chemical binding]; other site 391037008199 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 391037008200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008201 NAD(P) binding site [chemical binding]; other site 391037008202 active site 391037008203 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037008204 Cytochrome P450; Region: p450; cl12078 391037008205 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008207 active site 391037008208 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008209 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008210 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008211 Enoylreductase; Region: PKS_ER; smart00829 391037008212 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 391037008213 NAD(P) binding site [chemical binding]; other site 391037008214 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008215 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008216 putative NADP binding site [chemical binding]; other site 391037008217 active site 391037008218 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008219 Thioesterase; Region: PKS_TE; smart00824 391037008220 Erythronolide synthase docking; Region: Docking; pfam08990 391037008221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008222 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037008223 active site 391037008224 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037008225 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008226 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 391037008227 NADP binding site [chemical binding]; other site 391037008228 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008229 active site 391037008230 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008231 Erythronolide synthase docking; Region: Docking; pfam08990 391037008232 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008233 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008234 active site 391037008235 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008236 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008239 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008240 active site 391037008241 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008242 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008243 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008244 active site 391037008245 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008246 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008247 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008248 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008249 putative NADP binding site [chemical binding]; other site 391037008250 active site 391037008251 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008252 Erythronolide synthase docking; Region: Docking; pfam08990 391037008253 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008255 active site 391037008256 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008257 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008259 Enoylreductase; Region: PKS_ER; smart00829 391037008260 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 391037008261 NAD(P) binding site [chemical binding]; other site 391037008262 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008263 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008264 putative NADP binding site [chemical binding]; other site 391037008265 active site 391037008266 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008267 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037008268 Cytochrome P450; Region: p450; cl12078 391037008269 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008270 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037008271 active site 391037008272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037008273 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008274 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008276 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037008277 active site 391037008278 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037008279 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008280 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008281 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008282 putative NADP binding site [chemical binding]; other site 391037008283 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008284 active site 391037008285 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008286 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008287 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008288 active site 391037008289 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008290 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037008291 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 391037008292 putative NADP binding site [chemical binding]; other site 391037008293 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008294 active site 391037008295 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008297 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037008298 active site 391037008299 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037008300 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008301 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 391037008302 NADP binding site [chemical binding]; other site 391037008303 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008304 active site 391037008305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008306 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037008307 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008308 active site 391037008309 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008310 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 391037008311 NADP binding site [chemical binding]; other site 391037008312 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037008313 active site 391037008314 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037008316 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391037008317 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037008318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037008319 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037008320 AAA ATPase domain; Region: AAA_16; pfam13191 391037008321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037008322 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037008323 DNA-binding interface [nucleotide binding]; DNA binding site 391037008324 Integrase core domain; Region: rve; pfam00665 391037008325 Integrase core domain; Region: rve_3; cl15866 391037008326 transposase; Provisional; Region: PRK06526 391037008327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037008328 Walker A motif; other site 391037008329 ATP binding site [chemical binding]; other site 391037008330 Walker B motif; other site 391037008331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037008332 Cytochrome P450; Region: p450; cl12078 391037008333 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 391037008334 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 391037008335 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037008336 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037008337 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037008338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037008339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037008340 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391037008341 putative hydrophobic ligand binding site [chemical binding]; other site 391037008342 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391037008343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037008344 Walker A/P-loop; other site 391037008345 ATP binding site [chemical binding]; other site 391037008346 Q-loop/lid; other site 391037008347 ABC transporter signature motif; other site 391037008348 Walker B; other site 391037008349 D-loop; other site 391037008350 H-loop/switch region; other site 391037008351 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037008352 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037008353 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037008354 active site 391037008355 metal binding site [ion binding]; metal-binding site 391037008356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037008357 active site 391037008358 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037008359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037008360 MarR family; Region: MarR_2; pfam12802 391037008361 AAA domain; Region: AAA_28; pfam13521 391037008362 AAA domain; Region: AAA_17; pfam13207 391037008363 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 391037008364 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 391037008365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037008366 Coenzyme A binding pocket [chemical binding]; other site 391037008367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037008368 putative DNA binding site [nucleotide binding]; other site 391037008369 putative Zn2+ binding site [ion binding]; other site 391037008370 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 391037008371 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 391037008372 Homeodomain-like domain; Region: HTH_23; pfam13384 391037008373 Winged helix-turn helix; Region: HTH_29; pfam13551 391037008374 Homeodomain-like domain; Region: HTH_32; pfam13565 391037008375 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037008376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037008377 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 391037008378 Cellulose binding domain; Region: CBM_2; pfam00553 391037008379 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 391037008380 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 391037008381 N- and C-terminal domain interface [polypeptide binding]; other site 391037008382 active site 391037008383 catalytic site [active] 391037008384 metal binding site [ion binding]; metal-binding site 391037008385 carbohydrate binding site [chemical binding]; other site 391037008386 ATP binding site [chemical binding]; other site 391037008387 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391037008388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391037008389 Glutamine amidotransferase class-I; Region: GATase; pfam00117 391037008390 conserved cys residue [active] 391037008391 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391037008392 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391037008393 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391037008394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037008395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037008396 catalytic residue [active] 391037008397 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037008398 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037008399 CBD_II domain; Region: CBD_II; smart00637 391037008400 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 391037008401 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 391037008402 putative active site [active] 391037008403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037008404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037008405 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008407 putative substrate translocation pore; other site 391037008408 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037008409 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 391037008410 nucleophilic elbow; other site 391037008411 catalytic triad; other site 391037008412 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 391037008413 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391037008414 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391037008415 short chain dehydrogenase; Provisional; Region: PRK06197 391037008416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008417 NAD(P) binding site [chemical binding]; other site 391037008418 active site 391037008419 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391037008420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391037008421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037008422 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391037008423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008424 putative substrate translocation pore; other site 391037008425 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 391037008426 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391037008427 putative ligand binding site [chemical binding]; other site 391037008428 putative NAD binding site [chemical binding]; other site 391037008429 catalytic site [active] 391037008430 haloalkane dehalogenase; Provisional; Region: PRK00870 391037008431 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037008432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037008433 motif II; other site 391037008434 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 391037008435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 391037008436 active site 391037008437 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391037008438 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 391037008439 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 391037008440 active site 391037008441 DNA binding site [nucleotide binding] 391037008442 catalytic site [active] 391037008443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037008444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037008445 dimer interface [polypeptide binding]; other site 391037008446 conserved gate region; other site 391037008447 ABC-ATPase subunit interface; other site 391037008448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037008449 dimer interface [polypeptide binding]; other site 391037008450 conserved gate region; other site 391037008451 putative PBP binding loops; other site 391037008452 ABC-ATPase subunit interface; other site 391037008453 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 391037008454 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037008455 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391037008456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391037008457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391037008458 putative active site [active] 391037008459 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 391037008460 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391037008461 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391037008462 hinge; other site 391037008463 active site 391037008464 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391037008465 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391037008466 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 391037008467 tetrameric interface [polypeptide binding]; other site 391037008468 NAD binding site [chemical binding]; other site 391037008469 catalytic residues [active] 391037008470 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 391037008471 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037008472 inhibitor-cofactor binding pocket; inhibition site 391037008473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037008474 catalytic residue [active] 391037008475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008476 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391037008477 NAD(P) binding site [chemical binding]; other site 391037008478 active site 391037008479 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391037008480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008481 NAD(P) binding site [chemical binding]; other site 391037008482 active site 391037008483 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 391037008484 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037008485 DNA binding residues [nucleotide binding] 391037008486 putative dimer interface [polypeptide binding]; other site 391037008487 HEAT repeats; Region: HEAT_2; pfam13646 391037008488 HEAT repeats; Region: HEAT_2; pfam13646 391037008489 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 391037008490 active site 391037008491 homodimer interface [polypeptide binding]; other site 391037008492 homotetramer interface [polypeptide binding]; other site 391037008493 Putative cyclase; Region: Cyclase; cl00814 391037008494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008495 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391037008496 NAD(P) binding site [chemical binding]; other site 391037008497 active site 391037008498 Rrf2 family protein; Region: rrf2_super; TIGR00738 391037008499 Transcriptional regulator; Region: Rrf2; pfam02082 391037008500 Transcriptional regulator; Region: Rrf2; cl17282 391037008501 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391037008502 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391037008503 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391037008504 Protein of unknown function (DUF742); Region: DUF742; pfam05331 391037008505 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 391037008506 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037008507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037008508 ATP binding site [chemical binding]; other site 391037008509 Mg2+ binding site [ion binding]; other site 391037008510 G-X-G motif; other site 391037008511 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 391037008512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037008513 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 391037008514 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391037008515 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391037008516 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391037008517 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037008518 thiamine pyrophosphate protein; Provisional; Region: PRK08273 391037008519 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 391037008520 PYR/PP interface [polypeptide binding]; other site 391037008521 dimer interface [polypeptide binding]; other site 391037008522 tetramer interface [polypeptide binding]; other site 391037008523 TPP binding site [chemical binding]; other site 391037008524 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391037008525 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391037008526 TPP-binding site [chemical binding]; other site 391037008527 Transglycosylase; Region: Transgly; pfam00912 391037008528 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391037008529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391037008530 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037008531 Cytochrome P450; Region: p450; cl12078 391037008532 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 391037008533 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 391037008534 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391037008535 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391037008536 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 391037008537 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 391037008538 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 391037008539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037008540 active site 391037008541 motif I; other site 391037008542 motif II; other site 391037008543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037008544 ferrochelatase; Reviewed; Region: hemH; PRK00035 391037008545 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391037008546 C-terminal domain interface [polypeptide binding]; other site 391037008547 active site 391037008548 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391037008549 active site 391037008550 N-terminal domain interface [polypeptide binding]; other site 391037008551 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 391037008552 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391037008553 NAD binding site [chemical binding]; other site 391037008554 homotetramer interface [polypeptide binding]; other site 391037008555 homodimer interface [polypeptide binding]; other site 391037008556 substrate binding site [chemical binding]; other site 391037008557 active site 391037008558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008559 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391037008560 NAD(P) binding site [chemical binding]; other site 391037008561 active site 391037008562 von Willebrand factor type A domain; Region: VWA_2; pfam13519 391037008563 metal ion-dependent adhesion site (MIDAS); other site 391037008564 Protein of unknown function DUF58; Region: DUF58; pfam01882 391037008565 MoxR-like ATPases [General function prediction only]; Region: COG0714 391037008566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037008567 Walker A motif; other site 391037008568 ATP binding site [chemical binding]; other site 391037008569 Walker B motif; other site 391037008570 arginine finger; other site 391037008571 Bacterial PH domain; Region: DUF304; cl01348 391037008572 Bacterial PH domain; Region: DUF304; pfam03703 391037008573 Bacterial PH domain; Region: DUF304; cl01348 391037008574 Bacterial PH domain; Region: DUF304; pfam03703 391037008575 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 391037008576 active site 391037008577 Predicted thioesterase [General function prediction only]; Region: COG5496 391037008578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391037008579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391037008580 MarR family; Region: MarR_2; pfam12802 391037008581 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 391037008582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037008583 Chitin binding domain; Region: Chitin_bind_3; pfam03067 391037008584 Cellulose binding domain; Region: CBM_2; pfam00553 391037008585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037008586 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 391037008587 active site 391037008588 catalytic residues [active] 391037008589 CHAT domain; Region: CHAT; pfam12770 391037008590 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391037008591 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391037008592 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037008593 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037008594 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037008595 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037008596 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037008597 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391037008598 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391037008599 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391037008600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037008601 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391037008602 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 391037008603 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391037008604 metal binding site [ion binding]; metal-binding site 391037008605 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 391037008606 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037008607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037008608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037008609 S-adenosylmethionine binding site [chemical binding]; other site 391037008610 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391037008611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037008612 acyl-activating enzyme (AAE) consensus motif; other site 391037008613 AMP binding site [chemical binding]; other site 391037008614 active site 391037008615 CoA binding site [chemical binding]; other site 391037008616 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037008618 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391037008619 active site 391037008620 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037008621 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037008622 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037008623 thioester reductase domain; Region: Thioester-redct; TIGR01746 391037008624 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 391037008625 putative NAD(P) binding site [chemical binding]; other site 391037008626 active site 391037008627 putative substrate binding site [chemical binding]; other site 391037008628 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391037008629 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037008630 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 391037008631 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 391037008632 active site 391037008633 dimer interface [polypeptide binding]; other site 391037008634 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 391037008635 Ligand Binding Site [chemical binding]; other site 391037008636 Molecular Tunnel; other site 391037008637 proline aminopeptidase P II; Provisional; Region: PRK10879 391037008638 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 391037008639 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 391037008640 active site 391037008641 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391037008642 aconitate hydratase; Validated; Region: PRK09277 391037008643 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391037008644 substrate binding site [chemical binding]; other site 391037008645 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391037008646 ligand binding site [chemical binding]; other site 391037008647 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 391037008648 substrate binding site [chemical binding]; other site 391037008649 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 391037008650 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 391037008651 ATP binding site [chemical binding]; other site 391037008652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037008653 motif I; other site 391037008654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037008655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037008656 TIGR04222 domain; Region: near_uncomplex 391037008657 hypothetical protein; Provisional; Region: PRK05409 391037008658 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391037008659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037008660 NAD(P) binding site [chemical binding]; other site 391037008661 active site 391037008662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391037008663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037008664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037008665 Walker A/P-loop; other site 391037008666 ATP binding site [chemical binding]; other site 391037008667 Q-loop/lid; other site 391037008668 ABC transporter signature motif; other site 391037008669 Walker B; other site 391037008670 D-loop; other site 391037008671 H-loop/switch region; other site 391037008672 enoyl-CoA hydratase; Provisional; Region: PRK06072 391037008673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037008674 substrate binding site [chemical binding]; other site 391037008675 oxyanion hole (OAH) forming residues; other site 391037008676 trimer interface [polypeptide binding]; other site 391037008677 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391037008678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037008679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037008680 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037008681 LysE type translocator; Region: LysE; cl00565 391037008682 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 391037008683 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 391037008684 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391037008685 trimerization site [polypeptide binding]; other site 391037008686 active site 391037008687 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391037008688 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391037008689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037008690 catalytic residue [active] 391037008691 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 391037008692 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 391037008693 Walker A/P-loop; other site 391037008694 ATP binding site [chemical binding]; other site 391037008695 Q-loop/lid; other site 391037008696 ABC transporter signature motif; other site 391037008697 Walker B; other site 391037008698 D-loop; other site 391037008699 H-loop/switch region; other site 391037008700 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 391037008701 [2Fe-2S] cluster binding site [ion binding]; other site 391037008702 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 391037008703 FeS assembly protein SufD; Region: sufD; TIGR01981 391037008704 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 391037008705 FeS assembly protein SufB; Region: sufB; TIGR01980 391037008706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037008707 dimerization interface [polypeptide binding]; other site 391037008708 Predicted transcriptional regulator [Transcription]; Region: COG2345 391037008709 putative DNA binding site [nucleotide binding]; other site 391037008710 putative Zn2+ binding site [ion binding]; other site 391037008711 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 391037008712 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 391037008713 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 391037008714 UbiA prenyltransferase family; Region: UbiA; pfam01040 391037008715 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 391037008716 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391037008717 TPP-binding site [chemical binding]; other site 391037008718 dimer interface [polypeptide binding]; other site 391037008719 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391037008720 PYR/PP interface [polypeptide binding]; other site 391037008721 dimer interface [polypeptide binding]; other site 391037008722 TPP binding site [chemical binding]; other site 391037008723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037008724 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 391037008725 putative active site [active] 391037008726 transaldolase; Provisional; Region: PRK03903 391037008727 catalytic residue [active] 391037008728 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 391037008729 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 391037008730 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 391037008731 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391037008732 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391037008733 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391037008734 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 391037008735 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 391037008736 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 391037008737 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 391037008738 putative active site [active] 391037008739 Preprotein translocase SecG subunit; Region: SecG; cl09123 391037008740 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391037008741 triosephosphate isomerase; Provisional; Region: PRK14565 391037008742 substrate binding site [chemical binding]; other site 391037008743 dimer interface [polypeptide binding]; other site 391037008744 catalytic triad [active] 391037008745 Phosphoglycerate kinase; Region: PGK; pfam00162 391037008746 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 391037008747 substrate binding site [chemical binding]; other site 391037008748 hinge regions; other site 391037008749 ADP binding site [chemical binding]; other site 391037008750 catalytic site [active] 391037008751 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391037008752 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 391037008753 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391037008754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 391037008755 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 391037008756 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 391037008757 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 391037008758 phosphate binding site [ion binding]; other site 391037008759 putative substrate binding pocket [chemical binding]; other site 391037008760 dimer interface [polypeptide binding]; other site 391037008761 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 391037008762 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 391037008763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037008764 S-adenosylmethionine binding site [chemical binding]; other site 391037008765 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 391037008766 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037008767 Ribosomally synthesized peptide in actinomycetes; Region: Actino_peptide; pfam14408 391037008768 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 391037008769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037008770 ATP binding site [chemical binding]; other site 391037008771 putative Mg++ binding site [ion binding]; other site 391037008772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037008773 nucleotide binding region [chemical binding]; other site 391037008774 ATP-binding site [chemical binding]; other site 391037008775 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 391037008776 HRDC domain; Region: HRDC; pfam00570 391037008777 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391037008778 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391037008779 GIY-YIG motif/motif A; other site 391037008780 active site 391037008781 catalytic site [active] 391037008782 putative DNA binding site [nucleotide binding]; other site 391037008783 metal binding site [ion binding]; metal-binding site 391037008784 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391037008785 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391037008786 Helix-hairpin-helix motif; Region: HHH; pfam00633 391037008787 helix-hairpin-helix signature motif; other site 391037008788 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 391037008789 iron-sulfur cluster [ion binding]; other site 391037008790 [2Fe-2S] cluster binding site [ion binding]; other site 391037008791 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391037008792 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391037008793 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391037008794 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 391037008795 Predicted GTPases [General function prediction only]; Region: COG1162 391037008796 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 391037008797 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391037008798 GTP/Mg2+ binding site [chemical binding]; other site 391037008799 G4 box; other site 391037008800 G5 box; other site 391037008801 G1 box; other site 391037008802 Switch I region; other site 391037008803 G2 box; other site 391037008804 G3 box; other site 391037008805 Switch II region; other site 391037008806 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 391037008807 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 391037008808 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391037008809 Short repeats of unknown function; Region: ALF; pfam03752 391037008810 Short repeats of unknown function; Region: ALF; pfam03752 391037008811 Short repeats of unknown function; Region: ALF; pfam03752 391037008812 Short repeats of unknown function; Region: ALF; pfam03752 391037008813 Short repeats of unknown function; Region: ALF; pfam03752 391037008814 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 391037008815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 391037008816 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 391037008817 Active_site [active] 391037008818 Trypsin; Region: Trypsin; pfam00089 391037008819 active site 391037008820 substrate binding sites [chemical binding]; other site 391037008821 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037008822 FAD binding domain; Region: FAD_binding_4; pfam01565 391037008823 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 391037008824 Predicted methyltransferase [General function prediction only]; Region: COG3897 391037008825 Predicted methyltransferase [General function prediction only]; Region: COG3897 391037008826 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037008827 DNA-binding site [nucleotide binding]; DNA binding site 391037008828 RNA-binding motif; other site 391037008829 Predicted acyl esterases [General function prediction only]; Region: COG2936 391037008830 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 391037008831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037008832 MarR family; Region: MarR; pfam01047 391037008833 MMPL family; Region: MMPL; pfam03176 391037008834 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391037008835 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391037008836 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391037008837 catalytic residue [active] 391037008838 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391037008839 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 391037008840 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 391037008841 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 391037008842 G1 box; other site 391037008843 putative GEF interaction site [polypeptide binding]; other site 391037008844 GTP/Mg2+ binding site [chemical binding]; other site 391037008845 Switch I region; other site 391037008846 G2 box; other site 391037008847 G3 box; other site 391037008848 Switch II region; other site 391037008849 G4 box; other site 391037008850 G5 box; other site 391037008851 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391037008852 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 391037008853 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 391037008854 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 391037008855 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 391037008856 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 391037008857 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391037008858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037008859 non-specific DNA binding site [nucleotide binding]; other site 391037008860 salt bridge; other site 391037008861 sequence-specific DNA binding site [nucleotide binding]; other site 391037008862 excinuclease ABC subunit B; Provisional; Region: PRK05298 391037008863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037008864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037008865 nucleotide binding region [chemical binding]; other site 391037008866 ATP-binding site [chemical binding]; other site 391037008867 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391037008868 UvrB/uvrC motif; Region: UVR; pfam02151 391037008869 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 391037008870 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391037008871 CoA-binding site [chemical binding]; other site 391037008872 ATP-binding [chemical binding]; other site 391037008873 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 391037008874 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 391037008875 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391037008876 RNA binding site [nucleotide binding]; other site 391037008877 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391037008878 RNA binding site [nucleotide binding]; other site 391037008879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391037008880 RNA binding site [nucleotide binding]; other site 391037008881 S1 RNA binding domain; Region: S1; pfam00575 391037008882 RNA binding site [nucleotide binding]; other site 391037008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037008884 S-adenosylmethionine binding site [chemical binding]; other site 391037008885 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 391037008886 DNA polymerase I; Provisional; Region: PRK05755 391037008887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391037008888 active site 391037008889 metal binding site 1 [ion binding]; metal-binding site 391037008890 putative 5' ssDNA interaction site; other site 391037008891 metal binding site 3; metal-binding site 391037008892 metal binding site 2 [ion binding]; metal-binding site 391037008893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391037008894 putative DNA binding site [nucleotide binding]; other site 391037008895 putative metal binding site [ion binding]; other site 391037008896 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 391037008897 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391037008898 active site 391037008899 DNA binding site [nucleotide binding] 391037008900 catalytic site [active] 391037008901 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391037008902 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391037008903 Walker A/P-loop; other site 391037008904 ATP binding site [chemical binding]; other site 391037008905 Q-loop/lid; other site 391037008906 ABC transporter signature motif; other site 391037008907 Walker B; other site 391037008908 D-loop; other site 391037008909 H-loop/switch region; other site 391037008910 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391037008911 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391037008912 Walker A/P-loop; other site 391037008913 ATP binding site [chemical binding]; other site 391037008914 Q-loop/lid; other site 391037008915 ABC transporter signature motif; other site 391037008916 Walker B; other site 391037008917 D-loop; other site 391037008918 H-loop/switch region; other site 391037008919 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391037008920 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391037008921 TM-ABC transporter signature motif; other site 391037008922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037008923 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391037008924 TM-ABC transporter signature motif; other site 391037008925 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391037008926 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391037008927 dimerization interface [polypeptide binding]; other site 391037008928 ligand binding site [chemical binding]; other site 391037008929 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391037008930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037008931 active site 391037008932 phosphorylation site [posttranslational modification] 391037008933 intermolecular recognition site; other site 391037008934 dimerization interface [polypeptide binding]; other site 391037008935 ANTAR domain; Region: ANTAR; pfam03861 391037008936 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037008937 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391037008938 putative DNA binding site [nucleotide binding]; other site 391037008939 putative Zn2+ binding site [ion binding]; other site 391037008940 AsnC family; Region: AsnC_trans_reg; pfam01037 391037008941 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391037008942 Predicted transcriptional regulator [Transcription]; Region: COG1959 391037008943 Transcriptional regulator; Region: Rrf2; pfam02082 391037008944 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 391037008945 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 391037008946 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 391037008947 active site 391037008948 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 391037008949 catalytic triad [active] 391037008950 dimer interface [polypeptide binding]; other site 391037008951 pyruvate kinase; Provisional; Region: PRK06247 391037008952 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 391037008953 domain interfaces; other site 391037008954 active site 391037008955 Lipase (class 2); Region: Lipase_2; pfam01674 391037008956 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 391037008957 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037008958 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037008959 Walker A/P-loop; other site 391037008960 ATP binding site [chemical binding]; other site 391037008961 Q-loop/lid; other site 391037008962 ABC transporter signature motif; other site 391037008963 Walker B; other site 391037008964 D-loop; other site 391037008965 H-loop/switch region; other site 391037008966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037008967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037008968 non-specific DNA binding site [nucleotide binding]; other site 391037008969 salt bridge; other site 391037008970 sequence-specific DNA binding site [nucleotide binding]; other site 391037008971 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 391037008972 active site 391037008973 catalytic triad [active] 391037008974 oxyanion hole [active] 391037008975 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 391037008976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037008977 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391037008978 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 391037008979 active site 391037008980 dimer interface [polypeptide binding]; other site 391037008981 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391037008982 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391037008983 active site 391037008984 FMN binding site [chemical binding]; other site 391037008985 substrate binding site [chemical binding]; other site 391037008986 3Fe-4S cluster binding site [ion binding]; other site 391037008987 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391037008988 domain interface; other site 391037008989 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037008990 hypothetical protein; Provisional; Region: PRK07236 391037008991 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 391037008992 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 391037008993 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 391037008994 substrate binding site [chemical binding]; other site 391037008995 active site 391037008996 catalytic residues [active] 391037008997 heterodimer interface [polypeptide binding]; other site 391037008998 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 391037008999 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391037009000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037009001 catalytic residue [active] 391037009002 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391037009003 active site 391037009004 ribulose/triose binding site [chemical binding]; other site 391037009005 phosphate binding site [ion binding]; other site 391037009006 substrate (anthranilate) binding pocket [chemical binding]; other site 391037009007 product (indole) binding pocket [chemical binding]; other site 391037009008 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 391037009009 anthranilate synthase component I; Provisional; Region: PRK13571 391037009010 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391037009011 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391037009012 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 391037009013 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 391037009014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037009015 Walker A/P-loop; other site 391037009016 ATP binding site [chemical binding]; other site 391037009017 Q-loop/lid; other site 391037009018 ABC transporter signature motif; other site 391037009019 Walker B; other site 391037009020 D-loop; other site 391037009021 H-loop/switch region; other site 391037009022 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037009023 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037009024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037009025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037009026 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391037009027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037009028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037009029 Walker A/P-loop; other site 391037009030 ATP binding site [chemical binding]; other site 391037009031 Q-loop/lid; other site 391037009032 ABC transporter signature motif; other site 391037009033 Walker B; other site 391037009034 D-loop; other site 391037009035 H-loop/switch region; other site 391037009036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037009037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037009038 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 391037009039 Walker A/P-loop; other site 391037009040 ATP binding site [chemical binding]; other site 391037009041 Q-loop/lid; other site 391037009042 ABC transporter signature motif; other site 391037009043 Walker B; other site 391037009044 D-loop; other site 391037009045 H-loop/switch region; other site 391037009046 TIGR03085 family protein; Region: TIGR03085 391037009047 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 391037009048 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 391037009049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037009050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037009051 homodimer interface [polypeptide binding]; other site 391037009052 catalytic residue [active] 391037009053 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 391037009054 Predicted membrane protein [Function unknown]; Region: COG2364 391037009055 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 391037009056 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391037009057 substrate binding site [chemical binding]; other site 391037009058 glutamase interaction surface [polypeptide binding]; other site 391037009059 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 391037009060 Prostaglandin dehydrogenases; Region: PGDH; cd05288 391037009061 NAD(P) binding site [chemical binding]; other site 391037009062 substrate binding site [chemical binding]; other site 391037009063 dimer interface [polypeptide binding]; other site 391037009064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037009065 MarR family; Region: MarR; pfam01047 391037009066 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391037009067 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391037009068 catalytic residues [active] 391037009069 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391037009070 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391037009071 putative active site [active] 391037009072 oxyanion strand; other site 391037009073 catalytic triad [active] 391037009074 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391037009075 putative active site pocket [active] 391037009076 4-fold oligomerization interface [polypeptide binding]; other site 391037009077 metal binding residues [ion binding]; metal-binding site 391037009078 3-fold/trimer interface [polypeptide binding]; other site 391037009079 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 391037009080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037009081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037009082 homodimer interface [polypeptide binding]; other site 391037009083 catalytic residue [active] 391037009084 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 391037009085 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391037009086 NAD binding site [chemical binding]; other site 391037009087 dimerization interface [polypeptide binding]; other site 391037009088 product binding site; other site 391037009089 substrate binding site [chemical binding]; other site 391037009090 zinc binding site [ion binding]; other site 391037009091 catalytic residues [active] 391037009092 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 391037009093 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 391037009094 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391037009095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037009096 RNA binding surface [nucleotide binding]; other site 391037009097 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391037009098 active site 391037009099 lipoprotein signal peptidase; Provisional; Region: PRK14764 391037009100 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 391037009101 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 391037009102 DivIVA protein; Region: DivIVA; pfam05103 391037009103 DivIVA domain; Region: DivI1A_domain; TIGR03544 391037009104 YGGT family; Region: YGGT; pfam02325 391037009105 Protein of unknown function (DUF552); Region: DUF552; pfam04472 391037009106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 391037009107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037009108 catalytic residue [active] 391037009109 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 391037009110 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 391037009111 nucleotide binding site [chemical binding]; other site 391037009112 SulA interaction site; other site 391037009113 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391037009114 Cell division protein FtsQ; Region: FtsQ; pfam03799 391037009115 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391037009116 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391037009117 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037009118 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391037009119 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391037009120 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391037009121 active site 391037009122 homodimer interface [polypeptide binding]; other site 391037009123 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 391037009124 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391037009125 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 391037009126 Mg++ binding site [ion binding]; other site 391037009127 putative catalytic motif [active] 391037009128 putative substrate binding site [chemical binding]; other site 391037009129 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391037009130 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 391037009131 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037009132 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391037009133 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391037009134 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391037009135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037009136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391037009137 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037009138 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391037009139 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391037009140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391037009141 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 391037009142 MraW methylase family; Region: Methyltransf_5; cl17771 391037009143 cell division protein MraZ; Reviewed; Region: PRK00326 391037009144 MraZ protein; Region: MraZ; pfam02381 391037009145 MraZ protein; Region: MraZ; pfam02381 391037009146 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037009147 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 391037009148 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391037009149 catalytic triad [active] 391037009150 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391037009151 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 391037009152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037009153 active site 391037009154 HIGH motif; other site 391037009155 nucleotide binding site [chemical binding]; other site 391037009156 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391037009157 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037009158 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037009159 active site 391037009160 KMSKS motif; other site 391037009161 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391037009162 tRNA binding surface [nucleotide binding]; other site 391037009163 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 391037009164 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 391037009165 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 391037009166 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 391037009167 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037009168 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 391037009169 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 391037009170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037009171 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 391037009172 MoxR-like ATPases [General function prediction only]; Region: COG0714 391037009173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037009174 Walker A motif; other site 391037009175 ATP binding site [chemical binding]; other site 391037009176 Walker B motif; other site 391037009177 arginine finger; other site 391037009178 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391037009179 Protein of unknown function DUF58; Region: DUF58; pfam01882 391037009180 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391037009181 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391037009182 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 391037009183 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391037009184 active site 391037009185 DNA polymerase IV; Validated; Region: PRK02406 391037009186 DNA binding site [nucleotide binding] 391037009187 Uncharacterized conserved protein [Function unknown]; Region: COG3379 391037009188 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 391037009189 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 391037009190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037009191 S-adenosylmethionine binding site [chemical binding]; other site 391037009192 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 391037009193 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 391037009194 active site 391037009195 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391037009196 generic binding surface II; other site 391037009197 generic binding surface I; other site 391037009198 Y-family of DNA polymerases; Region: PolY; cl12025 391037009199 active site 391037009200 DNA binding site [nucleotide binding] 391037009201 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 391037009202 putative deacylase active site [active] 391037009203 Protein of unknown function (DUF422); Region: DUF422; cl00991 391037009204 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 391037009205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037009206 active site 391037009207 phytoene desaturase; Region: crtI_fam; TIGR02734 391037009208 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 391037009209 FAD binding site [chemical binding]; other site 391037009210 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391037009211 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391037009212 substrate binding pocket [chemical binding]; other site 391037009213 chain length determination region; other site 391037009214 substrate-Mg2+ binding site; other site 391037009215 catalytic residues [active] 391037009216 aspartate-rich region 1; other site 391037009217 active site lid residues [active] 391037009218 aspartate-rich region 2; other site 391037009219 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037009220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037009221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391037009222 active site 391037009223 ATP binding site [chemical binding]; other site 391037009224 substrate binding site [chemical binding]; other site 391037009225 activation loop (A-loop); other site 391037009226 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037009227 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037009228 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037009229 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037009230 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037009231 AP endonuclease family 2; Region: AP2Ec; smart00518 391037009232 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 391037009233 AP (apurinic/apyrimidinic) site pocket; other site 391037009234 DNA interaction; other site 391037009235 Metal-binding active site; metal-binding site 391037009236 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 391037009237 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391037009238 tetramer interface [polypeptide binding]; other site 391037009239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037009240 catalytic residue [active] 391037009241 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391037009242 CBD_II domain; Region: CBD_II; smart00637 391037009243 Glyco_18 domain; Region: Glyco_18; smart00636 391037009244 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 391037009245 active site 391037009246 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 391037009247 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391037009248 Walker A/P-loop; other site 391037009249 ATP binding site [chemical binding]; other site 391037009250 Q-loop/lid; other site 391037009251 ABC transporter signature motif; other site 391037009252 Walker B; other site 391037009253 D-loop; other site 391037009254 H-loop/switch region; other site 391037009255 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391037009256 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391037009257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037009258 dimer interface [polypeptide binding]; other site 391037009259 conserved gate region; other site 391037009260 ABC-ATPase subunit interface; other site 391037009261 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391037009262 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391037009263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037009264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037009265 DNA binding site [nucleotide binding] 391037009266 domain linker motif; other site 391037009267 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391037009268 dimerization interface [polypeptide binding]; other site 391037009269 ligand binding site [chemical binding]; other site 391037009270 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391037009271 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 391037009272 putative substrate binding site [chemical binding]; other site 391037009273 putative ATP binding site [chemical binding]; other site 391037009274 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 391037009275 putative active cleft [active] 391037009276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037009277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037009278 dimer interface [polypeptide binding]; other site 391037009279 conserved gate region; other site 391037009280 putative PBP binding loops; other site 391037009281 ABC-ATPase subunit interface; other site 391037009282 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391037009283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037009284 ABC-ATPase subunit interface; other site 391037009285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037009286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391037009287 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037009288 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 391037009289 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 391037009290 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391037009291 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391037009292 phosphofructokinase; Region: PFK_mixed; TIGR02483 391037009293 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 391037009294 active site 391037009295 ADP/pyrophosphate binding site [chemical binding]; other site 391037009296 dimerization interface [polypeptide binding]; other site 391037009297 allosteric effector site; other site 391037009298 fructose-1,6-bisphosphate binding site; other site 391037009299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391037009300 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391037009301 ligand binding site [chemical binding]; other site 391037009302 flexible hinge region; other site 391037009303 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391037009304 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 391037009305 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 391037009306 active site 391037009307 homotetramer interface [polypeptide binding]; other site 391037009308 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037009309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 391037009310 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037009311 putative catalytic site [active] 391037009312 putative metal binding site [ion binding]; other site 391037009313 putative phosphate binding site [ion binding]; other site 391037009314 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391037009315 putative catalytic site [active] 391037009316 putative phosphate binding site [ion binding]; other site 391037009317 putative metal binding site [ion binding]; other site 391037009318 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 391037009319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391037009320 nucleotide binding site [chemical binding]; other site 391037009321 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 391037009322 putative hydrophobic ligand binding site [chemical binding]; other site 391037009323 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391037009324 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391037009325 acyl-activating enzyme (AAE) consensus motif; other site 391037009326 putative AMP binding site [chemical binding]; other site 391037009327 putative active site [active] 391037009328 putative CoA binding site [chemical binding]; other site 391037009329 GAF domain; Region: GAF_3; pfam13492 391037009330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 391037009331 Histidine kinase; Region: HisKA_3; pfam07730 391037009332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037009333 ATP binding site [chemical binding]; other site 391037009334 Mg2+ binding site [ion binding]; other site 391037009335 G-X-G motif; other site 391037009336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037009337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037009338 active site 391037009339 phosphorylation site [posttranslational modification] 391037009340 intermolecular recognition site; other site 391037009341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037009342 DNA binding residues [nucleotide binding] 391037009343 dimerization interface [polypeptide binding]; other site 391037009344 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037009345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037009346 S-adenosylmethionine binding site [chemical binding]; other site 391037009347 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037009348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037009349 metal binding site [ion binding]; metal-binding site 391037009350 active site 391037009351 I-site; other site 391037009352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037009353 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037009354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037009355 Peptidase family M48; Region: Peptidase_M48; cl12018 391037009356 YacP-like NYN domain; Region: NYN_YacP; cl01491 391037009357 hypothetical protein; Validated; Region: PRK07883 391037009358 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 391037009359 active site 391037009360 catalytic site [active] 391037009361 substrate binding site [chemical binding]; other site 391037009362 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391037009363 GIY-YIG motif/motif A; other site 391037009364 active site 391037009365 catalytic site [active] 391037009366 putative DNA binding site [nucleotide binding]; other site 391037009367 metal binding site [ion binding]; metal-binding site 391037009368 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391037009369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391037009370 Zn2+ binding site [ion binding]; other site 391037009371 Mg2+ binding site [ion binding]; other site 391037009372 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391037009373 synthetase active site [active] 391037009374 NTP binding site [chemical binding]; other site 391037009375 metal binding site [ion binding]; metal-binding site 391037009376 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391037009377 NUDIX domain; Region: NUDIX; pfam00293 391037009378 nudix motif; other site 391037009379 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391037009380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037009381 active site 391037009382 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037009383 AsnC family; Region: AsnC_trans_reg; pfam01037 391037009384 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 391037009385 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 391037009386 intrachain domain interface; other site 391037009387 interchain domain interface [polypeptide binding]; other site 391037009388 heme bL binding site [chemical binding]; other site 391037009389 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 391037009390 heme bH binding site [chemical binding]; other site 391037009391 Qo binding site; other site 391037009392 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 391037009393 iron-sulfur cluster [ion binding]; other site 391037009394 [2Fe-2S] cluster binding site [ion binding]; other site 391037009395 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391037009396 Cytochrome c; Region: Cytochrom_C; pfam00034 391037009397 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391037009398 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391037009399 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 391037009400 Subunit I/III interface [polypeptide binding]; other site 391037009401 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 391037009402 Transferrin; Region: Transferrin; cl02460 391037009403 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 391037009404 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391037009405 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391037009406 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 391037009407 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 391037009408 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391037009409 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037009410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 391037009411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037009412 catalytic residue [active] 391037009413 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 391037009414 CPxP motif; other site 391037009415 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 391037009416 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391037009417 substrate binding site [chemical binding]; other site 391037009418 ATP binding site [chemical binding]; other site 391037009419 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 391037009420 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 391037009421 quinolinate synthetase; Provisional; Region: PRK09375 391037009422 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391037009423 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391037009424 hinge; other site 391037009425 active site 391037009426 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 391037009427 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 391037009428 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 391037009429 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037009430 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037009431 active site 391037009432 catalytic tetrad [active] 391037009433 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 391037009434 active site 391037009435 putative substrate binding region [chemical binding]; other site 391037009436 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 391037009437 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 391037009438 active site pocket [active] 391037009439 cobalamin synthase; Reviewed; Region: cobS; PRK00235 391037009440 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 391037009441 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 391037009442 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391037009443 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391037009444 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391037009445 interface (dimer of trimers) [polypeptide binding]; other site 391037009446 Substrate-binding/catalytic site; other site 391037009447 Zn-binding sites [ion binding]; other site 391037009448 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391037009449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037009450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391037009451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037009452 E3 interaction surface; other site 391037009453 lipoyl attachment site [posttranslational modification]; other site 391037009454 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037009455 E3 interaction surface; other site 391037009456 lipoyl attachment site [posttranslational modification]; other site 391037009457 e3 binding domain; Region: E3_binding; pfam02817 391037009458 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 391037009459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391037009460 prolyl-tRNA synthetase; Provisional; Region: PRK09194 391037009461 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037009462 motif 1; other site 391037009463 dimer interface [polypeptide binding]; other site 391037009464 active site 391037009465 motif 2; other site 391037009466 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 391037009467 putative deacylase active site [active] 391037009468 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037009469 active site 391037009470 motif 3; other site 391037009471 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 391037009472 anticodon binding site; other site 391037009473 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 391037009474 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391037009475 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 391037009476 DNA binding residues [nucleotide binding] 391037009477 putative dimer interface [polypeptide binding]; other site 391037009478 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 391037009479 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 391037009480 putative active site [active] 391037009481 putative metal binding site [ion binding]; other site 391037009482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037009483 active site 391037009484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037009485 catalytic tetrad [active] 391037009486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037009487 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 391037009488 NAD(P) binding site [chemical binding]; other site 391037009489 active site 391037009490 lipoate-protein ligase B; Provisional; Region: PRK14345 391037009491 lipoyl synthase; Provisional; Region: PRK05481 391037009492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037009493 FeS/SAM binding site; other site 391037009494 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 391037009495 active site 391037009496 dimer interface [polypeptide binding]; other site 391037009497 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 391037009498 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 391037009499 heme-binding site [chemical binding]; other site 391037009500 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 391037009501 FAD binding pocket [chemical binding]; other site 391037009502 FAD binding motif [chemical binding]; other site 391037009503 phosphate binding motif [ion binding]; other site 391037009504 beta-alpha-beta structure motif; other site 391037009505 NAD binding pocket [chemical binding]; other site 391037009506 V-type ATP synthase subunit E; Provisional; Region: PRK01005 391037009507 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 391037009508 RDD family; Region: RDD; pfam06271 391037009509 glutamine synthetase, type I; Region: GlnA; TIGR00653 391037009510 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391037009511 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391037009512 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037009513 Homeodomain-like domain; Region: HTH_23; pfam13384 391037009514 Winged helix-turn helix; Region: HTH_29; pfam13551 391037009515 Homeodomain-like domain; Region: HTH_32; pfam13565 391037009516 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037009517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037009518 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 391037009519 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 391037009520 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 391037009521 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391037009522 metal binding triad; other site 391037009523 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391037009524 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391037009525 metal binding triad; other site 391037009526 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391037009527 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 391037009528 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391037009529 catalytic triad [active] 391037009530 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 391037009531 dimer interface [polypeptide binding]; other site 391037009532 catalytic triad [active] 391037009533 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391037009534 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391037009535 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391037009536 NAD synthetase; Provisional; Region: PRK13981 391037009537 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391037009538 multimer interface [polypeptide binding]; other site 391037009539 active site 391037009540 catalytic triad [active] 391037009541 protein interface 1 [polypeptide binding]; other site 391037009542 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 391037009543 homodimer interface [polypeptide binding]; other site 391037009544 NAD binding pocket [chemical binding]; other site 391037009545 ATP binding pocket [chemical binding]; other site 391037009546 Mg binding site [ion binding]; other site 391037009547 active-site loop [active] 391037009548 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 391037009549 oligomerization interface [polypeptide binding]; other site 391037009550 active site 391037009551 metal binding site [ion binding]; metal-binding site 391037009552 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391037009553 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 391037009554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037009555 S-adenosylmethionine binding site [chemical binding]; other site 391037009556 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 391037009557 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391037009558 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 391037009559 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 391037009560 RNA/DNA hybrid binding site [nucleotide binding]; other site 391037009561 active site 391037009562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037009563 catalytic core [active] 391037009564 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 391037009565 Putative zinc ribbon domain; Region: DUF164; pfam02591 391037009566 Uncharacterized conserved protein [Function unknown]; Region: COG0327 391037009567 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 391037009568 Flavoprotein; Region: Flavoprotein; pfam02441 391037009569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037009570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037009571 non-specific DNA binding site [nucleotide binding]; other site 391037009572 salt bridge; other site 391037009573 sequence-specific DNA binding site [nucleotide binding]; other site 391037009574 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 391037009575 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 391037009576 Uncharacterized conserved protein [Function unknown]; Region: COG4279 391037009577 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391037009578 SNF2 Helicase protein; Region: DUF3670; pfam12419 391037009579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037009580 ATP binding site [chemical binding]; other site 391037009581 putative Mg++ binding site [ion binding]; other site 391037009582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037009583 nucleotide binding region [chemical binding]; other site 391037009584 ATP-binding site [chemical binding]; other site 391037009585 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 391037009586 PGAP1-like protein; Region: PGAP1; pfam07819 391037009587 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037009588 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 391037009589 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391037009590 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 391037009591 dimer interface [polypeptide binding]; other site 391037009592 catalytic triad [active] 391037009593 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 391037009594 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391037009595 TPP-binding site [chemical binding]; other site 391037009596 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391037009597 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391037009598 PYR/PP interface [polypeptide binding]; other site 391037009599 dimer interface [polypeptide binding]; other site 391037009600 TPP binding site [chemical binding]; other site 391037009601 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391037009602 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391037009603 MarR family; Region: MarR_2; pfam12802 391037009604 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 391037009605 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 391037009606 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 391037009607 dimer interface [polypeptide binding]; other site 391037009608 TPP-binding site [chemical binding]; other site 391037009609 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 391037009610 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391037009611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037009612 active site 391037009613 HIGH motif; other site 391037009614 nucleotide binding site [chemical binding]; other site 391037009615 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391037009616 active site 391037009617 KMSKS motif; other site 391037009618 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391037009619 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391037009620 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391037009621 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391037009622 E3 interaction surface; other site 391037009623 lipoyl attachment site [posttranslational modification]; other site 391037009624 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391037009625 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391037009626 dimer interface [polypeptide binding]; other site 391037009627 active site 391037009628 CoA binding pocket [chemical binding]; other site 391037009629 acyl carrier protein; Provisional; Region: acpP; PRK00982 391037009630 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391037009631 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391037009632 dimer interface [polypeptide binding]; other site 391037009633 active site 391037009634 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391037009635 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391037009636 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391037009637 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 391037009638 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 391037009639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037009640 Part of AAA domain; Region: AAA_19; pfam13245 391037009641 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391037009642 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391037009643 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 391037009644 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037009645 anti sigma factor interaction site; other site 391037009646 regulatory phosphorylation site [posttranslational modification]; other site 391037009647 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 391037009648 BON domain; Region: BON; pfam04972 391037009649 BON domain; Region: BON; pfam04972 391037009650 BON domain; Region: BON; pfam04972 391037009651 Thioredoxin; Region: Thioredoxin_4; cl17273 391037009652 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391037009653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037009654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037009655 DNA binding residues [nucleotide binding] 391037009656 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 391037009657 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391037009658 NAD binding site [chemical binding]; other site 391037009659 catalytic Zn binding site [ion binding]; other site 391037009660 structural Zn binding site [ion binding]; other site 391037009661 Uncharacterized conserved protein [Function unknown]; Region: COG3268 391037009662 seryl-tRNA synthetase; Provisional; Region: PRK05431 391037009663 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037009664 motif 1; other site 391037009665 dimer interface [polypeptide binding]; other site 391037009666 active site 391037009667 motif 2; other site 391037009668 motif 3; other site 391037009669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037009670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037009671 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037009672 active site 391037009673 metal binding site [ion binding]; metal-binding site 391037009674 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391037009675 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391037009676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391037009677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391037009678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391037009679 dimerization interface [polypeptide binding]; other site 391037009680 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 391037009681 Peptidase family M50; Region: Peptidase_M50; pfam02163 391037009682 active site 391037009683 putative substrate binding region [chemical binding]; other site 391037009684 FOG: CBS domain [General function prediction only]; Region: COG0517 391037009685 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 391037009686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391037009687 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391037009688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037009689 non-specific DNA binding site [nucleotide binding]; other site 391037009690 salt bridge; other site 391037009691 sequence-specific DNA binding site [nucleotide binding]; other site 391037009692 Cupin domain; Region: Cupin_2; pfam07883 391037009693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037009694 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037009695 active site 391037009696 catalytic tetrad [active] 391037009697 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037009698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037009699 putative substrate translocation pore; other site 391037009700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037009701 Radical SAM superfamily; Region: Radical_SAM; pfam04055 391037009702 FeS/SAM binding site; other site 391037009703 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 391037009704 Replication-relaxation; Region: Replic_Relax; pfam13814 391037009705 Predicted membrane protein [Function unknown]; Region: COG3371 391037009706 Protein of unknown function (DUF998); Region: DUF998; pfam06197 391037009707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391037009708 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037009709 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 391037009710 DNA binding residues [nucleotide binding] 391037009711 dimer interface [polypeptide binding]; other site 391037009712 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391037009713 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391037009714 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037009715 AAA ATPase domain; Region: AAA_16; pfam13191 391037009716 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 391037009717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037009718 binding surface 391037009719 TPR motif; other site 391037009720 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037009721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037009722 binding surface 391037009723 TPR motif; other site 391037009724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037009725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391037009726 Calx-beta domain; Region: Calx-beta; cl02522 391037009727 Calx-beta domain; Region: Calx-beta; cl02522 391037009728 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037009729 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 391037009730 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391037009731 putative active site [active] 391037009732 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037009733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037009734 non-specific DNA binding site [nucleotide binding]; other site 391037009735 salt bridge; other site 391037009736 sequence-specific DNA binding site [nucleotide binding]; other site 391037009737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037009738 active site 391037009739 Int/Topo IB signature motif; other site 391037009740 DNA binding site [nucleotide binding] 391037009741 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 391037009742 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037009743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037009744 non-specific DNA binding site [nucleotide binding]; other site 391037009745 salt bridge; other site 391037009746 sequence-specific DNA binding site [nucleotide binding]; other site 391037009747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037009748 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391037009749 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391037009750 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 391037009751 Phage-related protein [Function unknown]; Region: COG4695; cl01923 391037009752 Phage portal protein; Region: Phage_portal; pfam04860 391037009753 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 391037009754 active site 391037009755 hypothetical protein; Provisional; Region: PRK14709 391037009756 D5 N terminal like; Region: D5_N; pfam08706 391037009757 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 391037009758 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391037009759 Prophage antirepressor [Transcription]; Region: COG3617 391037009760 BRO family, N-terminal domain; Region: Bro-N; smart01040 391037009761 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 391037009762 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037009763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037009764 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037009765 DNA binding site [nucleotide binding] 391037009766 Int/Topo IB signature motif; other site 391037009767 active site 391037009768 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 391037009769 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037009770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037009771 non-specific DNA binding site [nucleotide binding]; other site 391037009772 salt bridge; other site 391037009773 sequence-specific DNA binding site [nucleotide binding]; other site 391037009774 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037009775 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391037009776 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391037009777 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 391037009778 Phage-related protein [Function unknown]; Region: COG4695; cl01923 391037009779 Phage portal protein; Region: Phage_portal; pfam04860 391037009780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 391037009781 active site 391037009782 hypothetical protein; Provisional; Region: PRK14709 391037009783 D5 N terminal like; Region: D5_N; pfam08706 391037009784 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 391037009785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391037009786 Prophage antirepressor [Transcription]; Region: COG3617 391037009787 BRO family, N-terminal domain; Region: Bro-N; smart01040 391037009788 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 391037009789 Helix-turn-helix domain; Region: HTH_17; pfam12728 391037009790 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037009791 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391037009792 DNA binding site [nucleotide binding] 391037009793 Int/Topo IB signature motif; other site 391037009794 active site 391037009795 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391037009796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391037009797 MMPL family; Region: MMPL; pfam03176 391037009798 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037009799 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037009800 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037009801 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037009802 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037009803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037009804 Walker A/P-loop; other site 391037009805 ATP binding site [chemical binding]; other site 391037009806 Q-loop/lid; other site 391037009807 ABC transporter signature motif; other site 391037009808 Walker B; other site 391037009809 D-loop; other site 391037009810 H-loop/switch region; other site 391037009811 DNA primase; Validated; Region: dnaG; PRK05667 391037009812 CHC2 zinc finger; Region: zf-CHC2; pfam01807 391037009813 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391037009814 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391037009815 active site 391037009816 metal binding site [ion binding]; metal-binding site 391037009817 interdomain interaction site; other site 391037009818 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391037009819 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 391037009820 BCCT family transporter; Region: BCCT; pfam02028 391037009821 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 391037009822 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 391037009823 FAD binding pocket [chemical binding]; other site 391037009824 FAD binding motif [chemical binding]; other site 391037009825 phosphate binding motif [ion binding]; other site 391037009826 NAD binding pocket [chemical binding]; other site 391037009827 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 391037009828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391037009829 Zn2+ binding site [ion binding]; other site 391037009830 Mg2+ binding site [ion binding]; other site 391037009831 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 391037009832 pyruvate phosphate dikinase; Provisional; Region: PRK09279 391037009833 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391037009834 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391037009835 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391037009836 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391037009837 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 391037009838 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 391037009839 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 391037009840 active site 391037009841 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 391037009842 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 391037009843 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391037009844 FMN binding site [chemical binding]; other site 391037009845 active site 391037009846 catalytic residues [active] 391037009847 substrate binding site [chemical binding]; other site 391037009848 glycyl-tRNA synthetase; Provisional; Region: PRK04173 391037009849 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037009850 motif 1; other site 391037009851 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 391037009852 active site 391037009853 motif 2; other site 391037009854 motif 3; other site 391037009855 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 391037009856 anticodon binding site; other site 391037009857 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391037009858 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391037009859 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 391037009860 intersubunit interface [polypeptide binding]; other site 391037009861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037009862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037009863 Walker A/P-loop; other site 391037009864 ATP binding site [chemical binding]; other site 391037009865 Q-loop/lid; other site 391037009866 ABC transporter signature motif; other site 391037009867 Walker B; other site 391037009868 D-loop; other site 391037009869 H-loop/switch region; other site 391037009870 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391037009871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037009872 dimer interface [polypeptide binding]; other site 391037009873 putative PBP binding regions; other site 391037009874 ABC-ATPase subunit interface; other site 391037009875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037009876 dimerization interface [polypeptide binding]; other site 391037009877 putative DNA binding site [nucleotide binding]; other site 391037009878 putative Zn2+ binding site [ion binding]; other site 391037009879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037009880 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037009881 active site 391037009882 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037009883 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391037009884 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 391037009885 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037009886 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391037009887 Walker A/P-loop; other site 391037009888 ATP binding site [chemical binding]; other site 391037009889 Q-loop/lid; other site 391037009890 ABC transporter signature motif; other site 391037009891 Walker B; other site 391037009892 D-loop; other site 391037009893 H-loop/switch region; other site 391037009894 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 391037009895 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391037009896 Walker A/P-loop; other site 391037009897 ATP binding site [chemical binding]; other site 391037009898 Q-loop/lid; other site 391037009899 ABC transporter signature motif; other site 391037009900 Walker B; other site 391037009901 D-loop; other site 391037009902 H-loop/switch region; other site 391037009903 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 391037009904 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391037009905 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 391037009906 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 391037009907 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 391037009908 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 391037009909 catalytic residue [active] 391037009910 putative FPP diphosphate binding site; other site 391037009911 putative FPP binding hydrophobic cleft; other site 391037009912 dimer interface [polypeptide binding]; other site 391037009913 putative IPP diphosphate binding site; other site 391037009914 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391037009915 Recombination protein O N terminal; Region: RecO_N; pfam11967 391037009916 Recombination protein O C terminal; Region: RecO_C; pfam02565 391037009917 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391037009918 OpgC protein; Region: OpgC_C; cl17858 391037009919 GTPase Era; Reviewed; Region: era; PRK00089 391037009920 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 391037009921 G1 box; other site 391037009922 GTP/Mg2+ binding site [chemical binding]; other site 391037009923 Switch I region; other site 391037009924 G2 box; other site 391037009925 Switch II region; other site 391037009926 G3 box; other site 391037009927 G4 box; other site 391037009928 G5 box; other site 391037009929 KH domain; Region: KH_2; pfam07650 391037009930 Domain of unknown function DUF21; Region: DUF21; pfam01595 391037009931 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 391037009932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391037009933 Transporter associated domain; Region: CorC_HlyC; smart01091 391037009934 metal-binding heat shock protein; Provisional; Region: PRK00016 391037009935 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 391037009936 PhoH-like protein; Region: PhoH; pfam02562 391037009937 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 391037009938 nucleotide binding site/active site [active] 391037009939 HIT family signature motif; other site 391037009940 catalytic residue [active] 391037009941 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 391037009942 RNA methyltransferase, RsmE family; Region: TIGR00046 391037009943 chaperone protein DnaJ; Provisional; Region: PRK14278 391037009944 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391037009945 HSP70 interaction site [polypeptide binding]; other site 391037009946 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391037009947 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391037009948 dimer interface [polypeptide binding]; other site 391037009949 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391037009950 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391037009951 Tic20-like protein; Region: Tic20; pfam09685 391037009952 coproporphyrinogen III oxidase; Validated; Region: PRK05628 391037009953 enoyl-CoA hydratase; Provisional; Region: PRK07827 391037009954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037009955 substrate binding site [chemical binding]; other site 391037009956 oxyanion hole (OAH) forming residues; other site 391037009957 trimer interface [polypeptide binding]; other site 391037009958 GTP-binding protein LepA; Provisional; Region: PRK05433 391037009959 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 391037009960 G1 box; other site 391037009961 putative GEF interaction site [polypeptide binding]; other site 391037009962 GTP/Mg2+ binding site [chemical binding]; other site 391037009963 Switch I region; other site 391037009964 G2 box; other site 391037009965 G3 box; other site 391037009966 Switch II region; other site 391037009967 G4 box; other site 391037009968 G5 box; other site 391037009969 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 391037009970 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391037009971 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391037009972 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 391037009973 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391037009974 Phosphotransferase enzyme family; Region: APH; pfam01636 391037009975 active site 391037009976 ATP binding site [chemical binding]; other site 391037009977 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 391037009978 substrate binding site [chemical binding]; other site 391037009979 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 391037009980 hypothetical protein; Reviewed; Region: PRK07914 391037009981 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 391037009982 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 391037009983 Competence protein; Region: Competence; pfam03772 391037009984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391037009985 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 391037009986 Helix-hairpin-helix motif; Region: HHH; pfam00633 391037009987 EDD domain protein, DegV family; Region: DegV; TIGR00762 391037009988 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 391037009989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037009990 catalytic core [active] 391037009991 Oligomerisation domain; Region: Oligomerisation; pfam02410 391037009992 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 391037009993 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 391037009994 active site 391037009995 (T/H)XGH motif; other site 391037009996 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037009997 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 391037009998 GTPase CgtA; Reviewed; Region: obgE; PRK12296 391037009999 GTP1/OBG; Region: GTP1_OBG; pfam01018 391037010000 Obg GTPase; Region: Obg; cd01898 391037010001 G1 box; other site 391037010002 GTP/Mg2+ binding site [chemical binding]; other site 391037010003 Switch I region; other site 391037010004 G2 box; other site 391037010005 G3 box; other site 391037010006 Switch II region; other site 391037010007 G4 box; other site 391037010008 G5 box; other site 391037010009 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 391037010010 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 391037010011 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 391037010012 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 391037010013 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391037010014 homodimer interface [polypeptide binding]; other site 391037010015 oligonucleotide binding site [chemical binding]; other site 391037010016 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 391037010017 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 391037010018 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 391037010019 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391037010020 B12 binding site [chemical binding]; other site 391037010021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037010022 FeS/SAM binding site; other site 391037010023 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037010024 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391037010025 putative acyl-acceptor binding pocket; other site 391037010026 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 391037010027 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391037010028 HIGH motif; other site 391037010029 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391037010030 active site 391037010031 KMSKS motif; other site 391037010032 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 391037010033 tRNA binding surface [nucleotide binding]; other site 391037010034 anticodon binding site; other site 391037010035 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 391037010036 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 391037010037 putative active site [active] 391037010038 putative metal binding site [ion binding]; other site 391037010039 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391037010040 active site 391037010041 multimer interface [polypeptide binding]; other site 391037010042 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037010043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037010044 active site 391037010045 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 391037010046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391037010047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391037010048 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 391037010049 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391037010050 HIGH motif; other site 391037010051 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391037010052 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391037010053 active site 391037010054 KMSKS motif; other site 391037010055 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391037010056 tRNA binding surface [nucleotide binding]; other site 391037010057 anticodon binding site; other site 391037010058 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391037010059 nitrilase; Region: PLN02798 391037010060 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391037010061 putative active site [active] 391037010062 catalytic triad [active] 391037010063 dimer interface [polypeptide binding]; other site 391037010064 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391037010065 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391037010066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037010067 Walker A motif; other site 391037010068 ATP binding site [chemical binding]; other site 391037010069 Walker B motif; other site 391037010070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391037010071 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 391037010072 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391037010073 oligomer interface [polypeptide binding]; other site 391037010074 active site residues [active] 391037010075 Clp protease; Region: CLP_protease; pfam00574 391037010076 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391037010077 oligomer interface [polypeptide binding]; other site 391037010078 active site residues [active] 391037010079 trigger factor; Provisional; Region: tig; PRK01490 391037010080 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391037010081 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391037010082 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037010083 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037010084 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 391037010085 putative NAD(P) binding site [chemical binding]; other site 391037010086 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037010087 dimerization interface [polypeptide binding]; other site 391037010088 putative DNA binding site [nucleotide binding]; other site 391037010089 putative Zn2+ binding site [ion binding]; other site 391037010090 hypothetical protein; Provisional; Region: PRK01346 391037010091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037010092 Coenzyme A binding pocket [chemical binding]; other site 391037010093 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 391037010094 Uncharacterized conserved protein [Function unknown]; Region: COG4198 391037010095 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391037010096 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 391037010097 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 391037010098 Zn binding site [ion binding]; other site 391037010099 Repair protein; Region: Repair_PSII; pfam04536 391037010100 amidase; Provisional; Region: PRK07869 391037010101 Amidase; Region: Amidase; cl11426 391037010102 Amidohydrolase; Region: Amidohydro_2; pfam04909 391037010103 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 391037010104 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391037010105 homotrimer interaction site [polypeptide binding]; other site 391037010106 putative active site [active] 391037010107 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391037010108 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 391037010109 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 391037010110 active site 391037010111 catalytic residues [active] 391037010112 metal binding site [ion binding]; metal-binding site 391037010113 DmpG-like communication domain; Region: DmpG_comm; pfam07836 391037010114 acetaldehyde dehydrogenase; Validated; Region: PRK08300 391037010115 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391037010116 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 391037010117 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391037010118 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 391037010119 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 391037010120 NAD binding site [chemical binding]; other site 391037010121 catalytic residues [active] 391037010122 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037010123 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391037010124 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391037010125 kynureninase; Region: kynureninase; TIGR01814 391037010126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037010127 catalytic residue [active] 391037010128 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 391037010129 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391037010130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037010131 putative DNA binding site [nucleotide binding]; other site 391037010132 putative Zn2+ binding site [ion binding]; other site 391037010133 AsnC family; Region: AsnC_trans_reg; pfam01037 391037010134 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 391037010135 active site 391037010136 putative catalytic site [active] 391037010137 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 391037010138 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391037010139 active site 391037010140 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391037010141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391037010142 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037010143 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 391037010144 apolar tunnel; other site 391037010145 heme binding site [chemical binding]; other site 391037010146 dimerization interface [polypeptide binding]; other site 391037010147 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 391037010148 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391037010149 active site 391037010150 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391037010151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037010152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037010153 ABC transporter; Region: ABC_tran_2; pfam12848 391037010154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037010155 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 391037010156 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 391037010157 active site 391037010158 homotetramer interface [polypeptide binding]; other site 391037010159 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 391037010160 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 391037010161 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 391037010162 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 391037010163 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391037010164 homodimer interface [polypeptide binding]; other site 391037010165 active site 391037010166 SAM binding site [chemical binding]; other site 391037010167 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 391037010168 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 391037010169 putative dimer interface [polypeptide binding]; other site 391037010170 active site pocket [active] 391037010171 putative cataytic base [active] 391037010172 hypothetical protein; Provisional; Region: PRK07908 391037010173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037010174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037010175 homodimer interface [polypeptide binding]; other site 391037010176 catalytic residue [active] 391037010177 Transglycosylase; Region: Transgly; pfam00912 391037010178 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391037010179 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391037010180 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391037010181 hypothetical protein; Provisional; Region: PRK07907 391037010182 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 391037010183 active site 391037010184 metal binding site [ion binding]; metal-binding site 391037010185 dimer interface [polypeptide binding]; other site 391037010186 hypothetical protein; Provisional; Region: PRK06547 391037010187 cobyric acid synthase; Provisional; Region: PRK00784 391037010188 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391037010189 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391037010190 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391037010191 catalytic triad [active] 391037010192 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 391037010193 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391037010194 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391037010195 dimer interface [polypeptide binding]; other site 391037010196 ssDNA binding site [nucleotide binding]; other site 391037010197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391037010198 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 391037010199 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037010200 YHYH protein; Region: YHYH; pfam14240 391037010201 RibD C-terminal domain; Region: RibD_C; cl17279 391037010202 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037010203 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 391037010204 DNA binding residues [nucleotide binding] 391037010205 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391037010206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037010207 putative acyl-acceptor binding pocket; other site 391037010208 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 391037010209 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 391037010210 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391037010211 FOG: CBS domain [General function prediction only]; Region: COG0517 391037010212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 391037010213 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 391037010214 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391037010215 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391037010216 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391037010217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391037010218 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391037010219 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391037010220 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391037010221 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 391037010222 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 391037010223 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391037010224 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 391037010225 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 391037010226 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391037010227 NlpC/P60 family; Region: NLPC_P60; pfam00877 391037010228 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 391037010229 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391037010230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037010231 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391037010232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037010233 DNA binding residues [nucleotide binding] 391037010234 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391037010235 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391037010236 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391037010237 putative active site [active] 391037010238 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 391037010239 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391037010240 active site 391037010241 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391037010242 active site 391037010243 metal binding site [ion binding]; metal-binding site 391037010244 TspO/MBR family; Region: TspO_MBR; pfam03073 391037010245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391037010246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010247 dimer interface [polypeptide binding]; other site 391037010248 conserved gate region; other site 391037010249 putative PBP binding loops; other site 391037010250 ABC-ATPase subunit interface; other site 391037010251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391037010252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010253 dimer interface [polypeptide binding]; other site 391037010254 conserved gate region; other site 391037010255 putative PBP binding loops; other site 391037010256 ABC-ATPase subunit interface; other site 391037010257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391037010258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391037010259 DNA binding site [nucleotide binding] 391037010260 domain linker motif; other site 391037010261 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391037010262 ligand binding site [chemical binding]; other site 391037010263 dimerization interface [polypeptide binding]; other site 391037010264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037010265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037010266 putative substrate translocation pore; other site 391037010267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391037010268 D-xylulose kinase; Region: XylB; TIGR01312 391037010269 nucleotide binding site [chemical binding]; other site 391037010270 xylose isomerase; Provisional; Region: PRK12677 391037010271 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 391037010272 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 391037010273 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391037010274 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391037010275 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391037010276 metal ion-dependent adhesion site (MIDAS); other site 391037010277 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 391037010278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 391037010279 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 391037010280 G1 box; other site 391037010281 GTP/Mg2+ binding site [chemical binding]; other site 391037010282 G2 box; other site 391037010283 Switch I region; other site 391037010284 G3 box; other site 391037010285 Switch II region; other site 391037010286 G4 box; other site 391037010287 G5 box; other site 391037010288 Protein of unknown function (DUF742); Region: DUF742; pfam05331 391037010289 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 391037010290 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037010291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037010292 Mg2+ binding site [ion binding]; other site 391037010293 G-X-G motif; other site 391037010294 Cellulose binding domain; Region: CBM_2; pfam00553 391037010295 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 391037010296 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 391037010297 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 391037010298 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 391037010299 active site 391037010300 putative catalytic site [active] 391037010301 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 391037010302 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 391037010303 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 391037010304 active site 391037010305 Mn binding site [ion binding]; other site 391037010306 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391037010307 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 391037010308 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391037010309 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 391037010310 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391037010311 Walker A; other site 391037010312 putative acyltransferase; Provisional; Region: PRK05790 391037010313 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037010314 dimer interface [polypeptide binding]; other site 391037010315 active site 391037010316 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 391037010317 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037010318 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391037010319 dimer interface [polypeptide binding]; other site 391037010320 substrate binding site [chemical binding]; other site 391037010321 metal binding site [ion binding]; metal-binding site 391037010322 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037010323 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 391037010324 NAD(P) binding site [chemical binding]; other site 391037010325 DivIVA protein; Region: DivIVA; pfam05103 391037010326 V-type ATP synthase subunit E; Provisional; Region: PRK01558 391037010327 DivIVA protein; Region: DivIVA; pfam05103 391037010328 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391037010329 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037010330 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 391037010331 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037010332 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391037010333 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 391037010334 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037010335 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391037010336 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 391037010337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391037010338 NAD(P) binding site [chemical binding]; other site 391037010339 catalytic residues [active] 391037010340 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 391037010341 hypothetical protein; Provisional; Region: PRK03298 391037010342 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391037010343 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391037010344 B12 binding site [chemical binding]; other site 391037010345 cobalt ligand [ion binding]; other site 391037010346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037010347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037010348 Walker A/P-loop; other site 391037010349 ATP binding site [chemical binding]; other site 391037010350 Q-loop/lid; other site 391037010351 ABC transporter signature motif; other site 391037010352 Walker B; other site 391037010353 D-loop; other site 391037010354 H-loop/switch region; other site 391037010355 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037010356 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 391037010357 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037010358 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 391037010359 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391037010360 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391037010361 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391037010362 hinge; other site 391037010363 active site 391037010364 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 391037010365 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 391037010366 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 391037010367 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391037010368 gamma subunit interface [polypeptide binding]; other site 391037010369 epsilon subunit interface [polypeptide binding]; other site 391037010370 LBP interface [polypeptide binding]; other site 391037010371 Transcriptional regulator [Transcription]; Region: LytR; COG1316 391037010372 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391037010373 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391037010374 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391037010375 alpha subunit interaction interface [polypeptide binding]; other site 391037010376 Walker A motif; other site 391037010377 ATP binding site [chemical binding]; other site 391037010378 Walker B motif; other site 391037010379 inhibitor binding site; inhibition site 391037010380 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391037010381 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 391037010382 core domain interface [polypeptide binding]; other site 391037010383 delta subunit interface [polypeptide binding]; other site 391037010384 epsilon subunit interface [polypeptide binding]; other site 391037010385 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391037010386 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391037010387 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391037010388 beta subunit interaction interface [polypeptide binding]; other site 391037010389 Walker A motif; other site 391037010390 ATP binding site [chemical binding]; other site 391037010391 Walker B motif; other site 391037010392 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391037010393 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 391037010394 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 391037010395 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 391037010396 ATP synthase subunit C; Region: ATP-synt_C; cl00466 391037010397 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 391037010398 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 391037010399 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 391037010400 Transglycosylase; Region: Transgly; pfam00912 391037010401 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391037010402 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391037010403 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391037010404 active site 391037010405 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391037010406 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 391037010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037010408 S-adenosylmethionine binding site [chemical binding]; other site 391037010409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037010410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037010411 metal binding site [ion binding]; metal-binding site 391037010412 active site 391037010413 I-site; other site 391037010414 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391037010415 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391037010416 RF-1 domain; Region: RF-1; pfam00472 391037010417 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 391037010418 transcription termination factor Rho; Provisional; Region: PRK12678 391037010419 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 391037010420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391037010421 RNA binding site [nucleotide binding]; other site 391037010422 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391037010423 Walker A motif; other site 391037010424 ATP binding site [chemical binding]; other site 391037010425 Walker B motif; other site 391037010426 homoserine kinase; Provisional; Region: PRK01212 391037010427 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 391037010428 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037010429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 391037010430 putative substrate translocation pore; other site 391037010431 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391037010432 Protein export membrane protein; Region: SecD_SecF; cl14618 391037010433 threonine synthase; Reviewed; Region: PRK06721 391037010434 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 391037010435 homodimer interface [polypeptide binding]; other site 391037010436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037010437 catalytic residue [active] 391037010438 homoserine dehydrogenase; Provisional; Region: PRK06349 391037010439 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391037010440 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391037010441 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391037010442 diaminopimelate decarboxylase; Region: lysA; TIGR01048 391037010443 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391037010444 active site 391037010445 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037010446 substrate binding site [chemical binding]; other site 391037010447 catalytic residues [active] 391037010448 dimer interface [polypeptide binding]; other site 391037010449 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 391037010450 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 391037010451 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391037010452 active site 391037010453 HIGH motif; other site 391037010454 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037010455 KMSK motif region; other site 391037010456 tRNA binding surface [nucleotide binding]; other site 391037010457 DALR anticodon binding domain; Region: DALR_1; smart00836 391037010458 anticodon binding site; other site 391037010459 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 391037010460 Domain of unknown function (DUF305); Region: DUF305; pfam03713 391037010461 Winged helix-turn helix; Region: HTH_33; pfam13592 391037010462 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 391037010463 nucleotide binding site [chemical binding]; other site 391037010464 Predicted transcriptional regulators [Transcription]; Region: COG1733 391037010465 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 391037010466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037010467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037010468 MMPL family; Region: MMPL; pfam03176 391037010469 MMPL family; Region: MMPL; pfam03176 391037010470 Erythromycin esterase; Region: Erythro_esteras; pfam05139 391037010471 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 391037010472 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 391037010473 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 391037010474 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391037010475 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391037010476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037010477 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391037010478 NAD(P) binding site [chemical binding]; other site 391037010479 active site 391037010480 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 391037010481 active site 391037010482 catalytic residues [active] 391037010483 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 391037010484 metal binding site [ion binding]; metal-binding site 391037010485 ligand binding site [chemical binding]; other site 391037010486 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 391037010487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037010488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037010489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391037010490 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391037010491 Amidinotransferase; Region: Amidinotransf; pfam02274 391037010492 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 391037010493 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037010494 inhibitor-cofactor binding pocket; inhibition site 391037010495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037010496 catalytic residue [active] 391037010497 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 391037010498 phosphopeptide binding site; other site 391037010499 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 391037010500 aromatic arch; other site 391037010501 DCoH dimer interaction site [polypeptide binding]; other site 391037010502 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391037010503 DCoH tetramer interaction site [polypeptide binding]; other site 391037010504 substrate binding site [chemical binding]; other site 391037010505 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 391037010506 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391037010507 putative di-iron ligands [ion binding]; other site 391037010508 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 391037010509 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037010510 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391037010511 putative acyl-acceptor binding pocket; other site 391037010512 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 391037010513 nucleophile elbow; other site 391037010514 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 391037010515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037010516 putative ADP-binding pocket [chemical binding]; other site 391037010517 BON domain; Region: BON; pfam04972 391037010518 BON domain; Region: BON; pfam04972 391037010519 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391037010520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391037010521 protein binding site [polypeptide binding]; other site 391037010522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037010523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037010524 dimerization interface [polypeptide binding]; other site 391037010525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037010526 dimer interface [polypeptide binding]; other site 391037010527 phosphorylation site [posttranslational modification] 391037010528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037010529 ATP binding site [chemical binding]; other site 391037010530 Mg2+ binding site [ion binding]; other site 391037010531 G-X-G motif; other site 391037010532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037010533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037010534 active site 391037010535 phosphorylation site [posttranslational modification] 391037010536 intermolecular recognition site; other site 391037010537 dimerization interface [polypeptide binding]; other site 391037010538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037010539 DNA binding site [nucleotide binding] 391037010540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391037010541 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391037010542 putative acyl-acceptor binding pocket; other site 391037010543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391037010544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 391037010545 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037010546 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 391037010547 Walker A/P-loop; other site 391037010548 ATP binding site [chemical binding]; other site 391037010549 Q-loop/lid; other site 391037010550 ABC transporter signature motif; other site 391037010551 Walker B; other site 391037010552 D-loop; other site 391037010553 H-loop/switch region; other site 391037010554 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 391037010555 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 391037010556 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391037010557 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 391037010558 TPP-binding site [chemical binding]; other site 391037010559 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 391037010560 dimer interface [polypeptide binding]; other site 391037010561 PYR/PP interface [polypeptide binding]; other site 391037010562 TPP binding site [chemical binding]; other site 391037010563 phosphate acetyltransferase; Reviewed; Region: PRK05632 391037010564 DRTGG domain; Region: DRTGG; pfam07085 391037010565 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 391037010566 Acetokinase family; Region: Acetate_kinase; cl17229 391037010567 propionate/acetate kinase; Provisional; Region: PRK12379 391037010568 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037010569 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037010570 NAD(P) binding site [chemical binding]; other site 391037010571 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 391037010572 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391037010573 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 391037010574 NAD(P) binding pocket [chemical binding]; other site 391037010575 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 391037010576 Catalytic site [active] 391037010577 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 391037010578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391037010579 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 391037010580 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 391037010581 Transcription factor WhiB; Region: Whib; pfam02467 391037010582 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391037010583 putative active site [active] 391037010584 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 391037010585 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391037010586 Active Sites [active] 391037010587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 391037010588 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391037010589 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391037010590 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391037010591 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 391037010592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391037010593 Histidine kinase; Region: HisKA_2; pfam07568 391037010594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037010595 ATP binding site [chemical binding]; other site 391037010596 Mg2+ binding site [ion binding]; other site 391037010597 G-X-G motif; other site 391037010598 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391037010599 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391037010600 dimer interface [polypeptide binding]; other site 391037010601 active site 391037010602 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391037010603 dimer interface [polypeptide binding]; other site 391037010604 active site 391037010605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037010606 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391037010607 TPR motif; other site 391037010608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037010609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037010610 putative substrate translocation pore; other site 391037010611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037010612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037010613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037010614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037010615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037010616 Coenzyme A binding pocket [chemical binding]; other site 391037010617 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391037010618 carboxyltransferase (CT) interaction site; other site 391037010619 biotinylation site [posttranslational modification]; other site 391037010620 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 391037010621 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 391037010622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037010623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037010624 DNA binding residues [nucleotide binding] 391037010625 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 391037010626 Transcription factor WhiB; Region: Whib; pfam02467 391037010627 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 391037010628 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391037010629 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391037010630 hinge; other site 391037010631 active site 391037010632 Predicted GTPases [General function prediction only]; Region: COG1162 391037010633 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 391037010634 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391037010635 GTP/Mg2+ binding site [chemical binding]; other site 391037010636 G4 box; other site 391037010637 G5 box; other site 391037010638 G1 box; other site 391037010639 Switch I region; other site 391037010640 G2 box; other site 391037010641 G3 box; other site 391037010642 Switch II region; other site 391037010643 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391037010644 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391037010645 active site 391037010646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037010647 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 391037010648 putative ADP-binding pocket [chemical binding]; other site 391037010649 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391037010650 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 391037010651 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 391037010652 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391037010653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037010654 active site 391037010655 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 391037010656 ATP binding site [chemical binding]; other site 391037010657 active site 391037010658 substrate binding site [chemical binding]; other site 391037010659 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 391037010660 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 391037010661 hypothetical protein; Validated; Region: PRK00068 391037010662 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 391037010663 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 391037010664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391037010665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391037010666 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 391037010667 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 391037010668 Protein of unknown function DUF45; Region: DUF45; pfam01863 391037010669 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 391037010670 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 391037010671 ATP binding site [chemical binding]; other site 391037010672 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391037010673 ABC1 family; Region: ABC1; pfam03109 391037010674 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 391037010675 active site 391037010676 ATP binding site [chemical binding]; other site 391037010677 Transcription factor WhiB; Region: Whib; pfam02467 391037010678 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 391037010679 Part of AAA domain; Region: AAA_19; pfam13245 391037010680 Family description; Region: UvrD_C_2; pfam13538 391037010681 HRDC domain; Region: HRDC; pfam00570 391037010682 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 391037010683 catalytic residues [active] 391037010684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037010685 putative substrate translocation pore; other site 391037010686 Helix-turn-helix domain; Region: HTH_31; pfam13560 391037010687 sequence-specific DNA binding site [nucleotide binding]; other site 391037010688 salt bridge; other site 391037010689 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037010690 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 391037010691 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 391037010692 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391037010693 putative NADH binding site [chemical binding]; other site 391037010694 putative active site [active] 391037010695 nudix motif; other site 391037010696 putative metal binding site [ion binding]; other site 391037010697 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391037010698 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391037010699 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391037010700 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391037010701 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391037010702 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391037010703 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391037010704 Part of AAA domain; Region: AAA_19; pfam13245 391037010705 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391037010706 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391037010707 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391037010708 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 391037010709 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 391037010710 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 391037010711 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 391037010712 metal binding site [ion binding]; metal-binding site 391037010713 putative dimer interface [polypeptide binding]; other site 391037010714 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 391037010715 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 391037010716 putative trimer interface [polypeptide binding]; other site 391037010717 putative CoA binding site [chemical binding]; other site 391037010718 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037010719 active site 391037010720 catalytic residues [active] 391037010721 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 391037010722 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391037010723 active site 391037010724 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 391037010725 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 391037010726 prephenate dehydrogenase; Validated; Region: PRK08507 391037010727 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 391037010728 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037010729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037010730 homodimer interface [polypeptide binding]; other site 391037010731 catalytic residue [active] 391037010732 Ferredoxin [Energy production and conversion]; Region: COG1146 391037010733 4Fe-4S binding domain; Region: Fer4; pfam00037 391037010734 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037010735 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 391037010736 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 391037010737 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 391037010738 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037010739 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391037010740 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 391037010741 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 391037010742 L-aspartate oxidase; Provisional; Region: PRK06175 391037010743 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391037010744 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 391037010745 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037010746 catalytic loop [active] 391037010747 iron binding site [ion binding]; other site 391037010748 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391037010749 active site 391037010750 8-oxo-dGMP binding site [chemical binding]; other site 391037010751 nudix motif; other site 391037010752 metal binding site [ion binding]; metal-binding site 391037010753 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 391037010754 Pleckstrin homology-like domain; Region: PH-like; cl17171 391037010755 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391037010756 active site 391037010757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391037010758 sequence-specific DNA binding site [nucleotide binding]; other site 391037010759 salt bridge; other site 391037010760 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 391037010761 Active_site [active] 391037010762 Predicted membrane protein [Function unknown]; Region: COG2311 391037010763 Protein of unknown function (DUF418); Region: DUF418; cl12135 391037010764 Protein of unknown function (DUF418); Region: DUF418; pfam04235 391037010765 GTP-binding protein YchF; Reviewed; Region: PRK09601 391037010766 YchF GTPase; Region: YchF; cd01900 391037010767 G1 box; other site 391037010768 GTP/Mg2+ binding site [chemical binding]; other site 391037010769 Switch I region; other site 391037010770 G2 box; other site 391037010771 Switch II region; other site 391037010772 G3 box; other site 391037010773 G4 box; other site 391037010774 G5 box; other site 391037010775 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391037010776 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 391037010777 active site pocket [active] 391037010778 oxyanion hole [active] 391037010779 catalytic triad [active] 391037010780 active site nucleophile [active] 391037010781 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 391037010782 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 391037010783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037010784 AlkA N-terminal domain; Region: AlkA_N; pfam06029 391037010785 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 391037010786 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391037010787 minor groove reading motif; other site 391037010788 helix-hairpin-helix signature motif; other site 391037010789 substrate binding pocket [chemical binding]; other site 391037010790 active site 391037010791 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391037010792 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391037010793 active site 391037010794 DNA binding site [nucleotide binding] 391037010795 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391037010796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037010797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037010798 Walker A/P-loop; other site 391037010799 ATP binding site [chemical binding]; other site 391037010800 Q-loop/lid; other site 391037010801 ABC transporter signature motif; other site 391037010802 Walker B; other site 391037010803 D-loop; other site 391037010804 H-loop/switch region; other site 391037010805 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391037010806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391037010807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037010808 Walker A/P-loop; other site 391037010809 ATP binding site [chemical binding]; other site 391037010810 Q-loop/lid; other site 391037010811 ABC transporter signature motif; other site 391037010812 Walker B; other site 391037010813 D-loop; other site 391037010814 H-loop/switch region; other site 391037010815 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391037010816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037010817 Walker A/P-loop; other site 391037010818 ATP binding site [chemical binding]; other site 391037010819 Q-loop/lid; other site 391037010820 ABC transporter signature motif; other site 391037010821 Walker B; other site 391037010822 D-loop; other site 391037010823 H-loop/switch region; other site 391037010824 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 391037010825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037010826 Walker A/P-loop; other site 391037010827 ATP binding site [chemical binding]; other site 391037010828 Q-loop/lid; other site 391037010829 ABC transporter signature motif; other site 391037010830 Walker B; other site 391037010831 D-loop; other site 391037010832 H-loop/switch region; other site 391037010833 Electron transfer DM13; Region: DM13; pfam10517 391037010834 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 391037010835 PUA-like domain; Region: PUA_2; pfam14306 391037010836 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 391037010837 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 391037010838 ligand-binding site [chemical binding]; other site 391037010839 isocitrate dehydrogenase; Validated; Region: PRK08299 391037010840 malate dehydrogenase; Reviewed; Region: PRK06223 391037010841 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 391037010842 NAD(P) binding site [chemical binding]; other site 391037010843 dimer interface [polypeptide binding]; other site 391037010844 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391037010845 substrate binding site [chemical binding]; other site 391037010846 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 391037010847 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391037010848 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391037010849 homodimer interface [polypeptide binding]; other site 391037010850 NADP binding site [chemical binding]; other site 391037010851 substrate binding site [chemical binding]; other site 391037010852 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391037010853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 391037010854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037010855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010856 dimer interface [polypeptide binding]; other site 391037010857 conserved gate region; other site 391037010858 putative PBP binding loops; other site 391037010859 ABC-ATPase subunit interface; other site 391037010860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391037010861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010862 dimer interface [polypeptide binding]; other site 391037010863 conserved gate region; other site 391037010864 putative PBP binding loops; other site 391037010865 ABC-ATPase subunit interface; other site 391037010866 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391037010867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037010868 Walker A/P-loop; other site 391037010869 ATP binding site [chemical binding]; other site 391037010870 Q-loop/lid; other site 391037010871 ABC transporter signature motif; other site 391037010872 Walker B; other site 391037010873 D-loop; other site 391037010874 H-loop/switch region; other site 391037010875 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391037010876 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391037010877 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037010878 Walker A/P-loop; other site 391037010879 ATP binding site [chemical binding]; other site 391037010880 Q-loop/lid; other site 391037010881 ABC transporter signature motif; other site 391037010882 Walker B; other site 391037010883 D-loop; other site 391037010884 H-loop/switch region; other site 391037010885 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391037010886 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 391037010887 Catalytic site [active] 391037010888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037010889 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037010890 Walker A/P-loop; other site 391037010891 ATP binding site [chemical binding]; other site 391037010892 Q-loop/lid; other site 391037010893 ABC transporter signature motif; other site 391037010894 Walker B; other site 391037010895 D-loop; other site 391037010896 H-loop/switch region; other site 391037010897 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391037010898 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 391037010899 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037010900 AAA ATPase domain; Region: AAA_16; pfam13191 391037010901 Walker A motif; other site 391037010902 ATP binding site [chemical binding]; other site 391037010903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391037010904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391037010905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037010906 putative DNA binding site [nucleotide binding]; other site 391037010907 putative Zn2+ binding site [ion binding]; other site 391037010908 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391037010909 classical (c) SDRs; Region: SDR_c; cd05233 391037010910 NAD(P) binding site [chemical binding]; other site 391037010911 active site 391037010912 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391037010913 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391037010914 purine monophosphate binding site [chemical binding]; other site 391037010915 dimer interface [polypeptide binding]; other site 391037010916 putative catalytic residues [active] 391037010917 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 391037010918 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 391037010919 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391037010920 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391037010921 active site 391037010922 substrate binding site [chemical binding]; other site 391037010923 cosubstrate binding site; other site 391037010924 catalytic site [active] 391037010925 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391037010926 CoA binding domain; Region: CoA_binding; smart00881 391037010927 CoA-ligase; Region: Ligase_CoA; pfam00549 391037010928 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391037010929 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391037010930 CoA-ligase; Region: Ligase_CoA; pfam00549 391037010931 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391037010932 B12 binding site [chemical binding]; other site 391037010933 cobalt ligand [ion binding]; other site 391037010934 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391037010935 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037010936 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391037010937 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037010938 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 391037010939 Part of AAA domain; Region: AAA_19; pfam13245 391037010940 Family description; Region: UvrD_C_2; pfam13538 391037010941 Chorismate mutase type II; Region: CM_2; cl00693 391037010942 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391037010943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037010944 Walker A/P-loop; other site 391037010945 ATP binding site [chemical binding]; other site 391037010946 Q-loop/lid; other site 391037010947 ABC transporter signature motif; other site 391037010948 Walker B; other site 391037010949 D-loop; other site 391037010950 H-loop/switch region; other site 391037010951 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391037010952 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391037010953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037010954 Walker A/P-loop; other site 391037010955 ATP binding site [chemical binding]; other site 391037010956 Q-loop/lid; other site 391037010957 ABC transporter signature motif; other site 391037010958 Walker B; other site 391037010959 D-loop; other site 391037010960 H-loop/switch region; other site 391037010961 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391037010962 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391037010963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010964 dimer interface [polypeptide binding]; other site 391037010965 conserved gate region; other site 391037010966 putative PBP binding loops; other site 391037010967 ABC-ATPase subunit interface; other site 391037010968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037010969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037010970 conserved gate region; other site 391037010971 putative PBP binding loops; other site 391037010972 ABC-ATPase subunit interface; other site 391037010973 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 391037010974 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391037010975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037010976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037010977 active site 391037010978 phosphorylation site [posttranslational modification] 391037010979 intermolecular recognition site; other site 391037010980 dimerization interface [polypeptide binding]; other site 391037010981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037010982 DNA binding residues [nucleotide binding] 391037010983 dimerization interface [polypeptide binding]; other site 391037010984 PspC domain; Region: PspC; pfam04024 391037010985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 391037010986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037010987 ATP binding site [chemical binding]; other site 391037010988 G-X-G motif; other site 391037010989 PspC domain; Region: PspC; pfam04024 391037010990 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 391037010991 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 391037010992 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391037010993 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391037010994 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391037010995 nudix motif; other site 391037010996 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037010997 nudix motif; other site 391037010998 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037010999 nudix motif; other site 391037011000 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 391037011001 nudix motif; other site 391037011002 PspC domain; Region: PspC; pfam04024 391037011003 GMP synthase; Reviewed; Region: guaA; PRK00074 391037011004 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391037011005 AMP/PPi binding site [chemical binding]; other site 391037011006 candidate oxyanion hole; other site 391037011007 catalytic triad [active] 391037011008 potential glutamine specificity residues [chemical binding]; other site 391037011009 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391037011010 ATP Binding subdomain [chemical binding]; other site 391037011011 Ligand Binding sites [chemical binding]; other site 391037011012 Dimerization subdomain; other site 391037011013 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391037011014 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391037011015 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 391037011016 Peptidase family M1; Region: Peptidase_M1; pfam01433 391037011017 Zn binding site [ion binding]; other site 391037011018 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 391037011019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391037011020 phosphate binding site [ion binding]; other site 391037011021 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391037011022 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391037011023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 391037011024 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391037011025 active site 391037011026 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037011027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037011028 DNA binding residues [nucleotide binding] 391037011029 dimerization interface [polypeptide binding]; other site 391037011030 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 391037011031 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 391037011032 Moco binding site; other site 391037011033 metal coordination site [ion binding]; other site 391037011034 dimerization interface [polypeptide binding]; other site 391037011035 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391037011036 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391037011037 ring oligomerisation interface [polypeptide binding]; other site 391037011038 ATP/Mg binding site [chemical binding]; other site 391037011039 stacking interactions; other site 391037011040 hinge regions; other site 391037011041 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391037011042 oligomerisation interface [polypeptide binding]; other site 391037011043 mobile loop; other site 391037011044 roof hairpin; other site 391037011045 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 391037011046 putative deacylase active site [active] 391037011047 FtsJ-like methyltransferase; Region: FtsJ; cl17430 391037011048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037011049 S-adenosylmethionine binding site [chemical binding]; other site 391037011050 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391037011051 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391037011052 putative ligand binding site [chemical binding]; other site 391037011053 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391037011054 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391037011055 Walker A/P-loop; other site 391037011056 ATP binding site [chemical binding]; other site 391037011057 Q-loop/lid; other site 391037011058 ABC transporter signature motif; other site 391037011059 Walker B; other site 391037011060 D-loop; other site 391037011061 H-loop/switch region; other site 391037011062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037011063 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391037011064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391037011065 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391037011066 TM-ABC transporter signature motif; other site 391037011067 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037011068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391037011069 UGMP family protein; Validated; Region: PRK09604 391037011070 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 391037011071 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 391037011072 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391037011073 Glycoprotease family; Region: Peptidase_M22; pfam00814 391037011074 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 391037011075 ligand binding site [chemical binding]; other site 391037011076 active site 391037011077 UGI interface [polypeptide binding]; other site 391037011078 catalytic site [active] 391037011079 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 391037011080 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037011081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037011082 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391037011083 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 391037011084 alanine racemase; Reviewed; Region: alr; PRK00053 391037011085 active site 391037011086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037011087 dimer interface [polypeptide binding]; other site 391037011088 substrate binding site [chemical binding]; other site 391037011089 catalytic residues [active] 391037011090 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 391037011091 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 391037011092 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391037011093 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 391037011094 glutaminase active site [active] 391037011095 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391037011096 dimer interface [polypeptide binding]; other site 391037011097 active site 391037011098 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391037011099 dimer interface [polypeptide binding]; other site 391037011100 active site 391037011101 aminotransferase; Validated; Region: PRK07777 391037011102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037011103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037011104 homodimer interface [polypeptide binding]; other site 391037011105 catalytic residue [active] 391037011106 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 391037011107 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 391037011108 active site 391037011109 substrate binding site [chemical binding]; other site 391037011110 metal binding site [ion binding]; metal-binding site 391037011111 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 391037011112 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391037011113 23S rRNA interface [nucleotide binding]; other site 391037011114 L3 interface [polypeptide binding]; other site 391037011115 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 391037011116 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 391037011117 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 391037011118 [4Fe-4S] binding site [ion binding]; other site 391037011119 molybdopterin cofactor binding site; other site 391037011120 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 391037011121 molybdopterin cofactor binding site; other site 391037011122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391037011123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037011124 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391037011125 nitrite reductase subunit NirD; Provisional; Region: PRK14989 391037011126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037011127 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391037011128 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391037011129 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 391037011130 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 391037011131 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391037011132 active site 391037011133 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 391037011134 DNA binding site [nucleotide binding] 391037011135 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 391037011136 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 391037011137 G1 box; other site 391037011138 GTP/Mg2+ binding site [chemical binding]; other site 391037011139 G2 box; other site 391037011140 Switch I region; other site 391037011141 G3 box; other site 391037011142 Switch II region; other site 391037011143 G4 box; other site 391037011144 G5 box; other site 391037011145 Protein of unknown function (DUF742); Region: DUF742; pfam05331 391037011146 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 391037011147 Nitrate and nitrite sensing; Region: NIT; pfam08376 391037011148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037011149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037011150 ATP binding site [chemical binding]; other site 391037011151 Mg2+ binding site [ion binding]; other site 391037011152 G-X-G motif; other site 391037011153 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 391037011154 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391037011155 putative ligand binding site [chemical binding]; other site 391037011156 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391037011157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037011158 dimer interface [polypeptide binding]; other site 391037011159 conserved gate region; other site 391037011160 putative PBP binding loops; other site 391037011161 ABC-ATPase subunit interface; other site 391037011162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391037011163 NMT1/THI5 like; Region: NMT1; pfam09084 391037011164 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391037011165 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391037011166 Walker A/P-loop; other site 391037011167 ATP binding site [chemical binding]; other site 391037011168 Q-loop/lid; other site 391037011169 ABC transporter signature motif; other site 391037011170 Walker B; other site 391037011171 D-loop; other site 391037011172 H-loop/switch region; other site 391037011173 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 391037011174 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391037011175 Cupin domain; Region: Cupin_2; cl17218 391037011176 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 391037011177 ThiC-associated domain; Region: ThiC-associated; pfam13667 391037011178 ThiC family; Region: ThiC; pfam01964 391037011179 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391037011180 dimer interface [polypeptide binding]; other site 391037011181 substrate binding site [chemical binding]; other site 391037011182 ATP binding site [chemical binding]; other site 391037011183 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391037011184 thiamine phosphate binding site [chemical binding]; other site 391037011185 active site 391037011186 pyrophosphate binding site [ion binding]; other site 391037011187 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391037011188 ThiS interaction site; other site 391037011189 putative active site [active] 391037011190 tetramer interface [polypeptide binding]; other site 391037011191 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391037011192 thiS-thiF/thiG interaction site; other site 391037011193 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391037011194 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391037011195 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391037011196 thiamine phosphate binding site [chemical binding]; other site 391037011197 active site 391037011198 pyrophosphate binding site [ion binding]; other site 391037011199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391037011200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391037011201 active site 391037011202 catalytic tetrad [active] 391037011203 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391037011204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037011205 Walker A/P-loop; other site 391037011206 ATP binding site [chemical binding]; other site 391037011207 Q-loop/lid; other site 391037011208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037011209 ABC transporter signature motif; other site 391037011210 Walker B; other site 391037011211 D-loop; other site 391037011212 H-loop/switch region; other site 391037011213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391037011214 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 391037011215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037011216 S-adenosylmethionine binding site [chemical binding]; other site 391037011217 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391037011218 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 391037011219 dimerization interface 3.5A [polypeptide binding]; other site 391037011220 active site 391037011221 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 391037011222 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391037011223 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391037011224 alphaNTD homodimer interface [polypeptide binding]; other site 391037011225 alphaNTD - beta interaction site [polypeptide binding]; other site 391037011226 alphaNTD - beta' interaction site [polypeptide binding]; other site 391037011227 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 391037011228 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391037011229 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391037011230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037011231 RNA binding surface [nucleotide binding]; other site 391037011232 30S ribosomal protein S11; Validated; Region: PRK05309 391037011233 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 391037011234 30S ribosomal protein S13; Region: bact_S13; TIGR03631 391037011235 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 391037011236 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391037011237 rRNA binding site [nucleotide binding]; other site 391037011238 predicted 30S ribosome binding site; other site 391037011239 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 391037011240 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391037011241 active site 391037011242 adenylate kinase; Reviewed; Region: adk; PRK00279 391037011243 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391037011244 AMP-binding site [chemical binding]; other site 391037011245 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391037011246 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391037011247 SecY translocase; Region: SecY; pfam00344 391037011248 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 391037011249 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 391037011250 23S rRNA binding site [nucleotide binding]; other site 391037011251 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391037011252 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391037011253 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391037011254 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391037011255 23S rRNA interface [nucleotide binding]; other site 391037011256 5S rRNA interface [nucleotide binding]; other site 391037011257 L27 interface [polypeptide binding]; other site 391037011258 L5 interface [polypeptide binding]; other site 391037011259 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391037011260 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391037011261 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391037011262 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 391037011263 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 391037011264 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391037011265 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391037011266 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391037011267 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 391037011268 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 391037011269 RNA binding site [nucleotide binding]; other site 391037011270 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 391037011271 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 391037011272 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 391037011273 putative translocon interaction site; other site 391037011274 signal recognition particle (SRP54) interaction site; other site 391037011275 L23 interface [polypeptide binding]; other site 391037011276 trigger factor interaction site; other site 391037011277 23S rRNA interface [nucleotide binding]; other site 391037011278 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391037011279 23S rRNA interface [nucleotide binding]; other site 391037011280 5S rRNA interface [nucleotide binding]; other site 391037011281 putative antibiotic binding site [chemical binding]; other site 391037011282 L25 interface [polypeptide binding]; other site 391037011283 L27 interface [polypeptide binding]; other site 391037011284 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391037011285 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 391037011286 G-X-X-G motif; other site 391037011287 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391037011288 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391037011289 putative translocon binding site; other site 391037011290 protein-rRNA interface [nucleotide binding]; other site 391037011291 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 391037011292 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391037011293 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391037011294 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391037011295 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 391037011296 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 391037011297 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 391037011298 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 391037011299 elongation factor Tu; Reviewed; Region: PRK00049 391037011300 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391037011301 G1 box; other site 391037011302 GEF interaction site [polypeptide binding]; other site 391037011303 GTP/Mg2+ binding site [chemical binding]; other site 391037011304 Switch I region; other site 391037011305 G2 box; other site 391037011306 G3 box; other site 391037011307 Switch II region; other site 391037011308 G4 box; other site 391037011309 G5 box; other site 391037011310 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391037011311 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391037011312 Antibiotic Binding Site [chemical binding]; other site 391037011313 elongation factor G; Reviewed; Region: PRK00007 391037011314 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 391037011315 G1 box; other site 391037011316 putative GEF interaction site [polypeptide binding]; other site 391037011317 GTP/Mg2+ binding site [chemical binding]; other site 391037011318 Switch I region; other site 391037011319 G2 box; other site 391037011320 G3 box; other site 391037011321 Switch II region; other site 391037011322 G4 box; other site 391037011323 G5 box; other site 391037011324 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391037011325 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391037011326 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391037011327 30S ribosomal protein S7; Validated; Region: PRK05302 391037011328 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391037011329 S17 interaction site [polypeptide binding]; other site 391037011330 S8 interaction site; other site 391037011331 16S rRNA interaction site [nucleotide binding]; other site 391037011332 streptomycin interaction site [chemical binding]; other site 391037011333 23S rRNA interaction site [nucleotide binding]; other site 391037011334 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391037011335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037011336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037011337 active site 391037011338 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391037011339 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 391037011340 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391037011341 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391037011342 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 391037011343 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391037011344 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 391037011345 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391037011346 G-loop; other site 391037011347 DNA binding site [nucleotide binding] 391037011348 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 391037011349 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391037011350 RPB12 interaction site [polypeptide binding]; other site 391037011351 RPB1 interaction site [polypeptide binding]; other site 391037011352 RPB10 interaction site [polypeptide binding]; other site 391037011353 RPB11 interaction site [polypeptide binding]; other site 391037011354 RPB3 interaction site [polypeptide binding]; other site 391037011355 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391037011356 core dimer interface [polypeptide binding]; other site 391037011357 peripheral dimer interface [polypeptide binding]; other site 391037011358 L10 interface [polypeptide binding]; other site 391037011359 L11 interface [polypeptide binding]; other site 391037011360 putative EF-Tu interaction site [polypeptide binding]; other site 391037011361 putative EF-G interaction site [polypeptide binding]; other site 391037011362 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 391037011363 23S rRNA interface [nucleotide binding]; other site 391037011364 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391037011365 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 391037011366 mRNA/rRNA interface [nucleotide binding]; other site 391037011367 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391037011368 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391037011369 23S rRNA interface [nucleotide binding]; other site 391037011370 L7/L12 interface [polypeptide binding]; other site 391037011371 putative thiostrepton binding site; other site 391037011372 L25 interface [polypeptide binding]; other site 391037011373 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391037011374 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391037011375 putative homodimer interface [polypeptide binding]; other site 391037011376 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 391037011377 heterodimer interface [polypeptide binding]; other site 391037011378 homodimer interface [polypeptide binding]; other site 391037011379 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 391037011380 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391037011381 active site 2 [active] 391037011382 active site 1 [active] 391037011383 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391037011384 active site 391037011385 catalytic site [active] 391037011386 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 391037011387 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391037011388 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 391037011389 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391037011390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037011391 metal binding site [ion binding]; metal-binding site 391037011392 active site 391037011393 I-site; other site 391037011394 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037011395 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 391037011396 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391037011397 DNA-binding site [nucleotide binding]; DNA binding site 391037011398 RNA-binding motif; other site 391037011399 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 391037011400 WYL domain; Region: WYL; pfam13280 391037011401 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 391037011402 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 391037011403 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 391037011404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037011405 ATP binding site [chemical binding]; other site 391037011406 putative Mg++ binding site [ion binding]; other site 391037011407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037011408 nucleotide binding region [chemical binding]; other site 391037011409 ATP-binding site [chemical binding]; other site 391037011410 Double zinc ribbon; Region: DZR; pfam12773 391037011411 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 391037011412 Peptidase family M48; Region: Peptidase_M48; cl12018 391037011413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037011414 DNA-binding site [nucleotide binding]; DNA binding site 391037011415 DivIVA domain; Region: DivI1A_domain; TIGR03544 391037011416 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 391037011417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037011418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037011419 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 391037011420 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 391037011421 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391037011422 active site 391037011423 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 391037011424 nucleotide binding site [chemical binding]; other site 391037011425 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 391037011426 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 391037011427 active site 391037011428 DNA binding site [nucleotide binding] 391037011429 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 391037011430 DNA binding site [nucleotide binding] 391037011431 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 391037011432 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 391037011433 putative DNA binding site [nucleotide binding]; other site 391037011434 putative homodimer interface [polypeptide binding]; other site 391037011435 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391037011436 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 391037011437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391037011438 motif I; other site 391037011439 active site 391037011440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037011441 motif II; other site 391037011442 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391037011443 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 391037011444 NAD(P) binding site [chemical binding]; other site 391037011445 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 391037011446 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 391037011447 dimer interface [polypeptide binding]; other site 391037011448 acyl-activating enzyme (AAE) consensus motif; other site 391037011449 putative active site [active] 391037011450 AMP binding site [chemical binding]; other site 391037011451 putative CoA binding site [chemical binding]; other site 391037011452 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391037011453 nudix motif; other site 391037011454 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391037011455 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 391037011456 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391037011457 active site 391037011458 nucleotide binding site [chemical binding]; other site 391037011459 HIGH motif; other site 391037011460 KMSKS motif; other site 391037011461 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391037011462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391037011463 active site 391037011464 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 391037011465 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 391037011466 putative active site [active] 391037011467 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391037011468 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 391037011469 putative dimer interface [polypeptide binding]; other site 391037011470 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 391037011471 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 391037011472 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 391037011473 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037011474 active site 391037011475 OsmC-like protein; Region: OsmC; cl00767 391037011476 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391037011477 Beta-lactamase; Region: Beta-lactamase; pfam00144 391037011478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037011479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391037011480 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 391037011481 HTH domain; Region: HTH_11; pfam08279 391037011482 WYL domain; Region: WYL; pfam13280 391037011483 Epoxide hydrolase N terminus; Region: EHN; pfam06441 391037011484 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037011485 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 391037011486 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011487 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011488 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011489 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037011490 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011491 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011492 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011493 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391037011494 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 391037011495 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011496 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011497 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011498 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037011499 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011500 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011501 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011502 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037011504 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 391037011507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011508 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037011509 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 391037011510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 391037011511 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 391037011512 Methyltransferase domain; Region: Methyltransf_18; pfam12847 391037011513 S-adenosylmethionine binding site [chemical binding]; other site 391037011514 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391037011515 PSP1 C-terminal conserved region; Region: PSP1; cl00770 391037011516 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 391037011517 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391037011518 DNA polymerase III subunit delta'; Validated; Region: PRK08485 391037011519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037011520 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037011521 thymidylate kinase; Validated; Region: tmk; PRK00698 391037011522 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 391037011523 TMP-binding site; other site 391037011524 ATP-binding site [chemical binding]; other site 391037011525 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 391037011526 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391037011527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391037011528 catalytic residue [active] 391037011529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037011530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037011531 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 391037011532 FAD binding domain; Region: FAD_binding_4; pfam01565 391037011533 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 391037011534 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 391037011535 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 391037011536 active site 391037011537 interdomain interaction site; other site 391037011538 putative metal-binding site [ion binding]; other site 391037011539 nucleotide binding site [chemical binding]; other site 391037011540 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 391037011541 domain I; other site 391037011542 phosphate binding site [ion binding]; other site 391037011543 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 391037011544 domain II; other site 391037011545 domain III; other site 391037011546 nucleotide binding site [chemical binding]; other site 391037011547 DNA binding groove [nucleotide binding] 391037011548 catalytic site [active] 391037011549 domain IV; other site 391037011550 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391037011551 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391037011552 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391037011553 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 391037011554 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 391037011555 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391037011556 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037011557 anti sigma factor interaction site; other site 391037011558 regulatory phosphorylation site [posttranslational modification]; other site 391037011559 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 391037011560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391037011561 ATP binding site [chemical binding]; other site 391037011562 putative Mg++ binding site [ion binding]; other site 391037011563 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 391037011564 Tubby C 2; Region: Tub_2; cl02043 391037011565 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 391037011566 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 391037011567 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391037011568 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 391037011569 ATP binding site [chemical binding]; other site 391037011570 Walker B motif; other site 391037011571 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 391037011572 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 391037011573 nucleotide binding site/active site [active] 391037011574 HIT family signature motif; other site 391037011575 catalytic residue [active] 391037011576 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391037011577 oligomeric interface; other site 391037011578 putative active site [active] 391037011579 homodimer interface [polypeptide binding]; other site 391037011580 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391037011581 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391037011582 acetyl-CoA synthetase; Provisional; Region: PRK00174 391037011583 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391037011584 active site 391037011585 CoA binding site [chemical binding]; other site 391037011586 acyl-activating enzyme (AAE) consensus motif; other site 391037011587 AMP binding site [chemical binding]; other site 391037011588 acetate binding site [chemical binding]; other site 391037011589 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 391037011590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037011591 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037011592 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037011593 active site 391037011594 catalytic residues [active] 391037011595 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 391037011596 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 391037011597 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 391037011598 Membrane protein of unknown function; Region: DUF360; pfam04020 391037011599 Putative zinc-finger; Region: zf-HC2; pfam13490 391037011600 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 391037011601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037011602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037011603 DNA binding residues [nucleotide binding] 391037011604 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 391037011605 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 391037011606 Bacterial transcriptional regulator; Region: IclR; pfam01614 391037011607 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391037011608 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391037011609 substrate binding pocket [chemical binding]; other site 391037011610 chain length determination region; other site 391037011611 substrate-Mg2+ binding site; other site 391037011612 catalytic residues [active] 391037011613 aspartate-rich region 1; other site 391037011614 active site lid residues [active] 391037011615 aspartate-rich region 2; other site 391037011616 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391037011617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037011618 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391037011619 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037011620 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 391037011621 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391037011622 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391037011623 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 391037011624 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391037011625 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391037011626 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391037011627 4Fe-4S binding domain; Region: Fer4; pfam00037 391037011628 4Fe-4S binding domain; Region: Fer4; pfam00037 391037011629 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391037011630 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 391037011631 NADH dehydrogenase subunit G; Validated; Region: PRK07860 391037011632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037011633 catalytic loop [active] 391037011634 iron binding site [ion binding]; other site 391037011635 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391037011636 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391037011637 molybdopterin cofactor binding site; other site 391037011638 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 391037011639 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 391037011640 SLBB domain; Region: SLBB; pfam10531 391037011641 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 391037011642 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 391037011643 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 391037011644 putative dimer interface [polypeptide binding]; other site 391037011645 [2Fe-2S] cluster binding site [ion binding]; other site 391037011646 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 391037011647 NADH dehydrogenase subunit D; Validated; Region: PRK06075 391037011648 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 391037011649 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 391037011650 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391037011651 NADH dehydrogenase subunit A; Validated; Region: PRK07928 391037011652 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 391037011653 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 391037011654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037011655 S-adenosylmethionine binding site [chemical binding]; other site 391037011656 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 391037011657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 391037011658 FeS/SAM binding site; other site 391037011659 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 391037011660 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 391037011661 FAD binding pocket [chemical binding]; other site 391037011662 FAD binding motif [chemical binding]; other site 391037011663 phosphate binding motif [ion binding]; other site 391037011664 beta-alpha-beta structure motif; other site 391037011665 NAD(p) ribose binding residues [chemical binding]; other site 391037011666 NAD binding pocket [chemical binding]; other site 391037011667 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 391037011668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037011669 catalytic loop [active] 391037011670 iron binding site [ion binding]; other site 391037011671 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 391037011672 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 391037011673 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 391037011674 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 391037011675 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 391037011676 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 391037011677 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391037011678 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391037011679 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 391037011680 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cd09738 391037011681 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cd09734 391037011682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037011683 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037011684 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 391037011685 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037011686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037011687 motif II; other site 391037011688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037011689 salt bridge; other site 391037011690 non-specific DNA binding site [nucleotide binding]; other site 391037011691 sequence-specific DNA binding site [nucleotide binding]; other site 391037011692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391037011693 Cupin domain; Region: Cupin_2; cl17218 391037011694 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037011695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391037011696 classical (c) SDRs; Region: SDR_c; cd05233 391037011697 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 391037011698 NAD(P) binding site [chemical binding]; other site 391037011699 active site 391037011700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037011701 active site 391037011702 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 391037011703 glycyl-tRNA synthetase; Provisional; Region: PRK14908 391037011704 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 391037011705 motif 1; other site 391037011706 dimer interface [polypeptide binding]; other site 391037011707 active site 391037011708 motif 2; other site 391037011709 motif 3; other site 391037011710 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391037011711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037011712 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391037011713 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391037011714 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391037011715 Walker A/P-loop; other site 391037011716 ATP binding site [chemical binding]; other site 391037011717 Q-loop/lid; other site 391037011718 ABC transporter signature motif; other site 391037011719 Walker B; other site 391037011720 D-loop; other site 391037011721 H-loop/switch region; other site 391037011722 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 391037011723 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391037011724 ABC-ATPase subunit interface; other site 391037011725 dimer interface [polypeptide binding]; other site 391037011726 putative PBP binding regions; other site 391037011727 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 391037011728 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 391037011729 putative binding site residues; other site 391037011730 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 391037011731 putative active site [active] 391037011732 Zn binding site [ion binding]; other site 391037011733 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 391037011734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037011735 FeS/SAM binding site; other site 391037011736 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391037011737 NlpC/P60 family; Region: NLPC_P60; pfam00877 391037011738 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391037011739 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391037011740 ATP binding site [chemical binding]; other site 391037011741 Mg++ binding site [ion binding]; other site 391037011742 motif III; other site 391037011743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037011744 nucleotide binding region [chemical binding]; other site 391037011745 ATP-binding site [chemical binding]; other site 391037011746 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391037011747 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391037011748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037011749 catalytic residue [active] 391037011750 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037011751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037011752 putative DNA binding site [nucleotide binding]; other site 391037011753 putative Zn2+ binding site [ion binding]; other site 391037011754 AsnC family; Region: AsnC_trans_reg; pfam01037 391037011755 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 391037011756 DNA binding residues [nucleotide binding] 391037011757 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 391037011758 Flavoprotein; Region: Flavoprotein; pfam02441 391037011759 prenyltransferase; Reviewed; Region: ubiA; PRK12888 391037011760 UbiA prenyltransferase family; Region: UbiA; pfam01040 391037011761 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 391037011762 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 391037011763 ResB-like family; Region: ResB; pfam05140 391037011764 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 391037011765 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 391037011766 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 391037011767 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391037011768 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391037011769 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037011770 catalytic residues [active] 391037011771 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037011772 catalytic core [active] 391037011773 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 391037011774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037011775 inhibitor-cofactor binding pocket; inhibition site 391037011776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037011777 catalytic residue [active] 391037011778 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391037011779 anti sigma factor interaction site; other site 391037011780 regulatory phosphorylation site [posttranslational modification]; other site 391037011781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037011782 Response regulator receiver domain; Region: Response_reg; pfam00072 391037011783 active site 391037011784 phosphorylation site [posttranslational modification] 391037011785 intermolecular recognition site; other site 391037011786 dimerization interface [polypeptide binding]; other site 391037011787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037011788 dimerization interface [polypeptide binding]; other site 391037011789 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 391037011790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037011791 dimerization interface [polypeptide binding]; other site 391037011792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037011793 dimerization interface [polypeptide binding]; other site 391037011794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037011795 dimerization interface [polypeptide binding]; other site 391037011796 GAF domain; Region: GAF_2; pfam13185 391037011797 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 391037011798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037011799 ATP binding site [chemical binding]; other site 391037011800 Mg2+ binding site [ion binding]; other site 391037011801 G-X-G motif; other site 391037011802 Response regulator receiver domain; Region: Response_reg; pfam00072 391037011803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037011804 active site 391037011805 phosphorylation site [posttranslational modification] 391037011806 intermolecular recognition site; other site 391037011807 dimerization interface [polypeptide binding]; other site 391037011808 GAF domain; Region: GAF_3; pfam13492 391037011809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391037011810 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391037011811 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 391037011812 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037011813 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391037011814 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391037011815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391037011816 catalytic residue [active] 391037011817 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 391037011818 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 391037011819 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391037011820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037011821 DNA-binding site [nucleotide binding]; DNA binding site 391037011822 FCD domain; Region: FCD; cl11656 391037011823 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391037011824 active site 391037011825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037011826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037011827 putative substrate translocation pore; other site 391037011828 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391037011829 FAD binding domain; Region: FAD_binding_4; pfam01565 391037011830 Berberine and berberine like; Region: BBE; pfam08031 391037011831 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 391037011832 substrate binding site [chemical binding]; other site 391037011833 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037011834 Methyltransferase domain; Region: Methyltransf_12; pfam08242 391037011835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037011836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037011837 non-specific DNA binding site [nucleotide binding]; other site 391037011838 salt bridge; other site 391037011839 sequence-specific DNA binding site [nucleotide binding]; other site 391037011840 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 391037011841 active site 391037011842 catalytic residues [active] 391037011843 metal binding site [ion binding]; metal-binding site 391037011844 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 391037011845 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 391037011846 heme-binding site [chemical binding]; other site 391037011847 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 391037011848 FAD binding pocket [chemical binding]; other site 391037011849 FAD binding motif [chemical binding]; other site 391037011850 phosphate binding motif [ion binding]; other site 391037011851 beta-alpha-beta structure motif; other site 391037011852 NAD binding pocket [chemical binding]; other site 391037011853 CAAX protease self-immunity; Region: Abi; pfam02517 391037011854 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391037011855 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391037011856 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 391037011857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391037011858 catalytic core [active] 391037011859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037011860 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 391037011861 Walker A/P-loop; other site 391037011862 ATP binding site [chemical binding]; other site 391037011863 Q-loop/lid; other site 391037011864 ABC transporter signature motif; other site 391037011865 Walker B; other site 391037011866 D-loop; other site 391037011867 H-loop/switch region; other site 391037011868 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037011869 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037011870 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391037011871 DNA binding site [nucleotide binding] 391037011872 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037011873 Predicted ATPase [General function prediction only]; Region: COG3903 391037011874 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037011875 Cytochrome P450; Region: p450; cl12078 391037011876 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 391037011877 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 391037011878 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037011879 Cytochrome P450; Region: p450; cl12078 391037011880 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391037011881 DDE superfamily endonuclease; Region: DDE_4; pfam13359 391037011882 AAA ATPase domain; Region: AAA_16; pfam13191 391037011883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037011884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037011885 DNA binding residues [nucleotide binding] 391037011886 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037011887 Cytochrome P450; Region: p450; cl12078 391037011888 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391037011889 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011890 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037011891 acyl-activating enzyme (AAE) consensus motif; other site 391037011892 AMP binding site [chemical binding]; other site 391037011893 Condensation domain; Region: Condensation; pfam00668 391037011894 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037011895 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011897 acyl-activating enzyme (AAE) consensus motif; other site 391037011898 AMP binding site [chemical binding]; other site 391037011899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037011900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037011901 S-adenosylmethionine binding site [chemical binding]; other site 391037011902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037011903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011904 Condensation domain; Region: Condensation; pfam00668 391037011905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037011906 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011907 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011908 acyl-activating enzyme (AAE) consensus motif; other site 391037011909 AMP binding site [chemical binding]; other site 391037011910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011911 Condensation domain; Region: Condensation; pfam00668 391037011912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037011913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011915 acyl-activating enzyme (AAE) consensus motif; other site 391037011916 AMP binding site [chemical binding]; other site 391037011917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011918 Condensation domain; Region: Condensation; pfam00668 391037011919 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037011920 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011921 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011922 acyl-activating enzyme (AAE) consensus motif; other site 391037011923 AMP binding site [chemical binding]; other site 391037011924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011925 Condensation domain; Region: Condensation; pfam00668 391037011926 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037011927 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011928 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011929 acyl-activating enzyme (AAE) consensus motif; other site 391037011930 AMP binding site [chemical binding]; other site 391037011931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037011932 S-adenosylmethionine binding site [chemical binding]; other site 391037011933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037011934 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011935 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 391037011936 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037011937 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037011938 acyl-activating enzyme (AAE) consensus motif; other site 391037011939 AMP binding site [chemical binding]; other site 391037011940 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037011941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 391037011942 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 391037011943 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 391037011944 active site 391037011945 metal binding site [ion binding]; metal-binding site 391037011946 nudix motif; other site 391037011947 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 391037011948 acetaldehyde dehydrogenase; Validated; Region: PRK08300 391037011949 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 391037011950 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 391037011951 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 391037011952 active site 391037011953 catalytic residues [active] 391037011954 metal binding site [ion binding]; metal-binding site 391037011955 DmpG-like communication domain; Region: DmpG_comm; pfam07836 391037011956 O-methyltransferase; Region: Methyltransf_2; pfam00891 391037011957 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391037011958 Homeodomain-like domain; Region: HTH_23; pfam13384 391037011959 Winged helix-turn helix; Region: HTH_29; pfam13551 391037011960 Homeodomain-like domain; Region: HTH_32; pfam13565 391037011961 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391037011962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391037011963 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391037011964 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391037011965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037011966 Ligand Binding Site [chemical binding]; other site 391037011967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037011968 Ligand Binding Site [chemical binding]; other site 391037011969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037011970 Ligand Binding Site [chemical binding]; other site 391037011971 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 391037011972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391037011973 Ligand Binding Site [chemical binding]; other site 391037011974 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 391037011975 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 391037011976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391037011977 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 391037011978 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391037011979 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 391037011980 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391037011981 active site 391037011982 metal binding site [ion binding]; metal-binding site 391037011983 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391037011984 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391037011985 dimer interface [polypeptide binding]; other site 391037011986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037011987 catalytic residue [active] 391037011988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037011989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391037011990 putative substrate translocation pore; other site 391037011991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037011992 sequence-specific DNA binding site [nucleotide binding]; other site 391037011993 salt bridge; other site 391037011994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037011995 C factor cell-cell signaling protein; Provisional; Region: PRK09009 391037011996 NAD(P) binding site [chemical binding]; other site 391037011997 active site 391037011998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037011999 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391037012000 NAD(P) binding site [chemical binding]; other site 391037012001 active site 391037012002 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 391037012003 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 391037012004 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391037012005 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391037012006 Walker A/P-loop; other site 391037012007 ATP binding site [chemical binding]; other site 391037012008 Q-loop/lid; other site 391037012009 ABC transporter signature motif; other site 391037012010 Walker B; other site 391037012011 D-loop; other site 391037012012 H-loop/switch region; other site 391037012013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037012014 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 391037012015 Walker A/P-loop; other site 391037012016 ATP binding site [chemical binding]; other site 391037012017 Q-loop/lid; other site 391037012018 ABC transporter signature motif; other site 391037012019 Walker B; other site 391037012020 D-loop; other site 391037012021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391037012022 short chain dehydrogenase; Provisional; Region: PRK08219 391037012023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037012024 NAD(P) binding site [chemical binding]; other site 391037012025 active site 391037012026 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 391037012027 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 391037012028 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 391037012029 Predicted ATPase [General function prediction only]; Region: COG3903 391037012030 glycerol kinase; Provisional; Region: glpK; PRK00047 391037012031 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 391037012032 N- and C-terminal domain interface [polypeptide binding]; other site 391037012033 active site 391037012034 MgATP binding site [chemical binding]; other site 391037012035 catalytic site [active] 391037012036 metal binding site [ion binding]; metal-binding site 391037012037 putative homotetramer interface [polypeptide binding]; other site 391037012038 glycerol binding site [chemical binding]; other site 391037012039 homodimer interface [polypeptide binding]; other site 391037012040 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391037012041 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391037012042 Bacterial transcriptional regulator; Region: IclR; pfam01614 391037012043 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 391037012044 amphipathic channel; other site 391037012045 Asn-Pro-Ala signature motifs; other site 391037012046 glycerol kinase; Provisional; Region: glpK; PRK00047 391037012047 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 391037012048 N- and C-terminal domain interface [polypeptide binding]; other site 391037012049 active site 391037012050 MgATP binding site [chemical binding]; other site 391037012051 catalytic site [active] 391037012052 metal binding site [ion binding]; metal-binding site 391037012053 putative homotetramer interface [polypeptide binding]; other site 391037012054 glycerol binding site [chemical binding]; other site 391037012055 homodimer interface [polypeptide binding]; other site 391037012056 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391037012057 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 391037012058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037012059 dimerization interface [polypeptide binding]; other site 391037012060 putative DNA binding site [nucleotide binding]; other site 391037012061 putative Zn2+ binding site [ion binding]; other site 391037012062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391037012063 DsrC like protein; Region: DsrC; pfam04358 391037012064 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 391037012065 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 391037012066 OsmC-like protein; Region: OsmC; pfam02566 391037012067 Fructosamine kinase; Region: Fructosamin_kin; cl17579 391037012068 Phosphotransferase enzyme family; Region: APH; pfam01636 391037012069 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391037012070 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391037012071 ligand binding site [chemical binding]; other site 391037012072 flexible hinge region; other site 391037012073 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391037012074 putative switch regulator; other site 391037012075 non-specific DNA interactions [nucleotide binding]; other site 391037012076 DNA binding site [nucleotide binding] 391037012077 sequence specific DNA binding site [nucleotide binding]; other site 391037012078 putative cAMP binding site [chemical binding]; other site 391037012079 hybrid cluster protein; Provisional; Region: PRK05290 391037012080 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391037012081 ACS interaction site; other site 391037012082 CODH interaction site; other site 391037012083 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391037012084 ACS interaction site; other site 391037012085 CODH interaction site; other site 391037012086 metal cluster binding site [ion binding]; other site 391037012087 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 391037012088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391037012089 catalytic loop [active] 391037012090 iron binding site [ion binding]; other site 391037012091 Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210 391037012092 FAD binding pocket [chemical binding]; other site 391037012093 FAD binding motif [chemical binding]; other site 391037012094 phosphate binding motif [ion binding]; other site 391037012095 beta-alpha-beta structure motif; other site 391037012096 NAD binding pocket [chemical binding]; other site 391037012097 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391037012098 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391037012099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037012100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037012101 dimerization interface [polypeptide binding]; other site 391037012102 putative DNA binding site [nucleotide binding]; other site 391037012103 putative Zn2+ binding site [ion binding]; other site 391037012104 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 391037012105 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391037012106 SnoaL-like domain; Region: SnoaL_2; pfam12680 391037012107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391037012108 putative DNA binding site [nucleotide binding]; other site 391037012109 putative Zn2+ binding site [ion binding]; other site 391037012110 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391037012111 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391037012112 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391037012113 NlpC/P60 family; Region: NLPC_P60; pfam00877 391037012114 RibD C-terminal domain; Region: RibD_C; cl17279 391037012115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037012116 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391037012117 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 391037012118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391037012119 ATP binding site [chemical binding]; other site 391037012120 putative Mg++ binding site [ion binding]; other site 391037012121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391037012122 nucleotide binding region [chemical binding]; other site 391037012123 ATP-binding site [chemical binding]; other site 391037012124 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 391037012125 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 391037012126 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 391037012127 active site 391037012128 putative catalytic site [active] 391037012129 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037012130 Leucine carboxyl methyltransferase; Region: LCM; cl01306 391037012131 BioY family; Region: BioY; pfam02632 391037012132 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 391037012133 Domain of unknown function (DUF385); Region: DUF385; pfam04075 391037012134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 391037012135 MOSC domain; Region: MOSC; pfam03473 391037012136 Domain of unknown function (DUF955); Region: DUF955; cl01076 391037012137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391037012138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037012139 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391037012140 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 391037012141 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391037012142 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 391037012143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037012144 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391037012145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391037012146 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391037012147 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012148 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012149 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012150 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012151 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012152 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 391037012153 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 391037012154 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391037012155 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391037012156 Walker A/P-loop; other site 391037012157 ATP binding site [chemical binding]; other site 391037012158 Q-loop/lid; other site 391037012159 ABC transporter signature motif; other site 391037012160 Walker B; other site 391037012161 D-loop; other site 391037012162 H-loop/switch region; other site 391037012163 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391037012164 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 391037012165 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391037012166 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391037012167 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391037012168 active site 391037012169 HIGH motif; other site 391037012170 nucleotide binding site [chemical binding]; other site 391037012171 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391037012172 KMSKS motif; other site 391037012173 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 391037012174 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391037012175 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 391037012176 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037012177 active site 391037012178 catalytic residues [active] 391037012179 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037012180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037012181 motif II; other site 391037012182 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 391037012183 CGNR zinc finger; Region: zf-CGNR; pfam11706 391037012184 Putative zinc-finger; Region: zf-HC2; pfam13490 391037012185 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 391037012186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037012187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037012188 DNA binding residues [nucleotide binding] 391037012189 mercuric reductase; Validated; Region: PRK06370 391037012190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037012191 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391037012192 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391037012193 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391037012194 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391037012195 homotrimer interaction site [polypeptide binding]; other site 391037012196 putative active site [active] 391037012197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037012198 WHG domain; Region: WHG; pfam13305 391037012199 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 391037012200 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391037012201 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391037012202 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 391037012203 active sites [active] 391037012204 tetramer interface [polypeptide binding]; other site 391037012205 fumarate hydratase; Provisional; Region: PRK15389 391037012206 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 391037012207 Fumarase C-terminus; Region: Fumerase_C; pfam05683 391037012208 PQQ-like domain; Region: PQQ_2; pfam13360 391037012209 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037012210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391037012211 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391037012212 AsnC family; Region: AsnC_trans_reg; pfam01037 391037012213 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 391037012214 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 391037012215 dimer interface [polypeptide binding]; other site 391037012216 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 391037012217 active site 391037012218 Fe binding site [ion binding]; other site 391037012219 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 391037012220 RDD family; Region: RDD; pfam06271 391037012221 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 391037012222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037012223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037012224 homodimer interface [polypeptide binding]; other site 391037012225 catalytic residue [active] 391037012226 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 391037012227 PQQ-like domain; Region: PQQ_2; pfam13360 391037012228 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391037012229 hydrophobic ligand binding site; other site 391037012230 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037012231 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 391037012232 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 391037012233 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391037012234 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 391037012235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037012236 binding surface 391037012237 TPR motif; other site 391037012238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037012239 binding surface 391037012240 TPR motif; other site 391037012241 TPR repeat; Region: TPR_11; pfam13414 391037012242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391037012243 TPR repeat; Region: TPR_11; pfam13414 391037012244 binding surface 391037012245 TPR motif; other site 391037012246 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 391037012247 homotrimer interaction site [polypeptide binding]; other site 391037012248 zinc binding site [ion binding]; other site 391037012249 CDP-binding sites; other site 391037012250 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391037012251 dimer interface; other site 391037012252 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 391037012253 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391037012254 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 391037012255 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391037012256 active site 391037012257 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391037012258 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037012259 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037012260 active site 391037012261 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 391037012262 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391037012263 UbiA prenyltransferase family; Region: UbiA; pfam01040 391037012264 DNA repair protein RadA; Provisional; Region: PRK11823 391037012265 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391037012266 Walker A motif; other site 391037012267 ATP binding site [chemical binding]; other site 391037012268 Walker B motif; other site 391037012269 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391037012270 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 391037012271 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 391037012272 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 391037012273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037012274 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391037012275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391037012276 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 391037012277 active site 391037012278 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391037012279 active site 391037012280 catalytic residues [active] 391037012281 metal binding site [ion binding]; metal-binding site 391037012282 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391037012283 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391037012284 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391037012285 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391037012286 minor groove reading motif; other site 391037012287 helix-hairpin-helix signature motif; other site 391037012288 active site 391037012289 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 391037012290 Clp protease ATP binding subunit; Region: clpC; CHL00095 391037012291 Clp amino terminal domain; Region: Clp_N; pfam02861 391037012292 Clp amino terminal domain; Region: Clp_N; pfam02861 391037012293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037012294 Walker A motif; other site 391037012295 ATP binding site [chemical binding]; other site 391037012296 Walker B motif; other site 391037012297 arginine finger; other site 391037012298 UvrB/uvrC motif; Region: UVR; pfam02151 391037012299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037012300 Walker A motif; other site 391037012301 ATP binding site [chemical binding]; other site 391037012302 Walker B motif; other site 391037012303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391037012304 Lsr2; Region: Lsr2; pfam11774 391037012305 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 391037012306 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 391037012307 dimer interface [polypeptide binding]; other site 391037012308 putative anticodon binding site; other site 391037012309 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391037012310 motif 1; other site 391037012311 dimer interface [polypeptide binding]; other site 391037012312 active site 391037012313 motif 2; other site 391037012314 motif 3; other site 391037012315 pantothenate kinase; Reviewed; Region: PRK13318 391037012316 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 391037012317 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 391037012318 active site 391037012319 L-aspartate oxidase; Provisional; Region: PRK07804 391037012320 L-aspartate oxidase; Provisional; Region: PRK06175 391037012321 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391037012322 Septum formation; Region: Septum_form; pfam13845 391037012323 Septum formation; Region: Septum_form; pfam13845 391037012324 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 391037012325 tetramerization interface [polypeptide binding]; other site 391037012326 active site 391037012327 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 391037012328 pantoate--beta-alanine ligase; Region: panC; TIGR00018 391037012329 active site 391037012330 nucleotide binding site [chemical binding]; other site 391037012331 HIGH motif; other site 391037012332 KMSKS motif; other site 391037012333 Rossmann-like domain; Region: Rossmann-like; pfam10727 391037012334 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 391037012335 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 391037012336 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 391037012337 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 391037012338 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391037012339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037012340 ABC-ATPase subunit interface; other site 391037012341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037012342 ABC-ATPase subunit interface; other site 391037012343 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391037012344 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 391037012345 Walker A/P-loop; other site 391037012346 ATP binding site [chemical binding]; other site 391037012347 Q-loop/lid; other site 391037012348 ABC transporter signature motif; other site 391037012349 Walker B; other site 391037012350 D-loop; other site 391037012351 H-loop/switch region; other site 391037012352 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 391037012353 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391037012354 catalytic center binding site [active] 391037012355 ATP binding site [chemical binding]; other site 391037012356 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 391037012357 homooctamer interface [polypeptide binding]; other site 391037012358 active site 391037012359 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391037012360 dihydropteroate synthase; Region: DHPS; TIGR01496 391037012361 substrate binding pocket [chemical binding]; other site 391037012362 dimer interface [polypeptide binding]; other site 391037012363 inhibitor binding site; inhibition site 391037012364 AAA-like domain; Region: AAA_10; pfam12846 391037012365 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14654 391037012366 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391037012367 Peptidase family M23; Region: Peptidase_M23; pfam01551 391037012368 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 391037012369 homodecamer interface [polypeptide binding]; other site 391037012370 GTP cyclohydrolase I; Provisional; Region: PLN03044 391037012371 active site 391037012372 putative catalytic site residues [active] 391037012373 zinc binding site [ion binding]; other site 391037012374 GTP-CH-I/GFRP interaction surface; other site 391037012375 FtsH Extracellular; Region: FtsH_ext; pfam06480 391037012376 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391037012377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037012378 Walker A motif; other site 391037012379 ATP binding site [chemical binding]; other site 391037012380 Walker B motif; other site 391037012381 arginine finger; other site 391037012382 Peptidase family M41; Region: Peptidase_M41; pfam01434 391037012383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037012384 active site 391037012385 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 391037012386 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391037012387 conserved cys residue [active] 391037012388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391037012389 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391037012390 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 391037012391 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 391037012392 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 391037012393 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 391037012394 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 391037012395 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 391037012396 dimer interface [polypeptide binding]; other site 391037012397 substrate binding site [chemical binding]; other site 391037012398 metal binding sites [ion binding]; metal-binding site 391037012399 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 391037012400 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 391037012401 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012402 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 391037012403 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012404 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012405 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391037012406 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 391037012407 active site 391037012408 catalytic residues [active] 391037012409 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 391037012410 active site 391037012411 Colicin V production protein; Region: Colicin_V; pfam02674 391037012412 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391037012413 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391037012414 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391037012415 putative active site [active] 391037012416 putative CoA binding site [chemical binding]; other site 391037012417 nudix motif; other site 391037012418 metal binding site [ion binding]; metal-binding site 391037012419 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391037012420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037012421 catalytic residues [active] 391037012422 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391037012423 endonuclease III; Region: ENDO3c; smart00478 391037012424 minor groove reading motif; other site 391037012425 helix-hairpin-helix signature motif; other site 391037012426 substrate binding pocket [chemical binding]; other site 391037012427 active site 391037012428 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 391037012429 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 391037012430 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 391037012431 putative active site [active] 391037012432 putative metal binding site [ion binding]; other site 391037012433 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 391037012434 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391037012435 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391037012436 ligand binding site [chemical binding]; other site 391037012437 flexible hinge region; other site 391037012438 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391037012439 putative switch regulator; other site 391037012440 non-specific DNA interactions [nucleotide binding]; other site 391037012441 DNA binding site [nucleotide binding] 391037012442 sequence specific DNA binding site [nucleotide binding]; other site 391037012443 putative cAMP binding site [chemical binding]; other site 391037012444 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 391037012445 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 391037012446 Wyosine base formation; Region: Wyosine_form; pfam08608 391037012447 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391037012448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037012449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391037012450 active site 391037012451 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391037012452 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391037012453 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391037012454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391037012455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037012456 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391037012457 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391037012458 carboxyltransferase (CT) interaction site; other site 391037012459 biotinylation site [posttranslational modification]; other site 391037012460 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391037012461 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391037012462 active site 391037012463 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 391037012464 active site 391037012465 NTP binding site [chemical binding]; other site 391037012466 metal binding triad [ion binding]; metal-binding site 391037012467 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391037012468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391037012469 DNA-binding site [nucleotide binding]; DNA binding site 391037012470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037012471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391037012472 nucleotide binding site [chemical binding]; other site 391037012473 Uncharacterized conserved protein [Function unknown]; Region: COG5476 391037012474 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 391037012475 MlrC C-terminus; Region: MlrC_C; pfam07171 391037012476 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391037012477 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 391037012478 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391037012479 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391037012480 nucleotide binding site [chemical binding]; other site 391037012481 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391037012482 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 391037012483 peptide binding site [polypeptide binding]; other site 391037012484 dimer interface [polypeptide binding]; other site 391037012485 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391037012486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037012487 dimer interface [polypeptide binding]; other site 391037012488 conserved gate region; other site 391037012489 putative PBP binding loops; other site 391037012490 ABC-ATPase subunit interface; other site 391037012491 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 391037012492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391037012493 dimer interface [polypeptide binding]; other site 391037012494 conserved gate region; other site 391037012495 putative PBP binding loops; other site 391037012496 ABC-ATPase subunit interface; other site 391037012497 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391037012498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037012499 Walker A/P-loop; other site 391037012500 ATP binding site [chemical binding]; other site 391037012501 Q-loop/lid; other site 391037012502 ABC transporter signature motif; other site 391037012503 Walker B; other site 391037012504 D-loop; other site 391037012505 H-loop/switch region; other site 391037012506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391037012507 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 391037012508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391037012509 Walker A/P-loop; other site 391037012510 ATP binding site [chemical binding]; other site 391037012511 Q-loop/lid; other site 391037012512 ABC transporter signature motif; other site 391037012513 Walker B; other site 391037012514 D-loop; other site 391037012515 H-loop/switch region; other site 391037012516 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391037012517 CutC family; Region: CutC; cl01218 391037012518 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 391037012519 putative phosphatase; Provisional; Region: PRK11587 391037012520 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391037012521 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391037012522 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391037012523 active site 391037012524 ATP binding site [chemical binding]; other site 391037012525 substrate binding site [chemical binding]; other site 391037012526 activation loop (A-loop); other site 391037012527 Double zinc ribbon; Region: DZR; pfam12773 391037012528 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 391037012529 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391037012530 cyclase homology domain; Region: CHD; cd07302 391037012531 nucleotidyl binding site; other site 391037012532 metal binding site [ion binding]; metal-binding site 391037012533 dimer interface [polypeptide binding]; other site 391037012534 AAA ATPase domain; Region: AAA_16; pfam13191 391037012535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391037012536 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391037012537 homotrimer interaction site [polypeptide binding]; other site 391037012538 putative active site [active] 391037012539 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 391037012540 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 391037012541 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 391037012542 P loop; other site 391037012543 Nucleotide binding site [chemical binding]; other site 391037012544 DTAP/Switch II; other site 391037012545 Switch I; other site 391037012546 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 391037012547 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 391037012548 DTAP/Switch II; other site 391037012549 Switch I; other site 391037012550 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391037012551 Transcription factor WhiB; Region: Whib; pfam02467 391037012552 Transglycosylase; Region: Transgly; pfam00912 391037012553 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391037012554 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391037012555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 391037012556 Yqey-like protein; Region: YqeY; cl17540 391037012557 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 391037012558 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391037012559 putative active site [active] 391037012560 putative metal binding site [ion binding]; other site 391037012561 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391037012562 dimer interface [polypeptide binding]; other site 391037012563 active site 391037012564 nudix motif; other site 391037012565 ADP-ribose binding site [chemical binding]; other site 391037012566 metal binding site [ion binding]; metal-binding site 391037012567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037012568 non-specific DNA binding site [nucleotide binding]; other site 391037012569 salt bridge; other site 391037012570 sequence-specific DNA binding site [nucleotide binding]; other site 391037012571 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 391037012572 dinuclear metal binding motif [ion binding]; other site 391037012573 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391037012574 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391037012575 DNA binding residues [nucleotide binding] 391037012576 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 391037012577 MarR family; Region: MarR_2; pfam12802 391037012578 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 391037012579 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037012580 putative catalytic residues [active] 391037012581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037012582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391037012583 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 391037012584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037012585 motif II; other site 391037012586 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 391037012587 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391037012588 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391037012589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391037012590 RNA binding surface [nucleotide binding]; other site 391037012591 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391037012592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037012593 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391037012594 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037012595 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037012596 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391037012597 TAP-like protein; Region: Abhydrolase_4; pfam08386 391037012598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037012599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037012600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037012601 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391037012602 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 391037012603 dimerization interface [polypeptide binding]; other site 391037012604 DPS ferroxidase diiron center [ion binding]; other site 391037012605 ion pore; other site 391037012606 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037012607 sugar binding site [chemical binding]; other site 391037012608 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 391037012609 Gp5 N-terminal OB domain; Region: Gp5_OB; pfam06714 391037012610 large tegument protein UL36; Provisional; Region: PHA03247 391037012611 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 391037012612 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 391037012613 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 391037012614 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012615 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 391037012616 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012617 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391037012618 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 391037012619 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 391037012620 Protein of unknown function (DUF690); Region: DUF690; cl04939 391037012621 Right handed beta helix region; Region: Beta_helix; pfam13229 391037012622 Right handed beta helix region; Region: Beta_helix; pfam13229 391037012623 stage V sporulation protein K; Region: spore_V_K; TIGR02881 391037012624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037012625 Walker A motif; other site 391037012626 ATP binding site [chemical binding]; other site 391037012627 Walker B motif; other site 391037012628 arginine finger; other site 391037012629 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 391037012630 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 391037012631 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037012632 AAA ATPase domain; Region: AAA_16; pfam13191 391037012633 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 391037012634 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391037012635 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391037012636 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391037012637 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391037012638 dimerization domain swap beta strand [polypeptide binding]; other site 391037012639 regulatory protein interface [polypeptide binding]; other site 391037012640 active site 391037012641 regulatory phosphorylation site [posttranslational modification]; other site 391037012642 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391037012643 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 391037012644 putative NAD(P) binding site [chemical binding]; other site 391037012645 catalytic Zn binding site [ion binding]; other site 391037012646 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391037012647 active site 391037012648 phosphorylation site [posttranslational modification] 391037012649 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 391037012650 active site 391037012651 P-loop; other site 391037012652 phosphorylation site [posttranslational modification] 391037012653 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 391037012654 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 391037012655 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 391037012656 putative substrate binding site [chemical binding]; other site 391037012657 putative ATP binding site [chemical binding]; other site 391037012658 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391037012659 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391037012660 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391037012661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037012662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037012663 DNA binding residues [nucleotide binding] 391037012664 dimerization interface [polypeptide binding]; other site 391037012665 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 391037012666 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391037012667 DNA binding site [nucleotide binding] 391037012668 AAA ATPase domain; Region: AAA_16; pfam13191 391037012669 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037012670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037012671 active site 391037012672 phosphorylation site [posttranslational modification] 391037012673 intermolecular recognition site; other site 391037012674 dimerization interface [polypeptide binding]; other site 391037012675 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037012676 DNA binding site [nucleotide binding] 391037012677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037012678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391037012679 dimerization interface [polypeptide binding]; other site 391037012680 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391037012681 dimer interface [polypeptide binding]; other site 391037012682 phosphorylation site [posttranslational modification] 391037012683 Chitin binding domain; Region: Chitin_bind_3; pfam03067 391037012684 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 391037012685 Domain of unknown function (DUF305); Region: DUF305; pfam03713 391037012686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391037012687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037012688 active site 391037012689 phosphorylation site [posttranslational modification] 391037012690 intermolecular recognition site; other site 391037012691 dimerization interface [polypeptide binding]; other site 391037012692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391037012693 DNA binding residues [nucleotide binding] 391037012694 dimerization interface [polypeptide binding]; other site 391037012695 Histidine kinase; Region: HisKA_3; pfam07730 391037012696 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 391037012697 CAAX protease self-immunity; Region: Abi; pfam02517 391037012698 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 391037012699 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037012700 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391037012701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391037012702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037012703 non-specific DNA binding site [nucleotide binding]; other site 391037012704 salt bridge; other site 391037012705 sequence-specific DNA binding site [nucleotide binding]; other site 391037012706 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037012707 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 391037012708 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 391037012709 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037012710 DNA binding residues [nucleotide binding] 391037012711 dimer interface [polypeptide binding]; other site 391037012712 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391037012713 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037012714 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 391037012715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037012716 Walker A/P-loop; other site 391037012717 ATP binding site [chemical binding]; other site 391037012718 Q-loop/lid; other site 391037012719 ABC transporter signature motif; other site 391037012720 Walker B; other site 391037012721 D-loop; other site 391037012722 H-loop/switch region; other site 391037012723 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 391037012724 dimer interface [polypeptide binding]; other site 391037012725 putative radical transfer pathway; other site 391037012726 diiron center [ion binding]; other site 391037012727 tyrosyl radical; other site 391037012728 ATP cone domain; Region: ATP-cone; pfam03477 391037012729 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 391037012730 Class I ribonucleotide reductase; Region: RNR_I; cd01679 391037012731 active site 391037012732 dimer interface [polypeptide binding]; other site 391037012733 catalytic residues [active] 391037012734 effector binding site; other site 391037012735 R2 peptide binding site; other site 391037012736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391037012737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037012738 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 391037012739 active site 391037012740 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 391037012741 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391037012742 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391037012743 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391037012744 active site 391037012745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037012746 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391037012747 Walker A/P-loop; other site 391037012748 ATP binding site [chemical binding]; other site 391037012749 Q-loop/lid; other site 391037012750 ABC transporter signature motif; other site 391037012751 Walker B; other site 391037012752 D-loop; other site 391037012753 H-loop/switch region; other site 391037012754 Helix-turn-helix domain; Region: HTH_31; pfam13560 391037012755 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037012756 sugar binding site [chemical binding]; other site 391037012757 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 391037012758 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 391037012759 substrate binding pocket [chemical binding]; other site 391037012760 catalytic residues [active] 391037012761 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 391037012762 Methyltransferase domain; Region: Methyltransf_18; pfam12847 391037012763 H+ Antiporter protein; Region: 2A0121; TIGR00900 391037012764 Condensation domain; Region: Condensation; pfam00668 391037012765 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037012766 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037012767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391037012768 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037012769 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037012770 acyl-activating enzyme (AAE) consensus motif; other site 391037012771 AMP binding site [chemical binding]; other site 391037012772 thioester reductase domain; Region: Thioester-redct; TIGR01746 391037012773 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 391037012774 putative NAD(P) binding site [chemical binding]; other site 391037012775 active site 391037012776 putative substrate binding site [chemical binding]; other site 391037012777 Condensation domain; Region: Condensation; pfam00668 391037012778 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037012779 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037012780 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 391037012781 acyl-activating enzyme (AAE) consensus motif; other site 391037012782 AMP binding site [chemical binding]; other site 391037012783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037012784 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037012785 hypothetical protein; Provisional; Region: PRK07236 391037012786 Condensation domain; Region: Condensation; pfam00668 391037012787 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391037012788 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 391037012789 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391037012790 acyl-activating enzyme (AAE) consensus motif; other site 391037012791 AMP binding site [chemical binding]; other site 391037012792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037012793 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 391037012794 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391037012795 acyl-activating enzyme (AAE) consensus motif; other site 391037012796 AMP binding site [chemical binding]; other site 391037012797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391037012798 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 391037012799 MbtH-like protein; Region: MbtH; cl01279 391037012800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037012801 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 391037012802 Walker A/P-loop; other site 391037012803 ATP binding site [chemical binding]; other site 391037012804 Q-loop/lid; other site 391037012805 ABC transporter signature motif; other site 391037012806 Walker B; other site 391037012807 D-loop; other site 391037012808 H-loop/switch region; other site 391037012809 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 391037012810 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 391037012811 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 391037012812 putative sugar binding sites [chemical binding]; other site 391037012813 Q-X-W motif; other site 391037012814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037012815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037012816 non-specific DNA binding site [nucleotide binding]; other site 391037012817 salt bridge; other site 391037012818 sequence-specific DNA binding site [nucleotide binding]; other site 391037012819 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037012820 Cytochrome P450; Region: p450; cl12078 391037012821 RNHCP domain; Region: RNHCP; pfam12647 391037012822 RNHCP domain; Region: RNHCP; pfam12647 391037012823 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391037012824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037012825 motif II; other site 391037012826 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 391037012827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391037012828 putative metal binding site [ion binding]; other site 391037012829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391037012830 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391037012831 non-specific DNA binding site [nucleotide binding]; other site 391037012832 salt bridge; other site 391037012833 sequence-specific DNA binding site [nucleotide binding]; other site 391037012834 Predicted transcriptional regulator [Transcription]; Region: COG2944 391037012835 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 391037012836 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 391037012837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037012838 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 391037012839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037012840 S-adenosylmethionine binding site [chemical binding]; other site 391037012841 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 391037012842 YcfA-like protein; Region: YcfA; cl00752 391037012843 transposase; Provisional; Region: PRK06526 391037012844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391037012845 Walker A motif; other site 391037012846 ATP binding site [chemical binding]; other site 391037012847 Walker B motif; other site 391037012848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391037012849 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391037012850 DNA-binding interface [nucleotide binding]; DNA binding site 391037012851 Integrase core domain; Region: rve; pfam00665 391037012852 Integrase core domain; Region: rve_3; cl15866 391037012853 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 391037012854 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391037012855 DNA binding residues [nucleotide binding] 391037012856 B12 binding domain; Region: B12-binding_2; cl03653 391037012857 isopentenyl-diphosphate delta-isomerase; Provisional; Region: PRK03759 391037012858 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 391037012859 nudix motif; other site 391037012860 phytoene desaturase; Region: crtI_fam; TIGR02734 391037012861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037012862 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391037012863 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391037012864 substrate binding pocket [chemical binding]; other site 391037012865 chain length determination region; other site 391037012866 substrate-Mg2+ binding site; other site 391037012867 catalytic residues [active] 391037012868 aspartate-rich region 1; other site 391037012869 active site lid residues [active] 391037012870 aspartate-rich region 2; other site 391037012871 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 391037012872 active site lid residues [active] 391037012873 substrate binding pocket [chemical binding]; other site 391037012874 catalytic residues [active] 391037012875 substrate-Mg2+ binding site; other site 391037012876 aspartate-rich region 1; other site 391037012877 aspartate-rich region 2; other site 391037012878 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037012879 Cytochrome P450; Region: p450; cl12078 391037012880 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 391037012881 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 391037012882 acyl-activating enzyme (AAE) consensus motif; other site 391037012883 active site 391037012884 AMP binding site [chemical binding]; other site 391037012885 substrate binding site [chemical binding]; other site 391037012886 AAA ATPase domain; Region: AAA_16; pfam13191 391037012887 AAA domain; Region: AAA_22; pfam13401 391037012888 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 391037012889 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391037012890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391037012891 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 391037012892 Walker A/P-loop; other site 391037012893 ATP binding site [chemical binding]; other site 391037012894 Q-loop/lid; other site 391037012895 ABC transporter signature motif; other site 391037012896 Walker B; other site 391037012897 D-loop; other site 391037012898 H-loop/switch region; other site 391037012899 Predicted flavoprotein [General function prediction only]; Region: COG0431 391037012900 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391037012901 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391037012902 Epoxide hydrolase N terminus; Region: EHN; pfam06441 391037012903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391037012904 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391037012905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037012906 inhibitor-cofactor binding pocket; inhibition site 391037012907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037012908 catalytic residue [active] 391037012909 choline dehydrogenase; Validated; Region: PRK02106 391037012910 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391037012911 YCII-related domain; Region: YCII; cl00999 391037012912 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391037012913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391037012914 inhibitor-cofactor binding pocket; inhibition site 391037012915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037012916 catalytic residue [active] 391037012917 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 391037012918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391037012919 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391037012920 classical (c) SDRs; Region: SDR_c; cd05233 391037012921 NAD(P) binding site [chemical binding]; other site 391037012922 active site 391037012923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391037012924 Cytochrome P450; Region: p450; cl12078 391037012925 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391037012926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391037012927 S-adenosylmethionine binding site [chemical binding]; other site 391037012928 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 391037012929 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391037012930 active site 391037012931 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391037012932 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391037012933 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 391037012934 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391037012935 putative NADP binding site [chemical binding]; other site 391037012936 active site 391037012937 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 391037012938 conserved hypothetical protein; Region: TIGR02246 391037012939 SnoaL-like domain; Region: SnoaL_3; pfam13474 391037012940 FAD binding domain; Region: FAD_binding_4; pfam01565 391037012941 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 391037012942 O-methyltransferase; Region: Methyltransf_2; pfam00891 391037012943 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391037012944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037012945 mercuric reductase; Validated; Region: PRK06370 391037012946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037012947 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391037012948 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391037012949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391037012950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391037012951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391037012952 salt bridge; other site 391037012953 non-specific DNA binding site [nucleotide binding]; other site 391037012954 sequence-specific DNA binding site [nucleotide binding]; other site 391037012955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391037012956 substrate binding site [chemical binding]; other site 391037012957 oxyanion hole (OAH) forming residues; other site 391037012958 trimer interface [polypeptide binding]; other site 391037012959 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391037012960 putative FMN binding site [chemical binding]; other site 391037012961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391037012962 TadE-like protein; Region: TadE; pfam07811 391037012963 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391037012964 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391037012965 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 391037012966 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391037012967 Walker A motif; other site 391037012968 ATP binding site [chemical binding]; other site 391037012969 Walker B motif; other site 391037012970 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 391037012971 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 391037012972 NUDIX domain; Region: NUDIX; pfam00293 391037012973 nudix motif; other site 391037012974 ferrochelatase; Region: PLN02449 391037012975 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 391037012976 Divergent AAA domain; Region: AAA_4; pfam04326 391037012977 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 391037012978 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391037012979 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391037012980 NAD(P) binding site [chemical binding]; other site 391037012981 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 391037012982 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 391037012983 DNA binding residues [nucleotide binding] 391037012984 dimer interface [polypeptide binding]; other site 391037012985 [2Fe-2S] cluster binding site [ion binding]; other site 391037012986 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391037012987 TPP-binding site [chemical binding]; other site 391037012988 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391037012989 PYR/PP interface [polypeptide binding]; other site 391037012990 dimer interface [polypeptide binding]; other site 391037012991 TPP binding site [chemical binding]; other site 391037012992 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 391037012993 Ligand binding site; other site 391037012994 Putative Catalytic site; other site 391037012995 DXD motif; other site 391037012996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037012997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037012998 dimer interface [polypeptide binding]; other site 391037012999 phosphorylation site [posttranslational modification] 391037013000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391037013001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037013002 active site 391037013003 phosphorylation site [posttranslational modification] 391037013004 intermolecular recognition site; other site 391037013005 dimerization interface [polypeptide binding]; other site 391037013006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391037013007 DNA binding site [nucleotide binding] 391037013008 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 391037013009 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391037013010 dimer interface [polypeptide binding]; other site 391037013011 active site 391037013012 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 391037013013 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 391037013014 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 391037013015 Rhomboid family; Region: Rhomboid; pfam01694 391037013016 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 391037013017 active site 391037013018 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 391037013019 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 391037013020 oligomer interface [polypeptide binding]; other site 391037013021 metal binding site [ion binding]; metal-binding site 391037013022 metal binding site [ion binding]; metal-binding site 391037013023 putative Cl binding site [ion binding]; other site 391037013024 basic sphincter; other site 391037013025 hydrophobic gate; other site 391037013026 periplasmic entrance; other site 391037013027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037013028 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 391037013029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037013030 homodimer interface [polypeptide binding]; other site 391037013031 catalytic residue [active] 391037013032 FOG: CBS domain [General function prediction only]; Region: COG0517 391037013033 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 391037013034 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391037013035 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 391037013036 active site 391037013037 metal-binding site 391037013038 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 391037013039 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 391037013040 active site 391037013041 metal binding site [ion binding]; metal-binding site 391037013042 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391037013043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391037013044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391037013045 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 391037013046 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 391037013047 putative DNA binding site [nucleotide binding]; other site 391037013048 catalytic residue [active] 391037013049 putative H2TH interface [polypeptide binding]; other site 391037013050 putative catalytic residues [active] 391037013051 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391037013052 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391037013053 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 391037013054 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391037013055 Histidine kinase; Region: His_kinase; pfam06580 391037013056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037013057 ATP binding site [chemical binding]; other site 391037013058 Mg2+ binding site [ion binding]; other site 391037013059 G-X-G motif; other site 391037013060 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 391037013061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391037013062 active site 391037013063 phosphorylation site [posttranslational modification] 391037013064 intermolecular recognition site; other site 391037013065 dimerization interface [polypeptide binding]; other site 391037013066 LytTr DNA-binding domain; Region: LytTR; smart00850 391037013067 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 391037013068 Na binding site [ion binding]; other site 391037013069 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 391037013070 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391037013071 Walker A/P-loop; other site 391037013072 ATP binding site [chemical binding]; other site 391037013073 Q-loop/lid; other site 391037013074 ABC transporter signature motif; other site 391037013075 Walker B; other site 391037013076 D-loop; other site 391037013077 H-loop/switch region; other site 391037013078 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 391037013079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037013080 DNA binding residues [nucleotide binding] 391037013081 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 391037013082 Protein of unknown function, DUF485; Region: DUF485; pfam04341 391037013083 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 391037013084 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 391037013085 Na binding site [ion binding]; other site 391037013086 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391037013087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391037013088 NAD(P) binding site [chemical binding]; other site 391037013089 active site 391037013090 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 391037013091 Transcriptional regulator [Transcription]; Region: LytR; COG1316 391037013092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391037013093 active site residue [active] 391037013094 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391037013095 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 391037013096 putative active site [active] 391037013097 catalytic site [active] 391037013098 putative metal binding site [ion binding]; other site 391037013099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391037013100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391037013101 dimer interface [polypeptide binding]; other site 391037013102 phosphorylation site [posttranslational modification] 391037013103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391037013104 ATP binding site [chemical binding]; other site 391037013105 Mg2+ binding site [ion binding]; other site 391037013106 G-X-G motif; other site 391037013107 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391037013108 arginine deiminase; Provisional; Region: PRK01388 391037013109 Uncharacterized conserved protein [Function unknown]; Region: COG3603 391037013110 Family description; Region: ACT_7; pfam13840 391037013111 prephenate dehydratase; Provisional; Region: PRK11898 391037013112 Prephenate dehydratase; Region: PDT; pfam00800 391037013113 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391037013114 putative L-Phe binding site [chemical binding]; other site 391037013115 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 391037013116 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 391037013117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037013118 active site 391037013119 motif I; other site 391037013120 motif II; other site 391037013121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391037013122 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 391037013123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391037013124 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391037013125 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391037013126 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391037013127 putative ligand binding site [chemical binding]; other site 391037013128 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391037013129 Amidinotransferase; Region: Amidinotransf; cl12043 391037013130 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391037013131 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391037013132 putative DNA binding site [nucleotide binding]; other site 391037013133 putative Zn2+ binding site [ion binding]; other site 391037013134 AsnC family; Region: AsnC_trans_reg; pfam01037 391037013135 Beta propeller domain; Region: Beta_propel; pfam09826 391037013136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391037013137 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 391037013138 Fructosamine kinase; Region: Fructosamin_kin; cl17579 391037013139 Phosphotransferase enzyme family; Region: APH; pfam01636 391037013140 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 391037013141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391037013142 FeS/SAM binding site; other site 391037013143 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391037013144 Ubiquitin-like proteins; Region: UBQ; cl00155 391037013145 charged pocket; other site 391037013146 hydrophobic patch; other site 391037013147 phosphodiesterase YaeI; Provisional; Region: PRK11340 391037013148 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 391037013149 putative active site [active] 391037013150 putative metal binding site [ion binding]; other site 391037013151 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 391037013152 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 391037013153 Part of AAA domain; Region: AAA_19; pfam13245 391037013154 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391037013155 Family description; Region: UvrD_C_2; pfam13538 391037013156 AAA ATPase domain; Region: AAA_16; pfam13191 391037013157 Predicted acetyltransferase [General function prediction only]; Region: COG3153 391037013158 DoxX; Region: DoxX; pfam07681 391037013159 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 391037013160 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391037013161 MoaE homodimer interface [polypeptide binding]; other site 391037013162 MoaD interaction [polypeptide binding]; other site 391037013163 active site residues [active] 391037013164 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391037013165 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391037013166 dimer interface [polypeptide binding]; other site 391037013167 putative functional site; other site 391037013168 putative MPT binding site; other site 391037013169 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 391037013170 MPT binding site; other site 391037013171 trimer interface [polypeptide binding]; other site 391037013172 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 391037013173 trimer interface [polypeptide binding]; other site 391037013174 dimer interface [polypeptide binding]; other site 391037013175 putative active site [active] 391037013176 GAF domain; Region: GAF_2; pfam13185 391037013177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391037013178 metal binding site [ion binding]; metal-binding site 391037013179 active site 391037013180 I-site; other site 391037013181 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391037013182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391037013183 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 391037013184 replicative DNA helicase; Validated; Region: PRK07773 391037013185 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391037013186 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391037013187 Walker A motif; other site 391037013188 ATP binding site [chemical binding]; other site 391037013189 Walker B motif; other site 391037013190 DNA binding loops [nucleotide binding] 391037013191 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 391037013192 protein-splicing catalytic site; other site 391037013193 thioester formation/cholesterol transfer; other site 391037013194 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 391037013195 protein-splicing catalytic site; other site 391037013196 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391037013197 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 391037013198 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391037013199 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391037013200 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 391037013201 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391037013202 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391037013203 dimer interface [polypeptide binding]; other site 391037013204 ssDNA binding site [nucleotide binding]; other site 391037013205 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391037013206 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 391037013207 endonuclease IV; Provisional; Region: PRK01060 391037013208 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 391037013209 AP (apurinic/apyrimidinic) site pocket; other site 391037013210 DNA interaction; other site 391037013211 Metal-binding active site; metal-binding site 391037013212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 391037013213 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 391037013214 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 391037013215 active site 391037013216 catalytic triad [active] 391037013217 oxyanion hole [active] 391037013218 Predicted integral membrane protein [Function unknown]; Region: COG5650 391037013219 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 391037013220 Transglycosylase; Region: Transgly; pfam00912 391037013221 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391037013222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391037013223 Predicted transcriptional regulators [Transcription]; Region: COG1695 391037013224 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 391037013225 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 391037013226 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 391037013227 putative acetyltransferase; Provisional; Region: PRK03624 391037013228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391037013229 Coenzyme A binding pocket [chemical binding]; other site 391037013230 Domain of unknown function (DUF397); Region: DUF397; pfam04149 391037013231 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 391037013232 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 391037013233 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391037013234 DNA binding site [nucleotide binding] 391037013235 active site 391037013236 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 391037013237 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391037013238 DNA binding residues [nucleotide binding] 391037013239 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 391037013240 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 391037013241 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391037013242 active site 391037013243 NTP binding site [chemical binding]; other site 391037013244 metal binding triad [ion binding]; metal-binding site 391037013245 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391037013246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391037013247 Zn2+ binding site [ion binding]; other site 391037013248 Mg2+ binding site [ion binding]; other site 391037013249 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 391037013250 MviN-like protein; Region: MVIN; pfam03023 391037013251 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391037013252 active site 391037013253 ATP binding site [chemical binding]; other site 391037013254 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391037013255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391037013256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391037013257 DNA binding residues [nucleotide binding] 391037013258 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391037013259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391037013260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391037013261 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391037013262 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391037013263 catalytic residues [active] 391037013264 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 391037013265 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037013266 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391037013267 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 391037013268 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391037013269 active site 391037013270 metal binding site [ion binding]; metal-binding site 391037013271 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 391037013272 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 391037013273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391037013274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391037013275 homodimer interface [polypeptide binding]; other site 391037013276 catalytic residue [active] 391037013277 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391037013278 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391037013279 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391037013280 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391037013281 ParB-like nuclease domain; Region: ParBc; pfam02195 391037013282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391037013283 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391037013284 Magnesium ion binding site [ion binding]; other site 391037013285 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 391037013286 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 391037013287 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 391037013288 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 391037013289 G-X-X-G motif; other site 391037013290 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 391037013291 RxxxH motif; other site 391037013292 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 391037013293 Haemolytic domain; Region: Haemolytic; pfam01809 391037013294 Ribonuclease P; Region: Ribonuclease_P; cl00457 391037013295 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399