-- dump date 20140620_042906 -- class Genbank::misc_feature -- table misc_feature_note -- id note 369723000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 369723000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723000003 Walker A motif; other site 369723000004 ATP binding site [chemical binding]; other site 369723000005 Walker B motif; other site 369723000006 arginine finger; other site 369723000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 369723000008 DnaA box-binding interface [nucleotide binding]; other site 369723000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 369723000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 369723000011 putative DNA binding surface [nucleotide binding]; other site 369723000012 dimer interface [polypeptide binding]; other site 369723000013 beta-clamp/clamp loader binding surface; other site 369723000014 beta-clamp/translesion DNA polymerase binding surface; other site 369723000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 369723000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 369723000017 recombination protein F; Reviewed; Region: recF; PRK00064 369723000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 369723000019 Walker A/P-loop; other site 369723000020 ATP binding site [chemical binding]; other site 369723000021 Q-loop/lid; other site 369723000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723000023 ABC transporter signature motif; other site 369723000024 Walker B; other site 369723000025 D-loop; other site 369723000026 H-loop/switch region; other site 369723000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 369723000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 369723000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723000030 Mg2+ binding site [ion binding]; other site 369723000031 G-X-G motif; other site 369723000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 369723000033 anchoring element; other site 369723000034 dimer interface [polypeptide binding]; other site 369723000035 ATP binding site [chemical binding]; other site 369723000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 369723000037 active site 369723000038 putative metal-binding site [ion binding]; other site 369723000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 369723000040 DNA gyrase subunit A; Validated; Region: PRK05560 369723000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 369723000042 CAP-like domain; other site 369723000043 active site 369723000044 primary dimer interface [polypeptide binding]; other site 369723000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 369723000052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 369723000053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723000054 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 369723000055 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 369723000056 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723000057 active site 369723000058 HIGH motif; other site 369723000059 nucleotide binding site [chemical binding]; other site 369723000060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723000061 active site 369723000062 KMSKS motif; other site 369723000063 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 369723000064 tRNA binding surface [nucleotide binding]; other site 369723000065 anticodon binding site; other site 369723000066 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 369723000067 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 369723000068 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 369723000069 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 369723000070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 369723000071 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 369723000072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 369723000073 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 369723000074 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 369723000075 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 369723000076 catalytic residues [active] 369723000077 Fe-S metabolism associated domain; Region: SufE; cl00951 369723000078 FOG: CBS domain [General function prediction only]; Region: COG0517 369723000079 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 369723000080 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 369723000081 active site 369723000082 catalytic triad [active] 369723000083 oxyanion hole [active] 369723000084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723000085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723000086 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 369723000087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723000088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723000089 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 369723000090 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 369723000091 active site 369723000092 catalytic residues [active] 369723000093 metal binding site [ion binding]; metal-binding site 369723000094 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 369723000095 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 369723000096 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 369723000097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723000098 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723000099 active site 369723000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723000101 non-specific DNA binding site [nucleotide binding]; other site 369723000102 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723000103 salt bridge; other site 369723000104 sequence-specific DNA binding site [nucleotide binding]; other site 369723000105 Predicted ATPase [General function prediction only]; Region: COG3903 369723000106 Transcriptional regulators [Transcription]; Region: MarR; COG1846 369723000107 MarR family; Region: MarR_2; pfam12802 369723000108 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 369723000109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723000110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723000111 sequence-specific DNA binding site [nucleotide binding]; other site 369723000112 salt bridge; other site 369723000113 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723000114 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 369723000115 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 369723000116 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 369723000117 calcium binding site 2 [ion binding]; other site 369723000118 active site 369723000119 catalytic triad [active] 369723000120 calcium binding site 1 [ion binding]; other site 369723000121 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 369723000122 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 369723000123 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 369723000124 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 369723000125 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 369723000126 NAD binding site [chemical binding]; other site 369723000127 homotetramer interface [polypeptide binding]; other site 369723000128 homodimer interface [polypeptide binding]; other site 369723000129 active site 369723000130 substrate binding site [chemical binding]; other site 369723000131 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 369723000132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 369723000133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 369723000134 phosphopeptide binding site; other site 369723000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 369723000136 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 369723000137 phosphopeptide binding site; other site 369723000138 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 369723000139 active site 369723000140 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 369723000141 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 369723000142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 369723000143 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 369723000144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723000145 active site 369723000146 ATP binding site [chemical binding]; other site 369723000147 substrate binding site [chemical binding]; other site 369723000148 activation loop (A-loop); other site 369723000149 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 369723000150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723000151 active site 369723000152 ATP binding site [chemical binding]; other site 369723000153 substrate binding site [chemical binding]; other site 369723000154 activation loop (A-loop); other site 369723000155 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723000156 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723000157 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723000158 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 369723000159 Glutamine amidotransferase class-I; Region: GATase; pfam00117 369723000160 glutamine binding [chemical binding]; other site 369723000161 catalytic triad [active] 369723000162 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 369723000163 active site 369723000164 catalytic site [active] 369723000165 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 369723000166 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 369723000167 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 369723000168 4Fe-4S binding domain; Region: Fer4; pfam00037 369723000169 Cysteine-rich domain; Region: CCG; pfam02754 369723000170 Cysteine-rich domain; Region: CCG; pfam02754 369723000171 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 369723000172 NlpC/P60 family; Region: NLPC_P60; pfam00877 369723000173 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 369723000174 trimer interface [polypeptide binding]; other site 369723000175 active site 369723000176 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 369723000177 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 369723000178 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723000179 active site 369723000180 Int/Topo IB signature motif; other site 369723000181 DNA binding site [nucleotide binding] 369723000182 Helix-turn-helix domain; Region: HTH_17; cl17695 369723000183 AAA domain; Region: AAA_25; pfam13481 369723000184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 369723000185 Walker A motif; other site 369723000186 ATP binding site [chemical binding]; other site 369723000187 Walker B motif; other site 369723000188 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 369723000189 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 369723000190 cofactor binding site; other site 369723000191 DNA binding site [nucleotide binding] 369723000192 substrate interaction site [chemical binding]; other site 369723000193 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 369723000194 polymerase nucleotide-binding site; other site 369723000195 DNA-binding residues [nucleotide binding]; DNA binding site 369723000196 nucleotide binding site [chemical binding]; other site 369723000197 primase nucleotide-binding site [nucleotide binding]; other site 369723000198 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 369723000199 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723000200 nudix motif; other site 369723000201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723000202 DNA-binding site [nucleotide binding]; DNA binding site 369723000203 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723000204 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 369723000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723000206 motif II; other site 369723000207 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 369723000208 DNA binding site [nucleotide binding] 369723000209 active site 369723000210 Int/Topo IB signature motif; other site 369723000211 catalytic residues [active] 369723000212 RNA polymerase factor sigma-70; Validated; Region: PRK09047 369723000213 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723000214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723000215 DNA binding residues [nucleotide binding] 369723000216 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 369723000217 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 369723000218 NAD(P) binding site [chemical binding]; other site 369723000219 catalytic residues [active] 369723000220 guanine deaminase; Provisional; Region: PRK09228 369723000221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723000222 active site 369723000223 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 369723000224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000225 Coenzyme A binding pocket [chemical binding]; other site 369723000226 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 369723000227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000228 Coenzyme A binding pocket [chemical binding]; other site 369723000229 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 369723000230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723000231 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723000232 active site 369723000233 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 369723000234 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 369723000235 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 369723000236 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 369723000237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723000238 active site 369723000239 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 369723000240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723000241 catalytic core [active] 369723000242 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 369723000243 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 369723000244 conserved cys residue [active] 369723000245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723000246 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 369723000247 conserved cys residue [active] 369723000248 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 369723000249 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 369723000250 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 369723000251 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 369723000252 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 369723000253 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 369723000254 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 369723000255 putative active site [active] 369723000256 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723000257 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723000258 NHL repeat; Region: NHL; pfam01436 369723000259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723000260 non-specific DNA binding site [nucleotide binding]; other site 369723000261 salt bridge; other site 369723000262 sequence-specific DNA binding site [nucleotide binding]; other site 369723000263 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723000264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723000265 S-adenosylmethionine binding site [chemical binding]; other site 369723000266 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 369723000267 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 369723000268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 369723000269 E3 interaction surface; other site 369723000270 lipoyl attachment site [posttranslational modification]; other site 369723000271 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 369723000272 e3 binding domain; Region: E3_binding; pfam02817 369723000273 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 369723000274 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 369723000275 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 369723000276 alpha subunit interface [polypeptide binding]; other site 369723000277 TPP binding site [chemical binding]; other site 369723000278 heterodimer interface [polypeptide binding]; other site 369723000279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723000280 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 369723000281 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 369723000282 TPP-binding site [chemical binding]; other site 369723000283 tetramer interface [polypeptide binding]; other site 369723000284 heterodimer interface [polypeptide binding]; other site 369723000285 phosphorylation loop region [posttranslational modification] 369723000286 Protein of unknown function (DUF805); Region: DUF805; pfam05656 369723000287 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 369723000288 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 369723000289 nucleotide binding site [chemical binding]; other site 369723000290 NEF interaction site [polypeptide binding]; other site 369723000291 SBD interface [polypeptide binding]; other site 369723000292 GrpE; Region: GrpE; pfam01025 369723000293 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 369723000294 dimer interface [polypeptide binding]; other site 369723000295 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 369723000296 chaperone protein DnaJ; Provisional; Region: PRK14279 369723000297 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 369723000298 HSP70 interaction site [polypeptide binding]; other site 369723000299 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 369723000300 Zn binding sites [ion binding]; other site 369723000301 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 369723000302 dimer interface [polypeptide binding]; other site 369723000303 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 369723000304 DNA binding residues [nucleotide binding] 369723000305 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723000306 putative dimer interface [polypeptide binding]; other site 369723000307 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 369723000308 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 369723000309 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 369723000310 TrkA-C domain; Region: TrkA_C; pfam02080 369723000311 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 369723000312 Clp amino terminal domain; Region: Clp_N; pfam02861 369723000313 Clp amino terminal domain; Region: Clp_N; pfam02861 369723000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723000315 Walker A motif; other site 369723000316 ATP binding site [chemical binding]; other site 369723000317 Walker B motif; other site 369723000318 arginine finger; other site 369723000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723000320 Walker A motif; other site 369723000321 ATP binding site [chemical binding]; other site 369723000322 Walker B motif; other site 369723000323 arginine finger; other site 369723000324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 369723000325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 369723000326 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 369723000327 classical (c) SDRs; Region: SDR_c; cd05233 369723000328 NAD(P) binding site [chemical binding]; other site 369723000329 active site 369723000330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723000331 active site 369723000332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723000333 dimerization interface [polypeptide binding]; other site 369723000334 putative DNA binding site [nucleotide binding]; other site 369723000335 putative Zn2+ binding site [ion binding]; other site 369723000336 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 369723000337 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 369723000338 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 369723000339 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 369723000340 active site 369723000341 intersubunit interface [polypeptide binding]; other site 369723000342 zinc binding site [ion binding]; other site 369723000343 Na+ binding site [ion binding]; other site 369723000344 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 369723000345 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 369723000346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723000347 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 369723000348 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 369723000349 GDP-binding site [chemical binding]; other site 369723000350 ACT binding site; other site 369723000351 IMP binding site; other site 369723000352 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 369723000353 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 369723000354 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 369723000355 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 369723000356 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723000357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723000358 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723000359 active site 369723000360 SCP-2 sterol transfer family; Region: SCP2; pfam02036 369723000361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723000362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723000363 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 369723000364 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 369723000365 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723000366 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723000367 active site 1 [active] 369723000368 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 369723000369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723000370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723000371 NAD(P) binding site [chemical binding]; other site 369723000372 active site 369723000373 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 369723000374 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723000375 dimer interface [polypeptide binding]; other site 369723000376 active site 369723000377 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 369723000378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723000379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723000380 DNA-binding site [nucleotide binding]; DNA binding site 369723000381 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 369723000382 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 369723000383 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 369723000384 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 369723000385 active site 369723000386 HIGH motif; other site 369723000387 KMSK motif region; other site 369723000388 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 369723000389 tRNA binding surface [nucleotide binding]; other site 369723000390 anticodon binding site; other site 369723000391 adenylosuccinate lyase; Region: purB; TIGR00928 369723000392 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 369723000393 tetramer interface [polypeptide binding]; other site 369723000394 Uncharacterized conserved protein [Function unknown]; Region: COG0393 369723000395 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 369723000396 cleavage site 369723000397 active site 369723000398 substrate binding sites [chemical binding]; other site 369723000399 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 369723000400 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 369723000401 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 369723000402 putative active site [active] 369723000403 catalytic triad [active] 369723000404 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 369723000405 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 369723000406 dimerization interface [polypeptide binding]; other site 369723000407 ATP binding site [chemical binding]; other site 369723000408 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 369723000409 dimerization interface [polypeptide binding]; other site 369723000410 ATP binding site [chemical binding]; other site 369723000411 Cna protein B-type domain; Region: Cna_B_2; pfam13715 369723000412 amidophosphoribosyltransferase; Provisional; Region: PRK07847 369723000413 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 369723000414 active site 369723000415 tetramer interface [polypeptide binding]; other site 369723000416 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723000417 active site 369723000418 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 369723000419 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 369723000420 dimerization interface [polypeptide binding]; other site 369723000421 putative ATP binding site [chemical binding]; other site 369723000422 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 369723000423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723000424 FeS/SAM binding site; other site 369723000425 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 369723000426 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 369723000427 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 369723000428 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 369723000429 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 369723000430 NAD binding site [chemical binding]; other site 369723000431 Phe binding site; other site 369723000432 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 369723000433 DNA binding residues [nucleotide binding] 369723000434 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 369723000435 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 369723000436 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723000437 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 369723000438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723000439 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 369723000440 substrate binding site [chemical binding]; other site 369723000441 oxyanion hole (OAH) forming residues; other site 369723000442 trimer interface [polypeptide binding]; other site 369723000443 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 369723000444 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 369723000445 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 369723000446 ligand binding site [chemical binding]; other site 369723000447 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 369723000448 putative hydrophobic ligand binding site [chemical binding]; other site 369723000449 CLM binding site; other site 369723000450 L1 loop; other site 369723000451 DNA binding site [nucleotide binding] 369723000452 MarR family; Region: MarR_2; pfam12802 369723000453 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 369723000454 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 369723000455 homodimer interface [polypeptide binding]; other site 369723000456 active site 369723000457 TDP-binding site; other site 369723000458 acceptor substrate-binding pocket; other site 369723000459 CAAX protease self-immunity; Region: Abi; pfam02517 369723000460 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 369723000461 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 369723000462 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 369723000463 Thioredoxin; Region: Thioredoxin_4; pfam13462 369723000464 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 369723000465 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 369723000466 putative active site [active] 369723000467 redox center [active] 369723000468 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 369723000469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 369723000470 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 369723000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723000472 putative substrate translocation pore; other site 369723000473 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 369723000474 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 369723000475 [4Fe-4S] binding site [ion binding]; other site 369723000476 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 369723000477 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 369723000478 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 369723000479 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 369723000480 molybdopterin cofactor binding site; other site 369723000481 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 369723000482 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 369723000483 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 369723000484 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 369723000485 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 369723000486 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 369723000487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723000488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723000489 S-adenosylmethionine binding site [chemical binding]; other site 369723000490 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 369723000491 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 369723000492 catalytic Zn binding site [ion binding]; other site 369723000493 NAD(P) binding site [chemical binding]; other site 369723000494 structural Zn binding site [ion binding]; other site 369723000495 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 369723000496 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 369723000497 catalytic Zn binding site [ion binding]; other site 369723000498 NAD(P) binding site [chemical binding]; other site 369723000499 structural Zn binding site [ion binding]; other site 369723000500 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 369723000501 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 369723000502 VanW like protein; Region: VanW; pfam04294 369723000503 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 369723000504 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 369723000505 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 369723000506 putative NADH binding site [chemical binding]; other site 369723000507 putative active site [active] 369723000508 nudix motif; other site 369723000509 putative metal binding site [ion binding]; other site 369723000510 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 369723000511 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 369723000512 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723000513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723000514 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 369723000515 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 369723000516 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 369723000517 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 369723000518 EamA-like transporter family; Region: EamA; pfam00892 369723000519 EamA-like transporter family; Region: EamA; pfam00892 369723000520 hypothetical protein; Provisional; Region: PRK07945 369723000521 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 369723000522 active site 369723000523 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 369723000524 Peptidase family M23; Region: Peptidase_M23; pfam01551 369723000525 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 369723000526 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 369723000527 nucleoside/Zn binding site; other site 369723000528 dimer interface [polypeptide binding]; other site 369723000529 catalytic motif [active] 369723000530 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 369723000531 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 369723000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723000533 S-adenosylmethionine binding site [chemical binding]; other site 369723000534 hypothetical protein; Provisional; Region: PRK11770 369723000535 Domain of unknown function (DUF307); Region: DUF307; pfam03733 369723000536 Domain of unknown function (DUF307); Region: DUF307; pfam03733 369723000537 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723000538 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 369723000539 active site 369723000540 substrate binding site [chemical binding]; other site 369723000541 ATP binding site [chemical binding]; other site 369723000542 Phosphotransferase enzyme family; Region: APH; pfam01636 369723000543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723000544 S-adenosylmethionine binding site [chemical binding]; other site 369723000545 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 369723000546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723000547 Walker A motif; other site 369723000548 ATP binding site [chemical binding]; other site 369723000549 Walker B motif; other site 369723000550 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 369723000551 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 369723000552 recombination protein RecR; Reviewed; Region: recR; PRK00076 369723000553 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 369723000554 RecR protein; Region: RecR; pfam02132 369723000555 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 369723000556 putative active site [active] 369723000557 putative metal-binding site [ion binding]; other site 369723000558 tetramer interface [polypeptide binding]; other site 369723000559 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 369723000560 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 369723000561 peptide binding site [polypeptide binding]; other site 369723000562 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723000564 dimer interface [polypeptide binding]; other site 369723000565 conserved gate region; other site 369723000566 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 369723000567 ABC-ATPase subunit interface; other site 369723000568 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 369723000569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 369723000570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723000571 putative PBP binding loops; other site 369723000572 dimer interface [polypeptide binding]; other site 369723000573 ABC-ATPase subunit interface; other site 369723000574 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 369723000575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723000576 Walker A/P-loop; other site 369723000577 ATP binding site [chemical binding]; other site 369723000578 Q-loop/lid; other site 369723000579 ABC transporter signature motif; other site 369723000580 Walker B; other site 369723000581 D-loop; other site 369723000582 H-loop/switch region; other site 369723000583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 369723000584 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 369723000585 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723000586 Walker A/P-loop; other site 369723000587 ATP binding site [chemical binding]; other site 369723000588 Q-loop/lid; other site 369723000589 ABC transporter signature motif; other site 369723000590 Walker B; other site 369723000591 D-loop; other site 369723000592 H-loop/switch region; other site 369723000593 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 369723000594 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 369723000595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723000596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723000597 putative substrate translocation pore; other site 369723000598 2-isopropylmalate synthase; Validated; Region: PRK03739 369723000599 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 369723000600 active site 369723000601 catalytic residues [active] 369723000602 metal binding site [ion binding]; metal-binding site 369723000603 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 369723000604 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723000605 FMN binding site [chemical binding]; other site 369723000606 dimer interface [polypeptide binding]; other site 369723000607 aspartate kinase; Reviewed; Region: PRK06635 369723000608 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 369723000609 putative nucleotide binding site [chemical binding]; other site 369723000610 putative catalytic residues [active] 369723000611 putative Mg ion binding site [ion binding]; other site 369723000612 putative aspartate binding site [chemical binding]; other site 369723000613 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 369723000614 putative allosteric regulatory site; other site 369723000615 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 369723000616 putative allosteric regulatory residue; other site 369723000617 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 369723000618 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 369723000619 GAF domain; Region: GAF_3; pfam13492 369723000620 GAF domain; Region: GAF_2; pfam13185 369723000621 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723000622 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723000623 metal binding site [ion binding]; metal-binding site 369723000624 active site 369723000625 I-site; other site 369723000626 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 369723000627 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 369723000628 putative active site [active] 369723000629 putative metal binding site [ion binding]; other site 369723000630 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 369723000631 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 369723000632 AAA domain; Region: AAA_30; pfam13604 369723000633 Family description; Region: UvrD_C_2; pfam13538 369723000634 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 369723000635 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 369723000636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723000637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723000638 DNA binding residues [nucleotide binding] 369723000639 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 369723000640 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 369723000641 Cupin domain; Region: Cupin_2; cl17218 369723000642 Predicted transcriptional regulator [Transcription]; Region: COG2345 369723000643 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 369723000644 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 369723000645 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 369723000646 active site 369723000647 homodimer interface [polypeptide binding]; other site 369723000648 enoyl-CoA hydratase; Provisional; Region: PRK06127 369723000649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723000650 substrate binding site [chemical binding]; other site 369723000651 oxyanion hole (OAH) forming residues; other site 369723000652 trimer interface [polypeptide binding]; other site 369723000653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723000654 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 369723000655 TrkA-N domain; Region: TrkA_N; pfam02254 369723000656 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 369723000657 TrkA-N domain; Region: TrkA_N; pfam02254 369723000658 TrkA-C domain; Region: TrkA_C; pfam02080 369723000659 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 369723000660 active site 369723000661 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 369723000662 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 369723000663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723000664 active site 369723000665 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 369723000666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723000667 nucleotide binding site [chemical binding]; other site 369723000668 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 369723000669 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 369723000670 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 369723000671 dimer interface [polypeptide binding]; other site 369723000672 active site 369723000673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 369723000674 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 369723000675 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 369723000676 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723000677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723000678 Walker A/P-loop; other site 369723000679 ATP binding site [chemical binding]; other site 369723000680 Q-loop/lid; other site 369723000681 ABC transporter signature motif; other site 369723000682 Walker B; other site 369723000683 D-loop; other site 369723000684 H-loop/switch region; other site 369723000685 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 369723000686 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 369723000687 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 369723000688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723000689 Walker A motif; other site 369723000690 ATP binding site [chemical binding]; other site 369723000691 Walker B motif; other site 369723000692 arginine finger; other site 369723000693 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723000694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723000695 S-adenosylmethionine binding site [chemical binding]; other site 369723000696 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723000697 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 369723000698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723000699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723000700 Walker A/P-loop; other site 369723000701 ATP binding site [chemical binding]; other site 369723000702 Q-loop/lid; other site 369723000703 ABC transporter signature motif; other site 369723000704 Walker B; other site 369723000705 D-loop; other site 369723000706 H-loop/switch region; other site 369723000707 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723000708 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723000709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723000710 DNA-binding site [nucleotide binding]; DNA binding site 369723000711 transcriptional regulator BetI; Validated; Region: PRK00767 369723000712 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 369723000713 Acyltransferase family; Region: Acyl_transf_3; pfam01757 369723000714 threonine synthase; Validated; Region: PRK07591 369723000715 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 369723000716 homodimer interface [polypeptide binding]; other site 369723000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723000718 catalytic residue [active] 369723000719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000720 Coenzyme A binding pocket [chemical binding]; other site 369723000721 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 369723000722 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723000723 NAD(P) binding site [chemical binding]; other site 369723000724 catalytic residues [active] 369723000725 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 369723000726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 369723000727 S-adenosylmethionine binding site [chemical binding]; other site 369723000728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000729 Coenzyme A binding pocket [chemical binding]; other site 369723000730 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723000731 DNA-binding site [nucleotide binding]; DNA binding site 369723000732 RNA-binding motif; other site 369723000733 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 369723000734 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 369723000735 ring oligomerisation interface [polypeptide binding]; other site 369723000736 ATP/Mg binding site [chemical binding]; other site 369723000737 stacking interactions; other site 369723000738 hinge regions; other site 369723000739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000740 Coenzyme A binding pocket [chemical binding]; other site 369723000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000742 Coenzyme A binding pocket [chemical binding]; other site 369723000743 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 369723000744 active site 369723000745 catalytic triad [active] 369723000746 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 369723000747 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723000748 FAD binding domain; Region: FAD_binding_4; pfam01565 369723000749 Predicted membrane protein [Function unknown]; Region: COG4129 369723000750 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 369723000751 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 369723000752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723000753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723000754 catalytic residue [active] 369723000755 Protease prsW family; Region: PrsW-protease; pfam13367 369723000756 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 369723000757 oligomerisation interface [polypeptide binding]; other site 369723000758 mobile loop; other site 369723000759 roof hairpin; other site 369723000760 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 369723000761 Domain of unknown function DUF20; Region: UPF0118; pfam01594 369723000762 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 369723000763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 369723000764 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 369723000765 Protein of unknown function (DUF402); Region: DUF402; cl00979 369723000766 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 369723000767 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 369723000768 NUDIX domain; Region: NUDIX; pfam00293 369723000769 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 369723000770 PhoU domain; Region: PhoU; pfam01895 369723000771 PBP superfamily domain; Region: PBP_like_2; cl17296 369723000772 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 369723000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723000774 dimer interface [polypeptide binding]; other site 369723000775 conserved gate region; other site 369723000776 putative PBP binding loops; other site 369723000777 ABC-ATPase subunit interface; other site 369723000778 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 369723000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723000780 dimer interface [polypeptide binding]; other site 369723000781 conserved gate region; other site 369723000782 putative PBP binding loops; other site 369723000783 ABC-ATPase subunit interface; other site 369723000784 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 369723000785 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 369723000786 Walker A/P-loop; other site 369723000787 ATP binding site [chemical binding]; other site 369723000788 Q-loop/lid; other site 369723000789 ABC transporter signature motif; other site 369723000790 Walker B; other site 369723000791 D-loop; other site 369723000792 H-loop/switch region; other site 369723000793 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 369723000794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723000795 DNA binding site [nucleotide binding] 369723000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000797 Coenzyme A binding pocket [chemical binding]; other site 369723000798 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 369723000799 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723000800 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 369723000801 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 369723000802 NodB motif; other site 369723000803 active site 369723000804 catalytic site [active] 369723000805 metal binding site [ion binding]; metal-binding site 369723000806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723000807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723000808 DNA binding site [nucleotide binding] 369723000809 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 369723000810 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 369723000811 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 369723000812 active site residue [active] 369723000813 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 369723000814 active site residue [active] 369723000815 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 369723000816 cell division protein GpsB; Provisional; Region: PRK14127 369723000817 Transcriptional regulators [Transcription]; Region: FadR; COG2186 369723000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723000819 DNA-binding site [nucleotide binding]; DNA binding site 369723000820 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723000821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723000822 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723000823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723000824 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723000825 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723000826 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723000827 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 369723000828 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 369723000829 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 369723000830 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 369723000831 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 369723000832 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 369723000833 protein-splicing catalytic site; other site 369723000834 thioester formation/cholesterol transfer; other site 369723000835 Pretoxin HINT domain; Region: PT-HINT; pfam07591 369723000836 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 369723000837 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 369723000838 active site 369723000839 catalytic triad [active] 369723000840 Cna protein B-type domain; Region: Cna_B_2; pfam13715 369723000841 Kelch domain; Region: Kelch; smart00612 369723000842 Kelch motif; Region: Kelch_1; pfam01344 369723000843 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 369723000844 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 369723000845 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 369723000846 DNA binding site [nucleotide binding] 369723000847 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 369723000848 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723000849 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 369723000850 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 369723000851 heme-binding site [chemical binding]; other site 369723000852 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 369723000853 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 369723000854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723000855 catalytic residue [active] 369723000856 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 369723000857 metal binding site 2 [ion binding]; metal-binding site 369723000858 putative DNA binding helix; other site 369723000859 metal binding site 1 [ion binding]; metal-binding site 369723000860 dimer interface [polypeptide binding]; other site 369723000861 structural Zn2+ binding site [ion binding]; other site 369723000862 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 369723000863 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 369723000864 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 369723000865 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 369723000866 L-asparaginase II; Region: Asparaginase_II; pfam06089 369723000867 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723000868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723000869 non-specific DNA binding site [nucleotide binding]; other site 369723000870 salt bridge; other site 369723000871 sequence-specific DNA binding site [nucleotide binding]; other site 369723000872 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 369723000873 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723000874 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 369723000875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723000876 Coenzyme A binding pocket [chemical binding]; other site 369723000877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723000878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 369723000879 homotrimer interaction site [polypeptide binding]; other site 369723000880 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723000881 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723000882 DNA binding site [nucleotide binding] 369723000883 domain linker motif; other site 369723000884 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 369723000885 putative dimerization interface [polypeptide binding]; other site 369723000886 putative ligand binding site [chemical binding]; other site 369723000887 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 369723000888 beta-galactosidase; Region: BGL; TIGR03356 369723000889 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723000890 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 369723000891 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 369723000892 FAD binding domain; Region: FAD_binding_4; pfam01565 369723000893 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 369723000894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 369723000895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723000896 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 369723000897 NAD(P) binding site [chemical binding]; other site 369723000898 active site 369723000899 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 369723000900 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 369723000901 putative ADP-binding pocket [chemical binding]; other site 369723000902 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 369723000903 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 369723000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723000905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723000906 putative substrate translocation pore; other site 369723000907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723000908 catalytic core [active] 369723000909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723000910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723000911 dimer interface [polypeptide binding]; other site 369723000912 phosphorylation site [posttranslational modification] 369723000913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723000914 ATP binding site [chemical binding]; other site 369723000915 Mg2+ binding site [ion binding]; other site 369723000916 G-X-G motif; other site 369723000917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723000918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723000919 active site 369723000920 phosphorylation site [posttranslational modification] 369723000921 intermolecular recognition site; other site 369723000922 dimerization interface [polypeptide binding]; other site 369723000923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723000924 DNA binding site [nucleotide binding] 369723000925 exopolyphosphatase; Region: exo_poly_only; TIGR03706 369723000926 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 369723000927 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 369723000928 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 369723000929 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 369723000930 CGNR zinc finger; Region: zf-CGNR; pfam11706 369723000931 Proline dehydrogenase; Region: Pro_dh; cl03282 369723000932 DNA binding domain, excisionase family; Region: excise; TIGR01764 369723000933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723000934 NAD(P) binding site [chemical binding]; other site 369723000935 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 369723000936 active site 369723000937 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723000938 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 369723000939 putative acyl-acceptor binding pocket; other site 369723000940 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723000941 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 369723000942 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 369723000943 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 369723000944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723000945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723000946 DNA binding residues [nucleotide binding] 369723000947 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 369723000948 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 369723000949 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 369723000950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723000951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 369723000952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723000953 dimerization interface [polypeptide binding]; other site 369723000954 DNA binding residues [nucleotide binding] 369723000955 Putative sensor; Region: Sensor; pfam13796 369723000956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723000957 Histidine kinase; Region: HisKA_3; pfam07730 369723000958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723000959 ATP binding site [chemical binding]; other site 369723000960 Mg2+ binding site [ion binding]; other site 369723000961 G-X-G motif; other site 369723000962 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 369723000963 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 369723000964 CoA binding domain; Region: CoA_binding; pfam02629 369723000965 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 369723000966 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 369723000967 tRNA; other site 369723000968 putative tRNA binding site [nucleotide binding]; other site 369723000969 putative NADP binding site [chemical binding]; other site 369723000970 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 369723000971 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 369723000972 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 369723000973 domain interfaces; other site 369723000974 active site 369723000975 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 369723000976 homodimer interface [polypeptide binding]; other site 369723000977 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 369723000978 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 369723000979 active site 369723000980 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 369723000981 dimer interface [polypeptide binding]; other site 369723000982 active site 369723000983 Schiff base residues; other site 369723000984 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 369723000985 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 369723000986 generic binding surface I; other site 369723000987 generic binding surface II; other site 369723000988 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 369723000989 putative catalytic site [active] 369723000990 putative phosphate binding site [ion binding]; other site 369723000991 putative metal binding site [ion binding]; other site 369723000992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723000993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 369723000994 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 369723000995 N-acetyl-D-glucosamine binding site [chemical binding]; other site 369723000996 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 369723000997 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 369723000998 cyclase homology domain; Region: CHD; cd07302 369723000999 nucleotidyl binding site; other site 369723001000 metal binding site [ion binding]; metal-binding site 369723001001 dimer interface [polypeptide binding]; other site 369723001002 Predicted ATPase [General function prediction only]; Region: COG3903 369723001003 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723001004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 369723001006 binding surface 369723001007 TPR motif; other site 369723001008 Smr domain; Region: Smr; pfam01713 369723001009 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 369723001010 Integrase core domain; Region: rve; pfam00665 369723001011 Inositol monophosphatase family; Region: Inositol_P; pfam00459 369723001012 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 369723001013 active site 369723001014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 369723001015 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 369723001016 TrkA-N domain; Region: TrkA_N; pfam02254 369723001017 TrkA-C domain; Region: TrkA_C; pfam02080 369723001018 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 369723001019 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 369723001020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723001021 classical (c) SDRs; Region: SDR_c; cd05233 369723001022 NAD(P) binding site [chemical binding]; other site 369723001023 active site 369723001024 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 369723001025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723001026 ATP binding site [chemical binding]; other site 369723001027 putative Mg++ binding site [ion binding]; other site 369723001028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723001029 nucleotide binding region [chemical binding]; other site 369723001030 ATP-binding site [chemical binding]; other site 369723001031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723001032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723001033 non-specific DNA binding site [nucleotide binding]; other site 369723001034 salt bridge; other site 369723001035 sequence-specific DNA binding site [nucleotide binding]; other site 369723001036 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723001037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001038 S-adenosylmethionine binding site [chemical binding]; other site 369723001039 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 369723001040 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 369723001041 ATP binding site [chemical binding]; other site 369723001042 Mg++ binding site [ion binding]; other site 369723001043 motif III; other site 369723001044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723001045 nucleotide binding region [chemical binding]; other site 369723001046 ATP-binding site [chemical binding]; other site 369723001047 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 369723001048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723001049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723001050 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 369723001051 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 369723001052 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 369723001053 ATP binding site [chemical binding]; other site 369723001054 substrate interface [chemical binding]; other site 369723001055 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 369723001056 active site residue [active] 369723001057 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 369723001058 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 369723001059 putative catalytic cysteine [active] 369723001060 gamma-glutamyl kinase; Provisional; Region: PRK05429 369723001061 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 369723001062 nucleotide binding site [chemical binding]; other site 369723001063 homotetrameric interface [polypeptide binding]; other site 369723001064 putative phosphate binding site [ion binding]; other site 369723001065 putative allosteric binding site; other site 369723001066 PUA domain; Region: PUA; pfam01472 369723001067 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 369723001068 active site 369723001069 DNA binding site [nucleotide binding] 369723001070 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 369723001071 MFS/sugar transport protein; Region: MFS_2; pfam13347 369723001072 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 369723001073 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 369723001074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723001075 catalytic residue [active] 369723001076 NADH dehydrogenase subunit B; Validated; Region: PRK06411 369723001077 Glucose dehydrogenase; Region: glucose_DH; cd08230 369723001078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 369723001079 NADP binding site [chemical binding]; other site 369723001080 catalytic Zn binding site [ion binding]; other site 369723001081 structural Zn binding site [ion binding]; other site 369723001082 dimer interface [polypeptide binding]; other site 369723001083 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 369723001084 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 369723001085 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 369723001086 Predicted permeases [General function prediction only]; Region: RarD; COG2962 369723001087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723001088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723001089 active site 369723001090 phosphorylation site [posttranslational modification] 369723001091 intermolecular recognition site; other site 369723001092 dimerization interface [polypeptide binding]; other site 369723001093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723001094 DNA binding residues [nucleotide binding] 369723001095 dimerization interface [polypeptide binding]; other site 369723001096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723001097 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 369723001098 Histidine kinase; Region: HisKA_3; pfam07730 369723001099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723001100 ATP binding site [chemical binding]; other site 369723001101 Mg2+ binding site [ion binding]; other site 369723001102 G-X-G motif; other site 369723001103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001104 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 369723001105 Walker A/P-loop; other site 369723001106 ATP binding site [chemical binding]; other site 369723001107 Q-loop/lid; other site 369723001108 ABC transporter signature motif; other site 369723001109 Walker B; other site 369723001110 D-loop; other site 369723001111 H-loop/switch region; other site 369723001112 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 369723001113 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723001114 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 369723001115 putative dimer interface [polypeptide binding]; other site 369723001116 N-terminal domain interface [polypeptide binding]; other site 369723001117 putative substrate binding pocket (H-site) [chemical binding]; other site 369723001118 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 369723001119 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 369723001120 4Fe-4S binding domain; Region: Fer4; pfam00037 369723001121 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 369723001122 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 369723001123 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 369723001124 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001125 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001126 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001127 heat shock protein HtpX; Provisional; Region: PRK03072 369723001128 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 369723001129 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 369723001130 classical (c) SDRs; Region: SDR_c; cd05233 369723001131 NAD(P) binding site [chemical binding]; other site 369723001132 active site 369723001133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 369723001134 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 369723001135 translocation protein TolB; Provisional; Region: tolB; PRK04922 369723001136 hypothetical protein; Provisional; Region: PRK08236 369723001137 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723001139 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 369723001140 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 369723001141 MarR family; Region: MarR_2; cl17246 369723001142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 369723001143 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723001145 putative substrate translocation pore; other site 369723001146 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 369723001147 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 369723001148 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 369723001149 phosphoserine aminotransferase; Provisional; Region: PRK03080 369723001150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723001151 catalytic residue [active] 369723001152 citrate synthase 2; Provisional; Region: PRK12350 369723001153 Citrate synthase; Region: Citrate_synt; pfam00285 369723001154 oxalacetate binding site [chemical binding]; other site 369723001155 citrylCoA binding site [chemical binding]; other site 369723001156 coenzyme A binding site [chemical binding]; other site 369723001157 catalytic triad [active] 369723001158 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 369723001159 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 369723001160 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 369723001161 enterobactin exporter EntS; Provisional; Region: PRK10489 369723001162 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 369723001163 active site 369723001164 catalytic residues [active] 369723001165 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723001166 FMN binding site [chemical binding]; other site 369723001167 dimer interface [polypeptide binding]; other site 369723001168 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 369723001169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723001170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723001171 active site 369723001172 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 369723001173 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 369723001174 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 369723001175 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 369723001176 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 369723001177 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 369723001178 Walker A/P-loop; other site 369723001179 ATP binding site [chemical binding]; other site 369723001180 Q-loop/lid; other site 369723001181 ABC transporter signature motif; other site 369723001182 Walker B; other site 369723001183 D-loop; other site 369723001184 H-loop/switch region; other site 369723001185 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723001186 putative glycosyl transferase; Provisional; Region: PRK10073 369723001187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723001188 active site 369723001189 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 369723001190 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 369723001191 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 369723001192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001193 Walker A/P-loop; other site 369723001194 ATP binding site [chemical binding]; other site 369723001195 Q-loop/lid; other site 369723001196 ABC transporter signature motif; other site 369723001197 Walker B; other site 369723001198 D-loop; other site 369723001199 H-loop/switch region; other site 369723001200 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 369723001201 CoenzymeA binding site [chemical binding]; other site 369723001202 subunit interaction site [polypeptide binding]; other site 369723001203 PHB binding site; other site 369723001204 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 369723001205 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 369723001206 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 369723001207 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 369723001208 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 369723001209 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 369723001210 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 369723001211 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 369723001212 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 369723001213 putative active site [active] 369723001214 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 369723001215 active site clefts [active] 369723001216 zinc binding site [ion binding]; other site 369723001217 dimer interface [polypeptide binding]; other site 369723001218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 369723001219 YibE/F-like protein; Region: YibE_F; pfam07907 369723001220 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 369723001221 putative homodimer interface [polypeptide binding]; other site 369723001222 putative homotetramer interface [polypeptide binding]; other site 369723001223 putative allosteric switch controlling residues; other site 369723001224 putative metal binding site [ion binding]; other site 369723001225 putative homodimer-homodimer interface [polypeptide binding]; other site 369723001226 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 369723001227 metal-binding site [ion binding] 369723001228 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 369723001229 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 369723001230 metal-binding site [ion binding] 369723001231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 369723001232 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 369723001233 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 369723001234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001235 S-adenosylmethionine binding site [chemical binding]; other site 369723001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001237 S-adenosylmethionine binding site [chemical binding]; other site 369723001238 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 369723001239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723001240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723001241 DNA binding residues [nucleotide binding] 369723001242 Putative zinc-finger; Region: zf-HC2; pfam13490 369723001243 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 369723001244 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 369723001245 Walker A/P-loop; other site 369723001246 ATP binding site [chemical binding]; other site 369723001247 Q-loop/lid; other site 369723001248 ABC transporter signature motif; other site 369723001249 Walker B; other site 369723001250 D-loop; other site 369723001251 H-loop/switch region; other site 369723001252 Cupin-like domain; Region: Cupin_8; pfam13621 369723001253 hypothetical protein; Provisional; Region: PRK07505 369723001254 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 369723001255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723001256 catalytic residue [active] 369723001257 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 369723001258 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 369723001259 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 369723001260 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 369723001261 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 369723001262 putative active site [active] 369723001263 putative catalytic site [active] 369723001264 proline aminopeptidase P II; Provisional; Region: PRK10879 369723001265 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 369723001266 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 369723001267 active site 369723001268 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 369723001269 Right handed beta helix region; Region: Beta_helix; pfam13229 369723001270 stage V sporulation protein K; Region: spore_V_K; TIGR02881 369723001271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723001272 Walker A motif; other site 369723001273 ATP binding site [chemical binding]; other site 369723001274 Walker B motif; other site 369723001275 arginine finger; other site 369723001276 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 369723001277 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 369723001278 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723001279 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 369723001280 active site 369723001281 catalytic residues [active] 369723001282 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 369723001283 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723001284 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 369723001285 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723001286 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723001287 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 369723001288 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 369723001289 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 369723001290 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 369723001291 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 369723001292 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723001293 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 369723001294 active site 369723001295 catalytic residues [active] 369723001296 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 369723001297 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 369723001298 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 369723001299 catalytic site [active] 369723001300 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 369723001301 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 369723001302 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 369723001303 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 369723001304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 369723001305 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723001306 Predicted ATPase [General function prediction only]; Region: COG3903 369723001307 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 369723001308 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 369723001309 glycerol kinase; Provisional; Region: glpK; PRK00047 369723001310 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 369723001311 N- and C-terminal domain interface [polypeptide binding]; other site 369723001312 active site 369723001313 MgATP binding site [chemical binding]; other site 369723001314 catalytic site [active] 369723001315 metal binding site [ion binding]; metal-binding site 369723001316 putative homotetramer interface [polypeptide binding]; other site 369723001317 glycerol binding site [chemical binding]; other site 369723001318 homodimer interface [polypeptide binding]; other site 369723001319 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 369723001320 amphipathic channel; other site 369723001321 Asn-Pro-Ala signature motifs; other site 369723001322 Transcriptional regulator [Transcription]; Region: IclR; COG1414 369723001323 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 369723001324 Bacterial transcriptional regulator; Region: IclR; pfam01614 369723001325 glycerol kinase; Provisional; Region: glpK; PRK00047 369723001326 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 369723001327 N- and C-terminal domain interface [polypeptide binding]; other site 369723001328 active site 369723001329 MgATP binding site [chemical binding]; other site 369723001330 catalytic site [active] 369723001331 metal binding site [ion binding]; metal-binding site 369723001332 putative homotetramer interface [polypeptide binding]; other site 369723001333 glycerol binding site [chemical binding]; other site 369723001334 homodimer interface [polypeptide binding]; other site 369723001335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723001336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723001337 active site 369723001338 catalytic tetrad [active] 369723001339 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 369723001340 Beta-lactamase; Region: Beta-lactamase; pfam00144 369723001341 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 369723001342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001343 Walker A/P-loop; other site 369723001344 ATP binding site [chemical binding]; other site 369723001345 Q-loop/lid; other site 369723001346 ABC transporter signature motif; other site 369723001347 Walker B; other site 369723001348 D-loop; other site 369723001349 H-loop/switch region; other site 369723001350 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 369723001351 DNA binding site [nucleotide binding] 369723001352 active site 369723001353 Int/Topo IB signature motif; other site 369723001354 catalytic residues [active] 369723001355 Homeodomain-like domain; Region: HTH_23; cl17451 369723001356 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 369723001357 active site 369723001358 ATP binding site [chemical binding]; other site 369723001359 Uncharacterized conserved protein [Function unknown]; Region: COG4278 369723001360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723001361 non-specific DNA binding site [nucleotide binding]; other site 369723001362 salt bridge; other site 369723001363 sequence-specific DNA binding site [nucleotide binding]; other site 369723001364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723001365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723001366 non-specific DNA binding site [nucleotide binding]; other site 369723001367 salt bridge; other site 369723001368 sequence-specific DNA binding site [nucleotide binding]; other site 369723001369 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723001370 RNase_H superfamily; Region: RNase_H_2; pfam13482 369723001371 active site 369723001372 substrate binding site [chemical binding]; other site 369723001373 catalytic site [active] 369723001374 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 369723001375 active site 369723001376 metal binding site [ion binding]; metal-binding site 369723001377 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 369723001378 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 369723001379 AAA domain; Region: AAA_25; pfam13481 369723001380 Walker A motif; other site 369723001381 ATP binding site [chemical binding]; other site 369723001382 Walker B motif; other site 369723001383 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 369723001384 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 369723001385 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 369723001386 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723001387 Interdomain contacts; other site 369723001388 Cytokine receptor motif; other site 369723001389 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723001390 Interdomain contacts; other site 369723001391 Cytokine receptor motif; other site 369723001392 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723001393 Interdomain contacts; other site 369723001394 Cytokine receptor motif; other site 369723001395 Phage-related protein [Function unknown]; Region: COG5412 369723001396 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 369723001397 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 369723001398 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 369723001399 DNA binding residues [nucleotide binding] 369723001400 Helix-turn-helix domain; Region: HTH_17; pfam12728 369723001401 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 369723001402 active site 369723001403 catalytic residues [active] 369723001404 DNA binding site [nucleotide binding] 369723001405 Int/Topo IB signature motif; other site 369723001406 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 369723001407 oligomer interface [polypeptide binding]; other site 369723001408 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 369723001409 putative active site [active] 369723001410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 369723001411 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 369723001412 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 369723001413 cofactor binding site; other site 369723001414 DNA binding site [nucleotide binding] 369723001415 substrate interaction site [chemical binding]; other site 369723001416 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 369723001417 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 369723001418 AIPR protein; Region: AIPR; pfam10592 369723001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723001420 ATP binding site [chemical binding]; other site 369723001421 Mg2+ binding site [ion binding]; other site 369723001422 G-X-G motif; other site 369723001423 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 369723001424 Z1 domain; Region: Z1; pfam10593 369723001425 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 369723001426 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 369723001427 selenophosphate synthetase; Provisional; Region: PRK00943 369723001428 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 369723001429 dimerization interface [polypeptide binding]; other site 369723001430 putative ATP binding site [chemical binding]; other site 369723001431 selenocysteine synthase; Provisional; Region: PRK04311 369723001432 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 369723001433 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723001434 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 369723001435 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 369723001436 G1 box; other site 369723001437 putative GEF interaction site [polypeptide binding]; other site 369723001438 GTP/Mg2+ binding site [chemical binding]; other site 369723001439 Switch I region; other site 369723001440 G2 box; other site 369723001441 G3 box; other site 369723001442 Switch II region; other site 369723001443 G4 box; other site 369723001444 G5 box; other site 369723001445 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 369723001446 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 369723001447 Transposase, Mutator family; Region: Transposase_mut; pfam00872 369723001448 MULE transposase domain; Region: MULE; pfam10551 369723001449 Transposase, Mutator family; Region: Transposase_mut; pfam00872 369723001450 Transposase, Mutator family; Region: Transposase_mut; pfam00872 369723001451 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723001452 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723001453 active site 369723001454 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723001455 FMN binding site [chemical binding]; other site 369723001456 dimer interface [polypeptide binding]; other site 369723001457 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 369723001458 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 369723001459 translocation protein TolB; Provisional; Region: tolB; PRK04922 369723001460 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 369723001461 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723001462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001463 S-adenosylmethionine binding site [chemical binding]; other site 369723001464 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 369723001465 Family description; Region: VCBS; pfam13517 369723001466 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 369723001467 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723001468 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723001469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723001470 active site 369723001471 Acyl transferase domain; Region: Acyl_transf_1; cl08282 369723001472 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 369723001473 putative NADP binding site [chemical binding]; other site 369723001474 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723001475 active site 369723001476 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723001477 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 369723001478 active site 369723001479 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 369723001480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723001481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723001482 HEAT repeats; Region: HEAT_2; pfam13646 369723001483 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 369723001484 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 369723001485 ABC1 family; Region: ABC1; cl17513 369723001486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723001487 Cytochrome P450; Region: p450; cl12078 369723001488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001489 S-adenosylmethionine binding site [chemical binding]; other site 369723001490 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723001491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723001492 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 369723001493 hydrophobic ligand binding site; other site 369723001494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723001495 putative DNA binding site [nucleotide binding]; other site 369723001496 dimerization interface [polypeptide binding]; other site 369723001497 putative Zn2+ binding site [ion binding]; other site 369723001498 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 369723001499 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 369723001500 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 369723001501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723001502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723001503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723001504 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 369723001505 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 369723001506 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 369723001507 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 369723001508 SnoaL-like domain; Region: SnoaL_3; pfam13474 369723001509 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 369723001510 active site 369723001511 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723001512 Transcriptional regulator PadR-like family; Region: PadR; cl17335 369723001513 Family description; Region: VCBS; pfam13517 369723001514 Family description; Region: VCBS; pfam13517 369723001515 Family description; Region: VCBS; pfam13517 369723001516 Family description; Region: VCBS; pfam13517 369723001517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001518 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 369723001519 Walker A/P-loop; other site 369723001520 ATP binding site [chemical binding]; other site 369723001521 Q-loop/lid; other site 369723001522 ABC transporter signature motif; other site 369723001523 Walker B; other site 369723001524 D-loop; other site 369723001525 H-loop/switch region; other site 369723001526 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 369723001527 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723001528 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 369723001529 Family description; Region: VCBS; pfam13517 369723001530 Family description; Region: VCBS; pfam13517 369723001531 Family description; Region: VCBS; pfam13517 369723001532 Family description; Region: VCBS; pfam13517 369723001533 Family description; Region: VCBS; pfam13517 369723001534 Family description; Region: VCBS; pfam13517 369723001535 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723001536 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723001537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723001538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723001539 dimerization interface [polypeptide binding]; other site 369723001540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723001541 dimer interface [polypeptide binding]; other site 369723001542 phosphorylation site [posttranslational modification] 369723001543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723001544 ATP binding site [chemical binding]; other site 369723001545 Mg2+ binding site [ion binding]; other site 369723001546 G-X-G motif; other site 369723001547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723001548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723001549 active site 369723001550 phosphorylation site [posttranslational modification] 369723001551 intermolecular recognition site; other site 369723001552 dimerization interface [polypeptide binding]; other site 369723001553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723001554 DNA binding site [nucleotide binding] 369723001555 BNR repeat-like domain; Region: BNR_2; pfam13088 369723001556 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 369723001557 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 369723001558 Multicopper oxidase; Region: Cu-oxidase; pfam00394 369723001559 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 369723001560 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723001561 DNA-binding site [nucleotide binding]; DNA binding site 369723001562 RNA-binding motif; other site 369723001563 YcxB-like protein; Region: YcxB; pfam14317 369723001564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723001565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723001566 putative substrate translocation pore; other site 369723001567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 369723001568 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 369723001569 amphipathic channel; other site 369723001570 Asn-Pro-Ala signature motifs; other site 369723001571 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 369723001572 Low molecular weight phosphatase family; Region: LMWPc; cd00115 369723001573 active site 369723001574 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 369723001575 Beta-lactamase; Region: Beta-lactamase; pfam00144 369723001576 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 369723001577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723001578 DNA-binding site [nucleotide binding]; DNA binding site 369723001579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723001580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723001581 homodimer interface [polypeptide binding]; other site 369723001582 catalytic residue [active] 369723001583 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 369723001584 EamA-like transporter family; Region: EamA; pfam00892 369723001585 hypothetical protein; Reviewed; Region: PRK09588 369723001586 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 369723001587 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 369723001588 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 369723001589 Phosphotransferase enzyme family; Region: APH; pfam01636 369723001590 active site 369723001591 substrate binding site [chemical binding]; other site 369723001592 ATP binding site [chemical binding]; other site 369723001593 Methyltransferase domain; Region: Methyltransf_11; pfam08241 369723001594 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723001595 Helix-turn-helix domain; Region: HTH_31; pfam13560 369723001596 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 369723001597 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 369723001598 NodB motif; other site 369723001599 putative active site [active] 369723001600 putative catalytic site [active] 369723001601 putative Zn binding site [ion binding]; other site 369723001602 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 369723001603 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 369723001604 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 369723001605 active site 369723001606 S-ribosylhomocysteinase; Provisional; Region: PRK02260 369723001607 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723001608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723001609 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723001610 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 369723001611 AsnC family; Region: AsnC_trans_reg; pfam01037 369723001612 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 369723001613 Strictosidine synthase; Region: Str_synth; pfam03088 369723001614 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 369723001615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723001616 NAD(P) binding site [chemical binding]; other site 369723001617 active site 369723001618 glucose-1-dehydrogenase; Provisional; Region: PRK08936 369723001619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723001620 NAD(P) binding site [chemical binding]; other site 369723001621 active site 369723001622 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 369723001623 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 369723001624 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723001625 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 369723001626 putative NAD(P) binding site [chemical binding]; other site 369723001627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723001628 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 369723001629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723001630 Uncharacterized conserved protein [Function unknown]; Region: COG1359 369723001631 Membrane transport protein; Region: Mem_trans; cl09117 369723001632 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 369723001633 homotrimer interaction site [polypeptide binding]; other site 369723001634 putative active site [active] 369723001635 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 369723001636 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723001637 AAA ATPase domain; Region: AAA_16; pfam13191 369723001638 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 369723001639 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723001640 acyl-activating enzyme (AAE) consensus motif; other site 369723001641 AMP binding site [chemical binding]; other site 369723001642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723001643 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723001644 putative substrate translocation pore; other site 369723001645 Condensation domain; Region: Condensation; pfam00668 369723001646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723001647 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723001648 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723001649 acyl-activating enzyme (AAE) consensus motif; other site 369723001650 AMP binding site [chemical binding]; other site 369723001651 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723001652 Thioesterase domain; Region: Thioesterase; pfam00975 369723001653 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 369723001654 classical (c) SDRs; Region: SDR_c; cd05233 369723001655 NAD(P) binding site [chemical binding]; other site 369723001656 active site 369723001657 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 369723001658 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 369723001659 putative catalytic cysteine [active] 369723001660 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 369723001661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723001662 catalytic residue [active] 369723001663 AMP-binding enzyme; Region: AMP-binding; pfam00501 369723001664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723001665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723001666 acyl-activating enzyme (AAE) consensus motif; other site 369723001667 acyl-activating enzyme (AAE) consensus motif; other site 369723001668 AMP binding site [chemical binding]; other site 369723001669 active site 369723001670 CoA binding site [chemical binding]; other site 369723001671 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 369723001672 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 369723001673 dimer interface [polypeptide binding]; other site 369723001674 active site 369723001675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 369723001676 catalytic residues [active] 369723001677 substrate binding site [chemical binding]; other site 369723001678 acyl carrier protein; Provisional; Region: PRK07081 369723001679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723001680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723001681 active site 369723001682 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723001683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723001684 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 369723001685 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723001686 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723001687 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 369723001688 acyl-activating enzyme (AAE) consensus motif; other site 369723001689 AMP binding site [chemical binding]; other site 369723001690 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723001691 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723001692 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723001693 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 369723001694 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 369723001695 argininosuccinate synthase; Provisional; Region: PRK13820 369723001696 ANP binding site [chemical binding]; other site 369723001697 Substrate Binding Site II [chemical binding]; other site 369723001698 Substrate Binding Site I [chemical binding]; other site 369723001699 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 369723001700 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 369723001701 active site 369723001702 substrate binding site [chemical binding]; other site 369723001703 cosubstrate binding site; other site 369723001704 catalytic site [active] 369723001705 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 369723001706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723001707 active site 369723001708 metal binding site [ion binding]; metal-binding site 369723001709 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 369723001710 Membrane transport protein; Region: Mem_trans; cl09117 369723001711 Clp protease; Region: CLP_protease; pfam00574 369723001712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 369723001713 oligomer interface [polypeptide binding]; other site 369723001714 active site residues [active] 369723001715 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723001716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723001717 sequence-specific DNA binding site [nucleotide binding]; other site 369723001718 salt bridge; other site 369723001719 Ion channel; Region: Ion_trans_2; pfam07885 369723001720 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 369723001721 TrkA-N domain; Region: TrkA_N; pfam02254 369723001722 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 369723001723 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 369723001724 TPP-binding site [chemical binding]; other site 369723001725 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 369723001726 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 369723001727 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 369723001728 dimer interface [polypeptide binding]; other site 369723001729 PYR/PP interface [polypeptide binding]; other site 369723001730 TPP binding site [chemical binding]; other site 369723001731 substrate binding site [chemical binding]; other site 369723001732 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 369723001733 dihydropteroate synthase; Region: DHPS; TIGR01496 369723001734 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 369723001735 substrate binding pocket [chemical binding]; other site 369723001736 dimer interface [polypeptide binding]; other site 369723001737 inhibitor binding site; inhibition site 369723001738 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723001739 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 369723001740 hydrophobic ligand binding site; other site 369723001741 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 369723001742 enoyl-CoA hydratase; Provisional; Region: PRK08140 369723001743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723001744 substrate binding site [chemical binding]; other site 369723001745 oxyanion hole (OAH) forming residues; other site 369723001746 trimer interface [polypeptide binding]; other site 369723001747 PaaX-like protein; Region: PaaX; pfam07848 369723001748 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 369723001749 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 369723001750 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 369723001751 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 369723001752 interface (dimer of trimers) [polypeptide binding]; other site 369723001753 Substrate-binding/catalytic site; other site 369723001754 Zn-binding sites [ion binding]; other site 369723001755 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 369723001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001757 S-adenosylmethionine binding site [chemical binding]; other site 369723001758 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 369723001759 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 369723001760 sec-independent translocase; Provisional; Region: PRK01371 369723001761 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 369723001762 Domain of unknown function DUF59; Region: DUF59; cl00941 369723001763 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 369723001764 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 369723001765 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 369723001766 MgtE intracellular N domain; Region: MgtE_N; smart00924 369723001767 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 369723001768 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 369723001769 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 369723001770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723001771 motif II; other site 369723001772 short chain dehydrogenase; Provisional; Region: PRK06197 369723001773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723001774 NAD(P) binding site [chemical binding]; other site 369723001775 active site 369723001776 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 369723001777 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 369723001778 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723001779 classical (c) SDRs; Region: SDR_c; cd05233 369723001780 NAD(P) binding site [chemical binding]; other site 369723001781 active site 369723001782 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 369723001783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723001784 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723001785 active site 369723001786 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 369723001787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723001788 Radical SAM superfamily; Region: Radical_SAM; pfam04055 369723001789 FeS/SAM binding site; other site 369723001790 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 369723001791 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723001792 catalytic residues [active] 369723001793 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 369723001794 putative active site [active] 369723001795 putative catalytic site [active] 369723001796 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 369723001797 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 369723001798 Bacterial PH domain; Region: DUF304; pfam03703 369723001799 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 369723001800 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 369723001801 active site 369723001802 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 369723001803 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 369723001804 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 369723001805 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 369723001806 metal binding site 2 [ion binding]; metal-binding site 369723001807 putative DNA binding helix; other site 369723001808 metal binding site 1 [ion binding]; metal-binding site 369723001809 dimer interface [polypeptide binding]; other site 369723001810 structural Zn2+ binding site [ion binding]; other site 369723001811 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 369723001812 putative metal binding site [ion binding]; other site 369723001813 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 369723001814 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 369723001815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723001816 dimerization interface [polypeptide binding]; other site 369723001817 GAF domain; Region: GAF; cl17456 369723001818 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723001819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723001820 metal binding site [ion binding]; metal-binding site 369723001821 active site 369723001822 I-site; other site 369723001823 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 369723001824 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 369723001825 active site 369723001826 tetramer interface; other site 369723001827 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 369723001828 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 369723001829 dimer interface [polypeptide binding]; other site 369723001830 putative functional site; other site 369723001831 putative MPT binding site; other site 369723001832 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 369723001833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723001834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723001835 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 369723001836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001838 Walker A/P-loop; other site 369723001839 ATP binding site [chemical binding]; other site 369723001840 Q-loop/lid; other site 369723001841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001842 ABC transporter signature motif; other site 369723001843 Walker B; other site 369723001844 D-loop; other site 369723001845 ABC transporter; Region: ABC_tran_2; pfam12848 369723001846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001848 Walker A/P-loop; other site 369723001849 ATP binding site [chemical binding]; other site 369723001850 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 369723001851 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 369723001852 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 369723001853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723001854 motif II; other site 369723001855 Protein of unknown function (DUF664); Region: DUF664; pfam04978 369723001856 DinB superfamily; Region: DinB_2; pfam12867 369723001857 Nitrate and nitrite sensing; Region: NIT; pfam08376 369723001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723001859 ATP binding site [chemical binding]; other site 369723001860 Mg2+ binding site [ion binding]; other site 369723001861 G-X-G motif; other site 369723001862 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 369723001863 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 369723001864 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 369723001865 putative ligand binding site [chemical binding]; other site 369723001866 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723001867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723001868 S-adenosylmethionine binding site [chemical binding]; other site 369723001869 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 369723001870 TM-ABC transporter signature motif; other site 369723001871 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 369723001872 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 369723001873 TM-ABC transporter signature motif; other site 369723001874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 369723001875 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 369723001876 Walker A/P-loop; other site 369723001877 ATP binding site [chemical binding]; other site 369723001878 Q-loop/lid; other site 369723001879 ABC transporter signature motif; other site 369723001880 Walker B; other site 369723001881 D-loop; other site 369723001882 H-loop/switch region; other site 369723001883 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 369723001884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723001885 Walker A/P-loop; other site 369723001886 ATP binding site [chemical binding]; other site 369723001887 Q-loop/lid; other site 369723001888 ABC transporter signature motif; other site 369723001889 Walker B; other site 369723001890 D-loop; other site 369723001891 H-loop/switch region; other site 369723001892 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 369723001893 Lipase (class 2); Region: Lipase_2; pfam01674 369723001894 PhoD-like phosphatase; Region: PhoD; pfam09423 369723001895 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723001896 putative active site [active] 369723001897 putative metal binding site [ion binding]; other site 369723001898 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723001899 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 369723001900 NADH dehydrogenase; Region: NADHdh; cl00469 369723001901 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001902 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 369723001903 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001904 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723001905 enoyl-CoA hydratase; Provisional; Region: PRK05862 369723001906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723001907 substrate binding site [chemical binding]; other site 369723001908 oxyanion hole (OAH) forming residues; other site 369723001909 trimer interface [polypeptide binding]; other site 369723001910 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 369723001911 FAD binding pocket [chemical binding]; other site 369723001912 conserved FAD binding motif [chemical binding]; other site 369723001913 phosphate binding motif [ion binding]; other site 369723001914 beta-alpha-beta structure motif; other site 369723001915 NAD binding pocket [chemical binding]; other site 369723001916 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 369723001917 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723001918 acyl-activating enzyme (AAE) consensus motif; other site 369723001919 AMP binding site [chemical binding]; other site 369723001920 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 369723001921 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 369723001922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 369723001923 Predicted methyltransferases [General function prediction only]; Region: COG0313 369723001924 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 369723001925 putative SAM binding site [chemical binding]; other site 369723001926 putative homodimer interface [polypeptide binding]; other site 369723001927 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 369723001928 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 369723001929 active site 369723001930 HIGH motif; other site 369723001931 KMSKS motif; other site 369723001932 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 369723001933 tRNA binding surface [nucleotide binding]; other site 369723001934 anticodon binding site; other site 369723001935 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 369723001936 active site 369723001937 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 369723001938 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 369723001939 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 369723001940 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 369723001941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001943 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723001944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723001945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723001946 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 369723001947 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 369723001948 Substrate binding site; other site 369723001949 Mg++ binding site; other site 369723001950 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 369723001951 active site 369723001952 substrate binding site [chemical binding]; other site 369723001953 CoA binding site [chemical binding]; other site 369723001954 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 369723001955 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 369723001956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723001957 active site 369723001958 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 369723001959 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 369723001960 5S rRNA interface [nucleotide binding]; other site 369723001961 CTC domain interface [polypeptide binding]; other site 369723001962 L16 interface [polypeptide binding]; other site 369723001963 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 369723001964 putative active site [active] 369723001965 catalytic residue [active] 369723001966 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 369723001967 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 369723001968 active site 369723001969 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 369723001970 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 369723001971 Active Sites [active] 369723001972 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 369723001973 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 369723001974 CysD dimerization site [polypeptide binding]; other site 369723001975 G1 box; other site 369723001976 putative GEF interaction site [polypeptide binding]; other site 369723001977 GTP/Mg2+ binding site [chemical binding]; other site 369723001978 Switch I region; other site 369723001979 G2 box; other site 369723001980 G3 box; other site 369723001981 Switch II region; other site 369723001982 G4 box; other site 369723001983 G5 box; other site 369723001984 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 369723001985 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 369723001986 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 369723001987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723001988 NAD(P) binding site [chemical binding]; other site 369723001989 active site 369723001990 FOG: CBS domain [General function prediction only]; Region: COG0517 369723001991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 369723001992 Transporter associated domain; Region: CorC_HlyC; smart01091 369723001993 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 369723001994 active site 369723001995 HIGH motif; other site 369723001996 dimer interface [polypeptide binding]; other site 369723001997 KMSKS motif; other site 369723001998 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 369723001999 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 369723002000 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 369723002001 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 369723002002 active site 369723002003 catalytic site [active] 369723002004 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 369723002005 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723002006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723002007 DNA binding site [nucleotide binding] 369723002008 domain linker motif; other site 369723002009 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 369723002010 putative dimerization interface [polypeptide binding]; other site 369723002011 putative ligand binding site [chemical binding]; other site 369723002012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723002013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 369723002014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723002015 dimer interface [polypeptide binding]; other site 369723002016 conserved gate region; other site 369723002017 putative PBP binding loops; other site 369723002018 ABC-ATPase subunit interface; other site 369723002019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723002020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723002021 dimer interface [polypeptide binding]; other site 369723002022 conserved gate region; other site 369723002023 putative PBP binding loops; other site 369723002024 ABC-ATPase subunit interface; other site 369723002025 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 369723002026 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 369723002027 ligand binding site [chemical binding]; other site 369723002028 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 369723002029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 369723002030 Walker A/P-loop; other site 369723002031 ATP binding site [chemical binding]; other site 369723002032 Q-loop/lid; other site 369723002033 ABC transporter signature motif; other site 369723002034 Walker B; other site 369723002035 D-loop; other site 369723002036 H-loop/switch region; other site 369723002037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 369723002038 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723002039 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 369723002040 TM-ABC transporter signature motif; other site 369723002041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723002042 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 369723002043 TM-ABC transporter signature motif; other site 369723002044 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 369723002045 active site 369723002046 catalytic motif [active] 369723002047 Zn binding site [ion binding]; other site 369723002048 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 369723002049 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 369723002050 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 369723002051 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 369723002052 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 369723002053 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 369723002054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002055 S-adenosylmethionine binding site [chemical binding]; other site 369723002056 adenosine deaminase; Provisional; Region: PRK09358 369723002057 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 369723002058 active site 369723002059 Nitrate and nitrite sensing; Region: NIT; pfam08376 369723002060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723002061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723002062 ATP binding site [chemical binding]; other site 369723002063 Mg2+ binding site [ion binding]; other site 369723002064 G-X-G motif; other site 369723002065 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 369723002066 Protein of unknown function (DUF742); Region: DUF742; pfam05331 369723002067 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 369723002068 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 369723002069 G1 box; other site 369723002070 GTP/Mg2+ binding site [chemical binding]; other site 369723002071 G2 box; other site 369723002072 Switch I region; other site 369723002073 G3 box; other site 369723002074 Switch II region; other site 369723002075 G4 box; other site 369723002076 G5 box; other site 369723002077 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 369723002078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723002079 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 369723002080 Walker A/P-loop; other site 369723002081 ATP binding site [chemical binding]; other site 369723002082 Q-loop/lid; other site 369723002083 ABC transporter signature motif; other site 369723002084 Walker B; other site 369723002085 D-loop; other site 369723002086 H-loop/switch region; other site 369723002087 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 369723002088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723002089 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 369723002090 Walker A/P-loop; other site 369723002091 ATP binding site [chemical binding]; other site 369723002092 Q-loop/lid; other site 369723002093 ABC transporter signature motif; other site 369723002094 Walker B; other site 369723002095 D-loop; other site 369723002096 H-loop/switch region; other site 369723002097 Penicillinase repressor; Region: Pencillinase_R; pfam03965 369723002098 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723002099 NAD(P) binding site [chemical binding]; other site 369723002100 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 369723002101 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723002102 NAD(P) binding site [chemical binding]; other site 369723002103 catalytic residues [active] 369723002104 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 369723002105 intersubunit interface [polypeptide binding]; other site 369723002106 active site 369723002107 catalytic residue [active] 369723002108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723002109 active site 369723002110 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 369723002111 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 369723002112 active site 369723002113 substrate binding site [chemical binding]; other site 369723002114 metal binding site [ion binding]; metal-binding site 369723002115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723002116 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 369723002117 active site 369723002118 ATP binding site [chemical binding]; other site 369723002119 substrate binding site [chemical binding]; other site 369723002120 activation loop (A-loop); other site 369723002121 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 369723002122 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 369723002123 amidohydrolase; Region: amidohydrolases; TIGR01891 369723002124 metal binding site [ion binding]; metal-binding site 369723002125 putative dimer interface [polypeptide binding]; other site 369723002126 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723002127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 369723002128 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 369723002129 putative active site pocket [active] 369723002130 dimerization interface [polypeptide binding]; other site 369723002131 putative catalytic residue [active] 369723002132 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 369723002133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723002134 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 369723002135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 369723002136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002137 Coenzyme A binding pocket [chemical binding]; other site 369723002138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723002139 non-specific DNA binding site [nucleotide binding]; other site 369723002140 salt bridge; other site 369723002141 sequence-specific DNA binding site [nucleotide binding]; other site 369723002142 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723002143 motif 1; other site 369723002144 dimer interface [polypeptide binding]; other site 369723002145 active site 369723002146 motif 2; other site 369723002147 motif 3; other site 369723002148 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 369723002149 anticodon binding site; other site 369723002150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723002151 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 369723002152 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723002153 Walker A/P-loop; other site 369723002154 ATP binding site [chemical binding]; other site 369723002155 Q-loop/lid; other site 369723002156 ABC transporter signature motif; other site 369723002157 Walker B; other site 369723002158 D-loop; other site 369723002159 H-loop/switch region; other site 369723002160 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723002161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723002162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723002163 Walker A/P-loop; other site 369723002164 ATP binding site [chemical binding]; other site 369723002165 Q-loop/lid; other site 369723002166 ABC transporter signature motif; other site 369723002167 Walker B; other site 369723002168 D-loop; other site 369723002169 H-loop/switch region; other site 369723002170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723002171 WHG domain; Region: WHG; pfam13305 369723002172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 369723002173 MarR family; Region: MarR; pfam01047 369723002174 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723002176 putative substrate translocation pore; other site 369723002177 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 369723002178 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 369723002179 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 369723002180 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 369723002181 active site 369723002182 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 369723002183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723002184 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 369723002185 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 369723002186 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 369723002187 carboxyltransferase (CT) interaction site; other site 369723002188 biotinylation site [posttranslational modification]; other site 369723002189 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 369723002190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002191 S-adenosylmethionine binding site [chemical binding]; other site 369723002192 Maf-like protein; Reviewed; Region: PRK00078 369723002193 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 369723002194 active site 369723002195 dimer interface [polypeptide binding]; other site 369723002196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723002197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 369723002198 active site 369723002199 ATP binding site [chemical binding]; other site 369723002200 substrate binding site [chemical binding]; other site 369723002201 activation loop (A-loop); other site 369723002202 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 369723002203 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 369723002204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723002205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723002206 DNA binding residues [nucleotide binding] 369723002207 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 369723002208 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 369723002209 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 369723002210 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 369723002211 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 369723002212 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 369723002213 Bacterial PH domain; Region: DUF304; pfam03703 369723002214 Predicted membrane protein [Function unknown]; Region: COG2246 369723002215 GtrA-like protein; Region: GtrA; pfam04138 369723002216 Predicted membrane protein [Function unknown]; Region: COG2246 369723002217 GtrA-like protein; Region: GtrA; pfam04138 369723002218 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 369723002219 active site 369723002220 substrate-binding site [chemical binding]; other site 369723002221 metal-binding site [ion binding] 369723002222 GTP binding site [chemical binding]; other site 369723002223 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 369723002224 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 369723002225 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 369723002226 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 369723002227 catalytic residue [active] 369723002228 putative FPP diphosphate binding site; other site 369723002229 putative FPP binding hydrophobic cleft; other site 369723002230 dimer interface [polypeptide binding]; other site 369723002231 putative IPP diphosphate binding site; other site 369723002232 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 369723002233 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 369723002234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723002235 non-specific DNA binding site [nucleotide binding]; other site 369723002236 salt bridge; other site 369723002237 sequence-specific DNA binding site [nucleotide binding]; other site 369723002238 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 369723002239 N-acetyl-D-glucosamine binding site [chemical binding]; other site 369723002240 catalytic residue [active] 369723002241 Rhomboid family; Region: Rhomboid; pfam01694 369723002242 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723002243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723002244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723002245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723002246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723002248 NAD(P) binding site [chemical binding]; other site 369723002249 active site 369723002250 Protein of unknown function, DUF606; Region: DUF606; pfam04657 369723002251 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 369723002252 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 369723002253 putative active site [active] 369723002254 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 369723002255 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 369723002256 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 369723002257 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 369723002258 generic binding surface II; other site 369723002259 generic binding surface I; other site 369723002260 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 369723002261 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 369723002262 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 369723002263 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 369723002264 active site 369723002265 catalytic residues [active] 369723002266 RmuC family; Region: RmuC; pfam02646 369723002267 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 369723002268 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 369723002269 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 369723002270 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 369723002271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723002272 ATP binding site [chemical binding]; other site 369723002273 putative Mg++ binding site [ion binding]; other site 369723002274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723002275 nucleotide binding region [chemical binding]; other site 369723002276 ATP-binding site [chemical binding]; other site 369723002277 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 369723002278 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 369723002279 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 369723002280 homodimer interface [polypeptide binding]; other site 369723002281 metal binding site [ion binding]; metal-binding site 369723002282 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 369723002283 enolase; Provisional; Region: eno; PRK00077 369723002284 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 369723002285 dimer interface [polypeptide binding]; other site 369723002286 metal binding site [ion binding]; metal-binding site 369723002287 substrate binding pocket [chemical binding]; other site 369723002288 Septum formation initiator; Region: DivIC; cl17659 369723002289 Protein of unknown function (DUF501); Region: DUF501; pfam04417 369723002290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002291 Coenzyme A binding pocket [chemical binding]; other site 369723002292 exopolyphosphatase; Region: exo_poly_only; TIGR03706 369723002293 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 369723002294 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723002295 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 369723002296 Predicted membrane protein [Function unknown]; Region: COG4709 369723002297 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 369723002298 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 369723002299 Fe-S cluster binding site [ion binding]; other site 369723002300 DNA binding site [nucleotide binding] 369723002301 active site 369723002302 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 369723002303 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723002304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723002305 Walker A motif; other site 369723002306 ATP binding site [chemical binding]; other site 369723002307 Walker B motif; other site 369723002308 arginine finger; other site 369723002309 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 369723002310 Protein of unknown function DUF58; Region: DUF58; pfam01882 369723002311 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 369723002312 Protein of unknown function (DUF1188); Region: DUF1188; cl01642 369723002313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723002314 Bax inhibitor 1 like; Region: BaxI_1; cl17691 369723002315 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 369723002316 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723002317 dimer interface [polypeptide binding]; other site 369723002318 active site 369723002319 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 369723002320 active site 369723002321 catalytic triad [active] 369723002322 oxyanion hole [active] 369723002323 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 369723002324 active site 369723002325 catalytic triad [active] 369723002326 oxyanion hole [active] 369723002327 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 369723002328 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 369723002329 dimer interface [polypeptide binding]; other site 369723002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002331 catalytic residue [active] 369723002332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 369723002333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002334 Coenzyme A binding pocket [chemical binding]; other site 369723002335 ribonuclease Z; Reviewed; Region: PRK00055 369723002336 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 369723002337 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 369723002338 putative oligomer interface [polypeptide binding]; other site 369723002339 putative active site [active] 369723002340 metal binding site [ion binding]; metal-binding site 369723002341 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 369723002342 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723002343 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723002344 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 369723002345 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 369723002346 active site 369723002347 dimer interface [polypeptide binding]; other site 369723002348 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 369723002349 Ligand Binding Site [chemical binding]; other site 369723002350 Molecular Tunnel; other site 369723002351 methionine sulfoxide reductase A; Provisional; Region: PRK00058 369723002352 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 369723002353 nucleotide binding site/active site [active] 369723002354 HIT family signature motif; other site 369723002355 catalytic residue [active] 369723002356 cystathionine gamma-synthase; Provisional; Region: PRK07811 369723002357 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 369723002358 homodimer interface [polypeptide binding]; other site 369723002359 substrate-cofactor binding pocket; other site 369723002360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002361 catalytic residue [active] 369723002362 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 369723002363 Amidase; Region: Amidase; cl11426 369723002364 threonine dehydratase; Provisional; Region: PRK08198 369723002365 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 369723002366 tetramer interface [polypeptide binding]; other site 369723002367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002368 catalytic residue [active] 369723002369 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 369723002370 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 369723002371 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 369723002372 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 369723002373 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 369723002374 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 369723002375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723002376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723002377 metal binding site [ion binding]; metal-binding site 369723002378 active site 369723002379 I-site; other site 369723002380 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723002381 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 369723002382 B3/4 domain; Region: B3_4; pfam03483 369723002383 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 369723002384 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 369723002385 catalytic residues [active] 369723002386 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 369723002387 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 369723002388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723002389 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 369723002390 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 369723002391 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 369723002392 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723002393 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 369723002394 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 369723002395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723002396 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723002397 active site 369723002398 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 369723002399 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 369723002400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723002401 acyl-activating enzyme (AAE) consensus motif; other site 369723002402 AMP binding site [chemical binding]; other site 369723002403 active site 369723002404 CoA binding site [chemical binding]; other site 369723002405 TIGR03089 family protein; Region: TIGR03089 369723002406 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 369723002407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723002408 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 369723002409 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 369723002410 Substrate binding site; other site 369723002411 Cupin domain; Region: Cupin_2; cl17218 369723002412 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 369723002413 nudix motif; other site 369723002414 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 369723002415 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 369723002416 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 369723002417 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 369723002418 phosphate binding site [ion binding]; other site 369723002419 dimer interface [polypeptide binding]; other site 369723002420 FO synthase; Reviewed; Region: fbiC; PRK09234 369723002421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723002422 FeS/SAM binding site; other site 369723002423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723002424 FeS/SAM binding site; other site 369723002425 Transcription factor WhiB; Region: Whib; pfam02467 369723002426 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 369723002427 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 369723002428 hypothetical protein; Provisional; Region: PRK06541 369723002429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723002430 inhibitor-cofactor binding pocket; inhibition site 369723002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002432 catalytic residue [active] 369723002433 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 369723002434 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 369723002435 AsnC family; Region: AsnC_trans_reg; pfam01037 369723002436 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723002437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002438 S-adenosylmethionine binding site [chemical binding]; other site 369723002439 AAA domain; Region: AAA_33; pfam13671 369723002440 AAA domain; Region: AAA_17; pfam13207 369723002441 Protein of unknown function (DUF779); Region: DUF779; pfam05610 369723002442 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723002443 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723002444 NAD(P) binding site [chemical binding]; other site 369723002445 catalytic residues [active] 369723002446 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 369723002447 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723002448 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723002449 NAD(P) binding site [chemical binding]; other site 369723002450 catalytic residues [active] 369723002451 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 369723002452 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 369723002453 active site 369723002454 substrate binding site [chemical binding]; other site 369723002455 metal binding site [ion binding]; metal-binding site 369723002456 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 369723002457 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 369723002458 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 369723002459 dimer interface [polypeptide binding]; other site 369723002460 active site 369723002461 Cation efflux family; Region: Cation_efflux; pfam01545 369723002462 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 369723002463 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 369723002464 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 369723002465 Adenosylhomocysteinase; Provisional; Region: PTZ00075 369723002466 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 369723002467 homotetramer interface [polypeptide binding]; other site 369723002468 ligand binding site [chemical binding]; other site 369723002469 catalytic site [active] 369723002470 NAD binding site [chemical binding]; other site 369723002471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723002472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723002473 active site 369723002474 phosphorylation site [posttranslational modification] 369723002475 intermolecular recognition site; other site 369723002476 dimerization interface [polypeptide binding]; other site 369723002477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723002478 DNA binding site [nucleotide binding] 369723002479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723002480 dimerization interface [polypeptide binding]; other site 369723002481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723002482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723002483 dimer interface [polypeptide binding]; other site 369723002484 phosphorylation site [posttranslational modification] 369723002485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723002486 ATP binding site [chemical binding]; other site 369723002487 Mg2+ binding site [ion binding]; other site 369723002488 G-X-G motif; other site 369723002489 Sporulation and spore germination; Region: Germane; pfam10646 369723002490 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 369723002491 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 369723002492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723002493 active site 369723002494 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 369723002495 30S subunit binding site; other site 369723002496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 369723002497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002498 Coenzyme A binding pocket [chemical binding]; other site 369723002499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723002500 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723002501 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 369723002502 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 369723002503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 369723002504 nucleotide binding region [chemical binding]; other site 369723002505 SEC-C motif; Region: SEC-C; pfam02810 369723002506 Helix-turn-helix domain; Region: HTH_17; pfam12728 369723002507 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723002508 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 369723002509 NAD(P) binding site [chemical binding]; other site 369723002510 catalytic residues [active] 369723002511 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723002512 Transcriptional regulator PadR-like family; Region: PadR; cl17335 369723002513 peptide chain release factor 2; Validated; Region: prfB; PRK00578 369723002514 This domain is found in peptide chain release factors; Region: PCRF; smart00937 369723002515 RF-1 domain; Region: RF-1; pfam00472 369723002516 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 369723002517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723002518 Walker A/P-loop; other site 369723002519 ATP binding site [chemical binding]; other site 369723002520 Q-loop/lid; other site 369723002521 ABC transporter signature motif; other site 369723002522 Walker B; other site 369723002523 D-loop; other site 369723002524 H-loop/switch region; other site 369723002525 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 369723002526 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 369723002527 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 369723002528 SmpB-tmRNA interface; other site 369723002529 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 369723002530 hypothetical protein; Validated; Region: PRK00228 369723002531 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 369723002532 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 369723002533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723002534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723002535 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723002536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723002537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002538 S-adenosylmethionine binding site [chemical binding]; other site 369723002539 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 369723002540 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723002541 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 369723002542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 369723002543 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 369723002544 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 369723002545 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723002546 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 369723002547 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 369723002548 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 369723002549 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 369723002550 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 369723002551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 369723002552 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 369723002553 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 369723002554 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 369723002555 CRISPR-associated protein; Region: TIGR03986 369723002556 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 369723002557 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 369723002558 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 369723002559 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 369723002560 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 369723002561 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 369723002562 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 369723002563 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 369723002564 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723002565 DNA binding residues [nucleotide binding] 369723002566 Methyltransferase domain; Region: Methyltransf_11; pfam08241 369723002567 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 369723002568 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 369723002569 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 369723002570 active site 369723002571 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 369723002572 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723002573 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 369723002574 NAD(P) binding site [chemical binding]; other site 369723002575 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723002576 MbtH-like protein; Region: MbtH; pfam03621 369723002577 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723002578 Cytochrome P450; Region: p450; cl12078 369723002579 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723002580 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723002581 active site 369723002582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723002583 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723002584 acyl-activating enzyme (AAE) consensus motif; other site 369723002585 AMP binding site [chemical binding]; other site 369723002586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723002587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723002588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723002589 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723002590 active site 369723002591 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723002592 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723002593 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723002594 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723002595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723002596 Condensation domain; Region: Condensation; pfam00668 369723002597 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723002598 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723002599 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 369723002600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723002601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723002602 NAD(P) binding site [chemical binding]; other site 369723002603 active site 369723002604 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723002605 YmdB-like protein; Region: YmdB; pfam13277 369723002606 active site 369723002607 metal binding site [ion binding]; metal-binding site 369723002608 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 369723002609 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723002610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723002611 DNA binding residues [nucleotide binding] 369723002612 dimerization interface [polypeptide binding]; other site 369723002613 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 369723002614 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 369723002615 dimer interface [polypeptide binding]; other site 369723002616 PYR/PP interface [polypeptide binding]; other site 369723002617 TPP binding site [chemical binding]; other site 369723002618 substrate binding site [chemical binding]; other site 369723002619 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 369723002620 TPP-binding site [chemical binding]; other site 369723002621 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 369723002622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723002623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723002624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 369723002625 dimerization interface [polypeptide binding]; other site 369723002626 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 369723002627 putative active site [active] 369723002628 putative catalytic site [active] 369723002629 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 369723002630 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 369723002631 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 369723002632 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 369723002633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723002634 acyl-activating enzyme (AAE) consensus motif; other site 369723002635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723002636 CoA binding site [chemical binding]; other site 369723002637 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 369723002638 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 369723002639 homodimer interface [polypeptide binding]; other site 369723002640 substrate-cofactor binding pocket; other site 369723002641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002642 catalytic residue [active] 369723002643 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 369723002644 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 369723002645 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 369723002646 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 369723002647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723002648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723002649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 369723002650 dimerization interface [polypeptide binding]; other site 369723002651 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 369723002652 DinB superfamily; Region: DinB_2; pfam12867 369723002653 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 369723002654 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 369723002655 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 369723002656 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 369723002657 protein-splicing catalytic site; other site 369723002658 thioester formation/cholesterol transfer; other site 369723002659 Pretoxin HINT domain; Region: PT-HINT; pfam07591 369723002660 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 369723002661 active site 369723002662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723002663 non-specific DNA binding site [nucleotide binding]; other site 369723002664 salt bridge; other site 369723002665 sequence-specific DNA binding site [nucleotide binding]; other site 369723002666 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 369723002667 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723002668 DNA binding residues [nucleotide binding] 369723002669 putative dimer interface [polypeptide binding]; other site 369723002670 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 369723002671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723002672 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723002673 Epoxide hydrolase N terminus; Region: EHN; pfam06441 369723002674 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723002675 HTH domain; Region: HTH_11; pfam08279 369723002676 WYL domain; Region: WYL; pfam13280 369723002677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002678 Coenzyme A binding pocket [chemical binding]; other site 369723002679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723002681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723002682 active site 369723002683 catalytic tetrad [active] 369723002684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002685 Coenzyme A binding pocket [chemical binding]; other site 369723002686 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 369723002687 Ricin-type beta-trefoil; Region: RICIN; smart00458 369723002688 putative sugar binding sites [chemical binding]; other site 369723002689 Q-X-W motif; other site 369723002690 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 369723002691 putative sugar binding sites [chemical binding]; other site 369723002692 Q-X-W motif; other site 369723002693 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723002694 FAD binding domain; Region: FAD_binding_4; pfam01565 369723002695 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 369723002696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002697 S-adenosylmethionine binding site [chemical binding]; other site 369723002698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723002699 putative substrate translocation pore; other site 369723002700 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 369723002701 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723002702 DNA binding residues [nucleotide binding] 369723002703 dimer interface [polypeptide binding]; other site 369723002704 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 369723002705 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 369723002706 GYD domain; Region: GYD; pfam08734 369723002707 RibD C-terminal domain; Region: RibD_C; cl17279 369723002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723002709 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723002710 putative substrate translocation pore; other site 369723002711 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 369723002712 NADH(P)-binding; Region: NAD_binding_10; pfam13460 369723002713 NAD binding site [chemical binding]; other site 369723002714 substrate binding site [chemical binding]; other site 369723002715 putative active site [active] 369723002716 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723002717 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723002718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723002719 Domain of unknown function (DUF385); Region: DUF385; pfam04075 369723002720 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 369723002721 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 369723002722 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 369723002723 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723002724 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 369723002725 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 369723002726 D-pathway; other site 369723002727 Putative ubiquinol binding site [chemical binding]; other site 369723002728 Low-spin heme (heme b) binding site [chemical binding]; other site 369723002729 Putative water exit pathway; other site 369723002730 Binuclear center (heme o3/CuB) [ion binding]; other site 369723002731 K-pathway; other site 369723002732 Putative proton exit pathway; other site 369723002733 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 369723002734 Isochorismatase family; Region: Isochorismatase; pfam00857 369723002735 catalytic triad [active] 369723002736 metal binding site [ion binding]; metal-binding site 369723002737 conserved cis-peptide bond; other site 369723002738 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 369723002739 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 369723002740 active site 369723002741 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 369723002742 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 369723002743 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 369723002744 MPN+ (JAMM) motif; other site 369723002745 Zinc-binding site [ion binding]; other site 369723002746 Ubiquitin-like proteins; Region: UBQ; cl00155 369723002747 charged pocket; other site 369723002748 hydrophobic patch; other site 369723002749 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 369723002750 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 369723002751 dimer interface [polypeptide binding]; other site 369723002752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723002753 catalytic residue [active] 369723002754 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 369723002755 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723002756 ribonuclease PH; Reviewed; Region: rph; PRK00173 369723002757 Ribonuclease PH; Region: RNase_PH_bact; cd11362 369723002758 hexamer interface [polypeptide binding]; other site 369723002759 active site 369723002760 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 369723002761 active site 369723002762 dimerization interface [polypeptide binding]; other site 369723002763 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 369723002764 active sites [active] 369723002765 tetramer interface [polypeptide binding]; other site 369723002766 imidazolonepropionase; Provisional; Region: PRK14085 369723002767 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 369723002768 active site 369723002769 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 369723002770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723002771 active site 369723002772 allantoate amidohydrolase; Reviewed; Region: PRK09290 369723002773 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 369723002774 active site 369723002775 metal binding site [ion binding]; metal-binding site 369723002776 dimer interface [polypeptide binding]; other site 369723002777 urocanate hydratase; Provisional; Region: PRK05414 369723002778 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 369723002779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 369723002780 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 369723002781 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 369723002782 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 369723002783 MOSC domain; Region: MOSC; pfam03473 369723002784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723002785 Coenzyme A binding pocket [chemical binding]; other site 369723002786 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 369723002787 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 369723002788 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 369723002789 catalytic triad [active] 369723002790 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 369723002791 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 369723002792 PDGLE domain; Region: PDGLE; pfam13190 369723002793 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 369723002794 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723002795 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723002796 Walker A/P-loop; other site 369723002797 ATP binding site [chemical binding]; other site 369723002798 Q-loop/lid; other site 369723002799 ABC transporter signature motif; other site 369723002800 Walker B; other site 369723002801 D-loop; other site 369723002802 H-loop/switch region; other site 369723002803 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 369723002804 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 369723002805 catalytic residues [active] 369723002806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723002807 CopC domain; Region: CopC; pfam04234 369723002808 Copper resistance protein D; Region: CopD; cl00563 369723002809 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 369723002810 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 369723002811 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 369723002812 catalytic site [active] 369723002813 putative active site [active] 369723002814 putative substrate binding site [chemical binding]; other site 369723002815 dimer interface [polypeptide binding]; other site 369723002816 Bacterial Ig-like domain; Region: Big_5; pfam13205 369723002817 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 369723002818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 369723002819 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 369723002820 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723002821 nudix motif; other site 369723002822 Flavoprotein; Region: Flavoprotein; pfam02441 369723002823 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723002824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723002825 sequence-specific DNA binding site [nucleotide binding]; other site 369723002826 salt bridge; other site 369723002827 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 369723002828 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 369723002829 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723002830 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 369723002831 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 369723002832 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 369723002833 active site 369723002834 metal-binding site [ion binding] 369723002835 nucleotide-binding site [chemical binding]; other site 369723002836 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 369723002837 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 369723002838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723002839 NADH(P)-binding; Region: NAD_binding_10; pfam13460 369723002840 NAD(P) binding site [chemical binding]; other site 369723002841 active site 369723002842 Replication-relaxation; Region: Replic_Relax; pfam13814 369723002843 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 369723002844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723002845 motif II; other site 369723002846 Replication-relaxation; Region: Replic_Relax; pfam13814 369723002847 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723002848 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723002849 hypothetical protein; Provisional; Region: PRK06762 369723002850 hypothetical protein; Provisional; Region: PRK06762 369723002851 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 369723002852 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 369723002853 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 369723002854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723002855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723002856 putative substrate translocation pore; other site 369723002857 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723002858 hypothetical protein; Provisional; Region: PRK06762 369723002859 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 369723002860 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 369723002861 MarR family; Region: MarR_2; pfam12802 369723002862 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 369723002863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723002864 substrate binding site [chemical binding]; other site 369723002865 oxyanion hole (OAH) forming residues; other site 369723002866 trimer interface [polypeptide binding]; other site 369723002867 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 369723002868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723002869 DNA binding residues [nucleotide binding] 369723002870 putative dimer interface [polypeptide binding]; other site 369723002871 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 369723002872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723002873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002875 FAD dependent oxidoreductase; Region: DAO; pfam01266 369723002876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723002877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 369723002878 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723002879 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 369723002880 putative NAD(P) binding site [chemical binding]; other site 369723002881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723002882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002883 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 369723002884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723002885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723002886 sequence-specific DNA binding site [nucleotide binding]; other site 369723002887 salt bridge; other site 369723002888 Cupin domain; Region: Cupin_2; pfam07883 369723002889 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723002890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723002891 S-adenosylmethionine binding site [chemical binding]; other site 369723002892 FAD binding domain; Region: FAD_binding_3; pfam01494 369723002893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723002894 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723002895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723002896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723002897 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 369723002898 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 369723002899 acyl-activating enzyme (AAE) consensus motif; other site 369723002900 putative AMP binding site [chemical binding]; other site 369723002901 putative active site [active] 369723002902 putative CoA binding site [chemical binding]; other site 369723002903 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002904 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723002905 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002906 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002907 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002908 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002909 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723002911 NAD(P) binding site [chemical binding]; other site 369723002912 active site 369723002913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 369723002914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723002915 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002916 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002917 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002918 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002919 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002920 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002921 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723002922 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723002923 FAD binding domain; Region: FAD_binding_4; pfam01565 369723002924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 369723002925 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 369723002926 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 369723002927 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 369723002928 short chain dehydrogenase; Provisional; Region: PRK07109 369723002929 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 369723002930 putative NAD(P) binding site [chemical binding]; other site 369723002931 active site 369723002932 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 369723002933 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723002934 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723002935 DNA binding site [nucleotide binding] 369723002936 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 369723002937 ligand binding site [chemical binding]; other site 369723002938 dimerization interface [polypeptide binding]; other site 369723002939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723002940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 369723002941 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 369723002942 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723002944 dimer interface [polypeptide binding]; other site 369723002945 conserved gate region; other site 369723002946 putative PBP binding loops; other site 369723002947 ABC-ATPase subunit interface; other site 369723002948 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 369723002949 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 369723002950 putative active site [active] 369723002951 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 369723002952 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 369723002953 active site 369723002954 alpha-mannosidase; Provisional; Region: PRK09819 369723002955 catalytic site [active] 369723002956 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 369723002957 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 369723002958 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002959 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002960 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723002961 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002962 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723002963 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723002964 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723002965 Protein of unknown function DUF72; Region: DUF72; pfam01904 369723002966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723002967 dimer interface [polypeptide binding]; other site 369723002968 phosphorylation site [posttranslational modification] 369723002969 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 369723002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723002971 ATP binding site [chemical binding]; other site 369723002972 Mg2+ binding site [ion binding]; other site 369723002973 G-X-G motif; other site 369723002974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723002975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723002976 active site 369723002977 phosphorylation site [posttranslational modification] 369723002978 intermolecular recognition site; other site 369723002979 dimerization interface [polypeptide binding]; other site 369723002980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723002981 DNA binding site [nucleotide binding] 369723002982 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 369723002983 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 369723002984 Transcriptional regulators [Transcription]; Region: MarR; COG1846 369723002985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 369723002986 non-specific DNA interactions [nucleotide binding]; other site 369723002987 DNA binding site [nucleotide binding] 369723002988 sequence specific DNA binding site [nucleotide binding]; other site 369723002989 putative cAMP binding site [chemical binding]; other site 369723002990 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 369723002991 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723002992 nucleotide binding site [chemical binding]; other site 369723002993 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 369723002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723002995 Walker A/P-loop; other site 369723002996 ATP binding site [chemical binding]; other site 369723002997 Q-loop/lid; other site 369723002998 ABC transporter signature motif; other site 369723002999 Walker B; other site 369723003000 D-loop; other site 369723003001 H-loop/switch region; other site 369723003002 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723003003 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 369723003004 substrate binding site [chemical binding]; other site 369723003005 dimer interface [polypeptide binding]; other site 369723003006 ATP binding site [chemical binding]; other site 369723003007 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723003008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723003009 enoyl-CoA hydratase; Provisional; Region: PRK05862 369723003010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723003011 substrate binding site [chemical binding]; other site 369723003012 oxyanion hole (OAH) forming residues; other site 369723003013 trimer interface [polypeptide binding]; other site 369723003014 hypothetical protein; Provisional; Region: PRK05858 369723003015 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 369723003016 PYR/PP interface [polypeptide binding]; other site 369723003017 dimer interface [polypeptide binding]; other site 369723003018 TPP binding site [chemical binding]; other site 369723003019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 369723003020 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 369723003021 TPP-binding site; other site 369723003022 dimer interface [polypeptide binding]; other site 369723003023 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 369723003024 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 369723003025 Ligand binding site [chemical binding]; other site 369723003026 Electron transfer flavoprotein domain; Region: ETF; pfam01012 369723003027 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 369723003028 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 369723003029 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 369723003030 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 369723003031 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 369723003032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 369723003033 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 369723003034 Soluble P-type ATPase [General function prediction only]; Region: COG4087 369723003035 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 369723003036 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 369723003037 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 369723003038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723003039 catalytic residue [active] 369723003040 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 369723003041 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 369723003042 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 369723003043 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 369723003044 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 369723003045 nucleotide binding pocket [chemical binding]; other site 369723003046 K-X-D-G motif; other site 369723003047 catalytic site [active] 369723003048 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 369723003049 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 369723003050 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 369723003051 Dimer interface [polypeptide binding]; other site 369723003052 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723003053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723003054 metal binding site [ion binding]; metal-binding site 369723003055 active site 369723003056 I-site; other site 369723003057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723003058 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 369723003059 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 369723003060 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 369723003061 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 369723003062 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 369723003063 GatB domain; Region: GatB_Yqey; smart00845 369723003064 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 369723003065 TPP-binding site [chemical binding]; other site 369723003066 PYR/PP interface [polypeptide binding]; other site 369723003067 dimer interface [polypeptide binding]; other site 369723003068 TPP binding site [chemical binding]; other site 369723003069 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 369723003070 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 369723003071 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723003072 active site 369723003073 metal binding site [ion binding]; metal-binding site 369723003074 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 369723003075 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 369723003076 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 369723003077 putative ligand binding site [chemical binding]; other site 369723003078 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 369723003079 putative NAD binding site [chemical binding]; other site 369723003080 catalytic site [active] 369723003081 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 369723003082 Dehydratase family; Region: ILVD_EDD; cl00340 369723003083 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 369723003084 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 369723003085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723003086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723003087 metal binding site [ion binding]; metal-binding site 369723003088 active site 369723003089 I-site; other site 369723003090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723003091 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 369723003092 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 369723003093 PYR/PP interface [polypeptide binding]; other site 369723003094 dimer interface [polypeptide binding]; other site 369723003095 TPP binding site [chemical binding]; other site 369723003096 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 369723003097 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 369723003098 TPP-binding site [chemical binding]; other site 369723003099 dimer interface [polypeptide binding]; other site 369723003100 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 369723003101 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 369723003102 putative valine binding site [chemical binding]; other site 369723003103 dimer interface [polypeptide binding]; other site 369723003104 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 369723003105 ketol-acid reductoisomerase; Provisional; Region: PRK05479 369723003106 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 369723003107 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 369723003108 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 369723003109 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 369723003110 ligand binding site [chemical binding]; other site 369723003111 NAD binding site [chemical binding]; other site 369723003112 dimerization interface [polypeptide binding]; other site 369723003113 catalytic site [active] 369723003114 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 369723003115 putative L-serine binding site [chemical binding]; other site 369723003116 ApbE family; Region: ApbE; pfam02424 369723003117 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 369723003118 tartrate dehydrogenase; Region: TTC; TIGR02089 369723003119 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 369723003120 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 369723003121 homodimer interface [polypeptide binding]; other site 369723003122 substrate-cofactor binding pocket; other site 369723003123 catalytic residue [active] 369723003124 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 369723003125 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 369723003126 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 369723003127 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 369723003128 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 369723003129 active site 369723003130 catalytic residues [active] 369723003131 metal binding site [ion binding]; metal-binding site 369723003132 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 369723003133 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 369723003134 putative catalytic site [active] 369723003135 putative metal binding site [ion binding]; other site 369723003136 putative phosphate binding site [ion binding]; other site 369723003137 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723003138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723003139 Walker A motif; other site 369723003140 ATP binding site [chemical binding]; other site 369723003141 Walker B motif; other site 369723003142 arginine finger; other site 369723003143 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 369723003144 Protein of unknown function DUF58; Region: DUF58; pfam01882 369723003145 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 369723003146 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 369723003147 metal ion-dependent adhesion site (MIDAS); other site 369723003148 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 369723003149 hypothetical protein; Provisional; Region: PRK09256 369723003150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723003151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723003152 hypothetical protein; Provisional; Region: PRK07588 369723003153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723003154 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 369723003155 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 369723003156 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 369723003157 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 369723003158 Transcriptional regulator [Transcription]; Region: IclR; COG1414 369723003159 Bacterial transcriptional regulator; Region: IclR; pfam01614 369723003160 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 369723003161 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 369723003162 substrate binding site [chemical binding]; other site 369723003163 ligand binding site [chemical binding]; other site 369723003164 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 369723003165 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 369723003166 substrate binding site [chemical binding]; other site 369723003167 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 369723003168 IHF dimer interface [polypeptide binding]; other site 369723003169 IHF - DNA interface [nucleotide binding]; other site 369723003170 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 369723003171 active site 369723003172 Ap6A binding site [chemical binding]; other site 369723003173 nudix motif; other site 369723003174 metal binding site [ion binding]; metal-binding site 369723003175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723003176 catalytic core [active] 369723003177 polyphosphate kinase; Provisional; Region: PRK05443 369723003178 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 369723003179 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 369723003180 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 369723003181 putative domain interface [polypeptide binding]; other site 369723003182 putative active site [active] 369723003183 catalytic site [active] 369723003184 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 369723003185 putative domain interface [polypeptide binding]; other site 369723003186 putative active site [active] 369723003187 catalytic site [active] 369723003188 Guanylyl transferase CofC like; Region: CofC; cl17472 369723003189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723003190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 369723003191 putative acyl-acceptor binding pocket; other site 369723003192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 369723003193 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 369723003194 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 369723003195 cystathionine gamma-lyase; Validated; Region: PRK07582 369723003196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723003197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723003198 catalytic residue [active] 369723003199 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 369723003200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723003201 nucleotide binding site [chemical binding]; other site 369723003202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723003203 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723003204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723003205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003206 non-specific DNA binding site [nucleotide binding]; other site 369723003207 salt bridge; other site 369723003208 sequence-specific DNA binding site [nucleotide binding]; other site 369723003209 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 369723003210 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 369723003211 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 369723003212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723003213 AsnC family; Region: AsnC_trans_reg; pfam01037 369723003214 thiamine monophosphate kinase; Provisional; Region: PRK05731 369723003215 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 369723003216 ATP binding site [chemical binding]; other site 369723003217 dimerization interface [polypeptide binding]; other site 369723003218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723003219 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 369723003220 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 369723003221 DAK2 domain; Region: Dak2; pfam02734 369723003222 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 369723003223 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 369723003224 generic binding surface II; other site 369723003225 ssDNA binding site; other site 369723003226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723003227 ATP binding site [chemical binding]; other site 369723003228 putative Mg++ binding site [ion binding]; other site 369723003229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723003230 nucleotide binding region [chemical binding]; other site 369723003231 ATP-binding site [chemical binding]; other site 369723003232 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 369723003233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723003234 S-adenosylmethionine binding site [chemical binding]; other site 369723003235 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 369723003236 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 369723003237 active site 369723003238 (T/H)XGH motif; other site 369723003239 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 369723003240 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 369723003241 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 369723003242 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 369723003243 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 369723003244 dimerization interface [polypeptide binding]; other site 369723003245 active site 369723003246 metal binding site [ion binding]; metal-binding site 369723003247 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 369723003248 dsRNA binding site [nucleotide binding]; other site 369723003249 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 369723003250 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 369723003251 DNA binding site [nucleotide binding] 369723003252 catalytic residue [active] 369723003253 H2TH interface [polypeptide binding]; other site 369723003254 putative catalytic residues [active] 369723003255 turnover-facilitating residue; other site 369723003256 intercalation triad [nucleotide binding]; other site 369723003257 8OG recognition residue [nucleotide binding]; other site 369723003258 putative reading head residues; other site 369723003259 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 369723003260 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 369723003261 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 369723003262 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 369723003263 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 369723003264 AAA domain; Region: AAA_23; pfam13476 369723003265 Walker A/P-loop; other site 369723003266 ATP binding site [chemical binding]; other site 369723003267 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 369723003268 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 369723003269 ABC transporter signature motif; other site 369723003270 Walker B; other site 369723003271 D-loop; other site 369723003272 H-loop/switch region; other site 369723003273 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 369723003274 Protein of unknown function (DUF664); Region: DUF664; pfam04978 369723003275 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723003276 putative active site [active] 369723003277 putative metal binding site [ion binding]; other site 369723003278 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 369723003279 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 369723003280 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 369723003281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723003282 Phosphotransferase enzyme family; Region: APH; pfam01636 369723003283 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 369723003284 active site 369723003285 substrate binding site [chemical binding]; other site 369723003286 ATP binding site [chemical binding]; other site 369723003287 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 369723003288 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 369723003289 Nitrogen regulatory protein P-II; Region: P-II; smart00938 369723003290 PII uridylyl-transferase; Provisional; Region: PRK03381 369723003291 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 369723003292 metal binding triad; other site 369723003293 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 369723003294 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 369723003295 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 369723003296 signal recognition particle protein; Provisional; Region: PRK10867 369723003297 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 369723003298 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 369723003299 P loop; other site 369723003300 GTP binding site [chemical binding]; other site 369723003301 Signal peptide binding domain; Region: SRP_SPB; pfam02978 369723003302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723003303 active site 369723003304 prolyl-tRNA synthetase; Provisional; Region: PRK08661 369723003305 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 369723003306 dimer interface [polypeptide binding]; other site 369723003307 motif 1; other site 369723003308 active site 369723003309 motif 2; other site 369723003310 motif 3; other site 369723003311 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 369723003312 anticodon binding site; other site 369723003313 Protein of unknown function (DUF402); Region: DUF402; pfam04167 369723003314 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 369723003315 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 369723003316 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 369723003317 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 369723003318 RimM N-terminal domain; Region: RimM; pfam01782 369723003319 PRC-barrel domain; Region: PRC; pfam05239 369723003320 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 369723003321 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 369723003322 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 369723003323 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 369723003324 Catalytic site [active] 369723003325 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 369723003326 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 369723003327 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 369723003328 Catalytic site [active] 369723003329 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 369723003330 RNA/DNA hybrid binding site [nucleotide binding]; other site 369723003331 active site 369723003332 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 369723003333 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 369723003334 Peptidase family M23; Region: Peptidase_M23; pfam01551 369723003335 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 369723003336 active site 369723003337 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 369723003338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723003339 active site 369723003340 DNA binding site [nucleotide binding] 369723003341 Int/Topo IB signature motif; other site 369723003342 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 369723003343 DNA protecting protein DprA; Region: dprA; TIGR00732 369723003344 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 369723003345 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 369723003346 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 369723003347 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 369723003348 hypothetical protein; Reviewed; Region: PRK12497 369723003349 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 369723003350 rRNA interaction site [nucleotide binding]; other site 369723003351 S8 interaction site; other site 369723003352 putative laminin-1 binding site; other site 369723003353 elongation factor Ts; Provisional; Region: tsf; PRK09377 369723003354 UBA/TS-N domain; Region: UBA; pfam00627 369723003355 Elongation factor TS; Region: EF_TS; pfam00889 369723003356 Elongation factor TS; Region: EF_TS; pfam00889 369723003357 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 369723003358 putative nucleotide binding site [chemical binding]; other site 369723003359 uridine monophosphate binding site [chemical binding]; other site 369723003360 homohexameric interface [polypeptide binding]; other site 369723003361 ribosome recycling factor; Reviewed; Region: frr; PRK00083 369723003362 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 369723003363 hinge region; other site 369723003364 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 369723003365 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 369723003366 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 369723003367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723003368 FeS/SAM binding site; other site 369723003369 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723003370 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723003371 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 369723003372 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723003373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 369723003374 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 369723003375 iron-sulfur cluster [ion binding]; other site 369723003376 [2Fe-2S] cluster binding site [ion binding]; other site 369723003377 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 369723003378 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 369723003379 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723003380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003381 non-specific DNA binding site [nucleotide binding]; other site 369723003382 salt bridge; other site 369723003383 sequence-specific DNA binding site [nucleotide binding]; other site 369723003384 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 369723003385 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 369723003386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723003387 Cytochrome P450; Region: p450; cl12078 369723003388 FtsX-like permease family; Region: FtsX; pfam02687 369723003389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 369723003390 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 369723003391 Walker A/P-loop; other site 369723003392 ATP binding site [chemical binding]; other site 369723003393 Q-loop/lid; other site 369723003394 ABC transporter signature motif; other site 369723003395 Walker B; other site 369723003396 D-loop; other site 369723003397 H-loop/switch region; other site 369723003398 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723003399 Transcriptional regulator PadR-like family; Region: PadR; cl17335 369723003400 Clp amino terminal domain; Region: Clp_N; pfam02861 369723003401 Clp amino terminal domain; Region: Clp_N; pfam02861 369723003402 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 369723003403 Predicted amidohydrolase [General function prediction only]; Region: COG0388 369723003404 active site 369723003405 catalytic triad [active] 369723003406 dimer interface [polypeptide binding]; other site 369723003407 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723003408 active site 369723003409 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723003410 HTH domain; Region: HTH_11; pfam08279 369723003411 WYL domain; Region: WYL; pfam13280 369723003412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003413 non-specific DNA binding site [nucleotide binding]; other site 369723003414 salt bridge; other site 369723003415 sequence-specific DNA binding site [nucleotide binding]; other site 369723003416 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 369723003417 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 369723003418 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 369723003419 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 369723003420 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 369723003421 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 369723003422 active site 369723003423 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 369723003424 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 369723003425 putative substrate binding region [chemical binding]; other site 369723003426 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 369723003427 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 369723003428 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 369723003429 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 369723003430 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723003431 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 369723003432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723003433 DNA binding residues [nucleotide binding] 369723003434 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 369723003435 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723003436 Protein of unknown function (DUF664); Region: DUF664; pfam04978 369723003437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723003438 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723003439 Walker A/P-loop; other site 369723003440 ATP binding site [chemical binding]; other site 369723003441 Q-loop/lid; other site 369723003442 ABC transporter signature motif; other site 369723003443 Walker B; other site 369723003444 D-loop; other site 369723003445 H-loop/switch region; other site 369723003446 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723003447 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 369723003448 Walker A/P-loop; other site 369723003449 ATP binding site [chemical binding]; other site 369723003450 Q-loop/lid; other site 369723003451 ABC transporter signature motif; other site 369723003452 Walker B; other site 369723003453 D-loop; other site 369723003454 H-loop/switch region; other site 369723003455 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 369723003456 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 369723003457 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 369723003458 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723003459 dimer interface [polypeptide binding]; other site 369723003460 active site 369723003461 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 369723003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723003463 S-adenosylmethionine binding site [chemical binding]; other site 369723003464 PAS domain S-box; Region: sensory_box; TIGR00229 369723003465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 369723003466 putative active site [active] 369723003467 heme pocket [chemical binding]; other site 369723003468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723003469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723003470 metal binding site [ion binding]; metal-binding site 369723003471 active site 369723003472 I-site; other site 369723003473 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723003474 methionine aminopeptidase; Provisional; Region: PRK12318 369723003475 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 369723003476 active site 369723003477 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 369723003478 Domain of unknown function (DUF385); Region: DUF385; cl04387 369723003479 ribosome maturation protein RimP; Reviewed; Region: PRK00092 369723003480 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 369723003481 putative RNA binding site [nucleotide binding]; other site 369723003482 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 369723003483 NusA N-terminal domain; Region: NusA_N; pfam08529 369723003484 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 369723003485 RNA binding site [nucleotide binding]; other site 369723003486 homodimer interface [polypeptide binding]; other site 369723003487 NusA-like KH domain; Region: KH_5; pfam13184 369723003488 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 369723003489 G-X-X-G motif; other site 369723003490 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 369723003491 putative RNA binding cleft [nucleotide binding]; other site 369723003492 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 369723003493 translation initiation factor IF-2; Region: IF-2; TIGR00487 369723003494 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 369723003495 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 369723003496 G1 box; other site 369723003497 putative GEF interaction site [polypeptide binding]; other site 369723003498 GTP/Mg2+ binding site [chemical binding]; other site 369723003499 Switch I region; other site 369723003500 G2 box; other site 369723003501 G3 box; other site 369723003502 Switch II region; other site 369723003503 G4 box; other site 369723003504 G5 box; other site 369723003505 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 369723003506 Translation-initiation factor 2; Region: IF-2; pfam11987 369723003507 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 369723003508 Protein of unknown function (DUF503); Region: DUF503; pfam04456 369723003509 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 369723003510 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 369723003511 DHH family; Region: DHH; pfam01368 369723003512 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 369723003513 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 369723003514 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 369723003515 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 369723003516 RNA binding site [nucleotide binding]; other site 369723003517 active site 369723003518 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 369723003519 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 369723003520 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 369723003521 active site 369723003522 Riboflavin kinase; Region: Flavokinase; pfam01687 369723003523 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 369723003524 16S/18S rRNA binding site [nucleotide binding]; other site 369723003525 S13e-L30e interaction site [polypeptide binding]; other site 369723003526 25S rRNA binding site [nucleotide binding]; other site 369723003527 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 369723003528 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 369723003529 RNase E interface [polypeptide binding]; other site 369723003530 trimer interface [polypeptide binding]; other site 369723003531 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 369723003532 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 369723003533 RNase E interface [polypeptide binding]; other site 369723003534 trimer interface [polypeptide binding]; other site 369723003535 active site 369723003536 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 369723003537 putative nucleic acid binding region [nucleotide binding]; other site 369723003538 G-X-X-G motif; other site 369723003539 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 369723003540 RNA binding site [nucleotide binding]; other site 369723003541 domain interface; other site 369723003542 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 369723003543 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 369723003544 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723003545 dihydrodipicolinate reductase; Provisional; Region: PRK00048 369723003546 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 369723003547 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 369723003548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723003549 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 369723003550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 369723003551 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 369723003552 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 369723003553 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 369723003554 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 369723003555 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 369723003556 dimer interface [polypeptide binding]; other site 369723003557 active site 369723003558 catalytic residue [active] 369723003559 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 369723003560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 369723003561 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 369723003562 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 369723003563 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 369723003564 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 369723003565 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 369723003566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723003567 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 369723003568 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 369723003569 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 369723003570 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 369723003571 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 369723003572 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 369723003573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723003574 FeS/SAM binding site; other site 369723003575 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 369723003576 Competence-damaged protein; Region: CinA; pfam02464 369723003577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723003578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003579 non-specific DNA binding site [nucleotide binding]; other site 369723003580 salt bridge; other site 369723003581 sequence-specific DNA binding site [nucleotide binding]; other site 369723003582 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 369723003583 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 369723003584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723003585 Interdomain contacts; other site 369723003586 Cytokine receptor motif; other site 369723003587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003588 non-specific DNA binding site [nucleotide binding]; other site 369723003589 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723003590 salt bridge; other site 369723003591 sequence-specific DNA binding site [nucleotide binding]; other site 369723003592 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 369723003593 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723003594 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 369723003595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723003596 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 369723003597 ATP binding site [chemical binding]; other site 369723003598 putative Mg++ binding site [ion binding]; other site 369723003599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723003600 nucleotide binding region [chemical binding]; other site 369723003601 ATP-binding site [chemical binding]; other site 369723003602 DEAD/H associated; Region: DEAD_assoc; pfam08494 369723003603 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 369723003604 Peptidase family M28; Region: Peptidase_M28; pfam04389 369723003605 active site 369723003606 metal binding site [ion binding]; metal-binding site 369723003607 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 369723003608 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 369723003609 Domain of unknown function DUF21; Region: DUF21; pfam01595 369723003610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 369723003611 Transporter associated domain; Region: CorC_HlyC; pfam03471 369723003612 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 369723003613 Domain of unknown function DUF21; Region: DUF21; pfam01595 369723003614 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 369723003615 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 369723003616 leucine export protein LeuE; Provisional; Region: PRK10958 369723003617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723003618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723003619 putative substrate translocation pore; other site 369723003620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723003621 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723003622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723003623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723003624 dimerization interface [polypeptide binding]; other site 369723003625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723003626 dimer interface [polypeptide binding]; other site 369723003627 phosphorylation site [posttranslational modification] 369723003628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723003629 ATP binding site [chemical binding]; other site 369723003630 Mg2+ binding site [ion binding]; other site 369723003631 G-X-G motif; other site 369723003632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723003633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723003634 active site 369723003635 phosphorylation site [posttranslational modification] 369723003636 intermolecular recognition site; other site 369723003637 dimerization interface [polypeptide binding]; other site 369723003638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723003639 DNA binding site [nucleotide binding] 369723003640 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 369723003641 MMPL family; Region: MMPL; pfam03176 369723003642 MMPL family; Region: MMPL; pfam03176 369723003643 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 369723003644 recombinase A; Provisional; Region: recA; PRK09354 369723003645 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 369723003646 hexamer interface [polypeptide binding]; other site 369723003647 Walker A motif; other site 369723003648 ATP binding site [chemical binding]; other site 369723003649 Walker B motif; other site 369723003650 recombination regulator RecX; Reviewed; Region: recX; PRK00117 369723003651 ribonuclease Y; Region: RNase_Y; TIGR03319 369723003652 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 369723003653 Zn2+ binding site [ion binding]; other site 369723003654 Mg2+ binding site [ion binding]; other site 369723003655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723003656 dimer interface [polypeptide binding]; other site 369723003657 conserved gate region; other site 369723003658 putative PBP binding loops; other site 369723003659 ABC-ATPase subunit interface; other site 369723003660 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 369723003661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723003662 dimer interface [polypeptide binding]; other site 369723003663 conserved gate region; other site 369723003664 putative PBP binding loops; other site 369723003665 ABC-ATPase subunit interface; other site 369723003666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 369723003667 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 369723003668 substrate binding pocket [chemical binding]; other site 369723003669 membrane-bound complex binding site; other site 369723003670 hinge residues; other site 369723003671 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 369723003672 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 369723003673 Walker A/P-loop; other site 369723003674 ATP binding site [chemical binding]; other site 369723003675 Q-loop/lid; other site 369723003676 ABC transporter signature motif; other site 369723003677 Walker B; other site 369723003678 D-loop; other site 369723003679 H-loop/switch region; other site 369723003680 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723003681 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 369723003682 active site 369723003683 catalytic residues [active] 369723003684 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 369723003685 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723003686 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 369723003687 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723003688 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723003689 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 369723003690 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 369723003691 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 369723003692 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 369723003693 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 369723003694 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 369723003695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723003696 FeS/SAM binding site; other site 369723003697 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 369723003698 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 369723003699 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 369723003700 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 369723003701 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 369723003702 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 369723003703 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 369723003704 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 369723003705 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 369723003706 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 369723003707 amphipathic channel; other site 369723003708 Asn-Pro-Ala signature motifs; other site 369723003709 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 369723003710 Low molecular weight phosphatase family; Region: LMWPc; cl00105 369723003711 active site 369723003712 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 369723003713 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 369723003714 Malic enzyme, N-terminal domain; Region: malic; pfam00390 369723003715 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 369723003716 NAD(P) binding pocket [chemical binding]; other site 369723003717 GTPases [General function prediction only]; Region: HflX; COG2262 369723003718 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 369723003719 HflX GTPase family; Region: HflX; cd01878 369723003720 G1 box; other site 369723003721 GTP/Mg2+ binding site [chemical binding]; other site 369723003722 Switch I region; other site 369723003723 G2 box; other site 369723003724 G3 box; other site 369723003725 Switch II region; other site 369723003726 G4 box; other site 369723003727 G5 box; other site 369723003728 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 369723003729 LexA repressor; Validated; Region: PRK00215 369723003730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723003731 putative DNA binding site [nucleotide binding]; other site 369723003732 putative Zn2+ binding site [ion binding]; other site 369723003733 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 369723003734 Catalytic site [active] 369723003735 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 369723003736 ATP cone domain; Region: ATP-cone; pfam03477 369723003737 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 369723003738 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 369723003739 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 369723003740 active site 369723003741 dimer interface [polypeptide binding]; other site 369723003742 effector binding site; other site 369723003743 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 369723003744 TSCPD domain; Region: TSCPD; pfam12637 369723003745 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 369723003746 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 369723003747 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 369723003748 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 369723003749 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 369723003750 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 369723003751 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 369723003752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723003753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723003754 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 369723003755 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 369723003756 active site residue [active] 369723003757 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 369723003758 active site residue [active] 369723003759 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 369723003760 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 369723003761 active site 369723003762 Zn binding site [ion binding]; other site 369723003763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723003764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723003765 Coenzyme A binding pocket [chemical binding]; other site 369723003766 CoA binding domain; Region: CoA_binding_2; pfam13380 369723003767 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 369723003768 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 369723003769 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 369723003770 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 369723003771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723003772 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 369723003773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723003774 DNA binding residues [nucleotide binding] 369723003775 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 369723003776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723003777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723003778 DNA binding residues [nucleotide binding] 369723003779 dimerization interface [polypeptide binding]; other site 369723003780 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 369723003781 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 369723003782 active site 369723003783 catalytic triad [active] 369723003784 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 369723003785 PA/protease or protease-like domain interface [polypeptide binding]; other site 369723003786 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 369723003787 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723003788 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 369723003789 active site 369723003790 catalytic triad [active] 369723003791 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 369723003792 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 369723003793 PA/protease or protease-like domain interface [polypeptide binding]; other site 369723003794 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 369723003795 putative active site [active] 369723003796 dimerization interface [polypeptide binding]; other site 369723003797 putative tRNAtyr binding site [nucleotide binding]; other site 369723003798 putative methyltransferase; Provisional; Region: PRK14967 369723003799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723003800 S-adenosylmethionine binding site [chemical binding]; other site 369723003801 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 369723003802 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 369723003803 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723003804 substrate binding site [chemical binding]; other site 369723003805 ATP binding site [chemical binding]; other site 369723003806 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 369723003807 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 369723003808 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 369723003809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723003810 ATP binding site [chemical binding]; other site 369723003811 putative Mg++ binding site [ion binding]; other site 369723003812 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 369723003813 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 369723003814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723003815 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 369723003816 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723003817 DNA binding residues [nucleotide binding] 369723003818 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 369723003819 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 369723003820 active site 369723003821 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 369723003822 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 369723003823 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 369723003824 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 369723003825 trimer interface [polypeptide binding]; other site 369723003826 active site 369723003827 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 369723003828 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 369723003829 ssDNA binding site; other site 369723003830 generic binding surface II; other site 369723003831 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 369723003832 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 369723003833 TrkA-N domain; Region: TrkA_N; pfam02254 369723003834 TrkA-C domain; Region: TrkA_C; pfam02080 369723003835 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 369723003836 TrkA-N domain; Region: TrkA_N; pfam02254 369723003837 TrkA-C domain; Region: TrkA_C; pfam02080 369723003838 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 369723003839 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 369723003840 TRAM domain; Region: TRAM; pfam01938 369723003841 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 369723003842 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 369723003843 TPP-binding site; other site 369723003844 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 369723003845 PYR/PP interface [polypeptide binding]; other site 369723003846 dimer interface [polypeptide binding]; other site 369723003847 TPP binding site [chemical binding]; other site 369723003848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723003850 putative substrate translocation pore; other site 369723003851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723003852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723003853 Predicted flavoprotein [General function prediction only]; Region: COG0431 369723003854 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723003855 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 369723003856 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 369723003857 DNA binding residues [nucleotide binding] 369723003858 dimer interface [polypeptide binding]; other site 369723003859 [2Fe-2S] cluster binding site [ion binding]; other site 369723003860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723003861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723003862 active site 369723003863 phosphorylation site [posttranslational modification] 369723003864 intermolecular recognition site; other site 369723003865 dimerization interface [polypeptide binding]; other site 369723003866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723003867 DNA binding site [nucleotide binding] 369723003868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723003869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 369723003870 dimerization interface [polypeptide binding]; other site 369723003871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723003872 dimer interface [polypeptide binding]; other site 369723003873 phosphorylation site [posttranslational modification] 369723003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723003875 ATP binding site [chemical binding]; other site 369723003876 Mg2+ binding site [ion binding]; other site 369723003877 G-X-G motif; other site 369723003878 hypothetical protein; Provisional; Region: PRK06834 369723003879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723003880 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723003881 Uncharacterized conserved protein [Function unknown]; Region: COG1683 369723003882 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 369723003883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723003884 motif II; other site 369723003885 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 369723003886 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723003887 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 369723003888 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723003889 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 369723003890 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 369723003891 DDE superfamily endonuclease; Region: DDE_5; cl17874 369723003892 DDE superfamily endonuclease; Region: DDE_5; cl17874 369723003893 MarR family; Region: MarR_2; cl17246 369723003894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723003895 active site 369723003896 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 369723003897 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723003898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723003899 non-specific DNA binding site [nucleotide binding]; other site 369723003900 sequence-specific DNA binding site [nucleotide binding]; other site 369723003901 salt bridge; other site 369723003902 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723003903 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 369723003904 Amidohydrolase; Region: Amidohydro_4; pfam13147 369723003905 active site 369723003906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723003907 Coenzyme A binding pocket [chemical binding]; other site 369723003908 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723003909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723003910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723003911 ABC transporter signature motif; other site 369723003912 Walker B; other site 369723003913 D-loop; other site 369723003914 H-loop/switch region; other site 369723003915 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723003916 substrate binding site [chemical binding]; other site 369723003917 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 369723003918 oxyanion hole (OAH) forming residues; other site 369723003919 trimer interface [polypeptide binding]; other site 369723003920 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723003921 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 369723003922 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723003923 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 369723003924 dimer interface [polypeptide binding]; other site 369723003925 active site 369723003926 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 369723003927 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 369723003928 catalytic site [active] 369723003929 putative active site [active] 369723003930 putative substrate binding site [chemical binding]; other site 369723003931 HRDC domain; Region: HRDC; cl02578 369723003932 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 369723003933 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 369723003934 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 369723003935 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 369723003936 substrate binding site [chemical binding]; other site 369723003937 active site 369723003938 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 369723003939 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 369723003940 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 369723003941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723003942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723003943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 369723003944 dimerization interface [polypeptide binding]; other site 369723003945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723003946 Coenzyme A binding pocket [chemical binding]; other site 369723003947 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 369723003948 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723003949 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723003950 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 369723003951 CGNR zinc finger; Region: zf-CGNR; pfam11706 369723003952 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 369723003953 SelR domain; Region: SelR; pfam01641 369723003954 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 369723003955 nucleotide binding site [chemical binding]; other site 369723003956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 369723003957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723003958 Coenzyme A binding pocket [chemical binding]; other site 369723003959 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 369723003960 TAP-like protein; Region: Abhydrolase_4; pfam08386 369723003961 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 369723003962 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 369723003963 active site 369723003964 DNA binding site [nucleotide binding] 369723003965 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 369723003966 DNA binding site [nucleotide binding] 369723003967 putative acetyltransferase; Provisional; Region: PRK03624 369723003968 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723003969 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 369723003970 minor groove reading motif; other site 369723003971 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 369723003972 helix-hairpin-helix signature motif; other site 369723003973 active site 369723003974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723003975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 369723003976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723003977 AAA domain; Region: AAA_23; pfam13476 369723003978 Walker A/P-loop; other site 369723003979 ATP binding site [chemical binding]; other site 369723003980 Q-loop/lid; other site 369723003981 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 369723003982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723003983 ABC transporter signature motif; other site 369723003984 Walker B; other site 369723003985 D-loop; other site 369723003986 H-loop/switch region; other site 369723003987 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 369723003988 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 369723003989 active site 369723003990 metal binding site [ion binding]; metal-binding site 369723003991 DNA binding site [nucleotide binding] 369723003992 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 369723003993 HerA helicase [Replication, recombination, and repair]; Region: COG0433 369723003994 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 369723003995 hypothetical protein; Provisional; Region: PRK14059 369723003996 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 369723003997 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 369723003998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723003999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 369723004000 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 369723004001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004002 dimer interface [polypeptide binding]; other site 369723004003 putative PBP binding loops; other site 369723004004 ABC-ATPase subunit interface; other site 369723004005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723004006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004007 dimer interface [polypeptide binding]; other site 369723004008 conserved gate region; other site 369723004009 putative PBP binding loops; other site 369723004010 ABC-ATPase subunit interface; other site 369723004011 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 369723004012 beta-galactosidase; Region: BGL; TIGR03356 369723004013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723004014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723004015 DNA binding site [nucleotide binding] 369723004016 domain linker motif; other site 369723004017 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 369723004018 putative dimerization interface [polypeptide binding]; other site 369723004019 putative ligand binding site [chemical binding]; other site 369723004020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723004021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723004022 active site 369723004023 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 369723004024 putative active site [active] 369723004025 putative substrate binding site [chemical binding]; other site 369723004026 ATP binding site [chemical binding]; other site 369723004027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723004028 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723004029 NAD(P) binding site [chemical binding]; other site 369723004030 catalytic residues [active] 369723004031 biotin synthase; Validated; Region: PRK06256 369723004032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723004033 FeS/SAM binding site; other site 369723004034 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 369723004035 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 369723004036 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 369723004037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723004038 catalytic residue [active] 369723004039 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 369723004040 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723004041 Cytochrome P450; Region: p450; cl12078 369723004042 Predicted methyltransferase [General function prediction only]; Region: COG3897 369723004043 Predicted methyltransferase [General function prediction only]; Region: COG3897 369723004044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723004045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723004046 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 369723004047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723004048 NAD(P) binding site [chemical binding]; other site 369723004049 active site 369723004050 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723004051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723004052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723004053 active site 369723004054 phosphorylation site [posttranslational modification] 369723004055 intermolecular recognition site; other site 369723004056 dimerization interface [polypeptide binding]; other site 369723004057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723004058 DNA binding residues [nucleotide binding] 369723004059 dimerization interface [polypeptide binding]; other site 369723004060 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 369723004061 GAF domain; Region: GAF; pfam01590 369723004062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723004063 Histidine kinase; Region: HisKA_3; pfam07730 369723004064 hypothetical protein; Provisional; Region: PRK07877 369723004065 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 369723004066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 369723004067 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 369723004068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723004069 Ligand Binding Site [chemical binding]; other site 369723004070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723004071 Ligand Binding Site [chemical binding]; other site 369723004072 putative phosphoketolase; Provisional; Region: PRK05261 369723004073 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 369723004074 TPP-binding site; other site 369723004075 XFP C-terminal domain; Region: XFP_C; pfam09363 369723004076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723004077 Ligand Binding Site [chemical binding]; other site 369723004078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723004079 Ligand Binding Site [chemical binding]; other site 369723004080 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 369723004081 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 369723004082 putative active site [active] 369723004083 putative metal binding site [ion binding]; other site 369723004084 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723004085 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723004086 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723004087 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723004088 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723004089 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723004090 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 369723004091 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723004092 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723004093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723004094 non-specific DNA binding site [nucleotide binding]; other site 369723004095 salt bridge; other site 369723004096 sequence-specific DNA binding site [nucleotide binding]; other site 369723004097 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723004098 SpoOM protein; Region: Spo0M; pfam07070 369723004099 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 369723004100 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 369723004101 Part of AAA domain; Region: AAA_19; pfam13245 369723004102 Family description; Region: UvrD_C_2; pfam13538 369723004103 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 369723004104 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 369723004105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723004106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723004107 active site 369723004108 phosphorylation site [posttranslational modification] 369723004109 intermolecular recognition site; other site 369723004110 dimerization interface [polypeptide binding]; other site 369723004111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723004112 DNA binding site [nucleotide binding] 369723004113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723004114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723004115 dimerization interface [polypeptide binding]; other site 369723004116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723004117 dimer interface [polypeptide binding]; other site 369723004118 phosphorylation site [posttranslational modification] 369723004119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723004120 ATP binding site [chemical binding]; other site 369723004121 Mg2+ binding site [ion binding]; other site 369723004122 G-X-G motif; other site 369723004123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 369723004124 Tetratricopeptide repeat; Region: TPR_10; cl17452 369723004125 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723004126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723004127 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 369723004128 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 369723004129 NADP binding site [chemical binding]; other site 369723004130 active site 369723004131 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 369723004132 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 369723004133 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 369723004134 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 369723004135 tetramer interface [polypeptide binding]; other site 369723004136 active site 369723004137 Mg2+/Mn2+ binding site [ion binding]; other site 369723004138 HD domain; Region: HD_3; pfam13023 369723004139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723004140 non-specific DNA binding site [nucleotide binding]; other site 369723004141 salt bridge; other site 369723004142 sequence-specific DNA binding site [nucleotide binding]; other site 369723004143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 369723004144 DsrC like protein; Region: DsrC; pfam04358 369723004145 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 369723004146 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 369723004147 OsmC-like protein; Region: OsmC; pfam02566 369723004148 DDE superfamily endonuclease; Region: DDE_4; cl17710 369723004149 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 369723004150 putative active site [active] 369723004151 putative metal binding site [ion binding]; other site 369723004152 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 369723004153 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 369723004154 Protein of unknown function (DUF664); Region: DUF664; pfam04978 369723004155 DinB superfamily; Region: DinB_2; pfam12867 369723004156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 369723004157 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 369723004158 FMN binding site [chemical binding]; other site 369723004159 substrate binding site [chemical binding]; other site 369723004160 putative catalytic residue [active] 369723004161 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 369723004162 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723004163 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 369723004164 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 369723004165 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 369723004166 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 369723004167 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 369723004168 Walker A/P-loop; other site 369723004169 ATP binding site [chemical binding]; other site 369723004170 Q-loop/lid; other site 369723004171 ABC transporter signature motif; other site 369723004172 Walker B; other site 369723004173 D-loop; other site 369723004174 H-loop/switch region; other site 369723004175 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 369723004176 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723004177 ABC-ATPase subunit interface; other site 369723004178 dimer interface [polypeptide binding]; other site 369723004179 putative PBP binding regions; other site 369723004180 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 369723004181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 369723004182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723004183 ABC-ATPase subunit interface; other site 369723004184 dimer interface [polypeptide binding]; other site 369723004185 putative PBP binding regions; other site 369723004186 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 369723004187 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723004188 intersubunit interface [polypeptide binding]; other site 369723004189 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 369723004190 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 369723004191 active site 369723004192 dimer interface [polypeptide binding]; other site 369723004193 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 369723004194 Ligand Binding Site [chemical binding]; other site 369723004195 Molecular Tunnel; other site 369723004196 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 369723004197 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 369723004198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004199 dimer interface [polypeptide binding]; other site 369723004200 conserved gate region; other site 369723004201 putative PBP binding loops; other site 369723004202 ABC-ATPase subunit interface; other site 369723004203 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 369723004204 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 369723004205 Walker A/P-loop; other site 369723004206 ATP binding site [chemical binding]; other site 369723004207 Q-loop/lid; other site 369723004208 ABC transporter signature motif; other site 369723004209 Walker B; other site 369723004210 D-loop; other site 369723004211 H-loop/switch region; other site 369723004212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 369723004213 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 369723004214 putative PBP binding loops; other site 369723004215 dimer interface [polypeptide binding]; other site 369723004216 ABC-ATPase subunit interface; other site 369723004217 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 369723004218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723004219 UDP-galactopyranose mutase; Region: GLF; pfam03275 369723004220 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 369723004221 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 369723004222 Probable Catalytic site; other site 369723004223 choline dehydrogenase; Validated; Region: PRK02106 369723004224 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 369723004225 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 369723004226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723004227 tetramerization interface [polypeptide binding]; other site 369723004228 NAD(P) binding site [chemical binding]; other site 369723004229 catalytic residues [active] 369723004230 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 369723004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723004232 Walker A/P-loop; other site 369723004233 ATP binding site [chemical binding]; other site 369723004234 Q-loop/lid; other site 369723004235 ABC transporter signature motif; other site 369723004236 Walker B; other site 369723004237 D-loop; other site 369723004238 H-loop/switch region; other site 369723004239 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 369723004240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004241 dimer interface [polypeptide binding]; other site 369723004242 conserved gate region; other site 369723004243 ABC-ATPase subunit interface; other site 369723004244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004245 dimer interface [polypeptide binding]; other site 369723004246 conserved gate region; other site 369723004247 ABC-ATPase subunit interface; other site 369723004248 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 369723004249 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 369723004250 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 369723004251 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 369723004252 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 369723004253 DNA binding residues [nucleotide binding] 369723004254 high affinity sulphate transporter 1; Region: sulP; TIGR00815 369723004255 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 369723004256 Sulfate transporter family; Region: Sulfate_transp; pfam00916 369723004257 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 369723004258 Chitin binding domain; Region: Chitin_bind_3; pfam03067 369723004259 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 369723004260 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 369723004261 Domain of unknown function (DUF305); Region: DUF305; cl17794 369723004262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723004263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723004264 DNA binding residues [nucleotide binding] 369723004265 dimerization interface [polypeptide binding]; other site 369723004266 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 369723004267 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 369723004268 nucleotide binding site [chemical binding]; other site 369723004269 putative NEF/HSP70 interaction site [polypeptide binding]; other site 369723004270 SBD interface [polypeptide binding]; other site 369723004271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 369723004272 Dynamin family; Region: Dynamin_N; pfam00350 369723004273 G1 box; other site 369723004274 GTP/Mg2+ binding site [chemical binding]; other site 369723004275 G2 box; other site 369723004276 Switch I region; other site 369723004277 G3 box; other site 369723004278 Switch II region; other site 369723004279 G4 box; other site 369723004280 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 369723004281 Dynamin family; Region: Dynamin_N; pfam00350 369723004282 G1 box; other site 369723004283 GTP/Mg2+ binding site [chemical binding]; other site 369723004284 G2 box; other site 369723004285 Switch I region; other site 369723004286 G3 box; other site 369723004287 Switch II region; other site 369723004288 G4 box; other site 369723004289 G5 box; other site 369723004290 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 369723004291 iron-sulfur cluster [ion binding]; other site 369723004292 [2Fe-2S] cluster binding site [ion binding]; other site 369723004293 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 369723004294 cyclase homology domain; Region: CHD; cd07302 369723004295 nucleotidyl binding site; other site 369723004296 metal binding site [ion binding]; metal-binding site 369723004297 dimer interface [polypeptide binding]; other site 369723004298 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 369723004299 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 369723004300 ligand binding site [chemical binding]; other site 369723004301 flexible hinge region; other site 369723004302 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 369723004303 putative switch regulator; other site 369723004304 non-specific DNA interactions [nucleotide binding]; other site 369723004305 DNA binding site [nucleotide binding] 369723004306 sequence specific DNA binding site [nucleotide binding]; other site 369723004307 putative cAMP binding site [chemical binding]; other site 369723004308 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 369723004309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723004310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723004311 non-specific DNA binding site [nucleotide binding]; other site 369723004312 salt bridge; other site 369723004313 sequence-specific DNA binding site [nucleotide binding]; other site 369723004314 Transposase; Region: DEDD_Tnp_IS110; pfam01548 369723004315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723004316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723004317 metal binding site [ion binding]; metal-binding site 369723004318 active site 369723004319 I-site; other site 369723004320 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 369723004321 Thioredoxin; Region: Thioredoxin_4; pfam13462 369723004322 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 369723004323 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 369723004324 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 369723004325 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 369723004326 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 369723004327 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 369723004328 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723004329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004330 dimer interface [polypeptide binding]; other site 369723004331 conserved gate region; other site 369723004332 putative PBP binding loops; other site 369723004333 ABC-ATPase subunit interface; other site 369723004334 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 369723004335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723004336 dimer interface [polypeptide binding]; other site 369723004337 conserved gate region; other site 369723004338 putative PBP binding loops; other site 369723004339 ABC-ATPase subunit interface; other site 369723004340 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 369723004341 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723004342 Walker A/P-loop; other site 369723004343 ATP binding site [chemical binding]; other site 369723004344 Q-loop/lid; other site 369723004345 ABC transporter signature motif; other site 369723004346 Walker B; other site 369723004347 D-loop; other site 369723004348 H-loop/switch region; other site 369723004349 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 369723004350 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 369723004351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723004352 Walker A/P-loop; other site 369723004353 ATP binding site [chemical binding]; other site 369723004354 Q-loop/lid; other site 369723004355 ABC transporter signature motif; other site 369723004356 Walker B; other site 369723004357 D-loop; other site 369723004358 H-loop/switch region; other site 369723004359 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 369723004360 Cation efflux family; Region: Cation_efflux; cl00316 369723004361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723004362 dimerization interface [polypeptide binding]; other site 369723004363 putative DNA binding site [nucleotide binding]; other site 369723004364 putative Zn2+ binding site [ion binding]; other site 369723004365 SCP-2 sterol transfer family; Region: SCP2; pfam02036 369723004366 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 369723004367 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 369723004368 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 369723004369 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 369723004370 active site 369723004371 oxyanion hole [active] 369723004372 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 369723004373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723004374 ATP binding site [chemical binding]; other site 369723004375 Mg2+ binding site [ion binding]; other site 369723004376 G-X-G motif; other site 369723004377 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 369723004378 anchoring element; other site 369723004379 dimer interface [polypeptide binding]; other site 369723004380 ATP binding site [chemical binding]; other site 369723004381 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 369723004382 active site 369723004383 metal binding site [ion binding]; metal-binding site 369723004384 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 369723004385 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 369723004386 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 369723004387 CAP-like domain; other site 369723004388 active site 369723004389 primary dimer interface [polypeptide binding]; other site 369723004390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 369723004391 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 369723004392 putative active site [active] 369723004393 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 369723004394 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 369723004395 substrate binding site; other site 369723004396 dimer interface; other site 369723004397 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 369723004398 classical (c) SDRs; Region: SDR_c; cd05233 369723004399 NAD(P) binding site [chemical binding]; other site 369723004400 active site 369723004401 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 369723004402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723004403 Walker A/P-loop; other site 369723004404 ATP binding site [chemical binding]; other site 369723004405 Q-loop/lid; other site 369723004406 ABC transporter signature motif; other site 369723004407 Walker B; other site 369723004408 D-loop; other site 369723004409 H-loop/switch region; other site 369723004410 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 369723004411 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 369723004412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723004413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723004414 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 369723004415 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 369723004416 inhibitor-cofactor binding pocket; inhibition site 369723004417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723004418 catalytic residue [active] 369723004419 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 369723004420 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723004421 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 369723004422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723004423 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723004424 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723004425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723004426 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 369723004427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723004428 active site 369723004429 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 369723004430 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 369723004431 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 369723004432 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 369723004433 putative trimer interface [polypeptide binding]; other site 369723004434 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 369723004435 putative CoA binding site [chemical binding]; other site 369723004436 putative trimer interface [polypeptide binding]; other site 369723004437 putative active site [active] 369723004438 putative substrate binding site [chemical binding]; other site 369723004439 putative CoA binding site [chemical binding]; other site 369723004440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723004441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723004442 active site 369723004443 dimerization interface [polypeptide binding]; other site 369723004444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723004445 DNA binding site [nucleotide binding] 369723004446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723004447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723004448 dimerization interface [polypeptide binding]; other site 369723004449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723004450 dimer interface [polypeptide binding]; other site 369723004451 phosphorylation site [posttranslational modification] 369723004452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723004453 ATP binding site [chemical binding]; other site 369723004454 Mg2+ binding site [ion binding]; other site 369723004455 G-X-G motif; other site 369723004456 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 369723004457 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 369723004458 Uncharacterized conserved protein [Function unknown]; Region: COG4850 369723004459 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 369723004460 phosphoglucomutase; Validated; Region: PRK07564 369723004461 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 369723004462 active site 369723004463 substrate binding site [chemical binding]; other site 369723004464 metal binding site [ion binding]; metal-binding site 369723004465 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 369723004466 ATP-NAD kinase; Region: NAD_kinase; pfam01513 369723004467 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 369723004468 putative active site [active] 369723004469 Zn binding site [ion binding]; other site 369723004470 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 369723004471 RibD C-terminal domain; Region: RibD_C; cl17279 369723004472 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 369723004473 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 369723004474 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 369723004475 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 369723004476 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 369723004477 RNA binding site [nucleotide binding]; other site 369723004478 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723004479 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 369723004480 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 369723004481 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 369723004482 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 369723004483 L-aspartate oxidase; Provisional; Region: PRK06175 369723004484 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 369723004485 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 369723004486 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 369723004487 putative Iron-sulfur protein interface [polypeptide binding]; other site 369723004488 proximal heme binding site [chemical binding]; other site 369723004489 distal heme binding site [chemical binding]; other site 369723004490 putative dimer interface [polypeptide binding]; other site 369723004491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723004492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723004493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 369723004494 dimerization interface [polypeptide binding]; other site 369723004495 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 369723004496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723004497 ATP binding site [chemical binding]; other site 369723004498 putative Mg++ binding site [ion binding]; other site 369723004499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723004500 nucleotide binding region [chemical binding]; other site 369723004501 ATP-binding site [chemical binding]; other site 369723004502 Helicase associated domain (HA2); Region: HA2; pfam04408 369723004503 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 369723004504 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 369723004505 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 369723004506 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 369723004507 potential catalytic triad [active] 369723004508 conserved cys residue [active] 369723004509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723004510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723004511 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 369723004512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723004513 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723004514 NAD(P) binding site [chemical binding]; other site 369723004515 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 369723004516 hypothetical protein; Provisional; Region: PRK07505 369723004517 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 369723004518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723004519 catalytic residue [active] 369723004520 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 369723004521 putative active site [active] 369723004522 putative catalytic site [active] 369723004523 aconitate hydratase-like protein; Provisional; Region: PTZ00092 369723004524 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 369723004525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723004526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723004527 catalytic residue [active] 369723004528 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 369723004529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723004530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723004531 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723004532 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 369723004533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 369723004534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 369723004535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 369723004536 dimerization interface [polypeptide binding]; other site 369723004537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723004538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723004539 ATP binding site [chemical binding]; other site 369723004540 putative Mg++ binding site [ion binding]; other site 369723004541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723004542 nucleotide binding region [chemical binding]; other site 369723004543 ATP-binding site [chemical binding]; other site 369723004544 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 369723004545 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 369723004546 active site 369723004547 putative catalytic site [active] 369723004548 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 369723004549 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 369723004550 putative catalytic site [active] 369723004551 putative phosphate binding site [ion binding]; other site 369723004552 active site 369723004553 metal binding site A [ion binding]; metal-binding site 369723004554 DNA binding site [nucleotide binding] 369723004555 putative AP binding site [nucleotide binding]; other site 369723004556 putative metal binding site B [ion binding]; other site 369723004557 PAC2 family; Region: PAC2; pfam09754 369723004558 EcsC protein family; Region: EcsC; pfam12787 369723004559 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 369723004560 active site 369723004561 catalytic triad [active] 369723004562 oxyanion hole [active] 369723004563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 369723004564 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723004565 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 369723004566 NAD(P) binding site [chemical binding]; other site 369723004567 catalytic residues [active] 369723004568 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 369723004569 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 369723004570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723004571 ATP binding site [chemical binding]; other site 369723004572 putative Mg++ binding site [ion binding]; other site 369723004573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 369723004574 nucleotide binding region [chemical binding]; other site 369723004575 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 369723004576 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 369723004577 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723004578 Helix-turn-helix domain; Region: HTH_31; pfam13560 369723004579 Amino acid permease; Region: AA_permease; pfam00324 369723004580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723004581 Coenzyme A binding pocket [chemical binding]; other site 369723004582 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 369723004583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723004584 Conserved TM helix; Region: TM_helix; pfam05552 369723004585 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 369723004586 putative hydrophobic ligand binding site [chemical binding]; other site 369723004587 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 369723004588 ChaB; Region: ChaB; pfam06150 369723004589 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 369723004590 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723004591 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 369723004592 NAD(P) binding site [chemical binding]; other site 369723004593 catalytic residues [active] 369723004594 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 369723004595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723004596 hydroxyglutarate oxidase; Provisional; Region: PRK11728 369723004597 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 369723004598 Ligand binding site; other site 369723004599 Putative Catalytic site; other site 369723004600 DXD motif; other site 369723004601 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 369723004602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723004603 active site 369723004604 motif I; other site 369723004605 motif II; other site 369723004606 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 369723004607 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 369723004608 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 369723004609 putative active site [active] 369723004610 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 369723004611 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 369723004612 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 369723004613 putative ADP-binding pocket [chemical binding]; other site 369723004614 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 369723004615 dimer interface [polypeptide binding]; other site 369723004616 active site 369723004617 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 369723004618 substrate binding site [chemical binding]; other site 369723004619 ATP binding site [chemical binding]; other site 369723004620 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 369723004621 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 369723004622 active site 369723004623 nucleotide binding site [chemical binding]; other site 369723004624 HIGH motif; other site 369723004625 KMSKS motif; other site 369723004626 classical (c) SDRs; Region: SDR_c; cd05233 369723004627 NAD(P) binding site [chemical binding]; other site 369723004628 active site 369723004629 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 369723004630 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 369723004631 putative active site [active] 369723004632 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 369723004633 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 369723004634 active site 369723004635 DNA binding site [nucleotide binding] 369723004636 Int/Topo IB signature motif; other site 369723004637 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 369723004638 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 369723004639 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 369723004640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723004641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723004642 catalytic residue [active] 369723004643 Mechanosensitive ion channel; Region: MS_channel; pfam00924 369723004644 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 369723004645 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 369723004646 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723004647 DNA-binding site [nucleotide binding]; DNA binding site 369723004648 RNA-binding motif; other site 369723004649 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723004650 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723004651 active site 369723004652 catalytic tetrad [active] 369723004653 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 369723004654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723004655 S-adenosylmethionine binding site [chemical binding]; other site 369723004656 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 369723004657 adenosine deaminase; Provisional; Region: PRK09358 369723004658 active site 369723004659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723004660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723004661 dimer interface [polypeptide binding]; other site 369723004662 phosphorylation site [posttranslational modification] 369723004663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723004664 ATP binding site [chemical binding]; other site 369723004665 Mg2+ binding site [ion binding]; other site 369723004666 G-X-G motif; other site 369723004667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723004668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723004669 active site 369723004670 phosphorylation site [posttranslational modification] 369723004671 intermolecular recognition site; other site 369723004672 dimerization interface [polypeptide binding]; other site 369723004673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723004674 DNA binding site [nucleotide binding] 369723004675 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 369723004676 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 369723004677 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 369723004678 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 369723004679 active site 369723004680 dimer interface [polypeptide binding]; other site 369723004681 motif 1; other site 369723004682 motif 2; other site 369723004683 motif 3; other site 369723004684 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 369723004685 anticodon binding site; other site 369723004686 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 369723004687 nucleotide binding site/active site [active] 369723004688 HIT family signature motif; other site 369723004689 catalytic residue [active] 369723004690 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 369723004691 elongation factor G; Reviewed; Region: PRK12740 369723004692 G1 box; other site 369723004693 putative GEF interaction site [polypeptide binding]; other site 369723004694 GTP/Mg2+ binding site [chemical binding]; other site 369723004695 Switch I region; other site 369723004696 G2 box; other site 369723004697 G3 box; other site 369723004698 Switch II region; other site 369723004699 G4 box; other site 369723004700 G5 box; other site 369723004701 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 369723004702 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 369723004703 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 369723004704 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 369723004705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 369723004706 putative acyl-acceptor binding pocket; other site 369723004707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723004708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723004709 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 369723004710 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 369723004711 active site 369723004712 multimer interface [polypeptide binding]; other site 369723004713 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 369723004714 predicted active site [active] 369723004715 catalytic triad [active] 369723004716 hypothetical protein; Validated; Region: PRK00110 369723004717 prolyl-tRNA synthetase; Provisional; Region: PRK09194 369723004718 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723004719 motif 1; other site 369723004720 dimer interface [polypeptide binding]; other site 369723004721 active site 369723004722 motif 2; other site 369723004723 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 369723004724 putative deacylase active site [active] 369723004725 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723004726 active site 369723004727 motif 3; other site 369723004728 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 369723004729 anticodon binding site; other site 369723004730 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 369723004731 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 369723004732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723004733 Walker A/P-loop; other site 369723004734 ATP binding site [chemical binding]; other site 369723004735 Q-loop/lid; other site 369723004736 ABC transporter signature motif; other site 369723004737 Walker B; other site 369723004738 D-loop; other site 369723004739 H-loop/switch region; other site 369723004740 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 369723004741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723004742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723004743 active site 369723004744 phosphorylation site [posttranslational modification] 369723004745 intermolecular recognition site; other site 369723004746 dimerization interface [polypeptide binding]; other site 369723004747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723004748 DNA binding residues [nucleotide binding] 369723004749 dimerization interface [polypeptide binding]; other site 369723004750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723004751 Histidine kinase; Region: HisKA_3; pfam07730 369723004752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723004753 ATP binding site [chemical binding]; other site 369723004754 Mg2+ binding site [ion binding]; other site 369723004755 G-X-G motif; other site 369723004756 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 369723004757 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 369723004758 active site 369723004759 PHP Thumb interface [polypeptide binding]; other site 369723004760 metal binding site [ion binding]; metal-binding site 369723004761 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 369723004762 generic binding surface II; other site 369723004763 generic binding surface I; other site 369723004764 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723004765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723004766 catalytic residue [active] 369723004767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723004768 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 369723004769 nucleophilic elbow; other site 369723004770 catalytic triad; other site 369723004771 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 369723004772 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 369723004773 Walker A/P-loop; other site 369723004774 ATP binding site [chemical binding]; other site 369723004775 Q-loop/lid; other site 369723004776 ABC transporter signature motif; other site 369723004777 Walker B; other site 369723004778 D-loop; other site 369723004779 H-loop/switch region; other site 369723004780 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 369723004781 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 369723004782 Walker A/P-loop; other site 369723004783 ATP binding site [chemical binding]; other site 369723004784 Q-loop/lid; other site 369723004785 ABC transporter signature motif; other site 369723004786 Walker B; other site 369723004787 D-loop; other site 369723004788 H-loop/switch region; other site 369723004789 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 369723004790 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 369723004791 putative ligand binding site [chemical binding]; other site 369723004792 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 369723004793 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723004794 TM-ABC transporter signature motif; other site 369723004795 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 369723004796 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 369723004797 TM-ABC transporter signature motif; other site 369723004798 GAF domain; Region: GAF; pfam01590 369723004799 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 369723004800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723004801 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 369723004802 NAD(P) binding site [chemical binding]; other site 369723004803 active site 369723004804 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 369723004805 active site 369723004806 dimer interface [polypeptide binding]; other site 369723004807 putative DNA-binding cleft [nucleotide binding]; other site 369723004808 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 369723004809 RuvA N terminal domain; Region: RuvA_N; pfam01330 369723004810 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 369723004811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723004812 Walker A motif; other site 369723004813 ATP binding site [chemical binding]; other site 369723004814 Walker B motif; other site 369723004815 arginine finger; other site 369723004816 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 369723004817 Preprotein translocase subunit; Region: YajC; pfam02699 369723004818 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 369723004819 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 369723004820 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 369723004821 Protein export membrane protein; Region: SecD_SecF; pfam02355 369723004822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723004823 active site 369723004824 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 369723004825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 369723004826 Zn2+ binding site [ion binding]; other site 369723004827 Mg2+ binding site [ion binding]; other site 369723004828 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 369723004829 synthetase active site [active] 369723004830 NTP binding site [chemical binding]; other site 369723004831 metal binding site [ion binding]; metal-binding site 369723004832 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 369723004833 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 369723004834 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 369723004835 active site 369723004836 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 369723004837 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 369723004838 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 369723004839 dimer interface [polypeptide binding]; other site 369723004840 motif 1; other site 369723004841 active site 369723004842 motif 2; other site 369723004843 motif 3; other site 369723004844 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 369723004845 anticodon binding site; other site 369723004846 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 369723004847 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 369723004848 homodimer interface [polypeptide binding]; other site 369723004849 putative substrate binding pocket [chemical binding]; other site 369723004850 diiron center [ion binding]; other site 369723004851 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 369723004852 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 369723004853 dimer interface [polypeptide binding]; other site 369723004854 anticodon binding site; other site 369723004855 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 369723004856 homodimer interface [polypeptide binding]; other site 369723004857 motif 1; other site 369723004858 active site 369723004859 motif 2; other site 369723004860 GAD domain; Region: GAD; pfam02938 369723004861 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 369723004862 motif 3; other site 369723004863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723004864 putative DNA binding site [nucleotide binding]; other site 369723004865 dimerization interface [polypeptide binding]; other site 369723004866 putative Zn2+ binding site [ion binding]; other site 369723004867 recombination factor protein RarA; Reviewed; Region: PRK13342 369723004868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723004869 Walker A motif; other site 369723004870 ATP binding site [chemical binding]; other site 369723004871 Walker B motif; other site 369723004872 arginine finger; other site 369723004873 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 369723004874 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 369723004875 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 369723004876 motif 1; other site 369723004877 active site 369723004878 motif 2; other site 369723004879 motif 3; other site 369723004880 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 369723004881 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 369723004882 YceG-like family; Region: YceG; pfam02618 369723004883 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 369723004884 dimerization interface [polypeptide binding]; other site 369723004885 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 369723004886 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 369723004887 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 369723004888 NAD(P) binding site [chemical binding]; other site 369723004889 shikimate binding site; other site 369723004890 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 369723004891 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 369723004892 trimer interface [polypeptide binding]; other site 369723004893 active site 369723004894 substrate binding site [chemical binding]; other site 369723004895 CoA binding site [chemical binding]; other site 369723004896 O-Antigen ligase; Region: Wzy_C; cl04850 369723004897 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 369723004898 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 369723004899 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 369723004900 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 369723004901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723004902 active site 369723004903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723004904 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 369723004905 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 369723004906 potassium/proton antiporter; Reviewed; Region: PRK05326 369723004907 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 369723004908 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 369723004909 Tetramer interface [polypeptide binding]; other site 369723004910 active site 369723004911 FMN-binding site [chemical binding]; other site 369723004912 shikimate kinase; Reviewed; Region: aroK; PRK00131 369723004913 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 369723004914 ADP binding site [chemical binding]; other site 369723004915 magnesium binding site [ion binding]; other site 369723004916 putative shikimate binding site; other site 369723004917 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 369723004918 dimer interface [polypeptide binding]; other site 369723004919 active site 369723004920 metal binding site [ion binding]; metal-binding site 369723004921 Dehydroquinase class II; Region: DHquinase_II; pfam01220 369723004922 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 369723004923 trimer interface [polypeptide binding]; other site 369723004924 active site 369723004925 dimer interface [polypeptide binding]; other site 369723004926 elongation factor P; Validated; Region: PRK00529 369723004927 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 369723004928 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 369723004929 RNA binding site [nucleotide binding]; other site 369723004930 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 369723004931 RNA binding site [nucleotide binding]; other site 369723004932 transcription antitermination factor NusB; Region: nusB; TIGR01951 369723004933 putative RNA binding site [nucleotide binding]; other site 369723004934 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723004935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723004936 non-specific DNA binding site [nucleotide binding]; other site 369723004937 salt bridge; other site 369723004938 sequence-specific DNA binding site [nucleotide binding]; other site 369723004939 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 369723004940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723004941 active site 369723004942 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 369723004943 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 369723004944 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 369723004945 dihydroorotase; Validated; Region: pyrC; PRK09357 369723004946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723004947 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 369723004948 active site 369723004949 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 369723004950 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 369723004951 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 369723004952 catalytic site [active] 369723004953 subunit interface [polypeptide binding]; other site 369723004954 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 369723004955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723004956 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723004957 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 369723004958 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723004959 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723004960 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 369723004961 IMP binding site; other site 369723004962 dimer interface [polypeptide binding]; other site 369723004963 interdomain contacts; other site 369723004964 partial ornithine binding site; other site 369723004965 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 369723004966 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 369723004967 quinone interaction residues [chemical binding]; other site 369723004968 active site 369723004969 catalytic residues [active] 369723004970 FMN binding site [chemical binding]; other site 369723004971 substrate binding site [chemical binding]; other site 369723004972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723004973 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 369723004974 inhibitor-cofactor binding pocket; inhibition site 369723004975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723004976 catalytic residue [active] 369723004977 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 369723004978 active site 369723004979 dimer interface [polypeptide binding]; other site 369723004980 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 369723004981 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 369723004982 active site 369723004983 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 369723004984 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 369723004985 Flavoprotein; Region: Flavoprotein; pfam02441 369723004986 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 369723004987 S-adenosylmethionine synthetase; Validated; Region: PRK05250 369723004988 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 369723004989 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 369723004990 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 369723004991 primosome assembly protein PriA; Provisional; Region: PRK14873 369723004992 cytidylate kinase; Provisional; Region: PRK04182 369723004993 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 369723004994 CMP-binding site; other site 369723004995 The sites determining sugar specificity; other site 369723004996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723004997 Cytochrome P450; Region: p450; cl12078 369723004998 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 369723004999 active site 369723005000 catalytic residues [active] 369723005001 metal binding site [ion binding]; metal-binding site 369723005002 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 369723005003 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 369723005004 putative active site [active] 369723005005 substrate binding site [chemical binding]; other site 369723005006 putative cosubstrate binding site; other site 369723005007 catalytic site [active] 369723005008 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 369723005009 substrate binding site [chemical binding]; other site 369723005010 16S rRNA methyltransferase B; Provisional; Region: PRK14902 369723005011 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 369723005012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723005013 S-adenosylmethionine binding site [chemical binding]; other site 369723005014 Septum formation; Region: Septum_form; pfam13845 369723005015 Septum formation; Region: Septum_form; pfam13845 369723005016 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 369723005017 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 369723005018 substrate binding site [chemical binding]; other site 369723005019 hexamer interface [polypeptide binding]; other site 369723005020 metal binding site [ion binding]; metal-binding site 369723005021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723005022 active site 369723005023 phosphorylation site [posttranslational modification] 369723005024 intermolecular recognition site; other site 369723005025 dimerization interface [polypeptide binding]; other site 369723005026 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723005027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723005028 metal binding site [ion binding]; metal-binding site 369723005029 active site 369723005030 I-site; other site 369723005031 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 369723005032 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 369723005033 catalytic motif [active] 369723005034 Zn binding site [ion binding]; other site 369723005035 RibD C-terminal domain; Region: RibD_C; cl17279 369723005036 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 369723005037 Lumazine binding domain; Region: Lum_binding; pfam00677 369723005038 Lumazine binding domain; Region: Lum_binding; pfam00677 369723005039 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 369723005040 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 369723005041 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 369723005042 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 369723005043 dimerization interface [polypeptide binding]; other site 369723005044 active site 369723005045 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 369723005046 homopentamer interface [polypeptide binding]; other site 369723005047 active site 369723005048 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 369723005049 homodimer interface [polypeptide binding]; other site 369723005050 putative metal binding site [ion binding]; other site 369723005051 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 369723005052 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 369723005053 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 369723005054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 369723005055 translation initiation factor IF-3; Region: infC; TIGR00168 369723005056 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 369723005057 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 369723005058 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 369723005059 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 369723005060 23S rRNA binding site [nucleotide binding]; other site 369723005061 L21 binding site [polypeptide binding]; other site 369723005062 L13 binding site [polypeptide binding]; other site 369723005063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 369723005064 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 369723005065 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 369723005066 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 369723005067 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 369723005068 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 369723005069 dimer interface [polypeptide binding]; other site 369723005070 motif 1; other site 369723005071 active site 369723005072 motif 2; other site 369723005073 motif 3; other site 369723005074 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 369723005075 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 369723005076 putative tRNA-binding site [nucleotide binding]; other site 369723005077 B3/4 domain; Region: B3_4; pfam03483 369723005078 tRNA synthetase B5 domain; Region: B5; smart00874 369723005079 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723005080 motif 1; other site 369723005081 dimer interface [polypeptide binding]; other site 369723005082 active site 369723005083 motif 2; other site 369723005084 motif 3; other site 369723005085 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 369723005086 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 369723005087 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 369723005088 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 369723005089 heterotetramer interface [polypeptide binding]; other site 369723005090 active site pocket [active] 369723005091 cleavage site 369723005092 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 369723005093 feedback inhibition sensing region; other site 369723005094 homohexameric interface [polypeptide binding]; other site 369723005095 nucleotide binding site [chemical binding]; other site 369723005096 N-acetyl-L-glutamate binding site [chemical binding]; other site 369723005097 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 369723005098 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723005099 inhibitor-cofactor binding pocket; inhibition site 369723005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723005101 catalytic residue [active] 369723005102 ornithine carbamoyltransferase; Provisional; Region: PRK00779 369723005103 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 369723005104 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 369723005105 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 369723005106 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 369723005107 argininosuccinate synthase; Provisional; Region: PRK13820 369723005108 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 369723005109 ANP binding site [chemical binding]; other site 369723005110 Substrate Binding Site II [chemical binding]; other site 369723005111 Substrate Binding Site I [chemical binding]; other site 369723005112 argininosuccinate lyase; Provisional; Region: PRK00855 369723005113 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 369723005114 active sites [active] 369723005115 tetramer interface [polypeptide binding]; other site 369723005116 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 369723005117 active site 369723005118 DNA binding site [nucleotide binding] 369723005119 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723005120 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 369723005121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723005122 Ligand Binding Site [chemical binding]; other site 369723005123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723005124 Ligand Binding Site [chemical binding]; other site 369723005125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723005126 Ligand Binding Site [chemical binding]; other site 369723005127 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723005128 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723005129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723005130 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 369723005131 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 369723005132 CoenzymeA binding site [chemical binding]; other site 369723005133 subunit interaction site [polypeptide binding]; other site 369723005134 PHB binding site; other site 369723005135 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 369723005136 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 369723005137 active site 369723005138 HIGH motif; other site 369723005139 dimer interface [polypeptide binding]; other site 369723005140 KMSKS motif; other site 369723005141 S4 RNA-binding domain; Region: S4; smart00363 369723005142 RNA binding surface [nucleotide binding]; other site 369723005143 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 369723005144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723005145 active site 369723005146 motif I; other site 369723005147 motif II; other site 369723005148 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 369723005149 SCP-2 sterol transfer family; Region: SCP2; pfam02036 369723005150 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 369723005151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 369723005152 RNA binding surface [nucleotide binding]; other site 369723005153 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 369723005154 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 369723005155 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 369723005156 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 369723005157 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 369723005158 Walker A/P-loop; other site 369723005159 ATP binding site [chemical binding]; other site 369723005160 Q-loop/lid; other site 369723005161 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 369723005162 ABC transporter signature motif; other site 369723005163 Walker B; other site 369723005164 D-loop; other site 369723005165 H-loop/switch region; other site 369723005166 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 369723005167 Thiamine pyrophosphokinase; Region: TPK; cl08415 369723005168 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 369723005169 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 369723005170 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723005171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723005172 CTP synthetase; Validated; Region: pyrG; PRK05380 369723005173 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 369723005174 Catalytic site [active] 369723005175 active site 369723005176 UTP binding site [chemical binding]; other site 369723005177 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 369723005178 active site 369723005179 putative oxyanion hole; other site 369723005180 catalytic triad [active] 369723005181 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 369723005182 dimer interface [polypeptide binding]; other site 369723005183 ADP-ribose binding site [chemical binding]; other site 369723005184 active site 369723005185 nudix motif; other site 369723005186 metal binding site [ion binding]; metal-binding site 369723005187 TM2 domain; Region: TM2; pfam05154 369723005188 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 369723005189 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 369723005190 hexamer interface [polypeptide binding]; other site 369723005191 ligand binding site [chemical binding]; other site 369723005192 putative active site [active] 369723005193 NAD(P) binding site [chemical binding]; other site 369723005194 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 369723005195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723005196 active site 369723005197 DNA binding site [nucleotide binding] 369723005198 Int/Topo IB signature motif; other site 369723005199 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 369723005200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 369723005201 P-loop; other site 369723005202 Magnesium ion binding site [ion binding]; other site 369723005203 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 369723005204 Magnesium ion binding site [ion binding]; other site 369723005205 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 369723005206 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 369723005207 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 369723005208 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 369723005209 RNA binding surface [nucleotide binding]; other site 369723005210 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 369723005211 active site 369723005212 cytidylate kinase; Provisional; Region: cmk; PRK00023 369723005213 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 369723005214 CMP-binding site; other site 369723005215 The sites determining sugar specificity; other site 369723005216 GTP-binding protein Der; Reviewed; Region: PRK03003 369723005217 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 369723005218 G1 box; other site 369723005219 GTP/Mg2+ binding site [chemical binding]; other site 369723005220 Switch I region; other site 369723005221 G2 box; other site 369723005222 Switch II region; other site 369723005223 G3 box; other site 369723005224 G4 box; other site 369723005225 G5 box; other site 369723005226 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 369723005227 G1 box; other site 369723005228 GTP/Mg2+ binding site [chemical binding]; other site 369723005229 G2 box; other site 369723005230 Switch I region; other site 369723005231 G3 box; other site 369723005232 Switch II region; other site 369723005233 G4 box; other site 369723005234 G5 box; other site 369723005235 Phage integrase family; Region: Phage_integrase; pfam00589 369723005236 active site 369723005237 DNA binding site [nucleotide binding] 369723005238 Int/Topo IB signature motif; other site 369723005239 Integrase core domain; Region: rve; pfam00665 369723005240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 369723005241 Transposase; Region: HTH_Tnp_1; cl17663 369723005242 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723005243 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723005244 active site 369723005245 DNA binding site [nucleotide binding] 369723005246 Int/Topo IB signature motif; other site 369723005247 DDE superfamily endonuclease; Region: DDE_5; pfam13546 369723005248 DDE superfamily endonuclease; Region: DDE_5; cl17874 369723005249 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 369723005250 Ycf46; Provisional; Region: ycf46; CHL00195 369723005251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723005252 Walker A motif; other site 369723005253 ATP binding site [chemical binding]; other site 369723005254 Walker B motif; other site 369723005255 arginine finger; other site 369723005256 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 369723005257 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 369723005258 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 369723005259 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 369723005260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 369723005261 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723005262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 369723005263 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 369723005264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723005265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723005266 DNA binding residues [nucleotide binding] 369723005267 dimerization interface [polypeptide binding]; other site 369723005268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 369723005270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005271 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 369723005272 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 369723005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723005274 NAD(P) binding site [chemical binding]; other site 369723005275 active site 369723005276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 369723005277 Rhodanese-like domain; Region: Rhodanese; pfam00581 369723005278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 369723005279 active site residue [active] 369723005280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 369723005281 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 369723005282 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 369723005283 putative ligand binding residues [chemical binding]; other site 369723005284 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 369723005285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723005286 Walker A/P-loop; other site 369723005287 ATP binding site [chemical binding]; other site 369723005288 Q-loop/lid; other site 369723005289 ABC transporter signature motif; other site 369723005290 Walker B; other site 369723005291 D-loop; other site 369723005292 H-loop/switch region; other site 369723005293 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 369723005294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723005295 putative PBP binding regions; other site 369723005296 ABC-ATPase subunit interface; other site 369723005297 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005298 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723005299 active site 369723005300 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 369723005301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723005302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723005304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005305 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005306 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005307 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723005309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723005310 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723005311 DNA binding site [nucleotide binding] 369723005312 active site 369723005313 Int/Topo IB signature motif; other site 369723005314 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 369723005315 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 369723005316 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 369723005317 catalytic residues [active] 369723005318 catalytic nucleophile [active] 369723005319 Presynaptic Site I dimer interface [polypeptide binding]; other site 369723005320 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 369723005321 Synaptic Flat tetramer interface [polypeptide binding]; other site 369723005322 Synaptic Site I dimer interface [polypeptide binding]; other site 369723005323 DNA binding site [nucleotide binding] 369723005324 Recombinase; Region: Recombinase; pfam07508 369723005325 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 369723005326 Replication-relaxation; Region: Replic_Relax; pfam13814 369723005327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723005328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723005329 non-specific DNA binding site [nucleotide binding]; other site 369723005330 salt bridge; other site 369723005331 sequence-specific DNA binding site [nucleotide binding]; other site 369723005332 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723005333 nudix motif; other site 369723005334 substrate binding pocket [chemical binding]; other site 369723005335 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 369723005336 active site 369723005337 iron coordination sites [ion binding]; other site 369723005338 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 369723005339 active site 369723005340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723005341 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 369723005342 FeS/SAM binding site; other site 369723005343 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 369723005344 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 369723005345 nudix motif; other site 369723005346 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 369723005347 substrate binding site [chemical binding]; other site 369723005348 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723005349 ATP binding site [chemical binding]; other site 369723005350 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 369723005351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723005352 motif II; other site 369723005353 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 369723005354 putative metal binding site [ion binding]; other site 369723005355 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 369723005356 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 369723005357 active site 369723005358 Ca binding site [ion binding]; other site 369723005359 catalytic site [active] 369723005360 Aamy_C domain; Region: Aamy_C; smart00632 369723005361 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 369723005362 starch-binding site 2 [chemical binding]; other site 369723005363 starch-binding site 1 [chemical binding]; other site 369723005364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 369723005365 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 369723005366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723005367 dimer interface [polypeptide binding]; other site 369723005368 conserved gate region; other site 369723005369 putative PBP binding loops; other site 369723005370 ABC-ATPase subunit interface; other site 369723005371 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 369723005372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723005373 Walker A/P-loop; other site 369723005374 ATP binding site [chemical binding]; other site 369723005375 Q-loop/lid; other site 369723005376 ABC transporter signature motif; other site 369723005377 Walker B; other site 369723005378 D-loop; other site 369723005379 H-loop/switch region; other site 369723005380 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 369723005381 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 369723005382 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 369723005383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723005384 motif II; other site 369723005385 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 369723005386 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723005388 DNA-binding site [nucleotide binding]; DNA binding site 369723005389 UTRA domain; Region: UTRA; pfam07702 369723005390 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 369723005391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723005392 dimerization interface [polypeptide binding]; other site 369723005393 putative DNA binding site [nucleotide binding]; other site 369723005394 putative Zn2+ binding site [ion binding]; other site 369723005395 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 369723005396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 369723005397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 369723005398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723005399 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 369723005400 Walker A/P-loop; other site 369723005401 ATP binding site [chemical binding]; other site 369723005402 Q-loop/lid; other site 369723005403 ABC transporter signature motif; other site 369723005404 Walker B; other site 369723005405 D-loop; other site 369723005406 H-loop/switch region; other site 369723005407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723005408 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 369723005409 metal ion-dependent adhesion site (MIDAS); other site 369723005410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723005411 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 369723005412 Walker A motif; other site 369723005413 ATP binding site [chemical binding]; other site 369723005414 Walker B motif; other site 369723005415 arginine finger; other site 369723005416 Winged helix-turn helix; Region: HTH_29; pfam13551 369723005417 Homeodomain-like domain; Region: HTH_32; pfam13565 369723005418 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723005419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 369723005420 HTH domain; Region: HTH_11; pfam08279 369723005421 WYL domain; Region: WYL; pfam13280 369723005422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005423 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 369723005424 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 369723005425 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 369723005426 DNA binding residues [nucleotide binding] 369723005427 drug binding residues [chemical binding]; other site 369723005428 dimer interface [polypeptide binding]; other site 369723005429 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005430 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 369723005431 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 369723005432 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005433 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005434 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723005435 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 369723005436 intersubunit interface [polypeptide binding]; other site 369723005437 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005438 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723005439 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005440 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 369723005441 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 369723005442 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 369723005443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723005444 ABC-ATPase subunit interface; other site 369723005445 dimer interface [polypeptide binding]; other site 369723005446 putative PBP binding regions; other site 369723005447 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 369723005448 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005449 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 369723005450 RF-1 domain; Region: RF-1; cl17422 369723005451 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 369723005452 hypothetical protein; Reviewed; Region: PRK09588 369723005453 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 369723005454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 369723005455 Beta-lactamase; Region: Beta-lactamase; pfam00144 369723005456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 369723005457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723005458 Coenzyme A binding pocket [chemical binding]; other site 369723005459 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 369723005460 putative catalytic site [active] 369723005461 metal binding site A [ion binding]; metal-binding site 369723005462 phosphate binding site [ion binding]; other site 369723005463 metal binding site C [ion binding]; metal-binding site 369723005464 metal binding site B [ion binding]; metal-binding site 369723005465 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 369723005466 A new structural DNA glycosylase; Region: AlkD_like; cd06561 369723005467 active site 369723005468 short chain dehydrogenase; Provisional; Region: PRK08303 369723005469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723005470 NAD(P) binding site [chemical binding]; other site 369723005471 active site 369723005472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723005473 dimerization interface [polypeptide binding]; other site 369723005474 putative DNA binding site [nucleotide binding]; other site 369723005475 putative Zn2+ binding site [ion binding]; other site 369723005476 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 369723005477 putative hydrophobic ligand binding site [chemical binding]; other site 369723005478 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 369723005479 active site 369723005480 metal binding site [ion binding]; metal-binding site 369723005481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005482 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 369723005483 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 369723005484 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 369723005485 putative active site [active] 369723005486 catalytic site [active] 369723005487 putative metal binding site [ion binding]; other site 369723005488 oligomer interface [polypeptide binding]; other site 369723005489 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 369723005490 putative metal binding site [ion binding]; other site 369723005491 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 369723005492 metal binding site 2 [ion binding]; metal-binding site 369723005493 putative DNA binding helix; other site 369723005494 metal binding site 1 [ion binding]; metal-binding site 369723005495 dimer interface [polypeptide binding]; other site 369723005496 structural Zn2+ binding site [ion binding]; other site 369723005497 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 369723005498 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 369723005499 dimer interface [polypeptide binding]; other site 369723005500 active site 369723005501 heme binding site [chemical binding]; other site 369723005502 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 369723005503 hypothetical protein; Provisional; Region: PRK08244 369723005504 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005506 Methyltransferase domain; Region: Methyltransf_24; pfam13578 369723005507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723005508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723005509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723005510 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 369723005511 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723005512 Predicted ATPase [General function prediction only]; Region: COG3903 369723005513 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723005514 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723005515 SnoaL-like domain; Region: SnoaL_2; pfam12680 369723005516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723005517 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 369723005518 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 369723005519 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 369723005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723005521 putative substrate translocation pore; other site 369723005522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723005523 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 369723005524 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723005525 DNA-binding site [nucleotide binding]; DNA binding site 369723005526 RNA-binding motif; other site 369723005527 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723005529 putative substrate translocation pore; other site 369723005530 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 369723005531 metal ion-dependent adhesion site (MIDAS); other site 369723005532 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 369723005533 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 369723005534 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 369723005535 FAD binding pocket [chemical binding]; other site 369723005536 FAD binding motif [chemical binding]; other site 369723005537 phosphate binding motif [ion binding]; other site 369723005538 beta-alpha-beta structure motif; other site 369723005539 NAD binding pocket [chemical binding]; other site 369723005540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 369723005541 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 369723005542 catalytic loop [active] 369723005543 iron binding site [ion binding]; other site 369723005544 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 369723005545 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 369723005546 putative di-iron ligands [ion binding]; other site 369723005547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 369723005548 putative ADP-binding pocket [chemical binding]; other site 369723005549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723005550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723005551 active site 369723005552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723005553 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723005554 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723005555 active site 369723005556 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 369723005557 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 369723005558 acyl-activating enzyme (AAE) consensus motif; other site 369723005559 putative AMP binding site [chemical binding]; other site 369723005560 putative active site [active] 369723005561 putative CoA binding site [chemical binding]; other site 369723005562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 369723005563 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 369723005564 active site residue [active] 369723005565 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 369723005566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 369723005567 Rhodanese-like domain; Region: Rhodanese; pfam00581 369723005568 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 369723005569 active site residue [active] 369723005570 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 369723005571 putative homotetramer interface [polypeptide binding]; other site 369723005572 putative homodimer interface [polypeptide binding]; other site 369723005573 putative allosteric switch controlling residues; other site 369723005574 putative metal binding site [ion binding]; other site 369723005575 Protein of unknown function (DUF998); Region: DUF998; pfam06197 369723005576 Predicted membrane protein [Function unknown]; Region: COG3371 369723005577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723005578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723005579 metal binding site [ion binding]; metal-binding site 369723005580 active site 369723005581 I-site; other site 369723005582 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723005583 Helix-turn-helix domain; Region: HTH_31; pfam13560 369723005584 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 369723005585 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 369723005586 serine hydroxymethyltransferase; Provisional; Region: PRK13580 369723005587 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 369723005588 dimer interface [polypeptide binding]; other site 369723005589 active site 369723005590 glycine-pyridoxal phosphate binding site [chemical binding]; other site 369723005591 folate binding site [chemical binding]; other site 369723005592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723005593 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 369723005594 active site 369723005595 metal binding site [ion binding]; metal-binding site 369723005596 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 369723005597 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 369723005598 nucleotide binding site [chemical binding]; other site 369723005599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723005600 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 369723005601 putative DNA binding site [nucleotide binding]; other site 369723005602 putative Zn2+ binding site [ion binding]; other site 369723005603 AsnC family; Region: AsnC_trans_reg; pfam01037 369723005604 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 369723005605 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 369723005606 tetramer interface [polypeptide binding]; other site 369723005607 TPP-binding site [chemical binding]; other site 369723005608 heterodimer interface [polypeptide binding]; other site 369723005609 phosphorylation loop region [posttranslational modification] 369723005610 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 369723005611 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 369723005612 alpha subunit interface [polypeptide binding]; other site 369723005613 TPP binding site [chemical binding]; other site 369723005614 heterodimer interface [polypeptide binding]; other site 369723005615 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723005616 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 369723005617 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 369723005618 E3 interaction surface; other site 369723005619 lipoyl attachment site [posttranslational modification]; other site 369723005620 e3 binding domain; Region: E3_binding; pfam02817 369723005621 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 369723005622 Bacterial Ig-like domain; Region: Big_5; pfam13205 369723005623 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 369723005624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 369723005625 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 369723005626 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 369723005627 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723005628 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 369723005629 intersubunit interface [polypeptide binding]; other site 369723005630 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723005631 FMN binding site [chemical binding]; other site 369723005632 dimer interface [polypeptide binding]; other site 369723005633 Lsr2; Region: Lsr2; pfam11774 369723005634 helicase 45; Provisional; Region: PTZ00424 369723005635 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 369723005636 ATP binding site [chemical binding]; other site 369723005637 Mg++ binding site [ion binding]; other site 369723005638 motif III; other site 369723005639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723005640 nucleotide binding region [chemical binding]; other site 369723005641 ATP-binding site [chemical binding]; other site 369723005642 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 369723005643 RNA binding site [nucleotide binding]; other site 369723005644 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 369723005645 active site 369723005646 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 369723005647 dimer interface [polypeptide binding]; other site 369723005648 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 369723005649 Ligand Binding Site [chemical binding]; other site 369723005650 Molecular Tunnel; other site 369723005651 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 369723005652 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 369723005653 DNA binding residues [nucleotide binding] 369723005654 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 369723005655 LVIVD repeat; Region: LVIVD; pfam08309 369723005656 Domain of unknown function (DUF305); Region: DUF305; pfam03713 369723005657 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723005658 Catalytic domain of Protein Kinases; Region: PKc; cd00180 369723005659 active site 369723005660 ATP binding site [chemical binding]; other site 369723005661 substrate binding site [chemical binding]; other site 369723005662 activation loop (A-loop); other site 369723005663 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 369723005664 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 369723005665 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 369723005666 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 369723005667 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 369723005668 putative active site [active] 369723005669 putative dimer interface [polypeptide binding]; other site 369723005670 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 369723005671 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 369723005672 Predicted membrane protein [Function unknown]; Region: COG2119 369723005673 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 369723005674 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 369723005675 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 369723005676 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 369723005677 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 369723005678 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 369723005679 CoA-transferase family III; Region: CoA_transf_3; pfam02515 369723005680 Integral membrane protein TerC family; Region: TerC; cl10468 369723005681 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 369723005682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723005683 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 369723005684 OsmC-like protein; Region: OsmC; cl00767 369723005685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723005686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723005687 active site 369723005688 phosphorylation site [posttranslational modification] 369723005689 intermolecular recognition site; other site 369723005690 dimerization interface [polypeptide binding]; other site 369723005691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723005692 DNA binding site [nucleotide binding] 369723005693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723005694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723005695 dimer interface [polypeptide binding]; other site 369723005696 phosphorylation site [posttranslational modification] 369723005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723005698 ATP binding site [chemical binding]; other site 369723005699 Mg2+ binding site [ion binding]; other site 369723005700 G-X-G motif; other site 369723005701 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 369723005702 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 369723005703 Ligand binding site; other site 369723005704 Ligand binding site; other site 369723005705 Ligand binding site; other site 369723005706 Putative Catalytic site; other site 369723005707 DXD motif; other site 369723005708 GtrA-like protein; Region: GtrA; pfam04138 369723005709 Sulfatase; Region: Sulfatase; cl17466 369723005710 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 369723005711 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 369723005712 dimer interface [polypeptide binding]; other site 369723005713 active site 369723005714 citrylCoA binding site [chemical binding]; other site 369723005715 NADH binding [chemical binding]; other site 369723005716 cationic pore residues; other site 369723005717 oxalacetate/citrate binding site [chemical binding]; other site 369723005718 coenzyme A binding site [chemical binding]; other site 369723005719 catalytic triad [active] 369723005720 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 369723005721 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 369723005722 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 369723005723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723005724 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 369723005725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723005726 DNA binding residues [nucleotide binding] 369723005727 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 369723005728 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 369723005729 D-pathway; other site 369723005730 Putative ubiquinol binding site [chemical binding]; other site 369723005731 Low-spin heme (heme b) binding site [chemical binding]; other site 369723005732 Putative water exit pathway; other site 369723005733 Binuclear center (heme o3/CuB) [ion binding]; other site 369723005734 K-pathway; other site 369723005735 Putative proton exit pathway; other site 369723005736 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 369723005737 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 369723005738 GAF domain; Region: GAF_2; pfam13185 369723005739 ANTAR domain; Region: ANTAR; pfam03861 369723005740 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 369723005741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723005742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723005743 DNA binding site [nucleotide binding] 369723005744 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 369723005745 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 369723005746 Cupin-like domain; Region: Cupin_8; pfam13621 369723005747 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 369723005748 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 369723005749 Clp amino terminal domain; Region: Clp_N; pfam02861 369723005750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723005751 Walker A motif; other site 369723005752 ATP binding site [chemical binding]; other site 369723005753 Walker B motif; other site 369723005754 arginine finger; other site 369723005755 UvrB/uvrC motif; Region: UVR; pfam02151 369723005756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723005757 Walker A motif; other site 369723005758 ATP binding site [chemical binding]; other site 369723005759 Walker B motif; other site 369723005760 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 369723005761 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 369723005762 hypothetical protein; Provisional; Region: PRK07906 369723005763 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 369723005764 putative metal binding site [ion binding]; other site 369723005765 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723005766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723005767 active site 369723005768 catalytic tetrad [active] 369723005769 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 369723005770 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 369723005771 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 369723005772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723005773 catalytic core [active] 369723005774 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 369723005775 conserved hypothetical protein; Region: TIGR03843 369723005776 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 369723005777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723005778 active site 369723005779 HIGH motif; other site 369723005780 nucleotide binding site [chemical binding]; other site 369723005781 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723005782 active site 369723005783 KMSKS motif; other site 369723005784 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 369723005785 tRNA binding surface [nucleotide binding]; other site 369723005786 anticodon binding site; other site 369723005787 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723005788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723005789 DNA-binding site [nucleotide binding]; DNA binding site 369723005790 UTRA domain; Region: UTRA; pfam07702 369723005791 PAC2 family; Region: PAC2; pfam09754 369723005792 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 369723005793 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 369723005794 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 369723005795 substrate binding pocket [chemical binding]; other site 369723005796 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 369723005797 B12 binding site [chemical binding]; other site 369723005798 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 369723005799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723005800 putative substrate translocation pore; other site 369723005801 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 369723005802 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 369723005803 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723005804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723005805 Walker A/P-loop; other site 369723005806 ATP binding site [chemical binding]; other site 369723005807 Q-loop/lid; other site 369723005808 ABC transporter signature motif; other site 369723005809 Walker B; other site 369723005810 D-loop; other site 369723005811 H-loop/switch region; other site 369723005812 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 369723005813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005814 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723005815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723005816 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 369723005817 DNA binding site [nucleotide binding] 369723005818 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723005819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723005820 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723005821 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 369723005822 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 369723005823 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 369723005824 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 369723005825 FAD binding domain; Region: FAD_binding_3; pfam01494 369723005826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723005827 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005828 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 369723005829 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 369723005830 ParB-like nuclease domain; Region: ParB; smart00470 369723005831 hypothetical protein; Provisional; Region: PRK07236 369723005832 hypothetical protein; Provisional; Region: PRK06834 369723005833 hypothetical protein; Provisional; Region: PRK08244 369723005834 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005835 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723005837 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 369723005838 NAD(P) binding site [chemical binding]; other site 369723005839 active site 369723005840 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 369723005841 NmrA-like family; Region: NmrA; pfam05368 369723005842 NADP binding site [chemical binding]; other site 369723005843 active site 369723005844 regulatory binding site [polypeptide binding]; other site 369723005845 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723005846 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 369723005847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723005848 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723005849 NAD(P) binding site [chemical binding]; other site 369723005850 active site 369723005851 O-methyltransferase; Region: Methyltransf_2; pfam00891 369723005852 hypothetical protein; Provisional; Region: PRK06834 369723005853 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005854 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005855 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 369723005856 putative hydrophobic ligand binding site [chemical binding]; other site 369723005857 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 369723005858 putative hydrophobic ligand binding site [chemical binding]; other site 369723005859 hypothetical protein; Provisional; Region: PRK08244 369723005860 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005861 hypothetical protein; Provisional; Region: PRK06834 369723005862 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723005863 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 369723005864 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 369723005865 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 369723005866 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 369723005867 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 369723005868 putative amidase; Provisional; Region: PRK06169 369723005869 Amidase; Region: Amidase; cl11426 369723005870 adenylosuccinate lyase; Provisional; Region: PRK07380 369723005871 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 369723005872 tetramer interface [polypeptide binding]; other site 369723005873 active site 369723005874 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 369723005875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 369723005876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723005877 Coenzyme A binding pocket [chemical binding]; other site 369723005878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723005879 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723005880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723005881 Walker A/P-loop; other site 369723005882 ATP binding site [chemical binding]; other site 369723005883 Q-loop/lid; other site 369723005884 ABC transporter signature motif; other site 369723005885 Walker B; other site 369723005886 D-loop; other site 369723005887 H-loop/switch region; other site 369723005888 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 369723005889 [2Fe-2S] cluster binding site [ion binding]; other site 369723005890 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 369723005891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005892 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 369723005893 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 369723005894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723005895 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 369723005896 TAP-like protein; Region: Abhydrolase_4; pfam08386 369723005897 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 369723005898 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 369723005899 homodimer interface [polypeptide binding]; other site 369723005900 active site 369723005901 TDP-binding site; other site 369723005902 acceptor substrate-binding pocket; other site 369723005903 O-methyltransferase; Region: Methyltransf_2; pfam00891 369723005904 extended (e) SDRs; Region: SDR_e; cd08946 369723005905 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 369723005906 NAD(P) binding site [chemical binding]; other site 369723005907 active site 369723005908 substrate binding site [chemical binding]; other site 369723005909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723005910 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 369723005911 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 369723005912 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723005913 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 369723005914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 369723005915 putative active site [active] 369723005916 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 369723005917 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 369723005918 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 369723005919 inhibitor-cofactor binding pocket; inhibition site 369723005920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723005921 catalytic residue [active] 369723005922 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 369723005923 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 369723005924 NAD binding site [chemical binding]; other site 369723005925 substrate binding site [chemical binding]; other site 369723005926 homodimer interface [polypeptide binding]; other site 369723005927 active site 369723005928 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 369723005929 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723005930 dimer interface [polypeptide binding]; other site 369723005931 active site 369723005932 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 369723005933 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723005934 active site 369723005935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723005936 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723005937 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723005938 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 369723005939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723005940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723005941 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 369723005942 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 369723005943 substrate binding site; other site 369723005944 tetramer interface; other site 369723005945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723005946 putative substrate translocation pore; other site 369723005947 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 369723005948 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 369723005949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723005950 motif II; other site 369723005951 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 369723005952 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 369723005953 FtsX-like permease family; Region: FtsX; pfam02687 369723005954 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 369723005955 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 369723005956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723005957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 369723005958 Walker A/P-loop; other site 369723005959 ATP binding site [chemical binding]; other site 369723005960 Q-loop/lid; other site 369723005961 ABC transporter signature motif; other site 369723005962 Walker B; other site 369723005963 D-loop; other site 369723005964 H-loop/switch region; other site 369723005965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723005967 active site 369723005968 phosphorylation site [posttranslational modification] 369723005969 intermolecular recognition site; other site 369723005970 dimerization interface [polypeptide binding]; other site 369723005971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723005972 DNA binding residues [nucleotide binding] 369723005973 dimerization interface [polypeptide binding]; other site 369723005974 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 369723005975 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 369723005976 active site 369723005977 putative substrate binding region [chemical binding]; other site 369723005978 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 369723005979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723005980 S-adenosylmethionine binding site [chemical binding]; other site 369723005981 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 369723005982 proteasome ATPase; Region: pup_AAA; TIGR03689 369723005983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723005984 Walker A motif; other site 369723005985 ATP binding site [chemical binding]; other site 369723005986 Walker B motif; other site 369723005987 arginine finger; other site 369723005988 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 369723005989 Pup-like protein; Region: Pup; pfam05639 369723005990 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 369723005991 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 369723005992 active site 369723005993 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 369723005994 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 369723005995 active site 369723005996 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 369723005997 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 369723005998 NAD binding site [chemical binding]; other site 369723005999 substrate binding site [chemical binding]; other site 369723006000 homodimer interface [polypeptide binding]; other site 369723006001 active site 369723006002 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 369723006003 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 369723006004 WYL domain; Region: WYL; pfam13280 369723006005 Predicted transcriptional regulator [Transcription]; Region: COG2378 369723006006 WYL domain; Region: WYL; pfam13280 369723006007 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 369723006008 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 369723006009 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 369723006010 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 369723006011 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 369723006012 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 369723006013 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 369723006014 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 369723006015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723006016 ATP binding site [chemical binding]; other site 369723006017 putative Mg++ binding site [ion binding]; other site 369723006018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723006019 nucleotide binding region [chemical binding]; other site 369723006020 ATP-binding site [chemical binding]; other site 369723006021 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 369723006022 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 369723006023 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 369723006024 active site 369723006025 metal binding site 1 [ion binding]; metal-binding site 369723006026 putative 5' ssDNA interaction site; other site 369723006027 metal binding site 3; metal-binding site 369723006028 metal binding site 2 [ion binding]; metal-binding site 369723006029 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 369723006030 putative DNA binding site [nucleotide binding]; other site 369723006031 putative metal binding site [ion binding]; other site 369723006032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006034 active site 369723006035 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 369723006036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723006037 putative DNA binding site [nucleotide binding]; other site 369723006038 putative Zn2+ binding site [ion binding]; other site 369723006039 AsnC family; Region: AsnC_trans_reg; pfam01037 369723006040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723006041 catalytic core [active] 369723006042 CsbD-like; Region: CsbD; cl17424 369723006043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 369723006044 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 369723006045 active site 369723006046 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 369723006047 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 369723006048 B12 binding site [chemical binding]; other site 369723006049 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723006050 active site 2 [active] 369723006051 MutL protein; Region: MutL; pfam13941 369723006052 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 369723006053 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 369723006054 putative active site [active] 369723006055 catalytic triad [active] 369723006056 putative dimer interface [polypeptide binding]; other site 369723006057 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 369723006058 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 369723006059 Ligand binding site; other site 369723006060 Putative Catalytic site; other site 369723006061 DXD motif; other site 369723006062 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 369723006063 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 369723006064 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 369723006065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723006066 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 369723006067 putative DNA binding site [nucleotide binding]; other site 369723006068 putative Zn2+ binding site [ion binding]; other site 369723006069 AsnC family; Region: AsnC_trans_reg; pfam01037 369723006070 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 369723006071 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 369723006072 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 369723006073 homodimer interface [polypeptide binding]; other site 369723006074 NADP binding site [chemical binding]; other site 369723006075 substrate binding site [chemical binding]; other site 369723006076 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723006077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006078 S-adenosylmethionine binding site [chemical binding]; other site 369723006079 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 369723006080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723006081 Coenzyme A binding pocket [chemical binding]; other site 369723006082 hypothetical protein; Provisional; Region: PRK14059 369723006083 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 369723006084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006085 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 369723006086 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723006087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 369723006088 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 369723006089 Cellulose binding domain; Region: CBM_2; pfam00553 369723006090 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 369723006091 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 369723006092 short chain dehydrogenase; Provisional; Region: PRK08303 369723006093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006094 NAD(P) binding site [chemical binding]; other site 369723006095 active site 369723006096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723006097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006098 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 369723006099 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723006100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006101 putative substrate translocation pore; other site 369723006102 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723006103 Cytochrome P450; Region: p450; cl12078 369723006104 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 369723006105 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 369723006106 B12 binding site [chemical binding]; other site 369723006107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723006108 FeS/SAM binding site; other site 369723006109 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 369723006110 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723006111 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 369723006112 Erythromycin esterase; Region: Erythro_esteras; pfam05139 369723006113 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 369723006114 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006115 DNA binding residues [nucleotide binding] 369723006116 putative dimer interface [polypeptide binding]; other site 369723006117 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 369723006118 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006119 DNA binding residues [nucleotide binding] 369723006120 putative dimer interface [polypeptide binding]; other site 369723006121 Peptidase family M48; Region: Peptidase_M48; cl12018 369723006122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723006123 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723006124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006125 S-adenosylmethionine binding site [chemical binding]; other site 369723006126 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006128 S-adenosylmethionine binding site [chemical binding]; other site 369723006129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723006130 dimerization interface [polypeptide binding]; other site 369723006131 putative DNA binding site [nucleotide binding]; other site 369723006132 putative Zn2+ binding site [ion binding]; other site 369723006133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006134 multidrug resistance protein MdtH; Provisional; Region: PRK11646 369723006135 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 369723006136 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 369723006137 dimer interface [polypeptide binding]; other site 369723006138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723006139 catalytic residue [active] 369723006140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723006141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723006142 non-specific DNA binding site [nucleotide binding]; other site 369723006143 salt bridge; other site 369723006144 sequence-specific DNA binding site [nucleotide binding]; other site 369723006145 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 369723006146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723006147 DNA binding residues [nucleotide binding] 369723006148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 369723006149 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 369723006150 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006151 DNA binding residues [nucleotide binding] 369723006152 drug binding residues [chemical binding]; other site 369723006153 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 369723006154 active site 369723006155 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 369723006156 catalytic residues [active] 369723006157 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 369723006158 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 369723006159 Phosphotransferase enzyme family; Region: APH; pfam01636 369723006160 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 369723006161 substrate binding site [chemical binding]; other site 369723006162 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 369723006163 Protein phosphatase 2C; Region: PP2C; pfam00481 369723006164 active site 369723006165 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 369723006166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723006167 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 369723006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723006169 homodimer interface [polypeptide binding]; other site 369723006170 catalytic residue [active] 369723006171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723006172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723006173 non-specific DNA binding site [nucleotide binding]; other site 369723006174 salt bridge; other site 369723006175 sequence-specific DNA binding site [nucleotide binding]; other site 369723006176 short chain dehydrogenase; Provisional; Region: PRK08263 369723006177 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 369723006178 NADP binding site [chemical binding]; other site 369723006179 active site 369723006180 steroid binding site; other site 369723006181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723006182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006183 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 369723006184 amphipathic channel; other site 369723006185 Asn-Pro-Ala signature motifs; other site 369723006186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723006187 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 369723006188 active site 369723006189 DNA binding site [nucleotide binding] 369723006190 Int/Topo IB signature motif; other site 369723006191 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 369723006192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723006193 Walker A/P-loop; other site 369723006194 ATP binding site [chemical binding]; other site 369723006195 Q-loop/lid; other site 369723006196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723006197 ABC transporter signature motif; other site 369723006198 Walker B; other site 369723006199 D-loop; other site 369723006200 H-loop/switch region; other site 369723006201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723006202 Walker A/P-loop; other site 369723006203 ATP binding site [chemical binding]; other site 369723006204 Q-loop/lid; other site 369723006205 ABC transporter signature motif; other site 369723006206 Walker B; other site 369723006207 D-loop; other site 369723006208 H-loop/switch region; other site 369723006209 short chain dehydrogenase; Provisional; Region: PRK06123 369723006210 classical (c) SDRs; Region: SDR_c; cd05233 369723006211 NAD(P) binding site [chemical binding]; other site 369723006212 active site 369723006213 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 369723006214 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 369723006215 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 369723006216 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 369723006217 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 369723006218 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723006219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 369723006220 putative acyl-acceptor binding pocket; other site 369723006221 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 369723006222 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 369723006223 putative active site [active] 369723006224 catalytic site [active] 369723006225 putative metal binding site [ion binding]; other site 369723006226 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 369723006227 thymidine kinase; Provisional; Region: PRK04296 369723006228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 369723006229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723006230 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 369723006231 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 369723006232 active site 369723006233 metal binding site [ion binding]; metal-binding site 369723006234 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723006235 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 369723006236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723006237 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 369723006238 active site 369723006239 Int/Topo IB signature motif; other site 369723006240 DNA binding site [nucleotide binding] 369723006241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 369723006246 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723006248 Transcriptional regulators [Transcription]; Region: MarR; COG1846 369723006249 MarR family; Region: MarR; pfam01047 369723006250 MarR family; Region: MarR_2; cl17246 369723006251 Predicted flavoprotein [General function prediction only]; Region: COG0431 369723006252 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723006253 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723006254 GYD domain; Region: GYD; pfam08734 369723006255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723006256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006257 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 369723006258 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 369723006259 active site 369723006260 catalytic residues [active] 369723006261 metal binding site [ion binding]; metal-binding site 369723006262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 369723006263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006264 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 369723006265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006266 hypothetical protein; Provisional; Region: PRK01346 369723006267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723006268 Coenzyme A binding pocket [chemical binding]; other site 369723006269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723006270 Cytochrome P450; Region: p450; cl12078 369723006271 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 369723006272 Tautomerase enzyme; Region: Tautomerase; pfam01361 369723006273 active site 1 [active] 369723006274 dimer interface [polypeptide binding]; other site 369723006275 hexamer interface [polypeptide binding]; other site 369723006276 active site 2 [active] 369723006277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006278 NAD(P) binding site [chemical binding]; other site 369723006279 active site 369723006280 short chain dehydrogenase; Provisional; Region: PRK12937 369723006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006282 NAD(P) binding site [chemical binding]; other site 369723006283 active site 369723006284 Helix-turn-helix domain; Region: HTH_31; pfam13560 369723006285 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 369723006286 glycine dehydrogenase; Provisional; Region: PRK05367 369723006287 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723006288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723006289 catalytic residue [active] 369723006290 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 369723006291 tetramer interface [polypeptide binding]; other site 369723006292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723006293 catalytic residue [active] 369723006294 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 369723006295 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 369723006296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006297 DNA binding residues [nucleotide binding] 369723006298 Bifunctional nuclease; Region: DNase-RNase; pfam02577 369723006299 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 369723006300 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006301 DNA binding residues [nucleotide binding] 369723006302 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 369723006303 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 369723006304 phosphopeptide binding site; other site 369723006305 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 369723006306 lipoyl attachment site [posttranslational modification]; other site 369723006307 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 369723006308 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 369723006309 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 369723006310 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 369723006311 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723006312 Ligand Binding Site [chemical binding]; other site 369723006313 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 369723006314 Ligand Binding Site [chemical binding]; other site 369723006315 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 369723006316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723006317 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006319 putative substrate translocation pore; other site 369723006320 PhoD-like phosphatase; Region: PhoD; pfam09423 369723006321 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723006322 putative active site [active] 369723006323 putative metal binding site [ion binding]; other site 369723006324 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723006325 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 369723006326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006327 NAD(P) binding site [chemical binding]; other site 369723006328 active site 369723006329 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 369723006330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 369723006331 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 369723006332 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 369723006333 hypothetical protein; Reviewed; Region: PRK09588 369723006334 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 369723006335 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 369723006336 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 369723006337 Walker A/P-loop; other site 369723006338 ATP binding site [chemical binding]; other site 369723006339 Q-loop/lid; other site 369723006340 ABC transporter signature motif; other site 369723006341 Walker B; other site 369723006342 D-loop; other site 369723006343 H-loop/switch region; other site 369723006344 TOBE domain; Region: TOBE_2; pfam08402 369723006345 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 369723006346 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 369723006347 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723006348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723006349 dimer interface [polypeptide binding]; other site 369723006350 conserved gate region; other site 369723006351 putative PBP binding loops; other site 369723006352 ABC-ATPase subunit interface; other site 369723006353 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 369723006354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723006355 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 369723006356 lycopene cyclase; Region: lycopene_cycl; TIGR01789 369723006357 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723006358 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 369723006359 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 369723006360 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 369723006361 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 369723006362 acyl-activating enzyme (AAE) consensus motif; other site 369723006363 putative AMP binding site [chemical binding]; other site 369723006364 putative active site [active] 369723006365 putative CoA binding site [chemical binding]; other site 369723006366 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 369723006367 Ion channel; Region: Ion_trans_2; pfam07885 369723006368 Transcriptional regulators [Transcription]; Region: MarR; COG1846 369723006369 MarR family; Region: MarR; pfam01047 369723006370 Predicted membrane protein [Function unknown]; Region: COG2323 369723006371 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 369723006372 amidohydrolase; Region: amidohydrolases; TIGR01891 369723006373 metal binding site [ion binding]; metal-binding site 369723006374 putative dimer interface [polypeptide binding]; other site 369723006375 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 369723006376 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 369723006377 tetramer interface [polypeptide binding]; other site 369723006378 active site 369723006379 Mg2+/Mn2+ binding site [ion binding]; other site 369723006380 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 369723006381 DNA binding residues [nucleotide binding] 369723006382 MerR family regulatory protein; Region: MerR; pfam00376 369723006383 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723006384 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 369723006385 homodimer interaction site [polypeptide binding]; other site 369723006386 cofactor binding site; other site 369723006387 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 369723006388 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 369723006389 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723006390 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 369723006391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006392 S-adenosylmethionine binding site [chemical binding]; other site 369723006393 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 369723006394 YcaO-like family; Region: YcaO; pfam02624 369723006395 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 369723006396 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 369723006397 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723006398 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723006399 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723006400 Walker A/P-loop; other site 369723006401 ATP binding site [chemical binding]; other site 369723006402 Q-loop/lid; other site 369723006403 ABC transporter signature motif; other site 369723006404 Walker B; other site 369723006405 D-loop; other site 369723006406 H-loop/switch region; other site 369723006407 SpaB C-terminal domain; Region: SpaB_C; pfam14028 369723006408 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 369723006409 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 369723006410 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723006411 FMN binding site [chemical binding]; other site 369723006412 dimer interface [polypeptide binding]; other site 369723006413 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 369723006414 dimer interface [polypeptide binding]; other site 369723006415 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 369723006416 YcaO-like family; Region: YcaO; pfam02624 369723006417 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 369723006418 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 369723006419 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 369723006420 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 369723006421 DNA binding site [nucleotide binding] 369723006422 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723006423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723006424 Walker A motif; other site 369723006425 ATP binding site [chemical binding]; other site 369723006426 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 369723006427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723006428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723006429 dimerization interface [polypeptide binding]; other site 369723006430 DNA binding residues [nucleotide binding] 369723006431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 369723006432 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 369723006433 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 369723006434 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 369723006435 FAD binding pocket [chemical binding]; other site 369723006436 FAD binding motif [chemical binding]; other site 369723006437 phosphate binding motif [ion binding]; other site 369723006438 NAD binding pocket [chemical binding]; other site 369723006439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723006441 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 369723006442 putative active site [active] 369723006443 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 369723006444 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 369723006445 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 369723006446 Calx-beta domain; Region: Calx-beta; cl02522 369723006447 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 369723006448 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 369723006449 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 369723006450 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723006451 nudix motif; other site 369723006452 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 369723006453 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 369723006454 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723006455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006456 S-adenosylmethionine binding site [chemical binding]; other site 369723006457 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723006458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723006459 non-specific DNA binding site [nucleotide binding]; other site 369723006460 salt bridge; other site 369723006461 sequence-specific DNA binding site [nucleotide binding]; other site 369723006462 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723006463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723006464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723006465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723006466 active site 369723006467 phosphorylation site [posttranslational modification] 369723006468 intermolecular recognition site; other site 369723006469 dimerization interface [polypeptide binding]; other site 369723006470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723006471 DNA binding site [nucleotide binding] 369723006472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723006473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723006474 dimerization interface [polypeptide binding]; other site 369723006475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723006476 dimer interface [polypeptide binding]; other site 369723006477 phosphorylation site [posttranslational modification] 369723006478 Chitin binding domain; Region: Chitin_bind_3; pfam03067 369723006479 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 369723006480 Domain of unknown function (DUF305); Region: DUF305; pfam03713 369723006481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723006482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723006483 active site 369723006484 phosphorylation site [posttranslational modification] 369723006485 intermolecular recognition site; other site 369723006486 dimerization interface [polypeptide binding]; other site 369723006487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723006488 DNA binding residues [nucleotide binding] 369723006489 dimerization interface [polypeptide binding]; other site 369723006490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723006491 Histidine kinase; Region: HisKA_3; pfam07730 369723006492 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 369723006493 CAAX protease self-immunity; Region: Abi; pfam02517 369723006494 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 369723006495 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 369723006496 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 369723006497 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 369723006498 glycerol kinase; Provisional; Region: glpK; PRK00047 369723006499 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 369723006500 N- and C-terminal domain interface [polypeptide binding]; other site 369723006501 active site 369723006502 MgATP binding site [chemical binding]; other site 369723006503 catalytic site [active] 369723006504 metal binding site [ion binding]; metal-binding site 369723006505 putative homotetramer interface [polypeptide binding]; other site 369723006506 glycerol binding site [chemical binding]; other site 369723006507 homodimer interface [polypeptide binding]; other site 369723006508 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 369723006509 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 369723006510 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 369723006511 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 369723006512 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 369723006513 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 369723006514 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 369723006515 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 369723006516 active site 369723006517 pyridoxamine kinase; Validated; Region: PRK05756 369723006518 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 369723006519 dimer interface [polypeptide binding]; other site 369723006520 pyridoxal binding site [chemical binding]; other site 369723006521 ATP binding site [chemical binding]; other site 369723006522 heat shock protein 90; Provisional; Region: PRK05218 369723006523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723006524 ATP binding site [chemical binding]; other site 369723006525 Mg2+ binding site [ion binding]; other site 369723006526 G-X-G motif; other site 369723006527 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 369723006528 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 369723006529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723006530 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 369723006531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723006532 homodimer interface [polypeptide binding]; other site 369723006533 catalytic residue [active] 369723006534 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 369723006535 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 369723006536 active site 369723006537 substrate binding site [chemical binding]; other site 369723006538 FMN binding site [chemical binding]; other site 369723006539 putative catalytic residues [active] 369723006540 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 369723006541 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 369723006542 substrate binding pocket [chemical binding]; other site 369723006543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723006544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723006545 Cytochrome P450; Region: p450; cl12078 369723006546 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 369723006547 active site 369723006548 catalytic triad [active] 369723006549 oxyanion hole [active] 369723006550 acyl-CoA synthetase; Validated; Region: PRK06188 369723006551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006553 acyl-activating enzyme (AAE) consensus motif; other site 369723006554 AMP binding site [chemical binding]; other site 369723006555 active site 369723006556 acyl-activating enzyme (AAE) consensus motif; other site 369723006557 CoA binding site [chemical binding]; other site 369723006558 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723006559 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 369723006560 active site 369723006561 catalytic triad [active] 369723006562 oxyanion hole [active] 369723006563 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 369723006564 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 369723006565 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 369723006566 alpha subunit interface [polypeptide binding]; other site 369723006567 TPP binding site [chemical binding]; other site 369723006568 heterodimer interface [polypeptide binding]; other site 369723006569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723006570 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 369723006571 tetramer interface [polypeptide binding]; other site 369723006572 TPP-binding site [chemical binding]; other site 369723006573 heterodimer interface [polypeptide binding]; other site 369723006574 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 369723006575 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 369723006576 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 369723006577 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 369723006578 dimer interface [polypeptide binding]; other site 369723006579 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 369723006580 active site 369723006581 Fe binding site [ion binding]; other site 369723006582 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 369723006583 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723006584 dimer interface [polypeptide binding]; other site 369723006585 active site 369723006586 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006587 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 369723006588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006589 acyl-activating enzyme (AAE) consensus motif; other site 369723006590 acyl-activating enzyme (AAE) consensus motif; other site 369723006591 AMP binding site [chemical binding]; other site 369723006592 active site 369723006593 CoA binding site [chemical binding]; other site 369723006594 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723006595 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 369723006596 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723006597 active site 369723006598 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 369723006599 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 369723006600 AMP-binding enzyme; Region: AMP-binding; pfam00501 369723006601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723006603 acyl-activating enzyme (AAE) consensus motif; other site 369723006604 acyl-activating enzyme (AAE) consensus motif; other site 369723006605 AMP binding site [chemical binding]; other site 369723006606 active site 369723006607 CoA binding site [chemical binding]; other site 369723006608 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 369723006609 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723006610 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723006611 active site 369723006612 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723006613 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 369723006614 dimer interface [polypeptide binding]; other site 369723006615 active site 369723006616 Cupin domain; Region: Cupin_2; pfam07883 369723006617 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 369723006618 putative hydrophobic ligand binding site [chemical binding]; other site 369723006619 active site 369723006620 catalytic residues_2 [active] 369723006621 catalytic residues_1 [active] 369723006622 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 369723006623 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723006624 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723006625 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 369723006626 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 369723006627 carboxyltransferase (CT) interaction site; other site 369723006628 biotinylation site [posttranslational modification]; other site 369723006629 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 369723006630 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 369723006631 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 369723006632 Bacterial transcriptional activator domain; Region: BTAD; smart01043 369723006633 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 369723006634 hypothetical protein; Provisional; Region: PRK07236 369723006635 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 369723006636 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723006637 Y-family of DNA polymerases; Region: PolY; cl12025 369723006638 AAA ATPase domain; Region: AAA_16; pfam13191 369723006639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 369723006640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723006641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723006642 DNA binding residues [nucleotide binding] 369723006643 dimerization interface [polypeptide binding]; other site 369723006644 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 369723006645 cyclase homology domain; Region: CHD; cd07302 369723006646 nucleotidyl binding site; other site 369723006647 metal binding site [ion binding]; metal-binding site 369723006648 dimer interface [polypeptide binding]; other site 369723006649 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 369723006650 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 369723006651 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 369723006652 putative active site [active] 369723006653 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 369723006654 putative active site [active] 369723006655 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 369723006656 active site 369723006657 SAM binding site [chemical binding]; other site 369723006658 homodimer interface [polypeptide binding]; other site 369723006659 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 369723006660 Precorrin-8X methylmutase; Region: CbiC; pfam02570 369723006661 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 369723006662 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 369723006663 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 369723006664 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 369723006665 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 369723006666 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 369723006667 active site 369723006668 SAM binding site [chemical binding]; other site 369723006669 homodimer interface [polypeptide binding]; other site 369723006670 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 369723006671 putative homodimer interface [polypeptide binding]; other site 369723006672 active site 369723006673 SAM binding site [chemical binding]; other site 369723006674 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 369723006675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 369723006676 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 369723006677 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 369723006678 active site 369723006679 SAM binding site [chemical binding]; other site 369723006680 homodimer interface [polypeptide binding]; other site 369723006681 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 369723006682 active site 369723006683 SAM binding site [chemical binding]; other site 369723006684 homodimer interface [polypeptide binding]; other site 369723006685 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 369723006686 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 369723006687 catalytic triad [active] 369723006688 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 369723006689 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 369723006690 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 369723006691 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 369723006692 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 369723006693 metal ion-dependent adhesion site (MIDAS); other site 369723006694 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 369723006695 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 369723006696 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 369723006697 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 369723006698 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 369723006699 FAD binding domain; Region: FAD_binding_2; pfam00890 369723006700 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 369723006701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 369723006702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723006703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723006704 DNA binding site [nucleotide binding] 369723006705 domain linker motif; other site 369723006706 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 369723006707 ligand binding site [chemical binding]; other site 369723006708 dimerization interface [polypeptide binding]; other site 369723006709 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 369723006710 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 369723006711 trimer interface [polypeptide binding]; other site 369723006712 active site 369723006713 substrate binding site [chemical binding]; other site 369723006714 CoA binding site [chemical binding]; other site 369723006715 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 369723006716 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 369723006717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723006718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723006719 Walker A/P-loop; other site 369723006720 ATP binding site [chemical binding]; other site 369723006721 Q-loop/lid; other site 369723006722 ABC transporter signature motif; other site 369723006723 Walker B; other site 369723006724 D-loop; other site 369723006725 H-loop/switch region; other site 369723006726 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 369723006727 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 369723006728 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 369723006729 active site 369723006730 dimer interface [polypeptide binding]; other site 369723006731 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 369723006732 Ligand Binding Site [chemical binding]; other site 369723006733 Molecular Tunnel; other site 369723006734 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 369723006735 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 369723006736 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 369723006737 metal binding site 2 [ion binding]; metal-binding site 369723006738 putative DNA binding helix; other site 369723006739 metal binding site 1 [ion binding]; metal-binding site 369723006740 dimer interface [polypeptide binding]; other site 369723006741 structural Zn2+ binding site [ion binding]; other site 369723006742 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 369723006743 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723006744 DNA binding residues [nucleotide binding] 369723006745 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 369723006746 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 369723006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 369723006748 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 369723006749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723006750 putative PBP binding loops; other site 369723006751 ABC-ATPase subunit interface; other site 369723006752 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 369723006753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723006754 Walker A/P-loop; other site 369723006755 ATP binding site [chemical binding]; other site 369723006756 Q-loop/lid; other site 369723006757 ABC transporter signature motif; other site 369723006758 Walker B; other site 369723006759 D-loop; other site 369723006760 H-loop/switch region; other site 369723006761 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 369723006762 IucA / IucC family; Region: IucA_IucC; pfam04183 369723006763 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 369723006764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 369723006765 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 369723006766 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 369723006767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723006768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723006769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723006770 catalytic residue [active] 369723006771 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 369723006772 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723006773 intersubunit interface [polypeptide binding]; other site 369723006774 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 369723006775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 369723006776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723006777 ABC-ATPase subunit interface; other site 369723006778 dimer interface [polypeptide binding]; other site 369723006779 putative PBP binding regions; other site 369723006780 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 369723006781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723006782 ABC-ATPase subunit interface; other site 369723006783 dimer interface [polypeptide binding]; other site 369723006784 putative PBP binding regions; other site 369723006785 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 369723006786 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 369723006787 Walker A/P-loop; other site 369723006788 ATP binding site [chemical binding]; other site 369723006789 Q-loop/lid; other site 369723006790 ABC transporter signature motif; other site 369723006791 Walker B; other site 369723006792 D-loop; other site 369723006793 H-loop/switch region; other site 369723006794 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 369723006795 active site 369723006796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 369723006797 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 369723006798 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 369723006799 RibD C-terminal domain; Region: RibD_C; pfam01872 369723006800 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 369723006801 dimerization interface [polypeptide binding]; other site 369723006802 active site 369723006803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723006804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723006805 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 369723006806 active site 369723006807 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723006808 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 369723006809 putative NAD(P) binding site [chemical binding]; other site 369723006810 Sulfatase; Region: Sulfatase; cl17466 369723006811 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 369723006812 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 369723006813 FAD binding pocket [chemical binding]; other site 369723006814 FAD binding motif [chemical binding]; other site 369723006815 phosphate binding motif [ion binding]; other site 369723006816 NAD binding pocket [chemical binding]; other site 369723006817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 369723006818 Sporulation and spore germination; Region: Germane; pfam10646 369723006819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723006820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723006821 dimerization interface [polypeptide binding]; other site 369723006822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723006823 dimer interface [polypeptide binding]; other site 369723006824 phosphorylation site [posttranslational modification] 369723006825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723006826 ATP binding site [chemical binding]; other site 369723006827 Mg2+ binding site [ion binding]; other site 369723006828 G-X-G motif; other site 369723006829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723006830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723006831 active site 369723006832 phosphorylation site [posttranslational modification] 369723006833 intermolecular recognition site; other site 369723006834 dimerization interface [polypeptide binding]; other site 369723006835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723006836 DNA binding site [nucleotide binding] 369723006837 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 369723006838 anti sigma factor interaction site; other site 369723006839 regulatory phosphorylation site [posttranslational modification]; other site 369723006840 BON domain; Region: BON; pfam04972 369723006841 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 369723006842 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723006843 FAD binding domain; Region: FAD_binding_4; pfam01565 369723006844 Flavoprotein; Region: Flavoprotein; pfam02441 369723006845 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 369723006846 Sodium Bile acid symporter family; Region: SBF; cl17470 369723006847 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 369723006848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723006849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723006850 Walker A/P-loop; other site 369723006851 ATP binding site [chemical binding]; other site 369723006852 Q-loop/lid; other site 369723006853 ABC transporter signature motif; other site 369723006854 Walker B; other site 369723006855 D-loop; other site 369723006856 H-loop/switch region; other site 369723006857 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 369723006858 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723006860 homodimer interface [polypeptide binding]; other site 369723006861 catalytic residue [active] 369723006862 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 369723006863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723006864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723006865 DNA binding residues [nucleotide binding] 369723006866 Predicted integral membrane protein [Function unknown]; Region: COG5660 369723006867 Putative zinc-finger; Region: zf-HC2; pfam13490 369723006868 Protein of unknown function (DUF461); Region: DUF461; pfam04314 369723006869 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 369723006870 CopC domain; Region: CopC; pfam04234 369723006871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723006872 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 369723006873 Walker A/P-loop; other site 369723006874 ATP binding site [chemical binding]; other site 369723006875 Q-loop/lid; other site 369723006876 ABC transporter signature motif; other site 369723006877 Walker B; other site 369723006878 D-loop; other site 369723006879 H-loop/switch region; other site 369723006880 Cobalt transport protein; Region: CbiQ; cl00463 369723006881 cobalt transport protein CbiN; Provisional; Region: PRK02898 369723006882 cobalt transport protein CbiM; Validated; Region: PRK08319 369723006883 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 369723006884 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723006885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723006886 S-adenosylmethionine binding site [chemical binding]; other site 369723006887 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 369723006888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723006889 FeS/SAM binding site; other site 369723006890 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723006891 Transcriptional regulator PadR-like family; Region: PadR; cl17335 369723006892 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 369723006893 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 369723006894 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 369723006895 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 369723006896 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 369723006897 NAD binding site [chemical binding]; other site 369723006898 catalytic Zn binding site [ion binding]; other site 369723006899 substrate binding site [chemical binding]; other site 369723006900 structural Zn binding site [ion binding]; other site 369723006901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723006902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006903 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 369723006904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006905 NAD(P) binding site [chemical binding]; other site 369723006906 active site 369723006907 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723006908 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723006909 NAD(P) binding site [chemical binding]; other site 369723006910 catalytic residues [active] 369723006911 enoyl-CoA hydratase; Provisional; Region: PRK06495 369723006912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723006913 substrate binding site [chemical binding]; other site 369723006914 oxyanion hole (OAH) forming residues; other site 369723006915 trimer interface [polypeptide binding]; other site 369723006916 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 369723006917 Coenzyme A transferase; Region: CoA_trans; cl17247 369723006918 Nitronate monooxygenase; Region: NMO; pfam03060 369723006919 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 369723006920 FMN binding site [chemical binding]; other site 369723006921 substrate binding site [chemical binding]; other site 369723006922 putative catalytic residue [active] 369723006923 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 369723006924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723006925 dimer interface [polypeptide binding]; other site 369723006926 active site 369723006927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006928 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 369723006929 FAD binding site [chemical binding]; other site 369723006930 substrate binding site [chemical binding]; other site 369723006931 catalytic base [active] 369723006932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006933 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723006934 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 369723006935 active site 369723006936 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 369723006937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723006938 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 369723006939 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723006940 Cytochrome P450; Region: p450; cl12078 369723006941 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 369723006942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723006943 dimer interface [polypeptide binding]; other site 369723006944 active site 369723006945 short chain dehydrogenase; Provisional; Region: PRK07831 369723006946 classical (c) SDRs; Region: SDR_c; cd05233 369723006947 NAD(P) binding site [chemical binding]; other site 369723006948 active site 369723006949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006950 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 369723006951 active site 369723006952 enoyl-CoA hydratase; Provisional; Region: PRK08290 369723006953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723006954 substrate binding site [chemical binding]; other site 369723006955 oxyanion hole (OAH) forming residues; other site 369723006956 trimer interface [polypeptide binding]; other site 369723006957 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 369723006958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006959 active site 369723006960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006961 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723006962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006964 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 369723006965 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723006966 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 369723006967 active site 369723006968 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 369723006969 lipid-transfer protein; Provisional; Region: PRK07855 369723006970 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 369723006971 active site 369723006972 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723006973 active site 2 [active] 369723006974 active site 1 [active] 369723006975 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723006976 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 369723006977 DUF35 OB-fold domain; Region: DUF35; pfam01796 369723006978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006979 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723006980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723006982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723006983 active site 369723006984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723006985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723006986 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 369723006987 CoenzymeA binding site [chemical binding]; other site 369723006988 subunit interaction site [polypeptide binding]; other site 369723006989 PHB binding site; other site 369723006990 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 369723006991 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 369723006992 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723006993 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 369723006994 putative NAD(P) binding site [chemical binding]; other site 369723006995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723006996 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723006997 NAD(P) binding site [chemical binding]; other site 369723006998 active site 369723006999 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 369723007000 short chain dehydrogenase; Provisional; Region: PRK07856 369723007001 classical (c) SDRs; Region: SDR_c; cd05233 369723007002 NAD(P) binding site [chemical binding]; other site 369723007003 active site 369723007004 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 369723007005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723007006 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 369723007007 short chain dehydrogenase; Provisional; Region: PRK07890 369723007008 classical (c) SDRs; Region: SDR_c; cd05233 369723007009 NAD(P) binding site [chemical binding]; other site 369723007010 active site 369723007011 Nitronate monooxygenase; Region: NMO; pfam03060 369723007012 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 369723007013 FMN binding site [chemical binding]; other site 369723007014 substrate binding site [chemical binding]; other site 369723007015 putative catalytic residue [active] 369723007016 acyl-CoA synthetase; Validated; Region: PRK07798 369723007017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007018 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 369723007019 acyl-activating enzyme (AAE) consensus motif; other site 369723007020 acyl-activating enzyme (AAE) consensus motif; other site 369723007021 putative AMP binding site [chemical binding]; other site 369723007022 putative active site [active] 369723007023 putative CoA binding site [chemical binding]; other site 369723007024 enoyl-CoA hydratase; Provisional; Region: PRK07799 369723007025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723007026 substrate binding site [chemical binding]; other site 369723007027 oxyanion hole (OAH) forming residues; other site 369723007028 trimer interface [polypeptide binding]; other site 369723007029 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 369723007030 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007031 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 369723007032 acyl-activating enzyme (AAE) consensus motif; other site 369723007033 acyl-activating enzyme (AAE) consensus motif; other site 369723007034 putative AMP binding site [chemical binding]; other site 369723007035 putative active site [active] 369723007036 putative CoA binding site [chemical binding]; other site 369723007037 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 369723007038 DUF35 OB-fold domain; Region: DUF35; pfam01796 369723007039 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 369723007040 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 369723007041 DUF35 OB-fold domain; Region: DUF35; pfam01796 369723007042 lipid-transfer protein; Provisional; Region: PRK07937 369723007043 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723007044 active site 369723007045 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 369723007046 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 369723007047 active site 369723007048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007049 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723007050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723007051 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007052 Condensation domain; Region: Condensation; pfam00668 369723007053 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007054 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007056 Methyltransferase domain; Region: Methyltransf_12; pfam08242 369723007057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723007058 S-adenosylmethionine binding site [chemical binding]; other site 369723007059 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 369723007060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723007061 Walker A/P-loop; other site 369723007062 ATP binding site [chemical binding]; other site 369723007063 Q-loop/lid; other site 369723007064 ABC transporter signature motif; other site 369723007065 Walker B; other site 369723007066 D-loop; other site 369723007067 H-loop/switch region; other site 369723007068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723007069 Q-loop/lid; other site 369723007070 ABC transporter signature motif; other site 369723007071 Walker B; other site 369723007072 D-loop; other site 369723007073 H-loop/switch region; other site 369723007074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 369723007075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723007076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 369723007077 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 369723007078 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 369723007079 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007080 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723007081 active site 369723007082 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007083 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007084 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 369723007085 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007086 putative NADP binding site [chemical binding]; other site 369723007087 active site 369723007088 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007089 Condensation domain; Region: Condensation; pfam00668 369723007090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007091 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007092 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 369723007093 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007094 Condensation domain; Region: Condensation; pfam00668 369723007095 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007096 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 369723007097 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723007098 acyl-activating enzyme (AAE) consensus motif; other site 369723007099 AMP binding site [chemical binding]; other site 369723007100 Methyltransferase domain; Region: Methyltransf_18; pfam12847 369723007101 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723007102 hypothetical protein; Provisional; Region: PRK06847 369723007103 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 369723007104 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 369723007105 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 369723007106 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 369723007107 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 369723007108 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007109 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 369723007110 acyl-activating enzyme (AAE) consensus motif; other site 369723007111 acyl-activating enzyme (AAE) consensus motif; other site 369723007112 putative AMP binding site [chemical binding]; other site 369723007113 putative active site [active] 369723007114 putative CoA binding site [chemical binding]; other site 369723007115 CoA binding site [chemical binding]; other site 369723007116 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 369723007117 Protein of unknown function (DUF664); Region: DUF664; pfam04978 369723007118 DinB superfamily; Region: DinB_2; pfam12867 369723007119 HEAT repeats; Region: HEAT_2; pfam13646 369723007120 Rubrerythrin [Energy production and conversion]; Region: COG1592 369723007121 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 369723007122 dinuclear metal binding motif [ion binding]; other site 369723007123 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 369723007124 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 369723007125 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 369723007126 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 369723007127 active site 369723007128 Fe binding site [ion binding]; other site 369723007129 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 369723007130 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 369723007131 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007132 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 369723007133 Flavin binding site [chemical binding]; other site 369723007134 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 369723007135 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 369723007136 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 369723007137 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 369723007138 FAD binding pocket [chemical binding]; other site 369723007139 FAD binding motif [chemical binding]; other site 369723007140 phosphate binding motif [ion binding]; other site 369723007141 beta-alpha-beta structure motif; other site 369723007142 NAD(p) ribose binding residues [chemical binding]; other site 369723007143 NAD binding pocket [chemical binding]; other site 369723007144 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 369723007145 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 369723007146 catalytic loop [active] 369723007147 iron binding site [ion binding]; other site 369723007148 hypothetical protein; Validated; Region: PRK07121 369723007149 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 369723007150 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 369723007151 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 369723007152 enoyl-CoA hydratase; Region: PLN02864 369723007153 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723007154 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 369723007155 dimer interaction site [polypeptide binding]; other site 369723007156 substrate-binding tunnel; other site 369723007157 active site 369723007158 catalytic site [active] 369723007159 substrate binding site [chemical binding]; other site 369723007160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007162 active site 369723007163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007164 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723007165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007166 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 369723007167 hydrophobic ligand binding site; other site 369723007168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723007169 dimerization interface [polypeptide binding]; other site 369723007170 putative DNA binding site [nucleotide binding]; other site 369723007171 putative Zn2+ binding site [ion binding]; other site 369723007172 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 369723007173 putative hydrophobic ligand binding site [chemical binding]; other site 369723007174 RibD C-terminal domain; Region: RibD_C; cl17279 369723007175 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 369723007176 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 369723007177 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 369723007178 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007179 Interdomain contacts; other site 369723007180 Cytokine receptor motif; other site 369723007181 CBD_II domain; Region: CBD_II; smart00637 369723007182 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 369723007183 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 369723007184 active site 369723007185 Ca binding site [ion binding]; other site 369723007186 catalytic site [active] 369723007187 Aamy_C domain; Region: Aamy_C; smart00632 369723007188 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 369723007189 starch-binding site 2 [chemical binding]; other site 369723007190 starch-binding site 1 [chemical binding]; other site 369723007191 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 369723007192 starch-binding site 2 [chemical binding]; other site 369723007193 starch-binding site 1 [chemical binding]; other site 369723007194 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 369723007195 dimer interface [polypeptide binding]; other site 369723007196 ligand binding site [chemical binding]; other site 369723007197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723007198 Helix-turn-helix domain; Region: HTH_18; pfam12833 369723007199 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 369723007200 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 369723007201 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 369723007202 NADP binding site [chemical binding]; other site 369723007203 active site 369723007204 steroid binding site; other site 369723007205 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 369723007206 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723007207 DNA binding residues [nucleotide binding] 369723007208 putative dimer interface [polypeptide binding]; other site 369723007209 Ubiquitin-like proteins; Region: UBQ; cl00155 369723007210 hydrophobic patch; other site 369723007211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723007212 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723007213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723007214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007215 Cytochrome P450; Region: p450; cl12078 369723007216 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 369723007217 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 369723007218 active site 369723007219 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007220 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 369723007221 active site 369723007222 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007223 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007224 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 369723007225 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007226 putative NADP binding site [chemical binding]; other site 369723007227 active site 369723007228 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007229 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 369723007230 Family description; Region: VCBS; pfam13517 369723007231 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 369723007232 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 369723007233 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 369723007234 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 369723007235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007236 NAD(P) binding site [chemical binding]; other site 369723007237 active site 369723007238 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 369723007239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723007240 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 369723007241 TIGR03084 family protein; Region: TIGR03084 369723007242 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723007243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007245 active site 369723007246 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 369723007247 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 369723007248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723007249 Epoxide hydrolase N terminus; Region: EHN; pfam06441 369723007250 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723007251 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 369723007252 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 369723007253 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 369723007254 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 369723007255 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 369723007256 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 369723007257 YCII-related domain; Region: YCII; cl00999 369723007258 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 369723007259 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 369723007260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007261 YCII-related domain; Region: YCII; cl00999 369723007262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007264 active site 369723007265 Condensation domain; Region: Condensation; pfam00668 369723007266 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723007268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 369723007269 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 369723007270 Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245 369723007271 NAD binding site [chemical binding]; other site 369723007272 substrate binding site [chemical binding]; other site 369723007273 catalytic Zn binding site [ion binding]; other site 369723007274 structural Zn binding site [ion binding]; other site 369723007275 tetramer interface [polypeptide binding]; other site 369723007276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007277 Cytochrome P450; Region: p450; cl12078 369723007278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723007279 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723007280 acyl-activating enzyme (AAE) consensus motif; other site 369723007281 AMP binding site [chemical binding]; other site 369723007282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007283 MbtH-like protein; Region: MbtH; cl01279 369723007284 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 369723007285 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 369723007286 dimer interface [polypeptide binding]; other site 369723007287 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 369723007288 active site 369723007289 Fe binding site [ion binding]; other site 369723007290 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 369723007291 Methyltransferase domain; Region: Methyltransf_24; pfam13578 369723007292 Homeodomain-like domain; Region: HTH_32; pfam13565 369723007293 Winged helix-turn helix; Region: HTH_29; pfam13551 369723007294 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723007295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723007296 FAD binding domain; Region: FAD_binding_4; pfam01565 369723007297 Berberine and berberine like; Region: BBE; pfam08031 369723007298 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 369723007299 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723007300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723007301 S-adenosylmethionine binding site [chemical binding]; other site 369723007302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007303 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 369723007304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007305 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 369723007306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 369723007307 Bacterial transcriptional activator domain; Region: BTAD; smart01043 369723007308 Predicted ATPase [General function prediction only]; Region: COG3903 369723007309 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 369723007310 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723007311 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 369723007312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723007313 FeS/SAM binding site; other site 369723007314 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 369723007315 Hemerythrin-like domain; Region: Hr-like; cd12108 369723007316 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 369723007317 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 369723007318 active site 369723007319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 369723007320 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 369723007321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 369723007322 sequence-specific DNA binding site [nucleotide binding]; other site 369723007323 salt bridge; other site 369723007324 DDE superfamily endonuclease; Region: DDE_5; cl17874 369723007325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723007326 dimerization interface [polypeptide binding]; other site 369723007327 putative DNA binding site [nucleotide binding]; other site 369723007328 putative Zn2+ binding site [ion binding]; other site 369723007329 Putative sensor; Region: Sensor; pfam13796 369723007330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723007331 Histidine kinase; Region: HisKA_3; pfam07730 369723007332 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 369723007333 ATP binding site [chemical binding]; other site 369723007334 Mg2+ binding site [ion binding]; other site 369723007335 G-X-G motif; other site 369723007336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723007337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723007338 active site 369723007339 phosphorylation site [posttranslational modification] 369723007340 intermolecular recognition site; other site 369723007341 dimerization interface [polypeptide binding]; other site 369723007342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723007343 DNA binding residues [nucleotide binding] 369723007344 dimerization interface [polypeptide binding]; other site 369723007345 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 369723007346 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 369723007347 FtsX-like permease family; Region: FtsX; pfam02687 369723007348 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 369723007349 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 369723007350 FtsX-like permease family; Region: FtsX; pfam02687 369723007351 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723007352 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 369723007353 Walker A/P-loop; other site 369723007354 ATP binding site [chemical binding]; other site 369723007355 Q-loop/lid; other site 369723007356 ABC transporter signature motif; other site 369723007357 Walker B; other site 369723007358 D-loop; other site 369723007359 H-loop/switch region; other site 369723007360 AAA ATPase domain; Region: AAA_16; pfam13191 369723007361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723007362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723007363 DNA binding residues [nucleotide binding] 369723007364 dimerization interface [polypeptide binding]; other site 369723007365 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 369723007366 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 369723007367 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 369723007368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007369 putative substrate translocation pore; other site 369723007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723007372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723007373 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007374 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007375 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007376 active site 369723007377 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007378 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007379 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007380 putative NADP binding site [chemical binding]; other site 369723007381 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007382 active site 369723007383 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007384 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007385 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007386 active site 369723007387 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007388 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007389 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007390 putative NADP binding site [chemical binding]; other site 369723007391 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007392 active site 369723007393 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007394 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007395 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007396 active site 369723007397 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007398 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007399 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007400 putative NADP binding site [chemical binding]; other site 369723007401 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007402 active site 369723007403 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007404 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007405 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007406 active site 369723007407 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007408 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007409 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007410 putative NADP binding site [chemical binding]; other site 369723007411 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007412 active site 369723007413 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007414 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 369723007415 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007416 Cytochrome P450; Region: p450; cl12078 369723007417 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 369723007418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723007419 FeS/SAM binding site; other site 369723007420 aspartate aminotransferase; Provisional; Region: PRK05764 369723007421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723007422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723007423 homodimer interface [polypeptide binding]; other site 369723007424 catalytic residue [active] 369723007425 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 369723007426 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007427 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 369723007428 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723007429 acyl-activating enzyme (AAE) consensus motif; other site 369723007430 AMP binding site [chemical binding]; other site 369723007431 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 369723007432 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723007433 acyl-activating enzyme (AAE) consensus motif; other site 369723007434 AMP binding site [chemical binding]; other site 369723007435 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 369723007436 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 369723007437 Erythronolide synthase docking; Region: Docking; pfam08990 369723007438 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007439 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007440 active site 369723007441 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007442 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007443 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007444 putative NADP binding site [chemical binding]; other site 369723007445 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007446 active site 369723007447 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007448 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007449 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007450 active site 369723007451 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007452 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007453 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007454 putative NADP binding site [chemical binding]; other site 369723007455 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007456 active site 369723007457 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007458 Thioesterase; Region: PKS_TE; smart00824 369723007459 Erythronolide synthase docking; Region: Docking; pfam08990 369723007460 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007461 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723007462 active site 369723007463 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007464 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007465 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 369723007466 NADP binding site [chemical binding]; other site 369723007467 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007468 active site 369723007469 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007470 Erythronolide synthase docking; Region: Docking; pfam08990 369723007471 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007472 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723007473 active site 369723007474 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007475 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007476 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 369723007477 NADP binding site [chemical binding]; other site 369723007478 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007479 active site 369723007480 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007481 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007482 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723007483 active site 369723007484 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007485 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723007486 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 369723007487 NADP binding site [chemical binding]; other site 369723007488 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007489 active site 369723007490 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007491 Erythronolide synthase docking; Region: Docking; pfam08990 369723007492 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007493 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007494 active site 369723007495 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007496 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007497 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007498 putative NADP binding site [chemical binding]; other site 369723007499 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 369723007500 active site 369723007501 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007502 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 369723007503 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723007504 active site 369723007505 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723007506 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 369723007507 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 369723007508 putative NADP binding site [chemical binding]; other site 369723007509 KR domain; Region: KR; pfam08659 369723007510 active site 369723007511 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723007512 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 369723007513 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007514 Cytochrome P450; Region: p450; cl12078 369723007515 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007516 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 369723007517 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 369723007518 acyl-activating enzyme (AAE) consensus motif; other site 369723007519 acyl-activating enzyme (AAE) consensus motif; other site 369723007520 putative AMP binding site [chemical binding]; other site 369723007521 putative active site [active] 369723007522 putative CoA binding site [chemical binding]; other site 369723007523 hypothetical protein; Provisional; Region: PRK06208 369723007524 intersubunit interface [polypeptide binding]; other site 369723007525 active site 369723007526 Zn2+ binding site [ion binding]; other site 369723007527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723007528 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 369723007529 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723007530 active site 1 [active] 369723007531 active site 2 [active] 369723007532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723007533 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723007534 active site 369723007535 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 369723007536 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723007537 active site 369723007538 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723007539 active site 369723007540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 369723007541 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723007542 dimer interface [polypeptide binding]; other site 369723007543 active site 369723007544 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 369723007545 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 369723007546 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723007547 active site 1 [active] 369723007548 active site 2 [active] 369723007549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007550 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 369723007551 NAD(P) binding site [chemical binding]; other site 369723007552 active site 369723007553 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 369723007554 CoA-transferase family III; Region: CoA_transf_3; pfam02515 369723007555 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 369723007556 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723007557 dimer interface [polypeptide binding]; other site 369723007558 active site 369723007559 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 369723007560 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 369723007561 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 369723007562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007563 acyl-activating enzyme (AAE) consensus motif; other site 369723007564 AMP binding site [chemical binding]; other site 369723007565 active site 369723007566 CoA binding site [chemical binding]; other site 369723007567 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 369723007568 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 369723007569 Phosphopantetheine attachment site; Region: PP-binding; cl09936 369723007570 Condensation domain; Region: Condensation; pfam00668 369723007571 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007572 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007573 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 369723007574 acyl-activating enzyme (AAE) consensus motif; other site 369723007575 AMP binding site [chemical binding]; other site 369723007576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007577 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 369723007578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007580 active site 369723007581 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723007582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723007583 S-adenosylmethionine binding site [chemical binding]; other site 369723007584 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 369723007585 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 369723007586 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 369723007587 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 369723007588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 369723007589 putative dimer interface [polypeptide binding]; other site 369723007590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723007591 ligand binding site [chemical binding]; other site 369723007592 Zn binding site [ion binding]; other site 369723007593 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 369723007594 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 369723007595 active site 369723007596 non-prolyl cis peptide bond; other site 369723007597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007599 active site 369723007600 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007601 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 369723007602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007603 active site 369723007604 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 369723007605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723007606 S-adenosylmethionine binding site [chemical binding]; other site 369723007607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007608 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 369723007609 acyl-activating enzyme (AAE) consensus motif; other site 369723007610 AMP binding site [chemical binding]; other site 369723007611 active site 369723007612 CoA binding site [chemical binding]; other site 369723007613 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 369723007614 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 369723007615 nucleophilic elbow; other site 369723007616 catalytic triad; other site 369723007617 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 369723007618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723007619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007620 NAD(P) binding site [chemical binding]; other site 369723007621 Condensation domain; Region: Condensation; pfam00668 369723007622 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007623 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007624 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 369723007625 acyl-activating enzyme (AAE) consensus motif; other site 369723007626 AMP binding site [chemical binding]; other site 369723007627 Methyltransferase domain; Region: Methyltransf_12; pfam08242 369723007628 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007629 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007630 Phosphopantetheine attachment site; Region: PP-binding; cl09936 369723007631 Condensation domain; Region: Condensation; pfam00668 369723007632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007633 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007634 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 369723007635 acyl-activating enzyme (AAE) consensus motif; other site 369723007636 AMP binding site [chemical binding]; other site 369723007637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007638 Condensation domain; Region: Condensation; pfam00668 369723007639 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007640 Nonribosomal peptide synthase; Region: NRPS; pfam08415 369723007641 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 369723007642 acyl-activating enzyme (AAE) consensus motif; other site 369723007643 AMP binding site [chemical binding]; other site 369723007644 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723007645 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 369723007646 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 369723007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723007649 putative substrate translocation pore; other site 369723007650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 369723007652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723007653 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007654 Cytochrome P450; Region: p450; cl12078 369723007655 Condensation domain; Region: Condensation; pfam00668 369723007656 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723007657 Protein of unknown function (DUF419); Region: DUF419; pfam04237 369723007658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723007659 Cytochrome P450; Region: p450; cl12078 369723007660 O-methyltransferase; Region: Methyltransf_2; pfam00891 369723007661 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 369723007662 dinuclear metal binding motif [ion binding]; other site 369723007663 peptide synthase; Validated; Region: PRK05691 369723007664 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 369723007665 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 369723007666 active site 369723007667 dimer interface [polypeptide binding]; other site 369723007668 non-prolyl cis peptide bond; other site 369723007669 insertion regions; other site 369723007670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723007671 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 369723007672 Phosphopantetheine attachment site; Region: PP-binding; cl09936 369723007673 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723007674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723007675 S-adenosylmethionine binding site [chemical binding]; other site 369723007676 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723007678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723007679 active site 369723007680 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 369723007681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723007682 NAD(P) binding site [chemical binding]; other site 369723007683 active site 369723007684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723007685 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723007686 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 369723007687 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723007688 NAD(P) binding site [chemical binding]; other site 369723007689 catalytic residues [active] 369723007690 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723007691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723007692 Walker A/P-loop; other site 369723007693 ATP binding site [chemical binding]; other site 369723007694 Q-loop/lid; other site 369723007695 ABC transporter signature motif; other site 369723007696 Walker B; other site 369723007697 D-loop; other site 369723007698 H-loop/switch region; other site 369723007699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723007700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723007701 Walker A/P-loop; other site 369723007702 ATP binding site [chemical binding]; other site 369723007703 Q-loop/lid; other site 369723007704 ABC transporter signature motif; other site 369723007705 Walker B; other site 369723007706 D-loop; other site 369723007707 H-loop/switch region; other site 369723007708 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 369723007709 DDE superfamily endonuclease; Region: DDE_4; cl17710 369723007710 Winged helix-turn helix; Region: HTH_29; pfam13551 369723007711 Homeodomain-like domain; Region: HTH_32; pfam13565 369723007712 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723007713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 369723007714 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 369723007715 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 369723007716 P-loop; other site 369723007717 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723007718 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 369723007719 Predicted permease; Region: DUF318; cl17795 369723007720 TIGR03943 family protein; Region: TIGR03943 369723007721 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 369723007722 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 369723007723 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 369723007724 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723007725 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 369723007726 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 369723007727 Methyltransferase domain; Region: Methyltransf_18; pfam12847 369723007728 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 369723007729 metal binding site 2 [ion binding]; metal-binding site 369723007730 putative DNA binding helix; other site 369723007731 metal binding site 1 [ion binding]; metal-binding site 369723007732 dimer interface [polypeptide binding]; other site 369723007733 structural Zn2+ binding site [ion binding]; other site 369723007734 Transposase; Region: DEDD_Tnp_IS110; pfam01548 369723007735 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 369723007736 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 369723007737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 369723007738 metal ion-dependent adhesion site (MIDAS); other site 369723007739 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723007740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723007741 Walker A motif; other site 369723007742 ATP binding site [chemical binding]; other site 369723007743 Walker B motif; other site 369723007744 arginine finger; other site 369723007745 NAD-dependent deacetylase; Provisional; Region: PRK00481 369723007746 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 369723007747 NAD+ binding site [chemical binding]; other site 369723007748 substrate binding site [chemical binding]; other site 369723007749 Zn binding site [ion binding]; other site 369723007750 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 369723007751 cleavage site 369723007752 active site 369723007753 substrate binding sites [chemical binding]; other site 369723007754 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 369723007755 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 369723007756 conserved cys residue [active] 369723007757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723007758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723007759 Cupin domain; Region: Cupin_2; cl17218 369723007760 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 369723007761 Uncharacterized conserved protein [Function unknown]; Region: COG3391 369723007762 NHL repeat; Region: NHL; pfam01436 369723007763 NHL repeat; Region: NHL; pfam01436 369723007764 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 369723007765 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 369723007766 metal ion-dependent adhesion site (MIDAS); other site 369723007767 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723007768 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 369723007769 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 369723007770 Acyltransferase family; Region: Acyl_transf_3; pfam01757 369723007771 HAMP domain; Region: HAMP; pfam00672 369723007772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723007773 dimerization interface [polypeptide binding]; other site 369723007774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723007775 dimer interface [polypeptide binding]; other site 369723007776 phosphorylation site [posttranslational modification] 369723007777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723007778 ATP binding site [chemical binding]; other site 369723007779 Mg2+ binding site [ion binding]; other site 369723007780 G-X-G motif; other site 369723007781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723007782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723007783 active site 369723007784 phosphorylation site [posttranslational modification] 369723007785 intermolecular recognition site; other site 369723007786 dimerization interface [polypeptide binding]; other site 369723007787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723007788 DNA binding site [nucleotide binding] 369723007789 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723007790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723007791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723007792 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 369723007793 RNAase interaction site [polypeptide binding]; other site 369723007794 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 369723007795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723007796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 369723007797 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 369723007798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723007799 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 369723007800 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 369723007801 non-specific DNA binding site [nucleotide binding]; other site 369723007802 salt bridge; other site 369723007803 sequence-specific DNA binding site [nucleotide binding]; other site 369723007804 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 369723007805 DNA binding site [nucleotide binding] 369723007806 Int/Topo IB signature motif; other site 369723007807 active site 369723007808 catalytic residues [active] 369723007809 Recombinase; Region: Recombinase; pfam07508 369723007810 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007811 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007812 Interdomain contacts; other site 369723007813 Cytokine receptor motif; other site 369723007814 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007815 Interdomain contacts; other site 369723007816 Cytokine receptor motif; other site 369723007817 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007818 Interdomain contacts; other site 369723007819 Cytokine receptor motif; other site 369723007820 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 369723007821 Interdomain contacts; other site 369723007822 Cytokine receptor motif; other site 369723007823 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723007824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723007825 Walker A motif; other site 369723007826 ATP binding site [chemical binding]; other site 369723007827 Walker B motif; other site 369723007828 arginine finger; other site 369723007829 Protein of unknown function DUF58; Region: DUF58; pfam01882 369723007830 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 369723007831 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 369723007832 classical (c) SDRs; Region: SDR_c; cd05233 369723007833 NAD(P) binding site [chemical binding]; other site 369723007834 active site 369723007835 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 369723007836 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 369723007837 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 369723007838 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 369723007839 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723007840 PAP2 superfamily; Region: PAP2; pfam01569 369723007841 MMPL family; Region: MMPL; pfam03176 369723007842 MMPL family; Region: MMPL; pfam03176 369723007843 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007845 putative substrate translocation pore; other site 369723007846 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 369723007847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007848 Lsr2; Region: Lsr2; pfam11774 369723007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723007851 putative substrate translocation pore; other site 369723007852 Protein of unknown function (DUF328); Region: DUF328; pfam03883 369723007853 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723007854 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 369723007855 Sulfatase; Region: Sulfatase; pfam00884 369723007856 Sulfatase; Region: Sulfatase; cl17466 369723007857 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 369723007858 Predicted membrane protein [Function unknown]; Region: COG4325 369723007859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723007860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723007861 Coenzyme A binding pocket [chemical binding]; other site 369723007862 Uncharacterized conserved protein [Function unknown]; Region: COG1262 369723007863 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 369723007864 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 369723007865 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 369723007866 heme-binding site [chemical binding]; other site 369723007867 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 369723007868 FAD binding pocket [chemical binding]; other site 369723007869 FAD binding motif [chemical binding]; other site 369723007870 phosphate binding motif [ion binding]; other site 369723007871 beta-alpha-beta structure motif; other site 369723007872 NAD binding pocket [chemical binding]; other site 369723007873 Heme binding pocket [chemical binding]; other site 369723007874 YwiC-like protein; Region: YwiC; pfam14256 369723007875 Predicted transcriptional regulator [Transcription]; Region: COG2345 369723007876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723007877 putative DNA binding site [nucleotide binding]; other site 369723007878 dimerization interface [polypeptide binding]; other site 369723007879 putative Zn2+ binding site [ion binding]; other site 369723007880 acyl-CoA synthetase; Validated; Region: PRK07787 369723007881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723007883 acyl-activating enzyme (AAE) consensus motif; other site 369723007884 acyl-activating enzyme (AAE) consensus motif; other site 369723007885 AMP binding site [chemical binding]; other site 369723007886 active site 369723007887 CoA binding site [chemical binding]; other site 369723007888 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 369723007889 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 369723007890 Ricin-type beta-trefoil; Region: RICIN; smart00458 369723007891 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 369723007892 putative sugar binding sites [chemical binding]; other site 369723007893 Q-X-W motif; other site 369723007894 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723007895 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 369723007896 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723007897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723007898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723007899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723007900 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 369723007901 MarR family; Region: MarR_2; pfam12802 369723007902 AAA domain; Region: AAA_28; pfam13521 369723007903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723007904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723007905 dimerization interface [polypeptide binding]; other site 369723007906 putative DNA binding site [nucleotide binding]; other site 369723007907 putative Zn2+ binding site [ion binding]; other site 369723007908 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 369723007909 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 369723007910 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 369723007911 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 369723007912 AAA domain; Region: AAA_17; pfam13207 369723007913 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 369723007914 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 369723007915 active site 369723007916 catalytic site [active] 369723007917 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 369723007918 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 369723007919 Cellulose binding domain; Region: CBM_2; pfam00553 369723007920 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 369723007921 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 369723007922 beta-galactosidase; Region: BGL; TIGR03356 369723007923 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723007924 nucleotide binding site [chemical binding]; other site 369723007925 chorismate binding enzyme; Region: Chorismate_bind; cl10555 369723007926 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 369723007927 Glutamine amidotransferase class-I; Region: GATase; pfam00117 369723007928 conserved cys residue [active] 369723007929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 369723007930 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 369723007931 Ligand binding site; other site 369723007932 Putative Catalytic site; other site 369723007933 DXD motif; other site 369723007934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007935 putative substrate translocation pore; other site 369723007936 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 369723007937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723007939 putative substrate translocation pore; other site 369723007940 CBD_II domain; Region: CBD_II; smart00637 369723007941 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 369723007942 active site 369723007943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 369723007944 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723007945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 369723007946 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 369723007947 nucleophilic elbow; other site 369723007948 catalytic triad; other site 369723007949 short chain dehydrogenase; Provisional; Region: PRK06197 369723007950 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 369723007951 putative NAD(P) binding site [chemical binding]; other site 369723007952 active site 369723007953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723007954 putative substrate translocation pore; other site 369723007955 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 369723007956 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 369723007957 putative ligand binding site [chemical binding]; other site 369723007958 putative NAD binding site [chemical binding]; other site 369723007959 catalytic site [active] 369723007960 haloalkane dehalogenase; Provisional; Region: PRK00870 369723007961 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 369723007962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723007963 motif II; other site 369723007964 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 369723007965 Amidohydrolase; Region: Amidohydro_2; pfam04909 369723007966 active site 369723007967 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 369723007968 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 369723007969 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 369723007970 active site 369723007971 DNA binding site [nucleotide binding] 369723007972 catalytic site [active] 369723007973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723007974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723007975 dimer interface [polypeptide binding]; other site 369723007976 conserved gate region; other site 369723007977 ABC-ATPase subunit interface; other site 369723007978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723007979 dimer interface [polypeptide binding]; other site 369723007980 conserved gate region; other site 369723007981 putative PBP binding loops; other site 369723007982 ABC-ATPase subunit interface; other site 369723007983 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 369723007984 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 369723007985 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 369723007986 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 369723007987 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 369723007988 putative active site [active] 369723007989 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 369723007990 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 369723007991 hinge; other site 369723007992 active site 369723007993 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 369723007994 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 369723007995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723007996 Acyltransferase family; Region: Acyl_transf_3; pfam01757 369723007997 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 369723007998 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 369723007999 tetrameric interface [polypeptide binding]; other site 369723008000 NAD binding site [chemical binding]; other site 369723008001 catalytic residues [active] 369723008002 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 369723008003 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723008004 inhibitor-cofactor binding pocket; inhibition site 369723008005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723008006 catalytic residue [active] 369723008007 Predicted transcriptional regulators [Transcription]; Region: COG1733 369723008008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723008009 dimerization interface [polypeptide binding]; other site 369723008010 putative DNA binding site [nucleotide binding]; other site 369723008011 putative Zn2+ binding site [ion binding]; other site 369723008012 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 369723008013 homotrimer interaction site [polypeptide binding]; other site 369723008014 putative active site [active] 369723008015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723008016 S-adenosylmethionine binding site [chemical binding]; other site 369723008017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008018 NADH(P)-binding; Region: NAD_binding_10; pfam13460 369723008019 NAD(P) binding site [chemical binding]; other site 369723008020 active site 369723008021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 369723008022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008023 NAD(P) binding site [chemical binding]; other site 369723008024 active site 369723008025 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 369723008026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723008027 DNA binding residues [nucleotide binding] 369723008028 putative dimer interface [polypeptide binding]; other site 369723008029 HEAT repeats; Region: HEAT_2; pfam13646 369723008030 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 369723008031 active site 369723008032 homotetramer interface [polypeptide binding]; other site 369723008033 homodimer interface [polypeptide binding]; other site 369723008034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008035 NADH(P)-binding; Region: NAD_binding_10; pfam13460 369723008036 NAD(P) binding site [chemical binding]; other site 369723008037 active site 369723008038 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 369723008039 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 369723008040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723008041 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 369723008042 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 369723008043 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 369723008044 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 369723008045 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723008046 SnoaL-like domain; Region: SnoaL_3; pfam13474 369723008047 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 369723008048 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 369723008049 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 369723008050 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 369723008051 Transglycosylase; Region: Transgly; pfam00912 369723008052 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 369723008053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 369723008054 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 369723008055 Uncharacterized conserved protein [Function unknown]; Region: COG2128 369723008056 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 369723008057 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 369723008058 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 369723008059 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 369723008060 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 369723008061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723008062 active site 369723008063 motif I; other site 369723008064 motif II; other site 369723008065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723008066 ferrochelatase; Reviewed; Region: hemH; PRK00035 369723008067 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 369723008068 C-terminal domain interface [polypeptide binding]; other site 369723008069 active site 369723008070 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 369723008071 active site 369723008072 N-terminal domain interface [polypeptide binding]; other site 369723008073 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 369723008074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008075 NAD(P) binding site [chemical binding]; other site 369723008076 active site 369723008077 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 369723008078 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 369723008079 NAD(P) binding site [chemical binding]; other site 369723008080 homotetramer interface [polypeptide binding]; other site 369723008081 homodimer interface [polypeptide binding]; other site 369723008082 active site 369723008083 Aerotolerance regulator N-terminal; Region: BatA; cl06567 369723008084 von Willebrand factor type A domain; Region: VWA_2; pfam13519 369723008085 metal ion-dependent adhesion site (MIDAS); other site 369723008086 Protein of unknown function DUF58; Region: DUF58; pfam01882 369723008087 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723008088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723008089 Walker A motif; other site 369723008090 ATP binding site [chemical binding]; other site 369723008091 Walker B motif; other site 369723008092 arginine finger; other site 369723008093 Bacterial PH domain; Region: DUF304; cl01348 369723008094 Predicted membrane protein [Function unknown]; Region: COG3428 369723008095 Bacterial PH domain; Region: DUF304; pfam03703 369723008096 Bacterial PH domain; Region: DUF304; cl01348 369723008097 Bacterial PH domain; Region: DUF304; pfam03703 369723008098 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 369723008099 active site 369723008100 Predicted thioesterase [General function prediction only]; Region: COG5496 369723008101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 369723008102 MarR family; Region: MarR_2; pfam12802 369723008103 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 369723008104 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 369723008105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723008106 putative substrate translocation pore; other site 369723008107 Chitin binding domain; Region: Chitin_bind_3; pfam03067 369723008108 Cellulose binding domain; Region: CBM_2; pfam00553 369723008109 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 369723008110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723008111 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 369723008112 active site 369723008113 catalytic residues [active] 369723008114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 369723008115 TPR motif; other site 369723008116 binding surface 369723008117 CHAT domain; Region: CHAT; pfam12770 369723008118 Predicted flavoprotein [General function prediction only]; Region: COG0431 369723008119 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 369723008120 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 369723008121 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 369723008122 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 369723008123 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 369723008124 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 369723008125 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 369723008126 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 369723008127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723008128 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 369723008129 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 369723008130 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 369723008131 metal binding site [ion binding]; metal-binding site 369723008132 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 369723008133 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 369723008134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723008135 S-adenosylmethionine binding site [chemical binding]; other site 369723008136 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 369723008137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723008138 acyl-activating enzyme (AAE) consensus motif; other site 369723008139 AMP binding site [chemical binding]; other site 369723008140 active site 369723008141 CoA binding site [chemical binding]; other site 369723008142 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723008143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 369723008144 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 369723008145 active site 369723008146 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723008147 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 369723008148 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 369723008149 thioester reductase domain; Region: Thioester-redct; TIGR01746 369723008150 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 369723008151 putative NAD(P) binding site [chemical binding]; other site 369723008152 active site 369723008153 putative substrate binding site [chemical binding]; other site 369723008154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723008155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 369723008156 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 369723008157 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 369723008158 active site 369723008159 dimer interface [polypeptide binding]; other site 369723008160 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 369723008161 Ligand Binding Site [chemical binding]; other site 369723008162 Molecular Tunnel; other site 369723008163 proline aminopeptidase P II; Provisional; Region: PRK10879 369723008164 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 369723008165 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 369723008166 active site 369723008167 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 369723008168 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 369723008169 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 369723008170 Ca binding site [ion binding]; other site 369723008171 active site 369723008172 catalytic site [active] 369723008173 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 369723008174 aconitate hydratase; Validated; Region: PRK09277 369723008175 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 369723008176 substrate binding site [chemical binding]; other site 369723008177 ligand binding site [chemical binding]; other site 369723008178 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 369723008179 substrate binding site [chemical binding]; other site 369723008180 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 369723008181 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 369723008182 ATP binding site [chemical binding]; other site 369723008183 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 369723008184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723008185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723008186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723008187 TIGR04222 domain; Region: near_uncomplex 369723008188 hypothetical protein; Provisional; Region: PRK05409 369723008189 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 369723008190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008191 NAD(P) binding site [chemical binding]; other site 369723008192 active site 369723008193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723008194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723008195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723008196 Walker A/P-loop; other site 369723008197 ATP binding site [chemical binding]; other site 369723008198 Q-loop/lid; other site 369723008199 ABC transporter signature motif; other site 369723008200 Walker B; other site 369723008201 D-loop; other site 369723008202 H-loop/switch region; other site 369723008203 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 369723008204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723008205 substrate binding site [chemical binding]; other site 369723008206 oxyanion hole (OAH) forming residues; other site 369723008207 trimer interface [polypeptide binding]; other site 369723008208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 369723008209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723008210 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723008211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723008212 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 369723008213 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 369723008214 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 369723008215 trimerization site [polypeptide binding]; other site 369723008216 active site 369723008217 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 369723008218 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 369723008219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723008220 catalytic residue [active] 369723008221 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 369723008222 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 369723008223 Walker A/P-loop; other site 369723008224 ATP binding site [chemical binding]; other site 369723008225 Q-loop/lid; other site 369723008226 ABC transporter signature motif; other site 369723008227 Walker B; other site 369723008228 D-loop; other site 369723008229 H-loop/switch region; other site 369723008230 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 369723008231 [2Fe-2S] cluster binding site [ion binding]; other site 369723008232 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 369723008233 FeS assembly protein SufD; Region: sufD; TIGR01981 369723008234 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 369723008235 FeS assembly protein SufB; Region: sufB; TIGR01980 369723008236 Predicted transcriptional regulator [Transcription]; Region: COG2345 369723008237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723008238 putative DNA binding site [nucleotide binding]; other site 369723008239 putative Zn2+ binding site [ion binding]; other site 369723008240 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 369723008241 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 369723008242 UbiA prenyltransferase family; Region: UbiA; pfam01040 369723008243 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 369723008244 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 369723008245 TPP-binding site [chemical binding]; other site 369723008246 dimer interface [polypeptide binding]; other site 369723008247 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 369723008248 PYR/PP interface [polypeptide binding]; other site 369723008249 dimer interface [polypeptide binding]; other site 369723008250 TPP binding site [chemical binding]; other site 369723008251 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723008252 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 369723008253 putative active site [active] 369723008254 transaldolase; Provisional; Region: PRK03903 369723008255 catalytic residue [active] 369723008256 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 369723008257 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 369723008258 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 369723008259 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 369723008260 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 369723008261 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 369723008262 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 369723008263 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 369723008264 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 369723008265 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 369723008266 putative active site [active] 369723008267 Preprotein translocase SecG subunit; Region: SecG; cl09123 369723008268 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 369723008269 triosephosphate isomerase; Provisional; Region: PRK14567 369723008270 substrate binding site [chemical binding]; other site 369723008271 dimer interface [polypeptide binding]; other site 369723008272 catalytic triad [active] 369723008273 Phosphoglycerate kinase; Region: PGK; pfam00162 369723008274 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 369723008275 substrate binding site [chemical binding]; other site 369723008276 hinge regions; other site 369723008277 ADP binding site [chemical binding]; other site 369723008278 catalytic site [active] 369723008279 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 369723008280 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 369723008281 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 369723008282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 369723008283 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 369723008284 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 369723008285 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 369723008286 phosphate binding site [ion binding]; other site 369723008287 putative substrate binding pocket [chemical binding]; other site 369723008288 dimer interface [polypeptide binding]; other site 369723008289 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 369723008290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723008291 sequence-specific DNA binding site [nucleotide binding]; other site 369723008292 salt bridge; other site 369723008293 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 369723008294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723008295 ATP binding site [chemical binding]; other site 369723008296 putative Mg++ binding site [ion binding]; other site 369723008297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723008298 nucleotide binding region [chemical binding]; other site 369723008299 ATP-binding site [chemical binding]; other site 369723008300 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 369723008301 HRDC domain; Region: HRDC; pfam00570 369723008302 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 369723008303 oligomeric interface; other site 369723008304 putative active site [active] 369723008305 homodimer interface [polypeptide binding]; other site 369723008306 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 369723008307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723008308 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 369723008309 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 369723008310 GIY-YIG motif/motif A; other site 369723008311 active site 369723008312 catalytic site [active] 369723008313 putative DNA binding site [nucleotide binding]; other site 369723008314 metal binding site [ion binding]; metal-binding site 369723008315 Phage protein GP46; Region: GP46; cl01814 369723008316 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 369723008317 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 369723008318 Helix-hairpin-helix motif; Region: HHH; pfam00633 369723008319 helix-hairpin-helix signature motif; other site 369723008320 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 369723008321 iron-sulfur cluster [ion binding]; other site 369723008322 [2Fe-2S] cluster binding site [ion binding]; other site 369723008323 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 369723008324 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 369723008325 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 369723008326 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 369723008327 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 369723008328 GTP/Mg2+ binding site [chemical binding]; other site 369723008329 G4 box; other site 369723008330 G5 box; other site 369723008331 G1 box; other site 369723008332 Switch I region; other site 369723008333 G2 box; other site 369723008334 G3 box; other site 369723008335 Switch II region; other site 369723008336 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 369723008337 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723008338 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 369723008339 Short repeats of unknown function; Region: ALF; pfam03752 369723008340 Short repeats of unknown function; Region: ALF; pfam03752 369723008341 Short repeats of unknown function; Region: ALF; pfam03752 369723008342 Short repeats of unknown function; Region: ALF; pfam03752 369723008343 Short repeats of unknown function; Region: ALF; pfam03752 369723008344 Trypsin; Region: Trypsin; pfam00089 369723008345 active site 369723008346 substrate binding sites [chemical binding]; other site 369723008347 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723008348 FAD binding domain; Region: FAD_binding_4; pfam01565 369723008349 Predicted methyltransferase [General function prediction only]; Region: COG3897 369723008350 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723008351 DNA-binding site [nucleotide binding]; DNA binding site 369723008352 RNA-binding motif; other site 369723008353 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 369723008354 active site 369723008355 substrate binding sites [chemical binding]; other site 369723008356 Predicted acyl esterases [General function prediction only]; Region: COG2936 369723008357 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 369723008358 MarR family; Region: MarR_2; pfam12802 369723008359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 369723008360 MMPL family; Region: MMPL; pfam03176 369723008361 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 369723008362 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 369723008363 N-acetyl-D-glucosamine binding site [chemical binding]; other site 369723008364 catalytic residue [active] 369723008365 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 369723008366 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 369723008367 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 369723008368 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 369723008369 G1 box; other site 369723008370 putative GEF interaction site [polypeptide binding]; other site 369723008371 GTP/Mg2+ binding site [chemical binding]; other site 369723008372 Switch I region; other site 369723008373 G2 box; other site 369723008374 G3 box; other site 369723008375 Switch II region; other site 369723008376 G4 box; other site 369723008377 G5 box; other site 369723008378 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 369723008379 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 369723008380 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 369723008381 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 369723008382 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 369723008383 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 369723008384 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 369723008385 excinuclease ABC subunit B; Provisional; Region: PRK05298 369723008386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723008387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723008388 nucleotide binding region [chemical binding]; other site 369723008389 ATP-binding site [chemical binding]; other site 369723008390 Ultra-violet resistance protein B; Region: UvrB; pfam12344 369723008391 UvrB/uvrC motif; Region: UVR; pfam02151 369723008392 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 369723008393 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 369723008394 CoA-binding site [chemical binding]; other site 369723008395 ATP-binding [chemical binding]; other site 369723008396 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 369723008397 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 369723008398 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 369723008399 RNA binding site [nucleotide binding]; other site 369723008400 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 369723008401 RNA binding site [nucleotide binding]; other site 369723008402 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 369723008403 RNA binding site [nucleotide binding]; other site 369723008404 S1 RNA binding domain; Region: S1; pfam00575 369723008405 RNA binding site [nucleotide binding]; other site 369723008406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723008407 S-adenosylmethionine binding site [chemical binding]; other site 369723008408 RibD C-terminal domain; Region: RibD_C; cl17279 369723008409 Helix-turn-helix domain; Region: HTH_18; pfam12833 369723008410 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 369723008411 DNA polymerase I; Provisional; Region: PRK05755 369723008412 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 369723008413 active site 369723008414 metal binding site 1 [ion binding]; metal-binding site 369723008415 putative 5' ssDNA interaction site; other site 369723008416 metal binding site 3; metal-binding site 369723008417 metal binding site 2 [ion binding]; metal-binding site 369723008418 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 369723008419 putative DNA binding site [nucleotide binding]; other site 369723008420 putative metal binding site [ion binding]; other site 369723008421 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 369723008422 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 369723008423 active site 369723008424 DNA binding site [nucleotide binding] 369723008425 catalytic site [active] 369723008426 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 369723008427 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 369723008428 Walker A/P-loop; other site 369723008429 ATP binding site [chemical binding]; other site 369723008430 Q-loop/lid; other site 369723008431 ABC transporter signature motif; other site 369723008432 Walker B; other site 369723008433 D-loop; other site 369723008434 H-loop/switch region; other site 369723008435 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 369723008436 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 369723008437 Walker A/P-loop; other site 369723008438 ATP binding site [chemical binding]; other site 369723008439 Q-loop/lid; other site 369723008440 ABC transporter signature motif; other site 369723008441 Walker B; other site 369723008442 D-loop; other site 369723008443 H-loop/switch region; other site 369723008444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723008445 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 369723008446 TM-ABC transporter signature motif; other site 369723008447 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723008448 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 369723008449 TM-ABC transporter signature motif; other site 369723008450 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 369723008451 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 369723008452 dimerization interface [polypeptide binding]; other site 369723008453 ligand binding site [chemical binding]; other site 369723008454 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 369723008455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723008456 active site 369723008457 phosphorylation site [posttranslational modification] 369723008458 intermolecular recognition site; other site 369723008459 dimerization interface [polypeptide binding]; other site 369723008460 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 369723008461 RNA polymerase factor sigma-70; Validated; Region: PRK08241 369723008462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723008463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723008464 DNA binding residues [nucleotide binding] 369723008465 SnoaL-like domain; Region: SnoaL_2; pfam12680 369723008466 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 369723008467 SnoaL-like domain; Region: SnoaL_3; pfam13474 369723008468 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 369723008469 SnoaL-like domain; Region: SnoaL_3; pfam13474 369723008470 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723008471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723008472 putative DNA binding site [nucleotide binding]; other site 369723008473 putative Zn2+ binding site [ion binding]; other site 369723008474 AsnC family; Region: AsnC_trans_reg; pfam01037 369723008475 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 369723008476 Predicted transcriptional regulator [Transcription]; Region: COG1959 369723008477 Transcriptional regulator; Region: Rrf2; pfam02082 369723008478 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 369723008479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723008480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723008481 DNA binding residues [nucleotide binding] 369723008482 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 369723008483 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 369723008484 active site 369723008485 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 369723008486 catalytic triad [active] 369723008487 dimer interface [polypeptide binding]; other site 369723008488 pyruvate kinase; Provisional; Region: PRK06247 369723008489 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 369723008490 domain interfaces; other site 369723008491 active site 369723008492 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 369723008493 Lipase (class 2); Region: Lipase_2; pfam01674 369723008494 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723008495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723008496 Walker A/P-loop; other site 369723008497 ATP binding site [chemical binding]; other site 369723008498 Q-loop/lid; other site 369723008499 ABC transporter signature motif; other site 369723008500 Walker B; other site 369723008501 D-loop; other site 369723008502 H-loop/switch region; other site 369723008503 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 369723008504 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 369723008505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723008506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723008507 non-specific DNA binding site [nucleotide binding]; other site 369723008508 salt bridge; other site 369723008509 sequence-specific DNA binding site [nucleotide binding]; other site 369723008510 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 369723008511 active site 369723008512 catalytic triad [active] 369723008513 oxyanion hole [active] 369723008514 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 369723008515 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723008516 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 369723008517 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 369723008518 active site 369723008519 dimer interface [polypeptide binding]; other site 369723008520 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 369723008521 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 369723008522 active site 369723008523 FMN binding site [chemical binding]; other site 369723008524 substrate binding site [chemical binding]; other site 369723008525 3Fe-4S cluster binding site [ion binding]; other site 369723008526 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 369723008527 domain interface; other site 369723008528 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 369723008529 hypothetical protein; Provisional; Region: PRK07236 369723008530 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723008531 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 369723008532 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 369723008533 substrate binding site [chemical binding]; other site 369723008534 active site 369723008535 catalytic residues [active] 369723008536 heterodimer interface [polypeptide binding]; other site 369723008537 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 369723008538 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 369723008539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723008540 catalytic residue [active] 369723008541 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 369723008542 active site 369723008543 ribulose/triose binding site [chemical binding]; other site 369723008544 phosphate binding site [ion binding]; other site 369723008545 substrate (anthranilate) binding pocket [chemical binding]; other site 369723008546 product (indole) binding pocket [chemical binding]; other site 369723008547 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 369723008548 anthranilate synthase component I; Provisional; Region: PRK13571 369723008549 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 369723008550 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 369723008551 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 369723008552 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 369723008553 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723008554 Walker A/P-loop; other site 369723008555 ATP binding site [chemical binding]; other site 369723008556 Q-loop/lid; other site 369723008557 ABC transporter signature motif; other site 369723008558 Walker B; other site 369723008559 D-loop; other site 369723008560 H-loop/switch region; other site 369723008561 ABC-2 type transporter; Region: ABC2_membrane; cl17235 369723008562 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723008563 transcriptional regulator BetI; Validated; Region: PRK00767 369723008564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723008565 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 369723008566 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723008567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723008568 Walker A/P-loop; other site 369723008569 ATP binding site [chemical binding]; other site 369723008570 Q-loop/lid; other site 369723008571 ABC transporter signature motif; other site 369723008572 Walker B; other site 369723008573 D-loop; other site 369723008574 H-loop/switch region; other site 369723008575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723008576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723008577 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 369723008578 Walker A/P-loop; other site 369723008579 ATP binding site [chemical binding]; other site 369723008580 Q-loop/lid; other site 369723008581 ABC transporter signature motif; other site 369723008582 Walker B; other site 369723008583 D-loop; other site 369723008584 H-loop/switch region; other site 369723008585 TIGR03085 family protein; Region: TIGR03085 369723008586 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 369723008587 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 369723008588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723008589 DNA-binding site [nucleotide binding]; DNA binding site 369723008590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723008591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723008592 homodimer interface [polypeptide binding]; other site 369723008593 catalytic residue [active] 369723008594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 369723008595 Predicted membrane protein [Function unknown]; Region: COG2364 369723008596 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 369723008597 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 369723008598 substrate binding site [chemical binding]; other site 369723008599 glutamase interaction surface [polypeptide binding]; other site 369723008600 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 369723008601 Prostaglandin dehydrogenases; Region: PGDH; cd05288 369723008602 NAD(P) binding site [chemical binding]; other site 369723008603 substrate binding site [chemical binding]; other site 369723008604 dimer interface [polypeptide binding]; other site 369723008605 Transcriptional regulators [Transcription]; Region: MarR; COG1846 369723008606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723008607 putative DNA binding site [nucleotide binding]; other site 369723008608 putative Zn2+ binding site [ion binding]; other site 369723008609 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 369723008610 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 369723008611 catalytic residues [active] 369723008612 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 369723008613 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 369723008614 conserved cys residue [active] 369723008615 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 369723008616 putative active site pocket [active] 369723008617 4-fold oligomerization interface [polypeptide binding]; other site 369723008618 metal binding residues [ion binding]; metal-binding site 369723008619 3-fold/trimer interface [polypeptide binding]; other site 369723008620 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 369723008621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723008622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723008623 homodimer interface [polypeptide binding]; other site 369723008624 catalytic residue [active] 369723008625 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 369723008626 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 369723008627 NAD binding site [chemical binding]; other site 369723008628 dimerization interface [polypeptide binding]; other site 369723008629 product binding site; other site 369723008630 substrate binding site [chemical binding]; other site 369723008631 zinc binding site [ion binding]; other site 369723008632 catalytic residues [active] 369723008633 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 369723008634 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 369723008635 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 369723008636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 369723008637 active site 369723008638 lipoprotein signal peptidase; Provisional; Region: PRK14764 369723008639 lipoprotein signal peptidase; Provisional; Region: PRK14787 369723008640 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 369723008641 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 369723008642 DivIVA protein; Region: DivIVA; pfam05103 369723008643 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723008644 YGGT family; Region: YGGT; pfam02325 369723008645 Protein of unknown function (DUF552); Region: DUF552; pfam04472 369723008646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 369723008647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 369723008648 catalytic residue [active] 369723008649 cell division protein FtsZ; Validated; Region: PRK09330 369723008650 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 369723008651 nucleotide binding site [chemical binding]; other site 369723008652 SulA interaction site; other site 369723008653 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 369723008654 Cell division protein FtsQ; Region: FtsQ; pfam03799 369723008655 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 369723008656 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 369723008657 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723008658 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 369723008659 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 369723008660 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 369723008661 active site 369723008662 homodimer interface [polypeptide binding]; other site 369723008663 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 369723008664 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 369723008665 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 369723008666 Mg++ binding site [ion binding]; other site 369723008667 putative catalytic motif [active] 369723008668 putative substrate binding site [chemical binding]; other site 369723008669 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 369723008670 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 369723008671 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723008672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 369723008673 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 369723008674 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 369723008675 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723008676 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 369723008677 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723008678 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 369723008679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 369723008680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 369723008681 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 369723008682 MraW methylase family; Region: Methyltransf_5; cl17771 369723008683 cell division protein MraZ; Reviewed; Region: PRK00326 369723008684 MraZ protein; Region: MraZ; pfam02381 369723008685 MraZ protein; Region: MraZ; pfam02381 369723008686 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 369723008687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723008688 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 369723008689 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 369723008690 catalytic triad [active] 369723008691 Uncharacterized conserved protein [Function unknown]; Region: COG0398 369723008692 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 369723008693 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 369723008694 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 369723008695 HIGH motif; other site 369723008696 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 369723008697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723008698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723008699 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723008700 active site 369723008701 KMSKS motif; other site 369723008702 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 369723008703 tRNA binding surface [nucleotide binding]; other site 369723008704 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 369723008705 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 369723008706 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 369723008707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723008708 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 369723008709 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 369723008710 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723008711 MoxR-like ATPases [General function prediction only]; Region: COG0714 369723008712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723008713 Walker A motif; other site 369723008714 ATP binding site [chemical binding]; other site 369723008715 Walker B motif; other site 369723008716 arginine finger; other site 369723008717 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 369723008718 Protein of unknown function DUF58; Region: DUF58; pfam01882 369723008719 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 369723008720 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 369723008721 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 369723008722 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 369723008723 active site 369723008724 DNA polymerase IV; Validated; Region: PRK02406 369723008725 DNA binding site [nucleotide binding] 369723008726 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 369723008727 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 369723008728 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 369723008729 active site 369723008730 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 369723008731 generic binding surface I; other site 369723008732 generic binding surface II; other site 369723008733 DNA Polymerase Y-family; Region: PolY_like; cd03468 369723008734 active site 369723008735 DNA binding site [nucleotide binding] 369723008736 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 369723008737 putative deacylase active site [active] 369723008738 Protein of unknown function (DUF422); Region: DUF422; cl00991 369723008739 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 369723008740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 369723008741 active site 369723008742 phytoene desaturase; Region: crtI_fam; TIGR02734 369723008743 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723008744 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 369723008745 FAD binding site [chemical binding]; other site 369723008746 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 369723008747 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 369723008748 substrate binding pocket [chemical binding]; other site 369723008749 chain length determination region; other site 369723008750 substrate-Mg2+ binding site; other site 369723008751 catalytic residues [active] 369723008752 aspartate-rich region 1; other site 369723008753 active site lid residues [active] 369723008754 aspartate-rich region 2; other site 369723008755 Helix-turn-helix domain; Region: HTH_17; pfam12728 369723008756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723008757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 369723008758 active site 369723008759 ATP binding site [chemical binding]; other site 369723008760 substrate binding site [chemical binding]; other site 369723008761 activation loop (A-loop); other site 369723008762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 369723008763 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723008764 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723008765 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723008766 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 369723008767 AP endonuclease family 2; Region: AP2Ec; smart00518 369723008768 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 369723008769 AP (apurinic/apyrimidinic) site pocket; other site 369723008770 DNA interaction; other site 369723008771 Metal-binding active site; metal-binding site 369723008772 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 369723008773 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 369723008774 tetramer interface [polypeptide binding]; other site 369723008775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723008776 catalytic residue [active] 369723008777 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 369723008778 Cellulose binding domain; Region: CBM_2; pfam00553 369723008779 Glyco_18 domain; Region: Glyco_18; smart00636 369723008780 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 369723008781 active site 369723008782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 369723008783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 369723008784 DNA binding site [nucleotide binding] 369723008785 domain linker motif; other site 369723008786 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 369723008787 dimerization interface [polypeptide binding]; other site 369723008788 ligand binding site [chemical binding]; other site 369723008789 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 369723008790 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723008791 putative substrate binding site [chemical binding]; other site 369723008792 putative ATP binding site [chemical binding]; other site 369723008793 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 369723008794 putative active cleft [active] 369723008795 dimerization interface [polypeptide binding]; other site 369723008796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723008797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723008798 dimer interface [polypeptide binding]; other site 369723008799 conserved gate region; other site 369723008800 putative PBP binding loops; other site 369723008801 ABC-ATPase subunit interface; other site 369723008802 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 369723008803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723008804 ABC-ATPase subunit interface; other site 369723008805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723008806 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 369723008807 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 369723008808 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 369723008809 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 369723008810 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 369723008811 phosphofructokinase; Region: PFK_mixed; TIGR02483 369723008812 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 369723008813 active site 369723008814 ADP/pyrophosphate binding site [chemical binding]; other site 369723008815 dimerization interface [polypeptide binding]; other site 369723008816 allosteric effector site; other site 369723008817 fructose-1,6-bisphosphate binding site; other site 369723008818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 369723008819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 369723008820 ligand binding site [chemical binding]; other site 369723008821 flexible hinge region; other site 369723008822 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 369723008823 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 369723008824 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 369723008825 active site 369723008826 homotetramer interface [polypeptide binding]; other site 369723008827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723008828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 369723008829 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 369723008830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723008831 nucleotide binding site [chemical binding]; other site 369723008832 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 369723008833 putative hydrophobic ligand binding site [chemical binding]; other site 369723008834 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 369723008835 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 369723008836 acyl-activating enzyme (AAE) consensus motif; other site 369723008837 putative AMP binding site [chemical binding]; other site 369723008838 putative active site [active] 369723008839 putative CoA binding site [chemical binding]; other site 369723008840 GAF domain; Region: GAF_3; pfam13492 369723008841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723008842 Histidine kinase; Region: HisKA_3; pfam07730 369723008843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723008844 ATP binding site [chemical binding]; other site 369723008845 Mg2+ binding site [ion binding]; other site 369723008846 G-X-G motif; other site 369723008847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723008848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723008849 active site 369723008850 phosphorylation site [posttranslational modification] 369723008851 intermolecular recognition site; other site 369723008852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723008853 DNA binding residues [nucleotide binding] 369723008854 dimerization interface [polypeptide binding]; other site 369723008855 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 369723008856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723008857 S-adenosylmethionine binding site [chemical binding]; other site 369723008858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723008859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723008860 metal binding site [ion binding]; metal-binding site 369723008861 active site 369723008862 I-site; other site 369723008863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723008864 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723008865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723008866 Peptidase family M48; Region: Peptidase_M48; cl12018 369723008867 YacP-like NYN domain; Region: NYN_YacP; cl01491 369723008868 hypothetical protein; Validated; Region: PRK07883 369723008869 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 369723008870 active site 369723008871 catalytic site [active] 369723008872 substrate binding site [chemical binding]; other site 369723008873 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 369723008874 GIY-YIG motif/motif A; other site 369723008875 active site 369723008876 catalytic site [active] 369723008877 putative DNA binding site [nucleotide binding]; other site 369723008878 metal binding site [ion binding]; metal-binding site 369723008879 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 369723008880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 369723008881 Zn2+ binding site [ion binding]; other site 369723008882 Mg2+ binding site [ion binding]; other site 369723008883 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 369723008884 synthetase active site [active] 369723008885 NTP binding site [chemical binding]; other site 369723008886 metal binding site [ion binding]; metal-binding site 369723008887 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 369723008888 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 369723008889 nudix motif; other site 369723008890 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 369723008891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 369723008892 active site 369723008893 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723008894 AsnC family; Region: AsnC_trans_reg; pfam01037 369723008895 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 369723008896 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 369723008897 intrachain domain interface; other site 369723008898 interchain domain interface [polypeptide binding]; other site 369723008899 heme bL binding site [chemical binding]; other site 369723008900 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 369723008901 heme bH binding site [chemical binding]; other site 369723008902 Qo binding site; other site 369723008903 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 369723008904 iron-sulfur cluster [ion binding]; other site 369723008905 [2Fe-2S] cluster binding site [ion binding]; other site 369723008906 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 369723008907 Cytochrome c; Region: Cytochrom_C; pfam00034 369723008908 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 369723008909 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 369723008910 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 369723008911 Subunit I/III interface [polypeptide binding]; other site 369723008912 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 369723008913 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 369723008914 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 369723008915 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 369723008916 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 369723008917 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 369723008918 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 369723008919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723008920 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 369723008921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723008922 catalytic residue [active] 369723008923 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 369723008924 CPxP motif; other site 369723008925 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 369723008926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723008927 substrate binding site [chemical binding]; other site 369723008928 ATP binding site [chemical binding]; other site 369723008929 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 369723008930 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 369723008931 quinolinate synthetase; Provisional; Region: PRK09375 369723008932 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 369723008933 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 369723008934 hinge; other site 369723008935 active site 369723008936 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 369723008937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 369723008938 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723008939 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723008940 active site 369723008941 catalytic tetrad [active] 369723008942 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 369723008943 Peptidase family M50; Region: Peptidase_M50; pfam02163 369723008944 active site 369723008945 putative substrate binding region [chemical binding]; other site 369723008946 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 369723008947 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 369723008948 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 369723008949 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 369723008950 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 369723008951 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 369723008952 multifunctional aminopeptidase A; Provisional; Region: PRK00913 369723008953 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 369723008954 interface (dimer of trimers) [polypeptide binding]; other site 369723008955 Substrate-binding/catalytic site; other site 369723008956 Zn-binding sites [ion binding]; other site 369723008957 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 369723008958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723008959 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 369723008960 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 369723008961 E3 interaction surface; other site 369723008962 lipoyl attachment site [posttranslational modification]; other site 369723008963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 369723008964 E3 interaction surface; other site 369723008965 lipoyl attachment site [posttranslational modification]; other site 369723008966 e3 binding domain; Region: E3_binding; pfam02817 369723008967 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 369723008968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 369723008969 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 369723008970 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 369723008971 DNA binding residues [nucleotide binding] 369723008972 putative dimer interface [polypeptide binding]; other site 369723008973 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723008974 active site 369723008975 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723008976 catalytic tetrad [active] 369723008977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723008978 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 369723008979 NAD(P) binding site [chemical binding]; other site 369723008980 active site 369723008981 lipoate-protein ligase B; Provisional; Region: PRK14345 369723008982 lipoyl synthase; Provisional; Region: PRK05481 369723008983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723008984 FeS/SAM binding site; other site 369723008985 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 369723008986 RDD family; Region: RDD; pfam06271 369723008987 glutamine synthetase, type I; Region: GlnA; TIGR00653 369723008988 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 369723008989 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 369723008990 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 369723008991 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 369723008992 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 369723008993 metal binding triad; other site 369723008994 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 369723008995 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 369723008996 metal binding triad; other site 369723008997 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 369723008998 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 369723008999 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 369723009000 catalytic triad [active] 369723009001 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 369723009002 dimer interface [polypeptide binding]; other site 369723009003 catalytic triad [active] 369723009004 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 369723009005 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 369723009006 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 369723009007 NAD synthetase; Provisional; Region: PRK13981 369723009008 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 369723009009 multimer interface [polypeptide binding]; other site 369723009010 active site 369723009011 catalytic triad [active] 369723009012 protein interface 1 [polypeptide binding]; other site 369723009013 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 369723009014 homodimer interface [polypeptide binding]; other site 369723009015 NAD binding pocket [chemical binding]; other site 369723009016 ATP binding pocket [chemical binding]; other site 369723009017 Mg binding site [ion binding]; other site 369723009018 active-site loop [active] 369723009019 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 369723009020 oligomerization interface [polypeptide binding]; other site 369723009021 active site 369723009022 metal binding site [ion binding]; metal-binding site 369723009023 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 369723009024 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 369723009025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 369723009026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 369723009027 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 369723009028 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 369723009029 putative dimer interface [polypeptide binding]; other site 369723009030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723009031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723009032 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 369723009033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 369723009034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723009035 S-adenosylmethionine binding site [chemical binding]; other site 369723009036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 369723009037 Transposase; Region: HTH_Tnp_1; cl17663 369723009038 Integrase core domain; Region: rve; pfam00665 369723009039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723009040 active site 369723009041 Int/Topo IB signature motif; other site 369723009042 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 369723009043 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 369723009044 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 369723009045 RNA/DNA hybrid binding site [nucleotide binding]; other site 369723009046 active site 369723009047 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723009048 catalytic core [active] 369723009049 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 369723009050 Putative zinc ribbon domain; Region: DUF164; pfam02591 369723009051 Uncharacterized conserved protein [Function unknown]; Region: COG0327 369723009052 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 369723009053 Flavoprotein; Region: Flavoprotein; pfam02441 369723009054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723009055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723009056 non-specific DNA binding site [nucleotide binding]; other site 369723009057 salt bridge; other site 369723009058 sequence-specific DNA binding site [nucleotide binding]; other site 369723009059 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 369723009060 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 369723009061 Uncharacterized conserved protein [Function unknown]; Region: COG4279 369723009062 SNF2 Helicase protein; Region: DUF3670; pfam12419 369723009063 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 369723009064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723009065 ATP binding site [chemical binding]; other site 369723009066 putative Mg++ binding site [ion binding]; other site 369723009067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723009068 nucleotide binding region [chemical binding]; other site 369723009069 ATP-binding site [chemical binding]; other site 369723009070 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 369723009071 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723009072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723009073 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 369723009074 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 369723009075 NodB motif; other site 369723009076 putative active site [active] 369723009077 putative catalytic site [active] 369723009078 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 369723009079 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 369723009080 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 369723009081 dimer interface [polypeptide binding]; other site 369723009082 catalytic triad [active] 369723009083 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 369723009084 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 369723009085 TPP-binding site [chemical binding]; other site 369723009086 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 369723009087 PYR/PP interface [polypeptide binding]; other site 369723009088 dimer interface [polypeptide binding]; other site 369723009089 TPP binding site [chemical binding]; other site 369723009090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 369723009091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 369723009092 MarR family; Region: MarR_2; pfam12802 369723009093 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 369723009094 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 369723009095 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 369723009096 dimer interface [polypeptide binding]; other site 369723009097 TPP-binding site [chemical binding]; other site 369723009098 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 369723009099 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 369723009100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723009101 active site 369723009102 HIGH motif; other site 369723009103 nucleotide binding site [chemical binding]; other site 369723009104 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 369723009105 active site 369723009106 KMSKS motif; other site 369723009107 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 369723009108 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 369723009109 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 369723009110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 369723009111 E3 interaction surface; other site 369723009112 lipoyl attachment site [posttranslational modification]; other site 369723009113 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 369723009114 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 369723009115 dimer interface [polypeptide binding]; other site 369723009116 active site 369723009117 CoA binding pocket [chemical binding]; other site 369723009118 acyl carrier protein; Provisional; Region: acpP; PRK00982 369723009119 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 369723009120 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 369723009121 dimer interface [polypeptide binding]; other site 369723009122 active site 369723009123 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 369723009124 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 369723009125 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 369723009126 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 369723009127 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 369723009128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723009129 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 369723009130 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 369723009131 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 369723009132 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 369723009133 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 369723009134 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 369723009135 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 369723009136 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 369723009137 anti sigma factor interaction site; other site 369723009138 regulatory phosphorylation site [posttranslational modification]; other site 369723009139 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 369723009140 Thioredoxin; Region: Thioredoxin_4; cl17273 369723009141 AAA ATPase domain; Region: AAA_16; pfam13191 369723009142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723009143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723009144 DNA binding residues [nucleotide binding] 369723009145 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 369723009146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 369723009147 NAD binding site [chemical binding]; other site 369723009148 catalytic Zn binding site [ion binding]; other site 369723009149 structural Zn binding site [ion binding]; other site 369723009150 Uncharacterized conserved protein [Function unknown]; Region: COG3268 369723009151 seryl-tRNA synthetase; Provisional; Region: PRK05431 369723009152 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 369723009153 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723009154 motif 1; other site 369723009155 dimer interface [polypeptide binding]; other site 369723009156 active site 369723009157 motif 2; other site 369723009158 motif 3; other site 369723009159 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 369723009160 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723009161 putative NAD(P) binding site [chemical binding]; other site 369723009162 adhesin; Provisional; Region: PRK09752 369723009163 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 369723009164 Peptidase family M50; Region: Peptidase_M50; pfam02163 369723009165 active site 369723009166 putative substrate binding region [chemical binding]; other site 369723009167 FOG: CBS domain [General function prediction only]; Region: COG0517 369723009168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 369723009169 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723009170 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 369723009171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723009172 non-specific DNA binding site [nucleotide binding]; other site 369723009173 salt bridge; other site 369723009174 sequence-specific DNA binding site [nucleotide binding]; other site 369723009175 Cupin domain; Region: Cupin_2; pfam07883 369723009176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723009177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723009178 active site 369723009179 catalytic tetrad [active] 369723009180 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 369723009181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723009182 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 369723009183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723009184 dimerization interface [polypeptide binding]; other site 369723009185 putative DNA binding site [nucleotide binding]; other site 369723009186 putative Zn2+ binding site [ion binding]; other site 369723009187 amidase; Provisional; Region: PRK07487 369723009188 Amidase; Region: Amidase; cl11426 369723009189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723009190 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 369723009191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723009192 MMPL family; Region: MMPL; pfam03176 369723009193 ABC-2 type transporter; Region: ABC2_membrane; cl17235 369723009194 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723009195 ABC-2 type transporter; Region: ABC2_membrane; cl17235 369723009196 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723009197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723009198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723009199 Walker A/P-loop; other site 369723009200 ATP binding site [chemical binding]; other site 369723009201 Q-loop/lid; other site 369723009202 ABC transporter signature motif; other site 369723009203 Walker B; other site 369723009204 D-loop; other site 369723009205 H-loop/switch region; other site 369723009206 DNA primase; Validated; Region: dnaG; PRK05667 369723009207 CHC2 zinc finger; Region: zf-CHC2; pfam01807 369723009208 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 369723009209 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 369723009210 active site 369723009211 metal binding site [ion binding]; metal-binding site 369723009212 interdomain interaction site; other site 369723009213 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 369723009214 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 369723009215 BCCT family transporter; Region: BCCT; pfam02028 369723009216 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 369723009217 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 369723009218 FAD binding pocket [chemical binding]; other site 369723009219 FAD binding motif [chemical binding]; other site 369723009220 phosphate binding motif [ion binding]; other site 369723009221 NAD binding pocket [chemical binding]; other site 369723009222 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 369723009223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 369723009224 Zn2+ binding site [ion binding]; other site 369723009225 Mg2+ binding site [ion binding]; other site 369723009226 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 369723009227 pyruvate phosphate dikinase; Provisional; Region: PRK09279 369723009228 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 369723009229 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 369723009230 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 369723009231 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 369723009232 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 369723009233 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 369723009234 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 369723009235 active site 369723009236 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 369723009237 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 369723009238 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 369723009239 FMN binding site [chemical binding]; other site 369723009240 active site 369723009241 catalytic residues [active] 369723009242 substrate binding site [chemical binding]; other site 369723009243 glycyl-tRNA synthetase; Provisional; Region: PRK04173 369723009244 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723009245 motif 1; other site 369723009246 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 369723009247 active site 369723009248 motif 2; other site 369723009249 motif 3; other site 369723009250 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 369723009251 anticodon binding site; other site 369723009252 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 369723009253 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 369723009254 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 369723009255 intersubunit interface [polypeptide binding]; other site 369723009256 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 369723009257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723009258 Walker A/P-loop; other site 369723009259 ATP binding site [chemical binding]; other site 369723009260 Q-loop/lid; other site 369723009261 ABC transporter signature motif; other site 369723009262 Walker B; other site 369723009263 D-loop; other site 369723009264 H-loop/switch region; other site 369723009265 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 369723009266 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723009267 ABC-ATPase subunit interface; other site 369723009268 dimer interface [polypeptide binding]; other site 369723009269 putative PBP binding regions; other site 369723009270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723009271 dimerization interface [polypeptide binding]; other site 369723009272 putative DNA binding site [nucleotide binding]; other site 369723009273 putative Zn2+ binding site [ion binding]; other site 369723009274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723009275 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723009276 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 369723009277 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723009278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723009279 Walker A/P-loop; other site 369723009280 ATP binding site [chemical binding]; other site 369723009281 Q-loop/lid; other site 369723009282 ABC transporter signature motif; other site 369723009283 Walker B; other site 369723009284 D-loop; other site 369723009285 H-loop/switch region; other site 369723009286 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 369723009287 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723009288 Walker A/P-loop; other site 369723009289 ATP binding site [chemical binding]; other site 369723009290 Q-loop/lid; other site 369723009291 ABC transporter signature motif; other site 369723009292 Walker B; other site 369723009293 D-loop; other site 369723009294 H-loop/switch region; other site 369723009295 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 369723009296 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 369723009297 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 369723009298 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 369723009299 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 369723009300 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 369723009301 catalytic residue [active] 369723009302 putative FPP diphosphate binding site; other site 369723009303 putative FPP binding hydrophobic cleft; other site 369723009304 dimer interface [polypeptide binding]; other site 369723009305 putative IPP diphosphate binding site; other site 369723009306 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 369723009307 Recombination protein O N terminal; Region: RecO_N; pfam11967 369723009308 Recombination protein O C terminal; Region: RecO_C; pfam02565 369723009309 Acyltransferase family; Region: Acyl_transf_3; pfam01757 369723009310 OpgC protein; Region: OpgC_C; cl17858 369723009311 GTPase Era; Reviewed; Region: era; PRK00089 369723009312 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 369723009313 G1 box; other site 369723009314 GTP/Mg2+ binding site [chemical binding]; other site 369723009315 Switch I region; other site 369723009316 G2 box; other site 369723009317 Switch II region; other site 369723009318 G3 box; other site 369723009319 G4 box; other site 369723009320 G5 box; other site 369723009321 KH domain; Region: KH_2; pfam07650 369723009322 Domain of unknown function DUF21; Region: DUF21; pfam01595 369723009323 FOG: CBS domain [General function prediction only]; Region: COG0517 369723009324 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 369723009325 Transporter associated domain; Region: CorC_HlyC; smart01091 369723009326 metal-binding heat shock protein; Provisional; Region: PRK00016 369723009327 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 369723009328 PhoH-like protein; Region: PhoH; pfam02562 369723009329 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 369723009330 RNA methyltransferase, RsmE family; Region: TIGR00046 369723009331 chaperone protein DnaJ; Provisional; Region: PRK14278 369723009332 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 369723009333 HSP70 interaction site [polypeptide binding]; other site 369723009334 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 369723009335 Zn binding sites [ion binding]; other site 369723009336 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 369723009337 dimer interface [polypeptide binding]; other site 369723009338 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 369723009339 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 369723009340 Tic20-like protein; Region: Tic20; pfam09685 369723009341 coproporphyrinogen III oxidase; Validated; Region: PRK05628 369723009342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723009343 FeS/SAM binding site; other site 369723009344 enoyl-CoA hydratase; Provisional; Region: PRK07827 369723009345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723009346 substrate binding site [chemical binding]; other site 369723009347 oxyanion hole (OAH) forming residues; other site 369723009348 trimer interface [polypeptide binding]; other site 369723009349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 369723009350 GTP-binding protein LepA; Provisional; Region: PRK05433 369723009351 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 369723009352 G1 box; other site 369723009353 putative GEF interaction site [polypeptide binding]; other site 369723009354 GTP/Mg2+ binding site [chemical binding]; other site 369723009355 Switch I region; other site 369723009356 G2 box; other site 369723009357 G3 box; other site 369723009358 Switch II region; other site 369723009359 G4 box; other site 369723009360 G5 box; other site 369723009361 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 369723009362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 369723009363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 369723009364 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 369723009365 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 369723009366 Phosphotransferase enzyme family; Region: APH; pfam01636 369723009367 active site 369723009368 ATP binding site [chemical binding]; other site 369723009369 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 369723009370 substrate binding site [chemical binding]; other site 369723009371 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 369723009372 hypothetical protein; Reviewed; Region: PRK07914 369723009373 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 369723009374 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 369723009375 Competence protein; Region: Competence; pfam03772 369723009376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 369723009377 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 369723009378 Helix-hairpin-helix motif; Region: HHH; pfam00633 369723009379 EDD domain protein, DegV family; Region: DegV; TIGR00762 369723009380 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 369723009381 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723009382 Oligomerisation domain; Region: Oligomerisation; pfam02410 369723009383 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 369723009384 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 369723009385 active site 369723009386 (T/H)XGH motif; other site 369723009387 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 369723009388 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 369723009389 Zn binding site [ion binding]; other site 369723009390 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723009391 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 369723009392 GTPase CgtA; Reviewed; Region: obgE; PRK12296 369723009393 GTP1/OBG; Region: GTP1_OBG; pfam01018 369723009394 Obg GTPase; Region: Obg; cd01898 369723009395 G1 box; other site 369723009396 GTP/Mg2+ binding site [chemical binding]; other site 369723009397 Switch I region; other site 369723009398 G2 box; other site 369723009399 G3 box; other site 369723009400 Switch II region; other site 369723009401 G4 box; other site 369723009402 G5 box; other site 369723009403 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 369723009404 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 369723009405 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 369723009406 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 369723009407 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 369723009408 homodimer interface [polypeptide binding]; other site 369723009409 oligonucleotide binding site [chemical binding]; other site 369723009410 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 369723009411 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 369723009412 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 369723009413 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 369723009414 B12 binding site [chemical binding]; other site 369723009415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723009416 FeS/SAM binding site; other site 369723009417 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723009418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 369723009419 putative acyl-acceptor binding pocket; other site 369723009420 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 369723009421 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 369723009422 HIGH motif; other site 369723009423 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 369723009424 active site 369723009425 KMSKS motif; other site 369723009426 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 369723009427 tRNA binding surface [nucleotide binding]; other site 369723009428 anticodon binding site; other site 369723009429 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 369723009430 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 369723009431 putative active site [active] 369723009432 putative metal binding site [ion binding]; other site 369723009433 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 369723009434 active site 369723009435 multimer interface [polypeptide binding]; other site 369723009436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723009437 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723009438 active site 369723009439 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 369723009440 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 369723009441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 369723009442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 369723009443 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 369723009444 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 369723009445 HIGH motif; other site 369723009446 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 369723009447 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 369723009448 active site 369723009449 KMSKS motif; other site 369723009450 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 369723009451 tRNA binding surface [nucleotide binding]; other site 369723009452 anticodon binding site; other site 369723009453 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 369723009454 nitrilase; Region: PLN02798 369723009455 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 369723009456 putative active site [active] 369723009457 catalytic triad [active] 369723009458 dimer interface [polypeptide binding]; other site 369723009459 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 369723009460 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 369723009461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723009462 Walker A motif; other site 369723009463 ATP binding site [chemical binding]; other site 369723009464 Walker B motif; other site 369723009465 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 369723009466 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 369723009467 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 369723009468 oligomer interface [polypeptide binding]; other site 369723009469 active site residues [active] 369723009470 Clp protease; Region: CLP_protease; pfam00574 369723009471 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 369723009472 oligomer interface [polypeptide binding]; other site 369723009473 active site residues [active] 369723009474 trigger factor; Provisional; Region: tig; PRK01490 369723009475 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 369723009476 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 369723009477 Short repeats of unknown function; Region: ALF; pfam03752 369723009478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 369723009479 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 369723009480 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 369723009481 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 369723009482 DNA binding residues [nucleotide binding] 369723009483 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723009484 drug binding residues [chemical binding]; other site 369723009485 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 369723009486 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723009487 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 369723009488 putative NAD(P) binding site [chemical binding]; other site 369723009489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723009490 dimerization interface [polypeptide binding]; other site 369723009491 putative DNA binding site [nucleotide binding]; other site 369723009492 putative Zn2+ binding site [ion binding]; other site 369723009493 hypothetical protein; Provisional; Region: PRK01346 369723009494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723009495 Coenzyme A binding pocket [chemical binding]; other site 369723009496 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 369723009497 Uncharacterized conserved protein [Function unknown]; Region: COG4198 369723009498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 369723009499 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 369723009500 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 369723009501 Zn binding site [ion binding]; other site 369723009502 Repair protein; Region: Repair_PSII; pfam04536 369723009503 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 369723009504 Amidase; Region: Amidase; cl11426 369723009505 Amidohydrolase; Region: Amidohydro_2; pfam04909 369723009506 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 369723009507 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 369723009508 homotrimer interaction site [polypeptide binding]; other site 369723009509 putative active site [active] 369723009510 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 369723009511 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 369723009512 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 369723009513 active site 369723009514 catalytic residues [active] 369723009515 metal binding site [ion binding]; metal-binding site 369723009516 DmpG-like communication domain; Region: DmpG_comm; pfam07836 369723009517 acetaldehyde dehydrogenase; Validated; Region: PRK08300 369723009518 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 369723009519 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 369723009520 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 369723009521 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 369723009522 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 369723009523 NAD binding site [chemical binding]; other site 369723009524 catalytic residues [active] 369723009525 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723009526 FAD binding domain; Region: FAD_binding_3; pfam01494 369723009527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 369723009528 kynureninase; Region: kynureninase; TIGR01814 369723009529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723009530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723009531 catalytic residue [active] 369723009532 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 369723009533 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 369723009534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723009535 putative DNA binding site [nucleotide binding]; other site 369723009536 putative Zn2+ binding site [ion binding]; other site 369723009537 AsnC family; Region: AsnC_trans_reg; pfam01037 369723009538 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 369723009539 active site 369723009540 putative catalytic site [active] 369723009541 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 369723009542 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 369723009543 active site 369723009544 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 369723009545 Mechanosensitive ion channel; Region: MS_channel; pfam00924 369723009546 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723009547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723009548 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 369723009549 apolar tunnel; other site 369723009550 heme binding site [chemical binding]; other site 369723009551 dimerization interface [polypeptide binding]; other site 369723009552 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 369723009553 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 369723009554 active site 369723009555 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 369723009556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723009557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723009558 ABC transporter; Region: ABC_tran_2; pfam12848 369723009559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723009560 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 369723009561 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 369723009562 active site 369723009563 homotetramer interface [polypeptide binding]; other site 369723009564 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 369723009565 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 369723009566 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 369723009567 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 369723009568 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 369723009569 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 369723009570 active site 369723009571 SAM binding site [chemical binding]; other site 369723009572 homodimer interface [polypeptide binding]; other site 369723009573 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 369723009574 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 369723009575 putative dimer interface [polypeptide binding]; other site 369723009576 active site pocket [active] 369723009577 putative cataytic base [active] 369723009578 hypothetical protein; Provisional; Region: PRK07908 369723009579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723009580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723009581 homodimer interface [polypeptide binding]; other site 369723009582 catalytic residue [active] 369723009583 Transglycosylase; Region: Transgly; pfam00912 369723009584 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 369723009585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 369723009586 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 369723009587 hypothetical protein; Provisional; Region: PRK07907 369723009588 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 369723009589 active site 369723009590 metal binding site [ion binding]; metal-binding site 369723009591 dimer interface [polypeptide binding]; other site 369723009592 hypothetical protein; Provisional; Region: PRK06547 369723009593 Rhodanese Homology Domain; Region: RHOD; smart00450 369723009594 active site residue [active] 369723009595 cobyric acid synthase; Provisional; Region: PRK00784 369723009596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723009597 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 369723009598 catalytic triad [active] 369723009599 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 369723009600 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 369723009601 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 369723009602 dimer interface [polypeptide binding]; other site 369723009603 ssDNA binding site [nucleotide binding]; other site 369723009604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 369723009605 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 369723009606 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723009607 YHYH protein; Region: YHYH; pfam14240 369723009608 RibD C-terminal domain; Region: RibD_C; cl17279 369723009609 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 369723009610 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 369723009611 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723009612 putative acyl-acceptor binding pocket; other site 369723009613 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 369723009614 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 369723009615 SCP-2 sterol transfer family; Region: SCP2; pfam02036 369723009616 FOG: CBS domain [General function prediction only]; Region: COG0517 369723009617 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 369723009618 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 369723009619 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 369723009620 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 369723009621 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723009622 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 369723009623 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 369723009624 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723009625 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 369723009626 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 369723009627 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 369723009628 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 369723009629 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 369723009630 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 369723009631 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 369723009632 NlpC/P60 family; Region: NLPC_P60; pfam00877 369723009633 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 369723009634 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 369723009635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723009636 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 369723009637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723009638 DNA binding residues [nucleotide binding] 369723009639 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 369723009640 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 369723009641 active site 369723009642 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 369723009643 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 369723009644 active site 369723009645 metal binding site [ion binding]; metal-binding site 369723009646 TspO/MBR family; Region: TspO_MBR; pfam03073 369723009647 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 369723009648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723009649 dimer interface [polypeptide binding]; other site 369723009650 conserved gate region; other site 369723009651 putative PBP binding loops; other site 369723009652 ABC-ATPase subunit interface; other site 369723009653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 369723009654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723009655 dimer interface [polypeptide binding]; other site 369723009656 conserved gate region; other site 369723009657 putative PBP binding loops; other site 369723009658 ABC-ATPase subunit interface; other site 369723009659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723009660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723009661 putative substrate translocation pore; other site 369723009662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723009663 D-xylulose kinase; Region: XylB; TIGR01312 369723009664 nucleotide binding site [chemical binding]; other site 369723009665 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 369723009666 xylose isomerase; Provisional; Region: PRK12677 369723009667 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 369723009668 Bacterial sugar transferase; Region: Bac_transf; pfam02397 369723009669 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 369723009670 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 369723009671 metal ion-dependent adhesion site (MIDAS); other site 369723009672 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 369723009673 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 369723009674 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 369723009675 G1 box; other site 369723009676 GTP/Mg2+ binding site [chemical binding]; other site 369723009677 G2 box; other site 369723009678 Switch I region; other site 369723009679 G3 box; other site 369723009680 Switch II region; other site 369723009681 G4 box; other site 369723009682 G5 box; other site 369723009683 Protein of unknown function (DUF742); Region: DUF742; pfam05331 369723009684 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 369723009685 Nitrate and nitrite sensing; Region: NIT; pfam08376 369723009686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723009687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723009688 ATP binding site [chemical binding]; other site 369723009689 Mg2+ binding site [ion binding]; other site 369723009690 G-X-G motif; other site 369723009691 Cellulose binding domain; Region: CBM_2; pfam00553 369723009692 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 369723009693 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 369723009694 active site 369723009695 putative catalytic site [active] 369723009696 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 369723009697 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 369723009698 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 369723009699 active site 369723009700 Mn binding site [ion binding]; other site 369723009701 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 369723009702 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 369723009703 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 369723009704 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 369723009705 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 369723009706 Walker A; other site 369723009707 putative acyltransferase; Provisional; Region: PRK05790 369723009708 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723009709 dimer interface [polypeptide binding]; other site 369723009710 active site 369723009711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723009712 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 369723009713 dimer interface [polypeptide binding]; other site 369723009714 substrate binding site [chemical binding]; other site 369723009715 metal binding site [ion binding]; metal-binding site 369723009716 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723009717 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 369723009718 NAD(P) binding site [chemical binding]; other site 369723009719 DivIVA protein; Region: DivIVA; pfam05103 369723009720 DivIVA domain; Region: DivI1A_domain; TIGR03544 369723009721 V-type ATP synthase subunit E; Provisional; Region: PRK01558 369723009722 DivIVA protein; Region: DivIVA; pfam05103 369723009723 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 369723009724 Domain of unknown function DUF20; Region: UPF0118; pfam01594 369723009725 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 369723009726 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 369723009727 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723009728 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 369723009729 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 369723009730 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723009731 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 369723009732 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 369723009733 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 369723009734 NAD(P) binding site [chemical binding]; other site 369723009735 catalytic residues [active] 369723009736 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 369723009737 hypothetical protein; Provisional; Region: PRK03298 369723009738 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 369723009739 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 369723009740 B12 binding site [chemical binding]; other site 369723009741 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723009742 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723009743 Walker A/P-loop; other site 369723009744 ATP binding site [chemical binding]; other site 369723009745 Q-loop/lid; other site 369723009746 ABC transporter signature motif; other site 369723009747 Walker B; other site 369723009748 D-loop; other site 369723009749 H-loop/switch region; other site 369723009750 ABC-2 type transporter; Region: ABC2_membrane; cl17235 369723009751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723009752 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723009753 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 369723009754 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 369723009755 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 369723009756 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 369723009757 hinge; other site 369723009758 active site 369723009759 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 369723009760 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 369723009761 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 369723009762 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 369723009763 gamma subunit interface [polypeptide binding]; other site 369723009764 epsilon subunit interface [polypeptide binding]; other site 369723009765 LBP interface [polypeptide binding]; other site 369723009766 Transcriptional regulator [Transcription]; Region: LytR; COG1316 369723009767 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 369723009768 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 369723009769 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 369723009770 alpha subunit interaction interface [polypeptide binding]; other site 369723009771 Walker A motif; other site 369723009772 ATP binding site [chemical binding]; other site 369723009773 Walker B motif; other site 369723009774 inhibitor binding site; inhibition site 369723009775 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 369723009776 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 369723009777 core domain interface [polypeptide binding]; other site 369723009778 delta subunit interface [polypeptide binding]; other site 369723009779 epsilon subunit interface [polypeptide binding]; other site 369723009780 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 369723009781 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 369723009782 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 369723009783 beta subunit interaction interface [polypeptide binding]; other site 369723009784 Walker A motif; other site 369723009785 ATP binding site [chemical binding]; other site 369723009786 Walker B motif; other site 369723009787 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 369723009788 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 369723009789 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 369723009790 ATP synthase subunit C; Region: ATP-synt_C; cl00466 369723009791 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 369723009792 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 369723009793 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 369723009794 Transglycosylase; Region: Transgly; pfam00912 369723009795 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 369723009796 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 369723009797 Low molecular weight phosphatase family; Region: LMWPc; cl00105 369723009798 active site 369723009799 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 369723009800 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 369723009801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723009802 S-adenosylmethionine binding site [chemical binding]; other site 369723009803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723009804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723009805 metal binding site [ion binding]; metal-binding site 369723009806 active site 369723009807 I-site; other site 369723009808 peptide chain release factor 1; Validated; Region: prfA; PRK00591 369723009809 This domain is found in peptide chain release factors; Region: PCRF; smart00937 369723009810 RF-1 domain; Region: RF-1; pfam00472 369723009811 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 369723009812 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 369723009813 transcription termination factor Rho; Provisional; Region: PRK12608 369723009814 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 369723009815 RNA binding site [nucleotide binding]; other site 369723009816 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 369723009817 Walker A motif; other site 369723009818 ATP binding site [chemical binding]; other site 369723009819 Walker B motif; other site 369723009820 homoserine kinase; Provisional; Region: PRK01212 369723009821 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 369723009822 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723009823 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 369723009824 threonine synthase; Reviewed; Region: PRK06721 369723009825 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 369723009826 homodimer interface [polypeptide binding]; other site 369723009827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723009828 catalytic residue [active] 369723009829 homoserine dehydrogenase; Provisional; Region: PRK06349 369723009830 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 369723009831 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 369723009832 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 369723009833 diaminopimelate decarboxylase; Region: lysA; TIGR01048 369723009834 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 369723009835 active site 369723009836 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 369723009837 substrate binding site [chemical binding]; other site 369723009838 catalytic residues [active] 369723009839 dimer interface [polypeptide binding]; other site 369723009840 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 369723009841 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 369723009842 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 369723009843 active site 369723009844 HIGH motif; other site 369723009845 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723009846 KMSK motif region; other site 369723009847 tRNA binding surface [nucleotide binding]; other site 369723009848 DALR anticodon binding domain; Region: DALR_1; smart00836 369723009849 anticodon binding site; other site 369723009850 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 369723009851 Domain of unknown function (DUF305); Region: DUF305; pfam03713 369723009852 Winged helix-turn helix; Region: HTH_33; pfam13592 369723009853 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723009854 Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170 369723009855 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 369723009856 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 369723009857 RHS Repeat; Region: RHS_repeat; pfam05593 369723009858 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 369723009859 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 369723009860 tetramer interface [polypeptide binding]; other site 369723009861 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 369723009862 active site 369723009863 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 369723009864 nucleotide binding site [chemical binding]; other site 369723009865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723009866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723009867 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 369723009868 Erythromycin esterase; Region: Erythro_esteras; pfam05139 369723009869 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 369723009870 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 369723009871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723009872 S-adenosylmethionine binding site [chemical binding]; other site 369723009873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 369723009874 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 369723009875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723009876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 369723009877 NAD(P) binding site [chemical binding]; other site 369723009878 active site 369723009879 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 369723009880 active site 369723009881 catalytic residues [active] 369723009882 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 369723009883 metal binding site [ion binding]; metal-binding site 369723009884 ligand binding site [chemical binding]; other site 369723009885 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 369723009886 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723009887 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 369723009888 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 369723009889 Amidinotransferase; Region: Amidinotransf; pfam02274 369723009890 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 369723009891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723009892 inhibitor-cofactor binding pocket; inhibition site 369723009893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723009894 catalytic residue [active] 369723009895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 369723009896 phosphopeptide binding site; other site 369723009897 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 369723009898 Fatty acid desaturase; Region: FA_desaturase; pfam00487 369723009899 putative di-iron ligands [ion binding]; other site 369723009900 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 369723009901 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 369723009902 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 369723009903 putative acyl-acceptor binding pocket; other site 369723009904 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 369723009905 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 369723009906 nucleophile elbow; other site 369723009907 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 369723009908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723009909 putative ADP-binding pocket [chemical binding]; other site 369723009910 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 369723009911 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 369723009912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723009913 dimerization interface [polypeptide binding]; other site 369723009914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723009915 dimer interface [polypeptide binding]; other site 369723009916 phosphorylation site [posttranslational modification] 369723009917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723009918 ATP binding site [chemical binding]; other site 369723009919 Mg2+ binding site [ion binding]; other site 369723009920 G-X-G motif; other site 369723009921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723009922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723009923 active site 369723009924 phosphorylation site [posttranslational modification] 369723009925 intermolecular recognition site; other site 369723009926 dimerization interface [polypeptide binding]; other site 369723009927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723009928 DNA binding site [nucleotide binding] 369723009929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723009930 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 369723009931 Walker A/P-loop; other site 369723009932 ATP binding site [chemical binding]; other site 369723009933 Q-loop/lid; other site 369723009934 ABC transporter signature motif; other site 369723009935 Walker B; other site 369723009936 D-loop; other site 369723009937 H-loop/switch region; other site 369723009938 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 369723009939 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 369723009940 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 369723009941 TPP-binding site [chemical binding]; other site 369723009942 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 369723009943 phosphate acetyltransferase; Reviewed; Region: PRK05632 369723009944 DRTGG domain; Region: DRTGG; pfam07085 369723009945 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 369723009946 Acetokinase family; Region: Acetate_kinase; cl17229 369723009947 propionate/acetate kinase; Provisional; Region: PRK12379 369723009948 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 369723009949 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 369723009950 NAD(P) binding site [chemical binding]; other site 369723009951 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 369723009952 Malic enzyme, N-terminal domain; Region: malic; pfam00390 369723009953 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 369723009954 NAD(P) binding pocket [chemical binding]; other site 369723009955 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 369723009956 Catalytic site [active] 369723009957 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 369723009958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 369723009959 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 369723009960 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 369723009961 Transcription factor WhiB; Region: Whib; pfam02467 369723009962 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 369723009963 putative active site [active] 369723009964 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 369723009965 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 369723009966 Active Sites [active] 369723009967 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 369723009968 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 369723009969 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 369723009970 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 369723009971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 369723009972 Histidine kinase; Region: HisKA_2; pfam07568 369723009973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723009974 ATP binding site [chemical binding]; other site 369723009975 Mg2+ binding site [ion binding]; other site 369723009976 G-X-G motif; other site 369723009977 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 369723009978 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 369723009979 dimer interface [polypeptide binding]; other site 369723009980 active site 369723009981 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 369723009982 dimer interface [polypeptide binding]; other site 369723009983 active site 369723009984 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 369723009985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 369723009986 TPR motif; other site 369723009987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723009988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723009989 putative substrate translocation pore; other site 369723009990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723009991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723009992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723009993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 369723009994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723009995 Coenzyme A binding pocket [chemical binding]; other site 369723009996 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 369723009997 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 369723009998 carboxyltransferase (CT) interaction site; other site 369723009999 biotinylation site [posttranslational modification]; other site 369723010000 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 369723010001 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 369723010002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723010003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723010004 DNA binding residues [nucleotide binding] 369723010005 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 369723010006 Transcription factor WhiB; Region: Whib; pfam02467 369723010007 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 369723010008 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 369723010009 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 369723010010 hinge; other site 369723010011 active site 369723010012 Predicted GTPases [General function prediction only]; Region: COG1162 369723010013 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 369723010014 GTPase/Zn-binding domain interface [polypeptide binding]; other site 369723010015 GTP/Mg2+ binding site [chemical binding]; other site 369723010016 G4 box; other site 369723010017 G5 box; other site 369723010018 G1 box; other site 369723010019 Switch I region; other site 369723010020 G2 box; other site 369723010021 G3 box; other site 369723010022 Switch II region; other site 369723010023 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 369723010024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 369723010025 active site 369723010026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723010027 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 369723010028 putative ADP-binding pocket [chemical binding]; other site 369723010029 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 369723010030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723010031 ATP binding site [chemical binding]; other site 369723010032 Mg2+ binding site [ion binding]; other site 369723010033 G-X-G motif; other site 369723010034 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 369723010035 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 369723010036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723010037 active site 369723010038 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 369723010039 ATP binding site [chemical binding]; other site 369723010040 active site 369723010041 substrate binding site [chemical binding]; other site 369723010042 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 369723010043 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 369723010044 NADP+ binding site [chemical binding]; other site 369723010045 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 369723010046 hypothetical protein; Validated; Region: PRK00068 369723010047 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 369723010048 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 369723010049 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 369723010050 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 369723010051 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 369723010052 Protein of unknown function DUF45; Region: DUF45; pfam01863 369723010053 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 369723010054 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 369723010055 ATP binding site [chemical binding]; other site 369723010056 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 369723010057 ABC1 family; Region: ABC1; cl17513 369723010058 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 369723010059 active site 369723010060 ATP binding site [chemical binding]; other site 369723010061 Transcription factor WhiB; Region: Whib; pfam02467 369723010062 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 369723010063 Part of AAA domain; Region: AAA_19; pfam13245 369723010064 Family description; Region: UvrD_C_2; pfam13538 369723010065 HRDC domain; Region: HRDC; pfam00570 369723010066 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 369723010067 catalytic residues [active] 369723010068 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723010069 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 369723010070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723010071 sequence-specific DNA binding site [nucleotide binding]; other site 369723010072 salt bridge; other site 369723010073 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723010074 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 369723010075 putative NADH binding site [chemical binding]; other site 369723010076 putative active site [active] 369723010077 nudix motif; other site 369723010078 putative metal binding site [ion binding]; other site 369723010079 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 369723010080 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 369723010081 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723010082 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 369723010083 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 369723010084 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 369723010085 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 369723010086 Part of AAA domain; Region: AAA_19; pfam13245 369723010087 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 369723010088 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 369723010089 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 369723010090 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 369723010091 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 369723010092 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 369723010093 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 369723010094 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 369723010095 metal binding site [ion binding]; metal-binding site 369723010096 putative dimer interface [polypeptide binding]; other site 369723010097 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 369723010098 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 369723010099 putative trimer interface [polypeptide binding]; other site 369723010100 putative CoA binding site [chemical binding]; other site 369723010101 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723010102 Peptidase S8 family domain, uncharacterized subfamily 6; Region: Peptidases_S8_6; cd07490 369723010103 active site 369723010104 catalytic triad [active] 369723010105 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 369723010106 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 369723010107 Prephenate dehydrogenase; Region: PDH; pfam02153 369723010108 prephenate dehydrogenase; Validated; Region: PRK08507 369723010109 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 369723010110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723010111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723010112 homodimer interface [polypeptide binding]; other site 369723010113 catalytic residue [active] 369723010114 Ferredoxin [Energy production and conversion]; Region: COG1146 369723010115 4Fe-4S binding domain; Region: Fer4; pfam00037 369723010116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723010117 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 369723010118 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 369723010119 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 369723010120 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723010121 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 369723010122 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 369723010123 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 369723010124 L-aspartate oxidase; Provisional; Region: PRK06175 369723010125 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 369723010126 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 369723010127 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 369723010128 catalytic loop [active] 369723010129 iron binding site [ion binding]; other site 369723010130 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 369723010131 active site 369723010132 8-oxo-dGMP binding site [chemical binding]; other site 369723010133 nudix motif; other site 369723010134 metal binding site [ion binding]; metal-binding site 369723010135 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 369723010136 Pleckstrin homology-like domain; Region: PH-like; cl17171 369723010137 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 369723010138 active site 369723010139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 369723010140 non-specific DNA binding site [nucleotide binding]; other site 369723010141 salt bridge; other site 369723010142 sequence-specific DNA binding site [nucleotide binding]; other site 369723010143 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 369723010144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723010145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723010146 DNA binding residues [nucleotide binding] 369723010147 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 369723010148 Active_site [active] 369723010149 Penicillin amidase; Region: Penicil_amidase; pfam01804 369723010150 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 369723010151 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 369723010152 active site 369723010153 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 369723010154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723010155 Coenzyme A binding pocket [chemical binding]; other site 369723010156 Protein of unknown function (DUF418); Region: DUF418; cl12135 369723010157 GTP-binding protein YchF; Reviewed; Region: PRK09601 369723010158 YchF GTPase; Region: YchF; cd01900 369723010159 G1 box; other site 369723010160 GTP/Mg2+ binding site [chemical binding]; other site 369723010161 Switch I region; other site 369723010162 G2 box; other site 369723010163 Switch II region; other site 369723010164 G3 box; other site 369723010165 G4 box; other site 369723010166 G5 box; other site 369723010167 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 369723010168 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 369723010169 active site pocket [active] 369723010170 oxyanion hole [active] 369723010171 catalytic triad [active] 369723010172 active site nucleophile [active] 369723010173 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 369723010174 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 369723010175 AlkA N-terminal domain; Region: AlkA_N; pfam06029 369723010176 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 369723010177 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 369723010178 helix-hairpin-helix signature motif; other site 369723010179 substrate binding pocket [chemical binding]; other site 369723010180 active site 369723010181 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 369723010182 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 369723010183 active site 369723010184 DNA binding site [nucleotide binding] 369723010185 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723010186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723010187 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723010188 Walker A/P-loop; other site 369723010189 ATP binding site [chemical binding]; other site 369723010190 Q-loop/lid; other site 369723010191 ABC transporter signature motif; other site 369723010192 Walker B; other site 369723010193 D-loop; other site 369723010194 H-loop/switch region; other site 369723010195 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723010196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723010197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723010198 Walker A/P-loop; other site 369723010199 ATP binding site [chemical binding]; other site 369723010200 Q-loop/lid; other site 369723010201 ABC transporter signature motif; other site 369723010202 Walker B; other site 369723010203 D-loop; other site 369723010204 H-loop/switch region; other site 369723010205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723010206 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723010207 Walker A/P-loop; other site 369723010208 ATP binding site [chemical binding]; other site 369723010209 Q-loop/lid; other site 369723010210 ABC transporter signature motif; other site 369723010211 Walker B; other site 369723010212 D-loop; other site 369723010213 H-loop/switch region; other site 369723010214 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 369723010215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723010216 Walker A/P-loop; other site 369723010217 ATP binding site [chemical binding]; other site 369723010218 Q-loop/lid; other site 369723010219 ABC transporter signature motif; other site 369723010220 Walker B; other site 369723010221 D-loop; other site 369723010222 H-loop/switch region; other site 369723010223 Electron transfer DM13; Region: DM13; pfam10517 369723010224 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 369723010225 PUA-like domain; Region: PUA_2; pfam14306 369723010226 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 369723010227 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 369723010228 ligand-binding site [chemical binding]; other site 369723010229 isocitrate dehydrogenase; Validated; Region: PRK08299 369723010230 malate dehydrogenase; Reviewed; Region: PRK06223 369723010231 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 369723010232 NAD(P) binding site [chemical binding]; other site 369723010233 dimer interface [polypeptide binding]; other site 369723010234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 369723010235 substrate binding site [chemical binding]; other site 369723010236 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 369723010237 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 369723010238 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 369723010239 homodimer interface [polypeptide binding]; other site 369723010240 NADP binding site [chemical binding]; other site 369723010241 substrate binding site [chemical binding]; other site 369723010242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 369723010243 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 369723010244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723010245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723010246 dimer interface [polypeptide binding]; other site 369723010247 conserved gate region; other site 369723010248 putative PBP binding loops; other site 369723010249 ABC-ATPase subunit interface; other site 369723010250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 369723010251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723010252 dimer interface [polypeptide binding]; other site 369723010253 conserved gate region; other site 369723010254 putative PBP binding loops; other site 369723010255 ABC-ATPase subunit interface; other site 369723010256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 369723010257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723010258 Walker A/P-loop; other site 369723010259 ATP binding site [chemical binding]; other site 369723010260 Q-loop/lid; other site 369723010261 ABC transporter signature motif; other site 369723010262 Walker B; other site 369723010263 D-loop; other site 369723010264 H-loop/switch region; other site 369723010265 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 369723010266 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 369723010267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723010268 Walker A/P-loop; other site 369723010269 ATP binding site [chemical binding]; other site 369723010270 Q-loop/lid; other site 369723010271 ABC transporter signature motif; other site 369723010272 Walker B; other site 369723010273 D-loop; other site 369723010274 H-loop/switch region; other site 369723010275 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 369723010276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723010277 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 369723010278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723010279 putative DNA binding site [nucleotide binding]; other site 369723010280 putative Zn2+ binding site [ion binding]; other site 369723010281 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 369723010282 classical (c) SDRs; Region: SDR_c; cd05233 369723010283 NAD(P) binding site [chemical binding]; other site 369723010284 active site 369723010285 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 369723010286 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 369723010287 purine monophosphate binding site [chemical binding]; other site 369723010288 dimer interface [polypeptide binding]; other site 369723010289 putative catalytic residues [active] 369723010290 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 369723010291 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 369723010292 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 369723010293 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 369723010294 active site 369723010295 substrate binding site [chemical binding]; other site 369723010296 cosubstrate binding site; other site 369723010297 catalytic site [active] 369723010298 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 369723010299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 369723010300 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 369723010301 CoA binding domain; Region: CoA_binding; smart00881 369723010302 CoA-ligase; Region: Ligase_CoA; pfam00549 369723010303 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 369723010304 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 369723010305 CoA-ligase; Region: Ligase_CoA; pfam00549 369723010306 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 369723010307 B12 binding site [chemical binding]; other site 369723010308 cobalt ligand [ion binding]; other site 369723010309 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 369723010310 Peptidase family M23; Region: Peptidase_M23; pfam01551 369723010311 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 369723010312 Peptidase family M23; Region: Peptidase_M23; pfam01551 369723010313 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 369723010314 Part of AAA domain; Region: AAA_19; pfam13245 369723010315 Family description; Region: UvrD_C_2; pfam13538 369723010316 Chorismate mutase type II; Region: CM_2; cl00693 369723010317 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 369723010318 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723010319 Walker A/P-loop; other site 369723010320 ATP binding site [chemical binding]; other site 369723010321 Q-loop/lid; other site 369723010322 ABC transporter signature motif; other site 369723010323 Walker B; other site 369723010324 D-loop; other site 369723010325 H-loop/switch region; other site 369723010326 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 369723010327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 369723010328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723010329 Walker A/P-loop; other site 369723010330 ATP binding site [chemical binding]; other site 369723010331 Q-loop/lid; other site 369723010332 ABC transporter signature motif; other site 369723010333 Walker B; other site 369723010334 D-loop; other site 369723010335 H-loop/switch region; other site 369723010336 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 369723010337 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 369723010338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723010339 dimer interface [polypeptide binding]; other site 369723010340 conserved gate region; other site 369723010341 putative PBP binding loops; other site 369723010342 ABC-ATPase subunit interface; other site 369723010343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723010344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723010345 dimer interface [polypeptide binding]; other site 369723010346 conserved gate region; other site 369723010347 putative PBP binding loops; other site 369723010348 ABC-ATPase subunit interface; other site 369723010349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 369723010350 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 369723010351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723010352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723010353 active site 369723010354 phosphorylation site [posttranslational modification] 369723010355 intermolecular recognition site; other site 369723010356 dimerization interface [polypeptide binding]; other site 369723010357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723010358 DNA binding residues [nucleotide binding] 369723010359 dimerization interface [polypeptide binding]; other site 369723010360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723010361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723010362 ATP binding site [chemical binding]; other site 369723010363 G-X-G motif; other site 369723010364 PspC domain; Region: PspC; pfam04024 369723010365 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 369723010366 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 369723010367 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723010368 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723010369 nudix motif; other site 369723010370 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723010371 nudix motif; other site 369723010372 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 369723010373 nudix motif; other site 369723010374 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723010375 nudix motif; other site 369723010376 GMP synthase; Reviewed; Region: guaA; PRK00074 369723010377 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 369723010378 AMP/PPi binding site [chemical binding]; other site 369723010379 candidate oxyanion hole; other site 369723010380 catalytic triad [active] 369723010381 potential glutamine specificity residues [chemical binding]; other site 369723010382 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 369723010383 ATP Binding subdomain [chemical binding]; other site 369723010384 Ligand Binding sites [chemical binding]; other site 369723010385 Dimerization subdomain; other site 369723010386 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 369723010387 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 369723010388 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 369723010389 Peptidase family M1; Region: Peptidase_M1; pfam01433 369723010390 Zn binding site [ion binding]; other site 369723010391 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 369723010392 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 369723010393 phosphate binding site [ion binding]; other site 369723010394 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 369723010395 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 369723010396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 369723010397 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 369723010398 active site 369723010399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723010400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723010401 DNA binding residues [nucleotide binding] 369723010402 dimerization interface [polypeptide binding]; other site 369723010403 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 369723010404 Moco binding site; other site 369723010405 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 369723010406 metal coordination site [ion binding]; other site 369723010407 dimerization interface [polypeptide binding]; other site 369723010408 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 369723010409 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 369723010410 ring oligomerisation interface [polypeptide binding]; other site 369723010411 ATP/Mg binding site [chemical binding]; other site 369723010412 stacking interactions; other site 369723010413 hinge regions; other site 369723010414 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 369723010415 oligomerisation interface [polypeptide binding]; other site 369723010416 mobile loop; other site 369723010417 roof hairpin; other site 369723010418 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 369723010419 putative deacylase active site [active] 369723010420 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 369723010421 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 369723010422 putative ligand binding site [chemical binding]; other site 369723010423 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 369723010424 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 369723010425 Walker A/P-loop; other site 369723010426 ATP binding site [chemical binding]; other site 369723010427 Q-loop/lid; other site 369723010428 ABC transporter signature motif; other site 369723010429 Walker B; other site 369723010430 D-loop; other site 369723010431 H-loop/switch region; other site 369723010432 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723010433 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 369723010434 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 369723010435 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 369723010436 TM-ABC transporter signature motif; other site 369723010437 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 369723010438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723010439 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 369723010440 UGMP family protein; Validated; Region: PRK09604 369723010441 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 369723010442 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 369723010443 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 369723010444 Glycoprotease family; Region: Peptidase_M22; pfam00814 369723010445 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 369723010446 ligand binding site [chemical binding]; other site 369723010447 active site 369723010448 UGI interface [polypeptide binding]; other site 369723010449 catalytic site [active] 369723010450 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 369723010451 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723010452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723010453 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 369723010454 alanine racemase; Reviewed; Region: alr; PRK00053 369723010455 active site 369723010456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 369723010457 dimer interface [polypeptide binding]; other site 369723010458 substrate binding site [chemical binding]; other site 369723010459 catalytic residues [active] 369723010460 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 369723010461 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 369723010462 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 369723010463 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 369723010464 glutaminase active site [active] 369723010465 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 369723010466 dimer interface [polypeptide binding]; other site 369723010467 active site 369723010468 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 369723010469 dimer interface [polypeptide binding]; other site 369723010470 active site 369723010471 aminotransferase; Validated; Region: PRK07777 369723010472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723010473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723010474 homodimer interface [polypeptide binding]; other site 369723010475 catalytic residue [active] 369723010476 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 369723010477 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 369723010478 active site 369723010479 substrate binding site [chemical binding]; other site 369723010480 metal binding site [ion binding]; metal-binding site 369723010481 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 369723010482 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 369723010483 23S rRNA interface [nucleotide binding]; other site 369723010484 L3 interface [polypeptide binding]; other site 369723010485 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 369723010486 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 369723010487 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 369723010488 [4Fe-4S] binding site [ion binding]; other site 369723010489 molybdopterin cofactor binding site; other site 369723010490 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 369723010491 molybdopterin cofactor binding site; other site 369723010492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 369723010493 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 369723010494 nitrite reductase subunit NirD; Provisional; Region: PRK14989 369723010495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723010496 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 369723010497 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 369723010498 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 369723010499 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 369723010500 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 369723010501 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 369723010502 active site 369723010503 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 369723010504 DNA binding site [nucleotide binding] 369723010505 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 369723010506 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 369723010507 G1 box; other site 369723010508 GTP/Mg2+ binding site [chemical binding]; other site 369723010509 G2 box; other site 369723010510 Switch I region; other site 369723010511 G3 box; other site 369723010512 Switch II region; other site 369723010513 G4 box; other site 369723010514 G5 box; other site 369723010515 Protein of unknown function (DUF742); Region: DUF742; pfam05331 369723010516 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 369723010517 Nitrate and nitrite sensing; Region: NIT; pfam08376 369723010518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723010519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723010520 ATP binding site [chemical binding]; other site 369723010521 Mg2+ binding site [ion binding]; other site 369723010522 G-X-G motif; other site 369723010523 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 369723010524 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 369723010525 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 369723010526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723010527 dimer interface [polypeptide binding]; other site 369723010528 conserved gate region; other site 369723010529 putative PBP binding loops; other site 369723010530 ABC-ATPase subunit interface; other site 369723010531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 369723010532 NMT1/THI5 like; Region: NMT1; pfam09084 369723010533 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 369723010534 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 369723010535 Walker A/P-loop; other site 369723010536 ATP binding site [chemical binding]; other site 369723010537 Q-loop/lid; other site 369723010538 ABC transporter signature motif; other site 369723010539 Walker B; other site 369723010540 D-loop; other site 369723010541 H-loop/switch region; other site 369723010542 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 369723010543 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723010544 Cupin domain; Region: Cupin_2; cl17218 369723010545 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 369723010546 ThiC-associated domain; Region: ThiC-associated; pfam13667 369723010547 ThiC family; Region: ThiC; pfam01964 369723010548 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 369723010549 dimer interface [polypeptide binding]; other site 369723010550 substrate binding site [chemical binding]; other site 369723010551 ATP binding site [chemical binding]; other site 369723010552 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 369723010553 thiamine phosphate binding site [chemical binding]; other site 369723010554 active site 369723010555 pyrophosphate binding site [ion binding]; other site 369723010556 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 369723010557 ThiS interaction site; other site 369723010558 putative active site [active] 369723010559 tetramer interface [polypeptide binding]; other site 369723010560 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 369723010561 thiS-thiF/thiG interaction site; other site 369723010562 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 369723010563 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 369723010564 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 369723010565 thiamine phosphate binding site [chemical binding]; other site 369723010566 active site 369723010567 pyrophosphate binding site [ion binding]; other site 369723010568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 369723010569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 369723010570 active site 369723010571 catalytic tetrad [active] 369723010572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723010573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 369723010574 Walker A/P-loop; other site 369723010575 ATP binding site [chemical binding]; other site 369723010576 Q-loop/lid; other site 369723010577 ABC transporter signature motif; other site 369723010578 Walker B; other site 369723010579 D-loop; other site 369723010580 H-loop/switch region; other site 369723010581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 369723010582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723010583 S-adenosylmethionine binding site [chemical binding]; other site 369723010584 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 369723010585 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 369723010586 dimerization interface 3.5A [polypeptide binding]; other site 369723010587 active site 369723010588 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 369723010589 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 369723010590 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 369723010591 alphaNTD homodimer interface [polypeptide binding]; other site 369723010592 alphaNTD - beta interaction site [polypeptide binding]; other site 369723010593 alphaNTD - beta' interaction site [polypeptide binding]; other site 369723010594 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 369723010595 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 369723010596 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 369723010597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 369723010598 RNA binding surface [nucleotide binding]; other site 369723010599 30S ribosomal protein S11; Validated; Region: PRK05309 369723010600 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 369723010601 30S ribosomal protein S13; Region: bact_S13; TIGR03631 369723010602 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 369723010603 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 369723010604 rRNA binding site [nucleotide binding]; other site 369723010605 predicted 30S ribosome binding site; other site 369723010606 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 369723010607 active site 369723010608 adenylate kinase; Reviewed; Region: adk; PRK00279 369723010609 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 369723010610 AMP-binding site [chemical binding]; other site 369723010611 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 369723010612 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 369723010613 SecY translocase; Region: SecY; pfam00344 369723010614 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 369723010615 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 369723010616 23S rRNA binding site [nucleotide binding]; other site 369723010617 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 369723010618 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 369723010619 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 369723010620 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 369723010621 23S rRNA interface [nucleotide binding]; other site 369723010622 5S rRNA interface [nucleotide binding]; other site 369723010623 L27 interface [polypeptide binding]; other site 369723010624 L5 interface [polypeptide binding]; other site 369723010625 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 369723010626 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 369723010627 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 369723010628 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 369723010629 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 369723010630 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 369723010631 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 369723010632 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 369723010633 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 369723010634 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 369723010635 RNA binding site [nucleotide binding]; other site 369723010636 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 369723010637 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 369723010638 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 369723010639 putative translocon interaction site; other site 369723010640 signal recognition particle (SRP54) interaction site; other site 369723010641 L23 interface [polypeptide binding]; other site 369723010642 trigger factor interaction site; other site 369723010643 23S rRNA interface [nucleotide binding]; other site 369723010644 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 369723010645 23S rRNA interface [nucleotide binding]; other site 369723010646 5S rRNA interface [nucleotide binding]; other site 369723010647 putative antibiotic binding site [chemical binding]; other site 369723010648 L25 interface [polypeptide binding]; other site 369723010649 L27 interface [polypeptide binding]; other site 369723010650 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 369723010651 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 369723010652 G-X-X-G motif; other site 369723010653 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 369723010654 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 369723010655 putative translocon binding site; other site 369723010656 protein-rRNA interface [nucleotide binding]; other site 369723010657 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 369723010658 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 369723010659 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 369723010660 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 369723010661 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 369723010662 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 369723010663 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 369723010664 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 369723010665 elongation factor Tu; Reviewed; Region: PRK00049 369723010666 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 369723010667 G1 box; other site 369723010668 GEF interaction site [polypeptide binding]; other site 369723010669 GTP/Mg2+ binding site [chemical binding]; other site 369723010670 Switch I region; other site 369723010671 G2 box; other site 369723010672 G3 box; other site 369723010673 Switch II region; other site 369723010674 G4 box; other site 369723010675 G5 box; other site 369723010676 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 369723010677 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 369723010678 Antibiotic Binding Site [chemical binding]; other site 369723010679 elongation factor G; Reviewed; Region: PRK00007 369723010680 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 369723010681 G1 box; other site 369723010682 putative GEF interaction site [polypeptide binding]; other site 369723010683 GTP/Mg2+ binding site [chemical binding]; other site 369723010684 Switch I region; other site 369723010685 G2 box; other site 369723010686 G3 box; other site 369723010687 Switch II region; other site 369723010688 G4 box; other site 369723010689 G5 box; other site 369723010690 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 369723010691 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 369723010692 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 369723010693 30S ribosomal protein S7; Validated; Region: PRK05302 369723010694 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 369723010695 S17 interaction site [polypeptide binding]; other site 369723010696 S8 interaction site; other site 369723010697 16S rRNA interaction site [nucleotide binding]; other site 369723010698 streptomycin interaction site [chemical binding]; other site 369723010699 23S rRNA interaction site [nucleotide binding]; other site 369723010700 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 369723010701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723010702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723010703 active site 369723010704 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 369723010705 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 369723010706 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 369723010707 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 369723010708 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 369723010709 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 369723010710 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 369723010711 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 369723010712 G-loop; other site 369723010713 DNA binding site [nucleotide binding] 369723010714 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 369723010715 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 369723010716 RPB12 interaction site [polypeptide binding]; other site 369723010717 RPB1 interaction site [polypeptide binding]; other site 369723010718 RPB10 interaction site [polypeptide binding]; other site 369723010719 RPB11 interaction site [polypeptide binding]; other site 369723010720 RPB3 interaction site [polypeptide binding]; other site 369723010721 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 369723010722 core dimer interface [polypeptide binding]; other site 369723010723 peripheral dimer interface [polypeptide binding]; other site 369723010724 L10 interface [polypeptide binding]; other site 369723010725 L11 interface [polypeptide binding]; other site 369723010726 putative EF-Tu interaction site [polypeptide binding]; other site 369723010727 putative EF-G interaction site [polypeptide binding]; other site 369723010728 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 369723010729 23S rRNA interface [nucleotide binding]; other site 369723010730 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 369723010731 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 369723010732 mRNA/rRNA interface [nucleotide binding]; other site 369723010733 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 369723010734 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 369723010735 23S rRNA interface [nucleotide binding]; other site 369723010736 L7/L12 interface [polypeptide binding]; other site 369723010737 putative thiostrepton binding site; other site 369723010738 L25 interface [polypeptide binding]; other site 369723010739 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 369723010740 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 369723010741 putative homodimer interface [polypeptide binding]; other site 369723010742 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 369723010743 heterodimer interface [polypeptide binding]; other site 369723010744 homodimer interface [polypeptide binding]; other site 369723010745 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 369723010746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 369723010747 active site 2 [active] 369723010748 active site 1 [active] 369723010749 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 369723010750 active site 369723010751 catalytic site [active] 369723010752 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 369723010753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 369723010754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 369723010755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 369723010756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 369723010757 metal binding site [ion binding]; metal-binding site 369723010758 active site 369723010759 I-site; other site 369723010760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 369723010761 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723010762 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 369723010763 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 369723010764 DNA-binding site [nucleotide binding]; DNA binding site 369723010765 RNA-binding motif; other site 369723010766 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 369723010767 WYL domain; Region: WYL; pfam13280 369723010768 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 369723010769 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 369723010770 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 369723010771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723010772 ATP binding site [chemical binding]; other site 369723010773 putative Mg++ binding site [ion binding]; other site 369723010774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723010775 nucleotide binding region [chemical binding]; other site 369723010776 ATP-binding site [chemical binding]; other site 369723010777 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 369723010778 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 369723010779 PYR/PP interface [polypeptide binding]; other site 369723010780 dimer interface [polypeptide binding]; other site 369723010781 TPP binding site [chemical binding]; other site 369723010782 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 369723010783 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 369723010784 TPP-binding site [chemical binding]; other site 369723010785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723010786 DNA-binding site [nucleotide binding]; DNA binding site 369723010787 Double zinc ribbon; Region: DZR; pfam12773 369723010788 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 369723010789 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 369723010790 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723010791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723010792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723010793 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 369723010794 DNA-binding site [nucleotide binding]; DNA binding site 369723010795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723010796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723010797 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 369723010798 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 369723010799 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 369723010800 active site 369723010801 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 369723010802 nucleotide binding site [chemical binding]; other site 369723010803 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 369723010804 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 369723010805 active site 369723010806 DNA binding site [nucleotide binding] 369723010807 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 369723010808 DNA binding site [nucleotide binding] 369723010809 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 369723010810 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 369723010811 putative DNA binding site [nucleotide binding]; other site 369723010812 putative homodimer interface [polypeptide binding]; other site 369723010813 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 369723010814 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 369723010815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 369723010816 motif I; other site 369723010817 active site 369723010818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723010819 motif II; other site 369723010820 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 369723010821 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 369723010822 dimer interface [polypeptide binding]; other site 369723010823 acyl-activating enzyme (AAE) consensus motif; other site 369723010824 putative active site [active] 369723010825 AMP binding site [chemical binding]; other site 369723010826 putative CoA binding site [chemical binding]; other site 369723010827 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 369723010828 nudix motif; other site 369723010829 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 369723010830 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 369723010831 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 369723010832 active site 369723010833 nucleotide binding site [chemical binding]; other site 369723010834 HIGH motif; other site 369723010835 KMSKS motif; other site 369723010836 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 369723010837 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 369723010838 active site 369723010839 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 369723010840 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 369723010841 putative active site [active] 369723010842 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 369723010843 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 369723010844 putative dimer interface [polypeptide binding]; other site 369723010845 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 369723010846 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 369723010847 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 369723010848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723010849 active site 369723010850 OsmC-like protein; Region: OsmC; cl00767 369723010851 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 369723010852 Beta-lactamase; Region: Beta-lactamase; pfam00144 369723010853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723010854 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 369723010855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723010856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723010857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723010858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723010859 TAP-like protein; Region: Abhydrolase_4; pfam08386 369723010860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723010861 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723010862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723010863 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 369723010864 dinuclear metal binding motif [ion binding]; other site 369723010865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723010866 Walker A motif; other site 369723010867 ATP binding site [chemical binding]; other site 369723010868 Walker B motif; other site 369723010869 RecT family; Region: RecT; pfam03837 369723010870 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 369723010871 Prophage antirepressor [Transcription]; Region: COG3617 369723010872 BRO family, N-terminal domain; Region: Bro-N; smart01040 369723010873 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 369723010874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723010875 non-specific DNA binding site [nucleotide binding]; other site 369723010876 salt bridge; other site 369723010877 sequence-specific DNA binding site [nucleotide binding]; other site 369723010878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723010879 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 369723010880 Int/Topo IB signature motif; other site 369723010881 DNA binding site [nucleotide binding] 369723010882 active site 369723010883 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723010884 PSP1 C-terminal conserved region; Region: PSP1; cl00770 369723010885 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 369723010886 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 369723010887 DNA polymerase III subunit delta'; Validated; Region: PRK08485 369723010888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723010889 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723010890 thymidylate kinase; Validated; Region: tmk; PRK00698 369723010891 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 369723010892 TMP-binding site; other site 369723010893 ATP-binding site [chemical binding]; other site 369723010894 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 369723010895 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 369723010896 dimer interface [polypeptide binding]; other site 369723010897 active site 369723010898 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 369723010899 substrate binding site [chemical binding]; other site 369723010900 catalytic residue [active] 369723010901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723010902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723010903 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 369723010904 FAD binding domain; Region: FAD_binding_4; pfam01565 369723010905 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 369723010906 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 369723010907 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 369723010908 active site 369723010909 interdomain interaction site; other site 369723010910 putative metal-binding site [ion binding]; other site 369723010911 nucleotide binding site [chemical binding]; other site 369723010912 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 369723010913 domain I; other site 369723010914 phosphate binding site [ion binding]; other site 369723010915 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 369723010916 domain II; other site 369723010917 domain III; other site 369723010918 nucleotide binding site [chemical binding]; other site 369723010919 DNA binding groove [nucleotide binding] 369723010920 catalytic site [active] 369723010921 domain IV; other site 369723010922 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 369723010923 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 369723010924 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 369723010925 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 369723010926 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 369723010927 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 369723010928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 369723010929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 369723010930 anti sigma factor interaction site; other site 369723010931 regulatory phosphorylation site [posttranslational modification]; other site 369723010932 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 369723010933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 369723010934 ATP binding site [chemical binding]; other site 369723010935 putative Mg++ binding site [ion binding]; other site 369723010936 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 369723010937 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 369723010938 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 369723010939 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 369723010940 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 369723010941 ATP binding site [chemical binding]; other site 369723010942 Walker B motif; other site 369723010943 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 369723010944 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 369723010945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723010946 motif II; other site 369723010947 acetyl-CoA synthetase; Provisional; Region: PRK00174 369723010948 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 369723010949 active site 369723010950 CoA binding site [chemical binding]; other site 369723010951 acyl-activating enzyme (AAE) consensus motif; other site 369723010952 AMP binding site [chemical binding]; other site 369723010953 acetate binding site [chemical binding]; other site 369723010954 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723010955 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723010956 cell division protein ZipA; Provisional; Region: PRK03427 369723010957 Membrane protein of unknown function; Region: DUF360; pfam04020 369723010958 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 369723010959 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 369723010960 Transcriptional regulator [Transcription]; Region: IclR; COG1414 369723010961 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 369723010962 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 369723010963 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 369723010964 substrate binding pocket [chemical binding]; other site 369723010965 chain length determination region; other site 369723010966 substrate-Mg2+ binding site; other site 369723010967 catalytic residues [active] 369723010968 aspartate-rich region 1; other site 369723010969 active site lid residues [active] 369723010970 aspartate-rich region 2; other site 369723010971 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 369723010972 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723010973 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 369723010974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723010975 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 369723010976 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 369723010977 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 369723010978 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 369723010979 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 369723010980 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 369723010981 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 369723010982 4Fe-4S binding domain; Region: Fer4; pfam00037 369723010983 4Fe-4S binding domain; Region: Fer4; pfam00037 369723010984 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 369723010985 NADH dehydrogenase subunit G; Validated; Region: PRK07860 369723010986 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 369723010987 catalytic loop [active] 369723010988 iron binding site [ion binding]; other site 369723010989 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 369723010990 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 369723010991 molybdopterin cofactor binding site; other site 369723010992 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 369723010993 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 369723010994 SLBB domain; Region: SLBB; pfam10531 369723010995 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 369723010996 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 369723010997 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 369723010998 putative dimer interface [polypeptide binding]; other site 369723010999 [2Fe-2S] cluster binding site [ion binding]; other site 369723011000 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 369723011001 NADH dehydrogenase subunit D; Validated; Region: PRK06075 369723011002 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 369723011003 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 369723011004 NADH dehydrogenase subunit B; Validated; Region: PRK06411 369723011005 NADH dehydrogenase subunit A; Validated; Region: PRK07928 369723011006 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 369723011007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 369723011008 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 369723011009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723011010 S-adenosylmethionine binding site [chemical binding]; other site 369723011011 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 369723011012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723011013 FeS/SAM binding site; other site 369723011014 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 369723011015 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 369723011016 FAD binding pocket [chemical binding]; other site 369723011017 FAD binding motif [chemical binding]; other site 369723011018 phosphate binding motif [ion binding]; other site 369723011019 beta-alpha-beta structure motif; other site 369723011020 NAD(p) ribose binding residues [chemical binding]; other site 369723011021 NAD binding pocket [chemical binding]; other site 369723011022 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 369723011023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 369723011024 catalytic loop [active] 369723011025 iron binding site [ion binding]; other site 369723011026 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 369723011027 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 369723011028 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 369723011029 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 369723011030 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 369723011031 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 369723011032 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 369723011033 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 369723011034 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 369723011035 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 369723011036 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 369723011037 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723011038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723011039 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723011040 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 369723011041 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 369723011042 Walker A/P-loop; other site 369723011043 ATP binding site [chemical binding]; other site 369723011044 Q-loop/lid; other site 369723011045 ABC transporter signature motif; other site 369723011046 Walker B; other site 369723011047 D-loop; other site 369723011048 H-loop/switch region; other site 369723011049 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 369723011050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 369723011051 ABC-ATPase subunit interface; other site 369723011052 dimer interface [polypeptide binding]; other site 369723011053 putative PBP binding regions; other site 369723011054 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 369723011055 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 369723011056 putative binding site residues; other site 369723011057 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 369723011058 putative active site [active] 369723011059 Zn binding site [ion binding]; other site 369723011060 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 369723011061 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 369723011062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723011063 FeS/SAM binding site; other site 369723011064 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 369723011065 NlpC/P60 family; Region: NLPC_P60; pfam00877 369723011066 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 369723011067 DEAD-like helicases superfamily; Region: DEXDc; smart00487 369723011068 ATP binding site [chemical binding]; other site 369723011069 Mg++ binding site [ion binding]; other site 369723011070 motif III; other site 369723011071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723011072 nucleotide binding region [chemical binding]; other site 369723011073 ATP-binding site [chemical binding]; other site 369723011074 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 369723011075 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 369723011076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723011077 catalytic residue [active] 369723011078 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723011079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 369723011080 putative DNA binding site [nucleotide binding]; other site 369723011081 putative Zn2+ binding site [ion binding]; other site 369723011082 AsnC family; Region: AsnC_trans_reg; pfam01037 369723011083 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 369723011084 DNA binding residues [nucleotide binding] 369723011085 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 369723011086 Flavoprotein; Region: Flavoprotein; cl08021 369723011087 prenyltransferase; Reviewed; Region: ubiA; PRK12888 369723011088 UbiA prenyltransferase family; Region: UbiA; pfam01040 369723011089 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 369723011090 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 369723011091 ResB-like family; Region: ResB; pfam05140 369723011092 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 369723011093 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 369723011094 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 369723011095 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 369723011096 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 369723011097 catalytic residues [active] 369723011098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 369723011099 catalytic core [active] 369723011100 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 369723011101 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 369723011102 inhibitor-cofactor binding pocket; inhibition site 369723011103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723011104 catalytic residue [active] 369723011105 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 369723011106 anti sigma factor interaction site; other site 369723011107 regulatory phosphorylation site [posttranslational modification]; other site 369723011108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723011109 Response regulator receiver domain; Region: Response_reg; pfam00072 369723011110 active site 369723011111 phosphorylation site [posttranslational modification] 369723011112 intermolecular recognition site; other site 369723011113 dimerization interface [polypeptide binding]; other site 369723011114 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 369723011115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723011116 dimerization interface [polypeptide binding]; other site 369723011117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723011118 dimerization interface [polypeptide binding]; other site 369723011119 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723011120 dimerization interface [polypeptide binding]; other site 369723011121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 369723011122 dimerization interface [polypeptide binding]; other site 369723011123 GAF domain; Region: GAF_2; pfam13185 369723011124 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 369723011125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723011126 ATP binding site [chemical binding]; other site 369723011127 Mg2+ binding site [ion binding]; other site 369723011128 G-X-G motif; other site 369723011129 Response regulator receiver domain; Region: Response_reg; pfam00072 369723011130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723011131 active site 369723011132 phosphorylation site [posttranslational modification] 369723011133 intermolecular recognition site; other site 369723011134 dimerization interface [polypeptide binding]; other site 369723011135 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 369723011136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 369723011137 GAF domain; Region: GAF_3; pfam13492 369723011138 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 369723011139 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 369723011140 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 369723011141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723011142 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 369723011143 hypothetical protein; Provisional; Region: PRK06815 369723011144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723011145 catalytic residue [active] 369723011146 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 369723011147 Transcriptional regulators [Transcription]; Region: FadR; COG2186 369723011148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723011149 DNA-binding site [nucleotide binding]; DNA binding site 369723011150 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 369723011151 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 369723011152 active site 369723011153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723011154 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 369723011155 FAD binding domain; Region: FAD_binding_4; pfam01565 369723011156 Berberine and berberine like; Region: BBE; pfam08031 369723011157 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 369723011158 substrate binding site [chemical binding]; other site 369723011159 Methyltransferase domain; Region: Methyltransf_23; pfam13489 369723011160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723011161 S-adenosylmethionine binding site [chemical binding]; other site 369723011162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723011163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723011164 non-specific DNA binding site [nucleotide binding]; other site 369723011165 salt bridge; other site 369723011166 sequence-specific DNA binding site [nucleotide binding]; other site 369723011167 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 369723011168 active site 369723011169 catalytic residues [active] 369723011170 metal binding site [ion binding]; metal-binding site 369723011171 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 369723011172 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 369723011173 heme-binding site [chemical binding]; other site 369723011174 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 369723011175 FAD binding pocket [chemical binding]; other site 369723011176 FAD binding motif [chemical binding]; other site 369723011177 phosphate binding motif [ion binding]; other site 369723011178 beta-alpha-beta structure motif; other site 369723011179 NAD binding pocket [chemical binding]; other site 369723011180 CAAX protease self-immunity; Region: Abi; pfam02517 369723011181 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 369723011182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723011183 non-specific DNA binding site [nucleotide binding]; other site 369723011184 salt bridge; other site 369723011185 sequence-specific DNA binding site [nucleotide binding]; other site 369723011186 Winged helix-turn helix; Region: HTH_29; pfam13551 369723011187 Homeodomain-like domain; Region: HTH_32; pfam13565 369723011188 DDE superfamily endonuclease; Region: DDE_3; pfam13358 369723011189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 369723011190 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 369723011191 Immunity protein Imm1; Region: Imm1; pfam14430 369723011192 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 369723011193 RNA binding site [nucleotide binding]; other site 369723011194 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 369723011195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 369723011196 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 369723011197 Walker A/P-loop; other site 369723011198 ATP binding site [chemical binding]; other site 369723011199 Q-loop/lid; other site 369723011200 ABC transporter signature motif; other site 369723011201 Walker B; other site 369723011202 D-loop; other site 369723011203 H-loop/switch region; other site 369723011204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 369723011205 Histidine kinase; Region: HisKA_3; pfam07730 369723011206 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 369723011207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723011208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723011209 active site 369723011210 phosphorylation site [posttranslational modification] 369723011211 intermolecular recognition site; other site 369723011212 dimerization interface [polypeptide binding]; other site 369723011213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 369723011214 DNA binding residues [nucleotide binding] 369723011215 dimerization interface [polypeptide binding]; other site 369723011216 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 369723011217 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 369723011218 Predicted transcriptional regulator [Transcription]; Region: COG2378 369723011219 HTH domain; Region: HTH_11; pfam08279 369723011220 WYL domain; Region: WYL; pfam13280 369723011221 short chain dehydrogenase; Provisional; Region: PRK08303 369723011222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723011223 NAD(P) binding site [chemical binding]; other site 369723011224 active site 369723011225 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 369723011226 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 369723011227 catalytic residues [active] 369723011228 catalytic nucleophile [active] 369723011229 Presynaptic Site I dimer interface [polypeptide binding]; other site 369723011230 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 369723011231 Synaptic Flat tetramer interface [polypeptide binding]; other site 369723011232 Synaptic Site I dimer interface [polypeptide binding]; other site 369723011233 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 369723011234 DNA-binding interface [nucleotide binding]; DNA binding site 369723011235 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 369723011236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 369723011237 Transposase; Region: DDE_Tnp_ISL3; pfam01610 369723011238 Transposase; Region: DDE_Tnp_ISL3; pfam01610 369723011239 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 369723011240 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 369723011241 putative active site [active] 369723011242 putative NTP binding site [chemical binding]; other site 369723011243 putative nucleic acid binding site [nucleotide binding]; other site 369723011244 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 369723011245 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 369723011246 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 369723011247 Integrase core domain; Region: rve; pfam00665 369723011248 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 369723011249 phosphoenolpyruvate synthase; Validated; Region: PRK06241 369723011250 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 369723011251 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 369723011252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723011253 AMP-binding enzyme; Region: AMP-binding; pfam00501 369723011254 acyl-activating enzyme (AAE) consensus motif; other site 369723011255 AMP binding site [chemical binding]; other site 369723011256 active site 369723011257 CoA binding site [chemical binding]; other site 369723011258 Phosphopantetheine attachment site; Region: PP-binding; cl09936 369723011259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723011260 NAD(P) binding site [chemical binding]; other site 369723011261 active site 369723011262 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 369723011263 active site 369723011264 prenyltransferase; Provisional; Region: ubiA; PRK13592 369723011265 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 369723011266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 369723011267 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 369723011268 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 369723011269 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 369723011270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723011271 non-specific DNA binding site [nucleotide binding]; other site 369723011272 salt bridge; other site 369723011273 sequence-specific DNA binding site [nucleotide binding]; other site 369723011274 Cupin domain; Region: Cupin_2; pfam07883 369723011275 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 369723011276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 369723011277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 369723011278 catalytic nucleophile [active] 369723011279 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 369723011280 catalytic residue [active] 369723011281 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 369723011282 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 369723011283 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 369723011284 IHF - DNA interface [nucleotide binding]; other site 369723011285 IHF dimer interface [polypeptide binding]; other site 369723011286 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 369723011287 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 369723011288 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 369723011289 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723011290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723011291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 369723011292 active site 369723011293 dimerization interface [polypeptide binding]; other site 369723011294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 369723011295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 369723011296 active site 369723011297 phosphorylation site [posttranslational modification] 369723011298 intermolecular recognition site; other site 369723011299 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 369723011300 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 369723011301 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 369723011302 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723011303 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723011304 Walker A/P-loop; other site 369723011305 ATP binding site [chemical binding]; other site 369723011306 Q-loop/lid; other site 369723011307 ABC transporter signature motif; other site 369723011308 Walker B; other site 369723011309 D-loop; other site 369723011310 H-loop/switch region; other site 369723011311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723011312 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 369723011313 Walker A/P-loop; other site 369723011314 ATP binding site [chemical binding]; other site 369723011315 Q-loop/lid; other site 369723011316 ABC transporter signature motif; other site 369723011317 Walker B; other site 369723011318 D-loop; other site 369723011319 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 369723011320 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 369723011321 substrate binding site [chemical binding]; other site 369723011322 ATP binding site [chemical binding]; other site 369723011323 choline dehydrogenase; Validated; Region: PRK02106 369723011324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723011325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 369723011326 active site 369723011327 metal binding site [ion binding]; metal-binding site 369723011328 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 369723011329 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 369723011330 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 369723011331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723011332 NAD(P) binding site [chemical binding]; other site 369723011333 active site 369723011334 Histidine kinase; Region: HisKA_3; pfam07730 369723011335 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 369723011336 ATP binding site [chemical binding]; other site 369723011337 Mg2+ binding site [ion binding]; other site 369723011338 G-X-G motif; other site 369723011339 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723011340 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 369723011341 Walker A/P-loop; other site 369723011342 ATP binding site [chemical binding]; other site 369723011343 Q-loop/lid; other site 369723011344 ABC transporter signature motif; other site 369723011345 Walker B; other site 369723011346 D-loop; other site 369723011347 H-loop/switch region; other site 369723011348 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 369723011349 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 369723011350 FtsX-like permease family; Region: FtsX; pfam02687 369723011351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723011352 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 369723011353 Fructosamine kinase; Region: Fructosamin_kin; cl17579 369723011354 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 369723011355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723011356 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 369723011357 intracellular protease, PfpI family; Region: PfpI; TIGR01382 369723011358 proposed catalytic triad [active] 369723011359 conserved cys residue [active] 369723011360 GTPase RsgA; Reviewed; Region: PRK01889 369723011361 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 369723011362 GTPase/Zn-binding domain interface [polypeptide binding]; other site 369723011363 GTP/Mg2+ binding site [chemical binding]; other site 369723011364 G4 box; other site 369723011365 G5 box; other site 369723011366 G1 box; other site 369723011367 Switch I region; other site 369723011368 G2 box; other site 369723011369 G3 box; other site 369723011370 Switch II region; other site 369723011371 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723011372 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 369723011373 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 369723011374 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 369723011375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723011376 Coenzyme A binding pocket [chemical binding]; other site 369723011377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 369723011378 DEAD-like helicases superfamily; Region: DEXDc; smart00487 369723011379 ATP binding site [chemical binding]; other site 369723011380 putative Mg++ binding site [ion binding]; other site 369723011381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 369723011382 nucleotide binding region [chemical binding]; other site 369723011383 ATP-binding site [chemical binding]; other site 369723011384 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 369723011385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723011386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723011387 DNA binding residues [nucleotide binding] 369723011388 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 369723011389 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 369723011390 active site 369723011391 putative catalytic site [active] 369723011392 BioY family; Region: BioY; pfam02632 369723011393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723011394 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 369723011395 Domain of unknown function (DUF385); Region: DUF385; pfam04075 369723011396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 369723011397 MOSC domain; Region: MOSC; pfam03473 369723011398 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 369723011399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723011400 Coenzyme A binding pocket [chemical binding]; other site 369723011401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 369723011402 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 369723011403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723011404 motif II; other site 369723011405 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 369723011406 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 369723011407 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 369723011408 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 369723011409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723011410 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 369723011411 DNA binding residues [nucleotide binding] 369723011412 YCII-related domain; Region: YCII; cl00999 369723011413 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 369723011414 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 369723011415 Walker A/P-loop; other site 369723011416 ATP binding site [chemical binding]; other site 369723011417 Q-loop/lid; other site 369723011418 ABC transporter signature motif; other site 369723011419 Walker B; other site 369723011420 D-loop; other site 369723011421 H-loop/switch region; other site 369723011422 TOBE domain; Region: TOBE_2; pfam08402 369723011423 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 369723011424 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 369723011425 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 369723011426 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 369723011427 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 369723011428 active site 369723011429 HIGH motif; other site 369723011430 nucleotide binding site [chemical binding]; other site 369723011431 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 369723011432 KMSKS motif; other site 369723011433 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 369723011434 Transcriptional regulator [Transcription]; Region: IclR; COG1414 369723011435 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 369723011436 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 369723011437 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 369723011438 active site 369723011439 catalytic residues [active] 369723011440 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 369723011441 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 369723011442 EamA-like transporter family; Region: EamA; pfam00892 369723011443 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 369723011444 CGNR zinc finger; Region: zf-CGNR; pfam11706 369723011445 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 369723011446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723011447 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 369723011448 Uncharacterized conserved protein [Function unknown]; Region: COG0398 369723011449 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 369723011450 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723011451 hypothetical protein; Provisional; Region: PRK11622 369723011452 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 369723011453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 369723011454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011455 ABC-ATPase subunit interface; other site 369723011456 putative PBP binding loops; other site 369723011457 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 369723011458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011459 ABC-ATPase subunit interface; other site 369723011460 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 369723011461 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 369723011462 Walker A/P-loop; other site 369723011463 ATP binding site [chemical binding]; other site 369723011464 Q-loop/lid; other site 369723011465 ABC transporter signature motif; other site 369723011466 Walker B; other site 369723011467 D-loop; other site 369723011468 H-loop/switch region; other site 369723011469 TOBE domain; Region: TOBE_2; pfam08402 369723011470 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723011471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723011472 sequence-specific DNA binding site [nucleotide binding]; other site 369723011473 salt bridge; other site 369723011474 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 369723011475 RibD C-terminal domain; Region: RibD_C; cl17279 369723011476 Uncharacterized conserved protein [Function unknown]; Region: COG1359 369723011477 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 369723011478 homotrimer interaction site [polypeptide binding]; other site 369723011479 putative active site [active] 369723011480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723011481 WHG domain; Region: WHG; pfam13305 369723011482 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 369723011483 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 369723011484 fumarate hydratase; Reviewed; Region: fumC; PRK00485 369723011485 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 369723011486 active sites [active] 369723011487 tetramer interface [polypeptide binding]; other site 369723011488 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 369723011489 DNA binding site [nucleotide binding] 369723011490 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 369723011491 AAA domain; Region: AAA_22; pfam13401 369723011492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 369723011493 TPR motif; other site 369723011494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 369723011495 binding surface 369723011496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 369723011497 fumarate hydratase; Provisional; Region: PRK15389 369723011498 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 369723011499 Fumarase C-terminus; Region: Fumerase_C; pfam05683 369723011500 PQQ-like domain; Region: PQQ_2; pfam13360 369723011501 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723011502 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723011503 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 369723011504 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 369723011505 AsnC family; Region: AsnC_trans_reg; pfam01037 369723011506 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 369723011507 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 369723011508 dimer interface [polypeptide binding]; other site 369723011509 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 369723011510 active site 369723011511 Fe binding site [ion binding]; other site 369723011512 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 369723011513 RDD family; Region: RDD; pfam06271 369723011514 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 369723011515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723011516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723011517 homodimer interface [polypeptide binding]; other site 369723011518 catalytic residue [active] 369723011519 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 369723011520 PQQ-like domain; Region: PQQ_2; pfam13360 369723011521 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 369723011522 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723011523 fumarylacetoacetase; Region: PLN02856 369723011524 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 369723011525 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 369723011526 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 369723011527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 369723011528 binding surface 369723011529 TPR motif; other site 369723011530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 369723011531 binding surface 369723011532 TPR motif; other site 369723011533 TPR repeat; Region: TPR_11; pfam13414 369723011534 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 369723011535 homotrimer interaction site [polypeptide binding]; other site 369723011536 zinc binding site [ion binding]; other site 369723011537 CDP-binding sites; other site 369723011538 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 369723011539 dimer interface; other site 369723011540 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 369723011541 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 369723011542 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 369723011543 active site 369723011544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723011545 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723011546 active site 369723011547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723011548 S-adenosylmethionine binding site [chemical binding]; other site 369723011549 DNA repair protein RadA; Provisional; Region: PRK11823 369723011550 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 369723011551 Walker A motif; other site 369723011552 ATP binding site [chemical binding]; other site 369723011553 Walker B motif; other site 369723011554 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 369723011555 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 369723011556 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 369723011557 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 369723011558 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 369723011559 active site 369723011560 catalytic residues [active] 369723011561 metal binding site [ion binding]; metal-binding site 369723011562 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 369723011563 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 369723011564 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 369723011565 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 369723011566 minor groove reading motif; other site 369723011567 helix-hairpin-helix signature motif; other site 369723011568 active site 369723011569 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 369723011570 Clp protease ATP binding subunit; Region: clpC; CHL00095 369723011571 Clp amino terminal domain; Region: Clp_N; pfam02861 369723011572 Clp amino terminal domain; Region: Clp_N; pfam02861 369723011573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723011574 Walker A motif; other site 369723011575 ATP binding site [chemical binding]; other site 369723011576 Walker B motif; other site 369723011577 arginine finger; other site 369723011578 UvrB/uvrC motif; Region: UVR; pfam02151 369723011579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723011580 Walker A motif; other site 369723011581 ATP binding site [chemical binding]; other site 369723011582 Walker B motif; other site 369723011583 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 369723011584 Lsr2; Region: Lsr2; pfam11774 369723011585 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 369723011586 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 369723011587 dimer interface [polypeptide binding]; other site 369723011588 putative anticodon binding site; other site 369723011589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 369723011590 motif 1; other site 369723011591 dimer interface [polypeptide binding]; other site 369723011592 active site 369723011593 motif 2; other site 369723011594 motif 3; other site 369723011595 pantothenate kinase; Reviewed; Region: PRK13318 369723011596 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 369723011597 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 369723011598 active site 369723011599 L-aspartate oxidase; Provisional; Region: PRK07804 369723011600 L-aspartate oxidase; Provisional; Region: PRK06175 369723011601 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 369723011602 Septum formation; Region: Septum_form; pfam13845 369723011603 Septum formation; Region: Septum_form; pfam13845 369723011604 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 369723011605 tetramerization interface [polypeptide binding]; other site 369723011606 active site 369723011607 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 369723011608 pantoate--beta-alanine ligase; Region: panC; TIGR00018 369723011609 active site 369723011610 nucleotide binding site [chemical binding]; other site 369723011611 HIGH motif; other site 369723011612 KMSKS motif; other site 369723011613 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 369723011614 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 369723011615 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 369723011616 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 369723011617 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 369723011618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011619 ABC-ATPase subunit interface; other site 369723011620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011621 ABC-ATPase subunit interface; other site 369723011622 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 369723011623 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 369723011624 Walker A/P-loop; other site 369723011625 ATP binding site [chemical binding]; other site 369723011626 Q-loop/lid; other site 369723011627 ABC transporter signature motif; other site 369723011628 Walker B; other site 369723011629 D-loop; other site 369723011630 H-loop/switch region; other site 369723011631 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 369723011632 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 369723011633 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 369723011634 catalytic center binding site [active] 369723011635 ATP binding site [chemical binding]; other site 369723011636 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 369723011637 homooctamer interface [polypeptide binding]; other site 369723011638 active site 369723011639 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 369723011640 dihydropteroate synthase; Region: DHPS; TIGR01496 369723011641 substrate binding pocket [chemical binding]; other site 369723011642 dimer interface [polypeptide binding]; other site 369723011643 inhibitor binding site; inhibition site 369723011644 AAA-like domain; Region: AAA_10; pfam12846 369723011645 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14654 369723011646 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 369723011647 Peptidase family M23; Region: Peptidase_M23; pfam01551 369723011648 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 369723011649 homodecamer interface [polypeptide binding]; other site 369723011650 GTP cyclohydrolase I; Provisional; Region: PLN03044 369723011651 active site 369723011652 putative catalytic site residues [active] 369723011653 zinc binding site [ion binding]; other site 369723011654 GTP-CH-I/GFRP interaction surface; other site 369723011655 FtsH Extracellular; Region: FtsH_ext; pfam06480 369723011656 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 369723011657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 369723011658 Walker A motif; other site 369723011659 ATP binding site [chemical binding]; other site 369723011660 Walker B motif; other site 369723011661 arginine finger; other site 369723011662 Peptidase family M41; Region: Peptidase_M41; pfam01434 369723011663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723011664 active site 369723011665 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 369723011666 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 369723011667 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 369723011668 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 369723011669 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 369723011670 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 369723011671 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 369723011672 dimer interface [polypeptide binding]; other site 369723011673 substrate binding site [chemical binding]; other site 369723011674 metal binding sites [ion binding]; metal-binding site 369723011675 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 369723011676 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 369723011677 active site 369723011678 catalytic residues [active] 369723011679 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 369723011680 active site 369723011681 Colicin V production protein; Region: Colicin_V; pfam02674 369723011682 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 369723011683 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 369723011684 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 369723011685 putative active site [active] 369723011686 putative CoA binding site [chemical binding]; other site 369723011687 nudix motif; other site 369723011688 metal binding site [ion binding]; metal-binding site 369723011689 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 369723011690 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723011691 catalytic residues [active] 369723011692 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 369723011693 endonuclease III; Region: ENDO3c; smart00478 369723011694 minor groove reading motif; other site 369723011695 helix-hairpin-helix signature motif; other site 369723011696 substrate binding pocket [chemical binding]; other site 369723011697 active site 369723011698 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 369723011699 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 369723011700 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 369723011701 putative active site [active] 369723011702 putative metal binding site [ion binding]; other site 369723011703 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 369723011704 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 369723011705 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 369723011706 ligand binding site [chemical binding]; other site 369723011707 flexible hinge region; other site 369723011708 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 369723011709 putative switch regulator; other site 369723011710 non-specific DNA interactions [nucleotide binding]; other site 369723011711 DNA binding site [nucleotide binding] 369723011712 sequence specific DNA binding site [nucleotide binding]; other site 369723011713 putative cAMP binding site [chemical binding]; other site 369723011714 TIGR03084 family protein; Region: TIGR03084 369723011715 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 369723011716 Wyosine base formation; Region: Wyosine_form; pfam08608 369723011717 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 369723011718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723011719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 369723011720 active site 369723011721 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 369723011722 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 369723011723 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 369723011724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 369723011725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723011726 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 369723011727 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 369723011728 carboxyltransferase (CT) interaction site; other site 369723011729 biotinylation site [posttranslational modification]; other site 369723011730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 369723011731 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 369723011732 active site 369723011733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 369723011734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 369723011735 DNA-binding site [nucleotide binding]; DNA binding site 369723011736 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 369723011737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723011738 nucleotide binding site [chemical binding]; other site 369723011739 Uncharacterized conserved protein [Function unknown]; Region: COG5476 369723011740 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 369723011741 MlrC C-terminus; Region: MlrC_C; pfam07171 369723011742 Penicillinase repressor; Region: Pencillinase_R; cl17580 369723011743 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 369723011744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 369723011745 nucleotide binding site [chemical binding]; other site 369723011746 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 369723011747 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 369723011748 peptide binding site [polypeptide binding]; other site 369723011749 dimer interface [polypeptide binding]; other site 369723011750 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 369723011751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011752 dimer interface [polypeptide binding]; other site 369723011753 conserved gate region; other site 369723011754 putative PBP binding loops; other site 369723011755 ABC-ATPase subunit interface; other site 369723011756 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 369723011757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 369723011758 dimer interface [polypeptide binding]; other site 369723011759 conserved gate region; other site 369723011760 putative PBP binding loops; other site 369723011761 ABC-ATPase subunit interface; other site 369723011762 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 369723011763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723011764 Walker A/P-loop; other site 369723011765 ATP binding site [chemical binding]; other site 369723011766 Q-loop/lid; other site 369723011767 ABC transporter signature motif; other site 369723011768 Walker B; other site 369723011769 D-loop; other site 369723011770 H-loop/switch region; other site 369723011771 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 369723011772 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 369723011773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 369723011774 Walker A/P-loop; other site 369723011775 ATP binding site [chemical binding]; other site 369723011776 Q-loop/lid; other site 369723011777 ABC transporter signature motif; other site 369723011778 Walker B; other site 369723011779 D-loop; other site 369723011780 H-loop/switch region; other site 369723011781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 369723011782 CutC family; Region: CutC; cl01218 369723011783 Predicted membrane protein [Function unknown]; Region: COG4270 369723011784 putative phosphatase; Provisional; Region: PRK11587 369723011785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723011786 active site 369723011787 motif I; other site 369723011788 motif II; other site 369723011789 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 369723011790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 369723011791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 369723011792 active site 369723011793 ATP binding site [chemical binding]; other site 369723011794 substrate binding site [chemical binding]; other site 369723011795 activation loop (A-loop); other site 369723011796 Double zinc ribbon; Region: DZR; pfam12773 369723011797 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 369723011798 cyclase homology domain; Region: CHD; cd07302 369723011799 nucleotidyl binding site; other site 369723011800 metal binding site [ion binding]; metal-binding site 369723011801 dimer interface [polypeptide binding]; other site 369723011802 AAA ATPase domain; Region: AAA_16; pfam13191 369723011803 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 369723011804 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 369723011805 homotrimer interaction site [polypeptide binding]; other site 369723011806 putative active site [active] 369723011807 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 369723011808 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 369723011809 DTAP/Switch II; other site 369723011810 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 369723011811 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 369723011812 DTAP/Switch II; other site 369723011813 Switch I; other site 369723011814 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 369723011815 Transcription factor WhiB; Region: Whib; pfam02467 369723011816 Transglycosylase; Region: Transgly; pfam00912 369723011817 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 369723011818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 369723011819 Yqey-like protein; Region: YqeY; cl17540 369723011820 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 369723011821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723011822 putative active site [active] 369723011823 putative metal binding site [ion binding]; other site 369723011824 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 369723011825 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723011826 putative catalytic residues [active] 369723011827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723011828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723011829 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 369723011830 putative active site [active] 369723011831 catalytic site [active] 369723011832 putative metal binding site [ion binding]; other site 369723011833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723011834 Q-loop/lid; other site 369723011835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723011836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723011837 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 369723011838 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 369723011839 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 369723011840 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 369723011841 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 369723011842 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 369723011843 RNA binding surface [nucleotide binding]; other site 369723011844 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 369723011845 nudix motif; other site 369723011846 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 369723011847 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 369723011848 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 369723011849 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723011850 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 369723011851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 369723011852 catalytic residue [active] 369723011853 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 369723011854 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723011855 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 369723011856 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 369723011857 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723011858 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 369723011859 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 369723011860 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723011861 DNA binding residues [nucleotide binding] 369723011862 dimer interface [polypeptide binding]; other site 369723011863 ABC-2 type transporter; Region: ABC2_membrane; cl17235 369723011864 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 369723011865 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 369723011866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723011867 Walker A/P-loop; other site 369723011868 ATP binding site [chemical binding]; other site 369723011869 Q-loop/lid; other site 369723011870 ABC transporter signature motif; other site 369723011871 Walker B; other site 369723011872 D-loop; other site 369723011873 H-loop/switch region; other site 369723011874 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 369723011875 SnoaL-like domain; Region: SnoaL_2; pfam12680 369723011876 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 369723011877 dimer interface [polypeptide binding]; other site 369723011878 putative radical transfer pathway; other site 369723011879 diiron center [ion binding]; other site 369723011880 tyrosyl radical; other site 369723011881 ATP cone domain; Region: ATP-cone; pfam03477 369723011882 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 369723011883 Class I ribonucleotide reductase; Region: RNR_I; cd01679 369723011884 active site 369723011885 dimer interface [polypeptide binding]; other site 369723011886 catalytic residues [active] 369723011887 effector binding site; other site 369723011888 R2 peptide binding site; other site 369723011889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 369723011890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723011891 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 369723011892 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 369723011893 active site 369723011894 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 369723011895 active site 369723011896 catalytic site [active] 369723011897 Zn binding site [ion binding]; other site 369723011898 tetramer interface [polypeptide binding]; other site 369723011899 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 369723011900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 369723011901 Coenzyme A binding pocket [chemical binding]; other site 369723011902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 369723011903 Beta-lactamase; Region: Beta-lactamase; pfam00144 369723011904 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723011905 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 369723011906 Walker A/P-loop; other site 369723011907 ATP binding site [chemical binding]; other site 369723011908 Q-loop/lid; other site 369723011909 ABC transporter signature motif; other site 369723011910 Walker B; other site 369723011911 D-loop; other site 369723011912 H-loop/switch region; other site 369723011913 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 369723011914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723011915 Walker A/P-loop; other site 369723011916 ATP binding site [chemical binding]; other site 369723011917 Q-loop/lid; other site 369723011918 ABC transporter signature motif; other site 369723011919 Walker B; other site 369723011920 D-loop; other site 369723011921 H-loop/switch region; other site 369723011922 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 369723011923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723011924 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 369723011925 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 369723011926 YCII-related domain; Region: YCII; cl00999 369723011927 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 369723011928 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 369723011929 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 369723011930 active site 369723011931 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 369723011932 aromatic chitin/cellulose binding site residues [chemical binding]; other site 369723011933 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 369723011934 aromatic chitin/cellulose binding site residues [chemical binding]; other site 369723011935 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 369723011936 putative sugar binding site [chemical binding]; other site 369723011937 catalytic residues [active] 369723011938 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 369723011939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723011940 putative substrate translocation pore; other site 369723011941 DDE superfamily endonuclease; Region: DDE_5; cl17874 369723011942 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 369723011943 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 369723011944 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 369723011945 tetramer interface [polypeptide binding]; other site 369723011946 active site 369723011947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723011948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 369723011949 Walker A/P-loop; other site 369723011950 ATP binding site [chemical binding]; other site 369723011951 Q-loop/lid; other site 369723011952 ABC transporter signature motif; other site 369723011953 Walker B; other site 369723011954 D-loop; other site 369723011955 H-loop/switch region; other site 369723011956 Helix-turn-helix domain; Region: HTH_31; pfam13560 369723011957 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 369723011958 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 369723011959 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 369723011960 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 369723011961 substrate binding pocket [chemical binding]; other site 369723011962 catalytic residues [active] 369723011963 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 369723011964 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 369723011965 Methyltransferase domain; Region: Methyltransf_18; pfam12847 369723011966 H+ Antiporter protein; Region: 2A0121; TIGR00900 369723011967 Condensation domain; Region: Condensation; pfam00668 369723011968 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723011969 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723011970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 369723011971 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723011972 acyl-activating enzyme (AAE) consensus motif; other site 369723011973 AMP binding site [chemical binding]; other site 369723011974 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723011975 thioester reductase domain; Region: Thioester-redct; TIGR01746 369723011976 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 369723011977 putative NAD(P) binding site [chemical binding]; other site 369723011978 active site 369723011979 putative substrate binding site [chemical binding]; other site 369723011980 Condensation domain; Region: Condensation; pfam00668 369723011981 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723011982 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723011983 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 369723011984 acyl-activating enzyme (AAE) consensus motif; other site 369723011985 AMP binding site [chemical binding]; other site 369723011986 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723011987 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 369723011988 hypothetical protein; Provisional; Region: PRK07236 369723011989 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 369723011990 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 369723011991 acyl-activating enzyme (AAE) consensus motif; other site 369723011992 AMP binding site [chemical binding]; other site 369723011993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723011994 Condensation domain; Region: Condensation; pfam00668 369723011995 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 369723011996 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 369723011997 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 369723011998 acyl-activating enzyme (AAE) consensus motif; other site 369723011999 AMP binding site [chemical binding]; other site 369723012000 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 369723012001 MbtH-like protein; Region: MbtH; cl01279 369723012002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723012003 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 369723012004 Walker A/P-loop; other site 369723012005 ATP binding site [chemical binding]; other site 369723012006 Q-loop/lid; other site 369723012007 ABC transporter signature motif; other site 369723012008 Walker B; other site 369723012009 D-loop; other site 369723012010 H-loop/switch region; other site 369723012011 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 369723012012 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 369723012013 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 369723012014 putative sugar binding sites [chemical binding]; other site 369723012015 Q-X-W motif; other site 369723012016 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 369723012017 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 369723012018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 369723012019 Cytochrome P450; Region: p450; cl12078 369723012020 RNHCP domain; Region: RNHCP; pfam12647 369723012021 RNHCP domain; Region: RNHCP; pfam12647 369723012022 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 369723012023 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 369723012024 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 369723012025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 369723012026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 369723012027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 369723012028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 369723012029 putative metal binding site [ion binding]; other site 369723012030 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 369723012031 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 369723012032 DNA binding residues [nucleotide binding] 369723012033 B12 binding domain; Region: B12-binding_2; cl03653 369723012034 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 369723012035 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 369723012036 active site 369723012037 metal binding site [ion binding]; metal-binding site 369723012038 nudix motif; other site 369723012039 phytoene desaturase; Region: crtI_fam; TIGR02734 369723012040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723012041 hydroxyglutarate oxidase; Provisional; Region: PRK11728 369723012042 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 369723012043 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 369723012044 substrate binding pocket [chemical binding]; other site 369723012045 chain length determination region; other site 369723012046 substrate-Mg2+ binding site; other site 369723012047 catalytic residues [active] 369723012048 aspartate-rich region 1; other site 369723012049 active site lid residues [active] 369723012050 aspartate-rich region 2; other site 369723012051 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 369723012052 active site lid residues [active] 369723012053 substrate binding pocket [chemical binding]; other site 369723012054 catalytic residues [active] 369723012055 substrate-Mg2+ binding site; other site 369723012056 aspartate-rich region 1; other site 369723012057 aspartate-rich region 2; other site 369723012058 mercuric reductase; Validated; Region: PRK06370 369723012059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723012060 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 369723012061 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 369723012062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723012063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 369723012064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723012065 Walker A/P-loop; other site 369723012066 ATP binding site [chemical binding]; other site 369723012067 Q-loop/lid; other site 369723012068 ABC transporter signature motif; other site 369723012069 Walker B; other site 369723012070 D-loop; other site 369723012071 H-loop/switch region; other site 369723012072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 369723012073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 369723012074 Walker A/P-loop; other site 369723012075 ATP binding site [chemical binding]; other site 369723012076 Q-loop/lid; other site 369723012077 ABC transporter signature motif; other site 369723012078 Walker B; other site 369723012079 D-loop; other site 369723012080 H-loop/switch region; other site 369723012081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 369723012082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 369723012083 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 369723012084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 369723012085 substrate binding site [chemical binding]; other site 369723012086 oxyanion hole (OAH) forming residues; other site 369723012087 trimer interface [polypeptide binding]; other site 369723012088 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 369723012089 putative FMN binding site [chemical binding]; other site 369723012090 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 369723012091 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 369723012092 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 369723012093 MOSC domain; Region: MOSC; pfam03473 369723012094 TadE-like protein; Region: TadE; pfam07811 369723012095 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 369723012096 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 369723012097 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 369723012098 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 369723012099 Walker A motif; other site 369723012100 ATP binding site [chemical binding]; other site 369723012101 Walker B motif; other site 369723012102 AAA domain; Region: AAA_31; pfam13614 369723012103 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 369723012104 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723012105 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 369723012106 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723012107 Helix-turn-helix domain; Region: HTH_18; pfam12833 369723012108 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 369723012109 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 369723012110 NAD(P) binding site [chemical binding]; other site 369723012111 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 369723012112 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 369723012113 DNA binding residues [nucleotide binding] 369723012114 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 369723012115 TPP-binding site [chemical binding]; other site 369723012116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 369723012117 PYR/PP interface [polypeptide binding]; other site 369723012118 dimer interface [polypeptide binding]; other site 369723012119 TPP binding site [chemical binding]; other site 369723012120 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 369723012121 Ligand binding site; other site 369723012122 Putative Catalytic site; other site 369723012123 DXD motif; other site 369723012124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 369723012125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723012126 dimer interface [polypeptide binding]; other site 369723012127 phosphorylation site [posttranslational modification] 369723012128 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 369723012129 Mg2+ binding site [ion binding]; other site 369723012130 G-X-G motif; other site 369723012131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 369723012132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723012133 active site 369723012134 phosphorylation site [posttranslational modification] 369723012135 intermolecular recognition site; other site 369723012136 dimerization interface [polypeptide binding]; other site 369723012137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 369723012138 DNA binding site [nucleotide binding] 369723012139 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 369723012140 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 369723012141 dimer interface [polypeptide binding]; other site 369723012142 active site 369723012143 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 369723012144 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 369723012145 Rhomboid family; Region: Rhomboid; pfam01694 369723012146 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 369723012147 active site 369723012148 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 369723012149 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 369723012150 oligomer interface [polypeptide binding]; other site 369723012151 metal binding site [ion binding]; metal-binding site 369723012152 metal binding site [ion binding]; metal-binding site 369723012153 putative Cl binding site [ion binding]; other site 369723012154 basic sphincter; other site 369723012155 hydrophobic gate; other site 369723012156 periplasmic entrance; other site 369723012157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723012158 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 369723012159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723012160 homodimer interface [polypeptide binding]; other site 369723012161 catalytic residue [active] 369723012162 FOG: CBS domain [General function prediction only]; Region: COG0517 369723012163 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 369723012164 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 369723012165 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 369723012166 active site 369723012167 metal-binding site 369723012168 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 369723012169 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 369723012170 active site 369723012171 metal binding site [ion binding]; metal-binding site 369723012172 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 369723012173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 369723012174 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 369723012175 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 369723012176 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 369723012177 putative DNA binding site [nucleotide binding]; other site 369723012178 catalytic residue [active] 369723012179 putative H2TH interface [polypeptide binding]; other site 369723012180 putative catalytic residues [active] 369723012181 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 369723012182 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 369723012183 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 369723012184 Bacterial sugar transferase; Region: Bac_transf; pfam02397 369723012185 Histidine kinase; Region: His_kinase; pfam06580 369723012186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723012187 ATP binding site [chemical binding]; other site 369723012188 Mg2+ binding site [ion binding]; other site 369723012189 G-X-G motif; other site 369723012190 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 369723012191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 369723012192 active site 369723012193 phosphorylation site [posttranslational modification] 369723012194 intermolecular recognition site; other site 369723012195 dimerization interface [polypeptide binding]; other site 369723012196 LytTr DNA-binding domain; Region: LytTR; smart00850 369723012197 Protein of unknown function, DUF485; Region: DUF485; pfam04341 369723012198 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 369723012199 Na binding site [ion binding]; other site 369723012200 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 369723012201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723012202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 369723012203 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 369723012204 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 369723012205 Walker A/P-loop; other site 369723012206 ATP binding site [chemical binding]; other site 369723012207 Q-loop/lid; other site 369723012208 ABC transporter signature motif; other site 369723012209 Walker B; other site 369723012210 D-loop; other site 369723012211 H-loop/switch region; other site 369723012212 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 369723012213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723012214 DNA binding residues [nucleotide binding] 369723012215 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723012216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723012217 sequence-specific DNA binding site [nucleotide binding]; other site 369723012218 salt bridge; other site 369723012219 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 369723012220 Protein of unknown function, DUF485; Region: DUF485; pfam04341 369723012221 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 369723012222 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 369723012223 Na binding site [ion binding]; other site 369723012224 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 369723012225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 369723012226 NAD(P) binding site [chemical binding]; other site 369723012227 active site 369723012228 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 369723012229 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 369723012230 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 369723012231 active site residue [active] 369723012232 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 369723012233 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 369723012234 active site 369723012235 catalytic site [active] 369723012236 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 369723012237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 369723012238 putative active site [active] 369723012239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 369723012240 dimer interface [polypeptide binding]; other site 369723012241 phosphorylation site [posttranslational modification] 369723012242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 369723012243 ATP binding site [chemical binding]; other site 369723012244 Mg2+ binding site [ion binding]; other site 369723012245 G-X-G motif; other site 369723012246 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 369723012247 arginine deiminase; Provisional; Region: PRK01388 369723012248 Uncharacterized conserved protein [Function unknown]; Region: COG3603 369723012249 Family description; Region: ACT_7; pfam13840 369723012250 prephenate dehydratase; Provisional; Region: PRK11898 369723012251 Prephenate dehydratase; Region: PDT; pfam00800 369723012252 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 369723012253 putative L-Phe binding site [chemical binding]; other site 369723012254 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 369723012255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723012256 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 369723012257 active site 369723012258 motif I; other site 369723012259 motif II; other site 369723012260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 369723012261 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 369723012262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 369723012263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 369723012264 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 369723012265 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 369723012266 putative ligand binding site [chemical binding]; other site 369723012267 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 369723012268 Amidinotransferase; Region: Amidinotransf; pfam02274 369723012269 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 369723012270 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 369723012271 putative DNA binding site [nucleotide binding]; other site 369723012272 putative Zn2+ binding site [ion binding]; other site 369723012273 AsnC family; Region: AsnC_trans_reg; pfam01037 369723012274 Beta propeller domain; Region: Beta_propel; pfam09826 369723012275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 369723012276 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 369723012277 Fructosamine kinase; Region: Fructosamin_kin; cl17579 369723012278 Phosphotransferase enzyme family; Region: APH; pfam01636 369723012279 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 369723012280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 369723012281 FeS/SAM binding site; other site 369723012282 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 369723012283 Ubiquitin-like proteins; Region: UBQ; cl00155 369723012284 charged pocket; other site 369723012285 hydrophobic patch; other site 369723012286 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 369723012287 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 369723012288 putative active site [active] 369723012289 putative metal binding site [ion binding]; other site 369723012290 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 369723012291 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 369723012292 Part of AAA domain; Region: AAA_19; pfam13245 369723012293 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 369723012294 Family description; Region: UvrD_C_2; pfam13538 369723012295 AAA ATPase domain; Region: AAA_16; pfam13191 369723012296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 369723012297 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 369723012298 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 369723012299 MoaE homodimer interface [polypeptide binding]; other site 369723012300 MoaD interaction [polypeptide binding]; other site 369723012301 active site residues [active] 369723012302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 369723012303 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 369723012304 dimer interface [polypeptide binding]; other site 369723012305 putative functional site; other site 369723012306 putative MPT binding site; other site 369723012307 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 369723012308 MPT binding site; other site 369723012309 trimer interface [polypeptide binding]; other site 369723012310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 369723012311 active site 369723012312 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 369723012313 replicative DNA helicase; Region: DnaB; TIGR00665 369723012314 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 369723012315 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 369723012316 Walker A motif; other site 369723012317 ATP binding site [chemical binding]; other site 369723012318 Walker B motif; other site 369723012319 DNA binding loops [nucleotide binding] 369723012320 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 369723012321 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 369723012322 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 369723012323 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 369723012324 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 369723012325 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 369723012326 dimer interface [polypeptide binding]; other site 369723012327 ssDNA binding site [nucleotide binding]; other site 369723012328 tetramer (dimer of dimers) interface [polypeptide binding]; other site 369723012329 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 369723012330 endonuclease IV; Provisional; Region: PRK01060 369723012331 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 369723012332 AP (apurinic/apyrimidinic) site pocket; other site 369723012333 DNA interaction; other site 369723012334 Metal-binding active site; metal-binding site 369723012335 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 369723012336 Predicted integral membrane protein [Function unknown]; Region: COG5650 369723012337 Transglycosylase; Region: Transgly; pfam00912 369723012338 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 369723012339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 369723012340 Predicted transcriptional regulators [Transcription]; Region: COG1695 369723012341 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 369723012342 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 369723012343 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 369723012344 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012345 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012346 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012349 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 369723012350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 369723012351 salt bridge; other site 369723012352 non-specific DNA binding site [nucleotide binding]; other site 369723012353 sequence-specific DNA binding site [nucleotide binding]; other site 369723012354 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723012355 Domain of unknown function (DUF397); Region: DUF397; pfam04149 369723012356 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 369723012357 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 369723012358 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 369723012359 DNA binding site [nucleotide binding] 369723012360 active site 369723012361 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 369723012362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723012363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 369723012364 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 369723012365 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 369723012366 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 369723012367 active site 369723012368 NTP binding site [chemical binding]; other site 369723012369 metal binding triad [ion binding]; metal-binding site 369723012370 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 369723012371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 369723012372 Zn2+ binding site [ion binding]; other site 369723012373 Mg2+ binding site [ion binding]; other site 369723012374 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 369723012375 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 369723012376 active site 369723012377 ATP binding site [chemical binding]; other site 369723012378 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 369723012379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 369723012380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 369723012381 DNA binding residues [nucleotide binding] 369723012382 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 369723012383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 369723012384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 369723012385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 369723012386 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 369723012387 catalytic residues [active] 369723012388 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 369723012389 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 369723012390 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 369723012391 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 369723012392 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 369723012393 active site 369723012394 metal binding site [ion binding]; metal-binding site 369723012395 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 369723012396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 369723012397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 369723012398 homodimer interface [polypeptide binding]; other site 369723012399 catalytic residue [active] 369723012400 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 369723012401 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 369723012402 ATP-grasp domain; Region: ATP-grasp_4; cl17255 369723012403 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 369723012404 ParB-like nuclease domain; Region: ParBc; pfam02195 369723012405 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 369723012406 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 369723012407 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 369723012408 Magnesium ion binding site [ion binding]; other site 369723012409 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 369723012410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 369723012411 S-adenosylmethionine binding site [chemical binding]; other site 369723012412 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 369723012413 G-X-X-G motif; other site 369723012414 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 369723012415 RxxxH motif; other site 369723012416 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 369723012417 Haemolytic domain; Region: Haemolytic; pfam01809 369723012418 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399