-- dump date 20140620_042955 -- class Genbank::misc_feature -- table misc_feature_note -- id note 218493000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 218493000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 218493000004 putative catalytic residues [active] 218493000005 putative nucleotide binding site [chemical binding]; other site 218493000006 putative aspartate binding site [chemical binding]; other site 218493000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 218493000008 dimer interface [polypeptide binding]; other site 218493000009 putative threonine allosteric regulatory site; other site 218493000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 218493000011 putative threonine allosteric regulatory site; other site 218493000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 218493000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218493000021 homoserine kinase; Provisional; Region: PRK01212 218493000022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 218493000027 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 218493000028 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 218493000029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493000030 catalytic residue [active] 218493000033 hypothetical protein; Validated; Region: PRK02101 218493000036 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 218493000037 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 218493000039 9 probable transmembrane helices predicted for SBG0005 by TMHMM2.0 at aa 13-35, 75-97, 137-159, 172-194,204-226, 301-323, 343-365, 386-405 and 415-437 218493000043 transaldolase-like protein; Provisional; Region: PTZ00411 218493000044 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 218493000045 active site 218493000046 dimer interface [polypeptide binding]; other site 218493000047 catalytic residue [active] 218493000051 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 218493000053 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 218493000054 MPT binding site; other site 218493000055 trimer interface [polypeptide binding]; other site 218493000058 hypothetical protein; Provisional; Region: PRK10659 218493000060 6 probable transmembrane helices predicted for SBG0009 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118,125-144 and 148-170 218493000062 hypothetical protein; Provisional; Region: PRK10236 218493000063 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 218493000064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 218493000066 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 218493000067 signal peptide predicted for SBG0011 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 23 and 24 218493000068 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 218493000069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 218493000070 nucleotide binding site [chemical binding]; other site 218493000075 chaperone protein DnaJ; Provisional; Region: PRK10767 218493000076 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218493000077 HSP70 interaction site [polypeptide binding]; other site 218493000078 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 218493000079 substrate binding site [polypeptide binding]; other site 218493000080 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 218493000081 Zn binding sites [ion binding]; other site 218493000082 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 218493000083 dimer interface [polypeptide binding]; other site 218493000091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493000092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493000093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493000094 dimerization interface [polypeptide binding]; other site 218493000096 3 probable transmembrane helices predicted for SBG0016 by TMHMM2.0 at aa 15-37, 50-72 and 77-99 218493000097 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 218493000098 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 218493000099 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 218493000101 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 218493000102 1 probable transmembrane helix predicted for SBG0018 by TMHMM2.0 at aa 127-146 218493000103 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 218493000104 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 218493000105 active site 218493000106 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 218493000107 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 218493000108 aromatic chitin/cellulose binding site residues [chemical binding]; other site 218493000111 homopolymeric tract 6xA 218493000112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218493000113 Helix-turn-helix domain; Region: HTH_36; pfam13730 218493000114 bcf fimbrial operon 218493000115 fimbrial protein BcfA; Provisional; Region: PRK15187 218493000116 signal peptide predicted for SBG0022 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 24 and 25 218493000118 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 218493000119 signal peptide predicted for SBG0023 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 26 and 27 218493000120 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493000121 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493000122 1 probable transmembrane helix predicted for SBG0023 by TMHMM2.0 at aa 7-29 218493000125 signal peptide predicted for SBG0024 by SignalP 2.0 HMM (Signal peptide probabilty 0.941) with cleavage site probability 0.334 between residues 33 and 34 218493000126 outer membrane usher protein; Provisional; Region: PRK15193 218493000127 PapC N-terminal domain; Region: PapC_N; pfam13954 218493000128 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493000129 PapC C-terminal domain; Region: PapC_C; pfam13953 218493000133 Fimbrial protein; Region: Fimbrial; cl01416 218493000134 signal peptide predicted for SBG0025 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 21 and 22 218493000136 Fimbrial protein; Region: Fimbrial; cl01416 218493000137 signal peptide predicted for SBG0026 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.886 between residues 23 and 24 218493000139 Fimbrial protein; Region: Fimbrial; cl01416 218493000140 signal peptide predicted for SBG0027 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.992 between residues 20 and 21 218493000142 fimbrial chaperone BcfG; Provisional; Region: PRK15192 218493000143 signal peptide predicted for SBG0028 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 between residues 22 and 23 218493000144 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493000145 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493000146 1 probable transmembrane helix predicted for SBG0028 by TMHMM2.0 at aa 12-34 218493000149 signal peptide predicted for SBG0029 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 27 and 28 218493000150 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 218493000151 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 218493000152 catalytic residues [active] 218493000154 signal peptide predicted for SBG0030 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.982 between residues 23 and 24 218493000155 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 218493000156 1 probable transmembrane helix predicted for SBG0031 by TMHMM2.0 at aa 128-147 218493000158 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 218493000161 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 218493000162 signal peptide predicted for SBG0033 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.510 between residues 29 and 30 218493000163 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 218493000164 active site 218493000165 metal binding site [ion binding]; metal-binding site 218493000166 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218493000170 signal peptide predicted for SBG0034 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 24 and 25 218493000171 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 218493000173 signal peptide predicted for SBG0035 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.896 between residues 25 and 26 218493000174 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 218493000175 Sulfatase; Region: Sulfatase; pfam00884 218493000176 1 probable transmembrane helix predicted for SBG0035 by TMHMM2.0 at aa 5-27 218493000179 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 218493000180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493000181 FeS/SAM binding site; other site 218493000182 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 218493000184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 218493000186 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 218493000188 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 218493000189 signal peptide predicted for SBG0039 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.437 between residues 31 and 32 218493000191 11 probable transmembrane helices predicted for SBG0039 by TMHMM2.0 at aa 7-29, 59-76, 96-115,125-147, 154-176, 180-202, 215-237, 257-279, 291-313,328-350 and 357-379 218493000192 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 218493000193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493000194 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 218493000195 putative dimerization interface [polypeptide binding]; other site 218493000199 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 218493000201 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 218493000202 1 probable transmembrane helix predicted for SBG0042 by TMHMM2.0 at aa 13-35 218493000203 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 218493000204 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 218493000205 active site 218493000206 Riboflavin kinase; Region: Flavokinase; smart00904 218493000209 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 218493000210 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218493000211 HIGH motif; other site 218493000212 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218493000213 active site 218493000214 KMSKS motif; other site 218493000215 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 218493000216 tRNA binding surface [nucleotide binding]; other site 218493000217 anticodon binding site; other site 218493000218 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218493000223 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 218493000225 4 probable transmembrane helices predicted for SBG0045 by TMHMM2.0 at aa 13-35, 66-88, 100-122 and 137-159 218493000227 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 218493000228 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218493000232 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 218493000233 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 218493000236 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 218493000237 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 218493000238 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 218493000244 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 218493000245 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 218493000246 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 218493000247 catalytic site [active] 218493000248 subunit interface [polypeptide binding]; other site 218493000252 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 218493000253 signal peptide predicted for SBG0052 by SignalP 2.0 HMM (Signal peptide probabilty 0.767) with cleavage site probability 0.700 between residues 23 and 24 218493000254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218493000255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 218493000256 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 218493000257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218493000258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218493000259 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 218493000260 IMP binding site; other site 218493000261 dimer interface [polypeptide binding]; other site 218493000262 interdomain contacts; other site 218493000263 partial ornithine binding site; other site 218493000277 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 218493000278 carnitine operon protein CaiE; Provisional; Region: PRK13627 218493000279 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 218493000280 putative trimer interface [polypeptide binding]; other site 218493000281 putative metal binding site [ion binding]; other site 218493000285 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 218493000286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218493000287 substrate binding site [chemical binding]; other site 218493000288 oxyanion hole (OAH) forming residues; other site 218493000289 trimer interface [polypeptide binding]; other site 218493000292 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 218493000293 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 218493000294 acyl-activating enzyme (AAE) consensus motif; other site 218493000295 putative AMP binding site [chemical binding]; other site 218493000296 putative active site [active] 218493000297 putative CoA binding site [chemical binding]; other site 218493000300 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 218493000301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 218493000303 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 218493000304 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 218493000305 active site 218493000311 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 218493000313 12 probable transmembrane helices predicted for SBG0059 by TMHMM2.0 at aa 13-30, 50-72, 92-114,144-163, 195-214, 229-251, 264-286, 312-334, 347-366,410-432, 445-467 and 472-494 218493000317 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 218493000318 Ligand binding site [chemical binding]; other site 218493000319 Electron transfer flavoprotein domain; Region: ETF; pfam01012 218493000322 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 218493000323 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 218493000324 Ligand binding site [chemical binding]; other site 218493000325 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 218493000329 putative oxidoreductase FixC; Provisional; Region: PRK10157 218493000331 ferredoxin-like protein FixX; Provisional; Region: PRK15449 218493000332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493000333 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 218493000334 putative substrate translocation pore; other site 218493000335 11 probable transmembrane helices predicted for SBG0064 by TMHMM2.0 at aa 19-41, 54-76, 85-104,109-131, 144-166, 171-193, 244-266, 281-303, 324-346,372-394 and 399-421 218493000338 signal peptide predicted for SBG0065 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.606 between residues 26 and 27 218493000339 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493000343 signal peptide predicted for SBG0067 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.502 between residues 19 and 20 218493000344 signal peptide predicted for SBG0068 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493000345 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493000347 1 probable transmembrane helix predicted for SBG0069 by TMHMM2.0 at aa 2-24 218493000348 signal peptide predicted for SBG0070 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.660 between residues 38 and 39 218493000349 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 218493000350 Sulfatase; Region: Sulfatase; cl17466 218493000351 Sulfatase; Region: Sulfatase; cl17466 218493000352 Sulfatase; Region: Sulfatase; cl17466 218493000355 signal peptide predicted for SBG0072 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.606 between residues 26 and 27 218493000356 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493000359 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 218493000361 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 218493000362 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 218493000363 TrkA-N domain; Region: TrkA_N; pfam02254 218493000364 13 probable transmembrane helices predicted for SBG0074 by TMHMM2.0 at aa 5-24, 26-48, 52-74, 86-108,113-135, 148-170, 180-202, 215-234, 238-255, 268-290,296-315, 327-349 and 359-378 218493000368 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 218493000369 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 218493000370 folate binding site [chemical binding]; other site 218493000371 NADP+ binding site [chemical binding]; other site 218493000375 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 218493000376 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 218493000377 active site 218493000378 metal binding site [ion binding]; metal-binding site 218493000380 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 218493000382 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 218493000383 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 218493000386 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 218493000387 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 218493000389 signal peptide predicted for SBG0080 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493000390 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 218493000391 SurA N-terminal domain; Region: SurA_N; pfam09312 218493000392 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 218493000393 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 218493000400 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 218493000401 signal peptide predicted for SBG0081 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 24 and 25 218493000402 OstA-like protein; Region: OstA; pfam03968 218493000403 Organic solvent tolerance protein; Region: OstA_C; pfam04453 218493000406 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 218493000407 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 218493000408 putative metal binding site [ion binding]; other site 218493000409 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218493000410 HSP70 interaction site [polypeptide binding]; other site 218493000411 1 probable transmembrane helix predicted for SBG0082 by TMHMM2.0 at aa 7-29 218493000413 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218493000414 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218493000415 active site 218493000418 ATP-dependent helicase HepA; Validated; Region: PRK04914 218493000419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493000420 ATP binding site [chemical binding]; other site 218493000421 putative Mg++ binding site [ion binding]; other site 218493000422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493000423 nucleotide binding region [chemical binding]; other site 218493000424 ATP-binding site [chemical binding]; other site 218493000427 DNA polymerase II; Reviewed; Region: PRK05762 218493000428 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 218493000429 active site 218493000430 catalytic site [active] 218493000431 substrate binding site [chemical binding]; other site 218493000432 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 218493000433 active site 218493000434 metal-binding site 218493000439 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 218493000440 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 218493000441 intersubunit interface [polypeptide binding]; other site 218493000442 active site 218493000443 Zn2+ binding site [ion binding]; other site 218493000445 L-arabinose isomerase; Provisional; Region: PRK02929 218493000446 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 218493000447 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 218493000448 trimer interface [polypeptide binding]; other site 218493000449 putative substrate binding site [chemical binding]; other site 218493000450 putative metal binding site [ion binding]; other site 218493000452 ribulokinase; Provisional; Region: PRK04123 218493000453 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 218493000454 N- and C-terminal domain interface [polypeptide binding]; other site 218493000455 active site 218493000456 MgATP binding site [chemical binding]; other site 218493000457 catalytic site [active] 218493000458 metal binding site [ion binding]; metal-binding site 218493000459 carbohydrate binding site [chemical binding]; other site 218493000460 homodimer interface [polypeptide binding]; other site 218493000463 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 218493000464 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218493000465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493000466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493000471 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218493000472 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 218493000473 5 probable transmembrane helices predicted for SBG0091 by TMHMM2.0 at aa 13-35, 57-79, 140-162, 177-199 and 218-237 218493000476 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 218493000477 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 218493000478 Walker A/P-loop; other site 218493000479 ATP binding site [chemical binding]; other site 218493000480 Q-loop/lid; other site 218493000481 ABC transporter signature motif; other site 218493000482 Walker B; other site 218493000483 D-loop; other site 218493000484 H-loop/switch region; other site 218493000488 signal peptide predicted for SBG0093 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.721 between residues 29 and 30 218493000489 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 218493000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493000491 dimer interface [polypeptide binding]; other site 218493000492 conserved gate region; other site 218493000493 putative PBP binding loops; other site 218493000494 ABC-ATPase subunit interface; other site 218493000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493000496 dimer interface [polypeptide binding]; other site 218493000497 conserved gate region; other site 218493000498 putative PBP binding loops; other site 218493000499 ABC-ATPase subunit interface; other site 218493000501 12 probable transmembrane helices predicted for SBG0093 by TMHMM2.0 at aa 13-35, 58-80, 92-114,129-151, 199-221, 241-260, 293-315, 335-357, 370-392,407-424, 462-484 and 508-525 218493000503 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 218493000504 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 218493000506 transcriptional regulator SgrR; Provisional; Region: PRK13626 218493000507 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 218493000508 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 218493000510 insertion wrt to St CT18 218493000511 signal peptide predicted for SBG0097 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.485 between residues 30 and 31 218493000512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493000513 sugar efflux transporter; Region: 2A0120; TIGR00899 218493000514 putative substrate translocation pore; other site 218493000515 12 probable transmembrane helices predicted for SBG0097 by TMHMM2.0 at aa 11-33, 48-70, 82-99,104-126, 150-172, 176-198, 220-242, 252-274, 283-302,307-329, 342-364 and 369-387 218493000517 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 218493000518 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 218493000519 substrate binding site [chemical binding]; other site 218493000521 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 218493000522 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 218493000523 substrate binding site [chemical binding]; other site 218493000524 ligand binding site [chemical binding]; other site 218493000528 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 218493000529 tartrate dehydrogenase; Region: TTC; TIGR02089 218493000532 2-isopropylmalate synthase; Validated; Region: PRK00915 218493000533 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 218493000534 active site 218493000535 catalytic residues [active] 218493000536 metal binding site [ion binding]; metal-binding site 218493000537 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 218493000542 Leucine operon leader peptide; Region: Leu_leader; cl15436 218493000544 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 218493000545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493000546 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 218493000547 putative substrate binding pocket [chemical binding]; other site 218493000548 putative dimerization interface [polypeptide binding]; other site 218493000552 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 218493000553 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218493000554 PYR/PP interface [polypeptide binding]; other site 218493000555 dimer interface [polypeptide binding]; other site 218493000556 TPP binding site [chemical binding]; other site 218493000557 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218493000558 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218493000559 TPP-binding site [chemical binding]; other site 218493000560 dimer interface [polypeptide binding]; other site 218493000567 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 218493000568 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218493000569 putative valine binding site [chemical binding]; other site 218493000570 dimer interface [polypeptide binding]; other site 218493000571 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 218493000574 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 218493000575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493000576 DNA binding site [nucleotide binding] 218493000577 domain linker motif; other site 218493000578 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 218493000579 dimerization interface [polypeptide binding]; other site 218493000580 ligand binding site [chemical binding]; other site 218493000584 1 probable transmembrane helix predicted for SBG0107 by TMHMM2.0 at aa 13-32 218493000585 mraZ protein; Region: TIGR00242 218493000586 MraZ protein; Region: MraZ; pfam02381 218493000587 MraZ protein; Region: MraZ; pfam02381 218493000590 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 218493000591 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 218493000593 cell division protein FtsL; Provisional; Region: PRK10772 218493000595 1 probable transmembrane helix predicted for SBG0110 by TMHMM2.0 at aa 35-57 218493000596 signal peptide predicted for SBG0111 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.615 between residues 42 and 43 218493000597 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 218493000598 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218493000599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218493000600 1 probable transmembrane helix predicted for SBG0111 by TMHMM2.0 at aa 21-43 218493000603 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 218493000604 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218493000605 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493000606 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493000610 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 218493000611 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218493000612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493000613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493000617 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 218493000618 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 218493000619 Mg++ binding site [ion binding]; other site 218493000620 putative catalytic motif [active] 218493000621 putative substrate binding site [chemical binding]; other site 218493000622 10 probable transmembrane helices predicted for SBG0114 by TMHMM2.0 at aa 15-37, 75-92, 97-114,134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 218493000624 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 218493000625 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493000626 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493000627 1 probable transmembrane helix predicted for SBG0115 by TMHMM2.0 at aa 9-31 218493000632 cell division protein FtsW; Provisional; Region: PRK10774 218493000634 10 probable transmembrane helices predicted for SBG0116 by TMHMM2.0 at aa 20-42, 57-78, 85-107,117-136, 148-165, 169-188, 193-215, 278-300, 312-334 and 344-366 218493000636 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 218493000637 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 218493000638 active site 218493000639 homodimer interface [polypeptide binding]; other site 218493000642 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 218493000643 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218493000644 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493000645 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493000649 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 218493000650 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218493000651 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 218493000657 cell division protein FtsQ; Provisional; Region: PRK10775 218493000658 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 218493000659 Cell division protein FtsQ; Region: FtsQ; pfam03799 218493000660 1 probable transmembrane helix predicted for SBG0120 by TMHMM2.0 at aa 26-48 218493000663 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 218493000664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493000665 Cell division protein FtsA; Region: FtsA; pfam14450 218493000669 cell division protein FtsZ; Validated; Region: PRK09330 218493000670 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 218493000671 nucleotide binding site [chemical binding]; other site 218493000672 SulA interaction site; other site 218493000673 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 218493000678 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 218493000679 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 218493000681 SecA regulator SecM; Provisional; Region: PRK02943 218493000682 signal peptide predicted for SBG0124 by SignalP 2.0 HMM (Signal peptide probabilty 0.718) with cleavage site probability 0.643 between residues 14 and 15 218493000684 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 218493000685 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 218493000686 SEC-C motif; Region: SEC-C; pfam02810 218493000692 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 218493000693 active site 218493000694 8-oxo-dGMP binding site [chemical binding]; other site 218493000695 nudix motif; other site 218493000696 metal binding site [ion binding]; metal-binding site 218493000699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493000700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493000701 active site 218493000702 catalytic tetrad [active] 218493000704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493000705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493000706 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218493000707 putative effector binding pocket; other site 218493000708 putative dimerization interface [polypeptide binding]; other site 218493000712 DNA gyrase inhibitor; Reviewed; Region: PRK00418 218493000714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 218493000716 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 218493000717 signal peptide predicted for SBG0131 by SignalP 2.0 HMM (Signal peptide probabilty 0.652) with cleavage site probability 0.233 between residues 19 and 20 218493000718 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 218493000719 CoA-binding site [chemical binding]; other site 218493000720 ATP-binding [chemical binding]; other site 218493000724 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 218493000725 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 218493000726 active site 218493000729 type IV pilin biogenesis protein; Provisional; Region: PRK10573 218493000730 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218493000731 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218493000732 3 probable transmembrane helices predicted for SBG0133 by TMHMM2.0 at aa 123-145, 167-189 and 328-350 218493000735 hypothetical protein; Provisional; Region: PRK10436 218493000736 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 218493000737 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 218493000738 Walker A motif; other site 218493000739 ATP binding site [chemical binding]; other site 218493000740 Walker B motif; other site 218493000745 putative major pilin subunit; Provisional; Region: PRK10574 218493000746 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 218493000747 1 probable transmembrane helix predicted for SBG0135 by TMHMM2.0 at aa 7-29 218493000750 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 218493000751 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 218493000752 dimerization interface [polypeptide binding]; other site 218493000753 active site 218493000756 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 218493000757 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 218493000758 amidase catalytic site [active] 218493000759 substrate binding site [chemical binding]; other site 218493000760 Zn binding residues [ion binding]; other site 218493000762 regulatory protein AmpE; Provisional; Region: PRK10987 218493000763 4 probable transmembrane helices predicted for SBG0138 by TMHMM2.0 at aa 41-58, 63-85, 146-168 and 266-283 218493000764 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 218493000765 active site 218493000767 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218493000768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493000769 putative substrate translocation pore; other site 218493000770 12 probable transmembrane helices predicted for SBG0140 by TMHMM2.0 at aa 12-31, 35-57, 81-100,115-137, 150-172, 182-204, 234-256, 266-288, 295-317,322-344, 365-387 and 407-429 218493000774 aromatic amino acid transporter; Provisional; Region: PRK10238 218493000776 12 probable transmembrane helices predicted for SBG0141 by TMHMM2.0 at aa 21-43, 47-66, 86-108,118-140, 153-175, 198-220, 240-262, 282-304, 331-353,357-379, 399-421 and 426-445 218493000778 This CDS has a frameshift following codon 63 and lacks a translational stop codon 218493000780 This CDS lies within a region highly similar to the uropathogen specific island of E.coli encoding the Ups virulence proteins. However, this CDS lacks an appropriate translational start site at a position matching the Usp group of proteins. In addition sequence identity to pyocins suggests that this CDS is longer than would be predicted by comparisons with Usp proteins alone and so the N-terminal region has been extended. This CDS also appears to carry a frameshift mutation following codon 375. The 3' region of this CDS is duplicated at position 161333..161692 encoding SBG_0144 218493000783 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 218493000785 This partial CDS is duplicated at position 160525..161170 encoding SBG_0142 218493000787 similarity to the uropathogenic E. coli protein found within the Usp pathogenicity island. This CDS carries a premature stop codon following codon 84 218493000789 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 218493000790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493000791 DNA-binding site [nucleotide binding]; DNA binding site 218493000792 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493000796 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 218493000797 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 218493000798 dimer interface [polypeptide binding]; other site 218493000799 TPP-binding site [chemical binding]; other site 218493000801 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 218493000802 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218493000803 E3 interaction surface; other site 218493000804 lipoyl attachment site [posttranslational modification]; other site 218493000805 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218493000806 E3 interaction surface; other site 218493000807 lipoyl attachment site [posttranslational modification]; other site 218493000808 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218493000809 E3 interaction surface; other site 218493000810 lipoyl attachment site [posttranslational modification]; other site 218493000811 e3 binding domain; Region: E3_binding; pfam02817 218493000812 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218493000821 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 218493000822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 218493000823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493000824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218493000829 signal peptide predicted for SBG0150 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22 218493000830 signal peptide predicted for SBG0151 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.596 between residues 34 and 35 218493000831 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 218493000832 signal peptide predicted for SBG0152 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.467 between residues 27 and 28 218493000833 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 218493000835 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 218493000836 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 218493000837 substrate binding site [chemical binding]; other site 218493000838 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 218493000839 substrate binding site [chemical binding]; other site 218493000840 ligand binding site [chemical binding]; other site 218493000845 hypothetical protein; Provisional; Region: PRK05248 218493000851 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 218493000853 spermidine synthase; Provisional; Region: PRK00811 218493000854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493000855 S-adenosylmethionine binding site [chemical binding]; other site 218493000859 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 218493000860 signal peptide predicted for SBG0159 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.849 between residues 22 and 23 218493000861 multicopper oxidase; Provisional; Region: PRK10965 218493000862 signal peptide predicted for SBG0160 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 28 and 29 218493000863 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 218493000864 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 218493000868 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 218493000869 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 218493000870 Trp docking motif [polypeptide binding]; other site 218493000871 putative active site [active] 218493000880 5 probable transmembrane helices predicted for SBG0161 by TMHMM2.0 at aa 13-35, 40-57, 64-81, 96-114 and 121-140 218493000881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493000882 active site 218493000885 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 218493000886 active site clefts [active] 218493000887 zinc binding site [ion binding]; other site 218493000888 dimer interface [polypeptide binding]; other site 218493000892 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218493000893 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218493000894 Walker A/P-loop; other site 218493000895 ATP binding site [chemical binding]; other site 218493000896 Q-loop/lid; other site 218493000897 ABC transporter signature motif; other site 218493000898 Walker B; other site 218493000899 D-loop; other site 218493000900 H-loop/switch region; other site 218493000904 inner membrane transport permease; Provisional; Region: PRK15066 218493000905 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218493000907 6 probable transmembrane helices predicted for SBG0165 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163,170-192 and 226-248 218493000909 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493000910 active pocket/dimerization site; other site 218493000911 active site 218493000912 phosphorylation site [posttranslational modification] 218493000914 signal peptide predicted for SBG0167 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.582 between residues 20 and 21 218493000915 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 218493000916 putative active site [active] 218493000917 putative metal binding site [ion binding]; other site 218493000919 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 218493000920 tetramerization interface [polypeptide binding]; other site 218493000921 active site 218493000924 hypothetical protein; Provisional; Region: PRK09956 218493000925 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 218493000927 pantoate--beta-alanine ligase; Region: panC; TIGR00018 218493000928 Pantoate-beta-alanine ligase; Region: PanC; cd00560 218493000929 active site 218493000930 ATP-binding site [chemical binding]; other site 218493000931 pantoate-binding site; other site 218493000932 HXXH motif; other site 218493000934 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 218493000935 oligomerization interface [polypeptide binding]; other site 218493000936 active site 218493000937 metal binding site [ion binding]; metal-binding site 218493000939 sba fimbrial operon 218493000940 signal peptide predicted for SBG0172 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 39 and 40 218493000941 Fimbrial protein; Region: Fimbrial; cl01416 218493000943 1 probable transmembrane helix predicted for SBG0172 by TMHMM2.0 at aa 17-39 218493000944 signal peptide predicted for SBG0173 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493000945 Fimbrial protein; Region: Fimbrial; cl01416 218493000947 signal peptide predicted for SBG0174 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.956 between residues 23 and 24 218493000948 putative fimbrial protein StaE; Provisional; Region: PRK15263 218493000950 signal peptide predicted for SBG0175 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.885 between residues 23 and 24 218493000951 Fimbrial protein; Region: Fimbrial; cl01416 218493000952 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 218493000953 signal peptide predicted for SBG0176 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 30 and 31 218493000954 PapC N-terminal domain; Region: PapC_N; pfam13954 218493000955 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493000956 PapC C-terminal domain; Region: PapC_C; pfam13953 218493000961 signal peptide predicted for SBG0177 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 26 and 27 218493000962 putative chaperone protein EcpD; Provisional; Region: PRK09926 218493000963 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493000964 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493000968 1 probable transmembrane helix predicted for SBG0177 by TMHMM2.0 at aa 7-26 218493000969 Fimbrial protein; Region: Fimbrial; cl01416 218493000970 signal peptide predicted for SBG0178 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22 218493000972 Fimbrial protein; Region: Fimbrial; cl01416 218493000974 signal peptide predicted for SBG0179 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 36 and 37 218493000975 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 218493000976 catalytic center binding site [active] 218493000977 ATP binding site [chemical binding]; other site 218493000980 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 218493000981 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218493000982 active site 218493000983 NTP binding site [chemical binding]; other site 218493000984 metal binding triad [ion binding]; metal-binding site 218493000985 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218493000986 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 218493000988 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 218493000989 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 218493000990 active site 218493000991 nucleotide binding site [chemical binding]; other site 218493000992 HIGH motif; other site 218493000993 KMSKS motif; other site 218493000995 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 218493000998 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 218493001001 2'-5' RNA ligase; Provisional; Region: PRK15124 218493001002 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 218493001003 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 218493001006 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 218493001007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493001008 ATP binding site [chemical binding]; other site 218493001009 putative Mg++ binding site [ion binding]; other site 218493001010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493001011 nucleotide binding region [chemical binding]; other site 218493001012 ATP-binding site [chemical binding]; other site 218493001013 Helicase associated domain (HA2); Region: HA2; pfam04408 218493001014 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 218493001021 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 218493001022 Transglycosylase; Region: Transgly; pfam00912 218493001023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218493001024 1 probable transmembrane helix predicted for SBG0187 by TMHMM2.0 at aa 60-82 218493001028 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 218493001029 signal peptide predicted for SBG0188 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 33 and 34 218493001030 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493001031 N-terminal plug; other site 218493001032 ligand-binding site [chemical binding]; other site 218493001037 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 218493001038 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218493001039 Walker A/P-loop; other site 218493001040 ATP binding site [chemical binding]; other site 218493001041 Q-loop/lid; other site 218493001042 ABC transporter signature motif; other site 218493001043 Walker B; other site 218493001044 D-loop; other site 218493001045 H-loop/switch region; other site 218493001049 signal peptide predicted for SBG0190 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.962 between residues 30 and 31 218493001050 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 218493001051 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218493001052 siderophore binding site; other site 218493001056 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218493001057 signal peptide predicted for SBG0191 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.606 between residues 20 and 21 218493001058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493001059 ABC-ATPase subunit interface; other site 218493001060 dimer interface [polypeptide binding]; other site 218493001061 putative PBP binding regions; other site 218493001062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493001063 ABC-ATPase subunit interface; other site 218493001064 dimer interface [polypeptide binding]; other site 218493001065 putative PBP binding regions; other site 218493001066 16 probable transmembrane helices predicted for SBG0191 by TMHMM2.0 at aa 7-26, 57-79, 92-111,115-137, 144-166, 239-261, 273-291, 301-323, 347-369,389-411, 424-442, 446-468, 480-499, 567-589, 601-623 and 633-655 218493001071 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 218493001072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493001073 inhibitor-cofactor binding pocket; inhibition site 218493001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493001075 catalytic residue [active] 218493001079 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 218493001080 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 218493001081 Cl- selectivity filter; other site 218493001082 Cl- binding residues [ion binding]; other site 218493001083 pore gating glutamate residue; other site 218493001084 dimer interface [polypeptide binding]; other site 218493001085 H+/Cl- coupling transport residue; other site 218493001086 11 probable transmembrane helices predicted for SBG0193 by TMHMM2.0 at aa 31-53, 75-97, 124-146,179-201, 210-232, 252-274, 291-310, 320-342, 355-377,390-412 and 419-441 218493001089 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 218493001092 hypothetical protein; Provisional; Region: PRK10578 218493001093 UPF0126 domain; Region: UPF0126; pfam03458 218493001094 UPF0126 domain; Region: UPF0126; pfam03458 218493001096 6 probable transmembrane helices predicted for SBG0195 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-105,115-137 and 149-171 218493001098 signal peptide predicted for SBG0196 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.827 between residues 22 and 23 218493001099 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 218493001100 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 218493001101 cobalamin binding residues [chemical binding]; other site 218493001102 putative BtuC binding residues; other site 218493001103 dimer interface [polypeptide binding]; other site 218493001105 1 probable transmembrane helix predicted for SBG0196 by TMHMM2.0 at aa 5-27 218493001106 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 218493001107 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 218493001109 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 218493001110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218493001111 Zn2+ binding site [ion binding]; other site 218493001112 Mg2+ binding site [ion binding]; other site 218493001113 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 218493001115 signal peptide predicted for SBG0199 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 26 and 27 218493001116 serine endoprotease; Provisional; Region: PRK10942 218493001117 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218493001118 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218493001119 protein binding site [polypeptide binding]; other site 218493001120 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218493001124 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 218493001125 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 218493001126 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 218493001128 insertion wrt to St CT18 218493001129 Viral enhancin protein; Region: Enhancin; pfam03272 218493001130 Peptidase M60-like family; Region: M60-like; pfam13402 218493001133 hypothetical protein; Provisional; Region: PRK13677 218493001134 shikimate transporter; Provisional; Region: PRK09952 218493001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493001136 putative substrate translocation pore; other site 218493001137 12 probable transmembrane helices predicted for SBG0203 by TMHMM2.0 at aa 13-35, 50-72, 85-107,117-139, 151-173, 183-202, 247-269, 279-301, 310-329,333-350, 370-392 and 402-421 218493001140 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 218493001141 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 218493001142 trimer interface [polypeptide binding]; other site 218493001143 active site 218493001144 substrate binding site [chemical binding]; other site 218493001145 CoA binding site [chemical binding]; other site 218493001151 PII uridylyl-transferase; Provisional; Region: PRK05007 218493001152 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218493001153 metal binding triad; other site 218493001154 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218493001155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218493001156 Zn2+ binding site [ion binding]; other site 218493001157 Mg2+ binding site [ion binding]; other site 218493001158 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 218493001159 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 218493001165 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 218493001166 active site 218493001169 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 218493001170 rRNA interaction site [nucleotide binding]; other site 218493001171 S8 interaction site; other site 218493001172 putative laminin-1 binding site; other site 218493001176 elongation factor Ts; Provisional; Region: tsf; PRK09377 218493001177 UBA/TS-N domain; Region: UBA; pfam00627 218493001178 Elongation factor TS; Region: EF_TS; pfam00889 218493001179 Elongation factor TS; Region: EF_TS; pfam00889 218493001184 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 218493001185 putative nucleotide binding site [chemical binding]; other site 218493001186 uridine monophosphate binding site [chemical binding]; other site 218493001187 homohexameric interface [polypeptide binding]; other site 218493001189 ribosome recycling factor; Reviewed; Region: frr; PRK00083 218493001190 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 218493001191 hinge region; other site 218493001193 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 218493001194 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 218493001195 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 218493001196 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 218493001201 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 218493001202 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 218493001203 catalytic residue [active] 218493001204 putative FPP diphosphate binding site; other site 218493001205 putative FPP binding hydrophobic cleft; other site 218493001206 dimer interface [polypeptide binding]; other site 218493001207 putative IPP diphosphate binding site; other site 218493001210 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 218493001211 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 218493001212 signal peptide predicted for SBG0213 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.934 between residues 29 and 30 218493001214 8 probable transmembrane helices predicted for SBG0213 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143,150-172, 192-211, 218-240 and 260-282 218493001216 zinc metallopeptidase RseP; Provisional; Region: PRK10779 218493001217 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218493001218 active site 218493001219 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 218493001220 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 218493001221 protein binding site [polypeptide binding]; other site 218493001222 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218493001223 putative substrate binding region [chemical binding]; other site 218493001224 4 probable transmembrane helices predicted for SBG0214 by TMHMM2.0 at aa 2-21, 98-120, 376-398 and 426-445 218493001228 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 218493001229 signal peptide predicted for SBG0215 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.963 between residues 20 and 21 218493001230 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493001231 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493001232 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493001233 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493001234 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493001235 Surface antigen; Region: Bac_surface_Ag; pfam01103 218493001242 periplasmic chaperone; Provisional; Region: PRK10780 218493001243 signal peptide predicted for SBG0216 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493001244 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 218493001246 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 218493001247 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 218493001248 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 218493001249 trimer interface [polypeptide binding]; other site 218493001250 active site 218493001251 UDP-GlcNAc binding site [chemical binding]; other site 218493001252 lipid binding site [chemical binding]; lipid-binding site 218493001265 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 218493001267 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 218493001268 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 218493001269 active site 218493001280 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 218493001281 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 218493001283 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 218493001284 RNA/DNA hybrid binding site [nucleotide binding]; other site 218493001285 active site 218493001287 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 218493001288 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 218493001289 putative active site [active] 218493001290 putative PHP Thumb interface [polypeptide binding]; other site 218493001291 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 218493001292 generic binding surface II; other site 218493001293 generic binding surface I; other site 218493001297 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 218493001298 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 218493001300 signal peptide predicted for SBG0224 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 25 and 26 218493001301 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 218493001302 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 218493001303 putative sugar binding site [chemical binding]; other site 218493001304 catalytic residues [active] 218493001305 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 218493001306 1 probable transmembrane helix predicted for SBG0224 by TMHMM2.0 at aa 7-29 218493001310 lysine decarboxylase LdcC; Provisional; Region: PRK15399 218493001311 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218493001312 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218493001313 homodimer interface [polypeptide binding]; other site 218493001314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493001315 catalytic residue [active] 218493001316 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218493001321 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 218493001322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218493001323 putative metal binding site [ion binding]; other site 218493001325 signal peptide predicted for SBG0227 by SignalP 2.0 HMM (Signal peptide probabilty 0.650) with cleavage site probability 0.512 between residues 18 and 19 218493001326 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 218493001327 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218493001328 Ligand Binding Site [chemical binding]; other site 218493001329 TilS substrate binding domain; Region: TilS; pfam09179 218493001330 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 218493001333 Rho-binding antiterminator; Provisional; Region: PRK11625 218493001335 hypothetical protein; Provisional; Region: PRK04964 218493001337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 218493001339 hypothetical protein; Provisional; Region: PRK09256 218493001340 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 218493001343 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 218493001344 signal peptide predicted for SBG0232 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.627 between residues 35 and 36 218493001345 NlpE N-terminal domain; Region: NlpE; pfam04170 218493001349 prolyl-tRNA synthetase; Provisional; Region: PRK09194 218493001350 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 218493001351 dimer interface [polypeptide binding]; other site 218493001352 motif 1; other site 218493001353 active site 218493001354 motif 2; other site 218493001355 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 218493001356 putative deacylase active site [active] 218493001357 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218493001358 active site 218493001359 motif 3; other site 218493001360 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 218493001361 anticodon binding site; other site 218493001366 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 218493001367 homodimer interaction site [polypeptide binding]; other site 218493001368 cofactor binding site; other site 218493001371 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 218493001372 signal peptide predicted for SBG0235 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.384 between residues 21 and 22 218493001374 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 218493001375 signal peptide predicted for SBG0236 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.735 between residues 22 and 23 218493001376 lipoprotein, YaeC family; Region: TIGR00363 218493001379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493001380 dimer interface [polypeptide binding]; other site 218493001381 conserved gate region; other site 218493001382 ABC-ATPase subunit interface; other site 218493001384 5 probable transmembrane helices predicted for SBG0237 by TMHMM2.0 at aa 13-35, 55-73, 77-99, 139-161 and 176-198 218493001386 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 218493001387 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 218493001388 Walker A/P-loop; other site 218493001389 ATP binding site [chemical binding]; other site 218493001390 Q-loop/lid; other site 218493001391 ABC transporter signature motif; other site 218493001392 Walker B; other site 218493001393 D-loop; other site 218493001394 H-loop/switch region; other site 218493001395 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 218493001399 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 218493001400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493001401 active site 218493001402 motif I; other site 218493001403 motif II; other site 218493001405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493001406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493001407 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 218493001408 putative effector binding pocket; other site 218493001409 dimerization interface [polypeptide binding]; other site 218493001413 hypothetical protein; Provisional; Region: PRK05421 218493001414 putative catalytic site [active] 218493001415 putative metal binding site [ion binding]; other site 218493001416 putative phosphate binding site [ion binding]; other site 218493001417 putative catalytic site [active] 218493001418 putative phosphate binding site [ion binding]; other site 218493001419 putative metal binding site [ion binding]; other site 218493001421 Methyltransferase domain; Region: Methyltransf_23; pfam13489 218493001422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493001423 S-adenosylmethionine binding site [chemical binding]; other site 218493001425 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 218493001426 signal peptide predicted for SBG0243 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.546 between residues 21 and 22 218493001427 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493001428 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493001429 catalytic residue [active] 218493001430 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493001431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493001438 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 218493001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493001442 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 218493001443 RNA/DNA hybrid binding site [nucleotide binding]; other site 218493001444 active site 218493001446 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 218493001447 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 218493001448 active site 218493001449 catalytic site [active] 218493001450 substrate binding site [chemical binding]; other site 218493001452 signal peptide predicted for SBG0248 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.944 between residues 19 and 20 218493001453 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 218493001455 signal peptide predicted for SBG0249 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.824 between residues 26 and 27 218493001456 Autotransporter beta-domain; Region: Autotransporter; smart00869 218493001458 signal peptide predicted for SBG0250 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.726 between residues 23 and 24 218493001459 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218493001460 dimer interface [polypeptide binding]; other site 218493001463 1 probable transmembrane helix predicted for SBG0250 by TMHMM2.0 at aa 7-26 218493001464 C-N hydrolase family amidase; Provisional; Region: PRK10438 218493001465 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 218493001466 putative active site [active] 218493001467 catalytic triad [active] 218493001468 dimer interface [polypeptide binding]; other site 218493001469 multimer interface [polypeptide binding]; other site 218493001471 signal peptide predicted for SBG0252 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.466 between residues 32 and 33 218493001472 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 218493001473 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 218493001474 active site 218493001475 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 218493001478 2 probable transmembrane helices predicted for SBG0252 by TMHMM2.0 at aa 10-32 and 39-61 218493001479 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 218493001480 dimer interface [polypeptide binding]; other site 218493001481 active site 218493001483 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 218493001484 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 218493001485 putative active site [active] 218493001486 putative dimer interface [polypeptide binding]; other site 218493001488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 218493001489 signal peptide predicted for SBG0255 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.629 between residues 19 and 20 218493001490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493001493 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 218493001494 active site 218493001495 DNA polymerase IV; Validated; Region: PRK02406 218493001496 DNA binding site [nucleotide binding] 218493001498 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 218493001499 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 218493001500 metal binding site [ion binding]; metal-binding site 218493001501 dimer interface [polypeptide binding]; other site 218493001504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493001505 active site 218493001508 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 218493001510 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 218493001512 gamma-glutamyl kinase; Provisional; Region: PRK05429 218493001513 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 218493001514 nucleotide binding site [chemical binding]; other site 218493001515 homotetrameric interface [polypeptide binding]; other site 218493001516 putative phosphate binding site [ion binding]; other site 218493001517 putative allosteric binding site; other site 218493001518 PUA domain; Region: PUA; pfam01472 218493001522 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 218493001523 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 218493001524 putative catalytic cysteine [active] 218493001527 SB30 similar in parts to E. coli CP4-6 prophage 218493001528 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 218493001530 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 218493001532 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 218493001533 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 218493001534 HsdM N-terminal domain; Region: HsdM_N; pfam12161 218493001535 Methyltransferase domain; Region: Methyltransf_26; pfam13659 218493001536 S-adenosylmethionine binding site [chemical binding]; other site 218493001539 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 218493001540 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218493001541 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218493001544 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 218493001545 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 218493001546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493001547 ATP binding site [chemical binding]; other site 218493001548 putative Mg++ binding site [ion binding]; other site 218493001552 2 probable transmembrane helices predicted for SBG0272 by TMHMM2.0 at aa 21-43 and 53-75 218493001553 WYL domain; Region: WYL; pfam13280 218493001554 signal peptide predicted for SBG0275 by SignalP 2.0 HMM (Signal peptide probabilty 0.849) with cleavage site probability 0.820 between residues 57 and 58 218493001555 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 218493001557 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 218493001559 Domain of unknown function (DUF932); Region: DUF932; pfam06067 218493001561 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218493001562 MPN+ (JAMM) motif; other site 218493001563 Zinc-binding site [ion binding]; other site 218493001566 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 218493001568 Methyltransferase domain; Region: Methyltransf_27; pfam13708 218493001569 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 218493001570 ADP-ribose binding site [chemical binding]; other site 218493001572 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218493001573 active site 218493001574 Int/Topo IB signature motif; other site 218493001576 signal peptide predicted for SBG0285 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.779 between residues 22 and 23 218493001577 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 218493001578 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493001579 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493001580 catalytic residue [active] 218493001581 fimbrial operon sbe 218493001583 Toxin-coregulated pilus subunit TcpA; Region: TcpA; pfam05946 218493001586 1 probable transmembrane helix predicted for SBG0287 by TMHMM2.0 at aa 33-55 218493001588 signal peptide predicted for SBG0288 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.693 between residues 28 and 29 218493001589 K+-transporting ATPase, c chain; Region: KdpC; cl00944 218493001590 1 probable transmembrane helix predicted for SBG0288 by TMHMM2.0 at aa 7-29 218493001591 signal peptide predicted for SBG0289 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.850 between residues 26 and 27 218493001592 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 218493001593 1 probable transmembrane helix predicted for SBG0289 by TMHMM2.0 at aa 10-27 218493001594 signal peptide predicted for SBG0290 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.563 between residues 18 and 19 218493001595 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 218493001596 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218493001598 1 probable transmembrane helix predicted for SBG0291 by TMHMM2.0 at aa 180-202 218493001599 signal peptide predicted for SBG0292 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.857 between residues 51 and 52 218493001600 1 probable transmembrane helix predicted for SBG0292 by TMHMM2.0 at aa 35-57 218493001601 signal peptide predicted for SBG0293 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.930 between residues 21 and 22 218493001602 Type II/IV secretion system protein; Region: T2SE; pfam00437 218493001603 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218493001604 Walker A motif; other site 218493001605 ATP binding site [chemical binding]; other site 218493001606 Walker B motif; other site 218493001610 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218493001611 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218493001614 3 probable transmembrane helices predicted for SBG0295 by TMHMM2.0 at aa 108-130, 164-186 and 306-328 218493001616 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 218493001617 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 218493001618 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 218493001619 7 probable transmembrane helices predicted for SBG0296 by TMHMM2.0 at aa 10-32, 87-109, 114-133, 145-164,168-187, 208-230 and 250-272 218493001624 signal peptide predicted for SBG0297 by SignalP 2.0 HMM (Signal peptide probabilty 0.805) with cleavage site probability 0.415 between residues 53 and 54 218493001625 1 probable transmembrane helix predicted for SBG0297 by TMHMM2.0 at aa 36-58 218493001626 fimbrial operon sbb 218493001627 signal peptide predicted for SBG0298 by SignalP 2.0 HMM (Signal peptide probabilty 0.619) with cleavage site probability 0.595 between residues 23 and 24 218493001628 Fimbrial protein; Region: Fimbrial; pfam00419 218493001630 signal peptide predicted for SBG0299 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.990 between residues 27 and 28 218493001631 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 218493001632 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493001633 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493001637 signal peptide predicted for SBG0300 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.819 between residues 21 and 22 218493001638 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 218493001639 PapC N-terminal domain; Region: PapC_N; pfam13954 218493001640 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493001641 PapC C-terminal domain; Region: PapC_C; pfam13953 218493001643 signal peptide predicted for SBG0301 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.877 between residues 23 and 24 218493001644 Fimbrial protein; Region: Fimbrial; cl01416 218493001646 1 probable transmembrane helix predicted for SBG0301 by TMHMM2.0 at aa 7-29 218493001647 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 218493001649 transcriptional activator SprB; Provisional; Region: PRK15320 218493001650 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 218493001651 DNA binding residues [nucleotide binding] 218493001652 negative regulator GrlR; Provisional; Region: PRK14051 218493001653 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 218493001657 signal peptide predicted for SBG0306 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.408 between residues 26 and 27 218493001658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 218493001660 12 probable transmembrane helices predicted for SBG0306 by TMHMM2.0 at aa 7-29, 339-361, 368-390,396-418, 439-461, 476-498, 543-565, 882-899, 906-928,933-955, 983-1005 and 1015-1037 218493001662 signal peptide predicted for SBG0307 by SignalP 2.0 HMM (Signal peptide probabilty 0.828) with cleavage site probability 0.432 between residues 24 and 25 218493001663 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 218493001664 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493001665 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493001667 1 probable transmembrane helix predicted for SBG0307 by TMHMM2.0 at aa 7-29 218493001668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 218493001669 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218493001670 metal-binding site [ion binding] 218493001671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493001672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493001673 motif II; other site 218493001676 8 probable transmembrane helices predicted for SBG0308 by TMHMM2.0 at aa 121-143, 158-178, 191-213,223-241, 375-397, 402-424, 718-740 and 744-766 218493001681 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 218493001682 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 218493001683 DNA binding residues [nucleotide binding] 218493001684 dimer interface [polypeptide binding]; other site 218493001685 copper binding site [ion binding]; other site 218493001689 putative sialic acid transporter; Region: 2A0112; TIGR00891 218493001690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493001691 putative substrate translocation pore; other site 218493001692 10 probable transmembrane helices predicted for SBG0311 by TMHMM2.0 at aa 13-35, 50-72, 79-101,105-127, 140-162, 172-194, 215-232, 252-274, 287-309 and 370-392 218493001695 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 218493001696 DNA methylase; Region: N6_N4_Mtase; cl17433 218493001697 DNA methylase; Region: N6_N4_Mtase; pfam01555 218493001698 DNA methylase; Region: N6_N4_Mtase; cl17433 218493001702 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 218493001703 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 218493001704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 218493001705 VRR-NUC domain; Region: VRR_NUC; pfam08774 218493001709 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 218493001711 9 probable transmembrane helices predicted for SBG0315 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148,185-207, 220-237, 322-344, 357-379 and 407-429 218493001712 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 218493001713 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218493001715 8 probable transmembrane helices predicted for SBG0316 by TMHMM2.0 at aa 7-26, 77-99, 119-141, 156-178,198-220, 230-248, 261-283 and 303-325 218493001716 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 218493001718 5 probable transmembrane helices predicted for SBG0317 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 145-167 and 187-204 218493001719 hypothetical protein; Provisional; Region: PRK09929 218493001720 signal peptide predicted for SBG0318 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22 218493001722 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 218493001723 Propionate catabolism activator; Region: PrpR_N; pfam06506 218493001724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493001725 Walker A motif; other site 218493001726 ATP binding site [chemical binding]; other site 218493001727 Walker B motif; other site 218493001728 arginine finger; other site 218493001729 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218493001736 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 218493001737 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 218493001738 tetramer interface [polypeptide binding]; other site 218493001739 active site 218493001740 Mg2+/Mn2+ binding site [ion binding]; other site 218493001742 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 218493001743 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 218493001744 dimer interface [polypeptide binding]; other site 218493001745 active site 218493001746 citrylCoA binding site [chemical binding]; other site 218493001747 oxalacetate/citrate binding site [chemical binding]; other site 218493001748 coenzyme A binding site [chemical binding]; other site 218493001749 catalytic triad [active] 218493001753 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 218493001754 2-methylcitrate dehydratase; Region: prpD; TIGR02330 218493001756 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 218493001757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218493001758 acyl-activating enzyme (AAE) consensus motif; other site 218493001759 AMP binding site [chemical binding]; other site 218493001760 active site 218493001761 CoA binding site [chemical binding]; other site 218493001764 insertion wrt to St CT18 carrying the LacZ gene 218493001765 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 218493001766 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 218493001767 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 218493001768 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 218493001769 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 218493001776 hypothetical protein; Provisional; Region: PRK12378 218493001778 lac repressor; Reviewed; Region: lacI; PRK09526 218493001779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493001780 DNA binding site [nucleotide binding] 218493001781 domain linker motif; other site 218493001782 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 218493001783 ligand binding site [chemical binding]; other site 218493001784 dimerization interface (open form) [polypeptide binding]; other site 218493001785 dimerization interface (closed form) [polypeptide binding]; other site 218493001789 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 218493001790 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 218493001793 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 218493001794 dimer interface [polypeptide binding]; other site 218493001795 active site 218493001796 Schiff base residues; other site 218493001799 signal peptide predicted for SBG0329 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 27 and 28 218493001800 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 218493001801 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 218493001802 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218493001804 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 218493001805 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218493001806 ligand binding site [chemical binding]; other site 218493001807 flexible hinge region; other site 218493001809 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 218493001810 signal peptide predicted for SBG0331 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 21 and 22 218493001811 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 218493001814 signal peptide predicted for SBG0332 by SignalP 2.0 HMM (Signal peptide probabilty 0.772) with cleavage site probability 0.204 between residues 35 and 36 218493001815 microcin B17 transporter; Reviewed; Region: PRK11098 218493001816 8 probable transmembrane helices predicted for SBG0332 by TMHMM2.0 at aa 12-34, 57-79, 86-108, 138-160,206-228, 243-265, 309-327 and 331-353 218493001818 signal peptide predicted for SBG0333 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.455 between residues 25 and 26 218493001819 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 218493001822 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 218493001823 2 probable transmembrane helices predicted for SBG0334 by TMHMM2.0 at aa 25-47 and 68-90 218493001825 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 218493001826 2 probable transmembrane helices predicted for SBG0335 by TMHMM2.0 at aa 13-32 and 37-59 218493001827 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 218493001828 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218493001829 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 218493001835 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 218493001837 signal peptide predicted for SBG0338 by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.626 between residues 23 and 24 218493001838 drug efflux system protein MdtG; Provisional; Region: PRK09874 218493001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493001840 putative substrate translocation pore; other site 218493001841 10 probable transmembrane helices predicted for SBG0338 by TMHMM2.0 at aa 7-29, 44-66, 79-101,161-183, 204-226, 249-271, 283-302, 307-329, 342-364 and 369-391 218493001843 anti-RssB factor; Provisional; Region: PRK10244 218493001844 signal peptide predicted for SBG0340 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.905 between residues 21 and 22 218493001845 hypothetical protein; Provisional; Region: PRK11505 218493001846 psiF repeat; Region: PsiF_repeat; pfam07769 218493001847 psiF repeat; Region: PsiF_repeat; pfam07769 218493001848 1 probable transmembrane helix predicted for SBG0340 by TMHMM2.0 at aa 5-22 218493001851 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 218493001852 MASE2 domain; Region: MASE2; pfam05230 218493001853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493001854 metal binding site [ion binding]; metal-binding site 218493001855 active site 218493001856 I-site; other site 218493001858 5 probable transmembrane helices predicted for SBG0341 by TMHMM2.0 at aa 40-62, 67-84, 105-127, 142-164 and 171-193 218493001861 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 218493001862 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 218493001865 hypothetical protein; Validated; Region: PRK00124 218493001867 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 218493001868 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218493001869 ADP binding site [chemical binding]; other site 218493001870 magnesium binding site [ion binding]; other site 218493001871 putative shikimate binding site; other site 218493001875 hypothetical protein; Provisional; Region: PRK10380 218493001876 hypothetical protein; Provisional; Region: PRK10481 218493001878 hypothetical protein; Provisional; Region: PRK10579 218493001880 recombination associated protein; Reviewed; Region: rdgC; PRK00321 218493001882 fructokinase; Reviewed; Region: PRK09557 218493001883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493001884 nucleotide binding site [chemical binding]; other site 218493001888 MFS transport protein AraJ; Provisional; Region: PRK10091 218493001889 signal peptide predicted for SBG0350 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.535 between residues 30 and 31 218493001890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493001891 putative substrate translocation pore; other site 218493001892 12 probable transmembrane helices predicted for SBG0350 by TMHMM2.0 at aa 4-26, 33-55, 70-92, 99-117,127-149, 156-178, 198-220, 227-249, 264-286, 293-315,330-352 and 354-376 218493001895 exonuclease subunit SbcC; Provisional; Region: PRK10246 218493001896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493001897 Walker A/P-loop; other site 218493001898 ATP binding site [chemical binding]; other site 218493001899 Q-loop/lid; other site 218493001900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493001901 ABC transporter signature motif; other site 218493001902 Walker B; other site 218493001903 D-loop; other site 218493001904 H-loop/switch region; other site 218493001909 exonuclease subunit SbcD; Provisional; Region: PRK10966 218493001910 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 218493001911 active site 218493001912 metal binding site [ion binding]; metal-binding site 218493001913 DNA binding site [nucleotide binding] 218493001914 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 218493001916 transcriptional regulator PhoB; Provisional; Region: PRK10161 218493001917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493001918 active site 218493001919 phosphorylation site [posttranslational modification] 218493001920 intermolecular recognition site; other site 218493001921 dimerization interface [polypeptide binding]; other site 218493001922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493001923 DNA binding site [nucleotide binding] 218493001926 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 218493001927 signal peptide predicted for SBG0354 by SignalP 2.0 HMM (Signal peptide probabilty 0.885) with cleavage site probability 0.759 between residues 37 and 38 218493001928 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 218493001929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493001930 putative active site [active] 218493001931 heme pocket [chemical binding]; other site 218493001932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493001933 dimer interface [polypeptide binding]; other site 218493001934 phosphorylation site [posttranslational modification] 218493001935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493001936 ATP binding site [chemical binding]; other site 218493001937 Mg2+ binding site [ion binding]; other site 218493001938 G-X-G motif; other site 218493001939 1 probable transmembrane helix predicted for SBG0354 by TMHMM2.0 at aa 12-34 218493001943 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 218493001944 signal peptide predicted for SBG0355 by SignalP 2.0 HMM (Signal peptide probabilty 0.884) with cleavage site probability 0.712 between residues 24 and 25 218493001946 12 probable transmembrane helices predicted for SBG0355 by TMHMM2.0 at aa 13-35, 41-63, 76-98,118-140, 147-169, 189-211, 223-245, 276-298, 305-327,337-359, 371-393 and 408-426 218493001949 putative proline-specific permease; Provisional; Region: proY; PRK10580 218493001950 signal peptide predicted for SBG0356 by SignalP 2.0 HMM (Signal peptide probabilty 0.953) with cleavage site probability 0.341 between residues 36 and 37 218493001952 12 probable transmembrane helices predicted for SBG0356 by TMHMM2.0 at aa 16-34, 44-63, 83-105,120-142, 154-176, 196-218, 239-261, 276-298, 329-351,356-378, 399-421 and 426-445 218493001954 maltodextrin glucosidase; Provisional; Region: PRK10785 218493001955 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 218493001956 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 218493001957 active site 218493001958 homodimer interface [polypeptide binding]; other site 218493001959 catalytic site [active] 218493001961 peroxidase; Provisional; Region: PRK15000 218493001962 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 218493001963 dimer interface [polypeptide binding]; other site 218493001964 decamer (pentamer of dimers) interface [polypeptide binding]; other site 218493001965 catalytic triad [active] 218493001966 peroxidatic and resolving cysteines [active] 218493001968 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 218493001970 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 218493001971 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 218493001973 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 218493001974 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 218493001976 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 218493001978 1 probable transmembrane helix predicted for SBG0362 by TMHMM2.0 at aa 20-39 218493001979 signal peptide predicted for SBG0363 by SignalP 2.0 HMM (Signal peptide probabilty 0.878) with cleavage site probability 0.506 between residues 30 and 31 218493001980 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 218493001981 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 218493001982 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 218493001983 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 218493001984 6 probable transmembrane helices predicted for SBG0363 by TMHMM2.0 at aa 7-29, 452-470, 475-497, 502-524,548-570 and 580-602 218493001988 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 218493001989 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 218493001990 Protein export membrane protein; Region: SecD_SecF; pfam02355 218493001991 6 probable transmembrane helices predicted for SBG0364 by TMHMM2.0 at aa 24-46, 143-162, 169-191,195-217, 248-270 and 275-297 218493001994 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 218493001995 active site 218493001998 signal peptide predicted for SBG0366 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23 218493001999 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 218493002001 hypothetical protein; Provisional; Region: PRK11530 218493002002 signal peptide predicted for SBG0367 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.383 between residues 24 and 25 218493002004 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 218493002005 ATP cone domain; Region: ATP-cone; pfam03477 218493002007 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 218493002008 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 218493002009 catalytic motif [active] 218493002010 Zn binding site [ion binding]; other site 218493002011 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 218493002015 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 218493002016 homopentamer interface [polypeptide binding]; other site 218493002017 active site 218493002019 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 218493002020 putative RNA binding site [nucleotide binding]; other site 218493002022 thiamine monophosphate kinase; Provisional; Region: PRK05731 218493002023 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 218493002024 ATP binding site [chemical binding]; other site 218493002025 dimerization interface [polypeptide binding]; other site 218493002027 signal peptide predicted for SBG0373 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.446 between residues 44 and 45 218493002028 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 218493002029 tetramer interfaces [polypeptide binding]; other site 218493002030 binuclear metal-binding site [ion binding]; other site 218493002031 3 probable transmembrane helices predicted for SBG0373 by TMHMM2.0 at aa 21-43, 53-75 and 149-168 218493002033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493002034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493002035 active site 218493002036 catalytic tetrad [active] 218493002038 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 218493002039 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 218493002040 TPP-binding site; other site 218493002041 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218493002042 PYR/PP interface [polypeptide binding]; other site 218493002043 dimer interface [polypeptide binding]; other site 218493002044 TPP binding site [chemical binding]; other site 218493002045 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218493002050 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218493002051 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218493002052 substrate binding pocket [chemical binding]; other site 218493002053 chain length determination region; other site 218493002054 substrate-Mg2+ binding site; other site 218493002055 catalytic residues [active] 218493002056 aspartate-rich region 1; other site 218493002057 active site lid residues [active] 218493002058 aspartate-rich region 2; other site 218493002063 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 218493002065 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 218493002066 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 218493002067 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 218493002068 Ligand Binding Site [chemical binding]; other site 218493002069 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218493002070 active site residue [active] 218493002073 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 218493002074 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 218493002075 conserved cys residue [active] 218493002077 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 218493002078 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 218493002079 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 218493002082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 218493002083 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 218493002085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493002086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493002087 putative substrate translocation pore; other site 218493002088 12 probable transmembrane helices predicted for SBG0382 by TMHMM2.0 at aa 13-35, 50-72, 79-98,102-124, 137-159, 164-186, 214-236, 251-273, 280-302,306-328, 341-363 and 368-385 218493002091 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 218493002092 UbiA prenyltransferase family; Region: UbiA; pfam01040 218493002093 9 probable transmembrane helices predicted for SBG0384 by TMHMM2.0 at aa 12-34, 38-60, 81-103, 108-127,134-156, 161-183, 209-231, 235-252 and 264-286 218493002098 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 218493002099 3 probable transmembrane helices predicted for SBG0385 by TMHMM2.0 at aa 21-40, 44-66 and 78-100 218493002101 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 218493002102 Subunit I/III interface [polypeptide binding]; other site 218493002103 Subunit III/IV interface [polypeptide binding]; other site 218493002105 5 probable transmembrane helices predicted for SBG0386 by TMHMM2.0 at aa 29-51, 66-88, 101-123, 138-160 and 181-203 218493002106 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 218493002107 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 218493002108 D-pathway; other site 218493002109 Putative ubiquinol binding site [chemical binding]; other site 218493002110 Low-spin heme (heme b) binding site [chemical binding]; other site 218493002111 Putative water exit pathway; other site 218493002112 Binuclear center (heme o3/CuB) [ion binding]; other site 218493002113 K-pathway; other site 218493002114 Putative proton exit pathway; other site 218493002115 14 probable transmembrane helices predicted for SBG0387 by TMHMM2.0 at aa 15-37, 57-79, 105-127,140-162, 191-213, 233-255, 275-297, 310-332, 347-369,382-404, 414-436, 456-478, 498-520 and 590-612 218493002119 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 218493002120 signal peptide predicted for SBG0388 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.645 between residues 30 and 31 218493002121 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 218493002122 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 218493002125 3 probable transmembrane helices predicted for SBG0388 by TMHMM2.0 at aa 12-30, 45-67 and 88-110 218493002127 signal peptide predicted for SBG0389 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.595 between residues 37 and 38 218493002128 muropeptide transporter; Reviewed; Region: ampG; PRK11902 218493002129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493002130 putative substrate translocation pore; other site 218493002131 14 probable transmembrane helices predicted for SBG0389 by TMHMM2.0 at aa 13-35, 50-69, 82-104,109-131, 144-166, 176-195, 223-245, 260-282, 287-309,319-341, 354-376, 381-403, 424-446 and 466-485 218493002133 hypothetical protein; Provisional; Region: PRK11627 218493002134 signal peptide predicted for SBG0390 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.734 between residues 19 and 20 218493002135 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 218493002138 transcriptional regulator BolA; Provisional; Region: PRK11628 218493002140 trigger factor; Provisional; Region: tig; PRK01490 218493002141 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218493002142 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 218493002146 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 218493002147 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218493002148 oligomer interface [polypeptide binding]; other site 218493002149 active site residues [active] 218493002153 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 218493002154 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 218493002155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493002156 Walker A motif; other site 218493002157 ATP binding site [chemical binding]; other site 218493002158 Walker B motif; other site 218493002159 Iron permease FTR1 family; Region: FTR1; cl00475 218493002160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 218493002164 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 218493002165 Found in ATP-dependent protease La (LON); Region: LON; smart00464 218493002166 Found in ATP-dependent protease La (LON); Region: LON; smart00464 218493002167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493002168 Walker A motif; other site 218493002169 ATP binding site [chemical binding]; other site 218493002170 Walker B motif; other site 218493002171 arginine finger; other site 218493002172 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218493002180 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218493002181 IHF dimer interface [polypeptide binding]; other site 218493002182 IHF - DNA interface [nucleotide binding]; other site 218493002185 periplasmic folding chaperone; Provisional; Region: PRK10788 218493002186 SurA N-terminal domain; Region: SurA_N_3; cl07813 218493002187 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 218493002188 1 probable transmembrane helix predicted for SBG0397 by TMHMM2.0 at aa 13-35 218493002192 signal peptide predicted for SBG0398 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 25 and 26 218493002193 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 218493002194 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218493002195 active site 218493002197 signal peptide predicted for SBG0400 by SignalP 2.0 HMM (Signal peptide probabilty 0.739) with cleavage site probability 0.738 between residues 19 and 20 218493002198 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 218493002199 Ligand Binding Site [chemical binding]; other site 218493002201 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 218493002202 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 218493002203 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 218493002205 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 218493002206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493002207 active site 218493002208 motif I; other site 218493002209 motif II; other site 218493002213 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218493002214 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 218493002215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218493002216 catalytic residue [active] 218493002218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 218493002219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493002220 putative DNA binding site [nucleotide binding]; other site 218493002221 putative Zn2+ binding site [ion binding]; other site 218493002222 AsnC family; Region: AsnC_trans_reg; pfam01037 218493002225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493002226 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 218493002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493002228 Walker A/P-loop; other site 218493002229 ATP binding site [chemical binding]; other site 218493002230 Q-loop/lid; other site 218493002231 ABC transporter signature motif; other site 218493002232 Walker B; other site 218493002233 D-loop; other site 218493002234 H-loop/switch region; other site 218493002236 6 probable transmembrane helices predicted for SBG0405 by TMHMM2.0 at aa 21-43, 53-75, 129-151, 156-175,246-268 and 278-300 218493002240 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 218493002241 signal peptide predicted for SBG0406 by SignalP 2.0 HMM (Signal peptide probabilty 0.941) with cleavage site probability 0.648 between residues 37 and 38 218493002242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493002243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493002244 Walker A/P-loop; other site 218493002245 ATP binding site [chemical binding]; other site 218493002246 Q-loop/lid; other site 218493002247 ABC transporter signature motif; other site 218493002248 Walker B; other site 218493002249 D-loop; other site 218493002250 H-loop/switch region; other site 218493002252 5 probable transmembrane helices predicted for SBG0406 by TMHMM2.0 at aa 27-49, 64-83, 138-160, 165-185 and 249-271 218493002256 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 218493002257 Nitrogen regulatory protein P-II; Region: P-II; smart00938 218493002261 ammonium transporter; Provisional; Region: PRK10666 218493002262 signal peptide predicted for SBG0409 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 27 and 28 218493002263 12 probable transmembrane helices predicted for SBG0409 by TMHMM2.0 at aa 9-26, 36-58, 63-85, 120-142,149-171, 186-205, 218-237, 247-269, 281-303, 307-324,337-359 and 374-396 218493002269 acyl-CoA thioesterase II; Provisional; Region: PRK10526 218493002270 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 218493002271 active site 218493002272 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 218493002273 catalytic triad [active] 218493002274 dimer interface [polypeptide binding]; other site 218493002277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 218493002278 signal peptide predicted for SBG0411 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.693 between residues 20 and 21 218493002280 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 218493002281 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218493002282 DNA binding site [nucleotide binding] 218493002283 active site 218493002285 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 218493002286 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218493002287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493002289 2 probable transmembrane helices predicted for SBG0413 by TMHMM2.0 at aa 7-29 and 243-265 218493002290 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 218493002292 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 218493002293 2 probable transmembrane helices predicted for SBG0415 by TMHMM2.0 at aa 36-55 and 60-79 218493002294 maltose O-acetyltransferase; Provisional; Region: PRK10092 218493002295 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 218493002296 active site 218493002297 substrate binding site [chemical binding]; other site 218493002298 trimer interface [polypeptide binding]; other site 218493002299 CoA binding site [chemical binding]; other site 218493002304 gene expression modulator; Provisional; Region: PRK10945 218493002306 Hha toxicity attenuator; Provisional; Region: PRK10667 218493002307 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 218493002308 Protein export membrane protein; Region: SecD_SecF; cl14618 218493002309 Protein export membrane protein; Region: SecD_SecF; cl14618 218493002311 11 probable transmembrane helices predicted for SBG0419 by TMHMM2.0 at aa 10-32, 340-359, 369-391,438-460, 470-492, 542-564, 873-892, 899-921, 926-948,975-997 and 1007-1029 218493002313 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 218493002314 signal peptide predicted for SBG0420 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.586 between residues 24 and 25 218493002315 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493002318 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 218493002319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493002320 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 218493002324 signal peptide predicted for SBG0422 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.892 between residues 33 and 34 218493002325 hypothetical protein; Provisional; Region: PRK11281 218493002326 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 218493002327 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 218493002328 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493002329 10 probable transmembrane helices predicted for SBG0422 by TMHMM2.0 at aa 13-32, 500-522, 557-579,658-680, 693-715, 725-747, 795-817, 837-859, 880-902 and 917-939 218493002335 hypothetical protein; Provisional; Region: PRK11038 218493002336 primosomal replication protein N''; Provisional; Region: PRK10093 218493002338 signal peptide predicted for SBG0427 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.644 between residues 33 and 34 218493002339 1 probable transmembrane helix predicted for SBG0427 by TMHMM2.0 at aa 5-27 218493002340 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493002341 active site 218493002344 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 218493002345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493002346 Walker A motif; other site 218493002347 ATP binding site [chemical binding]; other site 218493002348 Walker B motif; other site 218493002349 DNA polymerase III subunit delta'; Validated; Region: PRK08485 218493002350 arginine finger; other site 218493002351 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 218493002352 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 218493002353 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 218493002356 hypothetical protein; Validated; Region: PRK00153 218493002358 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 218493002359 RecR protein; Region: RecR; pfam02132 218493002360 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 218493002361 putative active site [active] 218493002362 putative metal-binding site [ion binding]; other site 218493002363 tetramer interface [polypeptide binding]; other site 218493002367 heat shock protein 90; Provisional; Region: PRK05218 218493002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493002369 ATP binding site [chemical binding]; other site 218493002370 Mg2+ binding site [ion binding]; other site 218493002371 G-X-G motif; other site 218493002375 adenylate kinase; Reviewed; Region: adk; PRK00279 218493002376 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 218493002377 AMP-binding site [chemical binding]; other site 218493002378 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 218493002382 ferrochelatase; Reviewed; Region: hemH; PRK00035 218493002383 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 218493002384 C-terminal domain interface [polypeptide binding]; other site 218493002385 active site 218493002386 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 218493002387 active site 218493002388 N-terminal domain interface [polypeptide binding]; other site 218493002391 acetyl esterase; Provisional; Region: PRK10162 218493002392 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 218493002395 inosine/guanosine kinase; Provisional; Region: PRK15074 218493002396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493002399 putative cation:proton antiport protein; Provisional; Region: PRK10669 218493002400 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 218493002401 TrkA-N domain; Region: TrkA_N; pfam02254 218493002403 12 probable transmembrane helices predicted for SBG0438 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109,114-136, 149-171, 186-208, 229-251, 280-299, 306-328,333-355 and 368-387 218493002406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493002407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493002408 putative substrate translocation pore; other site 218493002409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493002410 10 probable transmembrane helices predicted for SBG0439 by TMHMM2.0 at aa 26-48, 58-80, 101-123,180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399 218493002412 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 218493002413 signal peptide predicted for SBG0440 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 25 and 26 218493002414 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 218493002415 active site 218493002416 metal binding site [ion binding]; metal-binding site 218493002417 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218493002422 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 218493002423 putative deacylase active site [active] 218493002425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 218493002427 copper exporting ATPase; Provisional; Region: copA; PRK10671 218493002428 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218493002429 metal-binding site [ion binding] 218493002430 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218493002431 metal-binding site [ion binding] 218493002432 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493002433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493002434 motif II; other site 218493002435 8 probable transmembrane helices predicted for SBG0443 by TMHMM2.0 at aa 188-205, 215-237, 244-266,281-298, 435-457, 462-484, 777-796 and 801-823 218493002446 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 218493002447 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 218493002448 DNA binding residues [nucleotide binding] 218493002449 dimer interface [polypeptide binding]; other site 218493002450 copper binding site [ion binding]; other site 218493002454 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 218493002456 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 218493002457 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 218493002460 1 probable transmembrane helix predicted for SBG0445 by TMHMM2.0 at aa 7-29 218493002461 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 218493002462 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 218493002463 Walker A/P-loop; other site 218493002464 ATP binding site [chemical binding]; other site 218493002465 Q-loop/lid; other site 218493002466 ABC transporter signature motif; other site 218493002467 Walker B; other site 218493002468 D-loop; other site 218493002469 H-loop/switch region; other site 218493002473 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 218493002474 signal peptide predicted for SBG0447 by SignalP 2.0 HMM (Signal peptide probabilty 0.939) with cleavage site probability 0.469 between residues 27 and 28 218493002476 7 probable transmembrane helices predicted for SBG0447 by TMHMM2.0 at aa 5-24, 36-53, 57-79, 92-114,118-140, 192-209 and 219-241 218493002478 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 218493002479 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 218493002481 oxidoreductase; Provisional; Region: PRK08017 218493002482 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 218493002483 NADP binding site [chemical binding]; other site 218493002484 active site 218493002485 steroid binding site; other site 218493002488 signal peptide predicted for SBG0450 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.766 between residues 25 and 26 218493002489 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 218493002490 active site 218493002491 catalytic triad [active] 218493002492 oxyanion hole [active] 218493002493 switch loop; other site 218493002496 1 probable transmembrane helix predicted for SBG0450 by TMHMM2.0 at aa 7-26 218493002497 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 218493002498 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218493002499 Walker A/P-loop; other site 218493002500 ATP binding site [chemical binding]; other site 218493002501 Q-loop/lid; other site 218493002502 ABC transporter signature motif; other site 218493002503 Walker B; other site 218493002504 D-loop; other site 218493002505 H-loop/switch region; other site 218493002509 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 218493002510 signal peptide predicted for SBG0452 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.531 between residues 33 and 34 218493002511 FtsX-like permease family; Region: FtsX; pfam02687 218493002512 FtsX-like permease family; Region: FtsX; pfam02687 218493002513 10 probable transmembrane helices predicted for SBG0452 by TMHMM2.0 at aa 13-35, 243-262, 291-313,338-360, 381-403, 407-429, 450-472, 676-698, 732-754 and 769-791 218493002517 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 218493002518 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 218493002519 active site residue [active] 218493002521 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 218493002522 ATP-grasp domain; Region: ATP-grasp; pfam02222 218493002524 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 218493002526 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 218493002527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218493002528 putative active site [active] 218493002529 putative metal binding site [ion binding]; other site 218493002531 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 218493002532 substrate binding site [chemical binding]; other site 218493002535 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 218493002536 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218493002537 active site 218493002538 HIGH motif; other site 218493002539 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218493002540 KMSKS motif; other site 218493002541 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 218493002542 tRNA binding surface [nucleotide binding]; other site 218493002543 anticodon binding site; other site 218493002546 ribosome-associated protein; Provisional; Region: PRK11507 218493002547 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 218493002548 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 218493002549 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 218493002550 homodimer interface [polypeptide binding]; other site 218493002551 NADP binding site [chemical binding]; other site 218493002552 substrate binding site [chemical binding]; other site 218493002559 fim fimbrial operon remnant 218493002560 SB52 prophage remnant 218493002562 Transposase; Region: HTH_Tnp_1; pfam01527 218493002564 putative transposase OrfB; Reviewed; Region: PHA02517 218493002565 HTH-like domain; Region: HTH_21; pfam13276 218493002566 Integrase core domain; Region: rve; pfam00665 218493002567 Integrase core domain; Region: rve_3; pfam13683 218493002570 signal peptide predicted for SBG0466 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.934 between residues 25 and 26 218493002571 10 probable transmembrane helices predicted for SBG0466 by TMHMM2.0 at aa 2-19, 23-40, 47-69, 79-101,114-136, 160-182, 195-217, 221-238, 305-327 and 342-361 218493002574 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 218493002576 10 probable transmembrane helices predicted for SBG0469 by TMHMM2.0 at aa 7-26, 36-58, 79-97, 132-151,158-180, 195-217, 224-243, 248-270, 283-305 and 320-339 218493002577 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 218493002578 DNA-binding interface [nucleotide binding]; DNA binding site 218493002580 possible site for programmed ribosomal frameshifting 218493002581 no suitable translational start site but there is a poly A tract that could offer a region for programmed ribosomal frameshifting 218493002582 Cupin; Region: Cupin_6; pfam12852 218493002583 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218493002584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493002585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493002589 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 218493002590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493002591 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218493002597 signal peptide predicted for SBG0474 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.698 between residues 22 and 23 218493002598 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493002600 Predicted membrane protein [Function unknown]; Region: COG3059 218493002602 3 probable transmembrane helices predicted for SBG0475 by TMHMM2.0 at aa 15-37, 87-106 and 111-133 218493002603 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 218493002604 phenylalanine transporter; Provisional; Region: PRK10249 218493002606 12 probable transmembrane helices predicted for SBG0477 by TMHMM2.0 at aa 34-53, 57-74, 102-124,139-161, 166-188, 210-232, 253-275, 295-317, 344-366,370-392, 413-435 and 440-459 218493002608 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 218493002609 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493002611 4 probable transmembrane helices predicted for SBG0478 by TMHMM2.0 at aa 23-45, 97-119, 139-161 and 166-183 218493002612 signal peptide predicted for SBG0479 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.903 between residues 25 and 26 218493002613 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 218493002614 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 218493002615 active site 218493002616 oxyanion hole [active] 218493002617 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 218493002618 catalytic triad [active] 218493002619 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 218493002623 signal peptide predicted for SBG0480 by SignalP 2.0 HMM (Signal peptide probabilty 0.889) with cleavage site probability 0.530 between residues 33 and 34 218493002624 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 218493002625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493002626 ATP binding site [chemical binding]; other site 218493002627 Walker B motif; other site 218493002628 arginine finger; other site 218493002629 Transcriptional antiterminator [Transcription]; Region: COG3933 218493002630 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493002631 active pocket/dimerization site; other site 218493002632 active site 218493002633 phosphorylation site [posttranslational modification] 218493002634 PRD domain; Region: PRD; pfam00874 218493002639 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 218493002640 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 218493002641 putative active site [active] 218493002642 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218493002643 dimer interface [polypeptide binding]; other site 218493002644 active site 218493002648 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 218493002649 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218493002650 dimer interface [polypeptide binding]; other site 218493002651 active site 218493002652 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 218493002654 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 218493002656 4 probable transmembrane helices predicted for SBG0483 by TMHMM2.0 at aa 152-174, 195-217, 237-254 and 261-283 218493002657 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 218493002658 7 probable transmembrane helices predicted for SBG0484 by TMHMM2.0 at aa 5-27, 47-69, 92-114, 134-156,161-183, 190-212 and 222-241 218493002660 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218493002661 active site 218493002662 phosphorylation site [posttranslational modification] 218493002664 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493002665 active site 218493002666 active pocket/dimerization site; other site 218493002667 phosphorylation site [posttranslational modification] 218493002669 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 218493002670 dimer interface [polypeptide binding]; other site 218493002671 FMN binding site [chemical binding]; other site 218493002673 hypothetical protein; Provisional; Region: PRK10250 218493002675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218493002676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493002679 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 218493002680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493002684 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 218493002685 signal peptide predicted for SBG0490 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.840 between residues 35 and 36 218493002687 2 probable transmembrane helices predicted for SBG0490 by TMHMM2.0 at aa 13-35 and 50-72 218493002688 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 218493002689 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 218493002691 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 218493002692 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 218493002694 outer membrane receptor FepA; Provisional; Region: PRK13524 218493002695 signal peptide predicted for SBG0493 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 25 and 26 218493002696 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493002697 N-terminal plug; other site 218493002698 ligand-binding site [chemical binding]; other site 218493002704 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 218493002705 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 218493002706 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 218493002708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 218493002710 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 218493002711 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218493002712 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218493002713 acyl-activating enzyme (AAE) consensus motif; other site 218493002714 AMP binding site [chemical binding]; other site 218493002715 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218493002722 LPS O-antigen length regulator; Provisional; Region: PRK10381 218493002723 Chain length determinant protein; Region: Wzz; pfam02706 218493002724 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 218493002726 2 probable transmembrane helices predicted for SBG0497 by TMHMM2.0 at aa 43-62 and 339-358 218493002728 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 218493002729 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218493002730 Walker A/P-loop; other site 218493002731 ATP binding site [chemical binding]; other site 218493002732 Q-loop/lid; other site 218493002733 ABC transporter signature motif; other site 218493002734 Walker B; other site 218493002735 D-loop; other site 218493002736 H-loop/switch region; other site 218493002740 signal peptide predicted for SBG0499 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.878 between residues 30 and 31 218493002741 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 218493002742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493002743 ABC-ATPase subunit interface; other site 218493002744 dimer interface [polypeptide binding]; other site 218493002745 putative PBP binding regions; other site 218493002747 8 probable transmembrane helices predicted for SBG0499 by TMHMM2.0 at aa 7-26, 57-79, 92-111, 115-137,144-166, 193-210, 239-261 and 301-323 218493002749 signal peptide predicted for SBG0500 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.809 between residues 32 and 33 218493002750 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218493002751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493002752 ABC-ATPase subunit interface; other site 218493002753 dimer interface [polypeptide binding]; other site 218493002754 putative PBP binding regions; other site 218493002756 9 probable transmembrane helices predicted for SBG0500 by TMHMM2.0 at aa 10-32, 65-82, 92-114, 121-140,155-177, 198-220, 240-262, 282-304 and 308-326 218493002757 enterobactin exporter EntS; Provisional; Region: PRK10489 218493002758 signal peptide predicted for SBG0501 by SignalP 2.0 HMM (Signal peptide probabilty 0.816) with cleavage site probability 0.720 between residues 20 and 21 218493002759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493002760 putative substrate translocation pore; other site 218493002761 12 probable transmembrane helices predicted for SBG0501 by TMHMM2.0 at aa 22-44, 54-76, 85-106,121-140, 153-175, 179-201, 214-236, 256-278, 285-307,312-331, 352-374 and 379-398 218493002763 signal peptide predicted for SBG0502 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.940 between residues 24 and 25 218493002764 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 218493002765 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 218493002766 siderophore binding site; other site 218493002768 1 probable transmembrane helix predicted for SBG0502 by TMHMM2.0 at aa 7-29 218493002769 isochorismate synthase EntC; Provisional; Region: PRK15016 218493002770 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 218493002772 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 218493002773 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 218493002774 acyl-activating enzyme (AAE) consensus motif; other site 218493002775 active site 218493002776 AMP binding site [chemical binding]; other site 218493002777 substrate binding site [chemical binding]; other site 218493002780 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 218493002781 hydrophobic substrate binding pocket; other site 218493002782 Isochorismatase family; Region: Isochorismatase; pfam00857 218493002783 active site 218493002784 conserved cis-peptide bond; other site 218493002785 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 218493002788 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 218493002789 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 218493002790 putative NAD(P) binding site [chemical binding]; other site 218493002791 active site 218493002794 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218493002795 CoenzymeA binding site [chemical binding]; other site 218493002796 subunit interaction site [polypeptide binding]; other site 218493002797 PHB binding site; other site 218493002799 carbon starvation protein A; Provisional; Region: PRK15015 218493002800 signal peptide predicted for SBG0508 by SignalP 2.0 HMM (Signal peptide probabilty 0.957) with cleavage site probability 0.519 between residues 22 and 23 218493002801 Carbon starvation protein CstA; Region: CstA; pfam02554 218493002802 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 218493002803 18 probable transmembrane helices predicted for SBG0508 by TMHMM2.0 at aa 7-26, 32-54, 89-111,116-138, 159-181, 191-213, 218-240, 255-277, 284-306,326-348, 361-383, 398-420, 441-463, 468-487, 514-533,548-570, 577-599 and 649-671 218493002808 Uncharacterized small protein [Function unknown]; Region: COG2879 218493002810 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 218493002811 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 218493002812 putative active site [active] 218493002813 metal binding site [ion binding]; metal-binding site 218493002816 1 probable transmembrane helix predicted for SBG0510 by TMHMM2.0 at aa 111-133 218493002817 methionine aminotransferase; Validated; Region: PRK09082 218493002818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493002819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493002820 homodimer interface [polypeptide binding]; other site 218493002821 catalytic residue [active] 218493002824 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 218493002825 ParB-like nuclease domain; Region: ParBc; pfam02195 218493002827 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 218493002828 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218493002829 Active Sites [active] 218493002830 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 218493002832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493002833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493002834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493002835 dimerization interface [polypeptide binding]; other site 218493002839 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 218493002840 signal peptide predicted for SBG0516 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 17 and 18 218493002841 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 218493002842 dimerization domain [polypeptide binding]; other site 218493002843 dimer interface [polypeptide binding]; other site 218493002844 catalytic residues [active] 218493002845 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 218493002846 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 218493002847 dimer interface [polypeptide binding]; other site 218493002848 decamer (pentamer of dimers) interface [polypeptide binding]; other site 218493002849 catalytic triad [active] 218493002850 peroxidatic and resolving cysteines [active] 218493002852 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 218493002853 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 218493002854 catalytic residue [active] 218493002855 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 218493002856 catalytic residues [active] 218493002857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493002858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493002863 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 218493002865 signal peptide predicted for SBG0519 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.989 between residues 38 and 39 218493002866 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 218493002867 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 218493002868 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 218493002869 putative [4Fe-4S] binding site [ion binding]; other site 218493002870 putative molybdopterin cofactor binding site [chemical binding]; other site 218493002871 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 218493002872 molybdopterin cofactor binding site; other site 218493002876 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 218493002877 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218493002881 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 218493002883 8 probable transmembrane helices predicted for SBG0521 by TMHMM2.0 at aa 5-27, 39-61, 76-95, 102-124,134-156, 163-185, 195-215 and 222-241 218493002885 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493002886 Ligand Binding Site [chemical binding]; other site 218493002888 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 218493002889 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493002890 NAD binding site [chemical binding]; other site 218493002891 catalytic Zn binding site [ion binding]; other site 218493002892 structural Zn binding site [ion binding]; other site 218493002897 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 218493002898 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218493002900 signal peptide predicted for SBG0525 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.974 between residues 23 and 24 218493002901 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 218493002902 B1 nucleotide binding pocket [chemical binding]; other site 218493002903 B2 nucleotide binding pocket [chemical binding]; other site 218493002904 CAS motifs; other site 218493002905 active site 218493002909 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493002910 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218493002911 transmembrane helices; other site 218493002913 13 probable transmembrane helices predicted for SBG0526 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117,138-157, 198-220, 233-255, 288-305, 307-329, 339-361,374-396, 428-450 and 463-485 218493002916 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 218493002918 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 218493002921 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 218493002922 Coenzyme A transferase; Region: CoA_trans; cl17247 218493002923 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 218493002926 signal peptide predicted for SBG0530 by SignalP 2.0 HMM (Signal peptide probabilty 0.859) with cleavage site probability 0.262 between residues 25 and 26 218493002927 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 218493002929 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 218493002931 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 218493002932 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 218493002933 putative active site [active] 218493002934 (T/H)XGH motif; other site 218493002937 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 218493002938 signal peptide predicted for SBG0533 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.936 between residues 38 and 39 218493002939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493002940 putative active site [active] 218493002941 heme pocket [chemical binding]; other site 218493002942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493002943 ATP binding site [chemical binding]; other site 218493002944 Mg2+ binding site [ion binding]; other site 218493002945 G-X-G motif; other site 218493002946 2 probable transmembrane helices predicted for SBG0533 by TMHMM2.0 at aa 20-42 and 179-201 218493002949 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 218493002950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493002951 active site 218493002952 phosphorylation site [posttranslational modification] 218493002953 intermolecular recognition site; other site 218493002954 dimerization interface [polypeptide binding]; other site 218493002955 Transcriptional regulator; Region: CitT; pfam12431 218493002957 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 218493002958 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 218493002959 11 probable transmembrane helices predicted for SBG0535 by TMHMM2.0 at aa 13-35, 70-92, 113-135,150-172, 185-207, 227-249, 256-278, 298-320, 332-354,396-418 and 425-447 218493002961 signal peptide predicted for SBG0536 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.993 between residues 29 and 30 218493002962 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 218493002963 1 probable transmembrane helix predicted for SBG0536 by TMHMM2.0 at aa 13-30 218493002965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493002966 DNA-binding site [nucleotide binding]; DNA binding site 218493002967 RNA-binding motif; other site 218493002970 chromosome condensation membrane protein; Provisional; Region: PRK14196 218493002971 4 probable transmembrane helices predicted for SBG0538 by TMHMM2.0 at aa 5-22, 32-54, 67-89 and 99-121 218493002973 Predicted amidohydrolase [General function prediction only]; Region: COG0388 218493002974 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 218493002975 putative active site [active] 218493002976 catalytic triad [active] 218493002977 putative dimer interface [polypeptide binding]; other site 218493002980 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 218493002982 1 probable transmembrane helix predicted for SBG0540 by TMHMM2.0 at aa 4-21 218493002983 lipoyl synthase; Provisional; Region: PRK05481 218493002984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493002985 FeS/SAM binding site; other site 218493002987 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 218493002988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493002989 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 218493002990 substrate binding pocket [chemical binding]; other site 218493002991 dimerization interface [polypeptide binding]; other site 218493002995 lipoate-protein ligase B; Provisional; Region: PRK14342 218493002998 hypothetical protein; Provisional; Region: PRK04998 218493003000 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 218493003001 signal peptide predicted for SBG0545 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 29 and 30 218493003002 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218493003003 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 218493003006 rare lipoprotein A; Provisional; Region: PRK10672 218493003007 signal peptide predicted for SBG0546 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.715 between residues 25 and 26 218493003008 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 218493003009 Sporulation related domain; Region: SPOR; pfam05036 218493003013 cell wall shape-determining protein; Provisional; Region: PRK10794 218493003014 signal peptide predicted for SBG0547 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.583 between residues 40 and 41 218493003016 9 probable transmembrane helices predicted for SBG0547 by TMHMM2.0 at aa 15-37, 50-68, 73-95, 136-155,160-179, 181-203, 272-294, 306-328 and 338-360 218493003018 penicillin-binding protein 2; Provisional; Region: PRK10795 218493003019 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218493003020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218493003023 1 probable transmembrane helix predicted for SBG0548 by TMHMM2.0 at aa 21-43 218493003024 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 218493003026 ribosome-associated protein; Provisional; Region: PRK11538 218493003030 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 218493003031 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 218493003032 active site 218493003033 (T/H)XGH motif; other site 218493003035 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 218493003036 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 218493003038 signal peptide predicted for SBG0554 by SignalP 2.0 HMM (Signal peptide probabilty 0.819) with cleavage site probability 0.186 between residues 31 and 32 218493003039 Lipopolysaccharide-assembly; Region: LptE; cl01125 218493003042 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 218493003043 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 218493003044 HIGH motif; other site 218493003045 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218493003046 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218493003047 active site 218493003048 KMSKS motif; other site 218493003049 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 218493003050 tRNA binding surface [nucleotide binding]; other site 218493003054 hypothetical protein; Provisional; Region: PRK11032 218493003055 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 218493003057 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 218493003058 active site 218493003059 tetramer interface [polypeptide binding]; other site 218493003062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218493003063 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218493003064 Walker A/P-loop; other site 218493003065 ATP binding site [chemical binding]; other site 218493003066 Q-loop/lid; other site 218493003067 ABC transporter signature motif; other site 218493003068 Walker B; other site 218493003069 D-loop; other site 218493003070 H-loop/switch region; other site 218493003074 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493003075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493003076 dimer interface [polypeptide binding]; other site 218493003077 conserved gate region; other site 218493003078 putative PBP binding loops; other site 218493003079 ABC-ATPase subunit interface; other site 218493003081 5 probable transmembrane helices predicted for SBG0560 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 218493003082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493003084 dimer interface [polypeptide binding]; other site 218493003085 conserved gate region; other site 218493003086 putative PBP binding loops; other site 218493003087 ABC-ATPase subunit interface; other site 218493003089 5 probable transmembrane helices predicted for SBG0561 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233 218493003090 signal peptide predicted for SBG0562 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 28 and 29 218493003091 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 218493003092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493003093 substrate binding pocket [chemical binding]; other site 218493003094 membrane-bound complex binding site; other site 218493003095 hinge residues; other site 218493003097 signal peptide predicted for SBG0564 by SignalP 2.0 HMM (Signal peptide probabilty 0.883) with cleavage site probability 0.565 between residues 27 and 28 218493003098 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 218493003099 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 218493003100 putative active site [active] 218493003101 catalytic triad [active] 218493003102 putative dimer interface [polypeptide binding]; other site 218493003103 8 probable transmembrane helices predicted for SBG0564 by TMHMM2.0 at aa 12-29, 33-50, 57-79, 89-111,124-146, 166-188, 195-213 and 488-507 218493003105 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 218493003106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218493003107 Transporter associated domain; Region: CorC_HlyC; smart01091 218493003110 metal-binding heat shock protein; Provisional; Region: PRK00016 218493003113 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 218493003114 PhoH-like protein; Region: PhoH; pfam02562 218493003117 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 218493003118 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218493003119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493003120 FeS/SAM binding site; other site 218493003121 TRAM domain; Region: TRAM; pfam01938 218493003126 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 218493003127 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 218493003130 asparagine synthetase B; Provisional; Region: asnB; PRK09431 218493003131 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 218493003132 active site 218493003133 dimer interface [polypeptide binding]; other site 218493003134 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 218493003135 Ligand Binding Site [chemical binding]; other site 218493003136 Molecular Tunnel; other site 218493003140 UMP phosphatase; Provisional; Region: PRK10444 218493003141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493003142 active site 218493003143 motif I; other site 218493003144 motif II; other site 218493003145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493003147 MarR family; Region: MarR; pfam01047 218493003148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218493003149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493003150 nucleotide binding site [chemical binding]; other site 218493003154 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 218493003155 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 218493003156 active site 218493003157 dimer interface [polypeptide binding]; other site 218493003159 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 218493003160 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 218493003161 active site 218493003162 trimer interface [polypeptide binding]; other site 218493003163 allosteric site; other site 218493003164 active site lid [active] 218493003165 hexamer (dimer of trimers) interface [polypeptide binding]; other site 218493003169 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 218493003170 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218493003171 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493003172 active site turn [active] 218493003173 phosphorylation site [posttranslational modification] 218493003174 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218493003175 HPr interaction site; other site 218493003176 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218493003177 active site 218493003178 phosphorylation site [posttranslational modification] 218493003180 11 probable transmembrane helices predicted for SBG0575 by TMHMM2.0 at aa 13-30, 40-62, 69-91, 96-118,131-153, 163-185, 192-214, 229-251, 258-280, 295-317 and 337-359 218493003185 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 218493003186 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218493003187 active site 218493003188 HIGH motif; other site 218493003189 nucleotide binding site [chemical binding]; other site 218493003190 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 218493003191 KMSKS motif; other site 218493003192 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 218493003196 signal peptide predicted for SBG0577 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.978 between residues 32 and 33 218493003197 outer membrane porin, OprD family; Region: OprD; pfam03573 218493003199 1 probable transmembrane helix predicted for SBG0577 by TMHMM2.0 at aa 13-35 218493003200 signal peptide predicted for SBG0578 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.395 between residues 19 and 20 218493003201 YbfN-like lipoprotein; Region: YbfN; pfam13982 218493003203 citrate-proton symporter; Provisional; Region: PRK15075 218493003204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493003205 putative substrate translocation pore; other site 218493003206 10 probable transmembrane helices predicted for SBG0579 by TMHMM2.0 at aa 20-42, 57-79, 91-113,185-207, 239-261, 276-298, 305-327, 337-356, 369-391 and 401-423 218493003212 tricarballylate utilization protein B; Provisional; Region: PRK15033 218493003213 6 probable transmembrane helices predicted for SBG0580 by TMHMM2.0 at aa 112-134, 154-176, 230-252,262-284, 305-322 and 327-349 218493003215 tricarballylate dehydrogenase; Validated; Region: PRK08274 218493003218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493003219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493003220 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 218493003221 putative dimerization interface [polypeptide binding]; other site 218493003224 ferric uptake regulator; Provisional; Region: fur; PRK09462 218493003225 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 218493003226 metal binding site 2 [ion binding]; metal-binding site 218493003227 putative DNA binding helix; other site 218493003228 metal binding site 1 [ion binding]; metal-binding site 218493003229 dimer interface [polypeptide binding]; other site 218493003230 structural Zn2+ binding site [ion binding]; other site 218493003232 flavodoxin FldA; Validated; Region: PRK09267 218493003235 LexA regulated protein; Provisional; Region: PRK11675 218493003237 acyl-CoA esterase; Provisional; Region: PRK10673 218493003238 PGAP1-like protein; Region: PGAP1; pfam07819 218493003241 replication initiation regulator SeqA; Provisional; Region: PRK11187 218493003243 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 218493003244 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 218493003245 active site 218493003246 substrate binding site [chemical binding]; other site 218493003247 metal binding site [ion binding]; metal-binding site 218493003253 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 218493003254 putrescine transporter; Provisional; Region: potE; PRK10655 218493003256 12 probable transmembrane helices predicted for SBG0590 by TMHMM2.0 at aa 9-31, 37-59, 89-111,121-143, 150-172, 187-206, 227-249, 269-291, 325-342,352-374, 387-405 and 410-429 218493003258 ornithine decarboxylase; Provisional; Region: PRK13578 218493003259 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218493003260 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218493003261 homodimer interface [polypeptide binding]; other site 218493003262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493003263 catalytic residue [active] 218493003264 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218493003269 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 218493003270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493003271 active site 218493003272 phosphorylation site [posttranslational modification] 218493003273 intermolecular recognition site; other site 218493003274 dimerization interface [polypeptide binding]; other site 218493003275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493003276 DNA binding site [nucleotide binding] 218493003279 sensor protein KdpD; Provisional; Region: PRK10490 218493003280 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 218493003281 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 218493003282 Ligand Binding Site [chemical binding]; other site 218493003283 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 218493003284 GAF domain; Region: GAF_3; pfam13492 218493003285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493003286 dimer interface [polypeptide binding]; other site 218493003287 phosphorylation site [posttranslational modification] 218493003288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493003289 ATP binding site [chemical binding]; other site 218493003290 Mg2+ binding site [ion binding]; other site 218493003291 G-X-G motif; other site 218493003294 4 probable transmembrane helices predicted for SBG0593 by TMHMM2.0 at aa 399-421, 425-444, 449-471 and 476-498 218493003298 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 218493003299 signal peptide predicted for SBG0594 by SignalP 2.0 HMM (Signal peptide probabilty 0.758) with cleavage site probability 0.547 between residues 28 and 29 218493003301 1 probable transmembrane helix predicted for SBG0594 by TMHMM2.0 at aa 12-34 218493003302 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 218493003303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493003304 7 probable transmembrane helices predicted for SBG0595 by TMHMM2.0 at aa 37-59, 63-82, 220-242, 252-274,578-600, 615-634 and 654-676 218493003309 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 218493003310 signal peptide predicted for SBG0596 by SignalP 2.0 HMM (Signal peptide probabilty 0.921) with cleavage site probability 0.780 between residues 20 and 21 218493003312 12 probable transmembrane helices predicted for SBG0596 by TMHMM2.0 at aa 5-27, 63-85, 130-152,173-195, 253-275, 282-301, 325-347, 354-376, 380-399,416-438, 483-505 and 526-548 218493003314 1 probable transmembrane helix predicted for SBG0597 by TMHMM2.0 at aa 37-59 218493003315 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 218493003316 1 probable transmembrane helix predicted for SBG0598 by TMHMM2.0 at aa 11-33 218493003317 Protein of unknown function (DUF796); Region: DUF796; cl01226 218493003318 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218493003320 signal peptide predicted for SBG0600 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.956 between residues 22 and 23 218493003321 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218493003322 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218493003323 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 218493003324 DNA photolyase; Region: DNA_photolyase; pfam00875 218493003329 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 218493003330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493003331 putative substrate translocation pore; other site 218493003332 POT family; Region: PTR2; pfam00854 218493003333 14 probable transmembrane helices predicted for SBG0603 by TMHMM2.0 at aa 13-35, 50-67, 72-94, 98-117,138-157, 167-189, 209-231, 235-254, 267-284, 310-332,344-366, 376-398, 410-432 and 462-479 218493003337 Uncharacterized conserved protein [Function unknown]; Region: COG0327 218493003338 metal-binding protein; Provisional; Region: PRK10799 218493003340 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 218493003341 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 218493003343 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 218493003345 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 218493003346 putative active site [active] 218493003348 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218493003349 active site 218493003350 DNA binding site [nucleotide binding] 218493003351 Int/Topo IB signature motif; other site 218493003353 1 probable transmembrane helix predicted for SBG0609 by TMHMM2.0 at aa 77-99 218493003354 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 218493003355 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 218493003356 Substrate binding site; other site 218493003357 Cupin domain; Region: Cupin_2; cl17218 218493003360 phosphomannomutase CpsG; Provisional; Region: PRK15414 218493003361 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 218493003362 active site 218493003363 substrate binding site [chemical binding]; other site 218493003364 metal binding site [ion binding]; metal-binding site 218493003370 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 218493003371 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 218493003373 6 probable transmembrane helices predicted for SBG0613 by TMHMM2.0 at aa 27-49, 64-86, 106-128, 148-170,177-194 and 229-247 218493003374 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 218493003375 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 218493003376 Walker A/P-loop; other site 218493003377 ATP binding site [chemical binding]; other site 218493003378 Q-loop/lid; other site 218493003379 ABC transporter signature motif; other site 218493003380 Walker B; other site 218493003381 D-loop; other site 218493003382 H-loop/switch region; other site 218493003383 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 218493003384 putative carbohydrate binding site [chemical binding]; other site 218493003388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493003389 S-adenosylmethionine binding site [chemical binding]; other site 218493003390 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 218493003391 active site 218493003392 ATP binding site [chemical binding]; other site 218493003393 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 218493003396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493003397 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 218493003398 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 218493003399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493003402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493003403 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 218493003406 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 218493003407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493003408 putative ADP-binding pocket [chemical binding]; other site 218493003410 signal peptide predicted for SBG0619 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.961 between residues 23 and 24 218493003411 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 218493003412 active site 218493003413 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493003416 Predicted membrane protein [Function unknown]; Region: COG3817 218493003417 1 probable transmembrane helix predicted for SBG0621 by TMHMM2.0 at aa 63-85 218493003418 endonuclease VIII; Provisional; Region: PRK10445 218493003419 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 218493003420 DNA binding site [nucleotide binding] 218493003421 catalytic residue [active] 218493003422 putative catalytic residues [active] 218493003423 H2TH interface [polypeptide binding]; other site 218493003424 intercalation triad [nucleotide binding]; other site 218493003425 substrate specificity determining residue; other site 218493003426 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218493003427 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218493003430 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 218493003431 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 218493003432 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 218493003434 6 probable transmembrane helices predicted for SBG0623 by TMHMM2.0 at aa 21-38, 53-75, 116-135, 155-174,234-256 and 289-311 218493003437 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 218493003438 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 218493003439 dimer interface [polypeptide binding]; other site 218493003440 active site 218493003441 citrylCoA binding site [chemical binding]; other site 218493003442 NADH binding [chemical binding]; other site 218493003443 cationic pore residues; other site 218493003444 oxalacetate/citrate binding site [chemical binding]; other site 218493003445 coenzyme A binding site [chemical binding]; other site 218493003446 catalytic triad [active] 218493003449 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 218493003450 Iron-sulfur protein interface; other site 218493003451 proximal quinone binding site [chemical binding]; other site 218493003452 SdhD (CybS) interface [polypeptide binding]; other site 218493003453 proximal heme binding site [chemical binding]; other site 218493003456 3 probable transmembrane helices predicted for SBG0626 by TMHMM2.0 at aa 27-49, 69-88 and 109-128 218493003458 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 218493003459 SdhC subunit interface [polypeptide binding]; other site 218493003460 proximal heme binding site [chemical binding]; other site 218493003461 cardiolipin binding site; other site 218493003462 Iron-sulfur protein interface; other site 218493003463 proximal quinone binding site [chemical binding]; other site 218493003464 3 probable transmembrane helices predicted for SBG0627 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 218493003465 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 218493003466 L-aspartate oxidase; Provisional; Region: PRK06175 218493003467 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218493003471 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 218493003472 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 218493003474 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 218493003475 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 218493003476 TPP-binding site [chemical binding]; other site 218493003477 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 218493003478 dimer interface [polypeptide binding]; other site 218493003479 PYR/PP interface [polypeptide binding]; other site 218493003480 TPP binding site [chemical binding]; other site 218493003484 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 218493003485 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218493003486 E3 interaction surface; other site 218493003487 lipoyl attachment site [posttranslational modification]; other site 218493003488 e3 binding domain; Region: E3_binding; pfam02817 218493003489 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218493003494 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 218493003495 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 218493003496 CoA-ligase; Region: Ligase_CoA; pfam00549 218493003501 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 218493003502 CoA binding domain; Region: CoA_binding; smart00881 218493003503 CoA-ligase; Region: Ligase_CoA; pfam00549 218493003508 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 218493003509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493003510 DNA-binding site [nucleotide binding]; DNA binding site 218493003511 UTRA domain; Region: UTRA; pfam07702 218493003514 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 218493003515 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493003516 active site 218493003517 phosphorylation site [posttranslational modification] 218493003518 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218493003519 active site 218493003520 P-loop; other site 218493003521 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 218493003526 9 probable transmembrane helices predicted for SBG0634 by TMHMM2.0 at aa 329-351, 364-386, 396-418,438-460, 470-492, 505-527, 557-574, 581-603 and 626-648 218493003527 alpha-mannosidase; Provisional; Region: PRK09819 218493003528 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 218493003529 active site 218493003530 metal binding site [ion binding]; metal-binding site 218493003531 catalytic site [active] 218493003532 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 218493003535 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 218493003536 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 218493003538 9 probable transmembrane helices predicted for SBG0636 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-152,184-206, 219-238, 387-409, 421-443 and 472-494 218493003539 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 218493003540 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 218493003542 8 probable transmembrane helices predicted for SBG0637 by TMHMM2.0 at aa 7-24, 77-99, 122-144, 159-181,202-224, 262-281, 293-315 and 335-357 218493003544 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 218493003545 signal peptide predicted for SBG0638 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.730 between residues 23 and 24 218493003547 1 probable transmembrane helix predicted for SBG0638 by TMHMM2.0 at aa 2-24 218493003549 hypothetical protein; Provisional; Region: PRK10588 218493003550 signal peptide predicted for SBG0639 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.705 between residues 36 and 37 218493003551 3 probable transmembrane helices predicted for SBG0639 by TMHMM2.0 at aa 13-32, 42-64 and 69-91 218493003553 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218493003554 active site 218493003557 colicin uptake protein TolQ; Provisional; Region: PRK10801 218493003558 3 probable transmembrane helices predicted for SBG0641 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 218493003560 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218493003561 colicin uptake protein TolR; Provisional; Region: PRK11024 218493003563 1 probable transmembrane helix predicted for SBG0642 by TMHMM2.0 at aa 17-39 218493003564 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 218493003565 TolA C-terminal; Region: TolA; pfam06519 218493003567 1 probable transmembrane helix predicted for SBG0643 by TMHMM2.0 at aa 13-35 218493003569 signal peptide predicted for SBG0644 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.989 between residues 21 and 22 218493003570 translocation protein TolB; Provisional; Region: tolB; PRK03629 218493003571 TolB amino-terminal domain; Region: TolB_N; pfam04052 218493003572 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218493003573 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218493003574 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218493003581 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 218493003582 signal peptide predicted for SBG0645 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.727 between residues 28 and 29 218493003583 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218493003584 ligand binding site [chemical binding]; other site 218493003588 tol-pal system protein YbgF; Provisional; Region: PRK10803 218493003589 signal peptide predicted for SBG0646 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 26 and 27 218493003590 Tetratricopeptide repeat; Region: TPR_6; pfam13174 218493003591 Tetratricopeptide repeat; Region: TPR_6; pfam13174 218493003594 quinolinate synthetase; Provisional; Region: PRK09375 218493003596 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 218493003598 6 probable transmembrane helices predicted for SBG0648 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-132,158-177 and 184-206 218493003599 zinc transporter ZitB; Provisional; Region: PRK03557 218493003602 2 probable transmembrane helices predicted for SBG0649 by TMHMM2.0 at aa 2-19 and 34-56 218493003603 signal peptide predicted for SBG0651 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 24 and 25 218493003604 YbgS-like protein; Region: YbgS; pfam13985 218493003605 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 218493003606 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218493003608 1 probable transmembrane helix predicted for SBG0653 by TMHMM2.0 at aa 29-51 218493003610 signal peptide predicted for SBG0654 by SignalP 2.0 HMM (Signal peptide probabilty 0.844) with cleavage site probability 0.587 between residues 39 and 40 218493003611 1 probable transmembrane helix predicted for SBG0654 by TMHMM2.0 at aa 31-53 218493003613 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218493003614 catalytic core [active] 218493003615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218493003618 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 218493003619 active site 218493003620 catalytic residues [active] 218493003623 galactokinase; Provisional; Region: PRK05101 218493003624 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 218493003625 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 218493003630 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 218493003631 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 218493003632 dimer interface [polypeptide binding]; other site 218493003633 active site 218493003637 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 218493003638 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 218493003639 NAD binding site [chemical binding]; other site 218493003640 homodimer interface [polypeptide binding]; other site 218493003641 active site 218493003642 substrate binding site [chemical binding]; other site 218493003644 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 218493003645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493003646 Walker A/P-loop; other site 218493003647 ATP binding site [chemical binding]; other site 218493003648 Q-loop/lid; other site 218493003649 ABC transporter signature motif; other site 218493003650 Walker B; other site 218493003651 D-loop; other site 218493003652 H-loop/switch region; other site 218493003653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493003654 Walker A/P-loop; other site 218493003655 ATP binding site [chemical binding]; other site 218493003656 Q-loop/lid; other site 218493003657 ABC transporter signature motif; other site 218493003658 Walker B; other site 218493003659 D-loop; other site 218493003660 H-loop/switch region; other site 218493003665 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 218493003666 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 218493003667 molybdenum-pterin binding domain; Region: Mop; TIGR00638 218493003668 TOBE domain; Region: TOBE; pfam03459 218493003672 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 218493003673 signal peptide predicted for SBG0662 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25 218493003674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493003675 substrate binding pocket [chemical binding]; other site 218493003676 membrane-bound complex binding site; other site 218493003677 hinge residues; other site 218493003681 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218493003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493003683 dimer interface [polypeptide binding]; other site 218493003684 conserved gate region; other site 218493003685 putative PBP binding loops; other site 218493003686 ABC-ATPase subunit interface; other site 218493003688 5 probable transmembrane helices predicted for SBG0663 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219 218493003690 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 218493003691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493003692 Walker A/P-loop; other site 218493003693 ATP binding site [chemical binding]; other site 218493003694 Q-loop/lid; other site 218493003695 ABC transporter signature motif; other site 218493003696 Walker B; other site 218493003697 D-loop; other site 218493003698 H-loop/switch region; other site 218493003699 molybdenum-pterin binding domain; Region: Mop; TIGR00638 218493003704 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 218493003705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493003706 active site 218493003707 motif I; other site 218493003708 motif II; other site 218493003709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493003713 6-phosphogluconolactonase; Provisional; Region: PRK11028 218493003714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493003715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493003716 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 218493003717 putative dimerization interface [polypeptide binding]; other site 218493003719 1 probable transmembrane helix predicted for SBG0667 by TMHMM2.0 at aa 90-112 218493003723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 218493003725 signal peptide predicted for SBG0669 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.517 between residues 28 and 29 218493003726 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493003727 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218493003728 transmembrane helices; other site 218493003730 15 probable transmembrane helices predicted for SBG0669 by TMHMM2.0 at aa 5-27, 31-48, 55-76, 86-108,115-137, 147-166, 178-200, 222-244, 274-293, 297-314,327-349, 364-381, 394-416, 421-439 and 446-468 218493003731 putative hydratase; Provisional; Region: PRK11413 218493003732 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 218493003733 substrate binding site [chemical binding]; other site 218493003734 ligand binding site [chemical binding]; other site 218493003735 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 218493003736 substrate binding site [chemical binding]; other site 218493003739 acyl-CoA thioesterase; Provisional; Region: PRK10531 218493003740 signal peptide predicted for SBG0671 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.667 between residues 23 and 24 218493003741 putative pectinesterase; Region: PLN02432; cl01911 218493003750 imidazolonepropionase; Validated; Region: PRK09356 218493003751 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 218493003752 active site 218493003754 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 218493003755 putative active site [active] 218493003756 putative metal binding site [ion binding]; other site 218493003760 histidine utilization repressor; Provisional; Region: PRK14999 218493003761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493003762 DNA-binding site [nucleotide binding]; DNA binding site 218493003763 UTRA domain; Region: UTRA; pfam07702 218493003767 urocanate hydratase; Provisional; Region: PRK05414 218493003771 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 218493003772 active sites [active] 218493003773 tetramer interface [polypeptide binding]; other site 218493003777 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 218493003778 substrate binding site [chemical binding]; other site 218493003780 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 218493003781 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493003782 inhibitor-cofactor binding pocket; inhibition site 218493003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493003784 catalytic residue [active] 218493003787 biotin synthase; Provisional; Region: PRK15108 218493003788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493003789 FeS/SAM binding site; other site 218493003790 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 218493003794 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 218493003795 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 218493003796 substrate-cofactor binding pocket; other site 218493003797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493003798 catalytic residue [active] 218493003801 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 218493003802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493003803 S-adenosylmethionine binding site [chemical binding]; other site 218493003805 AAA domain; Region: AAA_26; pfam13500 218493003806 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 218493003808 excinuclease ABC subunit B; Provisional; Region: PRK05298 218493003809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493003810 ATP binding site [chemical binding]; other site 218493003811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493003812 nucleotide binding region [chemical binding]; other site 218493003813 ATP-binding site [chemical binding]; other site 218493003814 Ultra-violet resistance protein B; Region: UvrB; pfam12344 218493003815 UvrB/uvrC motif; Region: UVR; pfam02151 218493003820 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 218493003821 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 218493003822 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 218493003828 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 218493003829 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 218493003830 putative substrate binding pocket [chemical binding]; other site 218493003831 dimer interface [polypeptide binding]; other site 218493003832 phosphate binding site [ion binding]; other site 218493003834 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 218493003835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493003836 FeS/SAM binding site; other site 218493003837 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 218493003841 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 218493003842 MPT binding site; other site 218493003843 trimer interface [polypeptide binding]; other site 218493003846 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 218493003847 trimer interface [polypeptide binding]; other site 218493003848 dimer interface [polypeptide binding]; other site 218493003849 putative active site [active] 218493003851 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 218493003852 MoaE interaction surface [polypeptide binding]; other site 218493003853 MoeB interaction surface [polypeptide binding]; other site 218493003854 thiocarboxylated glycine; other site 218493003856 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 218493003857 MoaE homodimer interface [polypeptide binding]; other site 218493003858 MoaD interaction [polypeptide binding]; other site 218493003859 active site residues [active] 218493003861 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 218493003862 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 218493003864 7 probable transmembrane helices predicted for SBG0695 by TMHMM2.0 at aa 20-42, 57-76, 88-107, 112-131,138-160, 165-184 and 209-231 218493003865 signal peptide predicted for SBG0696 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.905 between residues 31 and 32 218493003866 Predicted integral membrane protein [Function unknown]; Region: COG0392 218493003867 8 probable transmembrane helices predicted for SBG0696 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 127-149,162-184, 204-226, 233-255 and 281-303 218493003869 cardiolipin synthase 2; Provisional; Region: PRK11263 218493003870 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 218493003871 putative active site [active] 218493003872 catalytic site [active] 218493003873 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 218493003874 putative active site [active] 218493003875 catalytic site [active] 218493003878 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 218493003879 putative catalytic site [active] 218493003880 putative metal binding site [ion binding]; other site 218493003881 putative phosphate binding site [ion binding]; other site 218493003883 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 218493003884 4 probable transmembrane helices predicted for SBG0699 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119 218493003885 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218493003886 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 218493003887 6 probable transmembrane helices predicted for SBG0700 by TMHMM2.0 at aa 24-46, 173-195, 223-245,255-277, 284-303 and 341-363 218493003889 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 218493003890 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218493003891 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 218493003892 6 probable transmembrane helices predicted for SBG0701 by TMHMM2.0 at aa 26-48, 181-203, 230-252,262-284, 291-313 and 347-369 218493003894 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218493003895 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218493003896 Walker A/P-loop; other site 218493003897 ATP binding site [chemical binding]; other site 218493003898 Q-loop/lid; other site 218493003899 ABC transporter signature motif; other site 218493003900 Walker B; other site 218493003901 D-loop; other site 218493003902 H-loop/switch region; other site 218493003903 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 218493003904 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218493003905 Walker A/P-loop; other site 218493003906 ATP binding site [chemical binding]; other site 218493003907 Q-loop/lid; other site 218493003908 ABC transporter signature motif; other site 218493003909 Walker B; other site 218493003910 D-loop; other site 218493003911 H-loop/switch region; other site 218493003917 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 218493003918 signal peptide predicted for SBG0703 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.933 between residues 19 and 20 218493003919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493003920 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493003922 1 probable transmembrane helix predicted for SBG0703 by TMHMM2.0 at aa 5-27 218493003923 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 218493003924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493003925 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 218493003929 helicase 45; Provisional; Region: PTZ00424 218493003930 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218493003931 ATP binding site [chemical binding]; other site 218493003932 Mg++ binding site [ion binding]; other site 218493003933 motif III; other site 218493003934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493003935 nucleotide binding region [chemical binding]; other site 218493003936 ATP-binding site [chemical binding]; other site 218493003941 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 218493003942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 218493003943 DEAD_2; Region: DEAD_2; pfam06733 218493003944 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 218493003946 glycosyl transferase family protein; Provisional; Region: PRK08136 218493003947 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218493003949 hypothetical protein; Provisional; Region: PRK10259 218493003951 hypothetical protein; Provisional; Region: PRK11019 218493003954 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 218493003955 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 218493003957 putative mechanosensitive channel protein; Provisional; Region: PRK11465 218493003958 signal peptide predicted for SBG0711 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.898 between residues 18 and 19 218493003959 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493003961 11 probable transmembrane helices predicted for SBG0711 by TMHMM2.0 at aa 5-27, 138-160, 181-203,218-240, 268-287, 292-314, 335-357, 372-394, 429-451,466-488 and 509-531 218493003962 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 218493003963 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218493003964 Walker A/P-loop; other site 218493003965 ATP binding site [chemical binding]; other site 218493003966 Q-loop/lid; other site 218493003967 ABC transporter signature motif; other site 218493003968 Walker B; other site 218493003969 D-loop; other site 218493003970 H-loop/switch region; other site 218493003974 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493003976 dimer interface [polypeptide binding]; other site 218493003977 conserved gate region; other site 218493003978 putative PBP binding loops; other site 218493003979 ABC-ATPase subunit interface; other site 218493003981 5 probable transmembrane helices predicted for SBG0713 by TMHMM2.0 at aa 20-42, 55-77, 92-114, 155-177 and 187-209 218493003983 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 218493003984 signal peptide predicted for SBG0714 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493003985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493003986 substrate binding pocket [chemical binding]; other site 218493003987 membrane-bound complex binding site; other site 218493003988 hinge residues; other site 218493003991 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 218493003992 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 218493003993 dimerization interface [polypeptide binding]; other site 218493003994 DPS ferroxidase diiron center [ion binding]; other site 218493003995 ion pore; other site 218493003999 threonine and homoserine efflux system; Provisional; Region: PRK10532 218493004000 signal peptide predicted for SBG0716 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.905 between residues 31 and 32 218493004001 EamA-like transporter family; Region: EamA; pfam00892 218493004002 10 probable transmembrane helices predicted for SBG0716 by TMHMM2.0 at aa 7-24, 37-59, 72-89, 93-115,122-139, 143-165, 177-199, 203-225, 238-257 and 261-283 218493004005 outer membrane protein X; Provisional; Region: ompX; PRK09408 218493004006 signal peptide predicted for SBG0717 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493004008 1 probable transmembrane helix predicted for SBG0717 by TMHMM2.0 at aa 7-29 218493004011 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 218493004012 Sulfatase; Region: Sulfatase; pfam00884 218493004014 4 probable transmembrane helices predicted for SBG0718 by TMHMM2.0 at aa 32-54, 63-85, 105-127 and 144-166 218493004015 manganese transport regulator MntR; Provisional; Region: PRK11050 218493004016 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 218493004017 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 218493004020 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493004021 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 218493004022 transmembrane helices; other site 218493004024 9 probable transmembrane helices predicted for SBG0721 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 163-182,202-219, 223-242, 249-271, 312-334 and 347-369 218493004025 L,D-transpeptidase; Provisional; Region: PRK10260 218493004026 signal peptide predicted for SBG0722 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.717 between residues 24 and 25 218493004027 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493004029 1 probable transmembrane helix predicted for SBG0722 by TMHMM2.0 at aa 7-29 218493004030 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 218493004031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493004032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004033 Walker A/P-loop; other site 218493004034 ATP binding site [chemical binding]; other site 218493004035 ABC transporter signature motif; other site 218493004036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493004037 Walker B; other site 218493004038 ABC transporter; Region: ABC_tran_2; pfam12848 218493004039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493004044 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 218493004045 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 218493004046 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 218493004047 putative active site [active] 218493004048 putative catalytic site [active] 218493004051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493004052 D-galactonate transporter; Region: 2A0114; TIGR00893 218493004053 putative substrate translocation pore; other site 218493004054 10 probable transmembrane helices predicted for SBG0725 by TMHMM2.0 at aa 21-38, 96-118, 148-170,180-199, 241-263, 278-300, 313-335, 340-362, 375-397 and 407-426 218493004057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493004058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493004059 DNA binding site [nucleotide binding] 218493004060 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 218493004061 ligand binding site [chemical binding]; other site 218493004062 dimerization interface [polypeptide binding]; other site 218493004065 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 218493004067 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 218493004068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493004069 active site 218493004070 motif I; other site 218493004071 motif II; other site 218493004072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493004075 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 218493004076 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 218493004077 dimer interface [polypeptide binding]; other site 218493004078 active site 218493004079 glycine loop; other site 218493004083 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 218493004084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493004085 FeS/SAM binding site; other site 218493004088 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 218493004089 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 218493004090 ATP binding site [chemical binding]; other site 218493004091 substrate interface [chemical binding]; other site 218493004095 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 218493004096 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 218493004097 dimer interface [polypeptide binding]; other site 218493004098 putative functional site; other site 218493004099 putative MPT binding site; other site 218493004104 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 218493004105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493004106 Walker A/P-loop; other site 218493004107 ATP binding site [chemical binding]; other site 218493004108 Q-loop/lid; other site 218493004109 ABC transporter signature motif; other site 218493004110 Walker B; other site 218493004111 D-loop; other site 218493004112 H-loop/switch region; other site 218493004113 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218493004114 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493004115 Walker A/P-loop; other site 218493004116 ATP binding site [chemical binding]; other site 218493004117 Q-loop/lid; other site 218493004118 ABC transporter signature motif; other site 218493004119 Walker B; other site 218493004120 D-loop; other site 218493004121 H-loop/switch region; other site 218493004122 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218493004131 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 218493004132 signal peptide predicted for SBG0734 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 26 and 27 218493004133 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 218493004135 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 218493004136 signal peptide predicted for SBG0735 by SignalP 2.0 HMM (Signal peptide probabilty 0.848) with cleavage site probability 0.441 between residues 29 and 30 218493004137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004138 dimer interface [polypeptide binding]; other site 218493004139 conserved gate region; other site 218493004140 putative PBP binding loops; other site 218493004141 ABC-ATPase subunit interface; other site 218493004142 6 probable transmembrane helices predicted for SBG0735 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189,227-249 and 278-300 218493004145 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 218493004146 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218493004147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004148 dimer interface [polypeptide binding]; other site 218493004149 conserved gate region; other site 218493004150 putative PBP binding loops; other site 218493004151 ABC-ATPase subunit interface; other site 218493004152 6 probable transmembrane helices predicted for SBG0736 by TMHMM2.0 at aa 39-61, 103-125, 138-160,164-183, 225-247 and 267-289 218493004155 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 218493004156 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218493004157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493004158 FeS/SAM binding site; other site 218493004163 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 218493004164 signal peptide predicted for SBG0739 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.826 between residues 20 and 21 218493004165 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 218493004166 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 218493004168 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218493004169 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 218493004170 putative C-terminal domain interface [polypeptide binding]; other site 218493004171 putative GSH binding site (G-site) [chemical binding]; other site 218493004172 putative dimer interface [polypeptide binding]; other site 218493004173 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 218493004174 putative N-terminal domain interface [polypeptide binding]; other site 218493004175 putative dimer interface [polypeptide binding]; other site 218493004176 putative substrate binding pocket (H-site) [chemical binding]; other site 218493004179 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 218493004180 signal peptide predicted for SBG0741 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 27 and 28 218493004181 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218493004182 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 218493004185 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 218493004186 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218493004187 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493004191 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493004192 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 218493004193 active site 218493004195 5 probable transmembrane helices predicted for SBG0743 by TMHMM2.0 at aa 26-48, 60-82, 105-124, 126-145 and 150-172 218493004197 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 218493004198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493004199 putative substrate translocation pore; other site 218493004200 12 probable transmembrane helices predicted for SBG0744 by TMHMM2.0 at aa 16-38, 53-72, 84-101,111-130, 142-164, 169-188, 220-242, 257-279, 286-308,313-335, 348-367 and 377-399 218493004203 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 218493004204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493004205 active site 218493004206 motif I; other site 218493004207 motif II; other site 218493004208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493004211 signal peptide predicted for SBG0746 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.807 between residues 29 and 30 218493004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493004213 putative substrate translocation pore; other site 218493004214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493004215 12 probable transmembrane helices predicted for SBG0746 by TMHMM2.0 at aa 12-34, 49-71, 78-100,104-126, 146-168, 172-191, 211-233, 253-275, 282-301,305-327, 340-362 and 367-389 218493004217 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 218493004218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493004219 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 218493004221 degenerate P2-family prophage: SB84 218493004224 baseplate wedge subunit; Provisional; Region: W; PHA02516 218493004226 baseplate assembly protein; Provisional; Region: J; PHA02568 218493004228 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 218493004229 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 218493004230 9 probable transmembrane helices predicted for SBG0755 by TMHMM2.0 at aa 5-24, 45-67, 82-99, 116-138,211-233, 253-270, 275-297, 304-326 and 341-363 218493004232 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 218493004243 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 218493004245 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 218493004248 Phage protein U [General function prediction only]; Region: COG3499 218493004250 tail protein; Provisional; Region: D; PHA02561 218493004252 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 218493004253 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218493004255 putative transporter; Provisional; Region: PRK04972 218493004256 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 218493004257 TrkA-C domain; Region: TrkA_C; pfam02080 218493004258 TrkA-C domain; Region: TrkA_C; pfam02080 218493004259 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 218493004260 9 probable transmembrane helices predicted for SBG0766 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181,383-402, 406-428, 449-471, 476-498 and 535-557 218493004265 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 218493004266 signal peptide predicted for SBG0767 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.581 between residues 33 and 34 218493004267 4 probable transmembrane helices predicted for SBG0767 by TMHMM2.0 at aa 7-29, 34-56, 61-83 and 93-115 218493004268 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 218493004269 GSH binding site [chemical binding]; other site 218493004270 catalytic residues [active] 218493004273 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 218493004275 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 218493004276 dimer interface [polypeptide binding]; other site 218493004277 FMN binding site [chemical binding]; other site 218493004278 NADPH bind site [chemical binding]; other site 218493004280 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 218493004281 RimK-like ATP-grasp domain; Region: RimK; pfam08443 218493004283 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 218493004284 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 218493004285 signal peptide predicted for SBG0772 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.963 between residues 26 and 27 218493004286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 218493004288 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 218493004289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004290 Walker A/P-loop; other site 218493004291 ATP binding site [chemical binding]; other site 218493004292 Q-loop/lid; other site 218493004293 ABC transporter signature motif; other site 218493004294 Walker B; other site 218493004295 D-loop; other site 218493004296 H-loop/switch region; other site 218493004297 TOBE domain; Region: TOBE_2; pfam08402 218493004302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004303 dimer interface [polypeptide binding]; other site 218493004304 conserved gate region; other site 218493004305 putative PBP binding loops; other site 218493004306 ABC-ATPase subunit interface; other site 218493004308 6 probable transmembrane helices predicted for SBG0774 by TMHMM2.0 at aa 31-52, 100-122, 135-157,185-207, 228-250 and 284-306 218493004311 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218493004312 signal peptide predicted for SBG0775 by SignalP 2.0 HMM (Signal peptide probabilty 0.851) with cleavage site probability 0.594 between residues 45 and 46 218493004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004314 dimer interface [polypeptide binding]; other site 218493004315 conserved gate region; other site 218493004316 putative PBP binding loops; other site 218493004317 ABC-ATPase subunit interface; other site 218493004318 6 probable transmembrane helices predicted for SBG0775 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163,184-206 and 242-264 218493004322 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 218493004323 4 probable transmembrane helices predicted for SBG0776 by TMHMM2.0 at aa 13-35, 60-82, 89-111 and 126-148 218493004324 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 218493004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493004326 S-adenosylmethionine binding site [chemical binding]; other site 218493004330 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 218493004332 11 probable transmembrane helices predicted for SBG0779 by TMHMM2.0 at aa 15-37, 44-66, 103-125,132-154, 159-181, 233-255, 270-292, 330-352, 356-378,385-407 and 422-444 218493004333 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218493004334 active site 218493004335 P-loop; other site 218493004336 phosphorylation site [posttranslational modification] 218493004338 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 218493004339 Sulfatase; Region: Sulfatase; cl17466 218493004341 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 218493004342 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 218493004343 signal peptide predicted for SBG0783 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 19 and 20 218493004344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493004345 substrate binding pocket [chemical binding]; other site 218493004346 membrane-bound complex binding site; other site 218493004347 hinge residues; other site 218493004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004351 dimer interface [polypeptide binding]; other site 218493004352 conserved gate region; other site 218493004353 putative PBP binding loops; other site 218493004354 ABC-ATPase subunit interface; other site 218493004356 5 probable transmembrane helices predicted for SBG0784 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-177 and 187-206 218493004357 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493004358 signal peptide predicted for SBG0785 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.816 between residues 29 and 30 218493004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493004360 dimer interface [polypeptide binding]; other site 218493004361 conserved gate region; other site 218493004362 putative PBP binding loops; other site 218493004363 ABC-ATPase subunit interface; other site 218493004365 4 probable transmembrane helices predicted for SBG0785 by TMHMM2.0 at aa 10-32, 53-75, 101-118 and 201-223 218493004367 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 218493004368 signal peptide predicted for SBG0786 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 19 and 20 218493004369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493004370 substrate binding pocket [chemical binding]; other site 218493004371 membrane-bound complex binding site; other site 218493004372 hinge residues; other site 218493004375 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 218493004376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004377 Walker A/P-loop; other site 218493004378 ATP binding site [chemical binding]; other site 218493004379 Q-loop/lid; other site 218493004380 ABC transporter signature motif; other site 218493004381 Walker B; other site 218493004382 D-loop; other site 218493004383 H-loop/switch region; other site 218493004387 putative lipoprotein; Provisional; Region: PRK10533 218493004388 signal peptide predicted for SBG0788 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.755 between residues 27 and 28 218493004390 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004391 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004392 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004393 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004394 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004395 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004396 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493004397 hypothetical protein; Provisional; Region: PRK02877 218493004399 signal peptide predicted for SBG0792 by SignalP 2.0 HMM (Signal peptide probabilty 0.925) with cleavage site probability 0.417 between residues 20 and 21 218493004400 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 218493004401 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 218493004402 amidase catalytic site [active] 218493004403 Zn binding residues [ion binding]; other site 218493004404 substrate binding site [chemical binding]; other site 218493004407 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218493004408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218493004409 NAD(P) binding site [chemical binding]; other site 218493004410 active site 218493004412 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 218493004413 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 218493004414 putative NAD(P) binding site [chemical binding]; other site 218493004415 putative active site [active] 218493004416 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 218493004417 1 probable transmembrane helix predicted for SBG0794 by TMHMM2.0 at aa 437-459 218493004419 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 218493004420 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 218493004421 tetramer interface [polypeptide binding]; other site 218493004422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493004423 catalytic residue [active] 218493004425 pyruvate dehydrogenase; Provisional; Region: PRK09124 218493004426 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 218493004427 PYR/PP interface [polypeptide binding]; other site 218493004428 dimer interface [polypeptide binding]; other site 218493004429 tetramer interface [polypeptide binding]; other site 218493004430 TPP binding site [chemical binding]; other site 218493004431 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218493004432 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 218493004433 TPP-binding site [chemical binding]; other site 218493004438 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 218493004439 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 218493004440 FAD binding pocket [chemical binding]; other site 218493004441 FAD binding motif [chemical binding]; other site 218493004442 phosphate binding motif [ion binding]; other site 218493004443 beta-alpha-beta structure motif; other site 218493004444 NAD binding pocket [chemical binding]; other site 218493004445 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218493004446 catalytic loop [active] 218493004447 iron binding site [ion binding]; other site 218493004451 hybrid cluster protein; Provisional; Region: PRK05290 218493004452 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493004453 ACS interaction site; other site 218493004454 CODH interaction site; other site 218493004455 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 218493004456 hybrid metal cluster; other site 218493004459 Predicted membrane protein [Function unknown]; Region: COG2431 218493004461 8 probable transmembrane helices predicted for SBG0799 by TMHMM2.0 at aa 4-20, 32-51, 61-83, 111-133,138-155, 167-189, 204-226 and 275-297 218493004463 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 218493004464 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 218493004465 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 218493004466 putative active site [active] 218493004467 putative metal-binding site [ion binding]; other site 218493004469 Protein of unknown function (DUF535); Region: DUF535; pfam04393 218493004471 signal peptide predicted for SBG0802 by SignalP 2.0 HMM (Signal peptide probabilty 0.851) with cleavage site probability 0.247 between residues 32 and 33 218493004472 macrolide transporter subunit MacA; Provisional; Region: PRK11578 218493004473 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493004474 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493004475 1 probable transmembrane helix predicted for SBG0802 by TMHMM2.0 at aa 12-27 218493004477 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 218493004478 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218493004479 Walker A/P-loop; other site 218493004480 ATP binding site [chemical binding]; other site 218493004481 Q-loop/lid; other site 218493004482 ABC transporter signature motif; other site 218493004483 Walker B; other site 218493004484 D-loop; other site 218493004485 H-loop/switch region; other site 218493004486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218493004487 FtsX-like permease family; Region: FtsX; pfam02687 218493004491 5 probable transmembrane helices predicted for SBG0803 by TMHMM2.0 at aa 270-292, 418-437, 524-546,572-594 and 609-631 218493004493 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493004494 DNA-binding site [nucleotide binding]; DNA binding site 218493004495 RNA-binding motif; other site 218493004498 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 218493004500 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 218493004501 Clp amino terminal domain; Region: Clp_N; pfam02861 218493004502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493004503 Walker A motif; other site 218493004504 ATP binding site [chemical binding]; other site 218493004505 Walker B motif; other site 218493004506 arginine finger; other site 218493004507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493004508 Walker A motif; other site 218493004509 ATP binding site [chemical binding]; other site 218493004510 Walker B motif; other site 218493004511 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218493004519 Isochorismatase family; Region: Isochorismatase; pfam00857 218493004520 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 218493004521 catalytic triad [active] 218493004522 dimer interface [polypeptide binding]; other site 218493004523 conserved cis-peptide bond; other site 218493004525 Pirin-related protein [General function prediction only]; Region: COG1741 218493004526 Pirin; Region: Pirin; pfam02678 218493004527 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 218493004530 LysR family transcriptional regulator; Provisional; Region: PRK14997 218493004531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493004532 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 218493004533 putative effector binding pocket; other site 218493004534 putative dimerization interface [polypeptide binding]; other site 218493004537 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 218493004538 rRNA binding site [nucleotide binding]; other site 218493004539 predicted 30S ribosome binding site; other site 218493004541 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 218493004543 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 218493004544 signal peptide predicted for SBG0812 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.687 between residues 49 and 50 218493004545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493004546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004547 Walker A/P-loop; other site 218493004548 ATP binding site [chemical binding]; other site 218493004549 Q-loop/lid; other site 218493004550 ABC transporter signature motif; other site 218493004551 Walker B; other site 218493004552 D-loop; other site 218493004553 H-loop/switch region; other site 218493004557 6 probable transmembrane helices predicted for SBG0812 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182,246-268 and 278-300 218493004558 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 218493004559 signal peptide predicted for SBG0813 by SignalP 2.0 HMM (Signal peptide probabilty 0.868) with cleavage site probability 0.574 between residues 42 and 43 218493004560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493004561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004562 Walker A/P-loop; other site 218493004563 ATP binding site [chemical binding]; other site 218493004564 Q-loop/lid; other site 218493004565 ABC transporter signature motif; other site 218493004566 Walker B; other site 218493004567 D-loop; other site 218493004568 H-loop/switch region; other site 218493004572 6 probable transmembrane helices predicted for SBG0813 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185,245-267 and 282-304 218493004574 thioredoxin reductase; Provisional; Region: PRK10262 218493004575 signal peptide predicted for SBG0814 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.927 between residues 25 and 26 218493004576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493004577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493004581 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 218493004582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493004583 putative DNA binding site [nucleotide binding]; other site 218493004584 putative Zn2+ binding site [ion binding]; other site 218493004585 AsnC family; Region: AsnC_trans_reg; pfam01037 218493004588 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 218493004589 DNA translocase FtsK; Provisional; Region: PRK10263 218493004590 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 218493004591 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 218493004592 5 probable transmembrane helices predicted for SBG0816 by TMHMM2.0 at aa 41-63, 95-117, 129-151, 156-177 and 184-206 218493004597 signal peptide predicted for SBG0817 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 22 and 23 218493004598 periplasmic chaperone LolA; Region: lolA; TIGR00547 218493004599 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 218493004601 recombination factor protein RarA; Reviewed; Region: PRK13342 218493004602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493004603 Walker A motif; other site 218493004604 ATP binding site [chemical binding]; other site 218493004605 Walker B motif; other site 218493004606 arginine finger; other site 218493004607 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 218493004610 seryl-tRNA synthetase; Provisional; Region: PRK05431 218493004611 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 218493004612 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 218493004613 dimer interface [polypeptide binding]; other site 218493004614 active site 218493004615 motif 1; other site 218493004616 motif 2; other site 218493004617 motif 3; other site 218493004621 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 218493004622 signal peptide predicted for SBG0820 by SignalP 2.0 HMM (Signal peptide probabilty 0.844) with cleavage site probability 0.763 between residues 45 and 46 218493004623 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 218493004624 putative [Fe4-S4] binding site [ion binding]; other site 218493004625 putative molybdopterin cofactor binding site [chemical binding]; other site 218493004626 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 218493004627 putative molybdopterin cofactor binding site; other site 218493004634 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 218493004635 4Fe-4S binding domain; Region: Fer4; pfam00037 218493004641 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 218493004643 8 probable transmembrane helices predicted for SBG0822 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-134,149-171, 178-200, 226-243 and 255-277 218493004644 putative MFS family transporter protein; Provisional; Region: PRK03633 218493004645 signal peptide predicted for SBG0823 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.442 between residues 23 and 24 218493004646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493004647 putative substrate translocation pore; other site 218493004648 12 probable transmembrane helices predicted for SBG0823 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-119,131-150, 160-182, 204-226, 236-258, 265-284, 289-311,324-346 and 351-373 218493004653 inner membrane transporter YjeM; Provisional; Region: PRK15238 218493004655 11 probable transmembrane helices predicted for SBG0824 by TMHMM2.0 at aa 10-29, 36-58, 127-146,158-180, 195-217, 238-260, 287-309, 340-362, 377-399,412-434 and 444-466 218493004657 signal peptide predicted for SBG0825 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.992 between residues 40 and 41 218493004658 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 218493004659 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 218493004660 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 218493004661 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493004667 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 218493004668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493004669 FeS/SAM binding site; other site 218493004673 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 218493004674 Pyruvate formate lyase 1; Region: PFL1; cd01678 218493004675 coenzyme A binding site [chemical binding]; other site 218493004676 active site 218493004677 catalytic residues [active] 218493004678 glycine loop; other site 218493004682 formate transporter; Provisional; Region: PRK10805 218493004684 6 probable transmembrane helices predicted for SBG0828 by TMHMM2.0 at aa 34-56, 77-99, 114-136, 161-183,193-215 and 255-277 218493004687 uncharacterized domain; Region: TIGR00702 218493004688 YcaO-like family; Region: YcaO; pfam02624 218493004690 Predicted membrane protein [Function unknown]; Region: COG2323 218493004691 3 probable transmembrane helices predicted for SBG0830 by TMHMM2.0 at aa 15-37, 50-69 and 74-91 218493004693 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 218493004694 homodimer interface [polypeptide binding]; other site 218493004695 substrate-cofactor binding pocket; other site 218493004696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493004697 catalytic residue [active] 218493004700 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 218493004701 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 218493004702 hinge; other site 218493004703 active site 218493004708 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 218493004709 signal peptide predicted for SBG0833 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.364 between residues 23 and 24 218493004713 cytidylate kinase; Provisional; Region: cmk; PRK00023 218493004714 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 218493004715 CMP-binding site; other site 218493004716 The sites determining sugar specificity; other site 218493004718 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 218493004719 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 218493004720 RNA binding site [nucleotide binding]; other site 218493004721 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 218493004722 RNA binding site [nucleotide binding]; other site 218493004723 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 218493004724 RNA binding site [nucleotide binding]; other site 218493004725 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 218493004726 RNA binding site [nucleotide binding]; other site 218493004727 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218493004728 RNA binding site [nucleotide binding]; other site 218493004729 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 218493004730 RNA binding site [nucleotide binding]; other site 218493004737 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218493004738 IHF dimer interface [polypeptide binding]; other site 218493004739 IHF - DNA interface [nucleotide binding]; other site 218493004742 ComEC family competence protein; Provisional; Region: PRK11539 218493004743 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 218493004744 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 218493004745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 218493004746 11 probable transmembrane helices predicted for SBG0837 by TMHMM2.0 at aa 5-22, 26-43, 50-69, 221-243,255-277, 301-323, 328-346, 361-383, 390-412, 427-449 and 469-491 218493004749 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 218493004750 signal peptide predicted for SBG0838 by SignalP 2.0 HMM (Signal peptide probabilty 0.666) with cleavage site probability 0.414 between residues 38 and 39 218493004751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493004752 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 218493004753 Walker A/P-loop; other site 218493004754 ATP binding site [chemical binding]; other site 218493004755 Q-loop/lid; other site 218493004756 ABC transporter signature motif; other site 218493004757 Walker B; other site 218493004758 D-loop; other site 218493004759 H-loop/switch region; other site 218493004760 5 probable transmembrane helices predicted for SBG0838 by TMHMM2.0 at aa 21-43, 63-94, 140-162, 167-186 and 245-267 218493004765 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 218493004766 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 218493004768 1 probable transmembrane helix predicted for SBG0839 by TMHMM2.0 at aa 12-34 218493004769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 218493004770 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 218493004772 hypothetical protein; Provisional; Region: PRK11827 218493004774 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 218493004775 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 218493004776 Ligand binding site; other site 218493004777 oligomer interface; other site 218493004779 hypothetical protein; Provisional; Region: PRK10593 218493004780 signal peptide predicted for SBG0844 by SignalP 2.0 HMM (Signal peptide probabilty 0.742) with cleavage site probability 0.424 between residues 28 and 29 218493004781 Uncharacterized conserved protein [Function unknown]; Region: COG1434 218493004782 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218493004783 putative active site [active] 218493004785 2 probable transmembrane helices predicted for SBG0844 by TMHMM2.0 at aa 10-32 and 41-59 218493004786 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 218493004787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493004788 S-adenosylmethionine binding site [chemical binding]; other site 218493004791 condesin subunit F; Provisional; Region: PRK05260 218493004793 condesin subunit E; Provisional; Region: PRK05256 218493004795 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 218493004796 P-loop containing region of AAA domain; Region: AAA_29; cl17516 218493004797 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 218493004800 murein L,D-transpeptidase; Provisional; Region: PRK10594 218493004801 signal peptide predicted for SBG0849 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.943 between residues 29 and 30 218493004802 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 218493004803 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493004804 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493004808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 218493004809 signal peptide predicted for SBG0850 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 30 and 31 218493004810 Peptidase M15; Region: Peptidase_M15_3; cl01194 218493004811 1 probable transmembrane helix predicted for SBG0850 by TMHMM2.0 at aa 12-34 218493004813 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 218493004815 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 218493004816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493004817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493004818 homodimer interface [polypeptide binding]; other site 218493004819 catalytic residue [active] 218493004822 signal peptide predicted for SBG0853 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493004823 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493004824 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493004825 trimer interface [polypeptide binding]; other site 218493004826 eyelet of channel; other site 218493004829 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 218493004830 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 218493004831 putative dimer interface [polypeptide binding]; other site 218493004832 putative anticodon binding site; other site 218493004833 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 218493004834 homodimer interface [polypeptide binding]; other site 218493004835 motif 1; other site 218493004836 motif 2; other site 218493004837 active site 218493004838 motif 3; other site 218493004843 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 218493004844 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 218493004845 active site 218493004847 MEKHLA domain; Region: MEKHLA; pfam08670 218493004849 aminopeptidase N; Provisional; Region: pepN; PRK14015 218493004850 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 218493004851 active site 218493004852 Zn binding site [ion binding]; other site 218493004855 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 218493004856 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 218493004857 quinone interaction residues [chemical binding]; other site 218493004858 active site 218493004859 catalytic residues [active] 218493004860 FMN binding site [chemical binding]; other site 218493004861 substrate binding site [chemical binding]; other site 218493004865 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 218493004867 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 218493004868 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 218493004869 MOSC domain; Region: MOSC; pfam03473 218493004870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218493004871 catalytic loop [active] 218493004872 iron binding site [ion binding]; other site 218493004877 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 218493004878 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 218493004879 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 218493004880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493004881 S-adenosylmethionine binding site [chemical binding]; other site 218493004887 ABC transporter ATPase component; Reviewed; Region: PRK11147 218493004888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493004890 Walker A/P-loop; other site 218493004891 Walker A/P-loop; other site 218493004892 ATP binding site [chemical binding]; other site 218493004893 ATP binding site [chemical binding]; other site 218493004894 Q-loop/lid; other site 218493004895 Q-loop/lid; other site 218493004896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493004897 ABC transporter signature motif; other site 218493004898 Walker B; other site 218493004899 D-loop; other site 218493004900 ABC transporter; Region: ABC_tran_2; pfam12848 218493004901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493004908 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 218493004909 Paraquat-inducible protein A; Region: PqiA; pfam04403 218493004910 Paraquat-inducible protein A; Region: PqiA; pfam04403 218493004912 8 probable transmembrane helices predicted for SBG0865 by TMHMM2.0 at aa 54-76, 100-122, 135-157,162-184, 255-277, 304-326, 350-372 and 377-399 218493004914 paraquat-inducible protein B; Provisional; Region: PRK10807 218493004915 mce related protein; Region: MCE; pfam02470 218493004916 mce related protein; Region: MCE; pfam02470 218493004917 mce related protein; Region: MCE; pfam02470 218493004918 1 probable transmembrane helix predicted for SBG0866 by TMHMM2.0 at aa 16-38 218493004922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 218493004923 signal peptide predicted for SBG0867 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.878 between residues 19 and 20 218493004924 Protein of unknown function (DUF330); Region: DUF330; pfam03886 218493004927 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 218493004928 active site 1 [active] 218493004929 dimer interface [polypeptide binding]; other site 218493004930 active site 2 [active] 218493004932 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 218493004933 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218493004935 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 218493004937 outer membrane protein A; Reviewed; Region: PRK10808 218493004938 signal peptide predicted for SBG0871 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 21 and 22 218493004939 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 218493004940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218493004941 ligand binding site [chemical binding]; other site 218493004945 cell division inhibitor SulA; Region: sula; TIGR00623 218493004947 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 218493004948 TfoX C-terminal domain; Region: TfoX_C; pfam04994 218493004951 TIGR01666 family membrane protein; Region: YCCS 218493004952 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 218493004953 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218493004955 11 probable transmembrane helices predicted for SBG0874 by TMHMM2.0 at aa 13-35, 40-54, 67-85, 89-108,115-137, 141-163, 400-422, 437-459, 466-483, 488-510 and 517-534 218493004957 Predicted membrane protein [Function unknown]; Region: COG3304 218493004958 Domain of unknown function (DUF307); Region: DUF307; pfam03733 218493004959 Domain of unknown function (DUF307); Region: DUF307; pfam03733 218493004961 3 probable transmembrane helices predicted for SBG0875 by TMHMM2.0 at aa 15-37, 82-104 and 108-130 218493004963 DNA helicase IV; Provisional; Region: helD; PRK11054 218493004964 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 218493004965 Part of AAA domain; Region: AAA_19; pfam13245 218493004966 Family description; Region: UvrD_C_2; pfam13538 218493004970 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 218493004971 active site 218493004972 dimer interfaces [polypeptide binding]; other site 218493004973 catalytic residues [active] 218493004976 hypothetical protein; Provisional; Region: PRK03641 218493004977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 218493004978 signal peptide predicted for SBG0878 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 20 and 21 218493004979 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 218493004982 heat shock protein HspQ; Provisional; Region: PRK14129 218493004984 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 218493004985 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 218493004986 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 218493004987 putative RNA binding site [nucleotide binding]; other site 218493004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493004989 S-adenosylmethionine binding site [chemical binding]; other site 218493004994 signal peptide predicted for SBG0882 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.799 between residues 21 and 22 218493004995 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 218493004996 substrate binding site [chemical binding]; other site 218493004998 Cupin domain; Region: Cupin_2; cl17218 218493004999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493005000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493005003 acylphosphatase; Provisional; Region: PRK14426 218493005007 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 218493005008 sulfur transfer protein TusE; Provisional; Region: PRK11508 218493005010 signal peptide predicted for SBG0886 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.752 between residues 41 and 42 218493005011 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 218493005012 YccA-like proteins; Region: YccA_like; cd10433 218493005014 7 probable transmembrane helices predicted for SBG0886 by TMHMM2.0 at aa 21-40, 45-67, 74-96, 106-125,132-154, 159-181 and 194-216 218493005016 SB100_prophage 218493005017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218493005018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218493005019 active site 218493005020 DNA binding site [nucleotide binding] 218493005021 Int/Topo IB signature motif; other site 218493005023 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 218493005024 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 218493005025 HipA-like N-terminal domain; Region: HipA_N; pfam07805 218493005026 transcriptional repressor DicA; Reviewed; Region: PRK09706 218493005027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493005028 non-specific DNA binding site [nucleotide binding]; other site 218493005029 sequence-specific DNA binding site [nucleotide binding]; other site 218493005030 salt bridge; other site 218493005032 Bacteriophage CII protein; Region: Phage_CII; pfam05269 218493005034 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 218493005036 Replication protein P; Region: Phage_lambda_P; pfam06992 218493005038 1 probable transmembrane helix predicted for SBG0895 by TMHMM2.0 at aa 10-32 218493005039 Protein of unknown function (DUF551); Region: DUF551; pfam04448 218493005041 Arc-like DNA binding domain; Region: Arc; pfam03869 218493005043 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 218493005044 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 218493005045 DinI-like family; Region: DinI; pfam06183 218493005047 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 218493005049 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 218493005052 Ash protein family; Region: Phage_ASH; pfam10554 218493005053 1 probable transmembrane helix predicted for SBG0906 by TMHMM2.0 at aa 36-53 218493005054 ORF6N domain; Region: ORF6N; pfam10543 218493005055 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 218493005057 signal peptide predicted for SBG0911 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.973 between residues 24 and 25 218493005058 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 218493005059 1 probable transmembrane helix predicted for SBG0911 by TMHMM2.0 at aa 7-26 218493005060 signal peptide predicted for SBG0912 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.949 between residues 25 and 26 218493005061 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 218493005064 signal peptide predicted for SBG0913 by SignalP 2.0 HMM (Signal peptide probabilty 0.901) with cleavage site probability 0.363 between residues 22 and 23 218493005065 3 probable transmembrane helices predicted for SBG0913 by TMHMM2.0 at aa 20-42, 54-73 and 88-105 218493005066 Protein of unknown function (DUF754); Region: DUF754; pfam05449 218493005067 3 probable transmembrane helices predicted for SBG0914 by TMHMM2.0 at aa 7-24, 34-56 and 63-85 218493005069 Predicted chitinase [General function prediction only]; Region: COG3179 218493005070 catalytic residue [active] 218493005072 signal peptide predicted for SBG0916 by SignalP 2.0 HMM (Signal peptide probabilty 0.601) with cleavage site probability 0.279 between residues 39 and 40 218493005073 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 218493005074 1 probable transmembrane helix predicted for SBG0916 by TMHMM2.0 at aa 15-37 218493005075 KilA-N domain; Region: KilA-N; pfam04383 218493005078 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 218493005079 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 218493005080 active site 218493005081 2 probable transmembrane helices predicted for SBG0920 by TMHMM2.0 at aa 13-30 and 50-72 218493005083 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 218493005085 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 218493005086 SopA-like central domain; Region: SopA; pfam13981 218493005087 SopA-like catalytic domain; Region: SopA_C; pfam13979 218493005088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 218493005089 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 218493005090 Probable transposase; Region: OrfB_IS605; pfam01385 218493005091 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 218493005096 SB101_Prophage 218493005097 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 218493005099 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 218493005102 1 probable transmembrane helix predicted for SBG0931 by TMHMM2.0 at aa 76-98 218493005103 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 218493005107 1 probable transmembrane helix predicted for SBG0933 by TMHMM2.0 at aa 43-65 218493005108 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 218493005109 SET domain; Region: SET; pfam00856 218493005110 signal peptide predicted for SBG0937 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.836 between residues 23 and 24 218493005112 1 probable transmembrane helix predicted for SBG0937 by TMHMM2.0 at aa 102-124 218493005113 equivalent to part of S. Typhi SPI-5 218493005114 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 218493005116 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 218493005117 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 218493005119 signal peptide predicted for SBG0940 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.606 between residues 19 and 20 218493005120 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 218493005122 signal peptide predicted for SBG0941 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.352 between residues 31 and 32 218493005123 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 218493005124 HAMP domain; Region: HAMP; pfam00672 218493005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493005126 dimer interface [polypeptide binding]; other site 218493005127 phosphorylation site [posttranslational modification] 218493005128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493005129 ATP binding site [chemical binding]; other site 218493005130 Mg2+ binding site [ion binding]; other site 218493005131 G-X-G motif; other site 218493005135 2 probable transmembrane helices predicted for SBG0941 by TMHMM2.0 at aa 10-32 and 162-181 218493005136 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 218493005137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493005138 active site 218493005139 phosphorylation site [posttranslational modification] 218493005140 intermolecular recognition site; other site 218493005141 dimerization interface [polypeptide binding]; other site 218493005142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493005143 DNA binding site [nucleotide binding] 218493005146 signal peptide predicted for SBG0943 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.923 between residues 22 and 23 218493005147 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 218493005148 active site 218493005149 homotetramer interface [polypeptide binding]; other site 218493005150 1 probable transmembrane helix predicted for SBG0943 by TMHMM2.0 at aa 5-24 218493005154 Flavin Reductases; Region: FlaRed; cl00801 218493005156 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 218493005157 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 218493005159 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 218493005160 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218493005163 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 218493005164 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 218493005165 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 218493005168 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 218493005169 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 218493005170 NAD binding site [chemical binding]; other site 218493005171 catalytic residues [active] 218493005175 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 218493005176 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 218493005177 putative active site [active] 218493005178 putative metal binding site [ion binding]; other site 218493005180 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 218493005181 putative substrate binding pocket [chemical binding]; other site 218493005182 trimer interface [polypeptide binding]; other site 218493005184 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 218493005186 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 218493005188 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 218493005189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493005190 putative substrate translocation pore; other site 218493005191 12 probable transmembrane helices predicted for SBG0953 by TMHMM2.0 at aa 32-54, 69-88, 101-123,133-155, 162-184, 194-216, 270-292, 305-327, 340-357,361-383, 396-418 and 428-447 218493005193 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 218493005194 Cupin domain; Region: Cupin_2; pfam07883 218493005195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493005199 signal peptide predicted for SBG0955 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 21 and 22 218493005200 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 218493005202 anti-adapter protein IraM; Provisional; Region: PRK09919 218493005203 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 218493005204 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218493005205 HSP70 interaction site [polypeptide binding]; other site 218493005206 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 218493005207 substrate binding site [polypeptide binding]; other site 218493005208 dimer interface [polypeptide binding]; other site 218493005212 signal peptide predicted for SBG0957 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.394 between residues 28 and 29 218493005213 2 probable transmembrane helices predicted for SBG0957 by TMHMM2.0 at aa 7-29 and 66-88 218493005215 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 218493005216 signal peptide predicted for SBG0958 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 22 and 23 218493005217 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 218493005218 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 218493005219 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 218493005220 DsbD alpha interface [polypeptide binding]; other site 218493005221 catalytic residues [active] 218493005223 6 probable transmembrane helices predicted for SBG0958 by TMHMM2.0 at aa 280-302, 323-345, 360-382,409-431, 436-458 and 479-501 218493005225 signal peptide predicted for SBG0959 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 18 and 19 218493005226 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 218493005227 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 218493005228 catalytic residues [active] 218493005231 signal peptide predicted for SBG0960 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.367 between residues 30 and 31 218493005232 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 218493005233 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218493005234 catalytic residues [active] 218493005235 1 probable transmembrane helix predicted for SBG0960 by TMHMM2.0 at aa 12-31 218493005237 signal peptide predicted for SBG0961 by SignalP 2.0 HMM (Signal peptide probabilty 0.687) with cleavage site probability 0.676 between residues 13 and 14 218493005238 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 218493005239 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 218493005240 catalytic core [active] 218493005241 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 218493005245 hypothetical protein; Provisional; Region: PRK10174 218493005246 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 218493005247 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218493005249 General stress protein [General function prediction only]; Region: GsiB; COG3729 218493005251 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 218493005252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493005253 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 218493005256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 218493005257 signal peptide predicted for SBG0966 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493005259 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 218493005260 Predicted transcriptional regulator [Transcription]; Region: COG3905 218493005261 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 218493005262 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 218493005263 Glutamate binding site [chemical binding]; other site 218493005264 NAD binding site [chemical binding]; other site 218493005265 catalytic residues [active] 218493005270 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218493005271 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 218493005272 Na binding site [ion binding]; other site 218493005273 12 probable transmembrane helices predicted for SBG0968 by TMHMM2.0 at aa 7-26, 66-88, 125-147,162-184, 191-213, 233-255, 276-298, 313-335, 372-391,401-423, 428-450 and 455-473 218493005278 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 218493005279 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 218493005284 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218493005290 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 218493005291 hypothetical protein; Provisional; Region: PRK10536 218493005294 repeat region, 2x repeats, cf 4x repeats in St CT18 218493005295 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 218493005296 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 218493005297 putative ligand binding site [chemical binding]; other site 218493005298 NAD binding site [chemical binding]; other site 218493005299 dimerization interface [polypeptide binding]; other site 218493005300 catalytic site [active] 218493005302 putative hydrolase; Validated; Region: PRK09248 218493005303 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 218493005304 active site 218493005306 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 218493005308 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 218493005309 6 probable transmembrane helices predicted for SBG0976 by TMHMM2.0 at aa 7-29, 33-55, 62-84, 88-110,115-134 and 139-161 218493005313 csg fimbrial operon 218493005314 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 218493005315 signal peptide predicted for SBG0977 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.780 between residues 24 and 25 218493005318 curli assembly protein CsgF; Provisional; Region: PRK10050 218493005319 signal peptide predicted for SBG0978 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.971 between residues 19 and 20 218493005320 1 probable transmembrane helix predicted for SBG0978 by TMHMM2.0 at aa 7-26 218493005321 curli assembly protein CsgE; Provisional; Region: PRK10386 218493005322 signal peptide predicted for SBG0979 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.992 between residues 22 and 23 218493005323 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 218493005324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493005325 DNA binding residues [nucleotide binding] 218493005326 dimerization interface [polypeptide binding]; other site 218493005329 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 218493005330 signal peptide predicted for SBG0981 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.944 between residues 21 and 22 218493005331 Curlin associated repeat; Region: Curlin_rpt; pfam07012 218493005332 Curlin associated repeat; Region: Curlin_rpt; pfam07012 218493005335 major curlin subunit; Provisional; Region: csgA; PRK10051 218493005336 signal peptide predicted for SBG0982 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493005337 Curlin associated repeat; Region: Curlin_rpt; pfam07012 218493005341 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 218493005342 signal peptide predicted for SBG0983 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.910 between residues 17 and 18 218493005343 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 218493005344 putative ADP-ribose binding site [chemical binding]; other site 218493005345 putative active site [active] 218493005347 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 218493005348 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 218493005349 putative active site [active] 218493005350 catalytic site [active] 218493005351 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 218493005352 putative active site [active] 218493005353 catalytic site [active] 218493005356 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 218493005357 Acyltransferase family; Region: Acyl_transf_3; pfam01757 218493005359 10 probable transmembrane helices predicted for SBG0986 by TMHMM2.0 at aa 17-39, 54-76, 88-110,139-161, 174-193, 213-235, 242-261, 276-295, 308-330 and 334-356 218493005360 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 218493005361 signal peptide predicted for SBG0987 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.795 between residues 22 and 23 218493005362 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 218493005364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 218493005365 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 218493005366 Ligand binding site; other site 218493005367 DXD motif; other site 218493005368 6 probable transmembrane helices predicted for SBG0988 by TMHMM2.0 at aa 139-156, 194-216, 512-534,568-590, 603-625 and 680-702 218493005371 signal peptide predicted for SBG0989 by SignalP 2.0 HMM (Signal peptide probabilty 0.810) with cleavage site probability 0.515 between residues 22 and 23 218493005372 lipoprotein; Provisional; Region: PRK10175 218493005375 secY/secA suppressor protein; Provisional; Region: PRK11467 218493005376 drug efflux system protein MdtG; Provisional; Region: PRK09874 218493005377 signal peptide predicted for SBG0991 by SignalP 2.0 HMM (Signal peptide probabilty 0.765) with cleavage site probability 0.605 between residues 29 and 30 218493005378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493005379 putative substrate translocation pore; other site 218493005380 11 probable transmembrane helices predicted for SBG0991 by TMHMM2.0 at aa 15-37, 49-68, 83-101,108-130, 140-162, 169-191, 222-244, 251-273, 288-306,313-335 and 372-394 218493005382 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218493005383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218493005384 putative acyl-acceptor binding pocket; other site 218493005386 1 probable transmembrane helix predicted for SBG0992 by TMHMM2.0 at aa 16-38 218493005387 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 218493005388 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 218493005389 active site residue [active] 218493005392 hypothetical protein; Provisional; Region: PRK03757 218493005394 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 218493005396 4 probable transmembrane helices predicted for SBG0995 by TMHMM2.0 at aa 13-35, 55-74, 95-114 and 147-169 218493005397 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 218493005398 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218493005400 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 218493005401 DNA damage-inducible protein I; Provisional; Region: PRK10597 218493005403 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 218493005404 active site 218493005405 substrate binding pocket [chemical binding]; other site 218493005406 dimer interface [polypeptide binding]; other site 218493005410 lipoprotein; Provisional; Region: PRK10598 218493005411 signal peptide predicted for SBG1001 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.419 between residues 24 and 25 218493005414 glutaredoxin 2; Provisional; Region: PRK10387 218493005415 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 218493005416 C-terminal domain interface [polypeptide binding]; other site 218493005417 GSH binding site (G-site) [chemical binding]; other site 218493005418 catalytic residues [active] 218493005419 putative dimer interface [polypeptide binding]; other site 218493005420 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 218493005421 N-terminal domain interface [polypeptide binding]; other site 218493005425 multidrug resistance protein MdtH; Provisional; Region: PRK11646 218493005426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493005427 putative substrate translocation pore; other site 218493005428 10 probable transmembrane helices predicted for SBG1004 by TMHMM2.0 at aa 13-35, 99-116, 136-158,163-185, 210-232, 247-264, 277-294, 298-315, 335-357 and 367-389 218493005430 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 218493005431 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218493005433 hypothetical protein; Provisional; Region: PRK11239 218493005434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 218493005437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218493005438 signal peptide predicted for SBG1007 by SignalP 2.0 HMM (Signal peptide probabilty 0.798) with cleavage site probability 0.585 between residues 24 and 25 218493005439 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218493005440 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218493005444 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 218493005445 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 218493005447 12 probable transmembrane helices predicted for SBG1008 by TMHMM2.0 at aa 68-90, 116-138, 145-167,172-189, 223-245, 260-282, 295-314, 334-356, 369-388,393-415, 427-449 and 464-486 218493005449 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 218493005451 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 218493005453 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 218493005454 signal peptide predicted for SBG1011 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 21 and 22 218493005455 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 218493005456 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 218493005458 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 218493005459 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 218493005462 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 218493005463 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218493005464 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218493005468 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 218493005469 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 218493005470 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 218493005472 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 218493005473 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218493005474 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 218493005475 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218493005480 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 218493005481 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218493005482 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 218493005486 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 218493005487 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218493005488 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218493005492 signal peptide predicted for SBG1018 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.274 between residues 40 and 41 218493005493 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 218493005494 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 218493005495 1 probable transmembrane helix predicted for SBG1018 by TMHMM2.0 at aa 7-29 218493005498 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 218493005499 signal peptide predicted for SBG1019 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 21 and 22 218493005500 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 218493005502 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 218493005503 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 218493005504 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 218493005506 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 218493005507 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218493005511 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 218493005512 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 218493005514 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218493005515 signal peptide predicted for SBG1023 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.597 between residues 29 and 30 218493005516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493005517 putative substrate translocation pore; other site 218493005518 10 probable transmembrane helices predicted for SBG1023 by TMHMM2.0 at aa 7-29, 44-66, 87-109,139-161, 168-190, 215-237, 244-266, 281-300, 342-364 and 368-390 218493005521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493005522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493005523 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218493005524 putative effector binding pocket; other site 218493005525 dimerization interface [polypeptide binding]; other site 218493005529 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 218493005530 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218493005531 homodimer interface [polypeptide binding]; other site 218493005532 oligonucleotide binding site [chemical binding]; other site 218493005533 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 218493005536 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 218493005537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493005538 RNA binding surface [nucleotide binding]; other site 218493005539 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218493005540 active site 218493005544 Maf-like protein; Region: Maf; pfam02545 218493005545 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218493005546 active site 218493005547 dimer interface [polypeptide binding]; other site 218493005549 hypothetical protein; Provisional; Region: PRK11193 218493005551 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 218493005553 putative phosphate acyltransferase; Provisional; Region: PRK05331 218493005555 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 218493005556 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218493005557 dimer interface [polypeptide binding]; other site 218493005558 active site 218493005559 CoA binding pocket [chemical binding]; other site 218493005562 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 218493005563 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218493005565 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218493005566 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 218493005567 NAD(P) binding site [chemical binding]; other site 218493005568 homotetramer interface [polypeptide binding]; other site 218493005569 homodimer interface [polypeptide binding]; other site 218493005570 active site 218493005573 acyl carrier protein; Provisional; Region: acpP; PRK00982 218493005577 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 218493005578 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218493005579 dimer interface [polypeptide binding]; other site 218493005580 active site 218493005584 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218493005585 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 218493005586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493005587 catalytic residue [active] 218493005590 conserved hypothetical protein, YceG family; Region: TIGR00247 218493005591 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 218493005592 dimerization interface [polypeptide binding]; other site 218493005594 thymidylate kinase; Validated; Region: tmk; PRK00698 218493005595 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 218493005596 TMP-binding site; other site 218493005597 ATP-binding site [chemical binding]; other site 218493005601 DNA polymerase III subunit delta'; Validated; Region: PRK07993 218493005602 DNA polymerase III subunit delta'; Validated; Region: PRK08485 218493005603 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 218493005605 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218493005606 active site 218493005610 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 218493005611 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218493005612 signal peptide predicted for SBG1041 by SignalP 2.0 HMM (Signal peptide probabilty 0.822) with cleavage site probability 0.390 between residues 49 and 50 218493005613 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493005614 active site turn [active] 218493005615 phosphorylation site [posttranslational modification] 218493005617 9 probable transmembrane helices predicted for SBG1041 by TMHMM2.0 at aa 15-37, 49-71, 81-103, 116-138,153-175, 248-270, 280-302, 309-331 and 354-376 218493005620 signal peptide predicted for SBG1042 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.970 between residues 36 and 37 218493005621 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 218493005622 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493005623 N-terminal plug; other site 218493005624 ligand-binding site [chemical binding]; other site 218493005629 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 218493005630 nucleotide binding site/active site [active] 218493005631 HIT family signature motif; other site 218493005632 catalytic residue [active] 218493005635 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 218493005636 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 218493005637 putative dimer interface [polypeptide binding]; other site 218493005640 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 218493005641 signal peptide predicted for SBG1045 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.496 between residues 21 and 22 218493005643 thiamine kinase; Region: ycfN_thiK; TIGR02721 218493005644 thiamine kinase; Provisional; Region: thiK; PRK10271 218493005645 substrate binding site [chemical binding]; other site 218493005648 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 218493005649 beta-hexosaminidase; Provisional; Region: PRK05337 218493005652 hypothetical protein; Provisional; Region: PRK04940 218493005654 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 218493005655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493005658 signal peptide predicted for SBG1050 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.574 between residues 23 and 24 218493005659 hypothetical protein; Provisional; Region: PRK11280 218493005660 1 probable transmembrane helix predicted for SBG1050 by TMHMM2.0 at aa 5-27 218493005662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218493005663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493005665 signal peptide predicted for SBG1052 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.960 between residues 22 and 23 218493005666 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493005668 1 probable transmembrane helix predicted for SBG1052 by TMHMM2.0 at aa 7-29 218493005669 signal peptide predicted for SBG1053 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.967 between residues 28 and 29 218493005670 L,D-transpeptidase; Provisional; Region: PRK10260 218493005671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493005672 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493005675 1 probable transmembrane helix predicted for SBG1053 by TMHMM2.0 at aa 7-29 218493005676 transcription-repair coupling factor; Provisional; Region: PRK10689 218493005677 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 218493005678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493005679 ATP binding site [chemical binding]; other site 218493005680 putative Mg++ binding site [ion binding]; other site 218493005681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493005682 nucleotide binding region [chemical binding]; other site 218493005683 ATP-binding site [chemical binding]; other site 218493005684 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 218493005690 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 218493005691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218493005692 FtsX-like permease family; Region: FtsX; pfam02687 218493005693 4 probable transmembrane helices predicted for SBG1055 by TMHMM2.0 at aa 25-47, 266-288, 318-340 and 360-382 218493005695 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 218493005696 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218493005697 Walker A/P-loop; other site 218493005698 ATP binding site [chemical binding]; other site 218493005699 Q-loop/lid; other site 218493005700 ABC transporter signature motif; other site 218493005701 Walker B; other site 218493005702 D-loop; other site 218493005703 H-loop/switch region; other site 218493005707 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 218493005708 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218493005709 FtsX-like permease family; Region: FtsX; pfam02687 218493005710 4 probable transmembrane helices predicted for SBG1057 by TMHMM2.0 at aa 21-43, 270-292, 319-341 and 375-397 218493005714 fructokinase; Reviewed; Region: PRK09557 218493005715 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493005716 nucleotide binding site [chemical binding]; other site 218493005720 NAD-dependent deacetylase; Provisional; Region: PRK00481 218493005721 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 218493005722 NAD+ binding site [chemical binding]; other site 218493005723 substrate binding site [chemical binding]; other site 218493005724 Zn binding site [ion binding]; other site 218493005726 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 218493005727 signal peptide predicted for SBG1060 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493005728 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 218493005730 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218493005731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493005732 dimer interface [polypeptide binding]; other site 218493005733 conserved gate region; other site 218493005734 putative PBP binding loops; other site 218493005735 ABC-ATPase subunit interface; other site 218493005737 5 probable transmembrane helices predicted for SBG1061 by TMHMM2.0 at aa 38-60, 73-95, 100-122, 150-169 and 204-226 218493005739 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218493005740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493005741 dimer interface [polypeptide binding]; other site 218493005742 conserved gate region; other site 218493005743 putative PBP binding loops; other site 218493005744 ABC-ATPase subunit interface; other site 218493005746 6 probable transmembrane helices predicted for SBG1062 by TMHMM2.0 at aa 9-31, 69-91, 98-120, 151-173,194-216 and 250-272 218493005750 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 218493005751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493005752 Walker A/P-loop; other site 218493005753 ATP binding site [chemical binding]; other site 218493005754 Q-loop/lid; other site 218493005755 ABC transporter signature motif; other site 218493005756 Walker B; other site 218493005757 D-loop; other site 218493005758 H-loop/switch region; other site 218493005759 TOBE domain; Region: TOBE_2; pfam08402 218493005764 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 218493005765 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 218493005766 metal binding site [ion binding]; metal-binding site 218493005767 dimer interface [polypeptide binding]; other site 218493005772 Uncharacterized conserved protein [Function unknown]; Region: COG2850 218493005773 Cupin-like domain; Region: Cupin_8; pfam13621 218493005775 signal peptide predicted for SBG1066 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.302 between residues 31 and 32 218493005776 sensor protein PhoQ; Provisional; Region: PRK10815 218493005777 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 218493005778 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 218493005779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493005780 ATP binding site [chemical binding]; other site 218493005781 Mg2+ binding site [ion binding]; other site 218493005782 G-X-G motif; other site 218493005786 2 probable transmembrane helices predicted for SBG1066 by TMHMM2.0 at aa 20-42 and 194-216 218493005788 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 218493005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493005790 active site 218493005791 phosphorylation site [posttranslational modification] 218493005792 intermolecular recognition site; other site 218493005793 dimerization interface [polypeptide binding]; other site 218493005794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493005795 DNA binding site [nucleotide binding] 218493005798 adenylosuccinate lyase; Provisional; Region: PRK09285 218493005799 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 218493005800 tetramer interface [polypeptide binding]; other site 218493005801 active site 218493005805 putative lysogenization regulator; Reviewed; Region: PRK00218 218493005807 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 218493005808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 218493005811 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 218493005812 nudix motif; other site 218493005815 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 218493005816 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 218493005817 probable active site [active] 218493005820 isocitrate dehydrogenase; Validated; Region: PRK07362 218493005821 isocitrate dehydrogenase; Reviewed; Region: PRK07006 218493005824 signal peptide predicted for SBG1075 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 27 and 28 218493005825 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 218493005826 Beta-lactamase; Region: Beta-lactamase; pfam00144 218493005827 Domain of unknown function DUF302; Region: DUF302; cl01364 218493005830 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 218493005831 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 218493005840 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 218493005841 signal peptide predicted for SBG1077 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 21 and 22 218493005844 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 218493005845 signal peptide predicted for SBG1078 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.976 between residues 18 and 19 218493005848 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 218493005849 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 218493005850 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 218493005852 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 218493005854 signal peptide predicted for SBG1081 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.840 between residues 22 and 23 218493005855 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 218493005856 putative catalytic site [active] 218493005857 CdtC interface [polypeptide binding]; other site 218493005858 heterotrimer interface [polypeptide binding]; other site 218493005859 CdtA interface [polypeptide binding]; other site 218493005860 putative metal binding site [ion binding]; other site 218493005861 putative phosphate binding site [ion binding]; other site 218493005864 1 probable transmembrane helix predicted for SBG1081 by TMHMM2.0 at aa 5-24 218493005865 Salmonella outer protein D; Region: SopD; cl14701 218493005866 SET domain; Region: SET; pfam00856 218493005867 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 218493005868 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 218493005869 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 218493005870 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 218493005871 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218493005872 1 probable transmembrane helix predicted for SBG1083 by TMHMM2.0 at aa 38-60 218493005875 DinI-like family; Region: DinI; pfam06183 218493005877 signal peptide predicted for SBG1085 by SignalP 2.0 HMM (Signal peptide probabilty 0.930) with cleavage site probability 0.674 between residues 25 and 26 218493005878 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 218493005879 putative sugar binding sites [chemical binding]; other site 218493005880 Q-X-W motif; other site 218493005881 Ricin-type beta-trefoil; Region: RICIN; smart00458 218493005882 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 218493005885 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 218493005886 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 218493005887 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 218493005888 Leucine rich repeat; Region: LRR_8; pfam13855 218493005897 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493005898 DNA-binding site [nucleotide binding]; DNA binding site 218493005899 RNA-binding motif; other site 218493005901 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 218493005902 signal peptide predicted for SBG1090 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 23 and 24 218493005906 lysozyme inhibitor; Provisional; Region: PRK13791 218493005907 signal peptide predicted for SBG1092 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.913 between residues 23 and 24 218493005908 1 probable transmembrane helix predicted for SBG1093 by TMHMM2.0 at aa 5-24 218493005910 This CDS is highly degenerate with premature stop codons and frameshift mutations 218493005911 2 probable transmembrane helices predicted for SBG1094 by TMHMM2.0 at aa 9-31 and 69-88 218493005912 signal peptide predicted for SBG1094 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 40 and 41 218493005913 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 218493005914 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 218493005915 putative dimer interface [polypeptide binding]; other site 218493005919 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 218493005920 signal peptide predicted for SBG1097 by SignalP 2.0 HMM (Signal peptide probabilty 0.844) with cleavage site probability 0.839 between residues 24 and 25 218493005922 4 probable transmembrane helices predicted for SBG1097 by TMHMM2.0 at aa 9-31, 46-63, 88-110 and 140-162 218493005923 signal peptide predicted for SBG1098 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.403 between residues 23 and 24 218493005924 TRL-like protein family; Region: TRL; pfam13146 218493005925 1 probable transmembrane helix predicted for SBG1098 by TMHMM2.0 at aa 7-29 218493005927 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 218493005928 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218493005930 signal peptide predicted for SBG1102 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.438 between residues 29 and 30 218493005931 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218493005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493005933 dimer interface [polypeptide binding]; other site 218493005934 conserved gate region; other site 218493005935 putative PBP binding loops; other site 218493005936 ABC-ATPase subunit interface; other site 218493005937 4 probable transmembrane helices predicted for SBG1102 by TMHMM2.0 at aa 7-29, 104-126, 139-161 and 292-314 218493005939 signal peptide predicted for SBG1103 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.858 between residues 28 and 29 218493005940 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218493005941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493005942 dimer interface [polypeptide binding]; other site 218493005943 conserved gate region; other site 218493005944 putative PBP binding loops; other site 218493005945 ABC-ATPase subunit interface; other site 218493005946 4 probable transmembrane helices predicted for SBG1103 by TMHMM2.0 at aa 7-29, 74-96, 117-139 and 236-253 218493005948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493005949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218493005950 Walker A/P-loop; other site 218493005951 ATP binding site [chemical binding]; other site 218493005952 Q-loop/lid; other site 218493005953 ABC transporter signature motif; other site 218493005954 Walker B; other site 218493005955 D-loop; other site 218493005956 H-loop/switch region; other site 218493005959 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 218493005960 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493005961 Walker A/P-loop; other site 218493005962 ATP binding site [chemical binding]; other site 218493005963 Q-loop/lid; other site 218493005964 ABC transporter signature motif; other site 218493005965 Walker B; other site 218493005966 D-loop; other site 218493005967 H-loop/switch region; other site 218493005971 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 218493005972 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493005974 5 probable transmembrane helices predicted for SBG1106 by TMHMM2.0 at aa 20-42, 74-90, 97-114, 136-158 and 165-187 218493005975 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 218493005976 dimerization interface [polypeptide binding]; other site 218493005981 zinc/cadmium-binding protein; Provisional; Region: PRK10306 218493005982 signal peptide predicted for SBG1108 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.507 between residues 30 and 31 218493005985 aminoglycoside resistance protein; Provisional; Region: PRK13746 218493005986 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 218493005987 active site 218493005988 NTP binding site [chemical binding]; other site 218493005989 metal binding triad [ion binding]; metal-binding site 218493005990 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 218493005992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493005993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493005994 DNA binding residues [nucleotide binding] 218493005996 transcriptional regulator MirA; Provisional; Region: PRK15043 218493005997 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 218493005998 DNA binding residues [nucleotide binding] 218493005999 dimer interface [polypeptide binding]; other site 218493006001 Pleckstrin homology-like domain; Region: PH-like; cl17171 218493006002 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 218493006003 signal peptide predicted for SBG1113 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 20 and 21 218493006004 chorismate mutase; Provisional; Region: PRK08055 218493006006 signal peptide predicted for SBG1114 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.807 between residues 23 and 24 218493006007 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 218493006008 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493006009 substrate binding pocket [chemical binding]; other site 218493006010 membrane-bound complex binding site; other site 218493006011 hinge residues; other site 218493006013 leucine export protein LeuE; Provisional; Region: PRK10958 218493006014 6 probable transmembrane helices predicted for SBG1115 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142,157-179 and 191-210 218493006016 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 218493006018 signal peptide predicted for SBG1117 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.632 between residues 27 and 28 218493006019 6 probable transmembrane helices predicted for SBG1117 by TMHMM2.0 at aa 9-31, 46-65, 72-91, 101-123,136-153 and 179-196 218493006022 1 probable transmembrane helix predicted for SBG1118 by TMHMM2.0 at aa 28-50 218493006023 hypothetical protein; Provisional; Region: PRK10457 218493006024 3 probable transmembrane helices predicted for SBG1119 by TMHMM2.0 at aa 4-21, 28-50 and 60-77 218493006026 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 218493006027 signal peptide predicted for SBG1120 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.964 between residues 21 and 22 218493006028 Domain of unknown function (DUF333); Region: DUF333; pfam03891 218493006032 Uncharacterized conserved protein [Function unknown]; Region: COG3189 218493006034 signal peptide predicted for SBG1123 by SignalP 2.0 HMM (Signal peptide probabilty 0.919) with cleavage site probability 0.585 between residues 33 and 34 218493006035 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 218493006036 12 probable transmembrane helices predicted for SBG1123 by TMHMM2.0 at aa 12-31, 46-68, 81-98,103-125, 137-159, 163-185, 212-234, 249-271, 278-297,302-324, 333-355 and 365-387 218493006040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493006041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493006044 Predicted membrane protein [Function unknown]; Region: COG2707 218493006045 signal peptide predicted for SBG1125 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.539 between residues 24 and 25 218493006047 4 probable transmembrane helices predicted for SBG1125 by TMHMM2.0 at aa 12-34, 49-71, 78-100 and 124-146 218493006048 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 218493006049 putative deacylase active site [active] 218493006051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218493006052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493006053 metal binding site [ion binding]; metal-binding site 218493006054 active site 218493006055 I-site; other site 218493006057 2 probable transmembrane helices predicted for SBG1127 by TMHMM2.0 at aa 7-29 and 305-327 218493006058 signal peptide predicted for SBG1128 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 44 and 45 218493006059 1 probable transmembrane helix predicted for SBG1128 by TMHMM2.0 at aa 25-47 218493006060 hypothetical protein; Provisional; Region: PRK05325 218493006062 PrkA family serine protein kinase; Provisional; Region: PRK15455 218493006063 AAA ATPase domain; Region: AAA_16; pfam13191 218493006064 Walker A motif; other site 218493006065 ATP binding site [chemical binding]; other site 218493006066 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 218493006070 signal peptide predicted for SBG1131 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 between residues 22 and 23 218493006071 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 218493006073 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 218493006074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493006075 FeS/SAM binding site; other site 218493006076 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 218493006078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493006079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493006080 active site 218493006081 catalytic tetrad [active] 218493006083 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 218493006084 active site 218493006085 phosphate binding residues; other site 218493006086 catalytic residues [active] 218493006089 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 218493006090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 218493006091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218493006095 methionine sulfoxide reductase B; Provisional; Region: PRK00222 218493006096 SelR domain; Region: SelR; pfam01641 218493006098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 218493006100 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493006101 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 218493006102 putative NAD(P) binding site [chemical binding]; other site 218493006103 catalytic Zn binding site [ion binding]; other site 218493006104 structural Zn binding site [ion binding]; other site 218493006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006110 12 probable transmembrane helices predicted for SBG1139 by TMHMM2.0 at aa 25-47, 60-82, 89-108,112-134, 154-176, 180-202, 266-288, 301-323, 330-352,356-378, 391-413 and 418-440 218493006113 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 218493006114 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493006115 inhibitor binding site; inhibition site 218493006116 catalytic Zn binding site [ion binding]; other site 218493006117 structural Zn binding site [ion binding]; other site 218493006118 NADP binding site [chemical binding]; other site 218493006119 tetramer interface [polypeptide binding]; other site 218493006125 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 218493006126 intersubunit interface [polypeptide binding]; other site 218493006127 active site 218493006128 zinc binding site [ion binding]; other site 218493006129 Na+ binding site [ion binding]; other site 218493006131 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218493006132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493006133 substrate binding site [chemical binding]; other site 218493006134 ATP binding site [chemical binding]; other site 218493006139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493006140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493006141 active site 218493006142 catalytic tetrad [active] 218493006144 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493006145 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493006146 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493006150 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 218493006151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006152 putative substrate translocation pore; other site 218493006153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006154 12 probable transmembrane helices predicted for SBG1145 by TMHMM2.0 at aa 21-43, 58-80, 93-115,119-141, 153-175, 179-198, 266-288, 298-320, 327-344,354-376, 389-411 and 416-438 218493006156 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 218493006157 Isochorismatase family; Region: Isochorismatase; pfam00857 218493006158 catalytic triad [active] 218493006159 metal binding site [ion binding]; metal-binding site 218493006160 conserved cis-peptide bond; other site 218493006162 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 218493006163 active site 218493006164 homodimer interface [polypeptide binding]; other site 218493006168 protease 4; Provisional; Region: PRK10949 218493006169 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 218493006170 tandem repeat interface [polypeptide binding]; other site 218493006171 oligomer interface [polypeptide binding]; other site 218493006172 active site residues [active] 218493006173 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 218493006174 tandem repeat interface [polypeptide binding]; other site 218493006175 oligomer interface [polypeptide binding]; other site 218493006176 active site residues [active] 218493006179 1 probable transmembrane helix predicted for SBG1148 by TMHMM2.0 at aa 21-43 218493006180 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 218493006181 putative FMN binding site [chemical binding]; other site 218493006183 selenophosphate synthetase; Provisional; Region: PRK00943 218493006184 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 218493006185 dimerization interface [polypeptide binding]; other site 218493006186 putative ATP binding site [chemical binding]; other site 218493006190 DNA topoisomerase III; Provisional; Region: PRK07726 218493006191 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 218493006192 active site 218493006193 putative interdomain interaction site [polypeptide binding]; other site 218493006194 putative metal-binding site [ion binding]; other site 218493006195 putative nucleotide binding site [chemical binding]; other site 218493006196 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218493006197 domain I; other site 218493006198 DNA binding groove [nucleotide binding] 218493006199 phosphate binding site [ion binding]; other site 218493006200 domain II; other site 218493006201 domain III; other site 218493006202 nucleotide binding site [chemical binding]; other site 218493006203 catalytic site [active] 218493006204 domain IV; other site 218493006208 glutamate dehydrogenase; Provisional; Region: PRK09414 218493006209 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 218493006210 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 218493006211 NAD(P) binding site [chemical binding]; other site 218493006215 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 218493006217 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 218493006218 active site 218493006219 8-oxo-dGMP binding site [chemical binding]; other site 218493006220 nudix motif; other site 218493006221 metal binding site [ion binding]; metal-binding site 218493006224 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 218493006225 putative catalytic site [active] 218493006226 putative phosphate binding site [ion binding]; other site 218493006227 active site 218493006228 metal binding site A [ion binding]; metal-binding site 218493006229 DNA binding site [nucleotide binding] 218493006230 putative AP binding site [nucleotide binding]; other site 218493006231 putative metal binding site B [ion binding]; other site 218493006234 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 218493006235 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493006236 inhibitor-cofactor binding pocket; inhibition site 218493006237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493006238 catalytic residue [active] 218493006241 arginine succinyltransferase; Provisional; Region: PRK10456 218493006242 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 218493006244 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 218493006245 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 218493006246 NAD(P) binding site [chemical binding]; other site 218493006247 catalytic residues [active] 218493006251 succinylarginine dihydrolase; Provisional; Region: PRK13281 218493006253 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 218493006254 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 218493006255 putative active site [active] 218493006256 Zn binding site [ion binding]; other site 218493006258 1 probable transmembrane helix predicted for SBG1161 by TMHMM2.0 at aa 10-32 218493006259 signal peptide predicted for SBG1162 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 23 and 24 218493006260 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218493006261 dimer interface [polypeptide binding]; other site 218493006264 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 218493006265 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 218493006266 GIY-YIG motif/motif A; other site 218493006267 active site 218493006268 catalytic site [active] 218493006269 putative DNA binding site [nucleotide binding]; other site 218493006270 metal binding site [ion binding]; metal-binding site 218493006272 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 218493006273 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 218493006274 homodimer interface [polypeptide binding]; other site 218493006275 NAD binding pocket [chemical binding]; other site 218493006276 ATP binding pocket [chemical binding]; other site 218493006277 Mg binding site [ion binding]; other site 218493006278 active-site loop [active] 218493006280 signal peptide predicted for SBG1165 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.906 between residues 23 and 24 218493006281 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 218493006282 1 probable transmembrane helix predicted for SBG1165 by TMHMM2.0 at aa 5-24 218493006285 signal peptide predicted for SBG1166 by SignalP 2.0 HMM (Signal peptide probabilty 0.690) with cleavage site probability 0.227 between residues 27 and 28 218493006286 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218493006287 active site 218493006288 P-loop; other site 218493006289 phosphorylation site [posttranslational modification] 218493006291 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 218493006292 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 218493006294 10 probable transmembrane helices predicted for SBG1167 by TMHMM2.0 at aa 31-53, 85-107, 114-133,143-165, 186-208, 232-254, 302-321, 341-363, 370-392 and 407-429 218493006296 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218493006297 methionine cluster; other site 218493006298 active site 218493006299 phosphorylation site [posttranslational modification] 218493006300 metal binding site [ion binding]; metal-binding site 218493006302 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 218493006303 Cupin domain; Region: Cupin_2; pfam07883 218493006304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493006308 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 218493006309 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 218493006310 NAD binding site [chemical binding]; other site 218493006311 sugar binding site [chemical binding]; other site 218493006312 divalent metal binding site [ion binding]; other site 218493006313 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218493006314 dimer interface [polypeptide binding]; other site 218493006317 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 218493006318 putative active site [active] 218493006319 YdjC motif; other site 218493006320 Mg binding site [ion binding]; other site 218493006321 putative homodimer interface [polypeptide binding]; other site 218493006323 hydroperoxidase II; Provisional; Region: katE; PRK11249 218493006324 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 218493006325 tetramer interface [polypeptide binding]; other site 218493006326 heme binding pocket [chemical binding]; other site 218493006327 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 218493006328 domain interactions; other site 218493006333 cell division modulator; Provisional; Region: PRK10113 218493006334 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 218493006335 signal peptide predicted for SBG1174 by SignalP 2.0 HMM (Signal peptide probabilty 0.873) with cleavage site probability 0.440 between residues 25 and 26 218493006336 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218493006338 9 probable transmembrane helices predicted for SBG1174 by TMHMM2.0 at aa 5-22, 34-51, 71-93, 105-127,180-202, 260-282, 340-362, 369-391 and 395-417 218493006339 inner membrane protein; Provisional; Region: PRK11648 218493006341 2 probable transmembrane helices predicted for SBG1175 by TMHMM2.0 at aa 72-94 and 109-131 218493006342 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 218493006343 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218493006344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493006345 motif II; other site 218493006347 YniB-like protein; Region: YniB; pfam14002 218493006348 3 probable transmembrane helices predicted for SBG1177 by TMHMM2.0 at aa 16-38, 81-100 and 150-172 218493006349 Phosphotransferase enzyme family; Region: APH; pfam01636 218493006350 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 218493006351 active site 218493006352 ATP binding site [chemical binding]; other site 218493006353 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 218493006355 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 218493006356 6-phosphofructokinase 2; Provisional; Region: PRK10294 218493006357 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 218493006358 putative substrate binding site [chemical binding]; other site 218493006359 putative ATP binding site [chemical binding]; other site 218493006363 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 218493006364 signal peptide predicted for SBG1181 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.878 between residues 25 and 26 218493006366 signal peptide predicted for SBG1182 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.765 between residues 23 and 24 218493006367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 218493006368 signal peptide predicted for SBG1183 by SignalP 2.0 HMM (Signal peptide probabilty 0.968) with cleavage site probability 0.769 between residues 25 and 26 218493006369 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 218493006370 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 218493006371 active site 218493006372 substrate binding site [chemical binding]; other site 218493006373 Mg2+ binding site [ion binding]; other site 218493006376 Represents the very 5' region of what appears to be a gene remnant 218493006377 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 218493006378 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 218493006379 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 218493006380 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 218493006381 active site 218493006382 dimer interface [polypeptide binding]; other site 218493006383 motif 1; other site 218493006384 motif 2; other site 218493006385 motif 3; other site 218493006386 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 218493006387 anticodon binding site; other site 218493006394 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 218493006395 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 218493006396 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 218493006400 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 218493006403 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 218493006404 23S rRNA binding site [nucleotide binding]; other site 218493006405 L21 binding site [polypeptide binding]; other site 218493006406 L13 binding site [polypeptide binding]; other site 218493006409 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 218493006410 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 218493006411 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 218493006412 dimer interface [polypeptide binding]; other site 218493006413 motif 1; other site 218493006414 active site 218493006415 motif 2; other site 218493006416 motif 3; other site 218493006421 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 218493006422 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218493006423 putative tRNA-binding site [nucleotide binding]; other site 218493006424 B3/4 domain; Region: B3_4; pfam03483 218493006425 tRNA synthetase B5 domain; Region: B5; smart00874 218493006426 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 218493006427 dimer interface [polypeptide binding]; other site 218493006428 motif 1; other site 218493006429 motif 3; other site 218493006430 motif 2; other site 218493006431 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 218493006437 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218493006438 IHF dimer interface [polypeptide binding]; other site 218493006439 IHF - DNA interface [nucleotide binding]; other site 218493006442 signal peptide predicted for SBG1192 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.781 between residues 33 and 34 218493006443 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218493006444 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493006445 ABC-ATPase subunit interface; other site 218493006446 dimer interface [polypeptide binding]; other site 218493006447 putative PBP binding regions; other site 218493006448 9 probable transmembrane helices predicted for SBG1192 by TMHMM2.0 at aa 17-39, 59-81, 88-107, 111-133,146-168, 188-205, 242-264, 274-296 and 303-322 218493006450 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 218493006451 catalytic residues [active] 218493006452 dimer interface [polypeptide binding]; other site 218493006456 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 218493006457 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218493006458 Walker A/P-loop; other site 218493006459 ATP binding site [chemical binding]; other site 218493006460 Q-loop/lid; other site 218493006461 ABC transporter signature motif; other site 218493006462 Walker B; other site 218493006463 D-loop; other site 218493006464 H-loop/switch region; other site 218493006468 signal peptide predicted for SBG1195 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.764 between residues 20 and 21 218493006469 NlpC/P60 family; Region: NLPC_P60; pfam00877 218493006472 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 218493006473 Uncharacterized conserved protein [Function unknown]; Region: COG0397 218493006474 hypothetical protein; Validated; Region: PRK00029 218493006476 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 218493006477 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 218493006478 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218493006480 PEP synthetase regulatory protein; Provisional; Region: PRK05339 218493006483 phosphoenolpyruvate synthase; Validated; Region: PRK06464 218493006484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 218493006485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218493006486 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218493006492 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 218493006493 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 218493006494 active site 218493006495 catalytic residue [active] 218493006496 dimer interface [polypeptide binding]; other site 218493006499 putative inner membrane protein; Provisional; Region: PRK10983 218493006500 signal peptide predicted for SBG1203 by SignalP 2.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.892 between residues 41 and 42 218493006501 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218493006503 8 probable transmembrane helices predicted for SBG1203 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 159-181,202-224, 237-259, 266-288 and 308-330 218493006506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 218493006507 FAD binding domain; Region: FAD_binding_4; pfam01565 218493006508 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 218493006514 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218493006515 CoenzymeA binding site [chemical binding]; other site 218493006516 subunit interaction site [polypeptide binding]; other site 218493006517 PHB binding site; other site 218493006519 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 218493006520 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218493006522 11 probable transmembrane helices predicted for SBG1208 by TMHMM2.0 at aa 5-22, 29-51, 66-88, 101-123,170-192, 220-242, 252-274, 286-308, 336-353, 358-380 and 384-406 218493006524 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 218493006526 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 218493006527 putative ABC transporter; Region: ycf24; CHL00085 218493006529 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 218493006530 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 218493006531 Walker A/P-loop; other site 218493006532 ATP binding site [chemical binding]; other site 218493006533 Q-loop/lid; other site 218493006534 ABC transporter signature motif; other site 218493006535 Walker B; other site 218493006536 D-loop; other site 218493006537 H-loop/switch region; other site 218493006541 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 218493006542 FeS assembly protein SufD; Region: sufD; TIGR01981 218493006544 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 218493006545 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218493006546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218493006547 catalytic residue [active] 218493006550 cysteine desufuration protein SufE; Provisional; Region: PRK09296 218493006552 signal peptide predicted for SBG1215 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.695 between residues 23 and 24 218493006553 L,D-transpeptidase; Provisional; Region: PRK10190 218493006554 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493006555 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493006558 murein lipoprotein; Provisional; Region: PRK15396 218493006559 signal peptide predicted for SBG1216 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.923 between residues 25 and 26 218493006563 pyruvate kinase; Provisional; Region: PRK09206 218493006564 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 218493006565 domain interfaces; other site 218493006566 active site 218493006570 the tetrathionate respiration region 218493006571 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 218493006572 13 probable transmembrane helices predicted for SBG1218 by TMHMM2.0 at aa 10-32, 39-61, 71-93, 95-114,119-138, 147-169, 184-206, 227-249, 272-294, 330-347,357-379, 386-405 and 409-428 218493006574 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 218493006576 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 218493006579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493006580 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493006581 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493006582 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 218493006583 substrate binding site [chemical binding]; other site 218493006584 dimer interface [polypeptide binding]; other site 218493006585 ATP binding site [chemical binding]; other site 218493006589 signal peptide predicted for SBG1222 by SignalP 2.0 HMM (Signal peptide probabilty 0.685) with cleavage site probability 0.627 between residues 27 and 28 218493006590 tetrathionate reductase subunit A; Provisional; Region: PRK14991 218493006591 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 218493006592 putative [Fe4-S4] binding site [ion binding]; other site 218493006593 putative molybdopterin cofactor binding site [chemical binding]; other site 218493006594 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 218493006595 putative molybdopterin cofactor binding site; other site 218493006599 tetrathionate reductase subunit C; Provisional; Region: PRK14992 218493006600 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 218493006601 9 probable transmembrane helices predicted for SBG1223 by TMHMM2.0 at aa 23-45, 58-77, 92-114, 126-148,163-185, 192-214, 238-260, 267-289 and 309-326 218493006604 tetrathionate reductase subunit B; Provisional; Region: PRK14993 218493006605 4Fe-4S binding domain; Region: Fer4; pfam00037 218493006608 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 218493006609 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 218493006610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218493006611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493006612 dimer interface [polypeptide binding]; other site 218493006613 phosphorylation site [posttranslational modification] 218493006614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493006615 ATP binding site [chemical binding]; other site 218493006616 Mg2+ binding site [ion binding]; other site 218493006617 G-X-G motif; other site 218493006618 1 probable transmembrane helix predicted for SBG1225 by TMHMM2.0 at aa 272-294 218493006621 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 218493006622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493006623 active site 218493006624 phosphorylation site [posttranslational modification] 218493006625 intermolecular recognition site; other site 218493006626 dimerization interface [polypeptide binding]; other site 218493006627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493006628 DNA binding residues [nucleotide binding] 218493006629 dimerization interface [polypeptide binding]; other site 218493006633 hypothetical protein; Provisional; Region: PRK10292 218493006634 additional CDS wrt S. Typhi SPI-2 218493006635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493006636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493006637 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218493006638 putative effector binding pocket; other site 218493006639 putative dimerization interface [polypeptide binding]; other site 218493006643 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 218493006644 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 218493006645 putative NAD(P) binding site [chemical binding]; other site 218493006646 putative substrate binding site [chemical binding]; other site 218493006647 catalytic Zn binding site [ion binding]; other site 218493006648 structural Zn binding site [ion binding]; other site 218493006649 dimer interface [polypeptide binding]; other site 218493006655 signal peptide predicted for SBG1229 by SignalP 2.0 HMM (Signal peptide probabilty 0.771) with cleavage site probability 0.343 between residues 22 and 23 218493006656 signal peptide predicted for SBG1230 by SignalP 2.0 HMM (Signal peptide probabilty 0.820) with cleavage site probability 0.693 between residues 19 and 20 218493006657 Uncharacterized conserved protein [Function unknown]; Region: COG1683 218493006658 Uncharacterized conserved protein [Function unknown]; Region: COG3272 218493006659 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 218493006663 transcriptional regulator MirA; Provisional; Region: PRK15043 218493006664 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 218493006665 DNA binding residues [nucleotide binding] 218493006668 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 218493006669 type VI secretion system 218493006670 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 218493006671 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 218493006673 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 218493006674 2 probable transmembrane helices predicted for SBG1234 by TMHMM2.0 at aa 5-27 and 326-348 218493006675 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 218493006676 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 218493006677 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 218493006679 Protein of unknown function (DUF770); Region: DUF770; pfam05591 218493006681 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 218493006682 Protein of unknown function (DUF877); Region: DUF877; pfam05943 218493006684 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 218493006686 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 218493006688 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 218493006689 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 218493006691 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 218493006693 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 218493006694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493006695 Walker A motif; other site 218493006696 ATP binding site [chemical binding]; other site 218493006697 Walker B motif; other site 218493006698 arginine finger; other site 218493006699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493006700 Walker A motif; other site 218493006701 ATP binding site [chemical binding]; other site 218493006702 Walker B motif; other site 218493006709 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218493006710 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218493006711 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218493006712 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 218493006716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 218493006721 multidrug efflux protein; Reviewed; Region: PRK01766 218493006722 signal peptide predicted for SBG1248 by SignalP 2.0 HMM (Signal peptide probabilty 0.865) with cleavage site probability 0.405 between residues 26 and 27 218493006723 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 218493006724 cation binding site [ion binding]; other site 218493006725 12 probable transmembrane helices predicted for SBG1248 by TMHMM2.0 at aa 12-34, 44-66, 91-113,128-147, 160-180, 190-212, 241-263, 278-300, 313-335,350-367, 387-409 and 419-438 218493006728 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 218493006729 Lumazine binding domain; Region: Lum_binding; pfam00677 218493006730 Lumazine binding domain; Region: Lum_binding; pfam00677 218493006733 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 218493006734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 218493006735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493006736 S-adenosylmethionine binding site [chemical binding]; other site 218493006738 putative transporter; Provisional; Region: PRK11043 218493006739 signal peptide predicted for SBG1251 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.907 between residues 30 and 31 218493006740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006741 putative substrate translocation pore; other site 218493006742 12 probable transmembrane helices predicted for SBG1251 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119,131-153, 158-180, 208-230, 235-257, 270-289, 299-321,333-355 and 359-377 218493006745 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 218493006746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493006747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493006748 dimerization interface [polypeptide binding]; other site 218493006752 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 218493006753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493006754 DNA binding site [nucleotide binding] 218493006755 domain linker motif; other site 218493006756 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 218493006757 dimerization interface [polypeptide binding]; other site 218493006758 ligand binding site [chemical binding]; other site 218493006762 superoxide dismutase; Provisional; Region: PRK10543 218493006763 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218493006764 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218493006768 signal peptide predicted for SBG1256 by SignalP 2.0 HMM (Signal peptide probabilty 0.850) with cleavage site probability 0.764 between residues 38 and 39 218493006769 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 218493006770 NlpC/P60 family; Region: NLPC_P60; pfam00877 218493006772 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 218493006773 putative GSH binding site [chemical binding]; other site 218493006774 catalytic residues [active] 218493006777 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 218493006778 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 218493006779 dimer interface [polypeptide binding]; other site 218493006780 catalytic site [active] 218493006781 putative active site [active] 218493006782 putative substrate binding site [chemical binding]; other site 218493006784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218493006785 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 218493006786 dimer interface [polypeptide binding]; other site 218493006787 active site 218493006788 metal binding site [ion binding]; metal-binding site 218493006789 glutathione binding site [chemical binding]; other site 218493006793 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218493006794 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 218493006795 FMN binding site [chemical binding]; other site 218493006796 active site 218493006797 substrate binding site [chemical binding]; other site 218493006798 catalytic residue [active] 218493006801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218493006802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493006805 Predicted Fe-S protein [General function prediction only]; Region: COG3313 218493006807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493006808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493006809 active site 218493006810 catalytic tetrad [active] 218493006812 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 218493006813 signal peptide predicted for SBG1264 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.968 between residues 19 and 20 218493006814 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 218493006815 E-class dimer interface [polypeptide binding]; other site 218493006816 P-class dimer interface [polypeptide binding]; other site 218493006817 active site 218493006818 Cu2+ binding site [ion binding]; other site 218493006819 Zn2+ binding site [ion binding]; other site 218493006823 Fusaric acid resistance protein family; Region: FUSC; pfam04632 218493006824 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218493006825 12 probable transmembrane helices predicted for SBG1265 by TMHMM2.0 at aa 23-41, 46-65, 72-90, 94-113,120-142, 157-179, 362-381, 386-404, 411-433, 438-455,462-484 and 494-511 218493006829 signal peptide predicted for SBG1266 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.838 between residues 24 and 25 218493006830 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 218493006831 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493006832 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493006834 1 probable transmembrane helix predicted for SBG1266 by TMHMM2.0 at aa 12-29 218493006835 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 218493006836 2 probable transmembrane helices predicted for SBG1267 by TMHMM2.0 at aa 21-40 and 55-77 218493006838 transcriptional regulator SlyA; Provisional; Region: PRK03573 218493006839 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 218493006842 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 218493006843 signal peptide predicted for SBG1269 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.769 between residues 21 and 22 218493006846 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 218493006848 lysozyme inhibitor; Provisional; Region: PRK11372 218493006849 signal peptide predicted for SBG1271 by SignalP 2.0 HMM (Signal peptide probabilty 0.795) with cleavage site probability 0.673 between residues 22 and 23 218493006850 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 218493006852 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 218493006853 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 218493006854 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 218493006856 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 218493006857 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 218493006858 active site 218493006859 HIGH motif; other site 218493006860 dimer interface [polypeptide binding]; other site 218493006861 KMSKS motif; other site 218493006862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493006863 RNA binding surface [nucleotide binding]; other site 218493006867 pyridoxamine kinase; Validated; Region: PRK05756 218493006868 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 218493006869 dimer interface [polypeptide binding]; other site 218493006870 pyridoxal binding site [chemical binding]; other site 218493006871 ATP binding site [chemical binding]; other site 218493006873 glutathionine S-transferase; Provisional; Region: PRK10542 218493006874 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 218493006875 C-terminal domain interface [polypeptide binding]; other site 218493006876 GSH binding site (G-site) [chemical binding]; other site 218493006877 dimer interface [polypeptide binding]; other site 218493006878 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 218493006879 dimer interface [polypeptide binding]; other site 218493006880 N-terminal domain interface [polypeptide binding]; other site 218493006881 substrate binding pocket (H-site) [chemical binding]; other site 218493006884 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 218493006885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493006886 putative substrate translocation pore; other site 218493006887 POT family; Region: PTR2; pfam00854 218493006888 14 probable transmembrane helices predicted for SBG1276 by TMHMM2.0 at aa 22-44, 59-81, 90-107,112-129, 150-172, 177-199, 220-239, 244-261, 274-296,323-340, 353-370, 385-407, 419-441 and 456-478 218493006893 endonuclease III; Provisional; Region: PRK10702 218493006894 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218493006895 minor groove reading motif; other site 218493006896 helix-hairpin-helix signature motif; other site 218493006897 substrate binding pocket [chemical binding]; other site 218493006898 active site 218493006899 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 218493006904 electron transport complex RsxE subunit; Provisional; Region: PRK12405 218493006905 signal peptide predicted for SBG1278 by SignalP 2.0 HMM (Signal peptide probabilty 0.932) with cleavage site probability 0.443 between residues 38 and 39 218493006906 6 probable transmembrane helices predicted for SBG1278 by TMHMM2.0 at aa 12-31, 35-57, 69-87, 91-113,126-148 and 183-205 218493006908 signal peptide predicted for SBG1279 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.934 between residues 24 and 25 218493006909 electron transport complex protein RnfG; Validated; Region: PRK01908 218493006911 signal peptide predicted for SBG1280 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.497 between residues 50 and 51 218493006912 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 218493006914 10 probable transmembrane helices predicted for SBG1280 by TMHMM2.0 at aa 20-39, 43-65, 78-109,124-146, 158-180, 214-236, 243-262, 272-294, 301-318 and 323-342 218493006915 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 218493006916 SLBB domain; Region: SLBB; pfam10531 218493006917 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493006923 electron transport complex protein RnfB; Provisional; Region: PRK05113 218493006924 signal peptide predicted for SBG1282 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.870 between residues 30 and 31 218493006925 Putative Fe-S cluster; Region: FeS; cl17515 218493006926 4Fe-4S binding domain; Region: Fer4; pfam00037 218493006932 1 probable transmembrane helix predicted for SBG1282 by TMHMM2.0 at aa 4-26 218493006933 electron transport complex protein RsxA; Provisional; Region: PRK05151 218493006935 6 probable transmembrane helices predicted for SBG1283 by TMHMM2.0 at aa 5-27, 42-64, 69-88, 103-125,132-154 and 169-191 218493006936 signal peptide predicted for SBG1284 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.623 between residues 39 and 40 218493006937 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 218493006938 4 probable transmembrane helices predicted for SBG1284 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133 218493006939 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 218493006941 1 probable transmembrane helix predicted for SBG1286 by TMHMM2.0 at aa 12-34 218493006942 putative oxidoreductase; Provisional; Region: PRK11579 218493006943 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218493006944 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218493006947 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 218493006948 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 218493006949 active site 218493006950 purine riboside binding site [chemical binding]; other site 218493006953 signal peptide predicted for SBG1289 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 41 and 42 218493006954 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 218493006955 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006956 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006957 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006958 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 218493006959 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 218493006960 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006961 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006962 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 218493006971 1 probable transmembrane helix predicted for SBG1289 by TMHMM2.0 at aa 20-42 218493006972 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 218493006973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493006975 homodimer interface [polypeptide binding]; other site 218493006976 catalytic residue [active] 218493006978 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 218493006979 signal peptide predicted for SBG1291 by SignalP 2.0 HMM (Signal peptide probabilty 0.855) with cleavage site probability 0.537 between residues 44 and 45 218493006980 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 218493006981 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493006982 active site turn [active] 218493006983 phosphorylation site [posttranslational modification] 218493006986 10 probable transmembrane helices predicted for SBG1291 by TMHMM2.0 at aa 21-43, 72-89, 96-118,138-160, 173-195, 200-222, 296-313, 323-345, 352-374 and 397-419 218493006988 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 218493006989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493006990 DNA binding site [nucleotide binding] 218493006991 domain linker motif; other site 218493006992 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 218493006993 putative dimerization interface [polypeptide binding]; other site 218493006994 putative ligand binding site [chemical binding]; other site 218493006998 signal peptide predicted for SBG1293 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.855 between residues 19 and 20 218493006999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 218493007000 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 218493007003 1 probable transmembrane helix predicted for SBG1293 by TMHMM2.0 at aa 5-24 218493007004 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 218493007005 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 218493007006 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 218493007010 fumarate hydratase; Provisional; Region: PRK15389 218493007011 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 218493007012 Fumarase C-terminus; Region: Fumerase_C; pfam05683 218493007017 fumarate hydratase; Reviewed; Region: fumC; PRK00485 218493007018 Class II fumarases; Region: Fumarase_classII; cd01362 218493007019 active site 218493007020 tetramer interface [polypeptide binding]; other site 218493007023 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 218493007025 signal peptide predicted for SBG1298 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.475 between residues 29 and 30 218493007026 sensor protein RstB; Provisional; Region: PRK10604 218493007027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493007028 dimerization interface [polypeptide binding]; other site 218493007029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493007030 dimer interface [polypeptide binding]; other site 218493007031 phosphorylation site [posttranslational modification] 218493007032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493007033 ATP binding site [chemical binding]; other site 218493007034 Mg2+ binding site [ion binding]; other site 218493007035 G-X-G motif; other site 218493007040 2 probable transmembrane helices predicted for SBG1298 by TMHMM2.0 at aa 5-27 and 140-157 218493007041 signal peptide predicted for SBG1299 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.858 between residues 26 and 27 218493007042 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 218493007043 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 218493007044 active site 218493007046 signal peptide predicted for SBG1300 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22 218493007047 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493007048 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493007049 trimer interface [polypeptide binding]; other site 218493007050 eyelet of channel; other site 218493007054 1 probable transmembrane helix predicted for SBG1300 by TMHMM2.0 at aa 5-22 218493007055 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 218493007056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493007057 active site 218493007058 phosphorylation site [posttranslational modification] 218493007059 intermolecular recognition site; other site 218493007060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493007061 DNA binding site [nucleotide binding] 218493007064 GlpM protein; Region: GlpM; pfam06942 218493007065 4 probable transmembrane helices predicted for SBG1302 by TMHMM2.0 at aa 4-21, 28-47, 57-79 and 86-108 218493007067 signal peptide predicted for SBG1303 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.390 between residues 34 and 35 218493007068 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 218493007069 Spore germination protein; Region: Spore_permease; cl17796 218493007070 13 probable transmembrane helices predicted for SBG1303 by TMHMM2.0 at aa 5-27, 37-59, 90-112,127-149, 156-178, 203-222, 235-257, 277-299, 332-351,356-378, 385-403, 407-426 and 442-459 218493007072 signal peptide predicted for SBG1304 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493007073 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493007074 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493007075 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493007077 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 218493007078 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 218493007079 ligand binding site [chemical binding]; other site 218493007080 homodimer interface [polypeptide binding]; other site 218493007081 NAD(P) binding site [chemical binding]; other site 218493007082 trimer interface B [polypeptide binding]; other site 218493007083 trimer interface A [polypeptide binding]; other site 218493007084 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 218493007088 5 probable transmembrane helices predicted for SBG1305 by TMHMM2.0 at aa 169-191, 402-419, 423-445,452-471 and 476-498 218493007091 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 218493007092 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 218493007094 9 probable transmembrane helices predicted for SBG1306 by TMHMM2.0 at aa 5-24, 33-50, 55-72, 85-107,122-144, 164-181, 185-207, 214-236 and 240-259 218493007095 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 218493007096 signal peptide predicted for SBG1307 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.999 between residues 30 and 31 218493007097 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218493007099 8 probable transmembrane helices predicted for SBG1307 by TMHMM2.0 at aa 5-24, 29-51, 63-85, 144-166,196-218, 222-244, 257-279 and 299-321 218493007100 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 218493007101 signal peptide predicted for SBG1309 by SignalP 2.0 HMM (Signal peptide probabilty 0.818) with cleavage site probability 0.139 between residues 24 and 25 218493007102 4 probable transmembrane helices predicted for SBG1309 by TMHMM2.0 at aa 2-19, 29-51, 56-78 and 82-101 218493007104 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 218493007105 signal peptide predicted for SBG1310 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.536 between residues 21 and 22 218493007106 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 218493007110 signal peptide predicted for SBG1311 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 30 and 31 218493007111 1 probable transmembrane helix predicted for SBG1311 by TMHMM2.0 at aa 13-35 218493007112 signal peptide predicted for SBG1312 by SignalP 2.0 HMM (Signal peptide probabilty 0.636) with cleavage site probability 0.586 between residues 27 and 28 218493007113 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218493007114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007115 putative substrate translocation pore; other site 218493007116 12 probable transmembrane helices predicted for SBG1313 by TMHMM2.0 at aa 37-59, 74-95, 102-124,128-150, 157-179, 189-211, 240-262, 272-291, 304-323,328-350, 363-385 and 389-411 218493007120 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 218493007121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493007122 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 218493007123 dimerization interface [polypeptide binding]; other site 218493007124 substrate binding pocket [chemical binding]; other site 218493007128 1 probable transmembrane helix predicted for SBG1314 by TMHMM2.0 at aa 227-249 218493007129 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218493007130 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493007132 putative dithiobiotin synthetase; Provisional; Region: PRK12374 218493007133 AAA domain; Region: AAA_26; pfam13500 218493007136 signal peptide predicted for SBG1317 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.793 between residues 37 and 38 218493007137 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 218493007138 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 218493007139 Cl- selectivity filter; other site 218493007140 Cl- binding residues [ion binding]; other site 218493007141 pore gating glutamate residue; other site 218493007142 dimer interface [polypeptide binding]; other site 218493007144 10 probable transmembrane helices predicted for SBG1317 by TMHMM2.0 at aa 12-34, 66-83, 158-180,190-212, 233-255, 270-292, 301-323, 333-355, 362-384 and 394-416 218493007147 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 218493007148 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 218493007149 Walker A/P-loop; other site 218493007150 ATP binding site [chemical binding]; other site 218493007151 Q-loop/lid; other site 218493007152 ABC transporter signature motif; other site 218493007153 Walker B; other site 218493007154 D-loop; other site 218493007155 H-loop/switch region; other site 218493007156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 218493007161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493007162 dimer interface [polypeptide binding]; other site 218493007163 conserved gate region; other site 218493007164 ABC-ATPase subunit interface; other site 218493007166 5 probable transmembrane helices predicted for SBG1319 by TMHMM2.0 at aa 22-44, 51-73, 78-100, 149-171 and 181-203 218493007168 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 218493007169 signal peptide predicted for SBG1320 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 23 and 24 218493007171 1 probable transmembrane helix predicted for SBG1320 by TMHMM2.0 at aa 7-29 218493007172 signal peptide predicted for SBG1321 by SignalP 2.0 HMM (Signal peptide probabilty 0.799) with cleavage site probability 0.565 between residues 26 and 27 218493007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493007174 dimer interface [polypeptide binding]; other site 218493007175 conserved gate region; other site 218493007176 putative PBP binding loops; other site 218493007177 ABC-ATPase subunit interface; other site 218493007179 5 probable transmembrane helices predicted for SBG1321 by TMHMM2.0 at aa 10-29, 46-68, 94-116, 173-195 and 205-227 218493007181 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 218493007183 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 218493007185 8 probable transmembrane helices predicted for SBG1323 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-133,148-170, 182-204, 224-244 and 251-273 218493007186 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 218493007187 4Fe-4S binding domain; Region: Fer4; pfam00037 218493007193 signal peptide predicted for SBG1325 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.668 between residues 45 and 46 218493007194 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 218493007195 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 218493007196 putative [Fe4-S4] binding site [ion binding]; other site 218493007197 putative molybdopterin cofactor binding site [chemical binding]; other site 218493007198 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 218493007199 putative molybdopterin cofactor binding site; other site 218493007204 signal peptide predicted for SBG1326 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.975 between residues 42 and 43 218493007205 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 218493007206 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 218493007207 putative [Fe4-S4] binding site [ion binding]; other site 218493007208 putative molybdopterin cofactor binding site [chemical binding]; other site 218493007209 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 218493007210 putative molybdopterin cofactor binding site; other site 218493007216 1 probable transmembrane helix predicted for SBG1326 by TMHMM2.0 at aa 20-42 218493007217 signal peptide predicted for SBG1327 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 22 and 23 218493007218 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 218493007220 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 218493007221 signal peptide predicted for SBG1328 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.711 between residues 16 and 17 218493007224 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 218493007225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493007226 Coenzyme A binding pocket [chemical binding]; other site 218493007227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 218493007229 signal peptide predicted for SBG1330 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 28 and 29 218493007230 hypothetical protein; Provisional; Region: PRK13659 218493007232 hypothetical protein; Provisional; Region: PRK02237 218493007234 4 probable transmembrane helices predicted for SBG1331 by TMHMM2.0 at aa 7-26, 30-52, 59-78 and 88-106 218493007235 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 218493007236 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 218493007237 putative active site pocket [active] 218493007238 putative metal binding site [ion binding]; other site 218493007243 putative oxidoreductase; Provisional; Region: PRK10083 218493007244 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 218493007245 putative NAD(P) binding site [chemical binding]; other site 218493007246 catalytic Zn binding site [ion binding]; other site 218493007247 structural Zn binding site [ion binding]; other site 218493007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007252 metabolite-proton symporter; Region: 2A0106; TIGR00883 218493007253 putative substrate translocation pore; other site 218493007254 10 probable transmembrane helices predicted for SBG1334 by TMHMM2.0 at aa 20-42, 55-77, 89-111,159-181, 188-210, 286-305, 312-331, 341-363, 384-401 and 406-428 218493007256 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 218493007257 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218493007258 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218493007263 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 218493007265 Transcriptional regulators [Transcription]; Region: GntR; COG1802 218493007266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493007267 DNA-binding site [nucleotide binding]; DNA binding site 218493007268 FCD domain; Region: FCD; pfam07729 218493007272 malonic semialdehyde reductase; Provisional; Region: PRK10538 218493007273 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 218493007274 putative NAD(P) binding site [chemical binding]; other site 218493007275 homodimer interface [polypeptide binding]; other site 218493007276 homotetramer interface [polypeptide binding]; other site 218493007277 active site 218493007280 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 218493007281 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 218493007282 active site 218493007283 Zn binding site [ion binding]; other site 218493007286 hypothetical protein; Validated; Region: PRK03657 218493007288 hypothetical protein; Provisional; Region: PRK10053 218493007289 signal peptide predicted for SBG1341 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 19 and 20 218493007291 putative transporter; Provisional; Region: PRK10054 218493007292 signal peptide predicted for SBG1342 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.649 between residues 24 and 25 218493007293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007294 putative substrate translocation pore; other site 218493007295 12 probable transmembrane helices predicted for SBG1342 by TMHMM2.0 at aa 12-34, 44-66, 75-94, 99-121,133-155, 165-187, 208-230, 245-264, 271-293, 298-320,333-355 and 359-381 218493007299 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 218493007300 EamA-like transporter family; Region: EamA; pfam00892 218493007301 EamA-like transporter family; Region: EamA; pfam00892 218493007302 10 probable transmembrane helices predicted for SBG1343 by TMHMM2.0 at aa 7-29, 33-51, 58-80, 90-109,116-135, 139-161, 173-195, 215-237, 244-263 and 267-289 218493007305 signal peptide predicted for SBG1344 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.994 between residues 21 and 22 218493007306 MarB protein; Region: MarB; pfam13999 218493007307 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 218493007308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493007309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493007313 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 218493007314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218493007317 inner membrane protein; Provisional; Region: PRK10995 218493007318 signal peptide predicted for SBG1347 by SignalP 2.0 HMM (Signal peptide probabilty 0.701) with cleavage site probability 0.268 between residues 19 and 20 218493007320 6 probable transmembrane helices predicted for SBG1347 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 117-139,154-176 and 196-217 218493007321 putative arabinose transporter; Provisional; Region: PRK03545 218493007322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007323 putative substrate translocation pore; other site 218493007324 12 probable transmembrane helices predicted for SBG1348 by TMHMM2.0 at aa 12-34, 49-71, 80-99,109-131, 138-160, 170-189, 210-229, 244-266, 273-295,299-321, 333-352 and 362-384 218493007326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493007327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493007328 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 218493007329 putative dimerization interface [polypeptide binding]; other site 218493007333 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 218493007334 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 218493007335 NAD(P) binding site [chemical binding]; other site 218493007336 catalytic residues [active] 218493007339 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 218493007340 glutaminase; Provisional; Region: PRK00971 218493007342 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 218493007343 altronate oxidoreductase; Provisional; Region: PRK03643 218493007344 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218493007345 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218493007348 Predicted membrane protein [Function unknown]; Region: COG3781 218493007349 4 probable transmembrane helices predicted for SBG1354 by TMHMM2.0 at aa 40-62, 83-105, 111-129 and 277-299 218493007351 signal peptide predicted for SBG1355 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25 218493007352 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 218493007353 signal peptide predicted for SBG1356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 22 and 23 218493007354 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493007355 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493007356 trimer interface [polypeptide binding]; other site 218493007357 eyelet of channel; other site 218493007358 1 probable transmembrane helix predicted for SBG1356 by TMHMM2.0 at aa 5-27 218493007361 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 218493007362 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 218493007364 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 218493007365 hya operon 218493007366 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 218493007367 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 218493007368 Rubredoxin [Energy production and conversion]; Region: COG1773 218493007369 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 218493007370 iron binding site [ion binding]; other site 218493007373 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 218493007375 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 218493007376 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 218493007377 putative substrate-binding site; other site 218493007378 nickel binding site [ion binding]; other site 218493007380 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 218493007382 4 probable transmembrane helices predicted for SBG1362 by TMHMM2.0 at aa 38-57, 77-99, 146-168 and 198-220 218493007384 hydrogenase 1 large subunit; Provisional; Region: PRK10170 218493007385 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 218493007389 signal peptide predicted for SBG1364 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.979 between residues 45 and 46 218493007390 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 218493007391 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 218493007394 1 probable transmembrane helix predicted for SBG1364 by TMHMM2.0 at aa 21-43 218493007395 signal peptide predicted for SBG1365 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.935 between residues 23 and 24 218493007396 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 218493007397 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 218493007398 active site 218493007401 Transcriptional regulators [Transcription]; Region: FadR; COG2186 218493007402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493007403 DNA-binding site [nucleotide binding]; DNA binding site 218493007404 FCD domain; Region: FCD; pfam07729 218493007408 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493007409 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 218493007410 putative NAD(P) binding site [chemical binding]; other site 218493007411 catalytic Zn binding site [ion binding]; other site 218493007412 structural Zn binding site [ion binding]; other site 218493007415 signal peptide predicted for SBG1368 by SignalP 2.0 HMM (Signal peptide probabilty 0.868) with cleavage site probability 0.539 between residues 29 and 30 218493007416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007417 D-galactonate transporter; Region: 2A0114; TIGR00893 218493007418 putative substrate translocation pore; other site 218493007419 12 probable transmembrane helices predicted for SBG1368 by TMHMM2.0 at aa 7-26, 46-68, 75-97, 101-123,135-157, 162-184, 228-250, 265-287, 303-325, 329-350,362-384 and 394-413 218493007421 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 218493007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493007424 putative substrate translocation pore; other site 218493007425 12 probable transmembrane helices predicted for SBG1370 by TMHMM2.0 at aa 25-47, 57-79, 86-105,110-132, 144-166, 171-193, 214-236, 261-283, 292-311,316-338, 351-373 and 378-400 218493007429 hypothetical protein; Provisional; Region: PRK06184 218493007430 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 218493007432 Transcriptional regulators [Transcription]; Region: MarR; COG1846 218493007433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493007434 putative DNA binding site [nucleotide binding]; other site 218493007435 putative Zn2+ binding site [ion binding]; other site 218493007437 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 218493007438 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 218493007440 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 218493007441 homotrimer interaction site [polypeptide binding]; other site 218493007442 putative active site [active] 218493007444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 218493007446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 218493007448 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 218493007449 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 218493007450 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 218493007451 active site 218493007452 catalytic site [active] 218493007456 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 218493007457 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 218493007458 active site 218493007459 catalytic site [active] 218493007461 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 218493007462 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 218493007463 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 218493007464 catalytic site [active] 218493007465 active site 218493007466 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 218493007469 signal peptide predicted for SBG1380 by SignalP 2.0 HMM (Signal peptide probabilty 0.917) with cleavage site probability 0.470 between residues 21 and 22 218493007470 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 218493007473 signal peptide predicted for SBG1381 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 24 and 25 218493007474 acid-resistance protein; Provisional; Region: hdeB; PRK11566 218493007475 1 probable transmembrane helix predicted for SBG1381 by TMHMM2.0 at aa 4-26 218493007476 multidrug efflux protein; Reviewed; Region: PRK09579 218493007477 signal peptide predicted for SBG1382 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.632 between residues 30 and 31 218493007479 12 probable transmembrane helices predicted for SBG1382 by TMHMM2.0 at aa 7-29, 333-355, 360-382,387-409, 430-452, 467-489, 521-543, 844-866, 873-895,899-918, 944-966 and 981-1003 218493007480 signal peptide predicted for SBG1383 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.361 between residues 29 and 30 218493007481 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 218493007482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493007483 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493007485 1 probable transmembrane helix predicted for SBG1383 by TMHMM2.0 at aa 5-24 218493007486 Predicted membrane protein [Function unknown]; Region: COG2259 218493007487 4 probable transmembrane helices predicted for SBG1384 by TMHMM2.0 at aa 49-71, 86-108, 113-135 and 145-167 218493007489 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 218493007491 malate dehydrogenase; Provisional; Region: PRK13529 218493007492 Malic enzyme, N-terminal domain; Region: malic; pfam00390 218493007493 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 218493007494 NAD(P) binding site [chemical binding]; other site 218493007500 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 218493007501 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 218493007502 NAD binding site [chemical binding]; other site 218493007503 substrate binding site [chemical binding]; other site 218493007504 catalytic Zn binding site [ion binding]; other site 218493007505 tetramer interface [polypeptide binding]; other site 218493007506 structural Zn binding site [ion binding]; other site 218493007511 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 218493007512 signal peptide predicted for SBG1388 by SignalP 2.0 HMM (Signal peptide probabilty 0.863) with cleavage site probability 0.398 between residues 41 and 42 218493007513 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 218493007514 4 probable transmembrane helices predicted for SBG1388 by TMHMM2.0 at aa 21-40, 55-77, 117-139 and 154-176 218493007515 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 218493007516 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 218493007518 1 probable transmembrane helix predicted for SBG1389 by TMHMM2.0 at aa 260-279 218493007521 contains a UGA stop codon which is readthrough as an opal codon by the selenocysteine tRNA 218493007525 TGA stop codon which is read-through as an opal codon by the selenocysteine tRNA 218493007528 signal peptide predicted for SBG1391 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.520 between residues 33 and 34 218493007529 aromatic amino acid exporter; Provisional; Region: PRK11689 218493007530 10 probable transmembrane helices predicted for SBG1392 by TMHMM2.0 at aa 7-24, 34-53, 65-87, 91-113,120-139, 152-174, 181-203, 213-235, 242-264 and 270-289 218493007532 signal peptide predicted for SBG1393 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 34 and 35 218493007533 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493007534 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493007535 trimer interface [polypeptide binding]; other site 218493007536 eyelet of channel; other site 218493007537 1 probable transmembrane helix predicted for SBG1393 by TMHMM2.0 at aa 16-38 218493007540 Uncharacterized conserved protein [Function unknown]; Region: COG3791 218493007542 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 218493007543 signal peptide predicted for SBG1395 by SignalP 2.0 HMM (Signal peptide probabilty 0.622) with cleavage site probability 0.485 between residues 27 and 28 218493007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493007545 putative substrate translocation pore; other site 218493007546 14 probable transmembrane helices predicted for SBG1395 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119,132-154, 158-180, 193-212, 222-240, 260-282, 297-319,322-344, 354-376, 389-411 and 468-490 218493007548 TetR family transcriptional regulator; Provisional; Region: PRK14996 218493007549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493007551 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 218493007552 signal peptide predicted for SBG1397 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.930 between residues 57 and 58 218493007553 12 probable transmembrane helices predicted for SBG1397 by TMHMM2.0 at aa 36-58, 73-95, 102-121,131-153, 174-196, 211-233, 254-276, 286-308, 313-335,345-367, 401-418 and 433-455 218493007555 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 218493007556 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 218493007557 [4Fe-4S] binding site [ion binding]; other site 218493007558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493007559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493007560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493007561 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 218493007562 molybdopterin cofactor binding site; other site 218493007568 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 218493007570 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 218493007572 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 218493007574 5 probable transmembrane helices predicted for SBG1401 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 128-150 and 185-207 218493007575 hypothetical protein; Provisional; Region: PRK10281 218493007577 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 218493007579 transcriptional activator RhaS; Provisional; Region: PRK13503 218493007580 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218493007581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493007585 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 218493007587 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218493007588 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 218493007589 11 probable transmembrane helices predicted for SBG1406 by TMHMM2.0 at aa 13-35, 48-70, 83-100,110-132, 153-175, 180-202, 230-252, 267-289, 296-313,372-394 and 401-423 218493007591 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 218493007592 signal peptide predicted for SBG1407 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 22 and 23 218493007593 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 218493007594 trimer interface; other site 218493007595 sugar binding site [chemical binding]; other site 218493007597 L-asparagine permease; Provisional; Region: PRK15049 218493007599 12 probable transmembrane helices predicted for SBG1409 by TMHMM2.0 at aa 37-59, 64-86, 107-129,144-166, 173-195, 218-240, 260-282, 302-324, 351-373,377-399, 420-442 and 446-468 218493007601 signal peptide predicted for SBG1410 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.225 between residues 19 and 20 218493007602 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493007604 1 probable transmembrane helix predicted for SBG1410 by TMHMM2.0 at aa 4-26 218493007606 signal peptide predicted for SBG1411 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 30 and 31 218493007607 Uncharacterized conserved protein [Function unknown]; Region: COG3391 218493007609 signal peptide predicted for SBG1412 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 26 and 27 218493007610 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 218493007611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493007612 N-terminal plug; other site 218493007613 ligand-binding site [chemical binding]; other site 218493007616 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 218493007617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493007618 DNA-binding site [nucleotide binding]; DNA binding site 218493007619 FCD domain; Region: FCD; pfam07729 218493007622 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 218493007623 Prostaglandin dehydrogenases; Region: PGDH; cd05288 218493007624 NAD(P) binding site [chemical binding]; other site 218493007625 substrate binding site [chemical binding]; other site 218493007626 dimer interface [polypeptide binding]; other site 218493007628 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 218493007629 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 218493007631 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 218493007632 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 218493007634 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 218493007635 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 218493007636 2 probable transmembrane helices predicted for SBG1420 by TMHMM2.0 at aa 27-44 and 54-76 218493007637 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 218493007638 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 218493007639 tetrameric interface [polypeptide binding]; other site 218493007640 NAD binding site [chemical binding]; other site 218493007641 catalytic residues [active] 218493007642 substrate binding site [chemical binding]; other site 218493007645 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218493007646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493007647 DNA-binding site [nucleotide binding]; DNA binding site 218493007648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493007649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493007650 homodimer interface [polypeptide binding]; other site 218493007651 catalytic residue [active] 218493007654 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 218493007655 signal peptide predicted for SBG1423 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.997 between residues 20 and 21 218493007657 2 probable transmembrane helices predicted for SBG1424 by TMHMM2.0 at aa 37-59 and 91-113 218493007660 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 218493007662 9 probable transmembrane helices predicted for SBG1428 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148,186-208, 215-237, 323-345, 358-380 and 408-430 218493007663 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 218493007664 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218493007665 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218493007667 8 probable transmembrane helices predicted for SBG1429 by TMHMM2.0 at aa 5-23, 78-100, 121-143, 158-180,199-221, 231-248, 261-283 and 303-325 218493007669 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 218493007670 signal peptide predicted for SBG1430 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493007671 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218493007672 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 218493007673 Peptidase family U32; Region: Peptidase_U32; pfam01136 218493007674 Collagenase; Region: DUF3656; pfam12392 218493007677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218493007678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493007679 non-specific DNA binding site [nucleotide binding]; other site 218493007680 salt bridge; other site 218493007681 sequence-specific DNA binding site [nucleotide binding]; other site 218493007682 Cupin domain; Region: Cupin_2; pfam07883 218493007685 signal peptide predicted for SBG1433 by SignalP 2.0 HMM (Signal peptide probabilty 0.738) with cleavage site probability 0.221 between residues 51 and 52 218493007686 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 218493007687 benzoate transporter; Region: benE; TIGR00843 218493007689 12 probable transmembrane helices predicted for SBG1433 by TMHMM2.0 at aa 21-43, 53-75, 80-99,104-123, 130-149, 153-172, 179-196, 211-233, 254-285,300-322, 329-351 and 371-393 218493007691 signal peptide predicted for SBG1434 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.679 between residues 24 and 25 218493007692 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 218493007694 tellurite resistance protein TehB; Provisional; Region: PRK11207 218493007695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493007696 S-adenosylmethionine binding site [chemical binding]; other site 218493007698 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 218493007699 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 218493007700 gating phenylalanine in ion channel; other site 218493007701 10 probable transmembrane helices predicted for SBG1436 by TMHMM2.0 at aa 13-32, 47-69, 82-104,108-130, 143-165, 169-188, 200-222, 237-254, 261-280 and 290-312 218493007705 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 218493007706 putative trimer interface [polypeptide binding]; other site 218493007707 putative CoA binding site [chemical binding]; other site 218493007708 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 218493007709 putative trimer interface [polypeptide binding]; other site 218493007710 putative CoA binding site [chemical binding]; other site 218493007717 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218493007718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493007719 Coenzyme A binding pocket [chemical binding]; other site 218493007722 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 218493007723 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 218493007724 oligomer interface [polypeptide binding]; other site 218493007725 active site 218493007726 metal binding site [ion binding]; metal-binding site 218493007728 signal peptide predicted for SBG1440 by SignalP 2.0 HMM (Signal peptide probabilty 0.882) with cleavage site probability 0.402 between residues 22 and 23 218493007729 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 218493007730 active site 218493007731 P-loop; other site 218493007732 phosphorylation site [posttranslational modification] 218493007734 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 218493007735 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 218493007736 9 probable transmembrane helices predicted for SBG1441 by TMHMM2.0 at aa 5-27, 32-54, 82-104, 125-147,216-235, 242-264, 298-320, 349-371 and 408-430 218493007738 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 218493007740 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493007741 active site 218493007742 phosphorylation site [posttranslational modification] 218493007744 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 218493007745 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218493007746 substrate binding site [chemical binding]; other site 218493007747 hexamer interface [polypeptide binding]; other site 218493007748 metal binding site [ion binding]; metal-binding site 218493007752 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493007753 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218493007754 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493007758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218493007759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493007760 Coenzyme A binding pocket [chemical binding]; other site 218493007762 signal peptide predicted for SBG1447 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25 218493007763 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 218493007764 teramer interface [polypeptide binding]; other site 218493007765 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 218493007766 active site 218493007767 FMN binding site [chemical binding]; other site 218493007768 catalytic residues [active] 218493007771 signal peptide predicted for SBG1448 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 23 and 24 218493007772 Uncharacterized conserved protein [Function unknown]; Region: COG2353 218493007774 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 218493007775 signal peptide predicted for SBG1449 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493007776 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 218493007779 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 218493007780 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 218493007781 substrate binding pocket [chemical binding]; other site 218493007782 catalytic triad [active] 218493007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 218493007787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 218493007791 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 218493007792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493007793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493007794 dimerization interface [polypeptide binding]; other site 218493007798 signal peptide predicted for SBG1454 by SignalP 2.0 HMM (Signal peptide probabilty 0.865) with cleavage site probability 0.279 between residues 39 and 40 218493007799 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218493007800 dimer interface [polypeptide binding]; other site 218493007801 ligand binding site [chemical binding]; other site 218493007802 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218493007803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493007804 dimerization interface [polypeptide binding]; other site 218493007805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493007806 dimer interface [polypeptide binding]; other site 218493007807 putative CheW interface [polypeptide binding]; other site 218493007811 2 probable transmembrane helices predicted for SBG1454 by TMHMM2.0 at aa 26-48 and 203-225 218493007813 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 218493007814 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 218493007815 substrate binding site [chemical binding]; other site 218493007816 catalytic Zn binding site [ion binding]; other site 218493007817 NAD binding site [chemical binding]; other site 218493007818 structural Zn binding site [ion binding]; other site 218493007819 dimer interface [polypeptide binding]; other site 218493007823 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 218493007824 putative metal binding site [ion binding]; other site 218493007825 putative homodimer interface [polypeptide binding]; other site 218493007826 putative homotetramer interface [polypeptide binding]; other site 218493007827 putative homodimer-homodimer interface [polypeptide binding]; other site 218493007828 putative allosteric switch controlling residues; other site 218493007831 1 probable transmembrane helix predicted for SBG1458 by TMHMM2.0 at aa 41-60 218493007832 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 218493007834 hypothetical protein; Provisional; Region: PRK09951 218493007836 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 218493007837 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 218493007838 active site 218493007839 DNA binding site [nucleotide binding] 218493007840 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 218493007842 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 218493007843 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 218493007844 Catalytic site [active] 218493007846 signal peptide predicted for SBG1464 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.652 between residues 36 and 37 218493007847 Predicted membrane protein [Function unknown]; Region: COG3326 218493007848 3 probable transmembrane helices predicted for SBG1464 by TMHMM2.0 at aa 7-24, 29-46 and 93-115 218493007851 5 probable transmembrane helices predicted for SBG1465 by TMHMM2.0 at aa 12-34, 54-76, 88-110, 114-136 and 155-177 218493007852 signal peptide predicted for SBG1467 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493007853 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218493007854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493007855 substrate binding pocket [chemical binding]; other site 218493007856 membrane-bound complex binding site; other site 218493007859 signal peptide predicted for SBG1468 by SignalP 2.0 HMM (Signal peptide probabilty 0.684) with cleavage site probability 0.538 between residues 39 and 40 218493007860 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493007861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493007862 dimer interface [polypeptide binding]; other site 218493007863 conserved gate region; other site 218493007864 putative PBP binding loops; other site 218493007865 ABC-ATPase subunit interface; other site 218493007867 3 probable transmembrane helices predicted for SBG1468 by TMHMM2.0 at aa 20-42, 55-77 and 186-208 218493007868 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218493007869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493007870 Walker A/P-loop; other site 218493007871 ATP binding site [chemical binding]; other site 218493007872 Q-loop/lid; other site 218493007873 ABC transporter signature motif; other site 218493007874 Walker B; other site 218493007875 D-loop; other site 218493007876 H-loop/switch region; other site 218493007880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493007881 dimer interface [polypeptide binding]; other site 218493007882 conserved gate region; other site 218493007883 putative PBP binding loops; other site 218493007884 ABC-ATPase subunit interface; other site 218493007886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493007887 S-adenosylmethionine binding site [chemical binding]; other site 218493007889 cytochrome b561; Provisional; Region: PRK11513 218493007891 3 probable transmembrane helices predicted for SBG1471 by TMHMM2.0 at aa 15-37, 58-80 and 114-136 218493007892 Uncharacterized conserved protein [Function unknown]; Region: COG1434 218493007893 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218493007894 putative active site [active] 218493007896 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 218493007897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493007898 ATP binding site [chemical binding]; other site 218493007899 putative Mg++ binding site [ion binding]; other site 218493007900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493007901 nucleotide binding region [chemical binding]; other site 218493007902 ATP-binding site [chemical binding]; other site 218493007903 Helicase associated domain (HA2); Region: HA2; pfam04408 218493007904 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 218493007905 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 218493007910 azoreductase; Reviewed; Region: PRK00170 218493007911 signal peptide predicted for SBG1474 by SignalP 2.0 HMM (Signal peptide probabilty 0.668) with cleavage site probability 0.659 between residues 18 and 19 218493007912 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218493007914 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 218493007915 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493007916 active site 218493007917 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 218493007918 active site 218493007919 catalytic residues [active] 218493007922 6 probable transmembrane helices predicted for SBG1475 by TMHMM2.0 at aa 5-27, 47-69, 82-104, 175-194,215-234 and 239-261 218493007925 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 218493007926 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218493007927 Putative methyltransferase; Region: Methyltransf_20; pfam12147 218493007928 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218493007929 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218493007930 putative acyl-acceptor binding pocket; other site 218493007932 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 218493007933 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 218493007936 7 probable transmembrane helices predicted for SBG1478 by TMHMM2.0 at aa 52-71, 91-113, 146-168, 189-211,216-238, 259-281 and 285-307 218493007938 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 218493007940 4 probable transmembrane helices predicted for SBG1479 by TMHMM2.0 at aa 39-61, 116-135, 155-172 and 177-199 218493007942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 218493007943 signal peptide predicted for SBG1480 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493007945 1 probable transmembrane helix predicted for SBG1480 by TMHMM2.0 at aa 5-24 218493007946 signal peptide predicted for SBG1481 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.600 between residues 26 and 27 218493007947 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 218493007949 signal peptide predicted for SBG1482 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.593 between residues 34 and 35 218493007950 hypothetical protein; Provisional; Region: PRK10695 218493007951 1 probable transmembrane helix predicted for SBG1482 by TMHMM2.0 at aa 7-29 218493007952 1 probable transmembrane helix predicted for SBG1483 by TMHMM2.0 at aa 13-35 218493007953 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 218493007954 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 218493007955 putative ligand binding site [chemical binding]; other site 218493007956 putative NAD binding site [chemical binding]; other site 218493007957 catalytic site [active] 218493007964 heat-inducible protein; Provisional; Region: PRK10449 218493007965 signal peptide predicted for SBG1485 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.359 between residues 20 and 21 218493007968 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 218493007969 Domain of unknown function (DUF333); Region: DUF333; pfam03891 218493007970 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 218493007971 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 218493007972 dimer interface [polypeptide binding]; other site 218493007973 PYR/PP interface [polypeptide binding]; other site 218493007974 TPP binding site [chemical binding]; other site 218493007975 substrate binding site [chemical binding]; other site 218493007976 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 218493007977 Domain of unknown function; Region: EKR; smart00890 218493007978 4Fe-4S binding domain; Region: Fer4_6; pfam12837 218493007979 4Fe-4S binding domain; Region: Fer4; pfam00037 218493007980 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 218493007981 TPP-binding site [chemical binding]; other site 218493007982 dimer interface [polypeptide binding]; other site 218493007991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493007992 Ligand Binding Site [chemical binding]; other site 218493007994 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 218493007995 4 probable transmembrane helices predicted for SBG1490 by TMHMM2.0 at aa 5-22, 32-51, 58-80 and 85-107 218493007999 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 218493008000 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 218493008001 Ligand Binding Site [chemical binding]; other site 218493008003 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 218493008004 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218493008005 ATP binding site [chemical binding]; other site 218493008006 Mg++ binding site [ion binding]; other site 218493008007 motif III; other site 218493008008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493008009 nucleotide binding region [chemical binding]; other site 218493008010 ATP-binding site [chemical binding]; other site 218493008011 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 218493008012 putative RNA binding site [nucleotide binding]; other site 218493008018 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 218493008019 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 218493008020 Cl binding site [ion binding]; other site 218493008021 oligomer interface [polypeptide binding]; other site 218493008023 2 probable transmembrane helices predicted for SBG1496 by TMHMM2.0 at aa 272-294 and 299-321 218493008024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218493008025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493008026 dimer interface [polypeptide binding]; other site 218493008027 putative CheW interface [polypeptide binding]; other site 218493008030 2 probable transmembrane helices predicted for SBG1497 by TMHMM2.0 at aa 13-30 and 40-62 218493008031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 218493008032 Smr domain; Region: Smr; pfam01713 218493008035 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 218493008036 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218493008037 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218493008038 DNA binding site [nucleotide binding] 218493008039 active site 218493008043 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 218493008044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218493008045 ligand binding site [chemical binding]; other site 218493008046 flexible hinge region; other site 218493008047 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 218493008048 putative switch regulator; other site 218493008049 non-specific DNA interactions [nucleotide binding]; other site 218493008050 DNA binding site [nucleotide binding] 218493008051 sequence specific DNA binding site [nucleotide binding]; other site 218493008052 putative cAMP binding site [chemical binding]; other site 218493008056 universal stress protein UspE; Provisional; Region: PRK11175 218493008057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493008058 Ligand Binding Site [chemical binding]; other site 218493008059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493008060 Ligand Binding Site [chemical binding]; other site 218493008063 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 218493008064 signal peptide predicted for SBG1503 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.537 between residues 31 and 32 218493008065 2 probable transmembrane helices predicted for SBG1503 by TMHMM2.0 at aa 13-35 and 60-82 218493008066 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 218493008067 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493008069 5 probable transmembrane helices predicted for SBG1504 by TMHMM2.0 at aa 10-30, 39-61, 76-98, 117-134 and 138-160 218493008072 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 218493008073 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 218493008074 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 218493008077 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 218493008078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493008079 non-specific DNA binding site [nucleotide binding]; other site 218493008080 salt bridge; other site 218493008081 sequence-specific DNA binding site [nucleotide binding]; other site 218493008082 Cupin domain; Region: Cupin_2; pfam07883 218493008085 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 218493008086 B3/4 domain; Region: B3_4; pfam03483 218493008088 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 218493008090 signal peptide predicted for SBG1510 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.777 between residues 24 and 25 218493008091 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 218493008092 signal peptide predicted for SBG1512 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.784 between residues 22 and 23 218493008093 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 218493008094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493008095 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 218493008100 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 218493008101 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 218493008102 putative NAD(P) binding site [chemical binding]; other site 218493008105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493008106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493008107 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 218493008108 putative effector binding pocket; other site 218493008109 putative dimerization interface [polypeptide binding]; other site 218493008112 signal peptide predicted for SBG1516 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.394 between residues 25 and 26 218493008113 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493008115 1 probable transmembrane helix predicted for SBG1516 by TMHMM2.0 at aa 4-26 218493008117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218493008118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493008120 oxidoreductase; Provisional; Region: PRK12742 218493008121 classical (c) SDRs; Region: SDR_c; cd05233 218493008122 NAD(P) binding site [chemical binding]; other site 218493008123 active site 218493008126 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493008127 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493008128 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493008129 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 218493008130 substrate binding site [chemical binding]; other site 218493008131 dimer interface [polypeptide binding]; other site 218493008132 ATP binding site [chemical binding]; other site 218493008136 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218493008137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008138 dimer interface [polypeptide binding]; other site 218493008139 conserved gate region; other site 218493008140 ABC-ATPase subunit interface; other site 218493008141 6 probable transmembrane helices predicted for SBG1520 by TMHMM2.0 at aa 20-39, 54-76, 83-105, 120-142,214-236 and 275-297 218493008144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218493008145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218493008146 6 probable transmembrane helices predicted for SBG1521 by TMHMM2.0 at aa 13-35, 81-103, 110-129, 144-166,187-209 and 267-289 218493008150 signal peptide predicted for SBG1522 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 23 and 24 218493008151 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218493008153 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 218493008156 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218493008157 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218493008158 Walker A/P-loop; other site 218493008159 ATP binding site [chemical binding]; other site 218493008160 Q-loop/lid; other site 218493008161 ABC transporter signature motif; other site 218493008162 Walker B; other site 218493008163 D-loop; other site 218493008164 H-loop/switch region; other site 218493008165 TOBE domain; Region: TOBE_2; pfam08402 218493008170 The CDS carries a frameshift mutation and has undergone a deletion removing the 5' end of the gene 218493008174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493008175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493008176 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 218493008177 putative effector binding pocket; other site 218493008178 putative dimerization interface [polypeptide binding]; other site 218493008182 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 218493008183 NmrA-like family; Region: NmrA; pfam05368 218493008184 NAD(P) binding site [chemical binding]; other site 218493008185 active site lysine 218493008187 signal peptide predicted for SBG1529 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.935 between residues 22 and 23 218493008188 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218493008189 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218493008190 peptide binding site [polypeptide binding]; other site 218493008193 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 218493008194 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 218493008195 putative active site [active] 218493008196 Zn binding site [ion binding]; other site 218493008198 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 218493008199 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 218493008200 active site 218493008205 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 218493008206 dimer interface [polypeptide binding]; other site 218493008207 catalytic triad [active] 218493008208 peroxidatic and resolving cysteines [active] 218493008211 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 218493008212 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 218493008213 putative aromatic amino acid binding site; other site 218493008214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493008215 Walker A motif; other site 218493008216 ATP binding site [chemical binding]; other site 218493008217 Walker B motif; other site 218493008218 arginine finger; other site 218493008224 hypothetical protein; Provisional; Region: PRK05415 218493008225 TIGR01620 family protein; Region: hyp_HI0043 218493008227 3 probable transmembrane helices predicted for SBG1534 by TMHMM2.0 at aa 70-89, 99-121 and 210-232 218493008228 Predicted ATPase [General function prediction only]; Region: COG3106 218493008231 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493008232 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493008233 DNA binding site [nucleotide binding] 218493008234 domain linker motif; other site 218493008235 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 218493008236 putative dimerization interface [polypeptide binding]; other site 218493008237 putative ligand binding site [chemical binding]; other site 218493008241 signal peptide predicted for SBG1537 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.858 between residues 21 and 22 218493008242 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 218493008244 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218493008245 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218493008246 Walker A/P-loop; other site 218493008247 ATP binding site [chemical binding]; other site 218493008248 Q-loop/lid; other site 218493008249 ABC transporter signature motif; other site 218493008250 Walker B; other site 218493008251 D-loop; other site 218493008252 H-loop/switch region; other site 218493008253 TOBE domain; Region: TOBE_2; pfam08402 218493008258 beta-phosphoglucomutase; Region: bPGM; TIGR01990 218493008259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493008260 motif II; other site 218493008262 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 218493008263 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 218493008264 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 218493008265 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 218493008269 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218493008270 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218493008271 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218493008274 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 218493008276 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493008277 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 218493008278 putative NAD(P) binding site [chemical binding]; other site 218493008280 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218493008281 signal peptide predicted for SBG1544 by SignalP 2.0 HMM (Signal peptide probabilty 0.875) with cleavage site probability 0.697 between residues 39 and 40 218493008282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008283 dimer interface [polypeptide binding]; other site 218493008284 conserved gate region; other site 218493008285 putative PBP binding loops; other site 218493008286 ABC-ATPase subunit interface; other site 218493008288 6 probable transmembrane helices predicted for SBG1544 by TMHMM2.0 at aa 12-34, 78-100, 117-139, 143-165,186-208 and 242-264 218493008290 signal peptide predicted for SBG1545 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.709 between residues 30 and 31 218493008291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008292 dimer interface [polypeptide binding]; other site 218493008293 conserved gate region; other site 218493008294 putative PBP binding loops; other site 218493008295 ABC-ATPase subunit interface; other site 218493008297 6 probable transmembrane helices predicted for SBG1545 by TMHMM2.0 at aa 13-35, 76-98, 110-127, 164-186,208-230 and 265-282 218493008299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218493008300 signal peptide predicted for SBG1546 by SignalP 2.0 HMM (Signal peptide probabilty 0.919) with cleavage site probability 0.687 between residues 20 and 21 218493008301 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218493008304 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 218493008305 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 218493008306 active site 218493008307 homodimer interface [polypeptide binding]; other site 218493008308 catalytic site [active] 218493008310 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 218493008311 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 218493008312 phage shock protein C; Region: phageshock_pspC; TIGR02978 218493008314 1 probable transmembrane helix predicted for SBG1549 by TMHMM2.0 at aa 39-61 218493008315 phage shock protein B; Provisional; Region: pspB; PRK09458 218493008317 1 probable transmembrane helix predicted for SBG1550 by TMHMM2.0 at aa 4-26 218493008318 phage shock protein PspA; Provisional; Region: PRK10698 218493008320 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 218493008321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493008322 Walker A motif; other site 218493008323 ATP binding site [chemical binding]; other site 218493008324 Walker B motif; other site 218493008325 arginine finger; other site 218493008326 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218493008331 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218493008332 signal peptide predicted for SBG1553 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.669 between residues 20 and 21 218493008333 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 218493008334 peptide binding site [polypeptide binding]; other site 218493008336 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 218493008337 signal peptide predicted for SBG1554 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.605 between residues 37 and 38 218493008338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008339 dimer interface [polypeptide binding]; other site 218493008340 conserved gate region; other site 218493008341 putative PBP binding loops; other site 218493008342 ABC-ATPase subunit interface; other site 218493008343 5 probable transmembrane helices predicted for SBG1554 by TMHMM2.0 at aa 9-31, 80-102, 114-136, 251-273 and 286-308 218493008345 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 218493008346 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218493008347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008348 dimer interface [polypeptide binding]; other site 218493008349 conserved gate region; other site 218493008350 putative PBP binding loops; other site 218493008351 ABC-ATPase subunit interface; other site 218493008352 6 probable transmembrane helices predicted for SBG1555 by TMHMM2.0 at aa 30-52, 99-121, 134-156, 198-217,224-243 and 258-280 218493008354 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 218493008355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493008356 Walker A/P-loop; other site 218493008357 ATP binding site [chemical binding]; other site 218493008358 Q-loop/lid; other site 218493008359 ABC transporter signature motif; other site 218493008360 Walker B; other site 218493008361 D-loop; other site 218493008362 H-loop/switch region; other site 218493008363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218493008367 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 218493008368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493008369 Walker A/P-loop; other site 218493008370 ATP binding site [chemical binding]; other site 218493008371 Q-loop/lid; other site 218493008372 ABC transporter signature motif; other site 218493008373 Walker B; other site 218493008374 D-loop; other site 218493008375 H-loop/switch region; other site 218493008379 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 218493008381 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 218493008382 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 218493008383 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 218493008384 NAD binding site [chemical binding]; other site 218493008385 homotetramer interface [polypeptide binding]; other site 218493008386 homodimer interface [polypeptide binding]; other site 218493008387 substrate binding site [chemical binding]; other site 218493008388 active site 218493008390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 218493008391 exoribonuclease II; Provisional; Region: PRK05054 218493008392 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 218493008393 RNB domain; Region: RNB; pfam00773 218493008394 S1 RNA binding domain; Region: S1; pfam00575 218493008399 RNase II stability modulator; Provisional; Region: PRK10060 218493008400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493008401 putative active site [active] 218493008402 heme pocket [chemical binding]; other site 218493008403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493008404 metal binding site [ion binding]; metal-binding site 218493008405 active site 218493008406 I-site; other site 218493008407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493008412 hypothetical protein; Provisional; Region: PRK13658 218493008413 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493008414 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493008415 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493008418 lipoprotein; Provisional; Region: PRK10540 218493008419 signal peptide predicted for SBG1568 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.666 between residues 23 and 24 218493008421 translation initiation factor Sui1; Validated; Region: PRK06824 218493008422 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 218493008423 putative rRNA binding site [nucleotide binding]; other site 218493008426 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 218493008427 active site 218493008428 dimer interface [polypeptide binding]; other site 218493008431 signal peptide predicted for SBG1571 by SignalP 2.0 HMM (Signal peptide probabilty 0.622) with cleavage site probability 0.544 between residues 24 and 25 218493008432 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 218493008433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493008434 binding surface 218493008435 TPR motif; other site 218493008437 Predicted membrane protein [Function unknown]; Region: COG3771 218493008438 signal peptide predicted for SBG1572 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.608 between residues 22 and 23 218493008440 2 probable transmembrane helices predicted for SBG1572 by TMHMM2.0 at aa 5-23 and 43-65 218493008441 signal peptide predicted for SBG1573 by SignalP 2.0 HMM (Signal peptide probabilty 0.816) with cleavage site probability 0.550 between residues 21 and 22 218493008442 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493008443 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 218493008444 active site 218493008446 6 probable transmembrane helices predicted for SBG1573 by TMHMM2.0 at aa 7-29, 49-68, 75-92, 157-179,186-208 and 212-229 218493008447 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 218493008448 dimerization interface [polypeptide binding]; other site 218493008449 active site 218493008452 aconitate hydratase; Validated; Region: PRK09277 218493008453 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 218493008454 substrate binding site [chemical binding]; other site 218493008455 ligand binding site [chemical binding]; other site 218493008456 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 218493008457 substrate binding site [chemical binding]; other site 218493008463 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 218493008464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493008465 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 218493008466 substrate binding site [chemical binding]; other site 218493008467 putative dimerization interface [polypeptide binding]; other site 218493008472 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 218493008473 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 218493008474 active site 218493008475 interdomain interaction site; other site 218493008476 putative metal-binding site [ion binding]; other site 218493008477 nucleotide binding site [chemical binding]; other site 218493008478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218493008479 domain I; other site 218493008480 DNA binding groove [nucleotide binding] 218493008481 phosphate binding site [ion binding]; other site 218493008482 domain II; other site 218493008483 domain III; other site 218493008484 nucleotide binding site [chemical binding]; other site 218493008485 catalytic site [active] 218493008486 domain IV; other site 218493008487 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218493008488 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218493008489 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 218493008490 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 218493008498 hypothetical protein; Provisional; Region: PRK11037 218493008499 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 218493008500 putative inner membrane peptidase; Provisional; Region: PRK11778 218493008501 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 218493008502 tandem repeat interface [polypeptide binding]; other site 218493008503 oligomer interface [polypeptide binding]; other site 218493008504 active site residues [active] 218493008506 2 probable transmembrane helices predicted for SBG1579 by TMHMM2.0 at aa 10-32 and 189-206 218493008510 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 218493008511 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 218493008512 NADP binding site [chemical binding]; other site 218493008513 homodimer interface [polypeptide binding]; other site 218493008514 active site 218493008517 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 218493008518 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 218493008519 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 218493008520 homodimer interface [polypeptide binding]; other site 218493008521 Walker A motif; other site 218493008522 ATP binding site [chemical binding]; other site 218493008523 hydroxycobalamin binding site [chemical binding]; other site 218493008524 Walker B motif; other site 218493008526 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 218493008527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493008528 RNA binding surface [nucleotide binding]; other site 218493008529 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 218493008530 probable active site [active] 218493008534 hypothetical protein; Provisional; Region: PRK11630 218493008537 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 218493008538 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 218493008539 active site 218493008540 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 218493008542 anthranilate synthase component I; Provisional; Region: PRK13564 218493008543 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 218493008544 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 218493008547 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 218493008548 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218493008549 glutamine binding [chemical binding]; other site 218493008550 catalytic triad [active] 218493008551 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218493008552 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 218493008558 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 218493008559 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 218493008560 active site 218493008561 ribulose/triose binding site [chemical binding]; other site 218493008562 phosphate binding site [ion binding]; other site 218493008563 substrate (anthranilate) binding pocket [chemical binding]; other site 218493008564 product (indole) binding pocket [chemical binding]; other site 218493008565 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 218493008566 active site 218493008570 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 218493008571 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 218493008572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493008573 catalytic residue [active] 218493008576 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 218493008577 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 218493008578 substrate binding site [chemical binding]; other site 218493008579 active site 218493008580 catalytic residues [active] 218493008581 heterodimer interface [polypeptide binding]; other site 218493008584 General stress protein [General function prediction only]; Region: GsiB; COG3729 218493008585 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 218493008586 dimerization interface [polypeptide binding]; other site 218493008587 metal binding site [ion binding]; metal-binding site 218493008589 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 218493008590 dinuclear metal binding motif [ion binding]; other site 218493008592 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 218493008593 dimanganese center [ion binding]; other site 218493008595 outer membrane protein W; Provisional; Region: PRK10959 218493008596 signal peptide predicted for SBG1594 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 21 and 22 218493008598 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 218493008600 signal peptide predicted for SBG1596 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.697 between residues 46 and 47 218493008601 hypothetical protein; Provisional; Region: PRK02868 218493008603 6 probable transmembrane helices predicted for SBG1596 by TMHMM2.0 at aa 20-42, 89-111, 118-140, 144-166,187-209 and 219-241 218493008604 intracellular septation protein A; Reviewed; Region: PRK00259 218493008606 5 probable transmembrane helices predicted for SBG1597 by TMHMM2.0 at aa 20-42, 51-68, 78-95, 119-141 and 151-170 218493008607 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 218493008609 transport protein TonB; Provisional; Region: PRK10819 218493008610 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218493008612 YciI-like protein; Reviewed; Region: PRK11370 218493008614 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 218493008615 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 218493008616 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 218493008617 putative active site [active] 218493008618 catalytic site [active] 218493008619 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 218493008620 putative active site [active] 218493008621 catalytic site [active] 218493008622 2 probable transmembrane helices predicted for SBG1601 by TMHMM2.0 at aa 10-29 and 36-58 218493008626 dsDNA-mimic protein; Reviewed; Region: PRK05094 218493008628 Ion transport protein; Region: Ion_trans; pfam00520 218493008629 Ion channel; Region: Ion_trans_2; pfam07885 218493008630 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 218493008631 Double zinc ribbon; Region: DZR; pfam12773 218493008632 6 probable transmembrane helices predicted for SBG1603 by TMHMM2.0 at aa 30-52, 62-84, 91-113, 157-179,184-206 and 216-238 218493008634 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 218493008635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493008636 Walker A/P-loop; other site 218493008637 ATP binding site [chemical binding]; other site 218493008638 Q-loop/lid; other site 218493008639 ABC transporter signature motif; other site 218493008640 Walker B; other site 218493008641 D-loop; other site 218493008642 H-loop/switch region; other site 218493008643 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218493008648 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 218493008649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493008650 Walker A/P-loop; other site 218493008651 ATP binding site [chemical binding]; other site 218493008652 Q-loop/lid; other site 218493008653 ABC transporter signature motif; other site 218493008654 Walker B; other site 218493008655 D-loop; other site 218493008656 H-loop/switch region; other site 218493008657 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218493008662 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 218493008663 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218493008664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008665 dimer interface [polypeptide binding]; other site 218493008666 conserved gate region; other site 218493008667 ABC-ATPase subunit interface; other site 218493008669 6 probable transmembrane helices predicted for SBG1606 by TMHMM2.0 at aa 37-59, 103-125, 138-160,164-183, 214-236 and 268-290 218493008671 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 218493008672 signal peptide predicted for SBG1607 by SignalP 2.0 HMM (Signal peptide probabilty 0.733) with cleavage site probability 0.372 between residues 32 and 33 218493008673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493008674 dimer interface [polypeptide binding]; other site 218493008675 conserved gate region; other site 218493008676 putative PBP binding loops; other site 218493008677 ABC-ATPase subunit interface; other site 218493008679 6 probable transmembrane helices predicted for SBG1607 by TMHMM2.0 at aa 13-30, 102-121, 134-156,166-188, 228-250 and 278-300 218493008681 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218493008682 signal peptide predicted for SBG1608 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 26 and 27 218493008683 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218493008684 peptide binding site [polypeptide binding]; other site 218493008687 hypothetical protein; Provisional; Region: PRK11111 218493008688 6 probable transmembrane helices predicted for SBG1610 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142,146-168 and 189-211 218493008691 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 218493008692 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 218493008693 putative catalytic cysteine [active] 218493008694 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 218493008695 putative active site [active] 218493008696 metal binding site [ion binding]; metal-binding site 218493008701 thymidine kinase; Provisional; Region: PRK04296 218493008704 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 218493008705 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 218493008707 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 218493008708 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 218493008709 active site 218493008710 tetramer interface; other site 218493008713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493008714 active site 218493008715 response regulator of RpoS; Provisional; Region: PRK10693 218493008716 phosphorylation site [posttranslational modification] 218493008717 intermolecular recognition site; other site 218493008718 dimerization interface [polypeptide binding]; other site 218493008720 hypothetical protein; Provisional; Region: PRK10279 218493008721 signal peptide predicted for SBG1616 by SignalP 2.0 HMM (Signal peptide probabilty 0.631) with cleavage site probability 0.137 between residues 17 and 18 218493008722 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 218493008723 active site 218493008724 nucleophile elbow; other site 218493008728 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 218493008729 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 218493008730 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 218493008731 putative active site [active] 218493008732 putative substrate binding site [chemical binding]; other site 218493008733 putative cosubstrate binding site; other site 218493008734 catalytic site [active] 218493008737 Predicted ATPase [General function prediction only]; Region: COG3911 218493008738 AAA domain; Region: AAA_28; pfam13521 218493008740 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 218493008742 5 probable transmembrane helices predicted for SBG1619 by TMHMM2.0 at aa 4-26, 47-69, 89-108, 127-149 and 184-206 218493008743 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 218493008745 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 218493008746 4Fe-4S binding domain; Region: Fer4; cl02805 218493008749 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 218493008750 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 218493008751 [4Fe-4S] binding site [ion binding]; other site 218493008752 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493008753 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493008754 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493008755 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 218493008756 molybdopterin cofactor binding site; other site 218493008764 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 218493008765 12 probable transmembrane helices predicted for SBG1623 by TMHMM2.0 at aa 38-60, 75-97, 104-123,133-155, 176-198, 213-235, 256-278, 288-310, 322-344,348-370, 404-421 and 436-458 218493008767 signal peptide predicted for SBG1624 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.456 between residues 33 and 34 218493008768 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 218493008769 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 218493008770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493008771 dimerization interface [polypeptide binding]; other site 218493008772 Histidine kinase; Region: HisKA_3; pfam07730 218493008773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493008774 ATP binding site [chemical binding]; other site 218493008775 Mg2+ binding site [ion binding]; other site 218493008776 G-X-G motif; other site 218493008777 2 probable transmembrane helices predicted for SBG1624 by TMHMM2.0 at aa 15-37 and 154-176 218493008781 transcriptional regulator NarL; Provisional; Region: PRK10651 218493008782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493008783 active site 218493008784 phosphorylation site [posttranslational modification] 218493008785 intermolecular recognition site; other site 218493008786 dimerization interface [polypeptide binding]; other site 218493008787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493008788 DNA binding residues [nucleotide binding] 218493008789 dimerization interface [polypeptide binding]; other site 218493008793 putative invasin; Provisional; Region: PRK10177 218493008794 signal peptide predicted for SBG1626 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.862 between residues 24 and 25 218493008795 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 218493008796 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 218493008798 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 218493008799 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 218493008800 putative active site pocket [active] 218493008801 dimerization interface [polypeptide binding]; other site 218493008802 putative catalytic residue [active] 218493008804 cation transport regulator; Reviewed; Region: chaB; PRK09582 218493008806 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 218493008807 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218493008808 11 probable transmembrane helices predicted for SBG1630 by TMHMM2.0 at aa 13-32, 36-58, 71-93,108-127, 139-161, 166-188, 220-237, 247-269, 290-312,317-339 and 346-365 218493008810 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 218493008811 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218493008813 hypothetical protein; Provisional; Region: PRK10941 218493008814 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 218493008816 hypothetical protein; Provisional; Region: PRK10278 218493008818 4 probable transmembrane helices predicted for SBG1633 by TMHMM2.0 at aa 4-26, 38-60, 70-92 and 104-123 218493008819 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 218493008820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493008823 peptide chain release factor 1; Validated; Region: prfA; PRK00591 218493008824 This domain is found in peptide chain release factors; Region: PCRF; smart00937 218493008825 RF-1 domain; Region: RF-1; pfam00472 218493008829 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 218493008830 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 218493008831 tRNA; other site 218493008832 putative tRNA binding site [nucleotide binding]; other site 218493008833 putative NADP binding site [chemical binding]; other site 218493008834 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 218493008840 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 218493008841 signal peptide predicted for SBG1638 by SignalP 2.0 HMM (Signal peptide probabilty 0.897) with cleavage site probability 0.787 between residues 28 and 29 218493008842 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 218493008845 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 218493008846 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 218493008847 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218493008850 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 218493008851 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 218493008852 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493008853 active site 218493008858 putative transporter; Provisional; Region: PRK11660 218493008859 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 218493008860 Sulfate transporter family; Region: Sulfate_transp; pfam00916 218493008861 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 218493008862 11 probable transmembrane helices predicted for SBG1641 by TMHMM2.0 at aa 34-56, 61-83, 98-120,127-149, 177-199, 212-234, 277-299, 319-341, 346-368,370-388 and 408-439 218493008867 hypothetical protein; Provisional; Region: PRK10692 218493008868 signal peptide predicted for SBG1642 by SignalP 2.0 HMM (Signal peptide probabilty 0.893) with cleavage site probability 0.329 between residues 24 and 25 218493008869 2 probable transmembrane helices predicted for SBG1642 by TMHMM2.0 at aa 7-29 and 39-61 218493008870 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 218493008871 putative active site [active] 218493008872 catalytic residue [active] 218493008876 GTP-binding protein YchF; Reviewed; Region: PRK09601 218493008877 YchF GTPase; Region: YchF; cd01900 218493008878 G1 box; other site 218493008879 GTP/Mg2+ binding site [chemical binding]; other site 218493008880 Switch I region; other site 218493008881 G2 box; other site 218493008882 Switch II region; other site 218493008883 G3 box; other site 218493008884 G4 box; other site 218493008885 G5 box; other site 218493008886 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 218493008891 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 218493008892 hya operon 218493008893 signal peptide predicted for SBG1646 by SignalP 2.0 HMM (Signal peptide probabilty 0.853) with cleavage site probability 0.738 between residues 45 and 46 218493008894 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 218493008895 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 218493008896 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 218493008898 1 probable transmembrane helix predicted for SBG1646 by TMHMM2.0 at aa 20-39 218493008900 hydrogenase 1 large subunit; Provisional; Region: PRK10170 218493008901 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 218493008905 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 218493008907 4 probable transmembrane helices predicted for SBG1648 by TMHMM2.0 at aa 28-47, 67-89, 141-160 and 194-211 218493008909 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 218493008910 putative substrate-binding site; other site 218493008911 nickel binding site [ion binding]; other site 218493008913 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 218493008915 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 218493008916 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 218493008918 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 218493008919 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 218493008921 9 probable transmembrane helices predicted for SBG1652 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 125-147,186-208, 215-237, 387-409, 421-443 and 471-493 218493008922 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218493008923 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 218493008925 8 probable transmembrane helices predicted for SBG1653 by TMHMM2.0 at aa 7-24, 80-102, 123-145, 165-187,208-230, 261-283, 292-314 and 334-356 218493008927 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 218493008928 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 218493008929 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 218493008930 NAD(P) binding site [chemical binding]; other site 218493008935 trehalase; Provisional; Region: treA; PRK13271 218493008936 signal peptide predicted for SBG1655 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 35 and 36 218493008937 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 218493008941 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 218493008943 3 probable transmembrane helices predicted for SBG1656 by TMHMM2.0 at aa 4-22, 27-49 and 59-81 218493008944 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 218493008945 Flagellar regulator YcgR; Region: YcgR; pfam07317 218493008946 PilZ domain; Region: PilZ; pfam07238 218493008949 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 218493008950 signal peptide predicted for SBG1658 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.494 between residues 18 and 19 218493008951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493008952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493008953 catalytic residue [active] 218493008957 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 218493008958 dimer interface [polypeptide binding]; other site 218493008959 catalytic triad [active] 218493008962 signal peptide predicted for SBG1660 by SignalP 2.0 HMM (Signal peptide probabilty 0.651) with cleavage site probability 0.147 between residues 29 and 30 218493008963 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 218493008964 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 218493008965 TrkA-C domain; Region: TrkA_C; pfam02080 218493008966 Transporter associated domain; Region: CorC_HlyC; smart01091 218493008967 11 probable transmembrane helices predicted for SBG1660 by TMHMM2.0 at aa 4-26, 31-53, 57-74, 87-109,119-141, 187-209, 232-254, 267-289, 299-321, 334-356 and 361-383 218493008971 alanine racemase; Reviewed; Region: dadX; PRK03646 218493008972 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 218493008973 active site 218493008974 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218493008975 substrate binding site [chemical binding]; other site 218493008976 catalytic residues [active] 218493008977 dimer interface [polypeptide binding]; other site 218493008981 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 218493008982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493008985 SpoVR family protein; Provisional; Region: PRK11767 218493008986 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 218493008988 fatty acid metabolism regulator; Provisional; Region: PRK04984 218493008989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493008990 DNA-binding site [nucleotide binding]; DNA binding site 218493008991 FadR C-terminal domain; Region: FadR_C; pfam07840 218493008995 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218493008996 transmembrane helices; other site 218493008998 12 probable transmembrane helices predicted for SBG1665 by TMHMM2.0 at aa 26-48, 61-80, 95-117,122-144, 148-165, 197-219, 239-261, 299-331, 346-368,389-411, 453-472 and 479-501 218493008999 disulfide bond formation protein B; Provisional; Region: PRK01749 218493009000 signal peptide predicted for SBG1666 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.910 between residues 24 and 25 218493009002 4 probable transmembrane helices predicted for SBG1666 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 144-166 218493009003 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 218493009005 hypothetical protein; Provisional; Region: PRK05170 218493009007 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 218493009008 hypothetical protein; Provisional; Region: PRK10691 218493009010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 218493009012 septum formation inhibitor; Reviewed; Region: minC; PRK03511 218493009013 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 218493009014 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 218493009017 cell division inhibitor MinD; Provisional; Region: PRK10818 218493009018 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 218493009019 Switch I; other site 218493009020 Switch II; other site 218493009023 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 218493009025 ribonuclease D; Provisional; Region: PRK10829 218493009026 signal peptide predicted for SBG1674 by SignalP 2.0 HMM (Signal peptide probabilty 0.745) with cleavage site probability 0.742 between residues 26 and 27 218493009027 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 218493009028 catalytic site [active] 218493009029 putative active site [active] 218493009030 putative substrate binding site [chemical binding]; other site 218493009031 HRDC domain; Region: HRDC; cl02578 218493009034 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 218493009035 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 218493009036 acyl-activating enzyme (AAE) consensus motif; other site 218493009037 putative AMP binding site [chemical binding]; other site 218493009038 putative active site [active] 218493009039 putative CoA binding site [chemical binding]; other site 218493009043 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 218493009044 signal peptide predicted for SBG1676 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.255 between residues 24 and 25 218493009047 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 218493009048 Glycoprotease family; Region: Peptidase_M22; pfam00814 218493009050 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 218493009051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 218493009052 DEAD_2; Region: DEAD_2; pfam06733 218493009053 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 218493009057 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 218493009058 homotrimer interaction site [polypeptide binding]; other site 218493009059 putative active site [active] 218493009062 hypothetical protein; Provisional; Region: PRK05114 218493009064 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 218493009065 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 218493009066 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 218493009069 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 218493009070 putative active site [active] 218493009071 putative CoA binding site [chemical binding]; other site 218493009072 nudix motif; other site 218493009073 metal binding site [ion binding]; metal-binding site 218493009076 L-serine deaminase; Provisional; Region: PRK15023 218493009077 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218493009078 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218493009082 phage resistance protein; Provisional; Region: PRK10551 218493009083 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218493009084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493009085 1 probable transmembrane helix predicted for SBG1684 by TMHMM2.0 at aa 13-35 218493009087 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218493009088 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218493009089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218493009090 Transporter associated domain; Region: CorC_HlyC; smart01091 218493009093 7 probable transmembrane helices predicted for SBG1685 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145,150-172, 185-207 and 212-231 218493009095 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 218493009096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493009097 active pocket/dimerization site; other site 218493009098 active site 218493009099 phosphorylation site [posttranslational modification] 218493009100 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218493009101 active site 218493009102 phosphorylation site [posttranslational modification] 218493009105 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 218493009107 7 probable transmembrane helices predicted for SBG1687 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117,143-165, 178-200 and 215-237 218493009109 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 218493009111 5 probable transmembrane helices predicted for SBG1688 by TMHMM2.0 at aa 102-124, 139-161, 182-204,233-255 and 262-281 218493009113 hypothetical protein; Provisional; Region: PRK02913 218493009115 2 probable transmembrane helices predicted for SBG1689 by TMHMM2.0 at aa 7-26 and 65-87 218493009116 hypothetical protein; Provisional; Region: PRK11469 218493009117 Domain of unknown function DUF; Region: DUF204; pfam02659 218493009118 Domain of unknown function DUF; Region: DUF204; pfam02659 218493009119 6 probable transmembrane helices predicted for SBG1690 by TMHMM2.0 at aa 20-42, 55-77, 82-104, 124-146,151-173 and 186-203 218493009123 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 218493009124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493009125 S-adenosylmethionine binding site [chemical binding]; other site 218493009127 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 218493009128 signal peptide predicted for SBG1692 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.629 between residues 38 and 39 218493009129 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218493009130 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218493009133 1 probable transmembrane helix predicted for SBG1692 by TMHMM2.0 at aa 16-38 218493009134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493009135 DNA-binding site [nucleotide binding]; DNA binding site 218493009136 RNA-binding motif; other site 218493009139 signal peptide predicted for SBG1694 by SignalP 2.0 HMM (Signal peptide probabilty 0.690) with cleavage site probability 0.352 between residues 23 and 24 218493009140 YebO-like protein; Region: YebO; pfam13974 218493009141 1 probable transmembrane helix predicted for SBG1694 by TMHMM2.0 at aa 10-32 218493009142 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 218493009143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493009144 dimerization interface [polypeptide binding]; other site 218493009145 putative Zn2+ binding site [ion binding]; other site 218493009146 putative DNA binding site [nucleotide binding]; other site 218493009147 Bacterial transcriptional regulator; Region: IclR; pfam01614 218493009151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493009152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493009153 putative substrate translocation pore; other site 218493009154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493009155 12 probable transmembrane helices predicted for SBG1696 by TMHMM2.0 at aa 21-43, 53-75, 87-109,113-132, 144-166, 171-193, 205-227, 231-249, 269-291,306-328, 335-357 and 426-448 218493009157 heat shock protein HtpX; Provisional; Region: PRK05457 218493009158 signal peptide predicted for SBG1697 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.420 between residues 63 and 64 218493009161 4 probable transmembrane helices predicted for SBG1697 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 218493009163 IS200 218493009164 Transposase IS200 like; Region: Y1_Tnp; pfam01797 218493009166 signal peptide predicted for SBG1699 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493009167 carboxy-terminal protease; Provisional; Region: PRK11186 218493009168 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 218493009169 protein binding site [polypeptide binding]; other site 218493009170 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 218493009171 Catalytic dyad [active] 218493009172 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 218493009175 ProP expression regulator; Provisional; Region: PRK04950 218493009176 ProQ/FINO family; Region: ProQ; pfam04352 218493009178 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 218493009179 GAF domain; Region: GAF_2; pfam13185 218493009181 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 218493009182 Paraquat-inducible protein A; Region: PqiA; pfam04403 218493009183 Paraquat-inducible protein A; Region: PqiA; pfam04403 218493009185 8 probable transmembrane helices predicted for SBG1702 by TMHMM2.0 at aa 65-84, 119-141, 162-184,188-210, 268-290, 310-339, 351-373 and 383-405 218493009187 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 218493009188 mce related protein; Region: MCE; pfam02470 218493009189 mce related protein; Region: MCE; pfam02470 218493009190 mce related protein; Region: MCE; pfam02470 218493009191 mce related protein; Region: MCE; pfam02470 218493009192 mce related protein; Region: MCE; pfam02470 218493009193 mce related protein; Region: MCE; pfam02470 218493009194 1 probable transmembrane helix predicted for SBG1703 by TMHMM2.0 at aa 22-41 218493009203 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 218493009204 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 218493009205 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 218493009208 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 218493009210 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 218493009211 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218493009212 active site 218493009213 metal binding site [ion binding]; metal-binding site 218493009216 type III secretion protein SopE2; Provisional; Region: PRK15280 218493009217 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 218493009218 SopE GEF domain; Region: SopE_GEF; pfam07487 218493009221 1 probable transmembrane helix predicted for SBG1708 by TMHMM2.0 at aa 30-61 218493009223 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 218493009224 signal peptide predicted for SBG1709 by SignalP 2.0 HMM (Signal peptide probabilty 0.831) with cleavage site probability 0.599 between residues 22 and 23 218493009225 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218493009227 signal peptide predicted for SBG1710 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 19 and 20 218493009228 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 218493009229 1 probable transmembrane helix predicted for SBG1710 by TMHMM2.0 at aa 5-27 218493009230 signal peptide predicted for SBG1711 by SignalP 2.0 HMM (Signal peptide probabilty 0.733) with cleavage site probability 0.310 between residues 31 and 32 218493009231 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 218493009233 8 probable transmembrane helices predicted for SBG1711 by TMHMM2.0 at aa 10-32, 52-74, 94-113, 120-138,153-175, 195-217, 227-249 and 262-284 218493009236 signal peptide predicted for SBG1712 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.778 between residues 26 and 27 218493009237 hypothetical protein; Provisional; Region: PRK10301 218493009239 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 218493009241 Predicted amidohydrolase [General function prediction only]; Region: COG0388 218493009242 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 218493009245 exodeoxyribonuclease X; Provisional; Region: PRK07983 218493009246 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 218493009247 active site 218493009248 catalytic site [active] 218493009249 substrate binding site [chemical binding]; other site 218493009251 protease 2; Provisional; Region: PRK10115 218493009252 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218493009256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 218493009257 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 218493009258 putative metal binding site [ion binding]; other site 218493009260 1 probable transmembrane helix predicted for SBG1717 by TMHMM2.0 at aa 52-74 218493009261 signal peptide predicted for SBG1718 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.949 between residues 21 and 22 218493009262 hypothetical protein; Provisional; Region: PRK13680 218493009263 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 218493009265 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 218493009266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218493009267 ATP-grasp domain; Region: ATP-grasp; pfam02222 218493009269 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 218493009270 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 218493009271 active site 218493009272 intersubunit interface [polypeptide binding]; other site 218493009273 catalytic residue [active] 218493009277 phosphogluconate dehydratase; Validated; Region: PRK09054 218493009278 6-phosphogluconate dehydratase; Region: edd; TIGR01196 218493009283 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 218493009284 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 218493009285 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 218493009289 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 218493009290 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218493009291 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218493009292 putative active site [active] 218493009295 pyruvate kinase; Provisional; Region: PRK05826 218493009296 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 218493009297 domain interfaces; other site 218493009298 active site 218493009302 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218493009303 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218493009304 putative acyl-acceptor binding pocket; other site 218493009306 1 probable transmembrane helix predicted for SBG1726 by TMHMM2.0 at aa 21-43 218493009307 putative peptidase; Provisional; Region: PRK11649 218493009308 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 218493009309 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493009310 Peptidase family M23; Region: Peptidase_M23; pfam01551 218493009314 1 probable transmembrane helix predicted for SBG1727 by TMHMM2.0 at aa 21-40 218493009315 signal peptide predicted for SBG1728 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.922 between residues 28 and 29 218493009316 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 218493009317 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 218493009318 metal binding site [ion binding]; metal-binding site 218493009320 1 probable transmembrane helix predicted for SBG1728 by TMHMM2.0 at aa 12-34 218493009321 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 218493009322 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218493009325 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218493009326 signal peptide predicted for SBG1730 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.486 between residues 19 and 20 218493009327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493009328 ABC-ATPase subunit interface; other site 218493009329 dimer interface [polypeptide binding]; other site 218493009330 putative PBP binding regions; other site 218493009332 7 probable transmembrane helices predicted for SBG1730 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145,170-192, 213-235 and 239-256 218493009334 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 218493009335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493009336 Walker A motif; other site 218493009337 ATP binding site [chemical binding]; other site 218493009338 Walker B motif; other site 218493009339 arginine finger; other site 218493009340 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 218493009345 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 218493009346 RuvA N terminal domain; Region: RuvA_N; pfam01330 218493009347 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 218493009350 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 218493009351 active site 218493009352 putative DNA-binding cleft [nucleotide binding]; other site 218493009353 dimer interface [polypeptide binding]; other site 218493009356 hypothetical protein; Validated; Region: PRK00110 218493009358 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 218493009359 nudix motif; other site 218493009362 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 218493009363 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 218493009364 dimer interface [polypeptide binding]; other site 218493009365 anticodon binding site; other site 218493009366 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 218493009367 homodimer interface [polypeptide binding]; other site 218493009368 motif 1; other site 218493009369 active site 218493009370 motif 2; other site 218493009371 GAD domain; Region: GAD; pfam02938 218493009372 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218493009373 active site 218493009374 motif 3; other site 218493009380 Isochorismatase family; Region: Isochorismatase; pfam00857 218493009381 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 218493009382 catalytic triad [active] 218493009383 conserved cis-peptide bond; other site 218493009385 hypothetical protein; Provisional; Region: PRK10302 218493009387 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 218493009388 4 probable transmembrane helices predicted for SBG1739 by TMHMM2.0 at aa 4-22, 43-62, 72-89 and 102-124 218493009389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493009390 S-adenosylmethionine binding site [chemical binding]; other site 218493009392 Methyltransferase domain; Region: Methyltransf_23; pfam13489 218493009393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493009394 S-adenosylmethionine binding site [chemical binding]; other site 218493009396 copper homeostasis protein CutC; Provisional; Region: PRK11572 218493009398 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 218493009399 putative metal binding site [ion binding]; other site 218493009402 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 218493009403 arginyl-tRNA synthetase; Region: argS; TIGR00456 218493009404 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 218493009405 active site 218493009406 HIGH motif; other site 218493009407 KMSK motif region; other site 218493009408 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 218493009409 tRNA binding surface [nucleotide binding]; other site 218493009410 anticodon binding site; other site 218493009415 penicillin-binding protein 2; Provisional; Region: PRK10795 218493009416 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218493009417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218493009418 1 probable transmembrane helix predicted for SBG1745 by TMHMM2.0 at aa 12-34 218493009421 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 218493009423 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218493009424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493009425 12 probable transmembrane helices predicted for SBG1747 by TMHMM2.0 at aa 13-35, 45-67, 86-103,108-130, 151-173, 178-200, 250-272, 287-309, 316-335,339-361, 397-414 and 424-446 218493009429 signal peptide predicted for SBG1748 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.945 between residues 16 and 17 218493009430 Flagellar protein FlhE; Region: FlhE; pfam06366 218493009432 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 218493009433 FHIPEP family; Region: FHIPEP; pfam00771 218493009435 7 probable transmembrane helices predicted for SBG1749 by TMHMM2.0 at aa 21-43, 47-64, 76-98, 118-140,209-231, 251-273 and 293-315 218493009437 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 218493009438 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 218493009440 4 probable transmembrane helices predicted for SBG1750 by TMHMM2.0 at aa 33-50, 93-115, 146-168 and 189-211 218493009442 chemotaxis regulator CheZ; Provisional; Region: PRK11166 218493009444 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 218493009445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493009446 active site 218493009447 phosphorylation site [posttranslational modification] 218493009448 intermolecular recognition site; other site 218493009449 dimerization interface [polypeptide binding]; other site 218493009451 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 218493009452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493009453 active site 218493009454 phosphorylation site [posttranslational modification] 218493009455 intermolecular recognition site; other site 218493009456 dimerization interface [polypeptide binding]; other site 218493009457 CheB methylesterase; Region: CheB_methylest; pfam01339 218493009460 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 218493009461 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 218493009462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493009463 S-adenosylmethionine binding site [chemical binding]; other site 218493009466 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 218493009467 signal peptide predicted for SBG1755 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.278 between residues 19 and 20 218493009468 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218493009469 dimer interface [polypeptide binding]; other site 218493009470 ligand binding site [chemical binding]; other site 218493009471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493009472 dimerization interface [polypeptide binding]; other site 218493009473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493009474 dimer interface [polypeptide binding]; other site 218493009475 putative CheW interface [polypeptide binding]; other site 218493009479 2 probable transmembrane helices predicted for SBG1755 by TMHMM2.0 at aa 10-32 and 194-212 218493009481 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 218493009482 putative CheA interaction surface; other site 218493009484 chemotaxis protein CheA; Provisional; Region: PRK10547 218493009485 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218493009486 putative binding surface; other site 218493009487 active site 218493009488 CheY binding; Region: CheY-binding; pfam09078 218493009489 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 218493009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493009491 ATP binding site [chemical binding]; other site 218493009492 Mg2+ binding site [ion binding]; other site 218493009493 G-X-G motif; other site 218493009494 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 218493009501 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 218493009502 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 218493009503 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218493009504 ligand binding site [chemical binding]; other site 218493009506 1 probable transmembrane helix predicted for SBG1758 by TMHMM2.0 at aa 29-51 218493009507 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 218493009508 flagellar motor protein MotA; Validated; Region: PRK09110 218493009509 4 probable transmembrane helices predicted for SBG1759 by TMHMM2.0 at aa 16-38, 43-65, 187-206 and 221-243 218493009512 transcriptional activator FlhC; Provisional; Region: PRK12722 218493009515 transcriptional activator FlhD; Provisional; Region: PRK02909 218493009517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493009518 Ligand Binding Site [chemical binding]; other site 218493009520 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 218493009521 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 218493009522 active site 218493009523 homotetramer interface [polypeptide binding]; other site 218493009525 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 218493009526 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 218493009528 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218493009529 TM-ABC transporter signature motif; other site 218493009530 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218493009531 4 probable transmembrane helices predicted for SBG1765 by TMHMM2.0 at aa 7-29, 39-58, 65-82 and 87-106 218493009533 DJ-1 family protein; Region: not_thiJ; TIGR01383 218493009534 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 218493009535 conserved cys residue [active] 218493009537 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 218493009538 Ferritin-like domain; Region: Ferritin; pfam00210 218493009539 ferroxidase diiron center [ion binding]; other site 218493009541 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 218493009542 signal peptide predicted for SBG1769 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.582 between residues 24 and 25 218493009543 YecR-like lipoprotein; Region: YecR; pfam13992 218493009545 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 218493009546 Ferritin-like domain; Region: Ferritin; pfam00210 218493009547 ferroxidase diiron center [ion binding]; other site 218493009549 probable metal-binding protein; Region: matur_matur; TIGR03853 218493009550 tyrosine transporter TyrP; Provisional; Region: PRK15132 218493009551 signal peptide predicted for SBG1772 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.601 between residues 28 and 29 218493009552 aromatic amino acid transport protein; Region: araaP; TIGR00837 218493009554 11 probable transmembrane helices predicted for SBG1772 by TMHMM2.0 at aa 7-29, 33-55, 81-103,113-135, 148-167, 182-204, 216-235, 273-295, 308-330,335-357 and 377-399 218493009556 hypothetical protein; Provisional; Region: PRK10396 218493009557 yecA family protein; Region: ygfB_yecA; TIGR02292 218493009558 SEC-C motif; Region: SEC-C; pfam02810 218493009561 signal peptide predicted for SBG1774 by SignalP 2.0 HMM (Signal peptide probabilty 0.870) with cleavage site probability 0.404 between residues 24 and 25 218493009562 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 218493009563 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 218493009564 NlpC/P60 family; Region: NLPC_P60; cl17555 218493009565 2 probable transmembrane helices predicted for SBG1775 by TMHMM2.0 at aa 10-32 and 78-100 218493009566 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 218493009567 signal peptide predicted for SBG1776 by SignalP 2.0 HMM (Signal peptide probabilty 0.666) with cleavage site probability 0.360 between residues 36 and 37 218493009569 4 probable transmembrane helices predicted for SBG1776 by TMHMM2.0 at aa 7-29, 33-52, 121-143 and 147-169 218493009571 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 218493009572 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 218493009573 GIY-YIG motif/motif A; other site 218493009574 active site 218493009575 catalytic site [active] 218493009576 putative DNA binding site [nucleotide binding]; other site 218493009577 metal binding site [ion binding]; metal-binding site 218493009578 UvrB/uvrC motif; Region: UVR; pfam02151 218493009579 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 218493009580 Helix-hairpin-helix motif; Region: HHH; pfam00633 218493009586 response regulator; Provisional; Region: PRK09483 218493009587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493009588 active site 218493009589 phosphorylation site [posttranslational modification] 218493009590 intermolecular recognition site; other site 218493009591 dimerization interface [polypeptide binding]; other site 218493009592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493009593 DNA binding residues [nucleotide binding] 218493009594 dimerization interface [polypeptide binding]; other site 218493009598 hypothetical protein; Provisional; Region: PRK10613 218493009599 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 218493009600 Autoinducer binding domain; Region: Autoind_bind; pfam03472 218493009601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493009602 DNA binding residues [nucleotide binding] 218493009603 dimerization interface [polypeptide binding]; other site 218493009607 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 218493009608 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218493009609 Walker A/P-loop; other site 218493009610 ATP binding site [chemical binding]; other site 218493009611 Q-loop/lid; other site 218493009612 ABC transporter signature motif; other site 218493009613 Walker B; other site 218493009614 D-loop; other site 218493009615 H-loop/switch region; other site 218493009616 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218493009621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493009622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493009623 dimer interface [polypeptide binding]; other site 218493009624 conserved gate region; other site 218493009625 putative PBP binding loops; other site 218493009626 ABC-ATPase subunit interface; other site 218493009628 3 probable transmembrane helices predicted for SBG1782 by TMHMM2.0 at aa 20-42, 54-76 and 185-207 218493009630 D-cysteine desulfhydrase; Validated; Region: PRK03910 218493009631 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 218493009632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493009633 catalytic residue [active] 218493009635 cystine transporter subunit; Provisional; Region: PRK11260 218493009636 signal peptide predicted for SBG1784 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.995 between residues 29 and 30 218493009637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493009638 substrate binding pocket [chemical binding]; other site 218493009639 membrane-bound complex binding site; other site 218493009640 hinge residues; other site 218493009643 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 218493009646 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 218493009647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218493009648 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218493009649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218493009650 DNA binding residues [nucleotide binding] 218493009656 flagellin; Validated; Region: PRK08026 218493009657 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 218493009658 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 218493009659 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 218493009663 flagellar capping protein; Reviewed; Region: fliD; PRK08032 218493009664 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 218493009665 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 218493009669 flagellar protein FliS; Validated; Region: fliS; PRK05685 218493009671 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 218493009673 lipoprotein; Provisional; Region: PRK10397 218493009674 signal peptide predicted for SBG1792 by SignalP 2.0 HMM (Signal peptide probabilty 0.940) with cleavage site probability 0.648 between residues 19 and 20 218493009676 signal peptide predicted for SBG1793 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.509 between residues 40 and 41 218493009677 putative inner membrane protein; Provisional; Region: PRK11099 218493009678 10 probable transmembrane helices predicted for SBG1793 by TMHMM2.0 at aa 21-43, 81-103, 116-138,148-170, 197-214, 224-246, 258-280, 284-306, 319-341 and 361-383 218493009683 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 218493009684 CPxP motif; other site 218493009687 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 218493009689 signal peptide predicted for SBG1798 by SignalP 2.0 HMM (Signal peptide probabilty 0.816) with cleavage site probability 0.811 between residues 46 and 47 218493009690 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 218493009691 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 218493009692 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 218493009694 1 probable transmembrane helix predicted for SBG1798 by TMHMM2.0 at aa 26-45 218493009696 flagellar motor switch protein FliG; Region: fliG; TIGR00207 218493009697 FliG C-terminal domain; Region: FliG_C; pfam01706 218493009699 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 218493009700 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 218493009701 Walker A motif/ATP binding site; other site 218493009702 Walker B motif; other site 218493009706 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 218493009707 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 218493009709 flagellar hook-length control protein; Provisional; Region: PRK10118 218493009710 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 218493009712 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 218493009713 signal peptide predicted for SBG1803 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.385 between residues 30 and 31 218493009715 1 probable transmembrane helix predicted for SBG1803 by TMHMM2.0 at aa 13-35 218493009717 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 218493009718 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 218493009720 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 218493009721 flagellar motor switch protein; Validated; Region: fliN; PRK05698 218493009723 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 218493009724 1 probable transmembrane helix predicted for SBG1806 by TMHMM2.0 at aa 17-39 218493009726 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 218493009727 signal peptide predicted for SBG1807 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.511 between residues 20 and 21 218493009728 5 probable transmembrane helices predicted for SBG1807 by TMHMM2.0 at aa 5-27, 47-69, 88-105, 185-207 and 214-236 218493009732 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 218493009733 signal peptide predicted for SBG1808 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.970 between residues 40 and 41 218493009735 2 probable transmembrane helices predicted for SBG1808 by TMHMM2.0 at aa 20-42 and 52-74 218493009736 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 218493009738 6 probable transmembrane helices predicted for SBG1809 by TMHMM2.0 at aa 15-34, 41-58, 73-95, 132-154,179-201 and 214-236 218493009739 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 218493009740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493009741 DNA binding residues [nucleotide binding] 218493009742 dimerization interface [polypeptide binding]; other site 218493009745 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 218493009746 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 218493009747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493009748 active site 218493009749 motif I; other site 218493009750 motif II; other site 218493009753 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 218493009754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493009755 metal binding site [ion binding]; metal-binding site 218493009756 active site 218493009757 I-site; other site 218493009759 2 probable transmembrane helices predicted for SBG1813 by TMHMM2.0 at aa 20-42 and 356-378 218493009760 Uncharacterized small protein [Function unknown]; Region: COG5475 218493009761 hypothetical protein; Provisional; Region: PRK10062 218493009763 6 probable transmembrane helices predicted for SBG1815 by TMHMM2.0 at aa 105-127, 131-153, 200-219,223-245, 280-302 and 317-339 218493009764 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 218493009765 EamA-like transporter family; Region: EamA; pfam00892 218493009766 EamA-like transporter family; Region: EamA; pfam00892 218493009767 10 probable transmembrane helices predicted for SBG1816 by TMHMM2.0 at aa 7-29, 39-57, 69-87, 97-119,126-145, 149-168, 175-197, 212-234, 241-260 and 270-292 218493009770 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 218493009771 additional DNA contacts [nucleotide binding]; other site 218493009772 mismatch recognition site; other site 218493009773 active site 218493009774 zinc binding site [ion binding]; other site 218493009775 DNA intercalation site [nucleotide binding]; other site 218493009777 DNA cytosine methylase; Provisional; Region: PRK10458 218493009778 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 218493009779 cofactor binding site; other site 218493009780 DNA binding site [nucleotide binding] 218493009781 substrate interaction site [chemical binding]; other site 218493009785 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 218493009786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218493009787 Zn2+ binding site [ion binding]; other site 218493009788 Mg2+ binding site [ion binding]; other site 218493009790 signal peptide predicted for SBG1820 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493009791 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493009792 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493009793 trimer interface [polypeptide binding]; other site 218493009794 eyelet of channel; other site 218493009797 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009798 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009799 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009800 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009801 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009802 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 218493009803 this CDS lacks a 5' region and has multiple frameshifts 218493009805 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 218493009808 this CDS appears to have been subject to a deletion removing the 3'region 218493009809 1 probable transmembrane helix predicted for SBG1828 by TMHMM2.0 at aa 86-108 218493009810 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493009811 signal peptide predicted for SBG1830 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.584 between residues 23 and 24 218493009812 Peptidase family C69; Region: Peptidase_C69; cl17793 218493009813 1 probable transmembrane helix predicted for SBG1830 by TMHMM2.0 at aa 7-29 218493009816 1 probable transmembrane helix predicted for SBG1832 by TMHMM2.0 at aa 77-99 218493009817 signal peptide predicted for SBG1832 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.958 between residues 60 and 61 218493009818 signal peptide predicted for SBG1834 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 26 and 27 218493009819 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 218493009820 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 218493009821 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218493009824 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 218493009825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493009828 this CDS appears to have been subject to a deletion event removing the 3' end 218493009829 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 218493009830 VRR-NUC domain; Region: VRR_NUC; cl17748 218493009831 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493009832 AMP nucleosidase; Provisional; Region: PRK08292 218493009833 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 218493009834 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 218493009836 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218493009838 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 218493009839 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 218493009840 RHS Repeat; Region: RHS_repeat; pfam05593 218493009841 RHS Repeat; Region: RHS_repeat; cl11982 218493009842 RHS Repeat; Region: RHS_repeat; pfam05593 218493009843 RHS Repeat; Region: RHS_repeat; pfam05593 218493009844 RHS Repeat; Region: RHS_repeat; cl11982 218493009845 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218493009846 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 218493009858 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 218493009859 MATE family multidrug exporter; Provisional; Region: PRK10189 218493009860 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 218493009861 12 probable transmembrane helices predicted for SBG1849 by TMHMM2.0 at aa 72-94, 109-131, 144-163,183-205, 217-239, 254-276, 289-309, 319-341, 375-397,412-431, 443-465 and 469-491 218493009864 integrase; Provisional; Region: PRK09692 218493009865 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218493009866 active site 218493009867 Int/Topo IB signature motif; other site 218493009869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493009870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493009871 DNA binding residues [nucleotide binding] 218493009872 dimerization interface [polypeptide binding]; other site 218493009874 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218493009875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493009876 putative substrate translocation pore; other site 218493009877 12 probable transmembrane helices predicted for SBG1852 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 96-118,130-152, 162-179, 200-222, 237-259, 266-285, 289-308,329-351 and 355-372 218493009879 signal peptide predicted for SBG1852 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.816 between residues 21 and 22 218493009881 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 218493009882 Integrase; Region: Integrase_1; pfam12835 218493009883 signal peptide predicted for SBG1856 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.557 between residues 34 and 35 218493009884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493009885 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 218493009886 putative substrate translocation pore; other site 218493009887 12 probable transmembrane helices predicted for SBG1856 by TMHMM2.0 at aa 13-35, 55-74, 81-103,107-129, 142-164, 169-191, 224-246, 256-273, 286-305,310-332, 345-367 and 377-395 218493009890 1 probable transmembrane helix predicted for SBG1857 by TMHMM2.0 at aa 33-55 218493009891 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 218493009892 NADH(P)-binding; Region: NAD_binding_10; pfam13460 218493009893 NAD(P) binding site [chemical binding]; other site 218493009894 putative active site [active] 218493009896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493009897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493009898 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218493009899 putative effector binding pocket; other site 218493009900 putative dimerization interface [polypeptide binding]; other site 218493009904 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493009905 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493009906 active site 218493009907 catalytic tetrad [active] 218493009909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493009910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493009911 active site 218493009912 catalytic tetrad [active] 218493009917 signal peptide predicted for SBG1862 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.951 between residues 20 and 21 218493009918 Protein of unknown function, DUF606; Region: DUF606; pfam04657 218493009919 5 probable transmembrane helices predicted for SBG1862 by TMHMM2.0 at aa 4-26, 31-53, 68-87, 94-116 and 121-143 218493009921 signal peptide predicted for SBG1863 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.763 between residues 42 and 43 218493009922 Protein of unknown function, DUF606; Region: DUF606; pfam04657 218493009923 5 probable transmembrane helices predicted for SBG1863 by TMHMM2.0 at aa 21-40, 55-77, 84-106, 110-132 and 145-164 218493009925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493009926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493009927 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218493009928 putative effector binding pocket; other site 218493009929 dimerization interface [polypeptide binding]; other site 218493009932 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 218493009933 8 probable transmembrane helices predicted for SBG1865 by TMHMM2.0 at aa 21-43, 58-80, 101-123, 143-165,177-199, 219-240, 280-302 and 322-341 218493009936 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218493009937 active site 218493009938 P-loop; other site 218493009939 phosphorylation site [posttranslational modification] 218493009941 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493009942 active site 218493009943 phosphorylation site [posttranslational modification] 218493009945 transketolase; Reviewed; Region: PRK12753 218493009946 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218493009947 TPP-binding site [chemical binding]; other site 218493009948 dimer interface [polypeptide binding]; other site 218493009949 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218493009950 PYR/PP interface [polypeptide binding]; other site 218493009951 dimer interface [polypeptide binding]; other site 218493009952 TPP binding site [chemical binding]; other site 218493009953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218493009959 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 218493009960 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218493009961 substrate binding site [chemical binding]; other site 218493009962 hexamer interface [polypeptide binding]; other site 218493009963 metal binding site [ion binding]; metal-binding site 218493009966 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 218493009967 11 probable transmembrane helices predicted for SBG1870 by TMHMM2.0 at aa 5-27, 40-62, 91-110,117-139, 143-165, 222-239, 254-276, 307-329, 339-361,368-390 and 400-419 218493009969 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218493009970 active site 218493009971 P-loop; other site 218493009972 phosphorylation site [posttranslational modification] 218493009974 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493009975 active site 218493009976 phosphorylation site [posttranslational modification] 218493009978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493009979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493009980 DNA binding site [nucleotide binding] 218493009981 domain linker motif; other site 218493009982 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 218493009986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493009987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493009988 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218493009989 putative effector binding pocket; other site 218493009990 dimerization interface [polypeptide binding]; other site 218493009994 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 218493009995 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 218493009996 dimer interface [polypeptide binding]; other site 218493009997 active site 218493009998 metal binding site [ion binding]; metal-binding site 218493010000 short chain dehydrogenase; Provisional; Region: PRK06940 218493010001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218493010002 NAD(P) binding site [chemical binding]; other site 218493010003 active site 218493010007 L,D-transpeptidase; Provisional; Region: PRK10190 218493010008 signal peptide predicted for SBG1881 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 21 and 22 218493010009 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218493010011 1 probable transmembrane helix predicted for SBG1881 by TMHMM2.0 at aa 5-27 218493010012 pseudo, deletion event 218493010015 1 probable transmembrane helix predicted for SBG1882 by TMHMM2.0 at aa 25-47 218493010016 this CDS has been subject to a deletion event removing the 5'region 218493010017 hypothetical protein; Provisional; Region: PRK05423 218493010019 Predicted membrane protein [Function unknown]; Region: COG1289 218493010020 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218493010021 6 probable transmembrane helices predicted for SBG1884 by TMHMM2.0 at aa 20-42, 47-66, 73-92, 96-113,118-135 and 140-162 218493010022 DNA gyrase inhibitor; Provisional; Region: PRK10016 218493010024 signal peptide predicted for SBG1886 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 23 and 24 218493010025 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 218493010026 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218493010027 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 218493010030 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 218493010031 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 218493010033 5 probable transmembrane helices predicted for SBG1887 by TMHMM2.0 at aa 15-37, 66-88, 93-115, 169-191 and 201-223 218493010034 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 218493010035 4Fe-4S binding domain; Region: Fer4; cl02805 218493010039 thiosulfate reductase PhsA; Provisional; Region: PRK15488 218493010040 signal peptide predicted for SBG1889 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 30 and 31 218493010041 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 218493010042 putative [Fe4-S4] binding site [ion binding]; other site 218493010043 putative molybdopterin cofactor binding site [chemical binding]; other site 218493010044 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 218493010045 putative molybdopterin cofactor binding site; other site 218493010052 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 218493010054 Transposase; Region: HTH_Tnp_1; pfam01527 218493010056 putative transposase OrfB; Reviewed; Region: PHA02517 218493010057 HTH-like domain; Region: HTH_21; pfam13276 218493010058 Integrase core domain; Region: rve; pfam00665 218493010059 Integrase core domain; Region: rve_3; pfam13683 218493010062 exonuclease I; Provisional; Region: sbcB; PRK11779 218493010063 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 218493010064 active site 218493010065 catalytic site [active] 218493010066 substrate binding site [chemical binding]; other site 218493010067 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 218493010070 signal peptide predicted for SBG1895 by SignalP 2.0 HMM (Signal peptide probabilty 0.736) with cleavage site probability 0.589 between residues 33 and 34 218493010071 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 218493010072 12 probable transmembrane helices predicted for SBG1895 by TMHMM2.0 at aa 20-38, 53-75, 96-118,133-151, 158-180, 200-219, 240-262, 289-311, 342-364,368-385, 398-417 and 422-439 218493010074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493010075 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 218493010076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493010077 dimerization interface [polypeptide binding]; other site 218493010080 signal peptide predicted for SBG1897 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.289 between residues 24 and 25 218493010081 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218493010082 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 218493010083 putative NAD(P) binding site [chemical binding]; other site 218493010086 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 218493010087 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 218493010088 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 218493010092 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 218493010093 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 218493010094 NAD binding site [chemical binding]; other site 218493010095 dimerization interface [polypeptide binding]; other site 218493010096 product binding site; other site 218493010097 substrate binding site [chemical binding]; other site 218493010098 zinc binding site [ion binding]; other site 218493010099 catalytic residues [active] 218493010102 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 218493010103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493010104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493010105 homodimer interface [polypeptide binding]; other site 218493010106 catalytic residue [active] 218493010109 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 218493010110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493010111 active site 218493010112 motif I; other site 218493010113 motif II; other site 218493010114 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 218493010115 putative active site pocket [active] 218493010116 4-fold oligomerization interface [polypeptide binding]; other site 218493010117 metal binding residues [ion binding]; metal-binding site 218493010118 3-fold/trimer interface [polypeptide binding]; other site 218493010123 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 218493010124 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 218493010125 putative active site [active] 218493010126 oxyanion strand; other site 218493010127 catalytic triad [active] 218493010130 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 218493010131 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 218493010132 catalytic residues [active] 218493010134 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 218493010135 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 218493010136 substrate binding site [chemical binding]; other site 218493010137 glutamase interaction surface [polypeptide binding]; other site 218493010139 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 218493010140 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 218493010141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 218493010142 metal binding site [ion binding]; metal-binding site 218493010146 chain length determinant protein WzzB; Provisional; Region: PRK15471 218493010147 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 218493010148 2 probable transmembrane helices predicted for SBG1906 by TMHMM2.0 at aa 32-51 and 296-315 218493010150 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 218493010151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 218493010152 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 218493010153 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 218493010157 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218493010158 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 218493010159 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 218493010163 S. bongori-specific LPS core region, note low G+C 218493010164 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 218493010165 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 218493010166 NAD binding site [chemical binding]; other site 218493010167 homodimer interface [polypeptide binding]; other site 218493010168 active site 218493010169 substrate binding site [chemical binding]; other site 218493010171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493010172 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218493010174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493010175 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218493010177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493010178 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 218493010179 putative ADP-binding pocket [chemical binding]; other site 218493010181 1 probable transmembrane helix predicted for SBG1913 by TMHMM2.0 at aa 12-34 218493010182 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218493010183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218493010184 active site 218493010186 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 218493010187 12 probable transmembrane helices predicted for SBG1915 by TMHMM2.0 at aa 20-42, 52-71, 92-114,118-140, 153-175, 180-199, 212-234, 249-271, 292-314,327-349, 362-384 and 389-408 218493010189 signal peptide predicted for SBG1916 by SignalP 2.0 HMM (Signal peptide probabilty 0.712) with cleavage site probability 0.676 between residues 22 and 23 218493010190 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 218493010191 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 218493010192 active site 218493010193 tetramer interface; other site 218493010195 insertion wrt to St CT18 218493010196 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 218493010197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218493010198 putative NAD(P) binding site [chemical binding]; other site 218493010199 active site 218493010200 putative substrate binding site [chemical binding]; other site 218493010202 signal peptide predicted for SBG1918 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 31 and 32 218493010203 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 218493010204 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 218493010205 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 218493010206 putative ADP-binding pocket [chemical binding]; other site 218493010208 colanic acid biosynthesis protein; Provisional; Region: PRK10017 218493010209 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 218493010211 colanic acid exporter; Provisional; Region: PRK10459 218493010212 signal peptide predicted for SBG1921 by SignalP 2.0 HMM (Signal peptide probabilty 0.825) with cleavage site probability 0.712 between residues 33 and 34 218493010213 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 218493010214 10 probable transmembrane helices predicted for SBG1921 by TMHMM2.0 at aa 13-35, 45-67, 80-102,165-187, 286-308, 323-340, 361-383, 387-409, 416-438 and 448-467 218493010216 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 218493010217 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 218493010219 5 probable transmembrane helices predicted for SBG1922 by TMHMM2.0 at aa 13-35, 45-64, 84-101, 111-130 and 279-300 218493010220 phosphomannomutase CpsG; Provisional; Region: PRK15414 218493010221 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 218493010222 active site 218493010223 substrate binding site [chemical binding]; other site 218493010224 metal binding site [ion binding]; metal-binding site 218493010230 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 218493010231 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 218493010232 Substrate binding site; other site 218493010233 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 218493010236 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 218493010237 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 218493010239 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 218493010240 active site 218493010241 GDP-Mannose binding site [chemical binding]; other site 218493010242 dimer interface [polypeptide binding]; other site 218493010243 modified nudix motif 218493010244 metal binding site [ion binding]; metal-binding site 218493010246 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 218493010247 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 218493010248 NADP binding site [chemical binding]; other site 218493010249 active site 218493010250 putative substrate binding site [chemical binding]; other site 218493010252 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 218493010253 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 218493010254 NADP-binding site; other site 218493010255 homotetramer interface [polypeptide binding]; other site 218493010256 substrate binding site [chemical binding]; other site 218493010257 homodimer interface [polypeptide binding]; other site 218493010258 active site 218493010261 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 218493010262 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 218493010263 putative trimer interface [polypeptide binding]; other site 218493010264 putative active site [active] 218493010265 putative substrate binding site [chemical binding]; other site 218493010266 putative CoA binding site [chemical binding]; other site 218493010271 putative glycosyl transferase; Provisional; Region: PRK10063 218493010272 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 218493010273 metal-binding site 218493010275 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 218493010276 12 probable transmembrane helices predicted for SBG1931 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103,116-138, 148-165, 172-189, 204-226, 246-268, 283-305,326-348 and 368-390 218493010277 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218493010278 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 218493010279 putative acyl transferase; Provisional; Region: PRK10191 218493010280 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 218493010281 trimer interface [polypeptide binding]; other site 218493010282 active site 218493010283 substrate binding site [chemical binding]; other site 218493010284 CoA binding site [chemical binding]; other site 218493010289 putative glycosyl transferase; Provisional; Region: PRK10018 218493010290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218493010291 active site 218493010293 tyrosine kinase; Provisional; Region: PRK11519 218493010294 Chain length determinant protein; Region: Wzz; pfam02706 218493010295 Chain length determinant protein; Region: Wzz; cl15801 218493010296 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 218493010297 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218493010298 2 probable transmembrane helices predicted for SBG1935 by TMHMM2.0 at aa 30-52 and 425-447 218493010300 Low molecular weight phosphatase family; Region: LMWPc; cd00115 218493010301 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 218493010302 active site 218493010304 signal peptide predicted for SBG1937 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.611 between residues 33 and 34 218493010305 polysaccharide export protein Wza; Provisional; Region: PRK15078 218493010306 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 218493010307 SLBB domain; Region: SLBB; pfam10531 218493010310 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218493010311 FOG: CBS domain [General function prediction only]; Region: COG0517 218493010312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218493010313 Transporter associated domain; Region: CorC_HlyC; smart01091 218493010315 7 probable transmembrane helices predicted for SBG1938 by TMHMM2.0 at aa 13-35, 48-70, 80-99, 126-148,153-172, 185-207 and 212-234 218493010318 putative assembly protein; Provisional; Region: PRK10833 218493010319 signal peptide predicted for SBG1939 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.320 between residues 26 and 27 218493010320 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218493010322 1 probable transmembrane helix predicted for SBG1939 by TMHMM2.0 at aa 7-26 218493010323 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218493010324 trimer interface [polypeptide binding]; other site 218493010325 active site 218493010327 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 218493010328 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 218493010329 ATP-binding site [chemical binding]; other site 218493010330 Sugar specificity; other site 218493010331 Pyrimidine base specificity; other site 218493010334 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 218493010335 signal peptide predicted for SBG1942 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.243 between residues 61 and 62 218493010336 PAS domain S-box; Region: sensory_box; TIGR00229 218493010337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493010338 putative active site [active] 218493010339 heme pocket [chemical binding]; other site 218493010340 PAS domain S-box; Region: sensory_box; TIGR00229 218493010341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493010342 putative active site [active] 218493010343 heme pocket [chemical binding]; other site 218493010344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218493010345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493010346 metal binding site [ion binding]; metal-binding site 218493010347 active site 218493010348 I-site; other site 218493010349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493010350 10 probable transmembrane helices predicted for SBG1942 by TMHMM2.0 at aa 15-37, 64-86, 90-112,124-146, 156-177, 190-207, 212-229, 236-258, 268-290 and 310-327 218493010356 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 218493010357 AlkA N-terminal domain; Region: AlkA_N; pfam06029 218493010358 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218493010359 minor groove reading motif; other site 218493010360 helix-hairpin-helix signature motif; other site 218493010361 substrate binding pocket [chemical binding]; other site 218493010362 active site 218493010366 putative chaperone; Provisional; Region: PRK11678 218493010367 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 218493010368 nucleotide binding site [chemical binding]; other site 218493010369 putative NEF/HSP70 interaction site [polypeptide binding]; other site 218493010370 SBD interface [polypeptide binding]; other site 218493010372 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 218493010373 signal peptide predicted for SBG1946 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.622 between residues 39 and 40 218493010374 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493010375 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493010376 1 probable transmembrane helix predicted for SBG1946 by TMHMM2.0 at aa 7-26 218493010378 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 218493010379 Protein export membrane protein; Region: SecD_SecF; cl14618 218493010381 11 probable transmembrane helices predicted for SBG1947 by TMHMM2.0 at aa 15-37, 345-362, 367-389,396-418, 438-460, 472-494, 535-557, 867-889, 909-931,968-990 and 1000-1022 218493010382 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 218493010384 10 probable transmembrane helices predicted for SBG1948 by TMHMM2.0 at aa 7-29, 336-353, 360-382,434-456, 463-485, 525-547, 853-875, 895-917, 949-971 and 986-1008 218493010385 putative transporter; Provisional; Region: PRK10504 218493010386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010387 putative substrate translocation pore; other site 218493010388 13 probable transmembrane helices predicted for SBG1949 by TMHMM2.0 at aa 12-34, 47-69, 76-98,102-124, 136-158, 163-185, 197-214, 224-243, 250-272,287-309, 329-351, 395-417 and 430-452 218493010390 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 218493010391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493010392 dimerization interface [polypeptide binding]; other site 218493010393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493010394 dimer interface [polypeptide binding]; other site 218493010395 phosphorylation site [posttranslational modification] 218493010396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493010397 ATP binding site [chemical binding]; other site 218493010398 Mg2+ binding site [ion binding]; other site 218493010399 G-X-G motif; other site 218493010400 2 probable transmembrane helices predicted for SBG1950 by TMHMM2.0 at aa 13-35 and 168-190 218493010404 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 218493010405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493010406 active site 218493010407 phosphorylation site [posttranslational modification] 218493010408 intermolecular recognition site; other site 218493010409 dimerization interface [polypeptide binding]; other site 218493010410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493010411 DNA binding site [nucleotide binding] 218493010415 putative protease; Provisional; Region: PRK15452 218493010416 Peptidase family U32; Region: Peptidase_U32; pfam01136 218493010419 lipid kinase; Reviewed; Region: PRK13054 218493010420 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 218493010422 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 218493010423 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 218493010424 putative active site; other site 218493010425 catalytic residue [active] 218493010427 nucleoside transporter; Region: 2A0110; TIGR00889 218493010428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010429 putative substrate translocation pore; other site 218493010431 12 probable transmembrane helices predicted for SBG1955 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119,132-154, 159-181, 210-232, 247-266, 273-292, 302-324,336-358 and 378-400 218493010433 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 218493010435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493010436 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 218493010437 substrate binding site [chemical binding]; other site 218493010438 ATP binding site [chemical binding]; other site 218493010442 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218493010443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493010444 DNA-binding site [nucleotide binding]; DNA binding site 218493010445 UTRA domain; Region: UTRA; pfam07702 218493010448 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 218493010449 dimer interface [polypeptide binding]; other site 218493010450 substrate binding site [chemical binding]; other site 218493010451 ATP binding site [chemical binding]; other site 218493010453 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 218493010454 substrate binding site [chemical binding]; other site 218493010455 multimerization interface [polypeptide binding]; other site 218493010456 ATP binding site [chemical binding]; other site 218493010459 Predicted integral membrane protein [Function unknown]; Region: COG5455 218493010460 signal peptide predicted for SBG1961 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 19 and 20 218493010461 stc fimbrial operon 218493010462 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 218493010463 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 218493010464 signal peptide predicted for SBG1962 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.668 between residues 22 and 23 218493010465 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 218493010466 signal peptide predicted for SBG1963 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493010467 PapC N-terminal domain; Region: PapC_N; pfam13954 218493010468 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493010469 PapC C-terminal domain; Region: PapC_C; pfam13953 218493010471 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 218493010472 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493010476 fimbrial chaperone protein; Provisional; Region: PRK15220 218493010477 signal peptide predicted for SBG1965 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493010480 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 218493010481 signal peptide predicted for SBG1966 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.988 between residues 22 and 23 218493010482 antiporter inner membrane protein; Provisional; Region: PRK11670 218493010483 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 218493010484 Walker A motif; other site 218493010487 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 218493010488 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 218493010489 active site 218493010490 HIGH motif; other site 218493010491 KMSKS motif; other site 218493010492 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 218493010493 tRNA binding surface [nucleotide binding]; other site 218493010494 anticodon binding site; other site 218493010495 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 218493010496 dimer interface [polypeptide binding]; other site 218493010497 putative tRNA-binding site [nucleotide binding]; other site 218493010501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 218493010502 signal peptide predicted for SBG1969 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.353 between residues 22 and 23 218493010505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 218493010506 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 218493010507 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 218493010510 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 218493010511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493010512 active site 218493010513 phosphorylation site [posttranslational modification] 218493010514 intermolecular recognition site; other site 218493010515 dimerization interface [polypeptide binding]; other site 218493010516 LytTr DNA-binding domain; Region: LytTR; pfam04397 218493010519 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 218493010520 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 218493010521 GAF domain; Region: GAF; pfam01590 218493010522 Histidine kinase; Region: His_kinase; pfam06580 218493010523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493010524 ATP binding site [chemical binding]; other site 218493010525 Mg2+ binding site [ion binding]; other site 218493010526 G-X-G motif; other site 218493010530 6 probable transmembrane helices predicted for SBG1972 by TMHMM2.0 at aa 4-23, 44-63, 73-95, 107-129,139-161 and 168-190 218493010533 transcriptional regulator MirA; Provisional; Region: PRK15043 218493010534 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 218493010535 DNA binding residues [nucleotide binding] 218493010538 hypothetical protein; Provisional; Region: PRK13681 218493010539 signal peptide predicted for SBG1974 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.732 between residues 25 and 26 218493010540 1 probable transmembrane helix predicted for SBG1974 by TMHMM2.0 at aa 7-29 218493010541 signal peptide predicted for SBG1975 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.961 between residues 30 and 31 218493010542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493010543 putative PBP binding loops; other site 218493010544 ABC-ATPase subunit interface; other site 218493010546 6 probable transmembrane helices predicted for SBG1975 by TMHMM2.0 at aa 7-29, 51-73, 86-108, 118-140,180-202 and 212-231 218493010548 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 218493010549 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 218493010550 Walker A/P-loop; other site 218493010551 ATP binding site [chemical binding]; other site 218493010552 Q-loop/lid; other site 218493010553 ABC transporter signature motif; other site 218493010554 Walker B; other site 218493010555 D-loop; other site 218493010556 H-loop/switch region; other site 218493010557 CBS domain; Region: CBS; pfam00571 218493010561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493010562 dimer interface [polypeptide binding]; other site 218493010563 conserved gate region; other site 218493010564 ABC-ATPase subunit interface; other site 218493010566 7 probable transmembrane helices predicted for SBG1977 by TMHMM2.0 at aa 20-39, 88-107, 133-155, 162-184,199-221, 274-296 and 306-328 218493010569 signal peptide predicted for SBG1978 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493010570 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 218493010572 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 218493010573 signal peptide predicted for SBG1979 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 20 and 21 218493010574 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 218493010575 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 218493010579 D-lactate dehydrogenase; Provisional; Region: PRK11183 218493010580 FAD binding domain; Region: FAD_binding_4; pfam01565 218493010581 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 218493010585 signal peptide predicted for SBG1981 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.965 between residues 25 and 26 218493010586 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 218493010587 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 218493010589 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 218493010591 5 probable transmembrane helices predicted for SBG1982 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192 218493010592 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218493010593 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 218493010594 5 probable transmembrane helices predicted for SBG1983 by TMHMM2.0 at aa 21-43, 53-75, 100-122, 137-159 and 172-189 218493010596 oxidoreductase; Provisional; Region: PRK12743 218493010597 classical (c) SDRs; Region: SDR_c; cd05233 218493010598 NAD(P) binding site [chemical binding]; other site 218493010599 active site 218493010602 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 218493010603 signal peptide predicted for SBG1985 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.710 between residues 33 and 34 218493010607 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 218493010608 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218493010609 FMN binding site [chemical binding]; other site 218493010610 active site 218493010611 catalytic residues [active] 218493010612 substrate binding site [chemical binding]; other site 218493010616 signal peptide predicted for SBG1987 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.632 between residues 20 and 21 218493010617 salicylate hydroxylase; Provisional; Region: PRK08163 218493010618 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 218493010620 1 probable transmembrane helix predicted for SBG1987 by TMHMM2.0 at aa 7-24 218493010621 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 218493010622 maleylacetoacetate isomerase; Region: maiA; TIGR01262 218493010623 C-terminal domain interface [polypeptide binding]; other site 218493010624 GSH binding site (G-site) [chemical binding]; other site 218493010625 putative dimer interface [polypeptide binding]; other site 218493010626 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 218493010627 dimer interface [polypeptide binding]; other site 218493010628 N-terminal domain interface [polypeptide binding]; other site 218493010629 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 218493010631 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 218493010632 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 218493010634 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 218493010635 Cupin domain; Region: Cupin_2; pfam07883 218493010636 Cupin domain; Region: Cupin_2; pfam07883 218493010639 benzoate transport; Region: 2A0115; TIGR00895 218493010640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010641 putative substrate translocation pore; other site 218493010642 10 probable transmembrane helices predicted for SBG1991 by TMHMM2.0 at aa 21-43, 58-80, 148-170,175-197, 253-275, 290-312, 319-338, 342-364, 385-407 and 412-434 218493010644 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 218493010645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493010646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493010647 dimerization interface [polypeptide binding]; other site 218493010651 hypothetical protein; Provisional; Region: PRK01821 218493010652 signal peptide predicted for SBG1993 by SignalP 2.0 HMM (Signal peptide probabilty 0.746) with cleavage site probability 0.584 between residues 29 and 30 218493010653 4 probable transmembrane helices predicted for SBG1993 by TMHMM2.0 at aa 7-29, 34-56, 63-85 and 95-117 218493010655 hypothetical protein; Provisional; Region: PRK10711 218493010656 signal peptide predicted for SBG1994 by SignalP 2.0 HMM (Signal peptide probabilty 0.615) with cleavage site probability 0.430 between residues 23 and 24 218493010657 6 probable transmembrane helices predicted for SBG1994 by TMHMM2.0 at aa 4-23, 30-52, 90-112, 119-141,145-167 and 206-228 218493010659 cytidine deaminase; Provisional; Region: PRK09027 218493010660 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 218493010661 active site 218493010662 catalytic motif [active] 218493010663 Zn binding site [ion binding]; other site 218493010664 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 218493010665 active site 218493010666 catalytic motif [active] 218493010667 Zn binding site [ion binding]; other site 218493010672 signal peptide predicted for SBG1996 by SignalP 2.0 HMM (Signal peptide probabilty 0.957) with cleavage site probability 0.843 between residues 22 and 23 218493010673 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218493010674 putative active site [active] 218493010675 1 probable transmembrane helix predicted for SBG1996 by TMHMM2.0 at aa 5-27 218493010677 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 218493010678 2 probable transmembrane helices predicted for SBG1997 by TMHMM2.0 at aa 5-24 and 56-78 218493010679 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 218493010680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493010681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493010685 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 218493010686 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 218493010687 homodimer interface [polypeptide binding]; other site 218493010688 active site 218493010689 FMN binding site [chemical binding]; other site 218493010690 substrate binding site [chemical binding]; other site 218493010695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218493010696 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218493010697 TM-ABC transporter signature motif; other site 218493010698 9 probable transmembrane helices predicted for SBG2000 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149,179-201, 222-244, 259-281, 286-308 and 312-330 218493010700 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218493010701 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 218493010702 Walker A/P-loop; other site 218493010703 ATP binding site [chemical binding]; other site 218493010704 Q-loop/lid; other site 218493010705 ABC transporter signature motif; other site 218493010706 Walker B; other site 218493010707 D-loop; other site 218493010708 H-loop/switch region; other site 218493010709 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218493010714 signal peptide predicted for SBG2002 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.974 between residues 23 and 24 218493010715 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 218493010716 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 218493010717 ligand binding site [chemical binding]; other site 218493010718 calcium binding site [ion binding]; other site 218493010721 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 218493010722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493010723 DNA binding site [nucleotide binding] 218493010724 domain linker motif; other site 218493010725 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218493010726 dimerization interface (closed form) [polypeptide binding]; other site 218493010727 ligand binding site [chemical binding]; other site 218493010732 Predicted membrane protein [Function unknown]; Region: COG2311 218493010733 hypothetical protein; Provisional; Region: PRK10835 218493010735 10 probable transmembrane helices predicted for SBG2004 by TMHMM2.0 at aa 7-29, 55-77, 84-103,107-123, 130-152, 199-221, 234-253, 273-290, 310-332 and 337-359 218493010737 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 218493010738 GTP cyclohydrolase I; Provisional; Region: PLN03044 218493010739 active site 218493010743 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 218493010744 S-formylglutathione hydrolase; Region: PLN02442 218493010746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493010747 non-specific DNA binding site [nucleotide binding]; other site 218493010748 salt bridge; other site 218493010749 sequence-specific DNA binding site [nucleotide binding]; other site 218493010751 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 218493010752 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218493010753 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218493010756 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 218493010757 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218493010758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493010759 motif II; other site 218493010762 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 218493010763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010764 putative substrate translocation pore; other site 218493010765 10 probable transmembrane helices predicted for SBG2011 by TMHMM2.0 at aa 29-46, 69-91, 103-125,160-182, 189-208, 240-262, 323-345, 350-372, 385-407 and 412-434 218493010768 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 218493010769 signal peptide predicted for SBG2012 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.954 between residues 25 and 26 218493010770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493010771 N-terminal plug; other site 218493010772 ligand-binding site [chemical binding]; other site 218493010777 lysine transporter; Provisional; Region: PRK10836 218493010778 signal peptide predicted for SBG2013 by SignalP 2.0 HMM (Signal peptide probabilty 0.830) with cleavage site probability 0.681 between residues 46 and 47 218493010780 12 probable transmembrane helices predicted for SBG2013 by TMHMM2.0 at aa 21-43, 53-75, 103-125,130-152, 159-181, 196-218, 245-267, 287-309, 343-365,370-392, 413-435 and 445-467 218493010782 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 218493010783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493010784 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 218493010785 putative dimerization interface [polypeptide binding]; other site 218493010789 signal peptide predicted for SBG2015 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.557 between residues 40 and 41 218493010790 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 218493010791 10 probable transmembrane helices predicted for SBG2015 by TMHMM2.0 at aa 13-35, 39-61, 100-122,132-151, 164-186, 196-218, 225-247, 262-284, 291-313 and 323-345 218493010794 endonuclease IV; Provisional; Region: PRK01060 218493010795 signal peptide predicted for SBG2016 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.955 between residues 21 and 22 218493010796 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 218493010797 AP (apurinic/apyrimidinic) site pocket; other site 218493010798 DNA interaction; other site 218493010799 Metal-binding active site; metal-binding site 218493010804 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 218493010805 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 218493010806 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218493010807 active site 218493010808 P-loop; other site 218493010809 phosphorylation site [posttranslational modification] 218493010810 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 218493010811 9 probable transmembrane helices predicted for SBG2017 by TMHMM2.0 at aa 236-258, 271-293, 303-325,345-367, 377-399, 412-434, 464-481, 488-508 and 528-550 218493010814 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 218493010815 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 218493010816 putative substrate binding site [chemical binding]; other site 218493010817 putative ATP binding site [chemical binding]; other site 218493010822 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 218493010823 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493010824 active site 218493010825 phosphorylation site [posttranslational modification] 218493010826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218493010827 dimerization domain swap beta strand [polypeptide binding]; other site 218493010828 regulatory protein interface [polypeptide binding]; other site 218493010829 active site 218493010830 regulatory phosphorylation site [posttranslational modification]; other site 218493010836 sugar efflux transporter B; Provisional; Region: PRK15011 218493010837 signal peptide predicted for SBG2020 by SignalP 2.0 HMM (Signal peptide probabilty 0.876) with cleavage site probability 0.823 between residues 32 and 33 218493010838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010839 putative substrate translocation pore; other site 218493010840 12 probable transmembrane helices predicted for SBG2020 by TMHMM2.0 at aa 13-35, 50-72, 84-101,105-124, 145-167, 172-194, 222-244, 254-276, 283-302,306-328, 349-367 and 371-390 218493010843 Flagellin N-methylase; Region: FliB; cl00497 218493010845 elongation factor P; Provisional; Region: PRK04542 218493010846 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218493010847 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218493010848 RNA binding site [nucleotide binding]; other site 218493010849 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218493010850 RNA binding site [nucleotide binding]; other site 218493010855 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 218493010858 signal peptide predicted for SBG2024 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.608 between residues 27 and 28 218493010859 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 218493010860 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 218493010861 molybdopterin cofactor binding site [chemical binding]; other site 218493010862 substrate binding site [chemical binding]; other site 218493010863 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 218493010864 molybdopterin cofactor binding site; other site 218493010868 1 probable transmembrane helix predicted for SBG2024 by TMHMM2.0 at aa 13-32 218493010869 signal peptide predicted for SBG2025 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.340 between residues 25 and 26 218493010870 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 218493010871 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 218493010878 1 probable transmembrane helix predicted for SBG2025 by TMHMM2.0 at aa 7-29 218493010879 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218493010880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493010881 DNA-binding site [nucleotide binding]; DNA binding site 218493010882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493010883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493010884 homodimer interface [polypeptide binding]; other site 218493010885 catalytic residue [active] 218493010888 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 218493010889 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 218493010890 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 218493010894 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493010895 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 218493010896 active site 218493010897 5 probable transmembrane helices predicted for SBG2028 by TMHMM2.0 at aa 7-26, 64-83, 95-117, 162-184 and 191-213 218493010899 signal peptide predicted for SBG2029 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.545 between residues 33 and 34 218493010900 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 218493010901 NlpC/P60 family; Region: NLPC_P60; pfam00877 218493010904 phage resistance protein; Provisional; Region: PRK10551 218493010905 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218493010906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493010907 2 probable transmembrane helices predicted for SBG2030 by TMHMM2.0 at aa 12-34 and 236-258 218493010909 signal peptide predicted for SBG2031 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493010910 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218493010911 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 218493010913 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 218493010914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493010915 dimer interface [polypeptide binding]; other site 218493010916 conserved gate region; other site 218493010917 putative PBP binding loops; other site 218493010918 ABC-ATPase subunit interface; other site 218493010919 6 probable transmembrane helices predicted for SBG2032 by TMHMM2.0 at aa 9-31, 133-155, 168-190, 224-246,283-305 and 329-348 218493010921 microcin C ABC transporter permease; Provisional; Region: PRK15021 218493010922 signal peptide predicted for SBG2033 by SignalP 2.0 HMM (Signal peptide probabilty 0.908) with cleavage site probability 0.573 between residues 42 and 43 218493010923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493010924 dimer interface [polypeptide binding]; other site 218493010925 conserved gate region; other site 218493010926 ABC-ATPase subunit interface; other site 218493010927 6 probable transmembrane helices predicted for SBG2033 by TMHMM2.0 at aa 21-43, 142-164, 177-199,203-222, 254-276 and 306-328 218493010930 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 218493010931 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493010932 Walker A/P-loop; other site 218493010933 ATP binding site [chemical binding]; other site 218493010934 Q-loop/lid; other site 218493010935 ABC transporter signature motif; other site 218493010936 Walker B; other site 218493010937 D-loop; other site 218493010938 H-loop/switch region; other site 218493010939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218493010940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493010941 Walker A/P-loop; other site 218493010942 ATP binding site [chemical binding]; other site 218493010943 Q-loop/lid; other site 218493010944 ABC transporter signature motif; other site 218493010945 Walker B; other site 218493010946 D-loop; other site 218493010947 H-loop/switch region; other site 218493010955 hypothetical protein; Provisional; Region: PRK11835 218493010956 signal peptide predicted for SBG2036 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.693 between residues 37 and 38 218493010957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493010958 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 218493010959 putative substrate translocation pore; other site 218493010960 12 probable transmembrane helices predicted for SBG2036 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124,137-159, 163-185, 219-241, 251-273, 286-308, 313-332,345-367 and 372-391 218493010964 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 218493010965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493010966 RNA binding surface [nucleotide binding]; other site 218493010967 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 218493010968 active site 218493010969 uracil binding [chemical binding]; other site 218493010973 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 218493010974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493010975 ATP binding site [chemical binding]; other site 218493010976 putative Mg++ binding site [ion binding]; other site 218493010977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493010978 nucleotide binding region [chemical binding]; other site 218493010979 ATP-binding site [chemical binding]; other site 218493010980 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 218493010984 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 218493010985 5S rRNA interface [nucleotide binding]; other site 218493010986 CTC domain interface [polypeptide binding]; other site 218493010987 L16 interface [polypeptide binding]; other site 218493010989 Nucleoid-associated protein [General function prediction only]; Region: COG3081 218493010990 nucleoid-associated protein NdpA; Validated; Region: PRK00378 218493010992 hypothetical protein; Provisional; Region: PRK13689 218493010994 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 218493010995 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 218493010996 signal peptide predicted for SBG2042 by SignalP 2.0 HMM (Signal peptide probabilty 0.612) with cleavage site probability 0.610 between residues 40 and 41 218493010997 Sulfatase; Region: Sulfatase; pfam00884 218493010999 5 probable transmembrane helices predicted for SBG2042 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191 218493011001 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 218493011003 transcriptional regulator NarP; Provisional; Region: PRK10403 218493011004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493011005 active site 218493011006 phosphorylation site [posttranslational modification] 218493011007 intermolecular recognition site; other site 218493011008 dimerization interface [polypeptide binding]; other site 218493011009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493011010 DNA binding residues [nucleotide binding] 218493011011 dimerization interface [polypeptide binding]; other site 218493011015 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 218493011016 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 218493011017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493011018 binding surface 218493011019 TPR motif; other site 218493011021 1 probable transmembrane helix predicted for SBG2045 by TMHMM2.0 at aa 93-115 218493011022 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 218493011023 signal peptide predicted for SBG2046 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.445 between residues 28 and 29 218493011024 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 218493011025 catalytic residues [active] 218493011026 central insert; other site 218493011029 1 probable transmembrane helix predicted for SBG2046 by TMHMM2.0 at aa 5-24 218493011030 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 218493011031 15 probable transmembrane helices predicted for SBG2047 by TMHMM2.0 at aa 10-29, 41-63, 95-114,121-143, 176-198, 211-233, 248-265, 277-299, 314-332,353-375, 390-412, 425-444, 448-470, 482-504 and 610-629 218493011034 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 218493011036 1 probable transmembrane helix predicted for SBG2048 by TMHMM2.0 at aa 72-94 218493011037 heme exporter protein CcmC; Region: ccmC; TIGR01191 218493011038 6 probable transmembrane helices predicted for SBG2049 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 124-146,158-180 and 204-226 218493011040 heme exporter protein CcmB; Region: ccmB; TIGR01190 218493011042 6 probable transmembrane helices predicted for SBG2050 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150,157-179 and 194-216 218493011043 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 218493011044 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 218493011045 Walker A/P-loop; other site 218493011046 ATP binding site [chemical binding]; other site 218493011047 Q-loop/lid; other site 218493011048 ABC transporter signature motif; other site 218493011049 Walker B; other site 218493011050 D-loop; other site 218493011051 H-loop/switch region; other site 218493011055 cytochrome c-type protein NapC; Provisional; Region: PRK10617 218493011056 signal peptide predicted for SBG2052 by SignalP 2.0 HMM (Signal peptide probabilty 0.838) with cleavage site probability 0.556 between residues 51 and 52 218493011057 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 218493011062 1 probable transmembrane helix predicted for SBG2052 by TMHMM2.0 at aa 21-43 218493011063 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 218493011064 signal peptide predicted for SBG2053 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 27 and 28 218493011068 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 218493011069 4Fe-4S binding domain; Region: Fer4_5; pfam12801 218493011070 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493011073 4 probable transmembrane helices predicted for SBG2054 by TMHMM2.0 at aa 30-52, 78-100, 138-160 and 170-192 218493011074 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 218493011075 signal peptide predicted for SBG2055 by SignalP 2.0 HMM (Signal peptide probabilty 0.831) with cleavage site probability 0.355 between residues 36 and 37 218493011079 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 218493011080 signal peptide predicted for SBG2056 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.909 between residues 31 and 32 218493011081 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 218493011082 [4Fe-4S] binding site [ion binding]; other site 218493011083 molybdopterin cofactor binding site; other site 218493011084 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 218493011085 molybdopterin cofactor binding site; other site 218493011090 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 218493011092 ferredoxin-type protein; Provisional; Region: PRK10194 218493011097 signal peptide predicted for SBG2059 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25 218493011098 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 218493011099 secondary substrate binding site; other site 218493011100 primary substrate binding site; other site 218493011101 inhibition loop; other site 218493011102 dimerization interface [polypeptide binding]; other site 218493011105 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 218493011106 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 218493011107 Sulfate transporter family; Region: Sulfate_transp; pfam00916 218493011108 11 probable transmembrane helices predicted for SBG2060 by TMHMM2.0 at aa 31-53, 60-82, 97-119,124-146, 156-173, 180-202, 222-244, 273-295, 305-322,329-351 and 371-393 218493011111 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 218493011112 signal peptide predicted for SBG2061 by SignalP 2.0 HMM (Signal peptide probabilty 0.891) with cleavage site probability 0.521 between residues 29 and 30 218493011113 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 218493011114 Walker A/P-loop; other site 218493011115 ATP binding site [chemical binding]; other site 218493011116 Q-loop/lid; other site 218493011117 ABC transporter signature motif; other site 218493011118 Walker B; other site 218493011119 D-loop; other site 218493011120 H-loop/switch region; other site 218493011124 6 probable transmembrane helices predicted for SBG2061 by TMHMM2.0 at aa 15-37, 50-72, 120-142, 149-171,238-260 and 272-294 218493011125 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 218493011127 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 218493011128 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 218493011129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493011130 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218493011131 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218493011132 DNA binding site [nucleotide binding] 218493011133 active site 218493011142 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 218493011143 signal peptide predicted for SBG2064 by SignalP 2.0 HMM (Signal peptide probabilty 0.607) with cleavage site probability 0.299 between residues 29 and 30 218493011144 ApbE family; Region: ApbE; pfam02424 218493011148 signal peptide predicted for SBG2065 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493011149 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218493011150 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218493011151 trimer interface [polypeptide binding]; other site 218493011152 eyelet of channel; other site 218493011156 signal peptide predicted for SBG2066 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.475 between residues 40 and 41 218493011157 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 218493011158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493011159 ATP binding site [chemical binding]; other site 218493011160 G-X-G motif; other site 218493011161 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218493011162 putative binding surface; other site 218493011163 active site 218493011164 2 probable transmembrane helices predicted for SBG2066 by TMHMM2.0 at aa 20-42 and 308-330 218493011167 transcriptional regulator RcsB; Provisional; Region: PRK10840 218493011168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493011169 active site 218493011170 phosphorylation site [posttranslational modification] 218493011171 intermolecular recognition site; other site 218493011172 dimerization interface [polypeptide binding]; other site 218493011173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493011174 DNA binding residues [nucleotide binding] 218493011175 dimerization interface [polypeptide binding]; other site 218493011179 signal peptide predicted for SBG2068 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.411 between residues 32 and 33 218493011180 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 218493011181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493011182 dimer interface [polypeptide binding]; other site 218493011183 phosphorylation site [posttranslational modification] 218493011184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493011185 ATP binding site [chemical binding]; other site 218493011186 Mg2+ binding site [ion binding]; other site 218493011187 G-X-G motif; other site 218493011188 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 218493011189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493011190 active site 218493011191 phosphorylation site [posttranslational modification] 218493011192 intermolecular recognition site; other site 218493011193 dimerization interface [polypeptide binding]; other site 218493011197 2 probable transmembrane helices predicted for SBG2068 by TMHMM2.0 at aa 20-42 and 314-333 218493011198 DNA gyrase subunit A; Validated; Region: PRK05560 218493011199 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 218493011200 CAP-like domain; other site 218493011201 active site 218493011202 primary dimer interface [polypeptide binding]; other site 218493011203 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493011216 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 218493011217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493011218 S-adenosylmethionine binding site [chemical binding]; other site 218493011220 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 218493011221 ATP cone domain; Region: ATP-cone; pfam03477 218493011222 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218493011223 active site 218493011224 dimer interface [polypeptide binding]; other site 218493011225 catalytic residues [active] 218493011226 effector binding site; other site 218493011227 R2 peptide binding site; other site 218493011233 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218493011234 dimer interface [polypeptide binding]; other site 218493011235 putative radical transfer pathway; other site 218493011236 diiron center [ion binding]; other site 218493011237 tyrosyl radical; other site 218493011240 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 218493011241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218493011242 catalytic loop [active] 218493011243 iron binding site [ion binding]; other site 218493011246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493011247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493011248 putative substrate translocation pore; other site 218493011249 12 probable transmembrane helices predicted for SBG2074 by TMHMM2.0 at aa 13-35, 45-64, 76-95,100-122, 134-153, 163-185, 212-234, 239-261, 273-290,295-317, 330-352 and 357-379 218493011251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493011252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493011253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218493011254 dimerization interface [polypeptide binding]; other site 218493011258 signal peptide predicted for SBG2076 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.892 between residues 25 and 26 218493011259 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 218493011260 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 218493011261 active site 218493011262 catalytic site [active] 218493011263 metal binding site [ion binding]; metal-binding site 218493011266 1 probable transmembrane helix predicted for SBG2076 by TMHMM2.0 at aa 7-26 218493011267 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 218493011268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493011269 putative substrate translocation pore; other site 218493011270 12 probable transmembrane helices predicted for SBG2077 by TMHMM2.0 at aa 28-45, 65-87, 94-116,120-142, 161-183, 188-207, 254-273, 293-312, 319-341,351-373, 386-408 and 418-437 218493011273 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 218493011274 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218493011275 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218493011280 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 218493011281 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 218493011283 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 218493011284 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493011285 Cysteine-rich domain; Region: CCG; pfam02754 218493011286 Cysteine-rich domain; Region: CCG; pfam02754 218493011291 insertion wrt S. Typhi CT18 218493011293 hypothetical protein; Provisional; Region: PRK09956 218493011294 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 218493011296 hypothetical protein; Provisional; Region: PRK03673 218493011297 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 218493011298 putative MPT binding site; other site 218493011299 Competence-damaged protein; Region: CinA; cl00666 218493011301 YfaZ precursor; Region: YfaZ; pfam07437 218493011302 signal peptide predicted for SBG2083 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 21 and 22 218493011304 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 218493011307 signal peptide predicted for SBG2085 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.672 between residues 35 and 36 218493011308 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 218493011309 catalytic core [active] 218493011311 1 probable transmembrane helix predicted for SBG2085 by TMHMM2.0 at aa 13-35 218493011312 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 218493011313 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218493011314 inhibitor-cofactor binding pocket; inhibition site 218493011315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493011316 catalytic residue [active] 218493011318 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 218493011319 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 218493011320 Ligand binding site; other site 218493011321 Putative Catalytic site; other site 218493011322 DXD motif; other site 218493011324 2 probable transmembrane helices predicted for SBG2087 by TMHMM2.0 at aa 235-257 and 272-294 218493011325 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 218493011326 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 218493011327 active site 218493011328 substrate binding site [chemical binding]; other site 218493011329 cosubstrate binding site; other site 218493011330 catalytic site [active] 218493011331 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 218493011332 active site 218493011333 hexamer interface [polypeptide binding]; other site 218493011334 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 218493011335 NAD binding site [chemical binding]; other site 218493011336 substrate binding site [chemical binding]; other site 218493011337 active site 218493011341 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 218493011342 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 218493011343 putative active site [active] 218493011344 putative catalytic site [active] 218493011345 putative Zn binding site [ion binding]; other site 218493011347 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 218493011348 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 218493011350 12 probable transmembrane helices predicted for SBG2090 by TMHMM2.0 at aa 7-29, 82-104, 113-135,139-156, 168-190, 205-227, 258-280, 290-307, 314-331,346-368, 381-400 and 405-424 218493011353 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 218493011354 signal peptide predicted for SBG2091 by SignalP 2.0 HMM (Signal peptide probabilty 0.704) with cleavage site probability 0.365 between residues 21 and 22 218493011355 3 probable transmembrane helices predicted for SBG2091 by TMHMM2.0 at aa 36-58, 63-85 and 92-110 218493011357 signal transduction protein PmrD; Provisional; Region: PRK15450 218493011358 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 218493011359 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 218493011360 acyl-activating enzyme (AAE) consensus motif; other site 218493011361 putative AMP binding site [chemical binding]; other site 218493011362 putative active site [active] 218493011363 putative CoA binding site [chemical binding]; other site 218493011366 O-succinylbenzoate synthase; Provisional; Region: PRK05105 218493011367 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 218493011368 active site 218493011370 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 218493011371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218493011372 substrate binding site [chemical binding]; other site 218493011373 oxyanion hole (OAH) forming residues; other site 218493011374 trimer interface [polypeptide binding]; other site 218493011377 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 218493011379 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 218493011380 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 218493011381 dimer interface [polypeptide binding]; other site 218493011382 tetramer interface [polypeptide binding]; other site 218493011383 PYR/PP interface [polypeptide binding]; other site 218493011384 TPP binding site [chemical binding]; other site 218493011385 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 218493011386 TPP-binding site; other site 218493011388 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 218493011389 isochorismate synthases; Region: isochor_syn; TIGR00543 218493011391 hypothetical protein; Provisional; Region: PRK10404 218493011393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493011394 Coenzyme A binding pocket [chemical binding]; other site 218493011396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218493011399 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 218493011400 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 218493011401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493011402 active site 218493011403 phosphorylation site [posttranslational modification] 218493011404 intermolecular recognition site; other site 218493011405 dimerization interface [polypeptide binding]; other site 218493011408 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 218493011409 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218493011410 11 probable transmembrane helices predicted for SBG2103 by TMHMM2.0 at aa 12-34, 65-87, 99-121,141-163, 176-198, 208-230, 237-259, 269-291, 311-333,348-370 and 390-412 218493011412 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 218493011413 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218493011414 14 probable transmembrane helices predicted for SBG2104 by TMHMM2.0 at aa 4-18, 30-49, 81-103,115-134, 139-161, 174-196, 222-244, 251-273, 288-307,314-336, 341-363, 384-406, 416-438 and 459-481 218493011416 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 218493011417 signal peptide predicted for SBG2105 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.760 between residues 26 and 27 218493011418 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 218493011419 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218493011420 16 probable transmembrane helices predicted for SBG2105 by TMHMM2.0 at aa 4-21, 28-50, 84-106,113-132, 136-158, 171-193, 213-235, 248-267, 277-299,306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612 218493011424 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 218493011425 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 218493011427 5 probable transmembrane helices predicted for SBG2106 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 218493011428 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 218493011429 4Fe-4S binding domain; Region: Fer4; pfam00037 218493011430 4Fe-4S binding domain; Region: Fer4; pfam00037 218493011435 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 218493011436 9 probable transmembrane helices predicted for SBG2108 by TMHMM2.0 at aa 13-35, 50-69, 81-103, 113-135,155-174, 184-206, 235-257, 267-289 and 302-324 218493011440 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 218493011441 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218493011442 catalytic loop [active] 218493011443 iron binding site [ion binding]; other site 218493011444 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 218493011445 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 218493011446 [4Fe-4S] binding site [ion binding]; other site 218493011447 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 218493011455 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 218493011456 SLBB domain; Region: SLBB; pfam10531 218493011457 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 218493011461 NADH dehydrogenase subunit E; Validated; Region: PRK07539 218493011462 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 218493011463 putative dimer interface [polypeptide binding]; other site 218493011464 [2Fe-2S] cluster binding site [ion binding]; other site 218493011467 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 218493011468 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 218493011469 NADH dehydrogenase subunit D; Validated; Region: PRK06075 218493011473 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 218493011477 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 218493011479 3 probable transmembrane helices predicted for SBG2114 by TMHMM2.0 at aa 15-37, 68-90 and 100-122 218493011481 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 218493011482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493011483 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 218493011484 putative dimerization interface [polypeptide binding]; other site 218493011489 aminotransferase AlaT; Validated; Region: PRK09265 218493011490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493011491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493011492 homodimer interface [polypeptide binding]; other site 218493011493 catalytic residue [active] 218493011495 5'-nucleotidase; Provisional; Region: PRK03826 218493011497 signal peptide predicted for SBG2119 by SignalP 2.0 HMM (Signal peptide probabilty 0.872) with cleavage site probability 0.645 between residues 20 and 21 218493011498 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 218493011499 transmembrane helices; other site 218493011500 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493011501 TrkA-C domain; Region: TrkA_C; pfam02080 218493011502 TrkA-C domain; Region: TrkA_C; pfam02080 218493011503 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 218493011504 11 probable transmembrane helices predicted for SBG2119 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 96-118,138-160, 173-195, 427-449, 462-480, 500-522, 542-564 and 584-606 218493011511 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 218493011512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493011513 motif II; other site 218493011515 hypothetical protein; Validated; Region: PRK05445 218493011517 hypothetical protein; Provisional; Region: PRK01816 218493011519 2 probable transmembrane helices predicted for SBG2122 by TMHMM2.0 at aa 46-65 and 69-91 218493011520 propionate/acetate kinase; Provisional; Region: PRK12379 218493011521 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 218493011525 phosphate acetyltransferase; Reviewed; Region: PRK05632 218493011526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218493011527 DRTGG domain; Region: DRTGG; pfam07085 218493011528 phosphate acetyltransferase; Region: pta; TIGR00651 218493011531 hypothetical protein; Provisional; Region: PRK11588 218493011532 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 218493011534 11 probable transmembrane helices predicted for SBG2125 by TMHMM2.0 at aa 19-41, 106-127, 148-165,175-197, 204-226, 230-252, 287-309, 314-336, 349-371,398-415 and 481-503 218493011536 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 218493011537 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218493011538 PYR/PP interface [polypeptide binding]; other site 218493011539 dimer interface [polypeptide binding]; other site 218493011540 TPP binding site [chemical binding]; other site 218493011541 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218493011544 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218493011545 TPP-binding site [chemical binding]; other site 218493011546 dimer interface [polypeptide binding]; other site 218493011548 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 218493011549 11 probable transmembrane helices predicted for SBG2128 by TMHMM2.0 at aa 10-32, 39-61, 95-114,121-143, 147-169, 226-243, 258-280, 310-332, 342-364,377-399 and 423-445 218493011551 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218493011552 active site 218493011553 P-loop; other site 218493011554 phosphorylation site [posttranslational modification] 218493011556 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493011557 active site 218493011558 phosphorylation site [posttranslational modification] 218493011560 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493011561 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493011562 DNA binding site [nucleotide binding] 218493011563 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218493011564 putative dimerization interface [polypeptide binding]; other site 218493011565 putative ligand binding site [chemical binding]; other site 218493011569 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 218493011570 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 218493011571 nudix motif; other site 218493011573 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 218493011574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218493011575 active site 218493011576 metal binding site [ion binding]; metal-binding site 218493011577 homotetramer interface [polypeptide binding]; other site 218493011580 glutathione S-transferase; Provisional; Region: PRK15113 218493011581 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 218493011582 C-terminal domain interface [polypeptide binding]; other site 218493011583 GSH binding site (G-site) [chemical binding]; other site 218493011584 dimer interface [polypeptide binding]; other site 218493011585 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 218493011586 N-terminal domain interface [polypeptide binding]; other site 218493011587 putative dimer interface [polypeptide binding]; other site 218493011588 putative substrate binding pocket (H-site) [chemical binding]; other site 218493011590 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 218493011591 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 218493011592 C-terminal domain interface [polypeptide binding]; other site 218493011593 GSH binding site (G-site) [chemical binding]; other site 218493011594 dimer interface [polypeptide binding]; other site 218493011595 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 218493011596 N-terminal domain interface [polypeptide binding]; other site 218493011597 putative dimer interface [polypeptide binding]; other site 218493011598 active site 218493011601 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 218493011602 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 218493011603 putative NAD(P) binding site [chemical binding]; other site 218493011604 putative active site [active] 218493011607 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 218493011608 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218493011609 Walker A/P-loop; other site 218493011610 ATP binding site [chemical binding]; other site 218493011611 Q-loop/lid; other site 218493011612 ABC transporter signature motif; other site 218493011613 Walker B; other site 218493011614 D-loop; other site 218493011615 H-loop/switch region; other site 218493011619 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493011620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493011621 dimer interface [polypeptide binding]; other site 218493011622 conserved gate region; other site 218493011623 putative PBP binding loops; other site 218493011624 ABC-ATPase subunit interface; other site 218493011626 4 probable transmembrane helices predicted for SBG2138 by TMHMM2.0 at aa 25-47, 57-79, 167-189 and 199-221 218493011628 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218493011629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493011630 dimer interface [polypeptide binding]; other site 218493011631 conserved gate region; other site 218493011632 putative PBP binding loops; other site 218493011633 ABC-ATPase subunit interface; other site 218493011635 5 probable transmembrane helices predicted for SBG2139 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213 218493011638 signal peptide predicted for SBG2140 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 22 and 23 218493011639 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 218493011640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493011641 substrate binding pocket [chemical binding]; other site 218493011642 membrane-bound complex binding site; other site 218493011643 hinge residues; other site 218493011646 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 218493011647 signal peptide predicted for SBG2141 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.901 between residues 22 and 23 218493011648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493011649 substrate binding pocket [chemical binding]; other site 218493011650 membrane-bound complex binding site; other site 218493011651 hinge residues; other site 218493011654 1 probable transmembrane helix predicted for SBG2141 by TMHMM2.0 at aa 5-24 218493011655 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 218493011656 Flavoprotein; Region: Flavoprotein; pfam02441 218493011660 amidophosphoribosyltransferase; Provisional; Region: PRK09246 218493011661 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 218493011662 active site 218493011663 tetramer interface [polypeptide binding]; other site 218493011664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493011665 active site 218493011670 colicin V production protein; Provisional; Region: PRK10845 218493011671 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 218493011673 4 probable transmembrane helices predicted for SBG2144 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 218493011675 cell division protein DedD; Provisional; Region: PRK11633 218493011676 Sporulation related domain; Region: SPOR; pfam05036 218493011678 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 218493011679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493011680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493011685 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 218493011686 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 218493011688 hypothetical protein; Provisional; Region: PRK10847 218493011689 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218493011690 4 probable transmembrane helices predicted for SBG2149 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208 218493011692 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 218493011693 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 218493011694 dimerization interface 3.5A [polypeptide binding]; other site 218493011695 active site 218493011698 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 218493011699 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218493011703 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 218493011704 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 218493011705 ligand binding site [chemical binding]; other site 218493011706 NAD binding site [chemical binding]; other site 218493011707 catalytic site [active] 218493011708 homodimer interface [polypeptide binding]; other site 218493011713 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 218493011714 1 probable transmembrane helix predicted for SBG2153 by TMHMM2.0 at aa 310-332 218493011715 putative transporter; Provisional; Region: PRK12382 218493011716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493011717 12 probable transmembrane helices predicted for SBG2154 by TMHMM2.0 at aa 20-42, 52-71, 83-105,120-142, 149-171, 176-198, 211-233, 248-270, 277-299,303-325, 338-360 and 370-389 218493011721 this CDS appears to lack the 3'terminus 218493011722 this CDS appears to lack the 5'terminus 218493011723 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 218493011724 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218493011725 dimer interface [polypeptide binding]; other site 218493011726 active site 218493011731 Uncharacterized conserved protein [Function unknown]; Region: COG4121 218493011732 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 218493011736 YfcL protein; Region: YfcL; pfam08891 218493011738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 218493011740 signal peptide predicted for SBG2161 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.412 between residues 53 and 54 218493011741 hypothetical protein; Provisional; Region: PRK10621 218493011742 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 218493011744 7 probable transmembrane helices predicted for SBG2161 by TMHMM2.0 at aa 7-28, 32-54, 85-104, 108-127,139-158, 163-180 and 193-215 218493011746 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 218493011747 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 218493011748 signal peptide predicted for SBG2162 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 19 and 20 218493011750 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 218493011751 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 218493011752 Tetramer interface [polypeptide binding]; other site 218493011753 active site 218493011754 FMN-binding site [chemical binding]; other site 218493011759 HemK family putative methylases; Region: hemK_fam; TIGR00536 218493011760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493011761 S-adenosylmethionine binding site [chemical binding]; other site 218493011765 hypothetical protein; Provisional; Region: PRK04946 218493011766 Smr domain; Region: Smr; pfam01713 218493011768 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218493011769 catalytic core [active] 218493011771 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 218493011772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218493011773 substrate binding site [chemical binding]; other site 218493011774 oxyanion hole (OAH) forming residues; other site 218493011775 trimer interface [polypeptide binding]; other site 218493011776 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 218493011777 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218493011783 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 218493011784 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218493011785 dimer interface [polypeptide binding]; other site 218493011786 active site 218493011792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 218493011794 signal peptide predicted for SBG2170 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 27 and 28 218493011795 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 218493011797 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 218493011798 signal peptide predicted for SBG2171 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.315 between residues 22 and 23 218493011801 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 218493011802 6 probable transmembrane helices predicted for SBG2172 by TMHMM2.0 at aa 62-84, 94-116, 137-159, 190-209,216-235 and 255-277 218493011803 P4-family prophage 218493011804 integrase; Provisional; Region: PRK09692 218493011805 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218493011806 active site 218493011807 Int/Topo IB signature motif; other site 218493011809 Ash protein family; Region: Phage_ASH; pfam10554 218493011810 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 218493011812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 218493011813 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218493011814 active site 218493011815 metal binding site [ion binding]; metal-binding site 218493011816 interdomain interaction site; other site 218493011817 Domain of unknown function (DUF927); Region: DUF927; cl12098 218493011819 multiple promoter invertase; Provisional; Region: mpi; PRK13413 218493011820 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 218493011821 catalytic residues [active] 218493011822 catalytic nucleophile [active] 218493011823 Presynaptic Site I dimer interface [polypeptide binding]; other site 218493011824 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 218493011825 Synaptic Flat tetramer interface [polypeptide binding]; other site 218493011826 Synaptic Site I dimer interface [polypeptide binding]; other site 218493011827 DNA binding site [nucleotide binding] 218493011831 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 218493011833 CDS appears to lack the 3' region 218493011834 Fimbrial protein; Region: Fimbrial; cl01416 218493011835 signal peptide predicted for SBG2186 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.942 between residues 18 and 19 218493011836 sbc fimbrial operon 218493011837 1 probable transmembrane helix predicted for SBG2186 by TMHMM2.0 at aa 5-27 218493011838 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 218493011839 signal peptide predicted for SBG2187 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.523 between residues 21 and 22 218493011842 signal peptide predicted for SBG2188 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.838 between residues 22 and 23 218493011843 Fimbrial protein; Region: Fimbrial; pfam00419 218493011844 signal peptide predicted for SBG2189 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 19 and 20 218493011845 Fimbrial protein; Region: Fimbrial; pfam00419 218493011846 signal peptide predicted for SBG2190 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493011847 Fimbrial protein; Region: Fimbrial; pfam00419 218493011848 signal peptide predicted for SBG2191 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.495 between residues 20 and 21 218493011849 Fimbrial protein; Region: Fimbrial; cl01416 218493011850 signal peptide predicted for SBG2192 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.605 between residues 21 and 22 218493011851 1 probable transmembrane helix predicted for SBG2192 by TMHMM2.0 at aa 7-29 218493011852 signal peptide predicted for SBG2193 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.501 between residues 25 and 26 218493011853 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 218493011854 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493011855 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493011859 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 218493011860 PapC N-terminal domain; Region: PapC_N; pfam13954 218493011861 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493011864 1 probable transmembrane helix predicted for SBG2194 by TMHMM2.0 at aa 27-44 218493011865 signal peptide predicted for SBG2195 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.797 between residues 22 and 23 218493011866 fimbrial protein PefA; Provisional; Region: PRK15214 218493011869 1 probable transmembrane helix predicted for SBG2195 by TMHMM2.0 at aa 5-27 218493011871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493011872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493011878 outer membrane protease; Reviewed; Region: PRK10993 218493011879 signal peptide predicted for SBG2201 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21 218493011884 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 218493011885 signal peptide predicted for SBG2202 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.344 between residues 24 and 25 218493011886 3 probable transmembrane helices predicted for SBG2202 by TMHMM2.0 at aa 2-24, 28-47 and 54-76 218493011887 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218493011888 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218493011889 putative acyl-acceptor binding pocket; other site 218493011891 1 probable transmembrane helix predicted for SBG2203 by TMHMM2.0 at aa 15-37 218493011893 aminotransferase; Validated; Region: PRK08175 218493011894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493011895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493011896 homodimer interface [polypeptide binding]; other site 218493011897 catalytic residue [active] 218493011899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493011900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493011904 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218493011905 dimerization domain swap beta strand [polypeptide binding]; other site 218493011906 regulatory protein interface [polypeptide binding]; other site 218493011907 active site 218493011908 regulatory phosphorylation site [posttranslational modification]; other site 218493011909 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 218493011910 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218493011911 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218493011912 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218493011913 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493011914 active site 218493011915 phosphorylation site [posttranslational modification] 218493011921 exoaminopeptidase; Provisional; Region: PRK09961 218493011922 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 218493011923 oligomer interface [polypeptide binding]; other site 218493011924 active site 218493011925 metal binding site [ion binding]; metal-binding site 218493011927 aminopeptidase; Provisional; Region: PRK09795 218493011928 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 218493011929 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 218493011930 active site 218493011933 signal peptide predicted for SBG2209 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.238 between residues 18 and 19 218493011934 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 218493011935 10 probable transmembrane helices predicted for SBG2209 by TMHMM2.0 at aa 46-68, 97-119, 126-145,155-177, 198-220, 240-262, 275-297, 317-335, 342-364 and 379-401 218493011937 signal peptide predicted for SBG2210 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.785 between residues 21 and 22 218493011938 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218493011939 active site 218493011940 P-loop; other site 218493011941 phosphorylation site [posttranslational modification] 218493011943 glucokinase; Provisional; Region: glk; PRK00292 218493011944 glucokinase, proteobacterial type; Region: glk; TIGR00749 218493011946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 218493011947 signal peptide predicted for SBG2212 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.454 between residues 29 and 30 218493011948 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 218493011949 Cl- selectivity filter; other site 218493011950 Cl- binding residues [ion binding]; other site 218493011951 pore gating glutamate residue; other site 218493011952 dimer interface [polypeptide binding]; other site 218493011953 11 probable transmembrane helices predicted for SBG2212 by TMHMM2.0 at aa 9-31, 57-74, 95-117,148-170, 186-208, 223-245, 258-280, 295-317, 322-341,345-363 and 376-398 218493011955 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 218493011956 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 218493011957 dimer interface [polypeptide binding]; other site 218493011958 PYR/PP interface [polypeptide binding]; other site 218493011959 TPP binding site [chemical binding]; other site 218493011960 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218493011961 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 218493011962 TPP-binding site [chemical binding]; other site 218493011963 dimer interface [polypeptide binding]; other site 218493011969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493011970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493011971 active site 218493011972 catalytic tetrad [active] 218493011974 signal peptide predicted for SBG2215 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 21 and 22 218493011975 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 218493011976 1 probable transmembrane helix predicted for SBG2215 by TMHMM2.0 at aa 5-27 218493011977 manganese transport protein MntH; Reviewed; Region: PRK00701 218493011978 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 218493011979 11 probable transmembrane helices predicted for SBG2216 by TMHMM2.0 at aa 17-39, 54-76, 96-118,123-145, 157-176, 196-218, 239-261, 281-303, 324-343,348-370 and 390-412 218493011981 signal peptide predicted for SBG2217 by SignalP 2.0 HMM (Signal peptide probabilty 0.806) with cleavage site probability 0.394 between residues 23 and 24 218493011982 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 218493011983 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 218493011984 Nucleoside recognition; Region: Gate; pfam07670 218493011985 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 218493011987 9 probable transmembrane helices predicted for SBG2217 by TMHMM2.0 at aa 4-23, 36-57, 86-108, 167-189,193-215, 244-266, 276-298, 340-362 and 377-399 218493011990 signal peptide predicted for SBG2218 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.494 between residues 30 and 31 218493011991 MASE1; Region: MASE1; pfam05231 218493011992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218493011993 diguanylate cyclase; Region: GGDEF; smart00267 218493011994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493011998 9 probable transmembrane helices predicted for SBG2218 by TMHMM2.0 at aa 10-32, 39-61, 86-108, 121-143,163-185, 215-234, 238-255, 262-279 and 289-311 218493011999 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 218493012001 Winged helix-turn helix; Region: HTH_29; pfam13551 218493012002 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 218493012004 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 218493012005 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218493012006 active site 218493012007 HIGH motif; other site 218493012008 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218493012009 active site 218493012010 KMSKS motif; other site 218493012013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493012014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493012015 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 218493012016 putative dimerization interface [polypeptide binding]; other site 218493012020 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 218493012021 signal peptide predicted for SBG2223 by SignalP 2.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.647 between residues 28 and 29 218493012022 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 218493012023 9 probable transmembrane helices predicted for SBG2223 by TMHMM2.0 at aa 7-24, 29-48, 69-91, 101-123,130-152, 167-189, 202-224, 229-251 and 272-294 218493012025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 218493012026 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 218493012027 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 218493012028 nucleotide binding pocket [chemical binding]; other site 218493012029 K-X-D-G motif; other site 218493012030 catalytic site [active] 218493012031 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218493012032 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 218493012033 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 218493012034 Dimer interface [polypeptide binding]; other site 218493012035 BRCT sequence motif; other site 218493012043 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 218493012044 cell division protein ZipA; Provisional; Region: PRK03427 218493012045 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 218493012046 FtsZ protein binding site [polypeptide binding]; other site 218493012048 1 probable transmembrane helix predicted for SBG2226 by TMHMM2.0 at aa 22-44 218493012049 putative sulfate transport protein CysZ; Validated; Region: PRK04949 218493012050 4 probable transmembrane helices predicted for SBG2227 by TMHMM2.0 at aa 32-54, 69-91, 152-174 and 221-243 218493012052 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218493012053 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218493012054 dimer interface [polypeptide binding]; other site 218493012055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493012056 catalytic residue [active] 218493012060 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218493012061 dimerization domain swap beta strand [polypeptide binding]; other site 218493012062 regulatory protein interface [polypeptide binding]; other site 218493012063 active site 218493012064 regulatory phosphorylation site [posttranslational modification]; other site 218493012068 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 218493012069 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218493012070 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218493012071 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218493012077 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218493012078 HPr interaction site; other site 218493012079 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218493012080 active site 218493012081 phosphorylation site [posttranslational modification] 218493012084 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 218493012085 dimer interface [polypeptide binding]; other site 218493012086 pyridoxamine kinase; Validated; Region: PRK05756 218493012087 pyridoxal binding site [chemical binding]; other site 218493012088 ATP binding site [chemical binding]; other site 218493012090 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 218493012091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493012092 DNA-binding site [nucleotide binding]; DNA binding site 218493012093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493012094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493012095 homodimer interface [polypeptide binding]; other site 218493012096 catalytic residue [active] 218493012100 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 218493012101 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 218493012102 catalytic triad [active] 218493012104 cysteine synthase B; Region: cysM; TIGR01138 218493012105 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218493012106 dimer interface [polypeptide binding]; other site 218493012107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493012108 catalytic residue [active] 218493012111 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 218493012112 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 218493012113 Walker A/P-loop; other site 218493012114 ATP binding site [chemical binding]; other site 218493012115 Q-loop/lid; other site 218493012116 ABC transporter signature motif; other site 218493012117 Walker B; other site 218493012118 D-loop; other site 218493012119 H-loop/switch region; other site 218493012120 TOBE-like domain; Region: TOBE_3; pfam12857 218493012124 sulfate transport protein; Provisional; Region: cysT; CHL00187 218493012125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493012126 dimer interface [polypeptide binding]; other site 218493012127 conserved gate region; other site 218493012128 putative PBP binding loops; other site 218493012129 ABC-ATPase subunit interface; other site 218493012131 6 probable transmembrane helices predicted for SBG2238 by TMHMM2.0 at aa 20-42, 69-91, 103-125, 140-162,201-223 and 246-268 218493012133 signal peptide predicted for SBG2239 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.435 between residues 36 and 37 218493012134 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218493012135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493012136 dimer interface [polypeptide binding]; other site 218493012137 conserved gate region; other site 218493012138 putative PBP binding loops; other site 218493012139 ABC-ATPase subunit interface; other site 218493012141 7 probable transmembrane helices predicted for SBG2239 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160,188-205, 212-234 and 244-266 218493012143 thiosulfate transporter subunit; Provisional; Region: PRK10852 218493012144 signal peptide predicted for SBG2240 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 25 and 26 218493012145 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218493012149 short chain dehydrogenase; Provisional; Region: PRK08226 218493012150 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 218493012151 NAD binding site [chemical binding]; other site 218493012152 homotetramer interface [polypeptide binding]; other site 218493012153 homodimer interface [polypeptide binding]; other site 218493012154 active site 218493012156 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 218493012158 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 218493012159 signal peptide predicted for SBG2243 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.463 between residues 27 and 28 218493012160 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 218493012163 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 218493012164 4 probable transmembrane helices predicted for SBG2244 by TMHMM2.0 at aa 21-43, 58-80, 93-110 and 115-137 218493012165 putative acetyltransferase; Provisional; Region: PRK03624 218493012166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493012167 Coenzyme A binding pocket [chemical binding]; other site 218493012169 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 218493012170 signal peptide predicted for SBG2246 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 34 and 35 218493012171 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218493012172 active site 218493012173 metal binding site [ion binding]; metal-binding site 218493012175 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 218493012176 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 218493012179 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 218493012180 Malic enzyme, N-terminal domain; Region: malic; pfam00390 218493012181 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 218493012182 putative NAD(P) binding site [chemical binding]; other site 218493012183 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 218493012188 transaldolase-like protein; Provisional; Region: PTZ00411 218493012189 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 218493012190 active site 218493012191 dimer interface [polypeptide binding]; other site 218493012192 catalytic residue [active] 218493012196 transketolase; Reviewed; Region: PRK12753 218493012197 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218493012198 TPP-binding site [chemical binding]; other site 218493012199 dimer interface [polypeptide binding]; other site 218493012200 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 218493012201 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218493012202 PYR/PP interface [polypeptide binding]; other site 218493012203 dimer interface [polypeptide binding]; other site 218493012204 TPP binding site [chemical binding]; other site 218493012205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218493012212 signal peptide predicted for SBG2252 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493012213 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 218493012215 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 218493012216 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218493012217 dimer interface [polypeptide binding]; other site 218493012218 ADP-ribose binding site [chemical binding]; other site 218493012219 active site 218493012220 nudix motif; other site 218493012221 metal binding site [ion binding]; metal-binding site 218493012223 putative periplasmic esterase; Provisional; Region: PRK03642 218493012224 signal peptide predicted for SBG2254 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 19 and 20 218493012225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 218493012227 3 probable transmembrane helices predicted for SBG2255 by TMHMM2.0 at aa 34-56, 85-107 and 140-162 218493012229 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 218493012230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 218493012231 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493012238 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 218493012239 signal peptide predicted for SBG2260 by SignalP 2.0 HMM (Signal peptide probabilty 0.920) with cleavage site probability 0.338 between residues 40 and 41 218493012240 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 218493012241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493012242 dimerization interface [polypeptide binding]; other site 218493012243 Histidine kinase; Region: HisKA_3; pfam07730 218493012244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493012245 ATP binding site [chemical binding]; other site 218493012246 Mg2+ binding site [ion binding]; other site 218493012247 G-X-G motif; other site 218493012248 2 probable transmembrane helices predicted for SBG2260 by TMHMM2.0 at aa 15-37 and 147-169 218493012252 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 218493012253 signal peptide predicted for SBG2261 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.693 between residues 34 and 35 218493012254 Protein export membrane protein; Region: SecD_SecF; cl14618 218493012256 11 probable transmembrane helices predicted for SBG2261 by TMHMM2.0 at aa 10-32, 337-359, 364-386,438-460, 470-492, 538-560, 868-890, 897-919, 924-946,972-989 and 1004-1026 218493012257 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 218493012258 ArsC family; Region: ArsC; pfam03960 218493012259 putative catalytic residues [active] 218493012261 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 218493012262 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 218493012263 metal binding site [ion binding]; metal-binding site 218493012264 dimer interface [polypeptide binding]; other site 218493012269 hypothetical protein; Provisional; Region: PRK13664 218493012270 1 probable transmembrane helix predicted for SBG2264 by TMHMM2.0 at aa 5-24 218493012271 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 218493012272 Helicase; Region: Helicase_RecD; pfam05127 218493012273 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 218493012274 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 218493012279 Predicted metalloprotease [General function prediction only]; Region: COG2321 218493012280 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 218493012283 1 probable transmembrane helix predicted for SBG2266 by TMHMM2.0 at aa 38-60 218493012284 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 218493012285 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 218493012286 ATP binding site [chemical binding]; other site 218493012287 active site 218493012288 substrate binding site [chemical binding]; other site 218493012292 lipoprotein; Provisional; Region: PRK11679 218493012293 signal peptide predicted for SBG2268 by SignalP 2.0 HMM (Signal peptide probabilty 0.782) with cleavage site probability 0.237 between residues 27 and 28 218493012294 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 218493012298 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 218493012299 dihydrodipicolinate synthase; Region: dapA; TIGR00674 218493012300 dimer interface [polypeptide binding]; other site 218493012301 active site 218493012302 catalytic residue [active] 218493012306 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 218493012307 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 218493012308 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 218493012311 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 218493012312 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 218493012313 catalytic triad [active] 218493012316 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 218493012318 signal peptide predicted for SBG2273 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.770 between residues 36 and 37 218493012319 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 218493012320 fructuronate transporter; Provisional; Region: PRK10034; cl15264 218493012321 11 probable transmembrane helices predicted for SBG2273 by TMHMM2.0 at aa 4-21, 28-50, 55-77, 98-120,172-194, 215-237, 242-261, 274-296, 306-328, 341-363 and 402-421 218493012323 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 218493012324 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 218493012325 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 218493012327 signal peptide predicted for SBG2275 by SignalP 2.0 HMM (Signal peptide probabilty 0.833) with cleavage site probability 0.312 between residues 49 and 50 218493012328 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 218493012329 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218493012331 7 probable transmembrane helices predicted for SBG2275 by TMHMM2.0 at aa 20-51, 71-93, 155-177, 217-236,251-273, 278-300 and 310-332 218493012332 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 218493012333 signal peptide predicted for SBG2276 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 27 and 28 218493012334 Peptidase family M48; Region: Peptidase_M48; cl12018 218493012336 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 218493012337 ArsC family; Region: ArsC; pfam03960 218493012338 catalytic residues [active] 218493012340 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 218493012341 DNA replication initiation factor; Provisional; Region: PRK08084 218493012343 uracil transporter; Provisional; Region: PRK10720 218493012344 12 probable transmembrane helices predicted for SBG2279 by TMHMM2.0 at aa 13-35, 39-61, 68-85, 89-108,121-143, 158-180, 185-207, 227-249, 304-326, 331-353,365-387 and 392-411 218493012348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493012349 active site 218493012351 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 218493012352 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 218493012353 dimerization interface [polypeptide binding]; other site 218493012354 putative ATP binding site [chemical binding]; other site 218493012357 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 218493012358 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 218493012359 active site 218493012360 substrate binding site [chemical binding]; other site 218493012361 cosubstrate binding site; other site 218493012362 catalytic site [active] 218493012365 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 218493012366 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 218493012367 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 218493012368 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 218493012369 putative active site [active] 218493012370 catalytic site [active] 218493012371 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 218493012372 domain interface [polypeptide binding]; other site 218493012373 active site 218493012374 catalytic site [active] 218493012376 exopolyphosphatase; Provisional; Region: PRK10854 218493012377 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 218493012379 signal peptide predicted for SBG2285 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.900 between residues 36 and 37 218493012380 MASE1; Region: MASE1; pfam05231 218493012381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218493012382 diguanylate cyclase; Region: GGDEF; smart00267 218493012383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493012386 8 probable transmembrane helices predicted for SBG2285 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 124-146,166-188, 216-238, 253-275 and 295-317 218493012387 signal peptide predicted for SBG2286 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 25 and 26 218493012388 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 218493012391 signal peptide predicted for SBG2287 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.715 between residues 19 and 20 218493012392 GMP synthase; Reviewed; Region: guaA; PRK00074 218493012393 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 218493012394 AMP/PPi binding site [chemical binding]; other site 218493012395 candidate oxyanion hole; other site 218493012396 catalytic triad [active] 218493012397 potential glutamine specificity residues [chemical binding]; other site 218493012398 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 218493012399 ATP Binding subdomain [chemical binding]; other site 218493012400 Ligand Binding sites [chemical binding]; other site 218493012401 Dimerization subdomain; other site 218493012406 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 218493012407 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 218493012408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 218493012409 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 218493012410 active site 218493012414 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 218493012415 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 218493012416 generic binding surface II; other site 218493012417 generic binding surface I; other site 218493012420 signal peptide predicted for SBG2291 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.685 between residues 29 and 30 218493012421 outer membrane protein RatA; Provisional; Region: PRK15315 218493012422 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 218493012423 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012424 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012425 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012426 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 218493012427 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012428 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 218493012429 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012430 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 218493012431 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012432 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 218493012433 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 218493012446 1 probable transmembrane helix predicted for SBG2291 by TMHMM2.0 at aa 7-29 218493012447 signal peptide predicted for SBG2292 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 28 and 29 218493012448 intimin-like protein SinH; Provisional; Region: PRK15318 218493012449 1 probable transmembrane helix predicted for SBG2292 by TMHMM2.0 at aa 12-29 218493012450 signal peptide predicted for SBG2293 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.568 between residues 29 and 30 218493012451 intimin-like protein SinH; Provisional; Region: PRK15318 218493012452 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 218493012453 1 probable transmembrane helix predicted for SBG2293 by TMHMM2.0 at aa 7-29 218493012454 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 218493012456 GTP-binding protein Der; Reviewed; Region: PRK00093 218493012457 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 218493012458 G1 box; other site 218493012459 GTP/Mg2+ binding site [chemical binding]; other site 218493012460 Switch I region; other site 218493012461 G2 box; other site 218493012462 Switch II region; other site 218493012463 G3 box; other site 218493012464 G4 box; other site 218493012465 G5 box; other site 218493012466 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 218493012467 G1 box; other site 218493012468 GTP/Mg2+ binding site [chemical binding]; other site 218493012469 Switch I region; other site 218493012470 G2 box; other site 218493012471 G3 box; other site 218493012472 Switch II region; other site 218493012473 G4 box; other site 218493012474 G5 box; other site 218493012479 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 218493012480 signal peptide predicted for SBG2296 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.912 between residues 24 and 25 218493012481 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 218493012482 Trp docking motif [polypeptide binding]; other site 218493012488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 218493012489 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 218493012490 1 probable transmembrane helix predicted for SBG2297 by TMHMM2.0 at aa 24-43 218493012491 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 218493012492 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 218493012493 dimer interface [polypeptide binding]; other site 218493012494 motif 1; other site 218493012495 active site 218493012496 motif 2; other site 218493012497 motif 3; other site 218493012498 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 218493012499 anticodon binding site; other site 218493012503 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 218493012504 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 218493012505 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 218493012507 cytoskeletal protein RodZ; Provisional; Region: PRK10856 218493012508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493012509 non-specific DNA binding site [nucleotide binding]; other site 218493012510 salt bridge; other site 218493012511 sequence-specific DNA binding site [nucleotide binding]; other site 218493012512 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 218493012513 1 probable transmembrane helix predicted for SBG2300 by TMHMM2.0 at aa 111-133 218493012515 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 218493012516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493012517 FeS/SAM binding site; other site 218493012519 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 218493012520 active site 218493012521 multimer interface [polypeptide binding]; other site 218493012524 4Fe-4S binding domain; Region: Fer4; pfam00037 218493012525 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218493012526 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 218493012533 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 218493012534 8 probable transmembrane helices predicted for SBG2305 by TMHMM2.0 at aa 144-166, 179-201, 224-243,250-272, 287-309, 314-336, 361-380 and 387-406 218493012537 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 218493012538 4Fe-4S binding domain; Region: Fer4; pfam00037 218493012541 signal peptide predicted for SBG2306 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.478 between residues 48 and 49 218493012542 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 218493012543 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 218493012544 putative [Fe4-S4] binding site [ion binding]; other site 218493012545 putative molybdopterin cofactor binding site [chemical binding]; other site 218493012546 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 218493012547 putative molybdopterin cofactor binding site; other site 218493012553 signal peptide predicted for SBG2307 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.971 between residues 27 and 28 218493012554 penicillin-binding protein 1C; Provisional; Region: PRK11240 218493012555 Transglycosylase; Region: Transgly; pfam00912 218493012556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218493012557 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 218493012561 1 probable transmembrane helix predicted for SBG2307 by TMHMM2.0 at aa 12-34 218493012562 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 218493012563 signal peptide predicted for SBG2308 by SignalP 2.0 HMM (Signal peptide probabilty 0.902) with cleavage site probability 0.323 between residues 21 and 22 218493012564 MG2 domain; Region: A2M_N; pfam01835 218493012565 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 218493012566 surface patch; other site 218493012567 thioester region; other site 218493012568 specificity defining residues; other site 218493012572 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 218493012573 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 218493012574 active site residue [active] 218493012575 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 218493012576 active site residue [active] 218493012581 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 218493012583 aminopeptidase B; Provisional; Region: PRK05015 218493012584 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 218493012585 interface (dimer of trimers) [polypeptide binding]; other site 218493012586 Substrate-binding/catalytic site; other site 218493012587 Zn-binding sites [ion binding]; other site 218493012590 hypothetical protein; Provisional; Region: PRK10721 218493012592 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 218493012593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218493012594 catalytic loop [active] 218493012595 iron binding site [ion binding]; other site 218493012598 chaperone protein HscA; Provisional; Region: hscA; PRK05183 218493012599 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 218493012600 nucleotide binding site [chemical binding]; other site 218493012601 putative NEF/HSP70 interaction site [polypeptide binding]; other site 218493012602 SBD interface [polypeptide binding]; other site 218493012607 co-chaperone HscB; Provisional; Region: hscB; PRK05014 218493012608 DnaJ domain; Region: DnaJ; pfam00226 218493012609 HSP70 interaction site [polypeptide binding]; other site 218493012610 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 218493012613 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 218493012616 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 218493012617 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 218493012618 trimerization site [polypeptide binding]; other site 218493012619 active site 218493012621 cysteine desulfurase; Provisional; Region: PRK14012 218493012622 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 218493012623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218493012624 catalytic residue [active] 218493012627 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 218493012628 Rrf2 family protein; Region: rrf2_super; TIGR00738 218493012631 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 218493012632 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 218493012634 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218493012635 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 218493012636 active site 218493012637 dimerization interface [polypeptide binding]; other site 218493012642 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 218493012643 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493012647 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 218493012648 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 218493012649 FAD binding pocket [chemical binding]; other site 218493012650 FAD binding motif [chemical binding]; other site 218493012651 phosphate binding motif [ion binding]; other site 218493012652 beta-alpha-beta structure motif; other site 218493012653 NAD binding pocket [chemical binding]; other site 218493012654 Iron coordination center [ion binding]; other site 218493012657 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 218493012658 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218493012659 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493012666 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 218493012668 7 probable transmembrane helices predicted for SBG2325 by TMHMM2.0 at aa 13-35, 75-97, 110-132, 147-169,225-247, 251-273 and 294-316 218493012669 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 218493012670 signal peptide predicted for SBG2326 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 22 and 23 218493012672 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 218493012673 PRD domain; Region: PRD; pfam00874 218493012674 PRD domain; Region: PRD; pfam00874 218493012678 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 218493012679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493012680 putative substrate translocation pore; other site 218493012681 12 probable transmembrane helices predicted for SBG2328 by TMHMM2.0 at aa 9-31, 41-63, 70-92, 97-119,132-154, 158-180, 207-229, 234-256, 269-288, 293-315,328-350 and 354-371 218493012683 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 218493012684 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 218493012685 dimer interface [polypeptide binding]; other site 218493012686 active site 218493012687 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218493012688 folate binding site [chemical binding]; other site 218493012691 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 218493012692 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 218493012693 heme-binding site [chemical binding]; other site 218493012694 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 218493012695 FAD binding pocket [chemical binding]; other site 218493012696 FAD binding motif [chemical binding]; other site 218493012697 phosphate binding motif [ion binding]; other site 218493012698 beta-alpha-beta structure motif; other site 218493012699 NAD binding pocket [chemical binding]; other site 218493012700 Heme binding pocket [chemical binding]; other site 218493012704 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 218493012705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493012706 DNA binding site [nucleotide binding] 218493012708 1 probable transmembrane helix predicted for SBG2332 by TMHMM2.0 at aa 160-182 218493012709 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 218493012710 signal peptide predicted for SBG2333 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.273 between residues 26 and 27 218493012711 12 probable transmembrane helices predicted for SBG2333 by TMHMM2.0 at aa 7-29, 39-58, 93-115,120-142, 149-171, 186-208, 229-251, 271-293, 322-344,354-371, 384-403 and 407-424 218493012716 lysine decarboxylase CadA; Provisional; Region: PRK15400 218493012717 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218493012718 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218493012719 homodimer interface [polypeptide binding]; other site 218493012720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493012721 catalytic residue [active] 218493012722 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218493012727 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 218493012728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493012729 putative substrate translocation pore; other site 218493012730 POT family; Region: PTR2; pfam00854 218493012731 14 probable transmembrane helices predicted for SBG2335 by TMHMM2.0 at aa 9-31, 46-68, 71-93, 103-125,138-160, 164-186, 207-229, 234-251, 264-281, 309-331,338-360, 375-397, 404-426 and 454-476 218493012736 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 218493012737 Nitrogen regulatory protein P-II; Region: P-II; smart00938 218493012741 response regulator GlrR; Provisional; Region: PRK15115 218493012742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493012743 active site 218493012744 phosphorylation site [posttranslational modification] 218493012745 intermolecular recognition site; other site 218493012746 dimerization interface [polypeptide binding]; other site 218493012747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493012748 Walker A motif; other site 218493012749 ATP binding site [chemical binding]; other site 218493012750 Walker B motif; other site 218493012751 arginine finger; other site 218493012757 signal peptide predicted for SBG2338 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.706 between residues 41 and 42 218493012758 hypothetical protein; Provisional; Region: PRK10722 218493012760 signal peptide predicted for SBG2339 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.503 between residues 34 and 35 218493012761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218493012762 HAMP domain; Region: HAMP; pfam00672 218493012763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493012764 dimer interface [polypeptide binding]; other site 218493012765 phosphorylation site [posttranslational modification] 218493012766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493012767 ATP binding site [chemical binding]; other site 218493012768 Mg2+ binding site [ion binding]; other site 218493012769 G-X-G motif; other site 218493012773 2 probable transmembrane helices predicted for SBG2339 by TMHMM2.0 at aa 15-37 and 179-201 218493012774 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 218493012775 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 218493012776 dimerization interface [polypeptide binding]; other site 218493012777 ATP binding site [chemical binding]; other site 218493012778 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 218493012779 dimerization interface [polypeptide binding]; other site 218493012780 ATP binding site [chemical binding]; other site 218493012781 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 218493012782 putative active site [active] 218493012783 catalytic triad [active] 218493012788 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 218493012789 signal peptide predicted for SBG2341 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.503 between residues 37 and 38 218493012790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493012791 substrate binding pocket [chemical binding]; other site 218493012792 membrane-bound complex binding site; other site 218493012793 hinge residues; other site 218493012794 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493012795 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493012796 catalytic residue [active] 218493012797 1 probable transmembrane helix predicted for SBG2341 by TMHMM2.0 at aa 7-29 218493012800 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 218493012801 nucleoside/Zn binding site; other site 218493012802 dimer interface [polypeptide binding]; other site 218493012803 catalytic motif [active] 218493012806 hypothetical protein; Provisional; Region: PRK11590 218493012807 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 218493012808 1 probable transmembrane helix predicted for SBG2343 by TMHMM2.0 at aa 35-54 218493012809 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 218493012810 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493012811 active site turn [active] 218493012812 phosphorylation site [posttranslational modification] 218493012813 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218493012814 10 probable transmembrane helices predicted for SBG2344 by TMHMM2.0 at aa 118-140, 153-175, 190-212,219-236, 246-268, 288-310, 325-347, 360-382, 397-419 and 426-448 218493012818 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 218493012819 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 218493012820 putative active site [active] 218493012824 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218493012825 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 218493012826 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218493012827 putative active site [active] 218493012830 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 218493012833 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 218493012835 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 218493012836 active site 218493012837 hydrophilic channel; other site 218493012838 dimerization interface [polypeptide binding]; other site 218493012839 catalytic residues [active] 218493012840 active site lid [active] 218493012842 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 218493012843 Recombination protein O N terminal; Region: RecO_N; pfam11967 218493012844 Recombination protein O C terminal; Region: RecO_C; pfam02565 218493012846 GTPase Era; Reviewed; Region: era; PRK00089 218493012847 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 218493012848 G1 box; other site 218493012849 GTP/Mg2+ binding site [chemical binding]; other site 218493012850 Switch I region; other site 218493012851 G2 box; other site 218493012852 Switch II region; other site 218493012853 G3 box; other site 218493012854 G4 box; other site 218493012855 G5 box; other site 218493012856 KH domain; Region: KH_2; pfam07650 218493012860 ribonuclease III; Reviewed; Region: rnc; PRK00102 218493012861 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 218493012862 dimerization interface [polypeptide binding]; other site 218493012863 active site 218493012864 metal binding site [ion binding]; metal-binding site 218493012865 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 218493012866 dsRNA binding site [nucleotide binding]; other site 218493012870 signal peptidase I; Provisional; Region: PRK10861 218493012871 signal peptide predicted for SBG2353 by SignalP 2.0 HMM (Signal peptide probabilty 0.609) with cleavage site probability 0.472 between residues 38 and 39 218493012872 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218493012873 Catalytic site [active] 218493012874 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218493012879 2 probable transmembrane helices predicted for SBG2353 by TMHMM2.0 at aa 5-27 and 60-82 218493012880 GTP-binding protein LepA; Provisional; Region: PRK05433 218493012881 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 218493012882 G1 box; other site 218493012883 putative GEF interaction site [polypeptide binding]; other site 218493012884 GTP/Mg2+ binding site [chemical binding]; other site 218493012885 Switch I region; other site 218493012886 G2 box; other site 218493012887 G3 box; other site 218493012888 Switch II region; other site 218493012889 G4 box; other site 218493012890 G5 box; other site 218493012891 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 218493012892 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 218493012893 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 218493012900 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 218493012902 2 probable transmembrane helices predicted for SBG2355 by TMHMM2.0 at aa 61-83 and 87-104 218493012903 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 218493012904 anti-sigma E factor; Provisional; Region: rseB; PRK09455 218493012905 signal peptide predicted for SBG2356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 23 and 24 218493012907 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 218493012908 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 218493012909 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 218493012913 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 218493012914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218493012915 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218493012916 DNA binding residues [nucleotide binding] 218493012920 L-aspartate oxidase; Provisional; Region: PRK09077 218493012921 L-aspartate oxidase; Provisional; Region: PRK06175 218493012922 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218493012925 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 218493012926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493012927 S-adenosylmethionine binding site [chemical binding]; other site 218493012930 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 218493012931 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218493012932 ATP binding site [chemical binding]; other site 218493012933 Mg++ binding site [ion binding]; other site 218493012934 motif III; other site 218493012935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493012936 nucleotide binding region [chemical binding]; other site 218493012937 ATP-binding site [chemical binding]; other site 218493012942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493012943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493012944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218493012945 dimerization interface [polypeptide binding]; other site 218493012949 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 218493012950 6 probable transmembrane helices predicted for SBG2363 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 105-127,142-164 and 177-194 218493012952 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 218493012955 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 218493012956 ligand binding site [chemical binding]; other site 218493012957 active site 218493012958 UGI interface [polypeptide binding]; other site 218493012959 catalytic site [active] 218493012962 putative methyltransferase; Provisional; Region: PRK10864 218493012963 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 218493012964 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218493012967 thioredoxin 2; Provisional; Region: PRK10996 218493012968 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 218493012969 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218493012970 catalytic residues [active] 218493012973 Uncharacterized conserved protein [Function unknown]; Region: COG3148 218493012975 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 218493012976 CoA binding domain; Region: CoA_binding_2; pfam13380 218493012977 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 218493012978 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 218493012979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218493012980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 218493012983 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 218493012984 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 218493012985 domain interface [polypeptide binding]; other site 218493012986 putative active site [active] 218493012987 catalytic site [active] 218493012988 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 218493012989 domain interface [polypeptide binding]; other site 218493012990 putative active site [active] 218493012991 catalytic site [active] 218493012994 lipoprotein; Provisional; Region: PRK10759 218493012996 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 218493012997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493012998 putative substrate translocation pore; other site 218493013000 12 probable transmembrane helices predicted for SBG2372 by TMHMM2.0 at aa 21-43, 63-85, 97-114,119-141, 161-183, 198-215, 245-267, 282-304, 311-328,338-360, 373-395 and 405-424 218493013003 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 218493013004 protein disaggregation chaperone; Provisional; Region: PRK10865 218493013005 Clp amino terminal domain; Region: Clp_N; pfam02861 218493013006 Clp amino terminal domain; Region: Clp_N; pfam02861 218493013007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493013008 Walker A motif; other site 218493013009 ATP binding site [chemical binding]; other site 218493013010 Walker B motif; other site 218493013011 arginine finger; other site 218493013012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493013013 Walker A motif; other site 218493013014 ATP binding site [chemical binding]; other site 218493013015 Walker B motif; other site 218493013016 arginine finger; other site 218493013017 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218493013027 hypothetical protein; Provisional; Region: PRK10723 218493013028 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 218493013030 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 218493013031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493013032 RNA binding surface [nucleotide binding]; other site 218493013033 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218493013034 active site 218493013038 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 218493013039 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 218493013040 signal peptide predicted for SBG2377 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.417 between residues 23 and 24 218493013042 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 218493013043 30S subunit binding site; other site 218493013045 signal peptide predicted for SBG2381 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.639 between residues 22 and 23 218493013046 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 218493013047 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 218493013048 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 218493013049 Prephenate dehydratase; Region: PDT; pfam00800 218493013050 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 218493013051 putative L-Phe binding site [chemical binding]; other site 218493013055 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 218493013057 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 218493013058 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 218493013059 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 218493013060 prephenate dehydrogenase; Validated; Region: PRK08507 218493013063 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 218493013064 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218493013066 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 218493013067 signal peptide predicted for SBG2386 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.428 between residues 47 and 48 218493013068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493013069 metal binding site [ion binding]; metal-binding site 218493013070 active site 218493013071 I-site; other site 218493013072 2 probable transmembrane helices predicted for SBG2386 by TMHMM2.0 at aa 21-43 and 153-175 218493013076 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 218493013079 IS200 218493013080 Transposase IS200 like; Region: Y1_Tnp; pfam01797 218493013082 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 218493013085 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 218493013087 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 218493013088 RimM N-terminal domain; Region: RimM; pfam01782 218493013089 PRC-barrel domain; Region: PRC; pfam05239 218493013092 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 218493013095 signal recognition particle protein; Provisional; Region: PRK10867 218493013096 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 218493013097 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218493013098 P loop; other site 218493013099 GTP binding site [chemical binding]; other site 218493013100 Signal peptide binding domain; Region: SRP_SPB; pfam02978 218493013107 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 218493013108 signal peptide predicted for SBG2394 by SignalP 2.0 HMM (Signal peptide probabilty 0.861) with cleavage site probability 0.498 between residues 17 and 18 218493013109 8 probable transmembrane helices predicted for SBG2394 by TMHMM2.0 at aa 2-24, 34-56, 63-85, 90-109,129-151, 176-198, 210-227 and 237-254 218493013111 hypothetical protein; Provisional; Region: PRK11573 218493013112 Domain of unknown function DUF21; Region: DUF21; pfam01595 218493013113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218493013114 Transporter associated domain; Region: CorC_HlyC; smart01091 218493013116 3 probable transmembrane helices predicted for SBG2395 by TMHMM2.0 at aa 47-69, 79-97 and 109-131 218493013119 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 218493013120 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 218493013121 dimer interface [polypeptide binding]; other site 218493013122 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 218493013125 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 218493013126 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 218493013128 recombination and repair protein; Provisional; Region: PRK10869 218493013129 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 218493013130 Walker A/P-loop; other site 218493013131 ATP binding site [chemical binding]; other site 218493013132 Q-loop/lid; other site 218493013133 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 218493013134 ABC transporter signature motif; other site 218493013135 Walker B; other site 218493013136 D-loop; other site 218493013137 H-loop/switch region; other site 218493013140 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 218493013141 signal peptide predicted for SBG2399 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.469 between residues 22 and 23 218493013142 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 218493013147 hypothetical protein; Validated; Region: PRK01777 218493013149 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 218493013150 putative coenzyme Q binding site [chemical binding]; other site 218493013153 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 218493013154 SmpB-tmRNA interface; other site 218493013157 Salmonella pathogencity island 9. This region carries CDS which share a significant level of sequence identity with those carried on SPI-4 4105107..4129731 218493013158 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013159 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013160 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013161 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013162 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013163 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493013164 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013165 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013166 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013167 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013168 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013169 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493013170 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013171 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013172 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493013173 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013174 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493013175 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 218493013176 signal peptide predicted for SBG2404 by SignalP 2.0 HMM (Signal peptide probabilty 0.732) with cleavage site probability 0.625 between residues 22 and 23 218493013177 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218493013180 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 218493013181 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218493013182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493013183 Walker A/P-loop; other site 218493013184 ATP binding site [chemical binding]; other site 218493013185 Q-loop/lid; other site 218493013186 ABC transporter signature motif; other site 218493013187 Walker B; other site 218493013188 D-loop; other site 218493013189 H-loop/switch region; other site 218493013192 5 probable transmembrane helices predicted for SBG2405 by TMHMM2.0 at aa 168-190, 205-222, 281-303,307-324 and 389-411 218493013195 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218493013196 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493013197 1 probable transmembrane helix predicted for SBG2406 by TMHMM2.0 at aa 13-35 218493013201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 218493013203 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 218493013204 signal peptide predicted for SBG2408 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.555 between residues 44 and 45 218493013205 7 probable transmembrane helices predicted for SBG2408 by TMHMM2.0 at aa 10-32, 76-98, 118-140, 176-198,213-235, 256-278 and 305-327 218493013208 citrate uptake 218493013209 signal peptide predicted for SBG2409 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.570 between residues 39 and 40 218493013210 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 218493013211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218493013212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218493013213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493013214 dimer interface [polypeptide binding]; other site 218493013215 phosphorylation site [posttranslational modification] 218493013216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493013217 ATP binding site [chemical binding]; other site 218493013218 Mg2+ binding site [ion binding]; other site 218493013219 G-X-G motif; other site 218493013223 2 probable transmembrane helices predicted for SBG2409 by TMHMM2.0 at aa 15-37 and 170-192 218493013226 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 218493013227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493013228 active site 218493013229 phosphorylation site [posttranslational modification] 218493013230 intermolecular recognition site; other site 218493013231 dimerization interface [polypeptide binding]; other site 218493013232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493013233 DNA binding site [nucleotide binding] 218493013237 signal peptide predicted for SBG2411 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 22 and 23 218493013238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 218493013240 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 218493013241 signal peptide predicted for SBG2412 by SignalP 2.0 HMM (Signal peptide probabilty 0.778) with cleavage site probability 0.357 between residues 21 and 22 218493013242 4 probable transmembrane helices predicted for SBG2412 by TMHMM2.0 at aa 5-22, 37-55, 68-90 and 105-127 218493013243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 218493013245 12 probable transmembrane helices predicted for SBG2413 by TMHMM2.0 at aa 20-42, 47-69, 110-132,142-164, 171-193, 208-230, 260-282, 321-343, 356-378,388-410, 415-433 and 470-492 218493013247 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 218493013248 substrate binding pocket [chemical binding]; other site 218493013249 active site 218493013250 iron coordination sites [ion binding]; other site 218493013252 Predicted dehydrogenase [General function prediction only]; Region: COG0579 218493013253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218493013255 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 218493013256 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 218493013257 tetramerization interface [polypeptide binding]; other site 218493013258 NAD(P) binding site [chemical binding]; other site 218493013259 catalytic residues [active] 218493013263 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 218493013264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493013265 inhibitor-cofactor binding pocket; inhibition site 218493013266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493013267 catalytic residue [active] 218493013270 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 218493013272 12 probable transmembrane helices predicted for SBG2418 by TMHMM2.0 at aa 19-41, 46-65, 86-108,123-145, 152-174, 202-224, 245-267, 287-309, 335-357,362-381, 401-423 and 427-449 218493013275 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 218493013276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493013277 DNA-binding site [nucleotide binding]; DNA binding site 218493013278 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493013283 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 218493013284 bacterial OsmY and nodulation domain; Region: BON; smart00749 218493013285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493013288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493013289 dimerization interface [polypeptide binding]; other site 218493013290 signal peptide predicted for SBG2421 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 21 and 22 218493013291 putative DNA binding site [nucleotide binding]; other site 218493013292 Transcriptional regulators [Transcription]; Region: MarR; COG1846 218493013293 putative Zn2+ binding site [ion binding]; other site 218493013295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 218493013296 active site residue [active] 218493013297 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 218493013299 2 probable transmembrane helices predicted for SBG2422 by TMHMM2.0 at aa 117-139 and 143-165 218493013301 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 218493013302 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 218493013304 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 218493013306 4 probable transmembrane helices predicted for SBG2425 by TMHMM2.0 at aa 12-34, 44-62, 83-105 and 110-132 218493013307 hypothetical protein; Provisional; Region: PRK10556 218493013308 hypothetical protein; Provisional; Region: PRK10132 218493013310 1 probable transmembrane helix predicted for SBG2427 by TMHMM2.0 at aa 87-106 218493013311 The CDS represents the very 3' end of a deleted CDS 218493013312 this CDS is an orthologue of STY2928 and has been subject to a deletion event and a frameshift mutation 218493013313 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 218493013314 catalytic residues [active] 218493013317 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 218493013319 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 218493013320 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 218493013321 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218493013322 active site 218493013323 dimer interface [polypeptide binding]; other site 218493013324 catalytic residues [active] 218493013325 effector binding site; other site 218493013326 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 218493013331 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 218493013332 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218493013333 dimer interface [polypeptide binding]; other site 218493013334 putative radical transfer pathway; other site 218493013335 diiron center [ion binding]; other site 218493013336 tyrosyl radical; other site 218493013339 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 218493013340 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 218493013341 Walker A/P-loop; other site 218493013342 ATP binding site [chemical binding]; other site 218493013343 Q-loop/lid; other site 218493013344 ABC transporter signature motif; other site 218493013345 Walker B; other site 218493013346 D-loop; other site 218493013347 H-loop/switch region; other site 218493013348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 218493013353 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 218493013354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493013355 dimer interface [polypeptide binding]; other site 218493013356 conserved gate region; other site 218493013357 putative PBP binding loops; other site 218493013358 ABC-ATPase subunit interface; other site 218493013359 6 probable transmembrane helices predicted for SBG2435 by TMHMM2.0 at aa 94-116, 120-142, 149-171,197-219, 272-294 and 298-320 218493013362 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 218493013363 signal peptide predicted for SBG2436 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493013364 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 218493013367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218493013368 signal peptide predicted for SBG2437 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.914 between residues 25 and 26 218493013369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493013370 11 probable transmembrane helices predicted for SBG2437 by TMHMM2.0 at aa 7-29, 44-66, 78-95, 100-122,135-154, 164-186, 217-239, 249-271, 284-306, 338-360 and 365-387 218493013373 transcriptional repressor MprA; Provisional; Region: PRK10870 218493013374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218493013377 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 218493013378 signal peptide predicted for SBG2439 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.961 between residues 37 and 38 218493013379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493013380 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493013381 1 probable transmembrane helix predicted for SBG2439 by TMHMM2.0 at aa 23-45 218493013383 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 218493013384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493013385 putative substrate translocation pore; other site 218493013386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493013387 13 probable transmembrane helices predicted for SBG2440 by TMHMM2.0 at aa 13-35, 50-72, 79-96,106-128, 140-162, 167-189, 201-218, 228-250, 270-292,302-324, 336-353, 368-390 and 480-498 218493013390 S-ribosylhomocysteinase; Provisional; Region: PRK02260 218493013392 glutamate--cysteine ligase; Provisional; Region: PRK02107 218493013394 signal peptide predicted for SBG2444 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.564 between residues 18 and 19 218493013395 Predicted membrane protein [Function unknown]; Region: COG1238 218493013396 4 probable transmembrane helices predicted for SBG2444 by TMHMM2.0 at aa 15-37, 44-66, 86-108 and 115-137 218493013397 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 218493013398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493013399 motif II; other site 218493013401 carbon storage regulator; Provisional; Region: PRK01712 218493013403 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 218493013404 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 218493013405 motif 1; other site 218493013406 active site 218493013407 motif 2; other site 218493013408 motif 3; other site 218493013409 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 218493013410 DHHA1 domain; Region: DHHA1; pfam02272 218493013415 recombination regulator RecX; Reviewed; Region: recX; PRK00117 218493013417 recombinase A; Provisional; Region: recA; PRK09354 218493013418 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 218493013419 hexamer interface [polypeptide binding]; other site 218493013420 Walker A motif; other site 218493013421 ATP binding site [chemical binding]; other site 218493013422 Walker B motif; other site 218493013427 hypothetical protein; Validated; Region: PRK03661 218493013429 signal peptide predicted for SBG2451 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.694 between residues 21 and 22 218493013430 Transglycosylase SLT domain; Region: SLT_2; pfam13406 218493013431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493013432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493013434 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 218493013436 3 probable transmembrane helices predicted for SBG2452 by TMHMM2.0 at aa 26-48, 68-90 and 139-161 218493013438 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 218493013439 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 218493013440 Nucleoside recognition; Region: Gate; pfam07670 218493013441 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 218493013444 4 probable transmembrane helices predicted for SBG2453 by TMHMM2.0 at aa 181-203, 218-240, 247-269 and 300-322 218493013446 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 218493013448 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 218493013449 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 218493013450 putative NAD(P) binding site [chemical binding]; other site 218493013451 active site 218493013454 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 218493013455 signal peptide predicted for SBG2456 by SignalP 2.0 HMM (Signal peptide probabilty 0.632) with cleavage site probability 0.599 between residues 20 and 21 218493013457 1 probable transmembrane helix predicted for SBG2456 by TMHMM2.0 at aa 5-24 218493013458 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 218493013459 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218493013460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493013464 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 218493013465 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 218493013466 putative active site [active] 218493013467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 218493013470 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 218493013471 GAF domain; Region: GAF; pfam01590 218493013472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493013473 Walker A motif; other site 218493013474 ATP binding site [chemical binding]; other site 218493013475 Walker B motif; other site 218493013476 arginine finger; other site 218493013482 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 218493013483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218493013484 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 218493013485 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 218493013486 iron binding site [ion binding]; other site 218493013490 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 218493013491 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 218493013492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493013495 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 218493013496 Acylphosphatase; Region: Acylphosphatase; pfam00708 218493013497 HypF finger; Region: zf-HYPF; pfam07503 218493013498 HypF finger; Region: zf-HYPF; pfam07503 218493013499 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 218493013505 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 218493013506 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218493013512 hyc operon 218493013513 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 218493013514 nickel binding site [ion binding]; other site 218493013516 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 218493013518 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 218493013521 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 218493013522 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218493013527 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 218493013528 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 218493013529 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 218493013535 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 218493013536 NADH dehydrogenase; Region: NADHdh; cl00469 218493013538 7 probable transmembrane helices predicted for SBG2470 by TMHMM2.0 at aa 5-27, 62-84, 94-111, 132-154,169-188, 252-274 and 289-306 218493013542 signal peptide predicted for SBG2471 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.339 between residues 31 and 32 218493013543 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 218493013544 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218493013545 15 probable transmembrane helices predicted for SBG2471 by TMHMM2.0 at aa 4-26, 33-55, 79-96, 108-125,129-148, 155-177, 197-219, 231-253, 257-279, 292-311,326-348, 373-395, 415-437, 457-479 and 499-521 218493013548 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 218493013552 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 218493013553 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 218493013554 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 218493013557 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 218493013559 hydrogenase assembly chaperone; Provisional; Region: PRK10409 218493013562 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 218493013563 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 218493013565 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 218493013566 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 218493013567 dimerization interface [polypeptide binding]; other site 218493013568 ATP binding site [chemical binding]; other site 218493013571 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 218493013572 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218493013573 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218493013574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493013575 Walker A motif; other site 218493013576 ATP binding site [chemical binding]; other site 218493013577 Walker B motif; other site 218493013578 arginine finger; other site 218493013579 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218493013585 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 218493013586 Salmonella Pathogenicity Island 1. This island carries multiple virulence determinants for adhesion and entry into host cells 218493013587 signal peptide predicted for SBG2482 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 26 and 27 218493013588 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 218493013589 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 218493013590 metal binding site [ion binding]; metal-binding site 218493013591 1 probable transmembrane helix predicted for SBG2482 by TMHMM2.0 at aa 7-26 218493013593 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 218493013594 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218493013598 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218493013599 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493013600 ABC-ATPase subunit interface; other site 218493013601 dimer interface [polypeptide binding]; other site 218493013602 putative PBP binding regions; other site 218493013604 7 probable transmembrane helices predicted for SBG2484 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 127-149,182-204, 217-239 and 244-266 218493013606 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218493013607 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493013608 ABC-ATPase subunit interface; other site 218493013609 dimer interface [polypeptide binding]; other site 218493013610 putative PBP binding regions; other site 218493013612 8 probable transmembrane helices predicted for SBG2485 by TMHMM2.0 at aa 21-43, 53-75, 95-114, 129-151,171-193, 198-215, 222-244 and 249-266 218493013613 effector protein YopJ; Provisional; Region: PRK15371 218493013615 transcriptional activator SprB; Provisional; Region: PRK15320 218493013616 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 218493013617 transcriptional regulator SirC; Provisional; Region: PRK15044 218493013618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493013621 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 218493013622 invasion protein OrgB; Provisional; Region: PRK15322 218493013623 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 218493013624 invasion protein OrgA; Provisional; Region: PRK15323 218493013625 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 218493013626 1 probable transmembrane helix predicted for SBG2492 by TMHMM2.0 at aa 211-230 218493013629 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 218493013630 Type III secretion needle MxiH like; Region: MxiH; cl09641 218493013631 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 218493013632 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 218493013633 1 probable transmembrane helix predicted for SBG2495 by TMHMM2.0 at aa 141-163 218493013634 transcriptional regulator HilD; Provisional; Region: PRK15185 218493013635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493013639 invasion protein regulator; Provisional; Region: PRK12370 218493013640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493013641 DNA binding site [nucleotide binding] 218493013642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493013643 binding surface 218493013644 TPR motif; other site 218493013647 signal peptide predicted for SBG2498 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.997 between residues 19 and 20 218493013648 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 218493013649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493013650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493013651 catalytic residue [active] 218493013656 chaperone protein SicP; Provisional; Region: PRK15329 218493013658 putative acyl carrier protein IacP; Validated; Region: PRK08172 218493013660 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 218493013662 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 218493013664 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 218493013665 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 218493013667 2 probable transmembrane helices predicted for SBG2505 by TMHMM2.0 at aa 320-342 and 408-430 218493013668 chaperone protein SicA; Provisional; Region: PRK15331 218493013669 Tetratricopeptide repeat; Region: TPR_3; pfam07720 218493013670 Tetratricopeptide repeat; Region: TPR_3; pfam07720 218493013673 type III secretion system protein SpaS; Validated; Region: PRK08156 218493013675 3 probable transmembrane helices predicted for SBG2507 by TMHMM2.0 at aa 29-48, 73-95 and 178-200 218493013676 type III secretion system protein SpaR; Provisional; Region: PRK15332 218493013678 5 probable transmembrane helices predicted for SBG2508 by TMHMM2.0 at aa 12-34, 73-95, 128-150, 181-203 and 210-232 218493013679 type III secretion system protein SpaQ; Provisional; Region: PRK15333 218493013681 2 probable transmembrane helices predicted for SBG2509 by TMHMM2.0 at aa 12-34 and 49-71 218493013683 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 218493013684 signal peptide predicted for SBG2510 by SignalP 2.0 HMM (Signal peptide probabilty 0.953) with cleavage site probability 0.618 between residues 42 and 43 218493013687 3 probable transmembrane helices predicted for SBG2510 by TMHMM2.0 at aa 15-37, 50-69 and 161-183 218493013689 type III secretion system protein SpaO; Validated; Region: PRK08158 218493013690 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 218493013692 antigen presentation protein SpaN; Provisional; Region: PRK15334 218493013693 Surface presentation of antigens protein; Region: SPAN; pfam02510 218493013695 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 218493013697 ATP synthase SpaL; Validated; Region: PRK08149 218493013698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218493013699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218493013700 Walker A motif; other site 218493013701 ATP binding site [chemical binding]; other site 218493013702 Walker B motif; other site 218493013707 Invasion protein B family; Region: Invas_SpaK; cl04129 218493013709 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 218493013710 type III secretion system protein InvA; Provisional; Region: PRK15337 218493013711 signal peptide predicted for SBG2516 by SignalP 2.0 HMM (Signal peptide probabilty 0.679) with cleavage site probability 0.658 between residues 36 and 37 218493013713 8 probable transmembrane helices predicted for SBG2516 by TMHMM2.0 at aa 13-30, 35-57, 69-91, 106-128,197-219, 239-261, 274-291 and 296-315 218493013715 type III secretion system regulator InvE; Provisional; Region: PRK15338 218493013716 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 218493013718 signal peptide predicted for SBG2518 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.570 between residues 24 and 25 218493013719 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 218493013720 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218493013721 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218493013722 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218493013728 1 probable transmembrane helix predicted for SBG2518 by TMHMM2.0 at aa 5-24 218493013729 transcriptional regulator InvF; Provisional; Region: PRK15340 218493013732 InvH outer membrane lipoprotein; Region: InvH; pfam04741 218493013733 signal peptide predicted for SBG2520 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.892 between residues 31 and 32 218493013736 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 218493013737 MutS domain I; Region: MutS_I; pfam01624 218493013738 MutS domain II; Region: MutS_II; pfam05188 218493013739 MutS domain III; Region: MutS_III; pfam05192 218493013740 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 218493013741 Walker A/P-loop; other site 218493013742 ATP binding site [chemical binding]; other site 218493013743 Q-loop/lid; other site 218493013744 ABC transporter signature motif; other site 218493013745 Walker B; other site 218493013746 D-loop; other site 218493013747 H-loop/switch region; other site 218493013756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 218493013757 signal peptide predicted for SBG2525 by SignalP 2.0 HMM (Signal peptide probabilty 0.675) with cleavage site probability 0.306 between residues 33 and 34 218493013758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493013759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218493013760 putative substrate translocation pore; other site 218493013761 12 probable transmembrane helices predicted for SBG2525 by TMHMM2.0 at aa 7-29, 42-64, 73-92, 97-119,132-154, 159-181, 202-224, 239-257, 264-286, 291-313,334-356 and 366-388 218493013765 signal peptide predicted for SBG2526 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.400 between residues 30 and 31 218493013766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493013767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493013768 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218493013769 putative effector binding pocket; other site 218493013770 dimerization interface [polypeptide binding]; other site 218493013774 GntP family permease; Region: GntP_permease; pfam02447 218493013775 fructuronate transporter; Provisional; Region: PRK10034; cl15264 218493013776 13 probable transmembrane helices predicted for SBG2527 by TMHMM2.0 at aa 4-23, 30-48, 58-80, 104-126,176-198, 241-263, 278-300, 320-337, 352-369, 376-395,400-422, 435-456 and 466-485 218493013779 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218493013780 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 218493013781 putative NAD(P) binding site [chemical binding]; other site 218493013782 active site 218493013783 putative substrate binding site [chemical binding]; other site 218493013785 hypothetical protein; Provisional; Region: PRK09989 218493013787 putative aldolase; Validated; Region: PRK08130 218493013788 intersubunit interface [polypeptide binding]; other site 218493013789 active site 218493013790 Zn2+ binding site [ion binding]; other site 218493013793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 218493013795 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 218493013796 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218493013799 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493013800 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493013801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493013805 MarR family; Region: MarR_2; cl17246 218493013806 Transcriptional regulators [Transcription]; Region: MarR; COG1846 218493013808 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 218493013809 Flavoprotein; Region: Flavoprotein; pfam02441 218493013811 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 218493013813 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 218493013814 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218493013815 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218493013816 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218493013817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218493013818 DNA binding residues [nucleotide binding] 218493013825 signal peptide predicted for SBG2539 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.324 between residues 38 and 39 218493013826 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 218493013827 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493013828 Peptidase family M23; Region: Peptidase_M23; pfam01551 218493013832 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 218493013833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493013834 S-adenosylmethionine binding site [chemical binding]; other site 218493013838 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 218493013840 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 218493013841 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 218493013842 Permutation of conserved domain; other site 218493013843 active site 218493013844 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 218493013847 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 218493013848 homotrimer interaction site [polypeptide binding]; other site 218493013849 zinc binding site [ion binding]; other site 218493013850 CDP-binding sites; other site 218493013852 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 218493013853 substrate binding site; other site 218493013854 dimer interface; other site 218493013857 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 218493013858 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 218493013860 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 218493013861 3 probable transmembrane helices predicted for SBG2546 by TMHMM2.0 at aa 36-58, 63-85 and 95-117 218493013862 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 218493013863 ligand-binding site [chemical binding]; other site 218493013866 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 218493013867 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 218493013868 CysD dimerization site [polypeptide binding]; other site 218493013869 G1 box; other site 218493013870 putative GEF interaction site [polypeptide binding]; other site 218493013871 GTP/Mg2+ binding site [chemical binding]; other site 218493013872 Switch I region; other site 218493013873 G2 box; other site 218493013874 G3 box; other site 218493013875 Switch II region; other site 218493013876 G4 box; other site 218493013877 G5 box; other site 218493013878 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 218493013879 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 218493013884 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 218493013885 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218493013886 Active Sites [active] 218493013888 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 218493013889 signal peptide predicted for SBG2550 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 24 and 25 218493013890 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 218493013891 metal binding site [ion binding]; metal-binding site 218493013893 gtgttccccgcgccagcggggataaacc 218493013894 gtgttccccgcgccagcggggataaacc 218493013895 gtgttccccgcgccagcggggataaacc 218493013896 gtgttccccgcgccagcggggataaacc 218493013897 gtgttccccgcgccagcggggataaacc 218493013898 gtgttccccgcgccagcggggataaacc 218493013899 gtgttccccgcgccagcggggataaacc 218493013900 gtgttccccgcgccagcggggataaacc 218493013901 gtgttccccgcgccagcggggataaacc 218493013902 gtgttccccgcgccagcggggataaacc 218493013903 gtgttccccgcgccagcggggataaacc 218493013904 gtgttccccgcgccagcggggataaacc 218493013905 gtgttccccgcgccagcggggataaacc 218493013906 gtgttccccgcgccagcggggataaacc 218493013907 gtgttccccgcgccagcggggataaacc 218493013908 gtgttccccgcgccagcggggataaacc 218493013909 gtgttccccgcgccagcggggataaacc 218493013910 gtgttccccgcgccagcggggataaacc 218493013911 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 218493013912 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 218493013913 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 218493013915 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 218493013916 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 218493013917 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 218493013918 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 218493013919 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 218493013920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 218493013921 Salmonella outer protein D; Region: SopD; cl14701 218493013922 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 218493013923 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218493013924 Active Sites [active] 218493013926 sulfite reductase subunit beta; Provisional; Region: PRK13504 218493013927 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218493013928 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218493013933 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 218493013934 Flavodoxin; Region: Flavodoxin_1; pfam00258 218493013935 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 218493013936 FAD binding pocket [chemical binding]; other site 218493013937 FAD binding motif [chemical binding]; other site 218493013938 catalytic residues [active] 218493013939 NAD binding pocket [chemical binding]; other site 218493013940 phosphate binding motif [ion binding]; other site 218493013941 beta-alpha-beta structure motif; other site 218493013945 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 218493013946 active site 218493013948 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 218493013950 gtgttccccgcgccagcggggataaacc 218493013951 gtgttccccgcgccagcggggataaacc 218493013952 gtgttccccgcgccagcggggataaacc 218493013953 gtgttccccgcgccagcggggataaacc 218493013954 gtgttccccgcgccagcggggataaacc 218493013955 gtgttccccgcgccagcggggataaacc 218493013956 gtgttccccgcgccagcggggataaacc 218493013957 gtgttccccgcgccagcggggataaacc 218493013958 gtgttccccgcgccagcggggataaacc 218493013959 gtgttccccgcgccagcggggataaacc 218493013960 gtgttccccgcgccagcggggataaacc 218493013961 gtgttccccgcgccagcggggataaacc 218493013962 gtgttccccgcgccagcggggataaacc 218493013963 gtgttccccgcgccagcggggataaacc 218493013964 gtgttccccgcgccagcggggataaacc 218493013965 gtgttccccgcgccagcggggataaacc 218493013966 gtgttccccgcgccagcggggataaacc 218493013967 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 218493013968 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 218493013970 1 probable transmembrane helix predicted for SBG2567 by TMHMM2.0 at aa 20-42 218493013971 enolase; Provisional; Region: eno; PRK00077 218493013972 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 218493013973 dimer interface [polypeptide binding]; other site 218493013974 metal binding site [ion binding]; metal-binding site 218493013975 substrate binding pocket [chemical binding]; other site 218493013979 signal peptide predicted for SBG2569 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.901 between residues 26 and 27 218493013980 CTP synthetase; Validated; Region: pyrG; PRK05380 218493013981 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 218493013982 Catalytic site [active] 218493013983 active site 218493013984 UTP binding site [chemical binding]; other site 218493013985 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 218493013986 active site 218493013987 putative oxyanion hole; other site 218493013988 catalytic triad [active] 218493013992 1 probable transmembrane helix predicted for SBG2569 by TMHMM2.0 at aa 7-29 218493013993 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 218493013994 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 218493013995 homodimer interface [polypeptide binding]; other site 218493013996 metal binding site [ion binding]; metal-binding site 218493013997 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 218493013998 homodimer interface [polypeptide binding]; other site 218493013999 active site 218493014000 putative chemical substrate binding site [chemical binding]; other site 218493014001 metal binding site [ion binding]; metal-binding site 218493014004 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 218493014005 HD domain; Region: HD_4; pfam13328 218493014006 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218493014007 synthetase active site [active] 218493014008 NTP binding site [chemical binding]; other site 218493014009 metal binding site [ion binding]; metal-binding site 218493014010 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 218493014011 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218493014015 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 218493014016 TRAM domain; Region: TRAM; pfam01938 218493014017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493014018 S-adenosylmethionine binding site [chemical binding]; other site 218493014023 Carries a frameshift mutation follwoing codon 377 218493014024 signal peptide predicted for SBG2573 by SignalP 2.0 HMM (Signal peptide probabilty 0.812) with cleavage site probability 0.744 between residues 33 and 34 218493014025 2 probable transmembrane helices predicted for SBG2573 by TMHMM2.0 at aa 10-32 and 177-199 218493014031 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 218493014033 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 218493014034 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 218493014035 active site 218493014036 tetramer interface [polypeptide binding]; other site 218493014039 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 218493014040 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 218493014041 active site 218493014042 tetramer interface [polypeptide binding]; other site 218493014045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014046 D-galactonate transporter; Region: 2A0114; TIGR00893 218493014047 putative substrate translocation pore; other site 218493014048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014049 12 probable transmembrane helices predicted for SBG2578 by TMHMM2.0 at aa 20-42, 57-79, 86-105,110-132, 152-174, 179-201, 255-277, 287-309, 329-348,352-374, 387-409 and 414-436 218493014052 flavodoxin; Provisional; Region: PRK08105 218493014054 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218493014055 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 218493014056 probable active site [active] 218493014059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 218493014061 SecY interacting protein Syd; Provisional; Region: PRK04968 218493014063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 218493014064 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 218493014065 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 218493014067 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 218493014068 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 218493014070 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493014071 serine transporter; Region: stp; TIGR00814 218493014072 11 probable transmembrane helices predicted for SBG2585 by TMHMM2.0 at aa 24-41, 45-67, 103-125,140-157, 164-186, 206-228, 249-271, 300-322, 351-373,377-394 and 406-428 218493014074 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 218493014075 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218493014076 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218493014079 flap endonuclease-like protein; Provisional; Region: PRK09482 218493014080 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218493014081 active site 218493014082 metal binding site 1 [ion binding]; metal-binding site 218493014083 putative 5' ssDNA interaction site; other site 218493014084 metal binding site 3; metal-binding site 218493014085 metal binding site 2 [ion binding]; metal-binding site 218493014086 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218493014087 putative DNA binding site [nucleotide binding]; other site 218493014088 putative metal binding site [ion binding]; other site 218493014091 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 218493014092 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 218493014094 hypothetical protein; Provisional; Region: PRK10873 218493014095 signal peptide predicted for SBG2589 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.399 between residues 27 and 28 218493014096 4 probable transmembrane helices predicted for SBG2589 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 98-120 218493014098 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 218493014099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014100 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 218493014101 dimerization interface [polypeptide binding]; other site 218493014102 substrate binding pocket [chemical binding]; other site 218493014106 signal peptide predicted for SBG2591 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.643 between residues 19 and 20 218493014107 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493014109 1 probable transmembrane helix predicted for SBG2591 by TMHMM2.0 at aa 5-27 218493014111 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 218493014112 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218493014113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218493014114 catalytic residue [active] 218493014118 CsdA-binding activator; Provisional; Region: PRK15019 218493014120 Predicted permeases [General function prediction only]; Region: RarD; COG2962 218493014121 10 probable transmembrane helices predicted for SBG2594 by TMHMM2.0 at aa 7-29, 34-56, 72-93, 97-119,124-146, 150-167, 174-196, 206-228, 235-257 and 262-284 218493014124 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 218493014125 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 218493014126 putative ATP binding site [chemical binding]; other site 218493014127 putative substrate interface [chemical binding]; other site 218493014128 1 probable transmembrane helix predicted for SBG2595 by TMHMM2.0 at aa 235-257 218493014130 murein transglycosylase A; Provisional; Region: mltA; PRK11162 218493014131 signal peptide predicted for SBG2596 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.646 between residues 23 and 24 218493014132 murein hydrolase B; Provisional; Region: PRK10760; cl17906 218493014133 MltA specific insert domain; Region: MltA; pfam03562 218493014134 3D domain; Region: 3D; pfam06725 218493014138 signal peptide predicted for SBG2597 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.950 between residues 31 and 32 218493014139 AMIN domain; Region: AMIN; pfam11741 218493014140 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 218493014141 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218493014142 active site 218493014143 metal binding site [ion binding]; metal-binding site 218493014145 N-acetylglutamate synthase; Validated; Region: PRK05279 218493014146 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 218493014147 putative feedback inhibition sensing region; other site 218493014148 putative nucleotide binding site [chemical binding]; other site 218493014149 putative substrate binding site [chemical binding]; other site 218493014150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493014151 Coenzyme A binding pocket [chemical binding]; other site 218493014154 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 218493014155 AAA domain; Region: AAA_30; pfam13604 218493014156 Family description; Region: UvrD_C_2; pfam13538 218493014158 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 218493014162 protease3; Provisional; Region: PRK15101 218493014163 signal peptide predicted for SBG2601 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.934 between residues 23 and 24 218493014164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218493014165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218493014166 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218493014171 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 218493014172 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 218493014174 hypothetical protein; Provisional; Region: PRK10332 218493014175 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 218493014176 1 probable transmembrane helix predicted for SBG2603 by TMHMM2.0 at aa 15-37 218493014179 hypothetical protein; Provisional; Region: PRK10557 218493014180 signal peptide predicted for SBG2604 by SignalP 2.0 HMM (Signal peptide probabilty 0.679) with cleavage site probability 0.445 between residues 35 and 36 218493014181 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 218493014184 1 probable transmembrane helix predicted for SBG2604 by TMHMM2.0 at aa 7-26 218493014185 hypothetical protein; Provisional; Region: PRK10506 218493014186 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 218493014187 1 probable transmembrane helix predicted for SBG2605 by TMHMM2.0 at aa 7-29 218493014189 thymidylate synthase; Reviewed; Region: thyA; PRK01827 218493014190 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 218493014191 dimerization interface [polypeptide binding]; other site 218493014192 active site 218493014195 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 218493014197 5 probable transmembrane helices predicted for SBG2607 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282 218493014199 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 218493014200 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218493014201 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218493014202 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218493014203 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218493014210 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 218493014211 putative active site [active] 218493014212 Ap4A binding site [chemical binding]; other site 218493014213 nudix motif; other site 218493014214 putative metal binding site [ion binding]; other site 218493014217 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 218493014218 putative DNA-binding cleft [nucleotide binding]; other site 218493014219 putative DNA clevage site; other site 218493014220 molecular lever; other site 218493014222 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218493014224 7 probable transmembrane helices predicted for SBG2611 by TMHMM2.0 at aa 15-37, 50-69, 84-101, 122-139,154-176, 183-202 and 212-230 218493014225 signal peptide predicted for SBG2612 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.658 between residues 19 and 20 218493014226 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218493014228 1 probable transmembrane helix predicted for SBG2612 by TMHMM2.0 at aa 4-26 218493014230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493014231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493014232 active site 218493014233 catalytic tetrad [active] 218493014235 signal peptide predicted for SBG2614 by SignalP 2.0 HMM (Signal peptide probabilty 0.677) with cleavage site probability 0.637 between residues 29 and 30 218493014236 lysophospholipid transporter LplT; Provisional; Region: PRK11195 218493014237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014238 12 probable transmembrane helices predicted for SBG2614 by TMHMM2.0 at aa 19-41, 51-73, 94-116,136-158, 163-185, 195-213, 220-242, 257-279, 286-305,309-331, 344-366 and 371-393 218493014240 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 218493014241 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218493014242 putative acyl-acceptor binding pocket; other site 218493014243 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 218493014244 acyl-activating enzyme (AAE) consensus motif; other site 218493014245 putative AMP binding site [chemical binding]; other site 218493014249 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 218493014250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493014251 DNA binding site [nucleotide binding] 218493014252 domain linker motif; other site 218493014253 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218493014254 dimerization interface (closed form) [polypeptide binding]; other site 218493014255 ligand binding site [chemical binding]; other site 218493014259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493014260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493014261 DNA binding site [nucleotide binding] 218493014262 domain linker motif; other site 218493014263 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218493014264 dimerization interface (closed form) [polypeptide binding]; other site 218493014265 ligand binding site [chemical binding]; other site 218493014268 diaminopimelate decarboxylase; Provisional; Region: PRK11165 218493014269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 218493014270 active site 218493014271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218493014272 substrate binding site [chemical binding]; other site 218493014273 catalytic residues [active] 218493014274 dimer interface [polypeptide binding]; other site 218493014279 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 218493014280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014281 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 218493014282 putative dimerization interface [polypeptide binding]; other site 218493014286 putative racemase; Provisional; Region: PRK10200 218493014287 aspartate racemase; Region: asp_race; TIGR00035 218493014292 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 218493014293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014294 putative substrate translocation pore; other site 218493014295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014297 12 probable transmembrane helices predicted for SBG2621 by TMHMM2.0 at aa 24-46, 61-83, 90-112,116-138, 150-167, 177-199, 259-281, 296-318, 325-347,362-384, 397-419 and 424-446 218493014300 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 218493014301 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 218493014302 NADP binding site [chemical binding]; other site 218493014303 homodimer interface [polypeptide binding]; other site 218493014304 active site 218493014307 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 218493014309 putative acyltransferase; Provisional; Region: PRK05790 218493014310 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218493014311 dimer interface [polypeptide binding]; other site 218493014312 active site 218493014319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493014320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218493014322 dimerization interface [polypeptide binding]; other site 218493014325 Predicted membrane protein [Function unknown]; Region: COG4125 218493014326 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 218493014327 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 218493014329 4 probable transmembrane helices predicted for SBG2626 by TMHMM2.0 at aa 13-35, 40-62, 83-105 and 115-134 218493014331 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493014332 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 218493014333 10 probable transmembrane helices predicted for SBG2627 by TMHMM2.0 at aa 20-42, 86-108, 123-145,152-174, 194-216, 236-258, 287-309, 334-356, 360-382 and 389-408 218493014335 Partial SPI-3 region 218493014336 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 218493014337 DNA binding site [nucleotide binding] 218493014339 signal peptide predicted for SBG2629 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.741 between residues 21 and 22 218493014340 1 probable transmembrane helix predicted for SBG2629 by TMHMM2.0 at aa 7-26 218493014342 autotransport protein MisL; Provisional; Region: PRK15313 218493014343 signal peptide predicted for SBG2630 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.878 between residues 27 and 28 218493014344 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 218493014345 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218493014348 1 probable transmembrane helix predicted for SBG2630 by TMHMM2.0 at aa 7-29 218493014350 signal peptide predicted for SBG2632 by SignalP 2.0 HMM (Signal peptide probabilty 0.940) with cleavage site probability 0.388 between residues 31 and 32 218493014351 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 218493014352 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218493014353 Peptidase family M23; Region: Peptidase_M23; pfam01551 218493014357 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 218493014358 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 218493014359 active site 218493014360 metal binding site [ion binding]; metal-binding site 218493014361 nudix motif; other site 218493014364 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 218493014365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 218493014366 dimer interface [polypeptide binding]; other site 218493014367 putative anticodon binding site; other site 218493014368 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 218493014369 motif 1; other site 218493014370 active site 218493014371 motif 2; other site 218493014372 motif 3; other site 218493014377 This domain is found in peptide chain release factors; Region: PCRF; smart00937 218493014378 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 218493014379 RF-1 domain; Region: RF-1; pfam00472 218493014383 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 218493014384 DHH family; Region: DHH; pfam01368 218493014385 DHHA1 domain; Region: DHHA1; pfam02272 218493014388 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 218493014389 signal peptide predicted for SBG2637 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22 218493014390 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 218493014391 dimerization domain [polypeptide binding]; other site 218493014392 dimer interface [polypeptide binding]; other site 218493014393 catalytic residues [active] 218493014396 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 218493014397 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 218493014398 active site 218493014399 Int/Topo IB signature motif; other site 218493014402 flavodoxin FldB; Provisional; Region: PRK12359 218493014405 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 218493014407 1 probable transmembrane helix predicted for SBG2640 by TMHMM2.0 at aa 10-32 218493014408 hypothetical protein; Provisional; Region: PRK10878 218493014410 putative global regulator; Reviewed; Region: PRK09559 218493014411 GDYXXLXY protein; Region: GDYXXLXY; cl02066 218493014412 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 218493014413 hemolysin; Provisional; Region: PRK15087 218493014414 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 218493014415 7 probable transmembrane helices predicted for SBG2643 by TMHMM2.0 at aa 20-42, 52-74, 87-106, 111-133,138-160, 164-186 and 193-215 218493014417 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 218493014419 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 218493014420 beta-galactosidase; Region: BGL; TIGR03356 218493014424 glycine dehydrogenase; Provisional; Region: PRK05367 218493014425 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 218493014426 tetramer interface [polypeptide binding]; other site 218493014427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493014428 catalytic residue [active] 218493014429 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 218493014430 tetramer interface [polypeptide binding]; other site 218493014431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493014432 catalytic residue [active] 218493014435 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 218493014436 lipoyl attachment site [posttranslational modification]; other site 218493014439 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 218493014440 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 218493014443 oxidoreductase; Provisional; Region: PRK08013 218493014444 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 218493014449 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 218493014450 signal peptide predicted for SBG2650 by SignalP 2.0 HMM (Signal peptide probabilty 0.925) with cleavage site probability 0.724 between residues 25 and 26 218493014451 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 218493014454 proline aminopeptidase P II; Provisional; Region: PRK10879 218493014455 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 218493014456 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 218493014457 active site 218493014461 hypothetical protein; Reviewed; Region: PRK01736 218493014463 Z-ring-associated protein; Provisional; Region: PRK10972 218493014465 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 218493014466 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 218493014468 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 218493014469 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 218493014470 ligand binding site [chemical binding]; other site 218493014471 NAD binding site [chemical binding]; other site 218493014472 tetramer interface [polypeptide binding]; other site 218493014473 catalytic site [active] 218493014474 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 218493014475 L-serine binding site [chemical binding]; other site 218493014476 ACT domain interface; other site 218493014483 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 218493014484 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218493014485 active site 218493014486 dimer interface [polypeptide binding]; other site 218493014488 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 218493014489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014490 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 218493014491 putative dimerization interface [polypeptide binding]; other site 218493014495 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 218493014496 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 218493014497 active site 218493014498 substrate binding site [chemical binding]; other site 218493014499 coenzyme B12 binding site [chemical binding]; other site 218493014500 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 218493014501 B12 binding site [chemical binding]; other site 218493014502 cobalt ligand [ion binding]; other site 218493014506 membrane ATPase/protein kinase; Provisional; Region: PRK09435 218493014507 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 218493014508 Walker A; other site 218493014512 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 218493014513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218493014514 substrate binding site [chemical binding]; other site 218493014515 oxyanion hole (OAH) forming residues; other site 218493014516 trimer interface [polypeptide binding]; other site 218493014519 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 218493014520 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 218493014521 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 218493014523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493014525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218493014526 dimerization interface [polypeptide binding]; other site 218493014530 Uncharacterized conserved protein [Function unknown]; Region: COG2968 218493014531 signal peptide predicted for SBG2663 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 21 and 22 218493014532 oxidative stress defense protein; Provisional; Region: PRK11087 218493014534 arginine exporter protein; Provisional; Region: PRK09304 218493014535 signal peptide predicted for SBG2664 by SignalP 2.0 HMM (Signal peptide probabilty 0.941) with cleavage site probability 0.900 between residues 26 and 27 218493014537 6 probable transmembrane helices predicted for SBG2664 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133,148-170 and 182-199 218493014538 mechanosensitive channel MscS; Provisional; Region: PRK10334 218493014539 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493014542 3 probable transmembrane helices predicted for SBG2665 by TMHMM2.0 at aa 23-45, 65-87 and 102-124 218493014544 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 218493014545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493014546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493014547 dimerization interface [polypeptide binding]; other site 218493014550 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 218493014551 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 218493014553 membrane protein FdrA; Validated; Region: PRK06091 218493014554 CoA binding domain; Region: CoA_binding; pfam02629 218493014555 CoA-ligase; Region: Ligase_CoA; pfam00549 218493014558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014559 D-galactonate transporter; Region: 2A0114; TIGR00893 218493014560 putative substrate translocation pore; other site 218493014561 11 probable transmembrane helices predicted for SBG2670 by TMHMM2.0 at aa 15-34, 51-73, 88-110,148-170, 180-198, 226-248, 258-280, 293-312, 317-339,352-374 and 384-402 218493014564 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 218493014565 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 218493014566 putative substrate binding site [chemical binding]; other site 218493014567 nucleotide binding site [chemical binding]; other site 218493014568 nucleotide binding site [chemical binding]; other site 218493014569 homodimer interface [polypeptide binding]; other site 218493014571 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 218493014572 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 218493014573 active site 218493014574 intersubunit interface [polypeptide binding]; other site 218493014575 zinc binding site [ion binding]; other site 218493014576 Na+ binding site [ion binding]; other site 218493014580 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 218493014581 Phosphoglycerate kinase; Region: PGK; pfam00162 218493014582 substrate binding site [chemical binding]; other site 218493014583 hinge regions; other site 218493014584 ADP binding site [chemical binding]; other site 218493014585 catalytic site [active] 218493014588 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 218493014589 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 218493014590 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218493014594 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 218493014595 trimer interface [polypeptide binding]; other site 218493014596 putative Zn binding site [ion binding]; other site 218493014600 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 218493014601 hypothetical protein; Provisional; Region: PRK09609 218493014602 5 probable transmembrane helices predicted for SBG2676 by TMHMM2.0 at aa 10-32, 39-61, 71-90, 103-125 and 152-174 218493014603 signal peptide predicted for SBG2677 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.225 between residues 22 and 23 218493014604 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 218493014607 4 probable transmembrane helices predicted for SBG2677 by TMHMM2.0 at aa 18-40, 47-69, 84-103 and 116-135 218493014608 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218493014609 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 218493014610 Walker A/P-loop; other site 218493014611 ATP binding site [chemical binding]; other site 218493014612 Q-loop/lid; other site 218493014613 ABC transporter signature motif; other site 218493014614 Walker B; other site 218493014615 D-loop; other site 218493014618 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218493014619 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 218493014620 Walker A/P-loop; other site 218493014621 ATP binding site [chemical binding]; other site 218493014622 Q-loop/lid; other site 218493014623 ABC transporter signature motif; other site 218493014624 Walker B; other site 218493014625 D-loop; other site 218493014626 H-loop/switch region; other site 218493014629 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 218493014630 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 218493014631 active site 218493014634 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 218493014635 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 218493014637 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 218493014638 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 218493014639 putative active site [active] 218493014641 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 218493014642 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218493014643 putative NAD(P) binding site [chemical binding]; other site 218493014644 catalytic Zn binding site [ion binding]; other site 218493014647 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 218493014648 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 218493014649 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 218493014650 active site 218493014651 P-loop; other site 218493014652 phosphorylation site [posttranslational modification] 218493014654 8 probable transmembrane helices predicted for SBG2684 by TMHMM2.0 at aa 21-43, 53-75, 82-104, 136-158,214-236, 246-264, 271-293 and 313-335 218493014656 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493014657 active site 218493014658 phosphorylation site [posttranslational modification] 218493014660 transketolase; Reviewed; Region: PRK12753 218493014661 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218493014662 TPP-binding site [chemical binding]; other site 218493014663 dimer interface [polypeptide binding]; other site 218493014664 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218493014665 PYR/PP interface [polypeptide binding]; other site 218493014666 dimer interface [polypeptide binding]; other site 218493014667 TPP binding site [chemical binding]; other site 218493014668 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218493014674 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 218493014675 signal peptide predicted for SBG2687 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.264 between residues 34 and 35 218493014678 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 218493014679 agmatinase; Region: agmatinase; TIGR01230 218493014680 oligomer interface [polypeptide binding]; other site 218493014681 putative active site [active] 218493014682 Mn binding site [ion binding]; other site 218493014687 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 218493014688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 218493014689 dimer interface [polypeptide binding]; other site 218493014690 active site 218493014691 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218493014692 catalytic residues [active] 218493014693 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 218493014698 S-adenosylmethionine synthetase; Validated; Region: PRK05250 218493014699 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 218493014700 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 218493014701 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 218493014707 signal peptide predicted for SBG2691 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.640 between residues 30 and 31 218493014708 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 218493014709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014710 putative substrate translocation pore; other site 218493014711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014712 12 probable transmembrane helices predicted for SBG2691 by TMHMM2.0 at aa 13-35, 55-77, 84-103,108-130, 142-159, 169-191, 252-274, 289-311, 318-340,350-372, 385-407 and 417-436 218493014716 hypothetical protein; Provisional; Region: PRK04860 218493014717 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 218493014720 DNA-specific endonuclease I; Provisional; Region: PRK15137 218493014721 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 218493014722 signal peptide predicted for SBG2693 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23 218493014724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 218493014725 RNA methyltransferase, RsmE family; Region: TIGR00046 218493014728 glutathione synthetase; Provisional; Region: PRK05246 218493014729 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 218493014730 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 218493014734 hypothetical protein; Validated; Region: PRK00228 218493014736 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 218493014738 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 218493014739 Transcriptional regulator [Transcription]; Region: IclR; COG1414 218493014741 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 218493014742 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 218493014743 Walker A motif; other site 218493014744 ATP binding site [chemical binding]; other site 218493014745 Walker B motif; other site 218493014749 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 218493014750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218493014751 catalytic residue [active] 218493014754 YGGT family; Region: YGGT; pfam02325 218493014755 YGGT family; Region: YGGT; pfam02325 218493014757 4 probable transmembrane helices predicted for SBG2701 by TMHMM2.0 at aa 5-24, 63-85, 89-111 and 153-175 218493014759 hypothetical protein; Validated; Region: PRK05090 218493014761 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 218493014762 active site 218493014763 dimerization interface [polypeptide binding]; other site 218493014765 HemN family oxidoreductase; Provisional; Region: PRK05660 218493014766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493014767 FeS/SAM binding site; other site 218493014768 HemN C-terminal domain; Region: HemN_C; pfam06969 218493014771 signal peptide predicted for SBG2705 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493014772 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 218493014773 homodimer interface [polypeptide binding]; other site 218493014774 active site 218493014778 1 probable transmembrane helix predicted for SBG2705 by TMHMM2.0 at aa 7-29 218493014779 hypothetical protein; Provisional; Region: PRK10626 218493014780 signal peptide predicted for SBG2706 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.851 between residues 20 and 21 218493014781 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 218493014782 hypothetical protein; Provisional; Region: PRK11702 218493014784 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 218493014786 adenine DNA glycosylase; Provisional; Region: PRK10880 218493014787 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218493014788 minor groove reading motif; other site 218493014789 helix-hairpin-helix signature motif; other site 218493014790 substrate binding pocket [chemical binding]; other site 218493014791 active site 218493014792 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 218493014793 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 218493014794 DNA binding and oxoG recognition site [nucleotide binding] 218493014799 oxidative damage protection protein; Provisional; Region: PRK05408 218493014801 signal peptide predicted for SBG2711 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.630 between residues 23 and 24 218493014802 murein transglycosylase C; Provisional; Region: mltC; PRK11671 218493014803 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 218493014804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493014805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493014806 catalytic residue [active] 218493014810 nucleoside transporter; Region: 2A0110; TIGR00889 218493014812 12 probable transmembrane helices predicted for SBG2712 by TMHMM2.0 at aa 9-31, 41-63, 70-87, 92-114,135-152, 162-184, 211-233, 253-275, 282-301, 311-333,346-365 and 380-402 218493014814 ornithine decarboxylase; Provisional; Region: PRK13578 218493014815 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218493014816 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218493014817 homodimer interface [polypeptide binding]; other site 218493014818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493014819 catalytic residue [active] 218493014820 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218493014825 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 218493014827 6 probable transmembrane helices predicted for SBG2714 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167,177-199 and 211-233 218493014830 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218493014831 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218493014832 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218493014833 1 probable transmembrane helix predicted for SBG2715 by TMHMM2.0 at aa 5-27 218493014837 conserved hypothetical protein; Region: TIGR02270 218493014838 conserved hypothetical protein; Region: TIGR02270 218493014839 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 218493014840 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 218493014841 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493014842 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493014843 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 218493014845 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 218493014846 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 218493014848 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493014849 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 218493014850 The predicted amino acid sequence of this defunct CDS shares 95.092% identity in 163 aa overlap with a region within the upstream CDS SBG2715 218493014851 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 218493014852 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 218493014853 active site 218493014854 catalytic site [active] 218493014855 Zn binding site [ion binding]; other site 218493014856 tetramer interface [polypeptide binding]; other site 218493014858 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 218493014859 Predicted amidohydrolase [General function prediction only]; Region: COG0388 218493014860 active site 218493014861 catalytic triad [active] 218493014862 dimer interface [polypeptide binding]; other site 218493014865 signal peptide predicted for SBG2730 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.628 between residues 31 and 32 218493014866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493014867 D-galactonate transporter; Region: 2A0114; TIGR00893 218493014868 putative substrate translocation pore; other site 218493014869 9 probable transmembrane helices predicted for SBG2730 by TMHMM2.0 at aa 7-29, 75-97, 137-159, 169-191,236-258, 268-290, 311-333, 362-384 and 391-413 218493014871 mannonate dehydratase; Provisional; Region: PRK03906 218493014872 mannonate dehydratase; Region: uxuA; TIGR00695 218493014874 D-mannonate oxidoreductase; Provisional; Region: PRK15037 218493014875 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218493014876 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218493014881 Glucuronate isomerase; Region: UxaC; pfam02614 218493014882 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 218493014884 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 218493014886 2 probable transmembrane helices predicted for SBG2734 by TMHMM2.0 at aa 4-26 and 39-61 218493014887 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 218493014888 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 218493014889 active site 218493014891 putative symporter YagG; Provisional; Region: PRK09669 218493014892 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218493014893 12 probable transmembrane helices predicted for SBG2736 by TMHMM2.0 at aa 13-35, 40-62, 83-100,110-132, 153-171, 181-203, 234-256, 276-297, 304-323,327-345, 377-399 and 414-436 218493014896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493014897 dimer interface [polypeptide binding]; other site 218493014898 putative CheW interface [polypeptide binding]; other site 218493014899 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 218493014901 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 218493014902 CHAP domain; Region: CHAP; pfam05257 218493014903 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 218493014906 1 probable transmembrane helix predicted for SBG2738 by TMHMM2.0 at aa 66-85 218493014907 putative S-transferase; Provisional; Region: PRK11752 218493014908 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 218493014909 C-terminal domain interface [polypeptide binding]; other site 218493014910 GSH binding site (G-site) [chemical binding]; other site 218493014911 dimer interface [polypeptide binding]; other site 218493014912 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 218493014913 dimer interface [polypeptide binding]; other site 218493014914 N-terminal domain interface [polypeptide binding]; other site 218493014915 active site 218493014919 hydrogenase-2 biosynthetic operon 218493014920 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 218493014923 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 218493014924 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 218493014929 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 218493014930 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 218493014931 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 218493014932 putative substrate-binding site; other site 218493014933 nickel binding site [ion binding]; other site 218493014935 hydrogenase 2 large subunit; Provisional; Region: PRK10467 218493014936 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 218493014940 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 218493014941 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 218493014942 10 probable transmembrane helices predicted for SBG2746 by TMHMM2.0 at aa 17-39, 54-76, 89-111,131-153, 166-185, 205-227, 248-270, 285-307, 314-336 and 351-373 218493014945 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 218493014946 signal peptide predicted for SBG2747 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 26 and 27 218493014947 4Fe-4S binding domain; Region: Fer4_6; pfam12837 218493014950 hydrogenase 2 small subunit; Provisional; Region: PRK10468 218493014951 signal peptide predicted for SBG2748 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.739 between residues 37 and 38 218493014952 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 218493014953 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 218493014954 1 probable transmembrane helix predicted for SBG2748 by TMHMM2.0 at aa 332-354 218493014958 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 218493014959 signal peptide predicted for SBG2750 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.716 between residues 36 and 37 218493014960 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 218493014961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493014962 dimerization interface [polypeptide binding]; other site 218493014963 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493014964 dimer interface [polypeptide binding]; other site 218493014965 putative CheW interface [polypeptide binding]; other site 218493014969 2 probable transmembrane helices predicted for SBG2750 by TMHMM2.0 at aa 10-32 and 190-212 218493014970 hypothetical protein; Provisional; Region: PRK05208 218493014971 3 probable transmembrane helices predicted for SBG2751 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 218493014973 1 probable transmembrane helix predicted for SBG2752 by TMHMM2.0 at aa 4-26 218493014974 oxidoreductase; Provisional; Region: PRK07985 218493014975 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 218493014976 NAD binding site [chemical binding]; other site 218493014977 metal binding site [ion binding]; metal-binding site 218493014978 active site 218493014981 biopolymer transport protein ExbD; Provisional; Region: PRK11267 218493014982 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218493014984 1 probable transmembrane helix predicted for SBG2756 by TMHMM2.0 at aa 20-42 218493014985 biopolymer transport protein ExbB; Provisional; Region: PRK10414 218493014987 3 probable transmembrane helices predicted for SBG2757 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 218493014988 cystathionine beta-lyase; Provisional; Region: PRK08114 218493014989 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218493014990 homodimer interface [polypeptide binding]; other site 218493014991 substrate-cofactor binding pocket; other site 218493014992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493014993 catalytic residue [active] 218493014996 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218493014997 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218493014998 4 probable transmembrane helices predicted for SBG2759 by TMHMM2.0 at aa 16-38, 66-88, 158-180 and 190-212 218493015001 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 218493015002 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218493015003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493015004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493015008 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 218493015009 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 218493015010 dimer interface [polypeptide binding]; other site 218493015011 active site 218493015012 metal binding site [ion binding]; metal-binding site 218493015017 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218493015018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218493015019 active site 218493015020 catalytic tetrad [active] 218493015025 signal peptide predicted for SBG2763 by SignalP 2.0 HMM (Signal peptide probabilty 0.660) with cleavage site probability 0.558 between residues 34 and 35 218493015026 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493015027 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218493015028 transmembrane helices; other site 218493015029 12 probable transmembrane helices predicted for SBG2763 by TMHMM2.0 at aa 7-25, 35-52, 57-76, 91-110,131-148, 227-249, 275-294, 299-321, 334-356, 371-393,400-422 and 459-481 218493015031 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 218493015032 nucleotide binding site/active site [active] 218493015034 hypothetical protein; Provisional; Region: PRK01254 218493015035 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 218493015036 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 218493015040 FtsI repressor; Provisional; Region: PRK10883 218493015041 signal peptide predicted for SBG2766 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 27 and 28 218493015042 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 218493015043 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 218493015046 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 218493015047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218493015048 putative acyl-acceptor binding pocket; other site 218493015050 1 probable transmembrane helix predicted for SBG2767 by TMHMM2.0 at aa 2-24 218493015051 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 218493015052 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 218493015053 CAP-like domain; other site 218493015054 active site 218493015055 primary dimer interface [polypeptide binding]; other site 218493015056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218493015061 signal peptide predicted for SBG2769 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21 218493015062 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 218493015064 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 218493015065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493015066 active site 218493015067 phosphorylation site [posttranslational modification] 218493015068 intermolecular recognition site; other site 218493015069 dimerization interface [polypeptide binding]; other site 218493015070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493015071 DNA binding site [nucleotide binding] 218493015074 sensor protein QseC; Provisional; Region: PRK10337 218493015075 signal peptide predicted for SBG2771 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.742 between residues 34 and 35 218493015076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493015077 dimer interface [polypeptide binding]; other site 218493015078 phosphorylation site [posttranslational modification] 218493015079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493015080 ATP binding site [chemical binding]; other site 218493015081 Mg2+ binding site [ion binding]; other site 218493015082 G-X-G motif; other site 218493015083 2 probable transmembrane helices predicted for SBG2771 by TMHMM2.0 at aa 13-32 and 159-181 218493015087 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 218493015089 Uncharacterized conserved protein [Function unknown]; Region: COG1359 218493015091 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 218493015092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493015093 ATP binding site [chemical binding]; other site 218493015094 Mg2+ binding site [ion binding]; other site 218493015095 G-X-G motif; other site 218493015096 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218493015097 anchoring element; other site 218493015098 dimer interface [polypeptide binding]; other site 218493015099 ATP binding site [chemical binding]; other site 218493015100 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 218493015101 active site 218493015102 metal binding site [ion binding]; metal-binding site 218493015103 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218493015108 esterase YqiA; Provisional; Region: PRK11071 218493015110 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 218493015111 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218493015112 active site 218493015113 metal binding site [ion binding]; metal-binding site 218493015114 hexamer interface [polypeptide binding]; other site 218493015117 putative dehydrogenase; Provisional; Region: PRK11039 218493015119 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 218493015120 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218493015121 dimer interface [polypeptide binding]; other site 218493015122 ADP-ribose binding site [chemical binding]; other site 218493015123 active site 218493015124 nudix motif; other site 218493015125 metal binding site [ion binding]; metal-binding site 218493015127 signal peptide predicted for SBG2779 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.952 between residues 24 and 25 218493015128 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 218493015131 hypothetical protein; Provisional; Region: PRK11653 218493015132 signal peptide predicted for SBG2780 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.369 between residues 36 and 37 218493015134 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 218493015136 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 218493015137 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 218493015138 putative active site [active] 218493015139 metal binding site [ion binding]; metal-binding site 218493015141 zinc transporter ZupT; Provisional; Region: PRK04201 218493015142 signal peptide predicted for SBG2783 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.726 between residues 25 and 26 218493015143 ZIP Zinc transporter; Region: Zip; pfam02535 218493015144 8 probable transmembrane helices predicted for SBG2783 by TMHMM2.0 at aa 4-26, 33-55, 65-87, 108-130,140-162, 169-191, 195-217 and 234-256 218493015146 this CDS carries a frameshift mutation following codon 76 218493015147 signal peptide predicted for SBG2784 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 27 and 28 218493015148 1 probable transmembrane helix predicted for SBG2784 by TMHMM2.0 at aa 9-31 218493015150 signal peptide predicted for SBG2786 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.543 between residues 29 and 30 218493015151 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 218493015152 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 218493015153 catalytic residues [active] 218493015154 hinge region; other site 218493015155 alpha helical domain; other site 218493015157 putative disulfide oxidoreductase; Provisional; Region: PRK04307 218493015158 4 probable transmembrane helices predicted for SBG2787 by TMHMM2.0 at aa 27-49, 59-78, 83-105 and 197-219 218493015160 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 218493015161 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 218493015163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 218493015165 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 218493015166 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 218493015167 putative ribose interaction site [chemical binding]; other site 218493015168 putative ADP binding site [chemical binding]; other site 218493015169 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 218493015170 active site 218493015171 nucleotide binding site [chemical binding]; other site 218493015172 HIGH motif; other site 218493015173 KMSKS motif; other site 218493015177 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 218493015178 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218493015179 metal binding triad; other site 218493015180 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218493015181 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218493015182 metal binding triad; other site 218493015183 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218493015187 Uncharacterized conserved protein [Function unknown]; Region: COG3025 218493015188 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 218493015189 putative active site [active] 218493015190 putative metal binding residues [ion binding]; other site 218493015191 signature motif; other site 218493015192 putative triphosphate binding site [ion binding]; other site 218493015193 CHAD domain; Region: CHAD; cl10506 218493015196 SH3 domain-containing protein; Provisional; Region: PRK10884 218493015197 signal peptide predicted for SBG2793 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 22 and 23 218493015198 Bacterial SH3 domain homologues; Region: SH3b; smart00287 218493015200 1 probable transmembrane helix predicted for SBG2793 by TMHMM2.0 at aa 167-189 218493015201 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 218493015202 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218493015203 active site 218493015204 NTP binding site [chemical binding]; other site 218493015205 metal binding triad [ion binding]; metal-binding site 218493015206 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218493015207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218493015208 Zn2+ binding site [ion binding]; other site 218493015209 Mg2+ binding site [ion binding]; other site 218493015212 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 218493015213 7 probable transmembrane helices predicted for SBG2795 by TMHMM2.0 at aa 13-35, 50-69, 90-109, 119-136,187-209, 224-246 and 253-272 218493015215 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 218493015216 homooctamer interface [polypeptide binding]; other site 218493015217 active site 218493015219 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 218493015220 5 probable transmembrane helices predicted for SBG2797 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158 218493015224 transcriptional activator TtdR; Provisional; Region: PRK09801 218493015225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493015226 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 218493015227 putative effector binding pocket; other site 218493015228 putative dimerization interface [polypeptide binding]; other site 218493015232 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 218493015235 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 218493015237 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493015238 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218493015239 transmembrane helices; other site 218493015241 12 probable transmembrane helices predicted for SBG2801 by TMHMM2.0 at aa 7-29, 33-50, 52-74, 94-116,191-213, 235-257, 290-307, 311-328, 341-363, 373-395,408-430 and 463-485 218493015242 UGMP family protein; Validated; Region: PRK09604 218493015245 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 218493015248 DNA primase; Validated; Region: dnaG; PRK05667 218493015249 CHC2 zinc finger; Region: zf-CHC2; pfam01807 218493015250 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218493015251 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218493015252 active site 218493015253 metal binding site [ion binding]; metal-binding site 218493015254 interdomain interaction site; other site 218493015255 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 218493015256 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 218493015262 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 218493015263 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 218493015264 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218493015265 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 218493015266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218493015267 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218493015268 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218493015269 DNA binding residues [nucleotide binding] 218493015278 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 218493015279 active site 218493015280 SUMO-1 interface [polypeptide binding]; other site 218493015282 this phage is almost identical to bacteriophage 186, carrying the tum genes 218493015283 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 218493015284 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218493015286 tail protein; Provisional; Region: D; PHA02561 218493015287 signal peptide predicted for SBG2807 by SignalP 2.0 HMM (Signal peptide probabilty 0.767) with cleavage site probability 0.758 between residues 23 and 24 218493015289 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 218493015291 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 218493015292 4 probable transmembrane helices predicted for SBG2809 by TMHMM2.0 at aa 537-559, 566-588, 593-612 and 619-638 218493015293 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 218493015295 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 218493015297 major tail tube protein; Provisional; Region: FII; PHA02600 218493015299 major tail sheath protein; Provisional; Region: FI; PHA02560 218493015301 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 218493015303 signal peptide predicted for SBG2814 by SignalP 2.0 HMM (Signal peptide probabilty 0.907) with cleavage site probability 0.646 between residues 19 and 20 218493015304 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 218493015305 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 218493015306 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 218493015307 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 218493015312 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 218493015314 baseplate assembly protein; Provisional; Region: J; PHA02568 218493015316 baseplate wedge subunit; Provisional; Region: W; PHA02516 218493015318 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 218493015319 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 218493015321 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 218493015323 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 218493015325 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 218493015327 1 probable transmembrane helix predicted for SBG2822 by TMHMM2.0 at aa 31-53 218493015328 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 218493015329 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493015330 catalytic residue [active] 218493015332 Phage holin family 2; Region: Phage_holin_2; pfam04550 218493015333 signal peptide predicted for SBG2824 by SignalP 2.0 HMM (Signal peptide probabilty 0.779) with cleavage site probability 0.771 between residues 25 and 26 218493015335 3 probable transmembrane helices predicted for SBG2824 by TMHMM2.0 at aa 10-27, 34-56 and 60-82 218493015336 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 218493015338 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 218493015340 terminase endonuclease subunit; Provisional; Region: M; PHA02537 218493015341 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 218493015344 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 218493015346 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 218493015348 terminase ATPase subunit; Provisional; Region: P; PHA02535 218493015349 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 218493015352 portal vertex protein; Provisional; Region: Q; PHA02536 218493015353 Phage portal protein; Region: Phage_portal; pfam04860 218493015355 Low G+C region 218493015356 cos site 218493015357 2 probable transmembrane helices predicted for SBG2834 by TMHMM2.0 at aa 4-21 and 34-53 218493015358 DinI-like family; Region: DinI; pfam06183 218493015360 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 218493015362 DksA-like zinc finger domain containing protein; Region: PHA00080 218493015365 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 218493015366 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 218493015367 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 218493015369 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 218493015371 integrase; Provisional; Region: int; PHA02601 218493015372 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 218493015373 dimer interface [polypeptide binding]; other site 218493015374 active site 218493015375 catalytic residues [active] 218493015376 Int/Topo IB signature motif; other site 218493015378 signal peptide predicted for SBG2846 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.771 between residues 21 and 22 218493015379 YecR-like lipoprotein; Region: YecR; cl10256 218493015382 signal peptide predicted for SBG2848 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 23 and 24 218493015383 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 218493015385 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 218493015386 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 218493015387 FAD binding pocket [chemical binding]; other site 218493015388 FAD binding motif [chemical binding]; other site 218493015389 phosphate binding motif [ion binding]; other site 218493015390 NAD binding pocket [chemical binding]; other site 218493015393 Predicted transcriptional regulators [Transcription]; Region: COG1695 218493015394 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 218493015396 signal peptide predicted for SBG2851 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.494 between residues 33 and 34 218493015397 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218493015398 Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998 218493015399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493015400 dimerization interface [polypeptide binding]; other site 218493015401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218493015402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493015403 dimer interface [polypeptide binding]; other site 218493015404 putative CheW interface [polypeptide binding]; other site 218493015407 1 probable transmembrane helix predicted for SBG2851 by TMHMM2.0 at aa 12-34 218493015408 PAS fold; Region: PAS_3; pfam08447 218493015409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493015410 putative active site [active] 218493015411 heme pocket [chemical binding]; other site 218493015412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218493015413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493015414 dimer interface [polypeptide binding]; other site 218493015415 putative CheW interface [polypeptide binding]; other site 218493015418 1 probable transmembrane helix predicted for SBG2852 by TMHMM2.0 at aa 168-190 218493015420 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 218493015421 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493015422 inhibitor-cofactor binding pocket; inhibition site 218493015423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493015424 catalytic residue [active] 218493015427 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218493015428 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 218493015429 active site 218493015430 FMN binding site [chemical binding]; other site 218493015431 2,4-decadienoyl-CoA binding site; other site 218493015432 catalytic residue [active] 218493015433 4Fe-4S cluster binding site [ion binding]; other site 218493015434 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 218493015435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493015438 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 218493015439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493015440 S-adenosylmethionine binding site [chemical binding]; other site 218493015443 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 218493015445 signal peptide predicted for SBG2857 by SignalP 2.0 HMM (Signal peptide probabilty 0.953) with cleavage site probability 0.401 between residues 36 and 37 218493015446 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218493015447 putative active site [active] 218493015448 1 probable transmembrane helix predicted for SBG2857 by TMHMM2.0 at aa 13-35 218493015450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218493015451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218493015453 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 218493015454 9 probable transmembrane helices predicted for SBG2859 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136,142-161, 198-220, 235-257, 264-286 and 290-312 218493015456 serine/threonine transporter SstT; Provisional; Region: PRK13628 218493015457 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218493015458 8 probable transmembrane helices predicted for SBG2860 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 141-163,191-213, 218-240, 292-314 and 329-351 218493015462 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 218493015463 galactarate dehydratase; Region: galactar-dH20; TIGR03248 218493015464 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 218493015469 Glucuronate isomerase; Region: UxaC; pfam02614 218493015470 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 218493015472 signal peptide predicted for SBG2863 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.419 between residues 30 and 31 218493015473 D-galactonate transporter; Region: 2A0114; TIGR00893 218493015474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493015475 putative substrate translocation pore; other site 218493015476 11 probable transmembrane helices predicted for SBG2863 by TMHMM2.0 at aa 7-24, 47-69, 76-98, 102-124,137-159, 163-185, 267-289, 304-322, 327-349, 359-381 and 388-410 218493015478 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 218493015479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493015480 DNA-binding site [nucleotide binding]; DNA binding site 218493015481 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493015485 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218493015486 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218493015487 6 probable transmembrane helices predicted for SBG2865 by TMHMM2.0 at aa 20-38, 40-62, 66-88, 123-145,155-177 and 190-212 218493015490 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 218493015491 signal peptide predicted for SBG2866 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.414 between residues 34 and 35 218493015492 1 probable transmembrane helix predicted for SBG2866 by TMHMM2.0 at aa 12-31 218493015493 signal peptide predicted for SBG2867 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 20 and 21 218493015494 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 218493015496 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 218493015498 1 probable transmembrane helix predicted for SBG2868 by TMHMM2.0 at aa 81-98 218493015499 YqjK-like protein; Region: YqjK; pfam13997 218493015500 Predicted membrane protein [Function unknown]; Region: COG2259 218493015501 4 probable transmembrane helices predicted for SBG2870 by TMHMM2.0 at aa 7-25, 45-67, 72-94 and 104-126 218493015503 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 218493015504 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 218493015505 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 218493015506 putative dimer interface [polypeptide binding]; other site 218493015507 N-terminal domain interface [polypeptide binding]; other site 218493015508 putative substrate binding pocket (H-site) [chemical binding]; other site 218493015510 Predicted membrane protein [Function unknown]; Region: COG3152 218493015512 3 probable transmembrane helices predicted for SBG2872 by TMHMM2.0 at aa 24-46, 51-70 and 82-101 218493015513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493015514 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 218493015515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493015516 dimerization interface [polypeptide binding]; other site 218493015520 Pirin-related protein [General function prediction only]; Region: COG1741 218493015521 Pirin; Region: Pirin; pfam02678 218493015523 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 218493015525 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493015526 serine transporter; Region: stp; TIGR00814 218493015527 11 probable transmembrane helices predicted for SBG2876 by TMHMM2.0 at aa 38-60, 65-87, 112-134,154-171, 184-206, 221-243, 264-286, 318-340, 363-385,389-411 and 423-442 218493015529 L-serine dehydratase TdcG; Provisional; Region: PRK15040 218493015530 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218493015531 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218493015534 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 218493015535 Pyruvate formate lyase 1; Region: PFL1; cd01678 218493015536 coenzyme A binding site [chemical binding]; other site 218493015537 active site 218493015538 catalytic residues [active] 218493015539 glycine loop; other site 218493015543 propionate/acetate kinase; Provisional; Region: PRK12379 218493015544 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 218493015548 threonine/serine transporter TdcC; Provisional; Region: PRK13629 218493015549 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493015550 11 probable transmembrane helices predicted for SBG2880 by TMHMM2.0 at aa 23-40, 44-66, 97-119,134-156, 163-185, 212-234, 255-277, 311-333, 358-380,390-409 and 422-440 218493015552 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 218493015553 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218493015554 tetramer interface [polypeptide binding]; other site 218493015555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493015556 catalytic residue [active] 218493015560 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 218493015561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493015562 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 218493015563 putative substrate binding pocket [chemical binding]; other site 218493015564 putative dimerization interface [polypeptide binding]; other site 218493015567 glycerate kinase I; Provisional; Region: PRK10342 218493015569 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 218493015570 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218493015573 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 218493015575 galactarate dehydratase; Region: galactar-dH20; TIGR03248 218493015576 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 218493015577 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 218493015580 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 218493015581 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 218493015582 intersubunit interface [polypeptide binding]; other site 218493015583 active site 218493015584 zinc binding site [ion binding]; other site 218493015585 Na+ binding site [ion binding]; other site 218493015588 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 218493015590 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493015591 active site 218493015592 phosphorylation site [posttranslational modification] 218493015594 signal peptide predicted for SBG2890 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493015595 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 218493015596 active site 218493015597 P-loop; other site 218493015598 phosphorylation site [posttranslational modification] 218493015600 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 218493015601 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 218493015602 9 probable transmembrane helices predicted for SBG2891 by TMHMM2.0 at aa 4-26, 39-61, 91-113, 134-156,225-247, 299-321, 331-348, 353-375 and 411-433 218493015605 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 218493015606 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 218493015607 putative NAD(P) binding site [chemical binding]; other site 218493015608 catalytic Zn binding site [ion binding]; other site 218493015613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493015614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493015615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493015620 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 218493015621 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 218493015622 putative SAM binding site [chemical binding]; other site 218493015623 putative homodimer interface [polypeptide binding]; other site 218493015626 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 218493015627 signal peptide predicted for SBG2895 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.637 between residues 31 and 32 218493015628 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 218493015629 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 218493015630 putative ligand binding site [chemical binding]; other site 218493015634 TIGR00252 family protein; Region: TIGR00252 218493015636 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 218493015637 dimer interface [polypeptide binding]; other site 218493015638 active site 218493015639 outer membrane lipoprotein; Provisional; Region: PRK11023 218493015640 signal peptide predicted for SBG2898 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.420 between residues 23 and 24 218493015641 BON domain; Region: BON; pfam04972 218493015642 BON domain; Region: BON; pfam04972 218493015643 1 probable transmembrane helix predicted for SBG2898 by TMHMM2.0 at aa 7-29 218493015647 Predicted permease; Region: DUF318; pfam03773 218493015649 9 probable transmembrane helices predicted for SBG2899 by TMHMM2.0 at aa 15-32, 74-96, 111-133, 146-168,173-195, 226-248, 263-285, 298-320 and 325-344 218493015651 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 218493015652 NADH(P)-binding; Region: NAD_binding_10; pfam13460 218493015653 NAD binding site [chemical binding]; other site 218493015654 active site 218493015656 intracellular protease, PfpI family; Region: PfpI; TIGR01382 218493015657 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 218493015658 proposed catalytic triad [active] 218493015659 conserved cys residue [active] 218493015661 hypothetical protein; Provisional; Region: PRK03467 218493015662 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 218493015663 GIY-YIG motif/motif A; other site 218493015664 putative active site [active] 218493015665 putative metal binding site [ion binding]; other site 218493015666 1 probable transmembrane helix predicted for SBG2903 by TMHMM2.0 at aa 10-32 218493015668 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218493015669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493015670 Coenzyme A binding pocket [chemical binding]; other site 218493015672 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 218493015674 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218493015675 Peptidase family U32; Region: Peptidase_U32; pfam01136 218493015678 putative protease; Provisional; Region: PRK15447 218493015679 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218493015681 hypothetical protein; Provisional; Region: PRK10508 218493015682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 218493015684 tryptophan permease; Provisional; Region: PRK10483 218493015685 aromatic amino acid transport protein; Region: araaP; TIGR00837 218493015686 10 probable transmembrane helices predicted for SBG2909 by TMHMM2.0 at aa 10-32, 59-81, 96-118,125-147, 162-184, 197-219, 256-278, 290-312, 317-339 and 360-382 218493015688 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218493015689 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218493015690 ATP binding site [chemical binding]; other site 218493015691 Mg++ binding site [ion binding]; other site 218493015692 motif III; other site 218493015693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493015694 nucleotide binding region [chemical binding]; other site 218493015695 ATP-binding site [chemical binding]; other site 218493015696 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 218493015697 putative RNA binding site [nucleotide binding]; other site 218493015703 lipoprotein NlpI; Provisional; Region: PRK11189 218493015704 signal peptide predicted for SBG2911 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.597 between residues 25 and 26 218493015705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493015706 binding surface 218493015707 TPR motif; other site 218493015712 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 218493015713 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 218493015714 RNase E interface [polypeptide binding]; other site 218493015715 trimer interface [polypeptide binding]; other site 218493015716 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 218493015717 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 218493015718 RNase E interface [polypeptide binding]; other site 218493015719 trimer interface [polypeptide binding]; other site 218493015720 active site 218493015721 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 218493015722 putative nucleic acid binding region [nucleotide binding]; other site 218493015723 G-X-X-G motif; other site 218493015724 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 218493015725 RNA binding site [nucleotide binding]; other site 218493015726 domain interface; other site 218493015734 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 218493015735 16S/18S rRNA binding site [nucleotide binding]; other site 218493015736 S13e-L30e interaction site [polypeptide binding]; other site 218493015737 25S rRNA binding site [nucleotide binding]; other site 218493015740 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 218493015741 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 218493015742 RNA binding site [nucleotide binding]; other site 218493015743 active site 218493015744 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 218493015747 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 218493015750 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218493015751 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 218493015752 translation initiation factor IF-2; Region: IF-2; TIGR00487 218493015753 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218493015754 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 218493015755 G1 box; other site 218493015756 putative GEF interaction site [polypeptide binding]; other site 218493015757 GTP/Mg2+ binding site [chemical binding]; other site 218493015758 Switch I region; other site 218493015759 G2 box; other site 218493015760 G3 box; other site 218493015761 Switch II region; other site 218493015762 G4 box; other site 218493015763 G5 box; other site 218493015764 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 218493015765 Translation-initiation factor 2; Region: IF-2; pfam11987 218493015766 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 218493015775 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 218493015776 NusA N-terminal domain; Region: NusA_N; pfam08529 218493015777 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 218493015778 RNA binding site [nucleotide binding]; other site 218493015779 homodimer interface [polypeptide binding]; other site 218493015780 NusA-like KH domain; Region: KH_5; pfam13184 218493015781 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218493015782 G-X-X-G motif; other site 218493015783 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 218493015784 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 218493015787 ribosome maturation protein RimP; Reviewed; Region: PRK00092 218493015788 hypothetical protein; Provisional; Region: PRK14641 218493015789 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 218493015790 putative oligomer interface [polypeptide binding]; other site 218493015791 putative RNA binding site [nucleotide binding]; other site 218493015793 argininosuccinate synthase; Validated; Region: PRK05370 218493015797 signal peptide predicted for SBG2921 by SignalP 2.0 HMM (Signal peptide probabilty 0.691) with cleavage site probability 0.192 between residues 60 and 61 218493015798 Preprotein translocase SecG subunit; Region: SecG; pfam03840 218493015800 2 probable transmembrane helices predicted for SBG2921 by TMHMM2.0 at aa 5-22 and 51-73 218493015801 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 218493015802 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 218493015803 active site 218493015804 substrate binding site [chemical binding]; other site 218493015805 metal binding site [ion binding]; metal-binding site 218493015811 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 218493015812 dihydropteroate synthase; Region: DHPS; TIGR01496 218493015813 substrate binding pocket [chemical binding]; other site 218493015814 dimer interface [polypeptide binding]; other site 218493015815 inhibitor binding site; inhibition site 218493015819 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 218493015820 signal peptide predicted for SBG2924 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.622 between residues 23 and 24 218493015821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493015822 Walker A motif; other site 218493015823 ATP binding site [chemical binding]; other site 218493015824 Walker B motif; other site 218493015825 arginine finger; other site 218493015826 Peptidase family M41; Region: Peptidase_M41; pfam01434 218493015833 2 probable transmembrane helices predicted for SBG2924 by TMHMM2.0 at aa 5-24 and 97-119 218493015834 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 218493015835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493015836 S-adenosylmethionine binding site [chemical binding]; other site 218493015838 RNA-binding protein YhbY; Provisional; Region: PRK10343 218493015841 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 218493015842 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 218493015843 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218493015848 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 218493015849 signal peptide predicted for SBG2928 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 20 and 21 218493015850 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 218493015852 GTPase CgtA; Reviewed; Region: obgE; PRK12298 218493015853 GTP1/OBG; Region: GTP1_OBG; pfam01018 218493015854 Obg GTPase; Region: Obg; cd01898 218493015855 G1 box; other site 218493015856 GTP/Mg2+ binding site [chemical binding]; other site 218493015857 Switch I region; other site 218493015858 G2 box; other site 218493015859 G3 box; other site 218493015860 Switch II region; other site 218493015861 G4 box; other site 218493015862 G5 box; other site 218493015867 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218493015868 signal peptide predicted for SBG2930 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.840 between residues 20 and 21 218493015869 EamA-like transporter family; Region: EamA; pfam00892 218493015870 EamA-like transporter family; Region: EamA; pfam00892 218493015871 10 probable transmembrane helices predicted for SBG2930 by TMHMM2.0 at aa 7-26, 36-58, 71-93, 103-120,129-151, 155-177, 190-212, 217-239, 246-268 and 278-300 218493015874 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 218493015877 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218493015878 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218493015879 substrate binding pocket [chemical binding]; other site 218493015880 chain length determination region; other site 218493015881 substrate-Mg2+ binding site; other site 218493015882 catalytic residues [active] 218493015883 aspartate-rich region 1; other site 218493015884 active site lid residues [active] 218493015885 aspartate-rich region 2; other site 218493015890 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 218493015891 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 218493015892 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218493015893 hinge; other site 218493015894 active site 218493015896 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 218493015898 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 218493015899 anti sigma factor interaction site; other site 218493015900 regulatory phosphorylation site [posttranslational modification]; other site 218493015902 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 218493015903 signal peptide predicted for SBG2937 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.863 between residues 21 and 22 218493015905 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 218493015906 signal peptide predicted for SBG2938 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.462 between residues 28 and 29 218493015907 mce related protein; Region: MCE; pfam02470 218493015909 1 probable transmembrane helix predicted for SBG2938 by TMHMM2.0 at aa 9-31 218493015910 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 218493015911 conserved hypothetical integral membrane protein; Region: TIGR00056 218493015913 5 probable transmembrane helices predicted for SBG2939 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258 218493015914 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 218493015915 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 218493015916 Walker A/P-loop; other site 218493015917 ATP binding site [chemical binding]; other site 218493015918 Q-loop/lid; other site 218493015919 ABC transporter signature motif; other site 218493015920 Walker B; other site 218493015921 D-loop; other site 218493015922 H-loop/switch region; other site 218493015926 signal peptide predicted for SBG2941 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.714 between residues 18 and 19 218493015927 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 218493015928 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218493015929 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218493015930 9 probable transmembrane helices predicted for SBG2941 by TMHMM2.0 at aa 2-24, 39-61, 68-90, 129-151,172-194, 204-226, 239-261, 271-290 and 297-319 218493015933 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 218493015934 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 218493015935 putative active site [active] 218493015936 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 218493015940 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 218493015941 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 218493015943 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 218493015944 signal peptide predicted for SBG2944 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.636 between residues 25 and 26 218493015945 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 218493015946 1 probable transmembrane helix predicted for SBG2944 by TMHMM2.0 at aa 7-25 218493015948 signal peptide predicted for SBG2945 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.957 between residues 34 and 35 218493015949 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 218493015950 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 218493015952 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 218493015953 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 218493015954 Walker A/P-loop; other site 218493015955 ATP binding site [chemical binding]; other site 218493015956 Q-loop/lid; other site 218493015957 ABC transporter signature motif; other site 218493015958 Walker B; other site 218493015959 D-loop; other site 218493015960 H-loop/switch region; other site 218493015964 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 218493015965 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 218493015966 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 218493015967 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 218493015973 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 218493015974 30S subunit binding site; other site 218493015976 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493015977 active site 218493015978 phosphorylation site [posttranslational modification] 218493015981 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 218493015984 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218493015985 dimerization domain swap beta strand [polypeptide binding]; other site 218493015986 regulatory protein interface [polypeptide binding]; other site 218493015987 active site 218493015988 regulatory phosphorylation site [posttranslational modification]; other site 218493015992 signal peptide predicted for SBG2952 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.971 between residues 21 and 22 218493015994 signal peptide predicted for SBG2953 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.971 between residues 21 and 22 218493015996 signal peptide predicted for SBG2954 by SignalP 2.0 HMM (Signal peptide probabilty 0.959) with cleavage site probability 0.955 between residues 21 and 22 218493015998 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 218493015999 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 218493016000 signal peptide predicted for SBG2956 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.426 between residues 45 and 46 218493016001 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 218493016002 Transglycosylase; Region: Transgly; cl17702 218493016004 1 probable transmembrane helix predicted for SBG2956 by TMHMM2.0 at aa 19-41 218493016005 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 218493016006 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 218493016007 conserved cys residue [active] 218493016009 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 218493016010 signal peptide predicted for SBG2958 by SignalP 2.0 HMM (Signal peptide probabilty 0.957) with cleavage site probability 0.478 between residues 41 and 42 218493016011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493016012 putative active site [active] 218493016013 heme pocket [chemical binding]; other site 218493016014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493016015 dimer interface [polypeptide binding]; other site 218493016016 phosphorylation site [posttranslational modification] 218493016017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493016018 ATP binding site [chemical binding]; other site 218493016019 Mg2+ binding site [ion binding]; other site 218493016020 G-X-G motif; other site 218493016021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493016022 active site 218493016023 phosphorylation site [posttranslational modification] 218493016024 intermolecular recognition site; other site 218493016025 dimerization interface [polypeptide binding]; other site 218493016026 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218493016027 putative binding surface; other site 218493016028 active site 218493016034 2 probable transmembrane helices predicted for SBG2958 by TMHMM2.0 at aa 20-42 and 55-77 218493016035 radical SAM protein, TIGR01212 family; Region: TIGR01212 218493016036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493016037 FeS/SAM binding site; other site 218493016039 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 218493016040 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 218493016041 active site 218493016042 dimer interface [polypeptide binding]; other site 218493016043 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 218493016044 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 218493016045 active site 218493016046 FMN binding site [chemical binding]; other site 218493016047 substrate binding site [chemical binding]; other site 218493016048 3Fe-4S cluster binding site [ion binding]; other site 218493016049 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 218493016050 domain interface; other site 218493016057 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 218493016058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493016059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493016063 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 218493016064 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 218493016065 Na binding site [ion binding]; other site 218493016066 putative substrate binding site [chemical binding]; other site 218493016068 12 probable transmembrane helices predicted for SBG2962 by TMHMM2.0 at aa 21-43, 53-75, 96-118,128-150, 152-174, 189-211, 223-245, 255-277, 296-318,323-345, 358-375 and 379-398 218493016069 cytosine deaminase; Provisional; Region: PRK09230 218493016070 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 218493016071 active site 218493016073 Domain of unknown function (DUF386); Region: DUF386; cl01047 218493016075 N-acetylmannosamine kinase; Provisional; Region: PRK05082 218493016076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493016077 nucleotide binding site [chemical binding]; other site 218493016080 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 218493016081 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 218493016082 putative active site cavity [active] 218493016085 putative sialic acid transporter; Provisional; Region: PRK03893 218493016086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493016087 putative substrate translocation pore; other site 218493016088 13 probable transmembrane helices predicted for SBG2967 by TMHMM2.0 at aa 20-42, 57-79, 86-108,112-134, 147-166, 171-190, 222-244, 248-267, 274-296,311-333, 353-375, 404-426 and 433-452 218493016092 N-acetylneuraminate lyase; Provisional; Region: PRK04147 218493016093 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 218493016094 inhibitor site; inhibition site 218493016095 active site 218493016096 dimer interface [polypeptide binding]; other site 218493016097 catalytic residue [active] 218493016101 transcriptional regulator NanR; Provisional; Region: PRK03837 218493016102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493016103 DNA-binding site [nucleotide binding]; DNA binding site 218493016104 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493016108 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 218493016110 stringent starvation protein A; Provisional; Region: sspA; PRK09481 218493016111 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 218493016112 C-terminal domain interface [polypeptide binding]; other site 218493016113 putative GSH binding site (G-site) [chemical binding]; other site 218493016114 dimer interface [polypeptide binding]; other site 218493016115 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 218493016116 dimer interface [polypeptide binding]; other site 218493016117 N-terminal domain interface [polypeptide binding]; other site 218493016120 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 218493016123 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 218493016124 23S rRNA interface [nucleotide binding]; other site 218493016125 L3 interface [polypeptide binding]; other site 218493016128 Predicted ATPase [General function prediction only]; Region: COG1485 218493016131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 218493016132 hypothetical protein; Provisional; Region: PRK11677 218493016133 1 probable transmembrane helix predicted for SBG2975 by TMHMM2.0 at aa 4-26 218493016135 serine endoprotease; Provisional; Region: PRK10139 218493016136 signal peptide predicted for SBG2976 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 27 and 28 218493016137 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218493016138 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218493016139 protein binding site [polypeptide binding]; other site 218493016140 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218493016141 1 probable transmembrane helix predicted for SBG2976 by TMHMM2.0 at aa 7-29 218493016145 serine endoprotease; Provisional; Region: PRK10898 218493016146 signal peptide predicted for SBG2977 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.711 between residues 27 and 28 218493016147 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218493016148 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218493016149 1 probable transmembrane helix predicted for SBG2977 by TMHMM2.0 at aa 5-27 218493016152 malate dehydrogenase; Provisional; Region: PRK05086 218493016153 signal peptide predicted for SBG2978 by SignalP 2.0 HMM (Signal peptide probabilty 0.797) with cleavage site probability 0.754 between residues 17 and 18 218493016154 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 218493016155 NAD binding site [chemical binding]; other site 218493016156 dimerization interface [polypeptide binding]; other site 218493016157 Substrate binding site [chemical binding]; other site 218493016161 arginine repressor; Provisional; Region: PRK05066 218493016162 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218493016163 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218493016166 signal peptide predicted for SBG2980 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493016167 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493016169 signal peptide predicted for SBG2981 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 22 and 23 218493016170 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493016172 1 probable transmembrane helix predicted for SBG2981 by TMHMM2.0 at aa 5-24 218493016173 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 218493016174 RNAase interaction site [polypeptide binding]; other site 218493016175 signal peptide predicted for SBG2983 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.968 between residues 53 and 54 218493016176 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 218493016177 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218493016178 10 probable transmembrane helices predicted for SBG2983 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112,119-136, 151-168, 370-392, 407-426, 433-452 and 481-503 218493016181 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 218493016182 signal peptide predicted for SBG2984 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.629 between residues 30 and 31 218493016183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493016184 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493016186 1 probable transmembrane helix predicted for SBG2984 by TMHMM2.0 at aa 12-31 218493016187 transcriptional regulator; Provisional; Region: PRK10632 218493016188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493016189 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218493016190 putative effector binding pocket; other site 218493016191 dimerization interface [polypeptide binding]; other site 218493016195 protease TldD; Provisional; Region: tldD; PRK10735 218493016197 signal peptide predicted for SBG2987 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.565 between residues 29 and 30 218493016198 hypothetical protein; Provisional; Region: PRK10899 218493016199 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218493016200 1 probable transmembrane helix predicted for SBG2987 by TMHMM2.0 at aa 7-29 218493016201 ribonuclease G; Provisional; Region: PRK11712 218493016202 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218493016203 homodimer interface [polypeptide binding]; other site 218493016204 oligonucleotide binding site [chemical binding]; other site 218493016206 Maf-like protein; Region: Maf; pfam02545 218493016207 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218493016208 active site 218493016209 dimer interface [polypeptide binding]; other site 218493016212 rod shape-determining protein MreD; Provisional; Region: PRK11060 218493016214 5 probable transmembrane helices predicted for SBG2990 by TMHMM2.0 at aa 10-24, 31-53, 68-90, 97-119 and 134-151 218493016215 rod shape-determining protein MreC; Region: mreC; TIGR00219 218493016216 rod shape-determining protein MreC; Region: MreC; pfam04085 218493016218 1 probable transmembrane helix predicted for SBG2991 by TMHMM2.0 at aa 13-35 218493016219 rod shape-determining protein MreB; Provisional; Region: PRK13927 218493016220 MreB and similar proteins; Region: MreB_like; cd10225 218493016221 nucleotide binding site [chemical binding]; other site 218493016222 Mg binding site [ion binding]; other site 218493016223 putative protofilament interaction site [polypeptide binding]; other site 218493016224 RodZ interaction site [polypeptide binding]; other site 218493016226 regulatory protein CsrD; Provisional; Region: PRK11059 218493016227 signal peptide predicted for SBG2993 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.623 between residues 32 and 33 218493016228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493016229 metal binding site [ion binding]; metal-binding site 218493016230 active site 218493016231 I-site; other site 218493016232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493016235 2 probable transmembrane helices predicted for SBG2993 by TMHMM2.0 at aa 10-32 and 130-152 218493016237 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 218493016238 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 218493016239 NADP binding site [chemical binding]; other site 218493016240 dimer interface [polypeptide binding]; other site 218493016245 TMAO/DMSO reductase; Reviewed; Region: PRK05363 218493016246 signal peptide predicted for SBG2995 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.836 between residues 44 and 45 218493016247 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 218493016248 Moco binding site; other site 218493016249 metal coordination site [ion binding]; other site 218493016251 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 218493016252 signal peptide predicted for SBG2996 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.295 between residues 37 and 38 218493016253 6 probable transmembrane helices predicted for SBG2996 by TMHMM2.0 at aa 13-30, 45-67, 79-98, 113-135,148-167 and 171-189 218493016255 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 218493016256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218493016257 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 218493016258 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 218493016264 hypothetical protein; Provisional; Region: PRK10633 218493016266 2 probable transmembrane helices predicted for SBG2998 by TMHMM2.0 at aa 13-32 and 42-64 218493016267 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218493016268 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 218493016269 Na binding site [ion binding]; other site 218493016270 13 probable transmembrane helices predicted for SBG2999 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 122-141,156-178, 191-213, 233-255, 268-290, 319-341, 369-386,391-413, 420-442 and 447-466 218493016274 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 218493016275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 218493016278 signal peptide predicted for SBG3001 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218493016279 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 218493016280 active site 218493016281 zinc binding site [ion binding]; other site 218493016283 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 218493016284 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218493016285 FMN binding site [chemical binding]; other site 218493016286 active site 218493016287 catalytic residues [active] 218493016288 substrate binding site [chemical binding]; other site 218493016291 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 218493016292 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 218493016294 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 218493016295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493016296 DNA methylase; Region: N6_N4_Mtase; pfam01555 218493016299 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 218493016300 1 probable transmembrane helix predicted for SBG3005 by TMHMM2.0 at aa 15-37 218493016301 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 218493016302 signal peptide predicted for SBG3006 by SignalP 2.0 HMM (Signal peptide probabilty 0.619) with cleavage site probability 0.140 between residues 33 and 34 218493016303 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 218493016304 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 218493016305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493016306 metal binding site [ion binding]; metal-binding site 218493016307 active site 218493016308 I-site; other site 218493016309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493016310 7 probable transmembrane helices predicted for SBG3006 by TMHMM2.0 at aa 10-27, 40-62, 77-99, 112-134,139-161, 174-193 and 213-235 218493016317 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 218493016318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493016319 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 218493016323 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 218493016324 signal peptide predicted for SBG3008 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.459 between residues 22 and 23 218493016325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493016326 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493016329 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 218493016330 signal peptide predicted for SBG3009 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.740 between residues 26 and 27 218493016332 12 probable transmembrane helices predicted for SBG3009 by TMHMM2.0 at aa 9-31, 337-359, 366-388,392-414, 438-460, 470-492, 541-563, 872-891, 898-920,925-947, 974-996 and 1006-1028 218493016333 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 218493016334 signal peptide predicted for SBG3010 by SignalP 2.0 HMM (Signal peptide probabilty 0.911) with cleavage site probability 0.771 between residues 18 and 19 218493016336 1 probable transmembrane helix predicted for SBG3010 by TMHMM2.0 at aa 50-72 218493016337 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 218493016338 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 218493016339 trimer interface [polypeptide binding]; other site 218493016340 putative metal binding site [ion binding]; other site 218493016345 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 218493016346 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 218493016347 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 218493016348 shikimate binding site; other site 218493016349 NAD(P) binding site [chemical binding]; other site 218493016352 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 218493016355 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218493016356 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 218493016357 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218493016358 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218493016362 hypothetical protein; Validated; Region: PRK03430 218493016364 hypothetical protein; Provisional; Region: PRK10736 218493016365 DNA protecting protein DprA; Region: dprA; TIGR00732 218493016368 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 218493016369 active site 218493016370 catalytic residues [active] 218493016371 metal binding site [ion binding]; metal-binding site 218493016373 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 218493016374 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 218493016375 putative active site [active] 218493016376 substrate binding site [chemical binding]; other site 218493016377 putative cosubstrate binding site; other site 218493016378 catalytic site [active] 218493016379 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 218493016380 substrate binding site [chemical binding]; other site 218493016384 16S rRNA methyltransferase B; Provisional; Region: PRK10901 218493016385 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 218493016386 putative RNA binding site [nucleotide binding]; other site 218493016387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493016388 S-adenosylmethionine binding site [chemical binding]; other site 218493016392 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 218493016393 TrkA-N domain; Region: TrkA_N; pfam02254 218493016394 TrkA-C domain; Region: TrkA_C; pfam02080 218493016395 TrkA-N domain; Region: TrkA_N; pfam02254 218493016396 TrkA-C domain; Region: TrkA_C; pfam02080 218493016401 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 218493016402 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 218493016405 2 probable transmembrane helices predicted for SBG3021 by TMHMM2.0 at aa 20-42 and 77-99 218493016406 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 218493016407 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 218493016408 DNA binding residues [nucleotide binding] 218493016409 dimer interface [polypeptide binding]; other site 218493016410 metal binding site [ion binding]; metal-binding site 218493016414 hypothetical protein; Provisional; Region: PRK10203 218493016415 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 218493016418 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 218493016419 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 218493016420 alphaNTD homodimer interface [polypeptide binding]; other site 218493016421 alphaNTD - beta interaction site [polypeptide binding]; other site 218493016422 alphaNTD - beta' interaction site [polypeptide binding]; other site 218493016423 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 218493016427 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 218493016428 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 218493016429 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493016430 RNA binding surface [nucleotide binding]; other site 218493016434 30S ribosomal protein S11; Validated; Region: PRK05309 218493016437 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 218493016438 30S ribosomal protein S13; Region: bact_S13; TIGR03631 218493016442 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 218493016443 SecY translocase; Region: SecY; pfam00344 218493016445 10 probable transmembrane helices predicted for SBG3029 by TMHMM2.0 at aa 22-44, 76-98, 119-138,153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414 218493016449 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 218493016453 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 218493016454 23S rRNA binding site [nucleotide binding]; other site 218493016457 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 218493016458 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 218493016459 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 218493016463 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 218493016464 23S rRNA interface [nucleotide binding]; other site 218493016465 5S rRNA interface [nucleotide binding]; other site 218493016466 L27 interface [polypeptide binding]; other site 218493016467 L5 interface [polypeptide binding]; other site 218493016469 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 218493016470 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218493016471 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218493016475 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 218493016479 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 218493016482 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 218493016483 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 218493016484 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 218493016488 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 218493016489 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 218493016490 RNA binding site [nucleotide binding]; other site 218493016493 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 218493016496 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 218493016499 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 218493016500 23S rRNA interface [nucleotide binding]; other site 218493016501 putative translocon interaction site; other site 218493016502 signal recognition particle (SRP54) interaction site; other site 218493016503 L23 interface [polypeptide binding]; other site 218493016504 trigger factor interaction site; other site 218493016507 signal peptide predicted for SBG3042 by SignalP 2.0 HMM (Signal peptide probabilty 0.837) with cleavage site probability 0.334 between residues 35 and 36 218493016508 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 218493016509 23S rRNA interface [nucleotide binding]; other site 218493016510 5S rRNA interface [nucleotide binding]; other site 218493016511 putative antibiotic binding site [chemical binding]; other site 218493016512 L25 interface [polypeptide binding]; other site 218493016513 L27 interface [polypeptide binding]; other site 218493016517 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 218493016518 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 218493016519 G-X-X-G motif; other site 218493016520 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 218493016525 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 218493016526 protein-rRNA interface [nucleotide binding]; other site 218493016527 putative translocon binding site; other site 218493016530 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 218493016533 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 218493016534 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 218493016535 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 218493016539 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 218493016543 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 218493016545 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 218493016548 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 218493016551 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 218493016552 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 218493016553 4 probable transmembrane helices predicted for SBG3051 by TMHMM2.0 at aa 2-21, 55-77, 98-120 and 135-152 218493016557 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 218493016558 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 218493016559 heme binding site [chemical binding]; other site 218493016560 ferroxidase pore; other site 218493016561 ferroxidase diiron center [ion binding]; other site 218493016563 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 218493016565 elongation factor Tu; Reviewed; Region: PRK00049 218493016566 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 218493016567 G1 box; other site 218493016568 GEF interaction site [polypeptide binding]; other site 218493016569 GTP/Mg2+ binding site [chemical binding]; other site 218493016570 Switch I region; other site 218493016571 G2 box; other site 218493016572 G3 box; other site 218493016573 Switch II region; other site 218493016574 G4 box; other site 218493016575 G5 box; other site 218493016576 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218493016577 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218493016578 Antibiotic Binding Site [chemical binding]; other site 218493016584 elongation factor G; Reviewed; Region: PRK00007 218493016585 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 218493016586 G1 box; other site 218493016587 putative GEF interaction site [polypeptide binding]; other site 218493016588 GTP/Mg2+ binding site [chemical binding]; other site 218493016589 Switch I region; other site 218493016590 G2 box; other site 218493016591 G3 box; other site 218493016592 Switch II region; other site 218493016593 G4 box; other site 218493016594 G5 box; other site 218493016595 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 218493016596 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 218493016597 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 218493016604 30S ribosomal protein S7; Validated; Region: PRK05302 218493016607 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 218493016608 S17 interaction site [polypeptide binding]; other site 218493016609 S8 interaction site; other site 218493016610 16S rRNA interaction site [nucleotide binding]; other site 218493016611 streptomycin interaction site [chemical binding]; other site 218493016612 23S rRNA interaction site [nucleotide binding]; other site 218493016613 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 218493016616 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 218493016618 sulfur relay protein TusC; Validated; Region: PRK00211 218493016619 signal peptide predicted for SBG3059 by SignalP 2.0 HMM (Signal peptide probabilty 0.745) with cleavage site probability 0.665 between residues 18 and 19 218493016621 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 218493016623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 218493016624 YheO-like PAS domain; Region: PAS_6; pfam08348 218493016625 HTH domain; Region: HTH_22; pfam13309 218493016627 signal peptide predicted for SBG3062 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.979 between residues 25 and 26 218493016628 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 218493016629 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 218493016630 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218493016634 phi X174 lysis protein; Provisional; Region: PRK02793 218493016636 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 218493016637 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218493016641 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 218493016642 signal peptide predicted for SBG3066 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.396 between residues 19 and 20 218493016643 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 218493016644 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 218493016645 TrkA-N domain; Region: TrkA_N; pfam02254 218493016648 10 probable transmembrane helices predicted for SBG3066 by TMHMM2.0 at aa 5-24, 29-51, 56-75, 87-109,113-135, 148-170, 180-202, 223-245, 265-287 and 294-316 218493016649 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 218493016651 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 218493016652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493016653 Walker A/P-loop; other site 218493016654 ATP binding site [chemical binding]; other site 218493016655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493016656 ABC transporter signature motif; other site 218493016657 Walker B; other site 218493016658 D-loop; other site 218493016659 ABC transporter; Region: ABC_tran_2; pfam12848 218493016660 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493016661 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 218493016668 putative monooxygenase; Provisional; Region: PRK11118 218493016670 putative hydrolase; Provisional; Region: PRK10985 218493016673 hypothetical protein; Provisional; Region: PRK04966 218493016675 signal peptide predicted for SBG3072 by SignalP 2.0 HMM (Signal peptide probabilty 0.766) with cleavage site probability 0.418 between residues 36 and 37 218493016676 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 218493016677 active site 218493016680 hypothetical protein; Provisional; Region: PRK10738 218493016682 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 218493016683 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218493016684 ligand binding site [chemical binding]; other site 218493016685 flexible hinge region; other site 218493016686 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 218493016687 putative switch regulator; other site 218493016688 non-specific DNA interactions [nucleotide binding]; other site 218493016689 DNA binding site [nucleotide binding] 218493016690 sequence specific DNA binding site [nucleotide binding]; other site 218493016691 putative cAMP binding site [chemical binding]; other site 218493016697 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 218493016698 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 218493016699 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218493016701 8 probable transmembrane helices predicted for SBG3075 by TMHMM2.0 at aa 21-43, 78-100, 107-129, 134-156,411-433, 437-453, 458-477 and 487-506 218493016703 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 218493016704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493016705 inhibitor-cofactor binding pocket; inhibition site 218493016706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493016707 catalytic residue [active] 218493016710 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 218493016711 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218493016712 glutamine binding [chemical binding]; other site 218493016713 catalytic triad [active] 218493016718 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 218493016719 cell filamentation protein Fic; Provisional; Region: PRK10347 218493016721 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 218493016722 signal peptide predicted for SBG3079 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 24 and 25 218493016723 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 218493016724 substrate binding site [chemical binding]; other site 218493016727 signal peptide predicted for SBG3080 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.842 between residues 32 and 33 218493016728 putative transporter; Provisional; Region: PRK03699 218493016729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493016730 putative substrate translocation pore; other site 218493016731 12 probable transmembrane helices predicted for SBG3080 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121,134-156, 161-183, 204-226, 246-268, 273-292, 297-319,332-354 and 359-381 218493016735 nitrite reductase subunit NirD; Provisional; Region: PRK14989 218493016736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493016737 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218493016738 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218493016739 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218493016746 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 218493016748 nitrite transporter NirC; Provisional; Region: PRK11562 218493016749 signal peptide predicted for SBG3084 by SignalP 2.0 HMM (Signal peptide probabilty 0.697) with cleavage site probability 0.597 between residues 34 and 35 218493016751 6 probable transmembrane helices predicted for SBG3084 by TMHMM2.0 at aa 25-47, 67-89, 109-131, 146-168,181-200 and 226-248 218493016754 siroheme synthase; Provisional; Region: cysG; PRK10637 218493016755 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 218493016756 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 218493016757 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 218493016758 active site 218493016759 SAM binding site [chemical binding]; other site 218493016760 homodimer interface [polypeptide binding]; other site 218493016765 signal peptide predicted for SBG3086 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 24 and 25 218493016766 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218493016768 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 218493016769 signal peptide predicted for SBG3087 by SignalP 2.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.475 between residues 19 and 20 218493016771 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 218493016772 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218493016773 active site 218493016774 HIGH motif; other site 218493016775 dimer interface [polypeptide binding]; other site 218493016776 KMSKS motif; other site 218493016779 phosphoglycolate phosphatase; Provisional; Region: PRK13222 218493016780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493016781 motif II; other site 218493016783 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218493016784 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 218493016785 substrate binding site [chemical binding]; other site 218493016786 hexamer interface [polypeptide binding]; other site 218493016787 metal binding site [ion binding]; metal-binding site 218493016791 DNA adenine methylase; Provisional; Region: PRK10904 218493016794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 218493016795 cell division protein DamX; Validated; Region: PRK10905 218493016797 1 probable transmembrane helix predicted for SBG3092 by TMHMM2.0 at aa 93-115 218493016798 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 218493016799 active site 218493016800 dimer interface [polypeptide binding]; other site 218493016801 metal binding site [ion binding]; metal-binding site 218493016803 shikimate kinase; Reviewed; Region: aroK; PRK00131 218493016804 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218493016805 ADP binding site [chemical binding]; other site 218493016806 magnesium binding site [ion binding]; other site 218493016807 putative shikimate binding site; other site 218493016811 signal peptide predicted for SBG3095 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.768 between residues 18 and 19 218493016812 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 218493016813 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218493016814 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218493016819 1 probable transmembrane helix predicted for SBG3096 by TMHMM2.0 at aa 20-42 218493016820 signal peptide predicted for SBG3098 by SignalP 2.0 HMM (Signal peptide probabilty 0.853) with cleavage site probability 0.469 between residues 32 and 33 218493016821 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 218493016822 Transglycosylase; Region: Transgly; pfam00912 218493016823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218493016824 1 probable transmembrane helix predicted for SBG3098 by TMHMM2.0 at aa 12-34 218493016828 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 218493016829 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218493016830 ADP-ribose binding site [chemical binding]; other site 218493016831 dimer interface [polypeptide binding]; other site 218493016832 active site 218493016833 nudix motif; other site 218493016834 metal binding site [ion binding]; metal-binding site 218493016837 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 218493016838 signal peptide predicted for SBG3100 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.778 between residues 18 and 19 218493016840 5 probable transmembrane helices predicted for SBG3100 by TMHMM2.0 at aa 4-22, 202-221, 225-247, 336-358 and 652-674 218493016842 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 218493016843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493016844 motif II; other site 218493016846 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493016847 RNA binding surface [nucleotide binding]; other site 218493016849 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 218493016850 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 218493016851 dimerization interface [polypeptide binding]; other site 218493016852 domain crossover interface; other site 218493016853 redox-dependent activation switch; other site 218493016855 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 218493016856 11 probable transmembrane helices predicted for SBG3104 by TMHMM2.0 at aa 12-34, 39-61, 66-84, 99-118,138-160, 183-200, 213-235, 250-269, 281-303, 318-340 and 353-375 218493016858 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 218493016859 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 218493016860 active site 218493016861 substrate-binding site [chemical binding]; other site 218493016862 metal-binding site [ion binding] 218493016863 ATP binding site [chemical binding]; other site 218493016867 signal peptide predicted for SBG3106 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.322 between residues 34 and 35 218493016868 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 218493016869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493016870 dimerization interface [polypeptide binding]; other site 218493016871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493016872 dimer interface [polypeptide binding]; other site 218493016873 phosphorylation site [posttranslational modification] 218493016874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493016875 ATP binding site [chemical binding]; other site 218493016876 G-X-G motif; other site 218493016880 1 probable transmembrane helix predicted for SBG3106 by TMHMM2.0 at aa 12-34 218493016882 osmolarity response regulator; Provisional; Region: ompR; PRK09468 218493016883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493016884 active site 218493016885 phosphorylation site [posttranslational modification] 218493016886 intermolecular recognition site; other site 218493016887 dimerization interface [polypeptide binding]; other site 218493016888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493016889 DNA binding site [nucleotide binding] 218493016892 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 218493016893 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 218493016894 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218493016899 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 218493016900 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 218493016901 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 218493016902 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 218493016903 RNA binding site [nucleotide binding]; other site 218493016905 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 218493016907 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 218493016908 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 218493016909 G1 box; other site 218493016910 GTP/Mg2+ binding site [chemical binding]; other site 218493016911 Switch I region; other site 218493016912 G2 box; other site 218493016913 G3 box; other site 218493016914 Switch II region; other site 218493016915 G4 box; other site 218493016916 G5 box; other site 218493016917 Nucleoside recognition; Region: Gate; pfam07670 218493016918 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 218493016919 Nucleoside recognition; Region: Gate; pfam07670 218493016923 10 probable transmembrane helices predicted for SBG3111 by TMHMM2.0 at aa 277-299, 309-331, 344-366,386-408, 429-447, 451-473, 510-532, 663-685, 692-714 and 720-742 218493016929 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 218493016931 hypothetical protein; Provisional; Region: PRK09956 218493016932 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 218493016934 carboxylesterase BioH; Provisional; Region: PRK10349 218493016935 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 218493016937 DNA utilization protein GntX; Provisional; Region: PRK11595 218493016938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493016939 active site 218493016942 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 218493016943 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 218493016944 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 218493016948 high-affinity gluconate transporter; Provisional; Region: PRK14984 218493016949 gluconate transporter; Region: gntP; TIGR00791 218493016950 signal peptide predicted for SBG3117 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.401 between residues 23 and 24 218493016952 10 probable transmembrane helices predicted for SBG3117 by TMHMM2.0 at aa 7-27, 37-59, 80-98, 103-125,159-181, 242-264, 277-296, 328-350, 362-384 and 399-421 218493016954 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 218493016955 signal peptide predicted for SBG3118 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.763 between residues 22 and 23 218493016956 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 218493016958 maltodextrin phosphorylase; Provisional; Region: PRK14985 218493016959 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 218493016960 active site pocket [active] 218493016963 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218493016965 1 probable transmembrane helix predicted for SBG3121 by TMHMM2.0 at aa 209-231 218493016966 signal peptide predicted for SBG3122 by SignalP 2.0 HMM (Signal peptide probabilty 0.658) with cleavage site probability 0.563 between residues 22 and 23 218493016967 3 probable transmembrane helices predicted for SBG3122 by TMHMM2.0 at aa 7-29, 44-66 and 78-100 218493016968 transcriptional regulator MalT; Provisional; Region: PRK04841 218493016969 AAA ATPase domain; Region: AAA_16; pfam13191 218493016970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493016971 DNA binding residues [nucleotide binding] 218493016972 dimerization interface [polypeptide binding]; other site 218493016975 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 218493016976 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218493016977 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493016981 intramembrane serine protease GlpG; Provisional; Region: PRK10907 218493016982 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 218493016983 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 218493016985 6 probable transmembrane helices predicted for SBG3125 by TMHMM2.0 at aa 98-120, 140-162, 169-188,192-214, 223-245 and 250-272 218493016987 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 218493016988 active site residue [active] 218493016990 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 218493016994 glycogen phosphorylase; Provisional; Region: PRK14986 218493016995 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 218493016996 homodimer interface [polypeptide binding]; other site 218493016997 active site pocket [active] 218493017000 glycogen synthase; Provisional; Region: glgA; PRK00654 218493017001 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 218493017002 ADP-binding pocket [chemical binding]; other site 218493017003 homodimer interface [polypeptide binding]; other site 218493017007 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 218493017008 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 218493017009 ligand binding site; other site 218493017010 oligomer interface; other site 218493017011 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 218493017012 dimer interface [polypeptide binding]; other site 218493017013 N-terminal domain interface [polypeptide binding]; other site 218493017014 sulfate 1 binding site; other site 218493017020 glycogen debranching enzyme; Provisional; Region: PRK03705 218493017021 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 218493017022 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 218493017023 active site 218493017024 catalytic site [active] 218493017027 glycogen branching enzyme; Provisional; Region: PRK05402 218493017028 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 218493017029 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 218493017030 active site 218493017031 catalytic site [active] 218493017032 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 218493017036 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 218493017037 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218493017041 low affinity gluconate transporter; Provisional; Region: PRK10472 218493017042 signal peptide predicted for SBG3134 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.292 between residues 38 and 39 218493017043 gluconate transporter; Region: gntP; TIGR00791 218493017044 13 probable transmembrane helices predicted for SBG3134 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 104-126,146-168, 175-197, 228-250, 262-284, 299-321, 328-350,354-373, 386-408 and 423-445 218493017047 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 218493017048 ATP-binding site [chemical binding]; other site 218493017049 Gluconate-6-phosphate binding site [chemical binding]; other site 218493017052 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 218493017053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493017054 DNA binding site [nucleotide binding] 218493017055 domain linker motif; other site 218493017056 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218493017057 putative ligand binding site [chemical binding]; other site 218493017058 putative dimerization interface [polypeptide binding]; other site 218493017062 Pirin-related protein [General function prediction only]; Region: COG1741 218493017063 Pirin; Region: Pirin; pfam02678 218493017065 putative oxidoreductase; Provisional; Region: PRK10206 218493017066 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218493017067 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218493017071 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493017072 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218493017073 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493017074 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 218493017075 substrate binding site [chemical binding]; other site 218493017076 dimer interface [polypeptide binding]; other site 218493017077 ATP binding site [chemical binding]; other site 218493017081 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 218493017084 signal peptide predicted for SBG3141 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.732 between residues 27 and 28 218493017085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 218493017086 Protein of unknown function, DUF606; Region: DUF606; pfam04657 218493017087 10 probable transmembrane helices predicted for SBG3141 by TMHMM2.0 at aa 7-26, 41-60, 80-97, 102-124,137-159, 164-186, 199-221, 231-253, 255-276 and 286-308 218493017089 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 218493017090 active site 218493017091 substrate binding pocket [chemical binding]; other site 218493017092 homodimer interaction site [polypeptide binding]; other site 218493017095 Protein of unknown function (DUF796); Region: DUF796; cl01226 218493017097 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 218493017098 signal peptide predicted for SBG3144 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 24 and 25 218493017099 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 218493017102 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 218493017103 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 218493017104 putative active site [active] 218493017105 catalytic site [active] 218493017106 putative metal binding site [ion binding]; other site 218493017108 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218493017109 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218493017110 Walker A/P-loop; other site 218493017111 ATP binding site [chemical binding]; other site 218493017112 Q-loop/lid; other site 218493017113 ABC transporter signature motif; other site 218493017114 Walker B; other site 218493017115 D-loop; other site 218493017116 H-loop/switch region; other site 218493017117 TOBE domain; Region: TOBE_2; pfam08402 218493017122 signal peptide predicted for SBG3147 by SignalP 2.0 HMM (Signal peptide probabilty 0.862) with cleavage site probability 0.606 between residues 33 and 34 218493017123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218493017124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493017125 dimer interface [polypeptide binding]; other site 218493017126 conserved gate region; other site 218493017127 putative PBP binding loops; other site 218493017128 ABC-ATPase subunit interface; other site 218493017130 6 probable transmembrane helices predicted for SBG3147 by TMHMM2.0 at aa 7-29, 82-104, 111-130, 145-162,200-222 and 245-267 218493017132 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218493017133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493017134 putative PBP binding loops; other site 218493017135 dimer interface [polypeptide binding]; other site 218493017136 ABC-ATPase subunit interface; other site 218493017138 6 probable transmembrane helices predicted for SBG3148 by TMHMM2.0 at aa 12-34, 75-97, 110-130, 157-179,206-228 and 266-288 218493017140 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 218493017141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218493017142 signal peptide predicted for SBG3149 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493017145 1 probable transmembrane helix predicted for SBG3149 by TMHMM2.0 at aa 7-29 218493017146 signal peptide predicted for SBG3150 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 22 and 23 218493017147 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 218493017148 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 218493017149 Walker A/P-loop; other site 218493017150 ATP binding site [chemical binding]; other site 218493017151 Q-loop/lid; other site 218493017152 ABC transporter signature motif; other site 218493017153 Walker B; other site 218493017154 D-loop; other site 218493017155 H-loop/switch region; other site 218493017159 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 218493017160 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 218493017161 Walker A/P-loop; other site 218493017162 ATP binding site [chemical binding]; other site 218493017163 Q-loop/lid; other site 218493017164 ABC transporter signature motif; other site 218493017165 Walker B; other site 218493017166 D-loop; other site 218493017167 H-loop/switch region; other site 218493017171 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 218493017172 signal peptide predicted for SBG3153 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.397 between residues 25 and 26 218493017173 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 218493017174 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 218493017175 TM-ABC transporter signature motif; other site 218493017176 9 probable transmembrane helices predicted for SBG3153 by TMHMM2.0 at aa 7-29, 44-61, 91-108, 118-140,161-183, 261-283, 315-337, 352-374 and 381-400 218493017178 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218493017179 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 218493017180 TM-ABC transporter signature motif; other site 218493017181 8 probable transmembrane helices predicted for SBG3154 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124,153-175, 207-229, 244-266 and 282-301 218493017183 signal peptide predicted for SBG3155 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 23 and 24 218493017184 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 218493017185 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 218493017186 dimerization interface [polypeptide binding]; other site 218493017187 ligand binding site [chemical binding]; other site 218493017189 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 218493017191 signal peptide predicted for SBG3157 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493017192 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 218493017193 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 218493017194 dimerization interface [polypeptide binding]; other site 218493017195 ligand binding site [chemical binding]; other site 218493017197 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493017198 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 218493017199 11 probable transmembrane helices predicted for SBG3158 by TMHMM2.0 at aa 26-48, 53-75, 95-117,132-154, 163-181, 196-215, 235-257, 277-299, 319-341,346-363 and 390-412 218493017201 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 218493017202 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218493017203 inhibitor-cofactor binding pocket; inhibition site 218493017204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493017205 catalytic residue [active] 218493017208 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218493017209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493017210 DNA-binding site [nucleotide binding]; DNA binding site 218493017211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493017212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493017213 homodimer interface [polypeptide binding]; other site 218493017214 catalytic residue [active] 218493017217 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 218493017218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218493017219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218493017220 DNA binding residues [nucleotide binding] 218493017225 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 218493017226 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 218493017228 4 probable transmembrane helices predicted for SBG3162 by TMHMM2.0 at aa 71-93, 223-245, 266-288 and 323-342 218493017229 cell division protein FtsE; Provisional; Region: PRK10908 218493017230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493017231 Walker A/P-loop; other site 218493017232 ATP binding site [chemical binding]; other site 218493017233 Q-loop/lid; other site 218493017234 ABC transporter signature motif; other site 218493017235 Walker B; other site 218493017236 D-loop; other site 218493017237 H-loop/switch region; other site 218493017241 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 218493017242 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 218493017243 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218493017244 P loop; other site 218493017245 GTP binding site [chemical binding]; other site 218493017250 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 218493017251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493017252 S-adenosylmethionine binding site [chemical binding]; other site 218493017255 hypothetical protein; Provisional; Region: PRK10910 218493017257 2 probable transmembrane helices predicted for SBG3166 by TMHMM2.0 at aa 4-23 and 30-52 218493017258 signal peptide predicted for SBG3167 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.780 between residues 18 and 19 218493017259 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 218493017260 1 probable transmembrane helix predicted for SBG3167 by TMHMM2.0 at aa 5-24 218493017261 Predicted membrane protein [Function unknown]; Region: COG3714 218493017263 6 probable transmembrane helices predicted for SBG3168 by TMHMM2.0 at aa 28-45, 50-72, 77-96, 101-123,130-152 and 156-178 218493017264 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 218493017265 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218493017266 metal-binding site [ion binding] 218493017267 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493017268 Soluble P-type ATPase [General function prediction only]; Region: COG4087 218493017271 5 probable transmembrane helices predicted for SBG3169 by TMHMM2.0 at aa 150-172, 192-214, 353-375,390-412 and 693-715 218493017279 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 218493017280 signal peptide predicted for SBG3170 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.235 between residues 31 and 32 218493017281 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218493017282 dimer interface [polypeptide binding]; other site 218493017283 ligand binding site [chemical binding]; other site 218493017284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493017285 dimerization interface [polypeptide binding]; other site 218493017286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493017287 dimer interface [polypeptide binding]; other site 218493017288 putative CheW interface [polypeptide binding]; other site 218493017289 2 probable transmembrane helices predicted for SBG3170 by TMHMM2.0 at aa 10-32 and 193-215 218493017294 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 218493017295 CPxP motif; other site 218493017298 hypothetical protein; Provisional; Region: PRK11212 218493017299 6 probable transmembrane helices predicted for SBG3172 by TMHMM2.0 at aa 13-35, 45-64, 71-93, 108-130,142-164 and 184-206 218493017301 hypothetical protein; Provisional; Region: PRK11615 218493017302 signal peptide predicted for SBG3173 by SignalP 2.0 HMM (Signal peptide probabilty 0.771) with cleavage site probability 0.358 between residues 19 and 20 218493017304 major facilitator superfamily transporter; Provisional; Region: PRK05122 218493017305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493017306 putative substrate translocation pore; other site 218493017307 12 probable transmembrane helices predicted for SBG3174 by TMHMM2.0 at aa 19-41, 51-73, 85-107,122-144, 151-173, 177-199, 220-242, 252-271, 278-300,310-332, 339-361 and 366-388 218493017309 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 218493017310 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218493017311 8 probable transmembrane helices predicted for SBG3175 by TMHMM2.0 at aa 12-29, 33-55, 62-84, 141-163,198-220, 224-246, 253-275 and 295-317 218493017313 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 218493017314 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 218493017316 nickel responsive regulator; Provisional; Region: PRK02967 218493017317 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 218493017320 signal peptide predicted for SBG3178 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.818 between residues 40 and 41 218493017321 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 218493017322 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218493017323 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 218493017324 6 probable transmembrane helices predicted for SBG3178 by TMHMM2.0 at aa 25-47, 174-196, 225-244,259-281, 288-307 and 344-366 218493017327 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218493017328 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218493017329 Walker A/P-loop; other site 218493017330 ATP binding site [chemical binding]; other site 218493017331 Q-loop/lid; other site 218493017332 ABC transporter signature motif; other site 218493017333 Walker B; other site 218493017334 D-loop; other site 218493017335 H-loop/switch region; other site 218493017336 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218493017337 Walker A/P-loop; other site 218493017338 ATP binding site [chemical binding]; other site 218493017339 Q-loop/lid; other site 218493017340 ABC transporter signature motif; other site 218493017341 Walker B; other site 218493017342 D-loop; other site 218493017343 H-loop/switch region; other site 218493017344 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218493017345 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 218493017346 5 probable transmembrane helices predicted for SBG3179 by TMHMM2.0 at aa 720-742, 771-793, 798-820,827-844 and 887-909 218493017353 signal peptide predicted for SBG3180 by SignalP 2.0 HMM (Signal peptide probabilty 0.705) with cleavage site probability 0.547 between residues 22 and 23 218493017354 HlyD family secretion protein; Region: HlyD; pfam00529 218493017355 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493017356 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493017358 1 probable transmembrane helix predicted for SBG3180 by TMHMM2.0 at aa 7-26 218493017359 Predicted flavoproteins [General function prediction only]; Region: COG2081 218493017360 signal peptide predicted for SBG3181 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.816 between residues 22 and 23 218493017361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493017363 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218493017364 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218493017365 9 probable transmembrane helices predicted for SBG3182 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145,155-177, 207-224, 234-256, 380-402 and 472-494 218493017368 universal stress protein UspB; Provisional; Region: PRK04960 218493017369 2 probable transmembrane helices predicted for SBG3183 by TMHMM2.0 at aa 5-24 and 90-109 218493017370 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218493017371 Ligand Binding Site [chemical binding]; other site 218493017373 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 218493017374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493017375 putative substrate translocation pore; other site 218493017376 POT family; Region: PTR2; pfam00854 218493017377 14 probable transmembrane helices predicted for SBG3185 by TMHMM2.0 at aa 20-42, 52-74, 83-102,107-124, 145-167, 171-193, 214-233, 237-255, 268-290,314-336, 349-371, 386-408, 415-437 and 457-479 218493017380 Predicted transcriptional regulator [Transcription]; Region: COG1959 218493017381 Transcriptional regulator; Region: Rrf2; pfam02082 218493017384 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 218493017385 signal peptide predicted for SBG3187 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.472 between residues 20 and 21 218493017386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493017387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493017390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493017391 S-adenosylmethionine binding site [chemical binding]; other site 218493017393 oligopeptidase A; Provisional; Region: PRK10911 218493017394 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 218493017395 active site 218493017396 Zn binding site [ion binding]; other site 218493017399 signal peptide predicted for SBG3190 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 20 and 21 218493017400 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 218493017401 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218493017402 active site 218493017404 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 218493017408 glutathione reductase; Validated; Region: PRK06116 218493017409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218493017410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493017411 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218493017416 signal peptide predicted for SBG3193 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 20 and 21 218493017417 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 218493017418 active site 218493017419 homodimer interface [polypeptide binding]; other site 218493017420 homotetramer interface [polypeptide binding]; other site 218493017424 1 probable transmembrane helix predicted for SBG3193 by TMHMM2.0 at aa 7-29 218493017425 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 218493017426 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 218493017427 11 probable transmembrane helices predicted for SBG3194 by TMHMM2.0 at aa 20-42, 52-74, 87-109,163-185, 227-249, 264-281, 294-316, 331-350, 357-374,379-398 and 419-438 218493017430 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 218493017431 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493017432 substrate binding site [chemical binding]; other site 218493017433 ATP binding site [chemical binding]; other site 218493017436 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 218493017437 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 218493017438 putative active site [active] 218493017439 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218493017440 dimer interface [polypeptide binding]; other site 218493017441 active site 218493017444 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218493017445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493017446 DNA-binding site [nucleotide binding]; DNA binding site 218493017447 UTRA domain; Region: UTRA; pfam07702 218493017450 trehalase; Provisional; Region: treF; PRK13270 218493017451 Trehalase; Region: Trehalase; pfam01204 218493017455 1 probable transmembrane helix predicted for SBG3199 by TMHMM2.0 at aa 337-359 218493017456 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 218493017457 catalytic residue [active] 218493017458 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493017459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493017460 DNA binding residues [nucleotide binding] 218493017461 dimerization interface [polypeptide binding]; other site 218493017464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493017465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493017466 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 218493017467 putative effector binding pocket; other site 218493017468 putative dimerization interface [polypeptide binding]; other site 218493017472 inner membrane protein YhjD; Region: TIGR00766 218493017474 6 probable transmembrane helices predicted for SBG3203 by TMHMM2.0 at aa 80-102, 135-157, 191-213,233-255, 267-289 and 304-326 218493017475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493017476 metabolite-proton symporter; Region: 2A0106; TIGR00883 218493017477 putative substrate translocation pore; other site 218493017479 11 probable transmembrane helices predicted for SBG3204 by TMHMM2.0 at aa 24-46, 66-88, 109-131,166-188, 195-217, 247-269, 290-312, 322-341, 348-370,380-402 and 409-431 218493017482 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 218493017483 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218493017485 1 probable transmembrane helix predicted for SBG3205 by TMHMM2.0 at aa 7-29 218493017486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493017488 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493017489 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218493017490 substrate binding site [chemical binding]; other site 218493017491 ATP binding site [chemical binding]; other site 218493017494 signal peptide predicted for SBG3208 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 24 and 25 218493017495 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218493017496 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218493017500 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 218493017501 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218493017503 9 probable transmembrane helices predicted for SBG3209 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163,184-206, 216-238, 289-311, 326-348 and 353-375 218493017506 signal peptide predicted for SBG3210 by SignalP 2.0 HMM (Signal peptide probabilty 0.812) with cleavage site probability 0.307 between residues 37 and 38 218493017507 putative diguanylate cyclase; Provisional; Region: PRK13561 218493017508 HAMP domain; Region: HAMP; pfam00672 218493017509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493017510 metal binding site [ion binding]; metal-binding site 218493017511 active site 218493017512 I-site; other site 218493017513 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493017517 2 probable transmembrane helices predicted for SBG3210 by TMHMM2.0 at aa 13-35 and 156-178 218493017518 signal peptide predicted for SBG3211 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.777 between residues 34 and 35 218493017519 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 218493017520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493017521 TPR motif; other site 218493017522 binding surface 218493017523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493017524 binding surface 218493017525 TPR motif; other site 218493017526 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 218493017532 signal peptide predicted for SBG3212 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.941 between residues 22 and 23 218493017533 endo-1,4-D-glucanase; Provisional; Region: PRK11097 218493017536 1 probable transmembrane helix predicted for SBG3212 by TMHMM2.0 at aa 7-29 218493017537 cellulose synthase regulator protein; Provisional; Region: PRK11114 218493017538 signal peptide predicted for SBG3213 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.899 between residues 25 and 26 218493017539 2 probable transmembrane helices predicted for SBG3213 by TMHMM2.0 at aa 7-29 and 738-760 218493017542 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 218493017543 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 218493017544 DXD motif; other site 218493017545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218493017546 PilZ domain; Region: PilZ; pfam07238 218493017548 10 probable transmembrane helices predicted for SBG3214 by TMHMM2.0 at aa 28-50, 150-169, 173-190,197-216, 229-251, 522-541, 545-567, 588-610, 633-655 and 668-690 218493017553 cell division protein; Provisional; Region: PRK10037 218493017554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218493017556 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 218493017557 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 218493017558 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 218493017559 1 probable transmembrane helix predicted for SBG3217 by TMHMM2.0 at aa 7-29 218493017560 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 218493017561 4 probable transmembrane helices predicted for SBG3218 by TMHMM2.0 at aa 33-55, 68-85, 114-133 and 140-162 218493017564 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 218493017565 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218493017566 11 probable transmembrane helices predicted for SBG3219 by TMHMM2.0 at aa 29-51, 56-73, 104-126,146-168, 175-197, 212-234, 255-277, 303-325, 351-373,377-399 and 412-431 218493017569 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 218493017570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493017571 Walker A/P-loop; other site 218493017572 ATP binding site [chemical binding]; other site 218493017573 Q-loop/lid; other site 218493017574 ABC transporter signature motif; other site 218493017575 Walker B; other site 218493017576 D-loop; other site 218493017577 H-loop/switch region; other site 218493017578 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218493017583 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 218493017584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218493017585 Walker A/P-loop; other site 218493017586 ATP binding site [chemical binding]; other site 218493017587 Q-loop/lid; other site 218493017588 ABC transporter signature motif; other site 218493017589 Walker B; other site 218493017590 D-loop; other site 218493017591 H-loop/switch region; other site 218493017592 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218493017597 dipeptide transporter; Provisional; Region: PRK10913 218493017598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493017599 dimer interface [polypeptide binding]; other site 218493017600 conserved gate region; other site 218493017601 putative PBP binding loops; other site 218493017602 ABC-ATPase subunit interface; other site 218493017604 5 probable transmembrane helices predicted for SBG3222 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 218493017605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218493017606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493017607 dimer interface [polypeptide binding]; other site 218493017608 conserved gate region; other site 218493017609 putative PBP binding loops; other site 218493017610 ABC-ATPase subunit interface; other site 218493017612 6 probable transmembrane helices predicted for SBG3223 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 202-221,258-280 and 309-331 218493017614 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218493017615 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 218493017616 peptide binding site [polypeptide binding]; other site 218493017619 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 218493017620 13 probable transmembrane helices predicted for SBG3225 by TMHMM2.0 at aa 20-42, 47-69, 76-98,103-125, 132-154, 169-191, 198-220, 230-252, 287-309,319-341, 348-370, 380-402 and 409-431 218493017622 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 218493017623 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493017624 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493017625 DNA binding site [nucleotide binding] 218493017626 domain linker motif; other site 218493017627 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 218493017628 putative dimerization interface [polypeptide binding]; other site 218493017629 putative ligand binding site [chemical binding]; other site 218493017633 1 probable transmembrane helix predicted for SBG3227 by TMHMM2.0 at aa 67-89 218493017634 phosphoethanolamine transferase; Provisional; Region: PRK11560 218493017635 signal peptide predicted for SBG3228 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.991 between residues 37 and 38 218493017636 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 218493017637 Sulfatase; Region: Sulfatase; pfam00884 218493017639 5 probable transmembrane helices predicted for SBG3228 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178 218493017641 fimbrial operon lpf 218493017642 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 218493017643 signal peptide predicted for SBG3229 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21 218493017645 Fimbrial protein; Region: Fimbrial; cl01416 218493017646 signal peptide predicted for SBG3230 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 24 and 25 218493017647 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 218493017648 signal peptide predicted for SBG3231 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 32 and 33 218493017649 PapC N-terminal domain; Region: PapC_N; pfam13954 218493017650 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493017651 PapC C-terminal domain; Region: PapC_C; pfam13953 218493017654 signal peptide predicted for SBG3232 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 23 and 24 218493017655 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 218493017656 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493017657 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493017661 1 probable transmembrane helix predicted for SBG3232 by TMHMM2.0 at aa 7-29 218493017662 signal peptide predicted for SBG3233 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25 218493017663 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 218493017665 this CDS carries a frameshift mutation following codon 67 and lacks a 3' end 218493017666 2 probable transmembrane helices predicted for SBG3234 by TMHMM2.0 at aa 5-27 and 32-54 218493017667 signal peptide predicted for SBG3234 by SignalP 2.0 HMM (Signal peptide probabilty 0.874) with cleavage site probability 0.684 between residues 42 and 43 218493017668 2 probable transmembrane helices predicted for SBG3235 by TMHMM2.0 at aa 11-33 and 48-70 218493017669 signal peptide predicted for SBG3235 by SignalP 2.0 HMM (Signal peptide probabilty 0.868) with cleavage site probability 0.426 between residues 29 and 30 218493017670 1 probable transmembrane helix predicted for SBG3236 by TMHMM2.0 at aa 21-43 218493017671 signal peptide predicted for SBG3237 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.533 between residues 30 and 31 218493017672 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 218493017673 1 probable transmembrane helix predicted for SBG3237 by TMHMM2.0 at aa 12-31 218493017674 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 218493017677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493017678 Coenzyme A binding pocket [chemical binding]; other site 218493017679 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218493017681 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 218493017682 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 218493017683 molybdopterin cofactor binding site [chemical binding]; other site 218493017684 substrate binding site [chemical binding]; other site 218493017685 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 218493017686 molybdopterin cofactor binding site; other site 218493017692 putative outer membrane lipoprotein; Provisional; Region: PRK10510 218493017693 signal peptide predicted for SBG3242 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.822 between residues 20 and 21 218493017694 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218493017695 ligand binding site [chemical binding]; other site 218493017696 3 probable transmembrane helices predicted for SBG3242 by TMHMM2.0 at aa 5-27, 37-55 and 62-84 218493017702 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 218493017703 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 218493017704 dimerization interface [polypeptide binding]; other site 218493017705 ligand binding site [chemical binding]; other site 218493017706 NADP binding site [chemical binding]; other site 218493017707 catalytic site [active] 218493017711 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 218493017712 1 probable transmembrane helix predicted for SBG3244 by TMHMM2.0 at aa 10-27 218493017715 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493017716 DNA-binding site [nucleotide binding]; DNA binding site 218493017717 RNA-binding motif; other site 218493017720 signal peptide predicted for SBG3248 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21 218493017722 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 218493017723 DALR anticodon binding domain; Region: DALR_1; pfam05746 218493017726 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 218493017727 dimer interface [polypeptide binding]; other site 218493017728 motif 1; other site 218493017729 active site 218493017730 motif 2; other site 218493017731 motif 3; other site 218493017734 signal peptide predicted for SBG3251 by SignalP 2.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.331 between residues 21 and 22 218493017735 YsaB-like lipoprotein; Region: YsaB; pfam13983 218493017737 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 218493017738 Acyltransferase family; Region: Acyl_transf_3; pfam01757 218493017740 10 probable transmembrane helices predicted for SBG3252 by TMHMM2.0 at aa 13-30, 45-67, 79-101,114-136, 143-160, 175-194, 201-223, 233-255, 267-289 and 304-321 218493017741 Predicted membrane protein [Function unknown]; Region: COG4682 218493017742 yiaA/B two helix domain; Region: YiaAB; pfam05360 218493017743 yiaA/B two helix domain; Region: YiaAB; cl01759 218493017745 3 probable transmembrane helices predicted for SBG3253 by TMHMM2.0 at aa 12-29, 39-58 and 70-92 218493017747 xylulokinase; Provisional; Region: PRK15027 218493017748 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 218493017749 N- and C-terminal domain interface [polypeptide binding]; other site 218493017750 active site 218493017751 MgATP binding site [chemical binding]; other site 218493017752 catalytic site [active] 218493017753 metal binding site [ion binding]; metal-binding site 218493017754 xylulose binding site [chemical binding]; other site 218493017755 homodimer interface [polypeptide binding]; other site 218493017761 xylose isomerase; Provisional; Region: PRK05474 218493017762 xylose isomerase; Region: xylose_isom_A; TIGR02630 218493017766 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 218493017767 putative dimerization interface [polypeptide binding]; other site 218493017768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218493017769 putative ligand binding site [chemical binding]; other site 218493017770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493017771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493017772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493017776 hypothetical protein; Provisional; Region: PRK10356 218493017777 signal peptide predicted for SBG3257 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.989 between residues 27 and 28 218493017778 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 218493017780 alpha-amylase; Reviewed; Region: malS; PRK09505 218493017781 signal peptide predicted for SBG3258 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.762 between residues 29 and 30 218493017782 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 218493017783 active site 218493017784 catalytic site [active] 218493017786 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 218493017787 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493017788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493017789 homodimer interface [polypeptide binding]; other site 218493017790 catalytic residue [active] 218493017792 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 218493017795 2 probable transmembrane helices predicted for SBG3261 by TMHMM2.0 at aa 23-45 and 70-92 218493017797 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 218493017798 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 218493017799 NAD(P) binding site [chemical binding]; other site 218493017800 catalytic residues [active] 218493017804 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218493017805 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218493017806 nucleotide binding site [chemical binding]; other site 218493017808 putative alcohol dehydrogenase; Provisional; Region: PRK09860 218493017809 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 218493017810 dimer interface [polypeptide binding]; other site 218493017811 active site 218493017812 metal binding site [ion binding]; metal-binding site 218493017816 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 218493017817 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 218493017818 G1 box; other site 218493017819 putative GEF interaction site [polypeptide binding]; other site 218493017820 GTP/Mg2+ binding site [chemical binding]; other site 218493017821 Switch I region; other site 218493017822 G2 box; other site 218493017823 G3 box; other site 218493017824 Switch II region; other site 218493017825 G4 box; other site 218493017826 G5 box; other site 218493017827 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 218493017828 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 218493017829 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 218493017830 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 218493017837 selenocysteine synthase; Provisional; Region: PRK04311 218493017838 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 218493017839 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 218493017840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218493017841 catalytic residue [active] 218493017843 putative glutathione S-transferase; Provisional; Region: PRK10357 218493017844 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 218493017845 putative C-terminal domain interface [polypeptide binding]; other site 218493017846 putative GSH binding site (G-site) [chemical binding]; other site 218493017847 putative dimer interface [polypeptide binding]; other site 218493017848 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 218493017849 dimer interface [polypeptide binding]; other site 218493017850 N-terminal domain interface [polypeptide binding]; other site 218493017851 putative substrate binding pocket (H-site) [chemical binding]; other site 218493017855 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 218493017856 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218493017857 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218493017858 putative active site [active] 218493017861 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 218493017862 active site 218493017863 catalytic residues [active] 218493017865 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 218493017866 Sulfatase; Region: Sulfatase; cl17466 218493017868 signal peptide predicted for SBG3271 by SignalP 2.0 HMM (Signal peptide probabilty 0.872) with cleavage site probability 0.765 between residues 49 and 50 218493017869 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 218493017870 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218493017871 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493017872 active site turn [active] 218493017873 phosphorylation site [posttranslational modification] 218493017875 11 probable transmembrane helices predicted for SBG3271 by TMHMM2.0 at aa 32-54, 74-96, 106-128,141-163, 183-205, 212-234, 244-266, 323-340, 345-367,374-396 and 401-423 218493017878 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 218493017879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493017880 FeS/SAM binding site; other site 218493017881 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 218493017883 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 218493017884 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 218493017885 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 218493017886 active site 218493017887 P-loop; other site 218493017888 phosphorylation site [posttranslational modification] 218493017889 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493017890 active site 218493017891 phosphorylation site [posttranslational modification] 218493017893 8 probable transmembrane helices predicted for SBG3273 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151,212-234, 244-263, 270-292 and 312-334 218493017897 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 218493017898 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218493017899 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218493017903 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 218493017904 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 218493017906 hypothetical protein; Provisional; Region: PRK11020 218493017907 L-lactate permease; Provisional; Region: PRK10420 218493017908 glycolate transporter; Provisional; Region: PRK09695 218493017909 12 probable transmembrane helices predicted for SBG3277 by TMHMM2.0 at aa 10-32, 39-58, 68-90,119-141, 156-178, 199-218, 244-266, 299-321, 368-387,407-424, 434-456 and 528-550 218493017912 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 218493017913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493017914 DNA-binding site [nucleotide binding]; DNA binding site 218493017915 FCD domain; Region: FCD; pfam07729 218493017919 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 218493017920 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 218493017921 active site 218493017922 substrate binding site [chemical binding]; other site 218493017923 FMN binding site [chemical binding]; other site 218493017924 putative catalytic residues [active] 218493017927 putative rRNA methylase; Provisional; Region: PRK10358 218493017929 serine acetyltransferase; Provisional; Region: cysE; PRK11132 218493017930 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 218493017931 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 218493017932 trimer interface [polypeptide binding]; other site 218493017933 active site 218493017934 substrate binding site [chemical binding]; other site 218493017935 CoA binding site [chemical binding]; other site 218493017942 signal peptide predicted for SBG3282 by SignalP 2.0 HMM (Signal peptide probabilty 0.814) with cleavage site probability 0.792 between residues 21 and 22 218493017943 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 218493017944 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 218493017945 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 218493017949 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 218493017950 SecA binding site; other site 218493017951 Preprotein binding site; other site 218493017953 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 218493017954 GSH binding site [chemical binding]; other site 218493017955 catalytic residues [active] 218493017958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218493017959 active site residue [active] 218493017961 1 probable transmembrane helix predicted for SBG3285 by TMHMM2.0 at aa 7-29 218493017962 phosphoglyceromutase; Provisional; Region: PRK05434 218493017963 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 218493017966 AmiB activator; Provisional; Region: PRK11637 218493017967 signal peptide predicted for SBG3287 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 42 and 43 218493017968 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 218493017969 Peptidase family M23; Region: Peptidase_M23; pfam01551 218493017970 1 probable transmembrane helix predicted for SBG3287 by TMHMM2.0 at aa 20-42 218493017972 signal peptide predicted for SBG3288 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 23 and 24 218493017973 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 218493017974 NodB motif; other site 218493017975 putative active site [active] 218493017976 putative catalytic site [active] 218493017977 Zn binding site [ion binding]; other site 218493017979 putative glycosyl transferase; Provisional; Region: PRK10073 218493017980 signal peptide predicted for SBG3289 by SignalP 2.0 HMM (Signal peptide probabilty 0.874) with cleavage site probability 0.597 between residues 30 and 31 218493017981 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218493017982 active site 218493017984 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 218493017985 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 218493017986 NAD(P) binding site [chemical binding]; other site 218493017990 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 218493017991 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 218493017992 substrate-cofactor binding pocket; other site 218493017993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493017994 catalytic residue [active] 218493017997 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 218493017998 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 218493017999 NADP binding site [chemical binding]; other site 218493018000 homopentamer interface [polypeptide binding]; other site 218493018001 substrate binding site [chemical binding]; other site 218493018002 active site 218493018004 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 218493018005 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218493018006 putative active site [active] 218493018008 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 218493018009 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218493018010 putative active site [active] 218493018013 O-antigen ligase RfaL; Provisional; Region: PRK15487 218493018014 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 218493018015 8 probable transmembrane helices predicted for SBG3295 by TMHMM2.0 at aa 21-52, 67-86, 127-149, 164-183,190-221, 231-248, 326-348 and 363-380 218493018017 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 218493018018 signal peptide predicted for SBG3296 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.675 between residues 22 and 23 218493018019 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218493018021 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 218493018022 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 218493018024 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 218493018025 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 218493018026 Ligand binding site; other site 218493018027 metal-binding site 218493018028 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 218493018032 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 218493018033 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 218493018034 Ligand binding site; other site 218493018035 metal-binding site 218493018036 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 218493018039 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 218493018040 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 218493018041 putative ADP-binding pocket [chemical binding]; other site 218493018043 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 218493018045 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 218493018047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218493018048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218493018051 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 218493018052 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218493018053 putative active site [active] 218493018055 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 218493018056 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 218493018057 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218493018060 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 218493018061 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 218493018062 active site 218493018063 (T/H)XGH motif; other site 218493018065 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 218493018066 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 218493018067 DNA binding site [nucleotide binding] 218493018068 catalytic residue [active] 218493018069 H2TH interface [polypeptide binding]; other site 218493018070 putative catalytic residues [active] 218493018071 turnover-facilitating residue; other site 218493018072 intercalation triad [nucleotide binding]; other site 218493018073 8OG recognition residue [nucleotide binding]; other site 218493018074 putative reading head residues; other site 218493018075 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218493018076 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218493018081 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 218493018084 hypothetical protein; Reviewed; Region: PRK00024 218493018085 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218493018086 MPN+ (JAMM) motif; other site 218493018087 Zinc-binding site [ion binding]; other site 218493018090 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 218493018091 Flavoprotein; Region: Flavoprotein; pfam02441 218493018092 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 218493018096 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218493018097 trimer interface [polypeptide binding]; other site 218493018098 active site 218493018100 division inhibitor protein; Provisional; Region: slmA; PRK09480 218493018101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493018104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218493018105 active site 218493018108 ribonuclease PH; Reviewed; Region: rph; PRK00173 218493018109 Ribonuclease PH; Region: RNase_PH_bact; cd11362 218493018110 hexamer interface [polypeptide binding]; other site 218493018111 active site 218493018115 hypothetical protein; Provisional; Region: PRK11820 218493018116 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 218493018117 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 218493018120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493018121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493018122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218493018123 dimerization interface [polypeptide binding]; other site 218493018126 signal peptide predicted for SBG3318 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22 218493018127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218493018129 Predicted membrane protein [Function unknown]; Region: COG2860 218493018130 UPF0126 domain; Region: UPF0126; pfam03458 218493018131 UPF0126 domain; Region: UPF0126; pfam03458 218493018133 7 probable transmembrane helices predicted for SBG3319 by TMHMM2.0 at aa 5-22, 29-51, 64-81, 88-109,114-136, 148-167 and 172-189 218493018135 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 218493018136 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 218493018137 nucleotide binding pocket [chemical binding]; other site 218493018138 K-X-D-G motif; other site 218493018139 catalytic site [active] 218493018140 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218493018146 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 218493018147 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 218493018148 catalytic site [active] 218493018149 G-X2-G-X-G-K; other site 218493018153 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 218493018155 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 218493018156 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218493018157 Zn2+ binding site [ion binding]; other site 218493018158 Mg2+ binding site [ion binding]; other site 218493018159 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218493018160 synthetase active site [active] 218493018161 NTP binding site [chemical binding]; other site 218493018162 metal binding site [ion binding]; metal-binding site 218493018163 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 218493018164 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218493018169 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 218493018170 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218493018171 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 218493018173 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 218493018174 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 218493018175 generic binding surface II; other site 218493018176 ssDNA binding site; other site 218493018177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493018178 ATP binding site [chemical binding]; other site 218493018179 putative Mg++ binding site [ion binding]; other site 218493018180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493018181 nucleotide binding region [chemical binding]; other site 218493018182 ATP-binding site [chemical binding]; other site 218493018187 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 218493018188 9 probable transmembrane helices predicted for SBG3326 by TMHMM2.0 at aa 70-87, 94-116, 162-184, 213-235,245-267, 274-292, 302-324, 337-359 and 374-396 218493018190 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 218493018193 11 probable transmembrane helices predicted for SBG3327 by TMHMM2.0 at aa 43-65, 90-112, 127-149,156-178, 193-212, 219-241, 261-283, 346-368, 378-400,407-429 and 439-458 218493018196 AsmA family; Region: AsmA; pfam05170 218493018197 signal peptide predicted for SBG3328 by SignalP 2.0 HMM (Signal peptide probabilty 0.893) with cleavage site probability 0.838 between residues 31 and 32 218493018199 1 probable transmembrane helix predicted for SBG3328 by TMHMM2.0 at aa 7-26 218493018200 putative alpha-glucosidase; Provisional; Region: PRK10658 218493018201 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 218493018202 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 218493018203 active site 218493018204 homotrimer interface [polypeptide binding]; other site 218493018205 catalytic site [active] 218493018206 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 218493018208 putative transporter; Provisional; Region: PRK11462 218493018209 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218493018210 11 probable transmembrane helices predicted for SBG3330 by TMHMM2.0 at aa 32-54, 81-100, 115-137,150-170, 180-202, 232-254, 264-286, 293-315, 320-342,363-385 and 400-422 218493018212 constitutes part of SPI-3 218493018213 Isochorismatase family; Region: Isochorismatase; pfam00857 218493018214 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 218493018215 catalytic triad [active] 218493018216 dimer interface [polypeptide binding]; other site 218493018217 conserved cis-peptide bond; other site 218493018219 signal peptide predicted for SBG3333 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.953 between residues 26 and 27 218493018220 2 probable transmembrane helices predicted for SBG3333 by TMHMM2.0 at aa 7-26 and 135-157 218493018221 magnesium-transporting ATPase; Provisional; Region: PRK15122 218493018222 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 218493018223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493018224 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 218493018225 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 218493018226 Soluble P-type ATPase [General function prediction only]; Region: COG4087 218493018227 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 218493018228 8 probable transmembrane helices predicted for SBG3334 by TMHMM2.0 at aa 87-105, 115-134, 293-315,325-347, 719-741, 779-801, 837-859 and 874-893 218493018233 magnesium transport protein MgtC; Provisional; Region: PRK15385 218493018234 MgtC family; Region: MgtC; pfam02308 218493018236 4 probable transmembrane helices predicted for SBG3335 by TMHMM2.0 at aa 5-27, 34-56, 66-83 and 90-112 218493018237 signal peptide predicted for SBG3336 by SignalP 2.0 HMM (Signal peptide probabilty 0.867) with cleavage site probability 0.702 between residues 25 and 26 218493018238 EamA-like transporter family; Region: EamA; pfam00892 218493018239 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218493018240 EamA-like transporter family; Region: EamA; pfam00892 218493018241 10 probable transmembrane helices predicted for SBG3336 by TMHMM2.0 at aa 7-29, 39-59, 72-94, 98-120,127-144, 154-176, 183-205, 215-237, 250-272 and 276-293 218493018244 there appears to have been an insertion into this CDS 218493018246 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 218493018249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218493018250 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 218493018253 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 218493018255 5 probable transmembrane helices predicted for SBG3341 by TMHMM2.0 at aa 128-147, 151-173, 197-216,236-258 and 265-284 218493018256 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 218493018258 5 probable transmembrane helices predicted for SBG3342 by TMHMM2.0 at aa 21-43, 93-110, 141-163, 183-203 and 210-232 218493018259 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218493018260 active site 218493018261 phosphorylation site [posttranslational modification] 218493018263 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493018264 active pocket/dimerization site; other site 218493018265 active site 218493018266 phosphorylation site [posttranslational modification] 218493018268 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 218493018269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493018270 Walker A motif; other site 218493018271 ATP binding site [chemical binding]; other site 218493018272 Walker B motif; other site 218493018273 arginine finger; other site 218493018274 Transcriptional antiterminator [Transcription]; Region: COG3933 218493018275 PRD domain; Region: PRD; pfam00874 218493018280 signal peptide predicted for SBG3346 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 21 and 22 218493018281 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 218493018282 beta-galactosidase; Region: BGL; TIGR03356 218493018285 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 218493018286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018287 putative substrate translocation pore; other site 218493018288 12 probable transmembrane helices predicted for SBG3348 by TMHMM2.0 at aa 20-42, 57-79, 86-105,110-132, 145-167, 177-196, 217-239, 254-276, 283-302,307-329, 341-363 and 367-389 218493018291 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 218493018293 1 probable transmembrane helix predicted for SBG3349 by TMHMM2.0 at aa 5-27 218493018297 PAAR motif; Region: PAAR_motif; cl15808 218493018298 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 218493018299 RHS Repeat; Region: RHS_repeat; pfam05593 218493018300 RHS Repeat; Region: RHS_repeat; pfam05593 218493018301 1 probable transmembrane helix predicted for SBG3355 by TMHMM2.0 at aa 949-971 218493018313 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 218493018314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018315 putative substrate translocation pore; other site 218493018316 12 probable transmembrane helices predicted for SBG3356 by TMHMM2.0 at aa 28-45, 67-89, 96-118,123-145, 158-180, 190-212, 254-276, 296-318, 325-347,357-379, 392-411 and 426-445 218493018320 regulatory protein UhpC; Provisional; Region: PRK11663 218493018321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018322 putative substrate translocation pore; other site 218493018323 12 probable transmembrane helices predicted for SBG3357 by TMHMM2.0 at aa 26-45, 67-89, 96-118,122-144, 156-178, 183-205, 245-267, 287-309, 322-344,348-370, 377-399 and 409-431 218493018326 signal peptide predicted for SBG3358 by SignalP 2.0 HMM (Signal peptide probabilty 0.915) with cleavage site probability 0.541 between residues 32 and 33 218493018327 sensory histidine kinase UhpB; Provisional; Region: PRK11644 218493018328 MASE1; Region: MASE1; pfam05231 218493018329 Histidine kinase; Region: HisKA_3; pfam07730 218493018330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493018331 ATP binding site [chemical binding]; other site 218493018332 Mg2+ binding site [ion binding]; other site 218493018333 G-X-G motif; other site 218493018338 7 probable transmembrane helices predicted for SBG3358 by TMHMM2.0 at aa 7-29, 78-100, 112-130, 140-162,183-205, 220-242 and 255-274 218493018339 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 218493018340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493018341 active site 218493018342 phosphorylation site [posttranslational modification] 218493018343 intermolecular recognition site; other site 218493018344 dimerization interface [polypeptide binding]; other site 218493018345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493018346 DNA binding residues [nucleotide binding] 218493018347 dimerization interface [polypeptide binding]; other site 218493018352 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 218493018353 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218493018354 putative valine binding site [chemical binding]; other site 218493018355 dimer interface [polypeptide binding]; other site 218493018357 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 218493018358 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218493018359 PYR/PP interface [polypeptide binding]; other site 218493018360 dimer interface [polypeptide binding]; other site 218493018361 TPP binding site [chemical binding]; other site 218493018362 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218493018363 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218493018364 TPP-binding site [chemical binding]; other site 218493018365 dimer interface [polypeptide binding]; other site 218493018371 signal peptide predicted for SBG3362 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.571 between residues 17 and 18 218493018372 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 218493018373 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 218493018374 10 probable transmembrane helices predicted for SBG3362 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-108,112-134, 141-158, 168-190, 207-226, 230-252 and 257-276 218493018378 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 218493018379 signal peptide predicted for SBG3363 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.954 between residues 23 and 24 218493018380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018381 putative substrate translocation pore; other site 218493018382 12 probable transmembrane helices predicted for SBG3363 by TMHMM2.0 at aa 7-29, 44-66, 75-94, 98-120,133-155, 165-182, 203-225, 240-262, 275-297, 301-323,330-352 and 362-384 218493018387 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 218493018388 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 218493018389 Domain of unknown function (DUF202); Region: DUF202; pfam02656 218493018390 3 probable transmembrane helices predicted for SBG3366 by TMHMM2.0 at aa 21-38, 48-70 and 91-113 218493018391 3 probable transmembrane helices predicted for SBG3367 by TMHMM2.0 at aa 12-31, 81-98 and 118-140 218493018393 putative transporter; Validated; Region: PRK03818 218493018394 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 218493018395 TrkA-C domain; Region: TrkA_C; pfam02080 218493018396 TrkA-C domain; Region: TrkA_C; pfam02080 218493018397 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 218493018398 10 probable transmembrane helices predicted for SBG3368 by TMHMM2.0 at aa 4-21, 28-47, 67-86, 93-115,160-182, 374-396, 400-419, 431-448, 463-485 and 530-552 218493018403 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 218493018404 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 218493018405 putative dimer interface [polypeptide binding]; other site 218493018407 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 218493018408 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 218493018409 putative dimer interface [polypeptide binding]; other site 218493018411 hypothetical protein; Provisional; Region: PRK11616 218493018414 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 218493018416 putative oxidoreductase; Provisional; Region: PRK11445 218493018417 hypothetical protein; Provisional; Region: PRK07236 218493018420 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 218493018421 signal peptide predicted for SBG3374 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 18 and 19 218493018422 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 218493018423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218493018424 binding surface 218493018425 TPR motif; other site 218493018427 2 probable transmembrane helices predicted for SBG3374 by TMHMM2.0 at aa 3-25 and 99-121 218493018428 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 218493018429 signal peptide predicted for SBG3375 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.445 between residues 28 and 29 218493018430 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 218493018431 catalytic residues [active] 218493018432 central insert; other site 218493018435 1 probable transmembrane helix predicted for SBG3375 by TMHMM2.0 at aa 5-24 218493018436 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 218493018437 15 probable transmembrane helices predicted for SBG3376 by TMHMM2.0 at aa 10-29, 41-63, 95-114,121-143, 176-198, 211-233, 248-265, 277-299, 314-332,353-375, 390-412, 425-444, 448-470, 482-504 and 610-629 218493018440 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 218493018442 1 probable transmembrane helix predicted for SBG3377 by TMHMM2.0 at aa 72-94 218493018443 heme exporter protein CcmC; Region: ccmC; TIGR01191 218493018444 6 probable transmembrane helices predicted for SBG3378 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 124-146,158-180 and 204-226 218493018446 heme exporter protein CcmB; Region: ccmB; TIGR01190 218493018448 6 probable transmembrane helices predicted for SBG3379 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150,157-179 and 194-216 218493018449 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 218493018450 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 218493018451 Walker A/P-loop; other site 218493018452 ATP binding site [chemical binding]; other site 218493018453 Q-loop/lid; other site 218493018454 ABC transporter signature motif; other site 218493018455 Walker B; other site 218493018456 D-loop; other site 218493018457 H-loop/switch region; other site 218493018461 Haem-binding domain; Region: Haem_bd; pfam14376 218493018462 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 218493018467 1 probable transmembrane helix predicted for SBG3381 by TMHMM2.0 at aa 7-29 218493018468 chaperone protein TorD; Validated; Region: torD; PRK04976 218493018470 signal peptide predicted for SBG3383 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 39 and 40 218493018471 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 218493018472 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 218493018473 molybdopterin cofactor binding site [chemical binding]; other site 218493018474 substrate binding site [chemical binding]; other site 218493018475 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 218493018476 molybdopterin cofactor binding site; other site 218493018481 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 218493018482 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 218493018483 signal peptide predicted for SBG3384 by SignalP 2.0 HMM (Signal peptide probabilty 0.671) with cleavage site probability 0.290 between residues 30 and 31 218493018489 1 probable transmembrane helix predicted for SBG3384 by TMHMM2.0 at aa 12-34 218493018490 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 218493018491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493018492 active site 218493018493 phosphorylation site [posttranslational modification] 218493018494 intermolecular recognition site; other site 218493018495 dimerization interface [polypeptide binding]; other site 218493018496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493018497 DNA binding site [nucleotide binding] 218493018501 signal peptide predicted for SBG3386 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.690 between residues 22 and 23 218493018502 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 218493018503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 218493018506 1 probable transmembrane helix predicted for SBG3386 by TMHMM2.0 at aa 7-29 218493018507 signal peptide predicted for SBG3387 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.578 between residues 24 and 25 218493018508 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 218493018509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493018510 dimer interface [polypeptide binding]; other site 218493018511 phosphorylation site [posttranslational modification] 218493018512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493018513 ATP binding site [chemical binding]; other site 218493018514 Mg2+ binding site [ion binding]; other site 218493018515 G-X-G motif; other site 218493018516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493018517 active site 218493018518 phosphorylation site [posttranslational modification] 218493018519 intermolecular recognition site; other site 218493018520 dimerization interface [polypeptide binding]; other site 218493018521 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218493018522 putative binding surface; other site 218493018523 active site 218493018524 2 probable transmembrane helices predicted for SBG3387 by TMHMM2.0 at aa 10-32 and 332-354 218493018531 signal peptide predicted for SBG3388 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.956 between residues 21 and 22 218493018532 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 218493018533 signal peptide predicted for SBG3389 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493018534 Surface antigen; Region: Bac_surface_Ag; pfam01103 218493018535 signal peptide predicted for SBG3390 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493018536 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 218493018537 sugar phosphate phosphatase; Provisional; Region: PRK10513 218493018538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493018539 active site 218493018540 motif I; other site 218493018541 motif II; other site 218493018542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493018546 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 218493018547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493018548 Mg2+ binding site [ion binding]; other site 218493018549 G-X-G motif; other site 218493018550 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218493018551 anchoring element; other site 218493018552 dimer interface [polypeptide binding]; other site 218493018553 ATP binding site [chemical binding]; other site 218493018554 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218493018555 active site 218493018556 putative metal-binding site [ion binding]; other site 218493018557 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218493018563 recF protein; Region: recf; TIGR00611 218493018564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493018565 Walker A/P-loop; other site 218493018566 ATP binding site [chemical binding]; other site 218493018567 Q-loop/lid; other site 218493018568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493018569 ABC transporter signature motif; other site 218493018570 Walker B; other site 218493018571 D-loop; other site 218493018572 H-loop/switch region; other site 218493018577 DNA polymerase III subunit beta; Validated; Region: PRK05643 218493018578 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 218493018579 putative DNA binding surface [nucleotide binding]; other site 218493018580 dimer interface [polypeptide binding]; other site 218493018581 beta-clamp/clamp loader binding surface; other site 218493018582 beta-clamp/translesion DNA polymerase binding surface; other site 218493018586 DnaA N-terminal domain; Region: DnaA_N; pfam11638 218493018587 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 218493018588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493018589 Walker A motif; other site 218493018590 ATP binding site [chemical binding]; other site 218493018591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 218493018592 Walker B motif; other site 218493018593 arginine finger; other site 218493018594 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218493018595 DnaA box-binding interface [nucleotide binding]; other site 218493018600 ribonuclease P; Reviewed; Region: rnpA; PRK01732 218493018603 membrane protein insertase; Provisional; Region: PRK01318 218493018604 signal peptide predicted for SBG3397 by SignalP 2.0 HMM (Signal peptide probabilty 0.911) with cleavage site probability 0.455 between residues 21 and 22 218493018605 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 218493018606 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 218493018607 5 probable transmembrane helices predicted for SBG3397 by TMHMM2.0 at aa 7-24, 346-368, 418-440, 460-477 and 497-519 218493018609 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 218493018610 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 218493018611 trmE is a tRNA modification GTPase; Region: trmE; cd04164 218493018612 G1 box; other site 218493018613 GTP/Mg2+ binding site [chemical binding]; other site 218493018614 Switch I region; other site 218493018615 G2 box; other site 218493018616 Switch II region; other site 218493018617 G3 box; other site 218493018618 G4 box; other site 218493018619 G5 box; other site 218493018620 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 218493018623 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 218493018624 signal peptide predicted for SBG3399 by SignalP 2.0 HMM (Signal peptide probabilty 0.934) with cleavage site probability 0.897 between residues 30 and 31 218493018625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018626 putative substrate translocation pore; other site 218493018627 11 probable transmembrane helices predicted for SBG3399 by TMHMM2.0 at aa 2-24, 39-61, 68-90, 94-116,129-151, 156-178, 203-222, 242-264, 277-309, 324-346 and 353-375 218493018630 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 218493018631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493018632 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 218493018633 substrate binding pocket [chemical binding]; other site 218493018634 dimerization interface [polypeptide binding]; other site 218493018637 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 218493018638 Predicted flavoprotein [General function prediction only]; Region: COG0431 218493018639 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218493018641 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 218493018642 13 probable transmembrane helices predicted for SBG3403 by TMHMM2.0 at aa 61-83, 93-115, 117-139,144-166, 173-192, 207-229, 236-253, 284-306, 326-348,358-380, 387-405, 420-442 and 455-473 218493018645 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 218493018646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 218493018647 active site 218493018648 motif I; other site 218493018649 motif II; other site 218493018651 transcriptional regulator PhoU; Provisional; Region: PRK11115 218493018652 PhoU domain; Region: PhoU; pfam01895 218493018653 PhoU domain; Region: PhoU; pfam01895 218493018656 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 218493018657 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 218493018658 Walker A/P-loop; other site 218493018659 ATP binding site [chemical binding]; other site 218493018660 Q-loop/lid; other site 218493018661 ABC transporter signature motif; other site 218493018662 Walker B; other site 218493018663 D-loop; other site 218493018664 H-loop/switch region; other site 218493018668 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 218493018669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493018670 dimer interface [polypeptide binding]; other site 218493018671 conserved gate region; other site 218493018672 putative PBP binding loops; other site 218493018673 ABC-ATPase subunit interface; other site 218493018675 6 probable transmembrane helices predicted for SBG3407 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169,201-223 and 268-290 218493018677 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 218493018678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493018679 dimer interface [polypeptide binding]; other site 218493018680 conserved gate region; other site 218493018681 putative PBP binding loops; other site 218493018682 ABC-ATPase subunit interface; other site 218493018684 6 probable transmembrane helices predicted for SBG3408 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188,227-249 and 282-304 218493018686 signal peptide predicted for SBG3409 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.537 between residues 25 and 26 218493018687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493018689 1 probable transmembrane helix predicted for SBG3409 by TMHMM2.0 at aa 7-29 218493018690 sbd fimbrial operon 218493018691 signal peptide predicted for SBG3410 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 20 and 21 218493018692 Fimbrial protein; Region: Fimbrial; cl01416 218493018695 signal peptide predicted for SBG3411 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25 218493018696 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 218493018697 PapC N-terminal domain; Region: PapC_N; pfam13954 218493018698 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493018699 PapC C-terminal domain; Region: PapC_C; pfam13953 218493018701 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 218493018702 signal peptide predicted for SBG3412 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.978 between residues 27 and 28 218493018703 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493018704 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493018708 1 probable transmembrane helix predicted for SBG3412 by TMHMM2.0 at aa 12-34 218493018709 Fimbrial protein; Region: Fimbrial; cl01416 218493018710 signal peptide predicted for SBG3413 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24 218493018712 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 218493018713 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 218493018714 glutaminase active site [active] 218493018715 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218493018716 dimer interface [polypeptide binding]; other site 218493018717 active site 218493018718 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218493018719 dimer interface [polypeptide binding]; other site 218493018720 active site 218493018725 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 218493018726 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 218493018727 Substrate binding site; other site 218493018728 Mg++ binding site; other site 218493018729 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 218493018730 active site 218493018731 substrate binding site [chemical binding]; other site 218493018732 CoA binding site [chemical binding]; other site 218493018741 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 218493018742 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 218493018743 gamma subunit interface [polypeptide binding]; other site 218493018744 epsilon subunit interface [polypeptide binding]; other site 218493018745 LBP interface [polypeptide binding]; other site 218493018748 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 218493018749 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218493018750 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 218493018751 alpha subunit interaction interface [polypeptide binding]; other site 218493018752 Walker A motif; other site 218493018753 ATP binding site [chemical binding]; other site 218493018754 Walker B motif; other site 218493018755 inhibitor binding site; inhibition site 218493018756 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218493018762 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 218493018763 core domain interface [polypeptide binding]; other site 218493018764 delta subunit interface [polypeptide binding]; other site 218493018765 epsilon subunit interface [polypeptide binding]; other site 218493018768 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 218493018769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218493018770 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 218493018771 beta subunit interaction interface [polypeptide binding]; other site 218493018772 Walker A motif; other site 218493018773 ATP binding site [chemical binding]; other site 218493018774 Walker B motif; other site 218493018775 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218493018781 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 218493018782 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 218493018785 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 218493018786 signal peptide predicted for SBG3421 by SignalP 2.0 HMM (Signal peptide probabilty 0.740) with cleavage site probability 0.704 between residues 31 and 32 218493018787 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 218493018789 1 probable transmembrane helix predicted for SBG3421 by TMHMM2.0 at aa 5-27 218493018790 signal peptide predicted for SBG3422 by SignalP 2.0 HMM (Signal peptide probabilty 0.749) with cleavage site probability 0.528 between residues 23 and 24 218493018791 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 218493018793 2 probable transmembrane helices predicted for SBG3422 by TMHMM2.0 at aa 10-32 and 53-75 218493018795 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 218493018796 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 218493018798 5 probable transmembrane helices predicted for SBG3423 by TMHMM2.0 at aa 36-58, 100-122, 142-164, 211-233 and 243-265 218493018800 signal peptide predicted for SBG3424 by SignalP 2.0 HMM (Signal peptide probabilty 0.812) with cleavage site probability 0.551 between residues 49 and 50 218493018801 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 218493018803 4 probable transmembrane helices predicted for SBG3424 by TMHMM2.0 at aa 15-32, 37-59, 74-96 and 101-123 218493018804 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 218493018805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493018806 S-adenosylmethionine binding site [chemical binding]; other site 218493018808 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 218493018809 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 218493018810 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 218493018814 FMN-binding protein MioC; Provisional; Region: PRK09004 218493018816 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 218493018817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493018818 putative DNA binding site [nucleotide binding]; other site 218493018819 putative Zn2+ binding site [ion binding]; other site 218493018820 AsnC family; Region: AsnC_trans_reg; pfam01037 218493018823 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 218493018824 dimer interface [polypeptide binding]; other site 218493018825 active site 218493018827 hypothetical protein; Provisional; Region: yieM; PRK10997 218493018828 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 218493018829 metal ion-dependent adhesion site (MIDAS); other site 218493018830 regulatory ATPase RavA; Provisional; Region: PRK13531 218493018831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493018832 Walker A motif; other site 218493018833 ATP binding site [chemical binding]; other site 218493018834 Walker B motif; other site 218493018835 arginine finger; other site 218493018836 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 218493018838 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 218493018839 signal peptide predicted for SBG3433 by SignalP 2.0 HMM (Signal peptide probabilty 0.785) with cleavage site probability 0.784 between residues 22 and 23 218493018840 potassium uptake protein; Region: kup; TIGR00794 218493018841 12 probable transmembrane helices predicted for SBG3433 by TMHMM2.0 at aa 7-29, 49-71, 102-124,134-156, 168-190, 210-232, 245-267, 287-309, 335-357,363-385, 392-414 and 419-441 218493018843 D-ribose pyranase; Provisional; Region: PRK11797 218493018845 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 218493018846 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218493018847 Walker A/P-loop; other site 218493018848 ATP binding site [chemical binding]; other site 218493018849 Q-loop/lid; other site 218493018850 ABC transporter signature motif; other site 218493018851 Walker B; other site 218493018852 D-loop; other site 218493018853 H-loop/switch region; other site 218493018854 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218493018859 signal peptide predicted for SBG3436 by SignalP 2.0 HMM (Signal peptide probabilty 0.682) with cleavage site probability 0.480 between residues 42 and 43 218493018860 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218493018861 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218493018862 TM-ABC transporter signature motif; other site 218493018863 8 probable transmembrane helices predicted for SBG3436 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 98-120,127-149, 169-191, 221-243 and 275-297 218493018865 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 218493018866 signal peptide predicted for SBG3437 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.950 between residues 25 and 26 218493018867 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 218493018868 ligand binding site [chemical binding]; other site 218493018869 dimerization interface [polypeptide binding]; other site 218493018871 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493018872 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 218493018873 substrate binding site [chemical binding]; other site 218493018874 dimer interface [polypeptide binding]; other site 218493018875 ATP binding site [chemical binding]; other site 218493018879 transcriptional repressor RbsR; Provisional; Region: PRK10423 218493018880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493018881 DNA binding site [nucleotide binding] 218493018882 domain linker motif; other site 218493018883 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 218493018884 dimerization interface [polypeptide binding]; other site 218493018885 ligand binding site [chemical binding]; other site 218493018889 signal peptide predicted for SBG3440 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.790 between residues 38 and 39 218493018890 putative transporter; Provisional; Region: PRK10504 218493018891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018892 putative substrate translocation pore; other site 218493018893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493018894 14 probable transmembrane helices predicted for SBG3440 by TMHMM2.0 at aa 11-33, 48-70, 77-99,103-125, 137-159, 164-183, 196-218, 222-244, 264-286,291-313, 325-347, 351-373, 394-416 and 431-450 218493018898 Transcriptional regulators [Transcription]; Region: FadR; COG2186 218493018899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493018900 DNA-binding site [nucleotide binding]; DNA binding site 218493018901 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493018905 transcriptional regulator HdfR; Provisional; Region: PRK03601 218493018906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493018907 LysR substrate binding domain; Region: LysR_substrate; pfam03466 218493018908 dimerization interface [polypeptide binding]; other site 218493018912 hypothetical protein; Provisional; Region: PRK11027 218493018914 putative ATP-dependent protease; Provisional; Region: PRK09862 218493018915 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 218493018916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493018917 Walker A motif; other site 218493018918 ATP binding site [chemical binding]; other site 218493018919 Walker B motif; other site 218493018920 arginine finger; other site 218493018921 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 218493018925 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 218493018926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218493018927 PYR/PP interface [polypeptide binding]; other site 218493018928 dimer interface [polypeptide binding]; other site 218493018929 TPP binding site [chemical binding]; other site 218493018930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218493018931 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218493018932 TPP-binding site [chemical binding]; other site 218493018933 dimer interface [polypeptide binding]; other site 218493018939 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 218493018940 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218493018941 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 218493018942 homodimer interface [polypeptide binding]; other site 218493018943 substrate-cofactor binding pocket; other site 218493018944 catalytic residue [active] 218493018947 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 218493018952 threonine dehydratase; Reviewed; Region: PRK09224 218493018953 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218493018954 tetramer interface [polypeptide binding]; other site 218493018955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493018956 catalytic residue [active] 218493018957 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 218493018958 putative Ile/Val binding site [chemical binding]; other site 218493018959 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 218493018960 putative Ile/Val binding site [chemical binding]; other site 218493018965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493018966 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 218493018967 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 218493018968 putative dimerization interface [polypeptide binding]; other site 218493018972 ketol-acid reductoisomerase; Validated; Region: PRK05225 218493018973 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 218493018974 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218493018975 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218493018978 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 218493018979 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 218493018982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218493018983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218493018984 ligand binding site [chemical binding]; other site 218493018985 flexible hinge region; other site 218493018986 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 218493018987 uridine phosphorylase; Provisional; Region: PRK11178 218493018988 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218493018991 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 218493018993 7 probable transmembrane helices predicted for SBG3455 by TMHMM2.0 at aa 20-39, 46-63, 67-89, 110-132,159-178, 185-204 and 209-226 218493018994 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 218493018995 Part of AAA domain; Region: AAA_19; pfam13245 218493018996 Family description; Region: UvrD_C_2; pfam13538 218493018999 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 218493019000 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 218493019003 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 218493019004 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218493019005 ATP binding site [chemical binding]; other site 218493019006 Mg++ binding site [ion binding]; other site 218493019007 motif III; other site 218493019008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493019009 nucleotide binding region [chemical binding]; other site 218493019010 ATP-binding site [chemical binding]; other site 218493019016 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218493019017 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218493019018 catalytic residues [active] 218493019021 transcription termination factor Rho; Provisional; Region: rho; PRK09376 218493019022 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 218493019023 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 218493019024 RNA binding site [nucleotide binding]; other site 218493019025 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 218493019026 multimer interface [polypeptide binding]; other site 218493019027 Walker A motif; other site 218493019028 ATP binding site [chemical binding]; other site 218493019029 Walker B motif; other site 218493019035 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 218493019036 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 218493019037 Mg++ binding site [ion binding]; other site 218493019038 putative catalytic motif [active] 218493019039 substrate binding site [chemical binding]; other site 218493019040 11 probable transmembrane helices predicted for SBG3461 by TMHMM2.0 at aa 5-24, 45-66, 70-89, 105-127,131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338 218493019042 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 218493019043 Chain length determinant protein; Region: Wzz; pfam02706 218493019045 2 probable transmembrane helices predicted for SBG3462 by TMHMM2.0 at aa 29-51 and 323-342 218493019046 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 218493019047 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 218493019048 active site 218493019049 homodimer interface [polypeptide binding]; other site 218493019051 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 218493019052 signal peptide predicted for SBG3464 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.891 between residues 23 and 24 218493019053 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 218493019054 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 218493019055 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 218493019060 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 218493019061 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 218493019062 NAD binding site [chemical binding]; other site 218493019063 substrate binding site [chemical binding]; other site 218493019064 homodimer interface [polypeptide binding]; other site 218493019065 active site 218493019067 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 218493019068 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 218493019069 substrate binding site; other site 218493019070 tetramer interface; other site 218493019072 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 218493019074 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 218493019075 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218493019076 inhibitor-cofactor binding pocket; inhibition site 218493019077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493019078 catalytic residue [active] 218493019081 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 218493019082 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 218493019084 12 probable transmembrane helices predicted for SBG3469 by TMHMM2.0 at aa 13-35, 45-67, 80-102,117-139, 146-165, 175-195, 216-238, 253-275, 296-318,333-355, 362-384 and 390-412 218493019085 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 218493019087 putative common antigen polymerase; Provisional; Region: PRK02975 218493019088 signal peptide predicted for SBG3471 by SignalP 2.0 HMM (Signal peptide probabilty 0.715) with cleavage site probability 0.418 between residues 21 and 22 218493019090 11 probable transmembrane helices predicted for SBG3471 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138,153-175, 182-201, 205-224, 226-245, 338-360, 381-398 and 408-430 218493019093 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 218493019094 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 218493019096 putative transport protein YifK; Provisional; Region: PRK10746 218493019098 12 probable transmembrane helices predicted for SBG3473 by TMHMM2.0 at aa 19-36, 40-59, 93-115,125-147, 154-176, 191-213, 240-262, 277-299, 331-353,358-380, 401-423 and 428-450 218493019103 signal peptide predicted for SBG3474 by SignalP 2.0 HMM (Signal peptide probabilty 0.954) with cleavage site probability 0.424 between residues 19 and 20 218493019104 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 218493019105 HemY protein N-terminus; Region: HemY_N; pfam07219 218493019109 2 probable transmembrane helices predicted for SBG3474 by TMHMM2.0 at aa 5-27 and 42-64 218493019110 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 218493019111 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 218493019113 1 probable transmembrane helix predicted for SBG3475 by TMHMM2.0 at aa 35-57 218493019114 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 218493019115 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 218493019116 active site 218493019118 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 218493019119 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 218493019120 domain interfaces; other site 218493019121 active site 218493019125 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 218493019126 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 218493019127 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 218493019133 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 218493019134 putative iron binding site [ion binding]; other site 218493019136 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 218493019137 signal peptide predicted for SBG3480 by SignalP 2.0 HMM (Signal peptide probabilty 0.926) with cleavage site probability 0.396 between residues 23 and 24 218493019138 1 probable transmembrane helix predicted for SBG3480 by TMHMM2.0 at aa 7-29 218493019140 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 218493019141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218493019142 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218493019146 hypothetical protein; Provisional; Region: PRK10963 218493019148 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 218493019149 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 218493019150 active site 218493019151 Int/Topo IB signature motif; other site 218493019154 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 218493019155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493019156 motif II; other site 218493019158 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 218493019159 Part of AAA domain; Region: AAA_19; pfam13245 218493019160 Family description; Region: UvrD_C_2; pfam13538 218493019163 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 218493019164 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 218493019165 Cl binding site [ion binding]; other site 218493019166 oligomer interface [polypeptide binding]; other site 218493019168 2 probable transmembrane helices predicted for SBG3486 by TMHMM2.0 at aa 255-273 and 288-310 218493019169 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 218493019170 signal peptide predicted for SBG3487 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.341 between residues 20 and 21 218493019172 1 probable transmembrane helix predicted for SBG3487 by TMHMM2.0 at aa 7-24 218493019173 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 218493019174 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 218493019175 10 probable transmembrane helices predicted for SBG3489 by TMHMM2.0 at aa 12-34, 38-60, 73-95,100-122, 129-146, 150-167, 180-197, 212-234, 239-261 and 271-290 218493019178 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218493019179 CoenzymeA binding site [chemical binding]; other site 218493019180 subunit interaction site [polypeptide binding]; other site 218493019181 PHB binding site; other site 218493019183 signal peptide predicted for SBG3491 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.980 between residues 20 and 21 218493019184 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 218493019185 dimerization interface [polypeptide binding]; other site 218493019186 substrate binding site [chemical binding]; other site 218493019187 active site 218493019188 calcium binding site [ion binding]; other site 218493019190 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 218493019191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493019192 ATP binding site [chemical binding]; other site 218493019193 putative Mg++ binding site [ion binding]; other site 218493019194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218493019195 nucleotide binding region [chemical binding]; other site 218493019196 ATP-binding site [chemical binding]; other site 218493019197 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 218493019198 Helicase and RNase D C-terminal; Region: HRDC; smart00341 218493019204 threonine efflux system; Provisional; Region: PRK10229 218493019205 6 probable transmembrane helices predicted for SBG3493 by TMHMM2.0 at aa 4-26, 42-64, 68-87, 119-141,151-173 and 186-205 218493019207 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 218493019208 signal peptide predicted for SBG3494 by SignalP 2.0 HMM (Signal peptide probabilty 0.892) with cleavage site probability 0.438 between residues 24 and 25 218493019209 5 probable transmembrane helices predicted for SBG3494 by TMHMM2.0 at aa 7-29, 49-71, 115-137, 147-169 and 188-205 218493019211 lysophospholipase L2; Provisional; Region: PRK10749 218493019212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218493019214 putative hydrolase; Provisional; Region: PRK10976 218493019215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493019216 active site 218493019217 motif I; other site 218493019218 motif II; other site 218493019219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493019223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218493019224 EamA-like transporter family; Region: EamA; pfam00892 218493019225 10 probable transmembrane helices predicted for SBG3497 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102,109-128, 138-157, 170-192, 202-224, 231-253 and 258-275 218493019227 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 218493019228 signal peptide predicted for SBG3498 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.599 between residues 34 and 35 218493019229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493019230 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 218493019231 putative dimerization interface [polypeptide binding]; other site 218493019235 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 218493019236 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 218493019237 THF binding site; other site 218493019238 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218493019239 substrate binding site [chemical binding]; other site 218493019240 THF binding site; other site 218493019241 zinc-binding site [ion binding]; other site 218493019244 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 218493019245 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 218493019247 uridine phosphorylase; Provisional; Region: PRK11178 218493019248 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 218493019251 DNA recombination protein RmuC; Provisional; Region: PRK10361 218493019252 signal peptide predicted for SBG3502 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.988 between residues 28 and 29 218493019253 RmuC family; Region: RmuC; pfam02646 218493019254 1 probable transmembrane helix predicted for SBG3502 by TMHMM2.0 at aa 5-24 218493019256 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 218493019257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493019258 S-adenosylmethionine binding site [chemical binding]; other site 218493019262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 218493019263 SCP-2 sterol transfer family; Region: SCP2; pfam02036 218493019265 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 218493019266 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 218493019268 1 probable transmembrane helix predicted for SBG3505 by TMHMM2.0 at aa 523-542 218493019269 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 218493019271 1 probable transmembrane helix predicted for SBG3506 by TMHMM2.0 at aa 4-21 218493019272 sec-independent translocase; Provisional; Region: PRK01770 218493019273 sec-independent translocase; Provisional; Region: tatB; PRK00404 218493019275 1 probable transmembrane helix predicted for SBG3507 by TMHMM2.0 at aa 4-21 218493019276 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 218493019278 6 probable transmembrane helices predicted for SBG3508 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180,193-210 and 215-237 218493019280 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218493019281 active site 218493019285 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 218493019286 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 218493019287 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 218493019289 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 218493019291 FMN reductase; Validated; Region: fre; PRK08051 218493019292 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 218493019293 FAD binding pocket [chemical binding]; other site 218493019294 FAD binding motif [chemical binding]; other site 218493019295 phosphate binding motif [ion binding]; other site 218493019296 beta-alpha-beta structure motif; other site 218493019297 NAD binding pocket [chemical binding]; other site 218493019300 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 218493019301 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218493019302 dimer interface [polypeptide binding]; other site 218493019303 active site 218493019310 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 218493019311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218493019312 substrate binding site [chemical binding]; other site 218493019313 oxyanion hole (OAH) forming residues; other site 218493019314 trimer interface [polypeptide binding]; other site 218493019315 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 218493019316 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218493019317 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218493019325 proline dipeptidase; Provisional; Region: PRK13607 218493019326 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 218493019327 active site 218493019330 hypothetical protein; Provisional; Region: PRK11568 218493019331 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 218493019332 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 218493019336 potassium transporter; Provisional; Region: PRK10750 218493019337 signal peptide predicted for SBG3517 by SignalP 2.0 HMM (Signal peptide probabilty 0.817) with cleavage site probability 0.447 between residues 27 and 28 218493019338 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 218493019339 10 probable transmembrane helices predicted for SBG3517 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155,185-207, 238-260, 273-295, 332-354, 396-418 and 456-478 218493019344 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 218493019347 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 218493019348 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 218493019349 GTP binding site; other site 218493019350 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 218493019352 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 218493019353 serine/threonine protein kinase; Provisional; Region: PRK11768 218493019355 signal peptide predicted for SBG3522 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.933 between residues 19 and 20 218493019356 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 218493019357 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 218493019358 catalytic residues [active] 218493019359 hinge region; other site 218493019360 alpha helical domain; other site 218493019363 signal peptide predicted for SBG3523 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.400 between residues 25 and 26 218493019364 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218493019365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 218493019366 putative acyl-acceptor binding pocket; other site 218493019368 3 probable transmembrane helices predicted for SBG3523 by TMHMM2.0 at aa 12-34, 49-66 and 122-140 218493019370 DNA polymerase I; Provisional; Region: PRK05755 218493019371 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218493019372 active site 218493019373 metal binding site 1 [ion binding]; metal-binding site 218493019374 putative 5' ssDNA interaction site; other site 218493019375 metal binding site 3; metal-binding site 218493019376 metal binding site 2 [ion binding]; metal-binding site 218493019377 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218493019378 putative DNA binding site [nucleotide binding]; other site 218493019379 putative metal binding site [ion binding]; other site 218493019380 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 218493019381 active site 218493019382 catalytic site [active] 218493019383 substrate binding site [chemical binding]; other site 218493019384 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 218493019385 active site 218493019386 DNA binding site [nucleotide binding] 218493019387 catalytic site [active] 218493019393 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 218493019394 G1 box; other site 218493019395 GTP/Mg2+ binding site [chemical binding]; other site 218493019396 Switch I region; other site 218493019397 G2 box; other site 218493019398 G3 box; other site 218493019399 Switch II region; other site 218493019400 G4 box; other site 218493019401 G5 box; other site 218493019404 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 218493019405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 218493019407 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 218493019408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493019409 FeS/SAM binding site; other site 218493019410 HemN C-terminal domain; Region: HemN_C; pfam06969 218493019413 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 218493019414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493019415 active site 218493019416 phosphorylation site [posttranslational modification] 218493019417 intermolecular recognition site; other site 218493019418 dimerization interface [polypeptide binding]; other site 218493019419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493019420 Walker A motif; other site 218493019421 ATP binding site [chemical binding]; other site 218493019422 Walker B motif; other site 218493019423 arginine finger; other site 218493019424 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218493019431 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 218493019432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218493019433 putative active site [active] 218493019434 heme pocket [chemical binding]; other site 218493019435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493019436 dimer interface [polypeptide binding]; other site 218493019437 phosphorylation site [posttranslational modification] 218493019438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493019439 ATP binding site [chemical binding]; other site 218493019440 Mg2+ binding site [ion binding]; other site 218493019441 G-X-G motif; other site 218493019445 glutamine synthetase; Provisional; Region: glnA; PRK09469 218493019446 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 218493019447 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 218493019453 GTP-binding protein; Provisional; Region: PRK10218 218493019454 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 218493019455 G1 box; other site 218493019456 putative GEF interaction site [polypeptide binding]; other site 218493019457 GTP/Mg2+ binding site [chemical binding]; other site 218493019458 Switch I region; other site 218493019459 G2 box; other site 218493019460 G3 box; other site 218493019461 Switch II region; other site 218493019462 G4 box; other site 218493019463 G5 box; other site 218493019464 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 218493019465 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 218493019471 outer membrane porin L; Provisional; Region: ompL; PRK09980 218493019472 signal peptide predicted for SBG3533 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.903 between residues 20 and 21 218493019474 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 218493019475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493019476 putative substrate translocation pore; other site 218493019477 11 probable transmembrane helices predicted for SBG3534 by TMHMM2.0 at aa 20-42, 52-74, 86-108,118-140, 161-180, 185-207, 237-259, 274-296, 317-339,380-402 and 415-434 218493019481 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218493019482 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 218493019483 11 probable transmembrane helices predicted for SBG3535 by TMHMM2.0 at aa 46-68, 89-111, 121-143,156-178, 188-210, 244-266, 276-295, 308-328, 333-355,387-409 and 419-441 218493019488 alpha-glucosidase; Provisional; Region: PRK10426 218493019489 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 218493019490 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 218493019491 putative active site [active] 218493019492 putative catalytic site [active] 218493019494 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 218493019495 active site 218493019496 catalytic residues [active] 218493019499 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 218493019500 dimerization interface [polypeptide binding]; other site 218493019501 putative active cleft [active] 218493019503 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 218493019505 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 218493019506 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218493019509 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218493019510 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 218493019511 substrate binding site [chemical binding]; other site 218493019512 ATP binding site [chemical binding]; other site 218493019515 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218493019516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218493019517 putative DNA binding site [nucleotide binding]; other site 218493019518 putative Zn2+ binding site [ion binding]; other site 218493019519 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493019523 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 218493019524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493019525 motif II; other site 218493019527 hypothetical protein; Reviewed; Region: PRK01637 218493019529 6 probable transmembrane helices predicted for SBG3544 by TMHMM2.0 at aa 39-61, 101-120, 141-163,183-200, 212-234 and 244-266 218493019530 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 218493019531 putative active site [active] 218493019532 dimerization interface [polypeptide binding]; other site 218493019533 putative tRNAtyr binding site [nucleotide binding]; other site 218493019535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493019536 Coenzyme A binding pocket [chemical binding]; other site 218493019537 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 218493019539 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 218493019540 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 218493019542 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 218493019543 signal peptide predicted for SBG3548 by SignalP 2.0 HMM (Signal peptide probabilty 0.663) with cleavage site probability 0.484 between residues 53 and 54 218493019544 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 218493019546 4 probable transmembrane helices predicted for SBG3548 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173 218493019547 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 218493019548 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 218493019552 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 218493019553 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 218493019554 [4Fe-4S] binding site [ion binding]; other site 218493019555 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218493019556 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 218493019557 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 218493019558 molybdopterin cofactor binding site; other site 218493019563 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 218493019565 signal peptide predicted for SBG3552 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.476 between residues 21 and 22 218493019567 1 probable transmembrane helix predicted for SBG3552 by TMHMM2.0 at aa 7-29 218493019568 signal peptide predicted for SBG3553 by SignalP 2.0 HMM (Signal peptide probabilty 0.620) with cleavage site probability 0.201 between residues 16 and 17 218493019569 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 218493019570 4 probable transmembrane helices predicted for SBG3553 by TMHMM2.0 at aa 4-26, 38-60, 65-82 and 87-106 218493019572 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 218493019573 signal peptide predicted for SBG3554 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.909 between residues 36 and 37 218493019574 5 probable transmembrane helices predicted for SBG3554 by TMHMM2.0 at aa 16-38, 58-80, 127-149, 159-178 and 191-213 218493019576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493019577 non-specific DNA binding site [nucleotide binding]; other site 218493019578 salt bridge; other site 218493019579 sequence-specific DNA binding site [nucleotide binding]; other site 218493019580 Cupin domain; Region: Cupin_2; cl17218 218493019584 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 218493019586 lactaldehyde reductase; Region: lactal_redase; TIGR02638 218493019587 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 218493019588 dimer interface [polypeptide binding]; other site 218493019589 active site 218493019590 metal binding site [ion binding]; metal-binding site 218493019594 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 218493019595 intersubunit interface [polypeptide binding]; other site 218493019596 active site 218493019597 Zn2+ binding site [ion binding]; other site 218493019599 L-rhamnose isomerase; Provisional; Region: PRK01076 218493019600 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 218493019602 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 218493019603 N- and C-terminal domain interface [polypeptide binding]; other site 218493019604 active site 218493019605 putative catalytic site [active] 218493019606 metal binding site [ion binding]; metal-binding site 218493019607 ATP binding site [chemical binding]; other site 218493019608 rhamnulokinase; Provisional; Region: rhaB; PRK10640 218493019609 carbohydrate binding site [chemical binding]; other site 218493019613 transcriptional activator RhaS; Provisional; Region: PRK13503 218493019614 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218493019615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493019616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493019621 transcriptional activator RhaR; Provisional; Region: PRK13502 218493019622 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218493019623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493019627 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 218493019628 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 218493019630 10 probable transmembrane helices predicted for SBG3563 by TMHMM2.0 at aa 4-26, 38-57, 61-83, 96-118,133-155, 175-192, 212-234, 254-276, 291-310 and 321-343 218493019632 signal peptide predicted for SBG3564 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.987 between residues 22 and 23 218493019633 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 218493019635 signal peptide predicted for SBG3565 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.354 between residues 51 and 52 218493019636 DctM-like transporters; Region: DctM; pfam06808 218493019637 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 218493019638 11 probable transmembrane helices predicted for SBG3565 by TMHMM2.0 at aa 10-41, 61-83, 103-125,146-168, 178-200, 221-243, 248-267, 280-302, 322-356,368-390 and 405-427 218493019641 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 218493019642 signal peptide predicted for SBG3566 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.502 between residues 27 and 28 218493019644 4 probable transmembrane helices predicted for SBG3566 by TMHMM2.0 at aa 10-29, 50-66, 86-108 and 129-151 218493019646 signal peptide predicted for SBG3567 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.983 between residues 24 and 25 218493019647 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 218493019648 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 218493019650 superoxide dismutase; Provisional; Region: PRK10925 218493019651 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218493019652 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218493019656 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 218493019657 MOSC domain; Region: MOSC; pfam03473 218493019658 3-alpha domain; Region: 3-alpha; pfam03475 218493019661 two-component sensor protein; Provisional; Region: cpxA; PRK09470 218493019662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493019663 dimerization interface [polypeptide binding]; other site 218493019664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493019665 dimer interface [polypeptide binding]; other site 218493019666 phosphorylation site [posttranslational modification] 218493019667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493019668 ATP binding site [chemical binding]; other site 218493019669 Mg2+ binding site [ion binding]; other site 218493019670 G-X-G motif; other site 218493019674 2 probable transmembrane helices predicted for SBG3570 by TMHMM2.0 at aa 5-27 and 165-187 218493019675 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 218493019676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493019677 active site 218493019678 intermolecular recognition site; other site 218493019679 dimerization interface [polypeptide binding]; other site 218493019680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493019681 DNA binding site [nucleotide binding] 218493019684 signal peptide predicted for SBG3572 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218493019685 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218493019686 dimer interface [polypeptide binding]; other site 218493019689 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 218493019690 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 218493019691 signal peptide predicted for SBG3573 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.626 between residues 41 and 42 218493019692 6 probable transmembrane helices predicted for SBG3573 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139,158-175 and 180-199 218493019694 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 218493019695 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 218493019696 active site 218493019697 ADP/pyrophosphate binding site [chemical binding]; other site 218493019698 dimerization interface [polypeptide binding]; other site 218493019699 allosteric effector site; other site 218493019700 fructose-1,6-bisphosphate binding site; other site 218493019704 signal peptide predicted for SBG3575 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.956 between residues 19 and 20 218493019705 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218493019706 PBP superfamily domain; Region: PBP_like; cl17867 218493019707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218493019708 membrane-bound complex binding site; other site 218493019709 hinge residues; other site 218493019713 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 218493019714 signal peptide predicted for SBG3576 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.787 between residues 17 and 18 218493019716 1 probable transmembrane helix predicted for SBG3576 by TMHMM2.0 at aa 5-23 218493019717 signal peptide predicted for SBG3577 by SignalP 2.0 HMM (Signal peptide probabilty 0.884) with cleavage site probability 0.812 between residues 43 and 44 218493019718 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493019719 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 218493019720 transmembrane helices; other site 218493019721 11 probable transmembrane helices predicted for SBG3577 by TMHMM2.0 at aa 15-40, 52-74, 94-113,142-164, 195-214, 235-254, 258-275, 288-310, 330-352,364-386 and 406-428 218493019723 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 218493019724 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218493019725 transmembrane helices; other site 218493019727 11 probable transmembrane helices predicted for SBG3578 by TMHMM2.0 at aa 7-26, 41-63, 192-214,229-251, 275-297, 307-329, 342-364, 374-396, 409-431,436-458 and 465-487 218493019728 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218493019729 triosephosphate isomerase; Provisional; Region: PRK14567 218493019730 substrate binding site [chemical binding]; other site 218493019731 dimer interface [polypeptide binding]; other site 218493019732 catalytic triad [active] 218493019736 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 218493019737 signal peptide predicted for SBG3580 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.467 between residues 23 and 24 218493019739 Predicted membrane protein [Function unknown]; Region: COG3152 218493019740 signal peptide predicted for SBG3581 by SignalP 2.0 HMM (Signal peptide probabilty 0.786) with cleavage site probability 0.716 between residues 37 and 38 218493019742 4 probable transmembrane helices predicted for SBG3581 by TMHMM2.0 at aa 20-37, 41-63, 75-97 and 101-123 218493019744 ferredoxin-NADP reductase; Provisional; Region: PRK10926 218493019745 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 218493019746 FAD binding pocket [chemical binding]; other site 218493019747 FAD binding motif [chemical binding]; other site 218493019748 phosphate binding motif [ion binding]; other site 218493019749 beta-alpha-beta structure motif; other site 218493019750 NAD binding pocket [chemical binding]; other site 218493019754 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 218493019755 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 218493019756 putative active site [active] 218493019758 carries a frameshift mutation following codon 323 218493019761 glycerol kinase; Provisional; Region: glpK; PRK00047 218493019762 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 218493019763 N- and C-terminal domain interface [polypeptide binding]; other site 218493019764 active site 218493019765 MgATP binding site [chemical binding]; other site 218493019766 catalytic site [active] 218493019767 metal binding site [ion binding]; metal-binding site 218493019768 glycerol binding site [chemical binding]; other site 218493019769 homotetramer interface [polypeptide binding]; other site 218493019770 homodimer interface [polypeptide binding]; other site 218493019771 FBP binding site [chemical binding]; other site 218493019772 protein IIAGlc interface [polypeptide binding]; other site 218493019777 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 218493019778 amphipathic channel; other site 218493019779 Asn-Pro-Ala signature motifs; other site 218493019781 6 probable transmembrane helices predicted for SBG3587 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 145-167,180-202 and 232-251 218493019785 septal ring assembly protein ZapB; Provisional; Region: PRK15422 218493019787 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 218493019789 signal peptide predicted for SBG3591 by SignalP 2.0 HMM (Signal peptide probabilty 0.646) with cleavage site probability 0.637 between residues 35 and 36 218493019790 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 218493019791 UbiA prenyltransferase family; Region: UbiA; pfam01040 218493019792 9 probable transmembrane helices predicted for SBG3591 by TMHMM2.0 at aa 21-40, 44-63, 98-120, 124-143,150-172, 177-199, 228-247, 251-270 and 290-307 218493019795 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 218493019796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493019797 Walker A motif; other site 218493019798 ATP binding site [chemical binding]; other site 218493019799 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 218493019800 Walker B motif; other site 218493019801 arginine finger; other site 218493019802 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 218493019806 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 218493019807 active site 218493019808 HslU subunit interaction site [polypeptide binding]; other site 218493019810 essential cell division protein FtsN; Provisional; Region: PRK10927 218493019811 signal peptide predicted for SBG3594 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.383 between residues 45 and 46 218493019812 cell division protein FtsN; Provisional; Region: PRK12757 218493019814 1 probable transmembrane helix predicted for SBG3594 by TMHMM2.0 at aa 35-57 218493019815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493019816 DNA binding site [nucleotide binding] 218493019817 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 218493019818 domain linker motif; other site 218493019819 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 218493019820 dimerization interface [polypeptide binding]; other site 218493019821 ligand binding site [chemical binding]; other site 218493019825 primosome assembly protein PriA; Validated; Region: PRK05580 218493019826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218493019827 ATP binding site [chemical binding]; other site 218493019828 putative Mg++ binding site [ion binding]; other site 218493019829 helicase superfamily c-terminal domain; Region: HELICc; smart00490 218493019830 ATP-binding site [chemical binding]; other site 218493019834 signal peptide predicted for SBG3597 by SignalP 2.0 HMM (Signal peptide probabilty 0.905) with cleavage site probability 0.699 between residues 22 and 23 218493019835 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 218493019837 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 218493019838 dimerization interface [polypeptide binding]; other site 218493019839 DNA binding site [nucleotide binding] 218493019840 corepressor binding sites; other site 218493019842 cystathionine gamma-synthase; Provisional; Region: PRK08045 218493019843 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218493019844 homodimer interface [polypeptide binding]; other site 218493019845 substrate-cofactor binding pocket; other site 218493019846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493019847 catalytic residue [active] 218493019850 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 218493019851 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 218493019852 putative catalytic residues [active] 218493019853 putative nucleotide binding site [chemical binding]; other site 218493019854 putative aspartate binding site [chemical binding]; other site 218493019855 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 218493019856 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 218493019857 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218493019863 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 218493019864 9 probable transmembrane helices predicted for SBG3601 by TMHMM2.0 at aa 19-41, 61-83, 90-107, 122-144,151-173, 178-197, 218-240, 255-277 and 298-317 218493019867 signal peptide predicted for SBG3603 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.522 between residues 20 and 21 218493019868 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 218493019869 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 218493019870 active site 218493019871 metal binding site [ion binding]; metal-binding site 218493019872 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218493019876 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 218493019877 FAD binding site [chemical binding]; other site 218493019879 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 218493019880 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 218493019881 heme binding site [chemical binding]; other site 218493019882 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 218493019888 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 218493019889 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 218493019890 dimer interface [polypeptide binding]; other site 218493019891 active site 218493019892 metal binding site [ion binding]; metal-binding site 218493019897 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 218493019898 active site 218493019899 intersubunit interactions; other site 218493019900 catalytic residue [active] 218493019904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218493019905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493019909 hypothetical protein; Provisional; Region: PRK10649 218493019910 signal peptide predicted for SBG3609 by SignalP 2.0 HMM (Signal peptide probabilty 0.618) with cleavage site probability 0.550 between residues 33 and 34 218493019911 Sulfatase; Region: Sulfatase; pfam00884 218493019913 5 probable transmembrane helices predicted for SBG3609 by TMHMM2.0 at aa 17-39, 49-63, 70-92, 118-140 and 153-170 218493019914 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 218493019915 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 218493019920 acetylornithine deacetylase; Provisional; Region: PRK05111 218493019921 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 218493019922 metal binding site [ion binding]; metal-binding site 218493019923 putative dimer interface [polypeptide binding]; other site 218493019928 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 218493019929 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218493019933 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 218493019934 nucleotide binding site [chemical binding]; other site 218493019935 N-acetyl-L-glutamate binding site [chemical binding]; other site 218493019937 argininosuccinate lyase; Provisional; Region: PRK04833 218493019938 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 218493019939 active sites [active] 218493019940 tetramer interface [polypeptide binding]; other site 218493019943 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 218493019944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493019945 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 218493019946 dimerization interface [polypeptide binding]; other site 218493019950 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 218493019951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218493019952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218493019957 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 218493019958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493019960 hypothetical protein; Provisional; Region: PRK11056 218493019961 signal peptide predicted for SBG3618 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.981 between residues 26 and 27 218493019963 3 probable transmembrane helices predicted for SBG3618 by TMHMM2.0 at aa 25-47, 60-82 and 86-108 218493019965 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 218493019966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493019967 S-adenosylmethionine binding site [chemical binding]; other site 218493019971 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 218493019972 signal peptide predicted for SBG3620 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493019973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493019974 N-terminal plug; other site 218493019975 ligand-binding site [chemical binding]; other site 218493019980 glutamate racemase; Provisional; Region: PRK00865 218493019984 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 218493019985 FAD binding domain; Region: FAD_binding_4; pfam01565 218493019986 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 218493019989 Biotin operon repressor [Transcription]; Region: BirA; COG1654 218493019990 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 218493019991 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 218493019992 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 218493019996 pantothenate kinase; Provisional; Region: PRK05439 218493019997 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 218493019998 ATP-binding site [chemical binding]; other site 218493019999 CoA-binding site [chemical binding]; other site 218493020000 Mg2+-binding site [ion binding]; other site 218493020003 elongation factor Tu; Reviewed; Region: PRK00049 218493020004 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 218493020005 G1 box; other site 218493020006 GEF interaction site [polypeptide binding]; other site 218493020007 GTP/Mg2+ binding site [chemical binding]; other site 218493020008 Switch I region; other site 218493020009 G2 box; other site 218493020010 G3 box; other site 218493020011 Switch II region; other site 218493020012 G4 box; other site 218493020013 G5 box; other site 218493020014 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218493020015 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218493020016 Antibiotic Binding Site [chemical binding]; other site 218493020022 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 218493020023 3 probable transmembrane helices predicted for SBG3626 by TMHMM2.0 at aa 19-36, 40-62 and 94-116 218493020026 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 218493020027 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 218493020028 putative homodimer interface [polypeptide binding]; other site 218493020029 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 218493020030 heterodimer interface [polypeptide binding]; other site 218493020031 homodimer interface [polypeptide binding]; other site 218493020035 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 218493020036 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 218493020037 23S rRNA interface [nucleotide binding]; other site 218493020038 L7/L12 interface [polypeptide binding]; other site 218493020039 putative thiostrepton binding site; other site 218493020040 L25 interface [polypeptide binding]; other site 218493020044 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 218493020045 mRNA/rRNA interface [nucleotide binding]; other site 218493020048 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 218493020049 23S rRNA interface [nucleotide binding]; other site 218493020050 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 218493020053 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 218493020054 core dimer interface [polypeptide binding]; other site 218493020055 peripheral dimer interface [polypeptide binding]; other site 218493020056 L10 interface [polypeptide binding]; other site 218493020057 L11 interface [polypeptide binding]; other site 218493020058 putative EF-Tu interaction site [polypeptide binding]; other site 218493020059 putative EF-G interaction site [polypeptide binding]; other site 218493020062 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 218493020063 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 218493020064 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 218493020065 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218493020066 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 218493020067 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218493020068 RPB3 interaction site [polypeptide binding]; other site 218493020069 RPB1 interaction site [polypeptide binding]; other site 218493020070 RPB11 interaction site [polypeptide binding]; other site 218493020071 RPB10 interaction site [polypeptide binding]; other site 218493020078 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 218493020079 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 218493020080 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 218493020081 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 218493020082 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 218493020083 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 218493020084 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218493020085 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 218493020086 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218493020087 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 218493020088 DNA binding site [nucleotide binding] 218493020089 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 218493020095 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 218493020096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493020097 FeS/SAM binding site; other site 218493020098 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 218493020102 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 218493020103 ThiS interaction site; other site 218493020104 putative active site [active] 218493020105 tetramer interface [polypeptide binding]; other site 218493020107 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 218493020108 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 218493020109 ATP binding site [chemical binding]; other site 218493020110 substrate interface [chemical binding]; other site 218493020113 1 probable transmembrane helix predicted for SBG3636 by TMHMM2.0 at aa 31-53 218493020114 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 218493020115 thiamine phosphate binding site [chemical binding]; other site 218493020116 active site 218493020117 pyrophosphate binding site [ion binding]; other site 218493020119 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 218493020120 ThiC-associated domain; Region: ThiC-associated; pfam13667 218493020121 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 218493020124 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 218493020126 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 218493020127 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 218493020128 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 218493020129 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 218493020130 putative NADH binding site [chemical binding]; other site 218493020131 putative active site [active] 218493020132 nudix motif; other site 218493020133 putative metal binding site [ion binding]; other site 218493020138 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 218493020139 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 218493020140 substrate binding site [chemical binding]; other site 218493020141 active site 218493020145 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 218493020146 Active_site [active] 218493020148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 218493020150 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218493020151 IHF dimer interface [polypeptide binding]; other site 218493020152 IHF - DNA interface [nucleotide binding]; other site 218493020155 signal peptide predicted for SBG3645 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.711 between residues 46 and 47 218493020156 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 218493020159 signal peptide predicted for SBG3646 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.943 between residues 26 and 27 218493020160 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218493020161 dimer interface [polypeptide binding]; other site 218493020162 1 probable transmembrane helix predicted for SBG3646 by TMHMM2.0 at aa 7-29 218493020163 sensor protein ZraS; Provisional; Region: PRK10364 218493020164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493020165 dimer interface [polypeptide binding]; other site 218493020166 phosphorylation site [posttranslational modification] 218493020167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493020168 ATP binding site [chemical binding]; other site 218493020169 Mg2+ binding site [ion binding]; other site 218493020170 G-X-G motif; other site 218493020171 2 probable transmembrane helices predicted for SBG3647 by TMHMM2.0 at aa 10-32 and 204-223 218493020174 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 218493020175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493020176 active site 218493020177 phosphorylation site [posttranslational modification] 218493020178 intermolecular recognition site; other site 218493020179 dimerization interface [polypeptide binding]; other site 218493020180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493020181 Walker A motif; other site 218493020182 ATP binding site [chemical binding]; other site 218493020183 Walker B motif; other site 218493020184 arginine finger; other site 218493020185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218493020192 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 218493020193 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 218493020194 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 218493020195 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 218493020200 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 218493020201 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 218493020202 purine monophosphate binding site [chemical binding]; other site 218493020203 dimer interface [polypeptide binding]; other site 218493020204 putative catalytic residues [active] 218493020205 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 218493020206 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218493020209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 218493020210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493020211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 218493020212 Coenzyme A binding pocket [chemical binding]; other site 218493020214 homoserine O-succinyltransferase; Provisional; Region: PRK05368 218493020215 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 218493020216 proposed active site lysine [active] 218493020217 conserved cys residue [active] 218493020219 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 218493020220 malate synthase A; Region: malate_syn_A; TIGR01344 218493020221 active site 218493020224 isocitrate lyase; Provisional; Region: PRK15063 218493020225 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 218493020226 tetramer interface [polypeptide binding]; other site 218493020227 active site 218493020228 Mg2+/Mn2+ binding site [ion binding]; other site 218493020232 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 218493020233 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 218493020236 transcriptional repressor IclR; Provisional; Region: PRK11569 218493020237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 218493020238 Bacterial transcriptional regulator; Region: IclR; pfam01614 218493020242 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 218493020243 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 218493020244 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 218493020245 substrate binding pocket [chemical binding]; other site 218493020246 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 218493020247 B12 binding site [chemical binding]; other site 218493020248 cobalt ligand [ion binding]; other site 218493020249 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 218493020256 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 218493020257 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 218493020258 8 probable transmembrane helices predicted for SBG3658 by TMHMM2.0 at aa 4-26, 67-89, 99-121, 133-155,175-197, 202-224, 239-261 and 274-296 218493020260 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 218493020261 active site pocket [active] 218493020262 oxyanion hole [active] 218493020263 catalytic triad [active] 218493020264 active site nucleophile [active] 218493020266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218493020267 DNA-binding site [nucleotide binding]; DNA binding site 218493020268 RNA-binding motif; other site 218493020270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 218493020271 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 218493020272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218493020273 RNA binding surface [nucleotide binding]; other site 218493020274 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 218493020275 probable active site [active] 218493020279 hypothetical protein; Provisional; Region: PRK10515 218493020280 signal peptide predicted for SBG3664 by SignalP 2.0 HMM (Signal peptide probabilty 0.606) with cleavage site probability 0.482 between residues 28 and 29 218493020281 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 218493020282 Sodium Bile acid symporter family; Region: SBF; pfam01758 218493020283 9 probable transmembrane helices predicted for SBG3664 by TMHMM2.0 at aa 7-24, 29-51, 64-86, 92-114,119-141, 156-178, 185-207, 217-239 and 260-282 218493020285 aspartate kinase III; Validated; Region: PRK09084 218493020286 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 218493020287 nucleotide binding site [chemical binding]; other site 218493020288 substrate binding site [chemical binding]; other site 218493020289 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 218493020290 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 218493020291 dimer interface [polypeptide binding]; other site 218493020295 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 218493020296 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 218493020297 active site 218493020298 dimer interface [polypeptide binding]; other site 218493020299 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 218493020300 dimer interface [polypeptide binding]; other site 218493020301 active site 218493020305 signal peptide predicted for SBG3667 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.834 between residues 22 and 23 218493020306 1 probable transmembrane helix predicted for SBG3667 by TMHMM2.0 at aa 5-27 218493020307 signal peptide predicted for SBG3668 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.711 between residues 20 and 21 218493020308 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 218493020310 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 218493020312 signal peptide predicted for SBG3669 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21 218493020313 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 218493020316 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 218493020318 4 probable transmembrane helices predicted for SBG3670 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130 218493020319 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 218493020320 signal peptide predicted for SBG3671 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.478 between residues 25 and 26 218493020321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493020322 putative substrate translocation pore; other site 218493020324 12 probable transmembrane helices predicted for SBG3671 by TMHMM2.0 at aa 13-35, 55-77, 90-109,129-151, 164-186, 201-220, 271-293, 313-333, 346-368,373-395, 408-427 and 442-464 218493020328 signal peptide predicted for SBG3672 by SignalP 2.0 HMM (Signal peptide probabilty 0.908) with cleavage site probability 0.439 between residues 33 and 34 218493020329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218493020330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493020331 dimer interface [polypeptide binding]; other site 218493020332 conserved gate region; other site 218493020333 putative PBP binding loops; other site 218493020334 ABC-ATPase subunit interface; other site 218493020336 6 probable transmembrane helices predicted for SBG3672 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175,205-227 and 258-280 218493020338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218493020339 dimer interface [polypeptide binding]; other site 218493020340 conserved gate region; other site 218493020341 putative PBP binding loops; other site 218493020342 ABC-ATPase subunit interface; other site 218493020344 8 probable transmembrane helices predicted for SBG3673 by TMHMM2.0 at aa 17-36, 40-57, 70-92, 284-306,319-341, 370-392, 413-435 and 484-506 218493020347 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 218493020348 signal peptide predicted for SBG3674 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 26 and 27 218493020349 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 218493020350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218493020353 1 probable transmembrane helix predicted for SBG3674 by TMHMM2.0 at aa 7-26 218493020354 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 218493020355 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218493020356 Walker A/P-loop; other site 218493020357 ATP binding site [chemical binding]; other site 218493020358 Q-loop/lid; other site 218493020359 ABC transporter signature motif; other site 218493020360 Walker B; other site 218493020361 D-loop; other site 218493020362 H-loop/switch region; other site 218493020363 TOBE domain; Region: TOBE_2; pfam08402 218493020368 signal peptide predicted for SBG3676 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 25 and 26 218493020369 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 218493020370 trimer interface; other site 218493020371 sugar binding site [chemical binding]; other site 218493020373 signal peptide predicted for SBG3677 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.955 between residues 26 and 27 218493020374 maltose regulon periplasmic protein; Provisional; Region: PRK10564 218493020376 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 218493020378 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 218493020379 UbiA prenyltransferase family; Region: UbiA; pfam01040 218493020380 7 probable transmembrane helices predicted for SBG3679 by TMHMM2.0 at aa 23-40, 45-67, 102-124, 139-161,166-183, 213-235 and 269-288 218493020383 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 218493020384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 218493020385 putative acyl-acceptor binding pocket; other site 218493020387 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 218493020390 2 probable transmembrane helices predicted for SBG3681 by TMHMM2.0 at aa 57-79 and 99-121 218493020392 LexA repressor; Validated; Region: PRK00215 218493020393 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 218493020394 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 218493020395 Catalytic site [active] 218493020398 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 218493020399 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 218493020400 12 probable transmembrane helices predicted for SBG3683 by TMHMM2.0 at aa 11-33, 43-65, 89-111,131-153, 160-182, 187-209, 241-263, 267-289, 321-343,353-375, 388-405 and 409-428 218493020404 hypothetical protein; Provisional; Region: PRK10428 218493020406 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 218493020407 metal binding site 2 [ion binding]; metal-binding site 218493020408 putative DNA binding helix; other site 218493020409 metal binding site 1 [ion binding]; metal-binding site 218493020410 dimer interface [polypeptide binding]; other site 218493020411 structural Zn2+ binding site [ion binding]; other site 218493020413 signal peptide predicted for SBG3686 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.745 between residues 24 and 25 218493020414 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 218493020415 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 218493020416 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218493020417 FMN binding site [chemical binding]; other site 218493020418 active site 218493020419 catalytic residues [active] 218493020420 substrate binding site [chemical binding]; other site 218493020423 phage shock protein G; Reviewed; Region: pspG; PRK09459 218493020424 signal peptide predicted for SBG3689 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.883 between residues 29 and 30 218493020425 2 probable transmembrane helices predicted for SBG3689 by TMHMM2.0 at aa 7-29 and 39-61 218493020426 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 218493020427 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 218493020428 NADP binding site [chemical binding]; other site 218493020429 dimer interface [polypeptide binding]; other site 218493020434 replicative DNA helicase; Provisional; Region: PRK08006 218493020435 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218493020436 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218493020437 Walker A motif; other site 218493020438 ATP binding site [chemical binding]; other site 218493020439 Walker B motif; other site 218493020440 DNA binding loops [nucleotide binding] 218493020444 alanine racemase; Reviewed; Region: alr; PRK00053 218493020445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 218493020446 active site 218493020447 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218493020448 substrate binding site [chemical binding]; other site 218493020449 catalytic residues [active] 218493020450 dimer interface [polypeptide binding]; other site 218493020454 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 218493020455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218493020456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493020457 homodimer interface [polypeptide binding]; other site 218493020458 catalytic residue [active] 218493020461 signal peptide predicted for SBG3694 by SignalP 2.0 HMM (Signal peptide probabilty 0.831) with cleavage site probability 0.702 between residues 24 and 25 218493020462 signal peptide predicted for SBG3695 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.681 between residues 23 and 24 218493020463 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 218493020464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493020465 active site 218493020466 motif I; other site 218493020467 motif II; other site 218493020469 Uncharacterized conserved protein [Function unknown]; Region: COG0432 218493020471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 218493020473 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 218493020474 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 218493020475 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 218493020476 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 218493020482 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 218493020483 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218493020484 dimer interface [polypeptide binding]; other site 218493020485 ssDNA binding site [nucleotide binding]; other site 218493020486 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218493020490 Salmonella Pathogenicity Island 4 (low G+C region) 218493020491 hypothetical protein; Validated; Region: PRK09039 218493020492 1 probable transmembrane helix predicted for SBG3701 by TMHMM2.0 at aa 15-37 218493020493 3 probable transmembrane helices predicted for SBG3702 by TMHMM2.0 at aa 4-26, 90-112 and 149-171 218493020494 signal peptide predicted for SBG3703 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 19 and 20 218493020495 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 218493020498 signal peptide predicted for SBG3704 by SignalP 2.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.659 between residues 35 and 36 218493020499 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218493020500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218493020501 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493020502 1 probable transmembrane helix predicted for SBG3704 by TMHMM2.0 at aa 12-34 218493020503 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020504 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020505 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020506 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020507 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020508 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020509 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020510 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020511 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020512 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020513 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020514 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020515 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020516 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020517 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020518 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020519 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020520 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020521 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020522 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020523 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020524 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020525 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020526 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 218493020527 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020528 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020529 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020530 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020531 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020532 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020533 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020534 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 218493020535 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020536 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020537 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020538 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020561 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 218493020562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493020563 Walker A/P-loop; other site 218493020564 ATP binding site [chemical binding]; other site 218493020565 Q-loop/lid; other site 218493020566 ABC transporter signature motif; other site 218493020567 Walker B; other site 218493020568 D-loop; other site 218493020569 H-loop/switch region; other site 218493020570 4 probable transmembrane helices predicted for SBG3706 by TMHMM2.0 at aa 157-179, 186-208, 274-308 and 376-398 218493020574 2 probable transmembrane helices predicted for SBG3707 by TMHMM2.0 at aa 10-29 and 36-58 218493020576 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 218493020577 signal peptide predicted for SBG3708 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.459 between residues 26 and 27 218493020578 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218493020579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218493020580 2 probable transmembrane helices predicted for SBG3708 by TMHMM2.0 at aa 10-32 and 240-262 218493020582 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 218493020583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493020587 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 218493020588 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 218493020589 DNA binding residues [nucleotide binding] 218493020590 dimer interface [polypeptide binding]; other site 218493020591 [2Fe-2S] cluster binding site [ion binding]; other site 218493020595 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218493020596 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 218493020597 putative C-terminal domain interface [polypeptide binding]; other site 218493020598 putative GSH binding site (G-site) [chemical binding]; other site 218493020599 putative dimer interface [polypeptide binding]; other site 218493020600 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 218493020601 putative N-terminal domain interface [polypeptide binding]; other site 218493020602 putative dimer interface [polypeptide binding]; other site 218493020603 putative substrate binding pocket (H-site) [chemical binding]; other site 218493020606 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 218493020608 12 probable transmembrane helices predicted for SBG3712 by TMHMM2.0 at aa 29-51, 56-78, 85-107,112-134, 146-165, 175-197, 202-224, 244-266, 329-351,356-378, 391-413 and 428-447 218493020611 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 218493020612 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 218493020613 9 probable transmembrane helices predicted for SBG3713 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 181-203,233-255, 276-298, 313-335, 361-383 and 398-420 218493020615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218493020616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493020617 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 218493020618 putative dimerization interface [polypeptide binding]; other site 218493020622 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 218493020623 signal peptide predicted for SBG3715 by SignalP 2.0 HMM (Signal peptide probabilty 0.651) with cleavage site probability 0.367 between residues 20 and 21 218493020624 6 probable transmembrane helices predicted for SBG3715 by TMHMM2.0 at aa 4-21, 33-54, 64-86, 93-115,149-171 and 203-225 218493020626 signal peptide predicted for SBG3716 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 18 and 19 218493020627 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218493020628 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 218493020629 Na binding site [ion binding]; other site 218493020630 13 probable transmembrane helices predicted for SBG3716 by TMHMM2.0 at aa 33-55, 76-98, 103-125,146-168, 183-205, 212-234, 261-283, 303-325, 362-384,404-423, 428-450, 462-484 and 494-516 218493020635 Predicted membrane protein [Function unknown]; Region: COG3162 218493020637 2 probable transmembrane helices predicted for SBG3717 by TMHMM2.0 at aa 25-47 and 62-84 218493020638 acetyl-CoA synthetase; Provisional; Region: PRK00174 218493020639 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 218493020640 active site 218493020641 CoA binding site [chemical binding]; other site 218493020642 acyl-activating enzyme (AAE) consensus motif; other site 218493020643 AMP binding site [chemical binding]; other site 218493020644 acetate binding site [chemical binding]; other site 218493020648 The CDS is a gene remnant that has lost extensive portions of the coding sequence by deletion 218493020649 2 probable transmembrane helices predicted for SBG3719 by TMHMM2.0 at aa 12-34 and 94-116 218493020650 The CDS is a gene remnant that has lost extensive portions of the coding sequence by deletion 218493020652 The CDS is a gene remnant that has lost extensive portions of the coding sequence by deletion 218493020653 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 218493020654 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218493020655 8 probable transmembrane helices predicted for SBG3721 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 160-179,206-228, 233-255, 354-376 and 391-409 218493020659 signal peptide predicted for SBG3722 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 17 and 18 218493020660 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 218493020661 Sel1-like repeats; Region: SEL1; smart00671 218493020666 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 218493020667 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 218493020668 [4Fe-4S] binding site [ion binding]; other site 218493020669 molybdopterin cofactor binding site; other site 218493020670 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 218493020671 molybdopterin cofactor binding site; other site 218493020680 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 218493020681 2 probable transmembrane helices predicted for SBG3725 by TMHMM2.0 at aa 4-22 and 279-301 218493020683 insertion wrt S. Typhi CT18 218493020684 signal peptide predicted for SBG3726 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493020685 involved in alkylphosphonate uptake, carries multiple frameshift mutations 218493020686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493020687 Coenzyme A binding pocket [chemical binding]; other site 218493020690 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 218493020691 dimer interface [polypeptide binding]; other site 218493020692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218493020694 hypothetical protein; Provisional; Region: PRK10220 218493020695 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 218493020696 PhnA protein; Region: PhnA; pfam03831 218493020699 proline/glycine betaine transporter; Provisional; Region: PRK10642 218493020700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493020701 putative substrate translocation pore; other site 218493020702 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 218493020704 12 probable transmembrane helices predicted for SBG3731 by TMHMM2.0 at aa 30-52, 67-89, 98-117,121-143, 163-185, 195-217, 260-282, 297-319, 326-346,351-373, 386-408 and 418-437 218493020707 sensor protein BasS/PmrB; Provisional; Region: PRK10755 218493020708 HAMP domain; Region: HAMP; pfam00672 218493020709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493020710 dimer interface [polypeptide binding]; other site 218493020711 phosphorylation site [posttranslational modification] 218493020712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493020713 ATP binding site [chemical binding]; other site 218493020714 Mg2+ binding site [ion binding]; other site 218493020715 G-X-G motif; other site 218493020719 2 probable transmembrane helices predicted for SBG3732 by TMHMM2.0 at aa 15-37 and 69-91 218493020720 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 218493020721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493020722 active site 218493020723 phosphorylation site [posttranslational modification] 218493020724 intermolecular recognition site; other site 218493020725 dimerization interface [polypeptide binding]; other site 218493020726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493020727 DNA binding site [nucleotide binding] 218493020731 putative metal dependent hydrolase; Provisional; Region: PRK11598 218493020732 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 218493020733 Sulfatase; Region: Sulfatase; pfam00884 218493020736 5 probable transmembrane helices predicted for SBG3734 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 119-141 and 154-176 218493020738 arginine:agmatin antiporter; Provisional; Region: PRK10644 218493020739 11 probable transmembrane helices predicted for SBG3735 by TMHMM2.0 at aa 10-32, 39-61, 94-116,123-142, 152-173, 228-250, 274-296, 324-341, 356-378,385-407 and 411-428 218493020742 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 218493020743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493020747 arginine decarboxylase; Provisional; Region: PRK15029 218493020748 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218493020749 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218493020750 homodimer interface [polypeptide binding]; other site 218493020751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218493020752 catalytic residue [active] 218493020753 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218493020758 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 218493020759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493020763 alpha-galactosidase; Provisional; Region: PRK15076 218493020764 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 218493020765 NAD binding site [chemical binding]; other site 218493020766 sugar binding site [chemical binding]; other site 218493020767 divalent metal binding site [ion binding]; other site 218493020768 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 218493020769 dimer interface [polypeptide binding]; other site 218493020772 melibiose:sodium symporter; Provisional; Region: PRK10429 218493020773 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 218493020774 12 probable transmembrane helices predicted for SBG3740 by TMHMM2.0 at aa 9-31, 36-58, 78-100,110-132, 145-167, 177-199, 236-258, 268-290, 297-319,324-346, 374-396 and 411-433 218493020776 fumarate hydratase; Provisional; Region: PRK15389 218493020777 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 218493020778 Fumarase C-terminus; Region: Fumerase_C; pfam05683 218493020783 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 218493020784 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 218493020785 11 probable transmembrane helices predicted for SBG3742 by TMHMM2.0 at aa 2-19, 23-40, 53-75, 95-117,137-159, 174-196, 236-258, 268-287, 300-322, 359-381 and 421-443 218493020788 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 218493020789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493020790 active site 218493020791 phosphorylation site [posttranslational modification] 218493020792 intermolecular recognition site; other site 218493020793 dimerization interface [polypeptide binding]; other site 218493020795 signal peptide predicted for SBG3744 by SignalP 2.0 HMM (Signal peptide probabilty 0.926) with cleavage site probability 0.449 between residues 53 and 54 218493020796 sensory histidine kinase DcuS; Provisional; Region: PRK11086 218493020797 PAS domain; Region: PAS; smart00091 218493020798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493020799 ATP binding site [chemical binding]; other site 218493020800 Mg2+ binding site [ion binding]; other site 218493020801 G-X-G motif; other site 218493020804 2 probable transmembrane helices predicted for SBG3744 by TMHMM2.0 at aa 20-42 and 183-202 218493020805 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 218493020806 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218493020807 Walker A/P-loop; other site 218493020808 ATP binding site [chemical binding]; other site 218493020809 Q-loop/lid; other site 218493020810 ABC transporter signature motif; other site 218493020811 Walker B; other site 218493020812 D-loop; other site 218493020813 H-loop/switch region; other site 218493020817 signal peptide predicted for SBG3746 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.383 between residues 23 and 24 218493020818 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218493020819 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218493020820 ABC-ATPase subunit interface; other site 218493020821 dimer interface [polypeptide binding]; other site 218493020822 putative PBP binding regions; other site 218493020824 9 probable transmembrane helices predicted for SBG3746 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 109-131,143-165, 185-204, 238-260, 275-297 and 304-321 218493020826 signal peptide predicted for SBG3747 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.414 between residues 16 and 17 218493020827 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 218493020828 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218493020829 putative hemin binding site; other site 218493020831 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 218493020832 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 218493020833 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 218493020835 signal peptide predicted for SBG3749 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 28 and 29 218493020836 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 218493020837 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218493020838 N-terminal plug; other site 218493020839 ligand-binding site [chemical binding]; other site 218493020843 signal peptide predicted for SBG3750 by SignalP 2.0 HMM (Signal peptide probabilty 0.897) with cleavage site probability 0.885 between residues 43 and 44 218493020844 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 218493020845 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 218493020846 putative [Fe4-S4] binding site [ion binding]; other site 218493020847 putative molybdopterin cofactor binding site [chemical binding]; other site 218493020848 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 218493020849 putative molybdopterin cofactor binding site; other site 218493020855 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 218493020858 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 218493020860 8 probable transmembrane helices predicted for SBG3751 by TMHMM2.0 at aa 10-32, 39-61, 81-100, 107-129,139-161, 166-188, 203-221 and 228-250 218493020861 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 218493020863 signal peptide predicted for SBG3753 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 23 and 24 218493020864 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 218493020865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 218493020866 SdiA-regulated; Region: SdiA-regulated; cd09971 218493020867 putative active site [active] 218493020868 1 probable transmembrane helix predicted for SBG3754 by TMHMM2.0 at aa 5-27 218493020870 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 218493020871 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 218493020872 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020873 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020874 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020875 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020876 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020877 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020878 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020879 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020880 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020881 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020882 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020883 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020884 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020885 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020886 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020887 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020888 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020889 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218493020890 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020891 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218493020892 1 probable transmembrane helix predicted for SBG3756 by TMHMM2.0 at aa 15-37 218493020893 low G+C region 218493020894 4 probable transmembrane helices predicted for SBG3757 by TMHMM2.0 at aa 5-22, 35-57, 78-100 and 128-150 218493020897 signal peptide predicted for SBG3758 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493020898 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 218493020899 HlyD family secretion protein; Region: HlyD_3; pfam13437 218493020900 signal peptide predicted for SBG3760 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.530 between residues 30 and 31 218493020901 1 probable transmembrane helix predicted for SBG3760 by TMHMM2.0 at aa 10-32 218493020902 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 218493020903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493020904 Q-loop/lid; other site 218493020905 ABC transporter signature motif; other site 218493020906 Walker B; other site 218493020907 D-loop; other site 218493020908 H-loop/switch region; other site 218493020909 5 probable transmembrane helices predicted for SBG3761 by TMHMM2.0 at aa 128-147, 162-184, 225-247,257-279 and 356-378 218493020912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493020913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493020914 DNA binding residues [nucleotide binding] 218493020915 dimerization interface [polypeptide binding]; other site 218493020917 AraC family transcriptional regulator; Provisional; Region: PRK15186 218493020918 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 218493020919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493020922 this CDS appears to carry a frameshift mutation following codon 799 218493020932 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218493020933 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218493020934 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218493020935 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 218493020936 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 218493020940 1 probable transmembrane helix predicted for SBG3771 by TMHMM2.0 at aa 5-27 218493020942 putative transcriptional regulator; Provisional; Region: PRK11640 218493020943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218493020945 signal peptide predicted for SBG3774 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20 218493020946 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 218493020947 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 218493020948 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 218493020949 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 218493020950 DsbD alpha interface [polypeptide binding]; other site 218493020951 catalytic residues [active] 218493020954 8 probable transmembrane helices predicted for SBG3774 by TMHMM2.0 at aa 5-22, 170-192, 212-234, 246-268,297-319, 326-348, 358-380 and 387-409 218493020956 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 218493020958 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 218493020959 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 218493020960 11 probable transmembrane helices predicted for SBG3776 by TMHMM2.0 at aa 15-37, 50-72, 87-109,130-152, 162-184, 226-243, 258-277, 284-306, 326-345,358-380 and 410-432 218493020962 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 218493020963 Aspartase; Region: Aspartase; cd01357 218493020964 active sites [active] 218493020965 tetramer interface [polypeptide binding]; other site 218493020968 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 218493020969 3 probable transmembrane helices predicted for SBG3778 by TMHMM2.0 at aa 20-42, 47-69 and 100-122 218493020971 signal peptide predicted for SBG3779 by SignalP 2.0 HMM (Signal peptide probabilty 0.845) with cleavage site probability 0.823 between residues 28 and 29 218493020972 putative transporter; Provisional; Region: PRK11021 218493020973 10 probable transmembrane helices predicted for SBG3779 by TMHMM2.0 at aa 7-29, 44-66, 87-109,145-164, 183-205, 220-242, 255-277, 314-336, 343-365 and 385-407 218493020978 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 218493020979 oligomerisation interface [polypeptide binding]; other site 218493020980 mobile loop; other site 218493020981 roof hairpin; other site 218493020984 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218493020985 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218493020986 ring oligomerisation interface [polypeptide binding]; other site 218493020987 ATP/Mg binding site [chemical binding]; other site 218493020988 stacking interactions; other site 218493020989 hinge regions; other site 218493020992 signal peptide predicted for SBG3782 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.437 between residues 28 and 29 218493020993 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 218493020995 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 218493020996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493020997 FeS/SAM binding site; other site 218493020999 elongation factor P; Validated; Region: PRK00529 218493021000 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218493021001 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218493021002 RNA binding site [nucleotide binding]; other site 218493021003 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218493021004 RNA binding site [nucleotide binding]; other site 218493021009 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493021010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493021011 DNA binding residues [nucleotide binding] 218493021012 dimerization interface [polypeptide binding]; other site 218493021017 multidrug efflux system protein; Provisional; Region: PRK11431 218493021019 4 probable transmembrane helices predicted for SBG3787 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104 218493021020 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 218493021021 signal peptide predicted for SBG3788 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.823 between residues 18 and 19 218493021022 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 218493021027 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 218493021028 Iron-sulfur protein interface; other site 218493021029 proximal quinone binding site [chemical binding]; other site 218493021030 C-subunit interface; other site 218493021031 distal quinone binding site; other site 218493021033 3 probable transmembrane helices predicted for SBG3789 by TMHMM2.0 at aa 13-42, 57-79 and 99-118 218493021035 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 218493021036 D-subunit interface [polypeptide binding]; other site 218493021037 Iron-sulfur protein interface; other site 218493021038 proximal quinone binding site [chemical binding]; other site 218493021040 3 probable transmembrane helices predicted for SBG3790 by TMHMM2.0 at aa 27-49, 69-91 and 112-130 218493021041 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 218493021042 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 218493021047 signal peptide predicted for SBG3792 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.426 between residues 25 and 26 218493021048 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 218493021049 L-aspartate oxidase; Provisional; Region: PRK06175 218493021050 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218493021054 poxB regulator PoxA; Provisional; Region: PRK09350 218493021055 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218493021056 motif 1; other site 218493021057 dimer interface [polypeptide binding]; other site 218493021058 active site 218493021059 motif 2; other site 218493021060 motif 3; other site 218493021064 inner membrane transporter YjeM; Provisional; Region: PRK15238 218493021065 signal peptide predicted for SBG3794 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.551 between residues 25 and 26 218493021066 12 probable transmembrane helices predicted for SBG3794 by TMHMM2.0 at aa 12-34, 38-57, 95-117,132-154, 161-183, 208-230, 243-265, 310-332, 364-383,393-415, 435-457 and 467-484 218493021068 putative mechanosensitive channel protein; Provisional; Region: PRK10929 218493021069 signal peptide predicted for SBG3795 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 19 and 20 218493021070 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 218493021071 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218493021074 11 probable transmembrane helices predicted for SBG3795 by TMHMM2.0 at aa 475-492, 521-543, 553-575,596-617, 627-648, 669-691, 696-718, 784-806, 826-848,879-898 and 908-930 218493021075 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 218493021077 GTPase RsgA; Reviewed; Region: PRK12288 218493021078 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218493021079 RNA binding site [nucleotide binding]; other site 218493021080 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 218493021081 GTPase/Zn-binding domain interface [polypeptide binding]; other site 218493021082 GTP/Mg2+ binding site [chemical binding]; other site 218493021083 G4 box; other site 218493021084 G5 box; other site 218493021085 G1 box; other site 218493021086 Switch I region; other site 218493021087 G2 box; other site 218493021088 G3 box; other site 218493021089 Switch II region; other site 218493021092 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 218493021093 catalytic site [active] 218493021094 putative active site [active] 218493021095 putative substrate binding site [chemical binding]; other site 218493021096 dimer interface [polypeptide binding]; other site 218493021099 epoxyqueuosine reductase; Region: TIGR00276 218493021100 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 218493021104 putative carbohydrate kinase; Provisional; Region: PRK10565 218493021105 Uncharacterized conserved protein [Function unknown]; Region: COG0062 218493021106 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 218493021107 putative substrate binding site [chemical binding]; other site 218493021108 putative ATP binding site [chemical binding]; other site 218493021114 ADP-binding protein; Provisional; Region: PRK10646 218493021117 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 218493021118 signal peptide predicted for SBG3802 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.923 between residues 22 and 23 218493021119 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218493021120 active site 218493021121 metal binding site [ion binding]; metal-binding site 218493021123 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 218493021124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493021125 ATP binding site [chemical binding]; other site 218493021126 Mg2+ binding site [ion binding]; other site 218493021127 G-X-G motif; other site 218493021128 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 218493021129 ATP binding site [chemical binding]; other site 218493021130 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 218493021135 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 218493021136 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 218493021139 bacterial Hfq-like; Region: Hfq; cd01716 218493021140 hexamer interface [polypeptide binding]; other site 218493021141 Sm1 motif; other site 218493021142 RNA binding site [nucleotide binding]; other site 218493021143 Sm2 motif; other site 218493021145 GTPase HflX; Provisional; Region: PRK11058 218493021146 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 218493021147 HflX GTPase family; Region: HflX; cd01878 218493021148 G1 box; other site 218493021149 GTP/Mg2+ binding site [chemical binding]; other site 218493021150 Switch I region; other site 218493021151 G2 box; other site 218493021152 G3 box; other site 218493021153 Switch II region; other site 218493021154 G4 box; other site 218493021155 G5 box; other site 218493021158 FtsH protease regulator HflK; Provisional; Region: PRK10930 218493021159 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 218493021160 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 218493021161 1 probable transmembrane helix predicted for SBG3807 by TMHMM2.0 at aa 78-100 218493021163 FtsH protease regulator HflC; Provisional; Region: PRK11029 218493021164 signal peptide predicted for SBG3808 by SignalP 2.0 HMM (Signal peptide probabilty 0.922) with cleavage site probability 0.378 between residues 24 and 25 218493021165 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 218493021166 1 probable transmembrane helix predicted for SBG3808 by TMHMM2.0 at aa 5-23 218493021168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 218493021169 signal peptide predicted for SBG3809 by SignalP 2.0 HMM (Signal peptide probabilty 0.831) with cleavage site probability 0.724 between residues 35 and 36 218493021170 2 probable transmembrane helices predicted for SBG3809 by TMHMM2.0 at aa 5-27 and 42-60 218493021171 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 218493021172 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 218493021173 GDP-binding site [chemical binding]; other site 218493021174 ACT binding site; other site 218493021175 IMP binding site; other site 218493021179 Predicted transcriptional regulator [Transcription]; Region: COG1959 218493021180 transcriptional repressor NsrR; Provisional; Region: PRK11014 218493021182 exoribonuclease R; Provisional; Region: PRK11642 218493021183 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 218493021184 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 218493021185 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218493021186 RNB domain; Region: RNB; pfam00773 218493021187 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 218493021188 RNA binding site [nucleotide binding]; other site 218493021196 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 218493021197 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 218493021198 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218493021201 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 218493021202 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 218493021203 signal peptide predicted for SBG3815 by SignalP 2.0 HMM (Signal peptide probabilty 0.922) with cleavage site probability 0.918 between residues 18 and 19 218493021205 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 218493021206 Predicted membrane protein [Function unknown]; Region: COG3766 218493021207 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 218493021208 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 218493021210 4 probable transmembrane helices predicted for SBG3817 by TMHMM2.0 at aa 6-28, 48-70, 75-97 and 109-131 218493021213 Predicted integral membrane protein [Function unknown]; Region: COG5463 218493021216 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 218493021219 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 218493021220 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 218493021221 FAD binding site [chemical binding]; other site 218493021222 substrate binding site [chemical binding]; other site 218493021223 catalytic residues [active] 218493021229 signal peptide predicted for SBG3821 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.978 between residues 38 and 39 218493021230 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493021232 signal peptide predicted for SBG3822 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.497 between residues 29 and 30 218493021233 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 218493021235 1 probable transmembrane helix predicted for SBG3822 by TMHMM2.0 at aa 13-32 218493021237 esterase; Provisional; Region: PRK10566 218493021238 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218493021239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218493021241 transcriptional repressor UlaR; Provisional; Region: PRK13509 218493021242 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218493021243 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218493021247 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 218493021248 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 218493021250 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 218493021251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 218493021253 10 probable transmembrane helices predicted for SBG3826 by TMHMM2.0 at aa 15-34, 41-63, 100-122,143-172, 233-252, 264-286, 306-328, 340-362, 377-399 and 424-446 218493021255 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218493021256 active site 218493021257 P-loop; other site 218493021258 phosphorylation site [posttranslational modification] 218493021260 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493021261 active site 218493021262 phosphorylation site [posttranslational modification] 218493021266 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 218493021267 active site 218493021268 dimer interface [polypeptide binding]; other site 218493021269 magnesium binding site [ion binding]; other site 218493021271 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 218493021272 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 218493021273 AP (apurinic/apyrimidinic) site pocket; other site 218493021274 DNA interaction; other site 218493021275 Metal-binding active site; metal-binding site 218493021277 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 218493021278 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 218493021279 intersubunit interface [polypeptide binding]; other site 218493021280 active site 218493021281 Zn2+ binding site [ion binding]; other site 218493021283 signal peptide predicted for SBG3832 by SignalP 2.0 HMM (Signal peptide probabilty 0.789) with cleavage site probability 0.625 between residues 32 and 33 218493021284 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 218493021285 4 probable transmembrane helices predicted for SBG3832 by TMHMM2.0 at aa 13-35, 75-97, 109-131 and 141-158 218493021287 signal peptide predicted for SBG3833 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 27 and 28 218493021288 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218493021290 1 probable transmembrane helix predicted for SBG3833 by TMHMM2.0 at aa 12-29 218493021291 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 218493021294 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218493021295 dimer interface [polypeptide binding]; other site 218493021296 ssDNA binding site [nucleotide binding]; other site 218493021297 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218493021299 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 218493021302 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 218493021303 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 218493021304 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 218493021308 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218493021309 EamA-like transporter family; Region: EamA; pfam00892 218493021310 EamA-like transporter family; Region: EamA; pfam00892 218493021311 10 probable transmembrane helices predicted for SBG3839 by TMHMM2.0 at aa 13-34, 54-72, 85-107,117-134, 141-163, 173-192, 204-226, 231-253, 258-280 and 284-303 218493021314 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 218493021315 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 218493021318 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 218493021319 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 218493021320 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218493021325 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 218493021327 12 probable transmembrane helices predicted for SBG3842 by TMHMM2.0 at aa 27-44, 49-71, 104-126,136-158, 165-187, 210-232, 252-274, 289-311, 347-369,374-396, 417-435 and 439-461 218493021329 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 218493021330 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 218493021331 Hemerythrin-like domain; Region: Hr-like; cd12108 218493021332 Fe binding site [ion binding]; other site 218493021336 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218493021337 EamA-like transporter family; Region: EamA; pfam00892 218493021338 10 probable transmembrane helices predicted for SBG3844 by TMHMM2.0 at aa 5-25, 35-52, 64-86, 91-113,120-142, 152-174, 195-217, 232-254, 259-281 and 286-308 218493021341 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 218493021342 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 218493021343 NADP binding site [chemical binding]; other site 218493021345 Predicted transcriptional regulators [Transcription]; Region: COG1733 218493021346 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218493021348 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 218493021349 signal peptide predicted for SBG3847 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 19 and 20 218493021350 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 218493021351 active site 218493021352 metal binding site [ion binding]; metal-binding site 218493021353 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218493021358 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 218493021359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218493021360 active site 218493021364 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 218493021365 signal peptide predicted for SBG3849 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.561 between residues 20 and 21 218493021366 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 218493021368 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218493021369 signal peptide predicted for SBG3851 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.878 between residues 26 and 27 218493021370 Domain of unknown function DUF21; Region: DUF21; pfam01595 218493021371 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218493021372 Transporter associated domain; Region: CorC_HlyC; smart01091 218493021376 4 probable transmembrane helices predicted for SBG3851 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 144-162 218493021377 methionine sulfoxide reductase A; Provisional; Region: PRK00058 218493021379 signal peptide predicted for SBG3853 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 21 and 22 218493021380 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 218493021381 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218493021382 Surface antigen; Region: Bac_surface_Ag; pfam01103 218493021386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 218493021387 signal peptide predicted for SBG3854 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.610 between residues 25 and 26 218493021388 Family of unknown function (DUF490); Region: DUF490; pfam04357 218493021389 1 probable transmembrane helix predicted for SBG3854 by TMHMM2.0 at aa 7-29 218493021392 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 218493021393 putative active site pocket [active] 218493021394 dimerization interface [polypeptide binding]; other site 218493021395 putative catalytic residue [active] 218493021397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493021398 D-galactonate transporter; Region: 2A0114; TIGR00893 218493021399 putative substrate translocation pore; other site 218493021400 12 probable transmembrane helices predicted for SBG3856 by TMHMM2.0 at aa 7-26, 41-63, 76-93, 97-116,137-154, 164-186, 215-237, 252-273, 280-302, 307-329,342-364 and 374-393 218493021403 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 218493021404 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 218493021405 active site 218493021407 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 218493021408 dimer interface [polypeptide binding]; other site 218493021409 substrate binding site [chemical binding]; other site 218493021410 metal binding sites [ion binding]; metal-binding site 218493021413 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 218493021414 AMP binding site [chemical binding]; other site 218493021415 metal binding site [ion binding]; metal-binding site 218493021416 active site 218493021419 signal peptide predicted for SBG3860 by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.726 between residues 24 and 25 218493021420 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 218493021421 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218493021422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218493021423 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218493021427 hypothetical protein; Provisional; Region: PRK05255 218493021429 peptidase PmbA; Provisional; Region: PRK11040 218493021431 cytochrome b562; Provisional; Region: PRK15058 218493021432 signal peptide predicted for SBG3863 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493021433 1 probable transmembrane helix predicted for SBG3863 by TMHMM2.0 at aa 5-23 218493021435 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 218493021437 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 218493021438 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 218493021439 signal peptide predicted for SBG3867 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.539 between residues 30 and 31 218493021440 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 218493021441 6 probable transmembrane helices predicted for SBG3867 by TMHMM2.0 at aa 2-24, 55-77, 111-133, 143-165,177-199 and 214-232 218493021442 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 218493021443 6 probable transmembrane helices predicted for SBG3868 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 110-132,160-182 and 187-209 218493021444 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 218493021445 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 218493021446 active site 218493021448 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 218493021450 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 218493021452 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218493021453 HTH domain; Region: HTH_11; pfam08279 218493021454 Mga helix-turn-helix domain; Region: Mga; pfam05043 218493021455 PRD domain; Region: PRD; pfam00874 218493021456 PRD domain; Region: PRD; pfam00874 218493021457 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 218493021458 active site 218493021459 P-loop; other site 218493021460 phosphorylation site [posttranslational modification] 218493021461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218493021462 active site 218493021463 phosphorylation site [posttranslational modification] 218493021471 Appears to lack an appropriate N-terminus compared to the other VagD orthologues and possesses a frameshift mutation following codon 107 218493021473 Appears to lack an appropriate N-terminus compared to the other VagC orthologues 218493021475 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 218493021476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493021477 FeS/SAM binding site; other site 218493021479 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 218493021480 ATP cone domain; Region: ATP-cone; pfam03477 218493021481 Class III ribonucleotide reductase; Region: RNR_III; cd01675 218493021482 effector binding site; other site 218493021483 active site 218493021484 Zn binding site [ion binding]; other site 218493021485 glycine loop; other site 218493021489 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 218493021490 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 218493021491 Ca binding site [ion binding]; other site 218493021492 active site 218493021493 catalytic site [active] 218493021494 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 218493021496 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 218493021497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218493021498 active site turn [active] 218493021499 phosphorylation site [posttranslational modification] 218493021500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218493021501 10 probable transmembrane helices predicted for SBG3877 by TMHMM2.0 at aa 106-128, 156-178, 185-207,227-244, 256-278, 298-320, 341-360, 370-392, 405-427 and 437-459 218493021505 trehalose repressor; Provisional; Region: treR; PRK09492 218493021506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493021507 DNA binding site [nucleotide binding] 218493021508 domain linker motif; other site 218493021509 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 218493021510 dimerization interface [polypeptide binding]; other site 218493021511 ligand binding site [chemical binding]; other site 218493021515 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 218493021516 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 218493021517 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218493021518 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 218493021519 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 218493021520 Soluble P-type ATPase [General function prediction only]; Region: COG4087 218493021521 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 218493021523 7 probable transmembrane helices predicted for SBG3879 by TMHMM2.0 at aa 122-141, 295-314, 324-346,714-736, 773-795, 836-858 and 873-895 218493021527 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 218493021528 homotrimer interaction site [polypeptide binding]; other site 218493021529 putative active site [active] 218493021532 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 218493021533 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 218493021534 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 218493021537 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 218493021538 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218493021539 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218493021543 Arginine repressor [Transcription]; Region: ArgR; COG1438 218493021544 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218493021545 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218493021548 Predicted membrane protein [Function unknown]; Region: COG1288 218493021549 signal peptide predicted for SBG3884 by SignalP 2.0 HMM (Signal peptide probabilty 0.936) with cleavage site probability 0.252 between residues 29 and 30 218493021550 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 218493021552 11 probable transmembrane helices predicted for SBG3884 by TMHMM2.0 at aa 7-29, 76-98, 121-140,162-184, 205-222, 263-285, 290-307, 322-339, 371-393,413-435 and 442-464 218493021553 ornithine carbamoyltransferase; Validated; Region: PRK02102 218493021554 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218493021555 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218493021559 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 218493021560 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 218493021561 putative substrate binding site [chemical binding]; other site 218493021562 nucleotide binding site [chemical binding]; other site 218493021563 nucleotide binding site [chemical binding]; other site 218493021564 homodimer interface [polypeptide binding]; other site 218493021566 arginine deiminase; Provisional; Region: PRK01388 218493021568 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 218493021570 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 218493021571 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218493021572 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218493021576 RNase E inhibitor protein; Provisional; Region: PRK11191 218493021578 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 218493021579 active site 218493021580 dinuclear metal binding site [ion binding]; other site 218493021581 dimerization interface [polypeptide binding]; other site 218493021583 signal peptide predicted for SBG3892 by SignalP 2.0 HMM (Signal peptide probabilty 0.765) with cleavage site probability 0.672 between residues 27 and 28 218493021584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 218493021585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493021586 Coenzyme A binding pocket [chemical binding]; other site 218493021588 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 218493021590 8 probable transmembrane helices predicted for SBG3894 by TMHMM2.0 at aa 24-46, 67-89, 99-121, 142-164,174-196, 229-251, 281-303 and 324-346 218493021591 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 218493021592 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218493021593 HIGH motif; other site 218493021594 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218493021595 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218493021596 active site 218493021597 KMSKS motif; other site 218493021598 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 218493021599 tRNA binding surface [nucleotide binding]; other site 218493021600 anticodon binding site; other site 218493021601 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 218493021605 DNA polymerase III subunit chi; Validated; Region: PRK05728 218493021607 multifunctional aminopeptidase A; Provisional; Region: PRK00913 218493021608 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 218493021609 interface (dimer of trimers) [polypeptide binding]; other site 218493021610 Substrate-binding/catalytic site; other site 218493021611 Zn-binding sites [ion binding]; other site 218493021616 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 218493021617 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218493021619 6 probable transmembrane helices predicted for SBG3898 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289,296-313 and 328-348 218493021620 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 218493021621 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218493021623 6 probable transmembrane helices predicted for SBG3899 by TMHMM2.0 at aa 10-32, 64-83, 103-125, 279-301,305-322 and 329-351 218493021624 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 218493021625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218493021626 DNA binding site [nucleotide binding] 218493021627 domain linker motif; other site 218493021628 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218493021629 putative dimerization interface [polypeptide binding]; other site 218493021630 putative ligand binding site [chemical binding]; other site 218493021634 signal peptide predicted for SBG3901 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.848 between residues 32 and 33 218493021635 gluconate transporter; Region: gntP; TIGR00791 218493021636 fructuronate transporter; Provisional; Region: PRK10034; cl15264 218493021637 12 probable transmembrane helices predicted for SBG3901 by TMHMM2.0 at aa 12-34, 54-76, 97-114,119-141, 171-193, 219-241, 254-276, 291-312, 324-346,350-372, 379-401 and 416-438 218493021639 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 218493021640 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 218493021641 NADP binding site [chemical binding]; other site 218493021642 homodimer interface [polypeptide binding]; other site 218493021643 active site 218493021646 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 218493021647 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 218493021648 putative NAD(P) binding site [chemical binding]; other site 218493021649 catalytic Zn binding site [ion binding]; other site 218493021652 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 218493021653 ATP-binding site [chemical binding]; other site 218493021654 Gluconate-6-phosphate binding site [chemical binding]; other site 218493021657 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 218493021658 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 218493021659 putative NAD(P) binding site [chemical binding]; other site 218493021660 putative substrate binding site [chemical binding]; other site 218493021661 catalytic Zn binding site [ion binding]; other site 218493021662 structural Zn binding site [ion binding]; other site 218493021663 dimer interface [polypeptide binding]; other site 218493021670 signal peptide predicted for SBG3906 by SignalP 2.0 HMM (Signal peptide probabilty 0.791) with cleavage site probability 0.346 between residues 18 and 19 218493021671 HipA-like N-terminal domain; Region: HipA_N; pfam07805 218493021672 HipA-like C-terminal domain; Region: HipA_C; pfam07804 218493021675 IS element 218493021677 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 218493021678 HNH endonuclease; Region: HNH_2; pfam13391 218493021679 Part of AAA domain; Region: AAA_19; pfam13245 218493021680 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 218493021681 AAA domain; Region: AAA_12; pfam13087 218493021682 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 218493021683 putative active site [active] 218493021684 catalytic site [active] 218493021688 the N-terminus of this CDS is similar to many methyltransferases. This CDS also carries two frame shift mutations following codons 288 and 293 218493021691 hypothetical protein; Provisional; Region: PRK13687 218493021692 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 218493021694 Protein of unknown function DUF91; Region: DUF91; cl00709 218493021695 signal peptide predicted for SBG3921 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.771 between residues 24 and 25 218493021696 Uncharacterized conserved protein [Function unknown]; Region: COG3439 218493021697 1 probable transmembrane helix predicted for SBG3921 by TMHMM2.0 at aa 7-24 218493021699 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 218493021702 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 218493021703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218493021704 DNA-binding site [nucleotide binding]; DNA binding site 218493021705 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218493021709 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 218493021710 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218493021711 active site 218493021712 HIGH motif; other site 218493021713 dimer interface [polypeptide binding]; other site 218493021714 KMSKS motif; other site 218493021717 Protein of unknown function (DUF796); Region: DUF796; cl01226 218493021719 signal peptide predicted for SBG3926 by SignalP 2.0 HMM (Signal peptide probabilty 0.829) with cleavage site probability 0.549 between residues 17 and 18 218493021720 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 218493021721 aspartate racemase; Region: asp_race; TIGR00035 218493021725 cell density-dependent motility repressor; Provisional; Region: PRK10082 218493021726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218493021727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218493021728 dimerization interface [polypeptide binding]; other site 218493021732 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 218493021733 isoaspartyl dipeptidase; Provisional; Region: PRK10657 218493021734 dimer interface [polypeptide binding]; other site 218493021735 active site 218493021737 hypothetical protein; Provisional; Region: PRK10519 218493021738 3 probable transmembrane helices predicted for SBG3929 by TMHMM2.0 at aa 20-42, 68-90 and 130-152 218493021740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 218493021741 Nucleoside recognition; Region: Gate; pfam07670 218493021743 4 probable transmembrane helices predicted for SBG3930 by TMHMM2.0 at aa 21-43, 77-99, 112-131 and 175-197 218493021744 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 218493021745 12 probable transmembrane helices predicted for SBG3931 by TMHMM2.0 at aa 13-35, 55-77, 84-103,108-130, 137-159, 169-191, 212-234, 244-266, 271-293,297-319, 331-353 and 358-380 218493021747 signal peptide predicted for SBG3932 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.302 between residues 53 and 54 218493021748 Predicted membrane protein [Function unknown]; Region: COG2733 218493021750 3 probable transmembrane helices predicted for SBG3932 by TMHMM2.0 at aa 13-32, 42-62 and 395-417 218493021751 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 218493021752 signal peptide predicted for SBG3933 by SignalP 2.0 HMM (Signal peptide probabilty 0.872) with cleavage site probability 0.814 between residues 27 and 28 218493021753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218493021754 putative substrate translocation pore; other site 218493021755 12 probable transmembrane helices predicted for SBG3933 by TMHMM2.0 at aa 13-35, 50-72, 84-103,107-129, 141-163, 167-189, 219-241, 256-278, 290-312,316-338, 350-372 and 376-398 218493021760 putative transposase; Provisional; Region: PRK09857 218493021761 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 218493021763 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 218493021764 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 218493021765 NAD(P) binding site [chemical binding]; other site 218493021766 catalytic residues [active] 218493021770 Protein of unknown function DUF91; Region: DUF91; cl00709 218493021771 Uncharacterized conserved protein [Function unknown]; Region: COG3586 218493021772 endoribonuclease SymE; Provisional; Region: PRK13605 218493021774 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218493021775 6 probable transmembrane helices predicted for SBG3939 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 133-150,155-177 and 189-211 218493021777 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218493021778 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218493021779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493021783 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 218493021784 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 218493021785 P-loop, Walker A motif; other site 218493021786 Base recognition motif; other site 218493021787 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 218493021791 Uncharacterized small protein [Function unknown]; Region: COG2879 218493021793 signal peptide predicted for SBG3943 by SignalP 2.0 HMM (Signal peptide probabilty 0.869) with cleavage site probability 0.682 between residues 27 and 28 218493021794 carbon starvation protein A; Provisional; Region: PRK15015 218493021795 Carbon starvation protein CstA; Region: CstA; pfam02554 218493021796 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 218493021797 16 probable transmembrane helices predicted for SBG3943 by TMHMM2.0 at aa 12-29, 34-56, 89-111,121-140, 161-183, 193-215, 220-242, 257-279, 286-305,325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 665-687 218493021802 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 218493021803 signal peptide predicted for SBG3944 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.447 between residues 34 and 35 218493021804 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218493021805 dimer interface [polypeptide binding]; other site 218493021806 ligand binding site [chemical binding]; other site 218493021807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218493021808 dimerization interface [polypeptide binding]; other site 218493021809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218493021810 dimer interface [polypeptide binding]; other site 218493021811 putative CheW interface [polypeptide binding]; other site 218493021812 2 probable transmembrane helices predicted for SBG3944 by TMHMM2.0 at aa 7-29 and 192-214 218493021817 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 218493021818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493021819 Walker A motif; other site 218493021820 ATP binding site [chemical binding]; other site 218493021821 Walker B motif; other site 218493021822 arginine finger; other site 218493021823 Transcriptional antiterminator [Transcription]; Region: COG3933 218493021824 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493021825 active pocket/dimerization site; other site 218493021826 active site 218493021827 phosphorylation site [posttranslational modification] 218493021828 PRD domain; Region: PRD; pfam00874 218493021835 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218493021836 active pocket/dimerization site; other site 218493021837 active site 218493021838 phosphorylation site [posttranslational modification] 218493021840 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218493021841 active site 218493021842 phosphorylation site [posttranslational modification] 218493021844 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 218493021845 signal peptide predicted for SBG3948 by SignalP 2.0 HMM (Signal peptide probabilty 0.932) with cleavage site probability 0.863 between residues 19 and 20 218493021847 7 probable transmembrane helices predicted for SBG3948 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 96-118,138-160, 180-199 and 206-235 218493021848 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 218493021850 6 probable transmembrane helices predicted for SBG3949 by TMHMM2.0 at aa 73-95, 115-137, 150-172,201-223, 235-257 and 262-281 218493021851 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 218493021852 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218493021853 dimer interface [polypeptide binding]; other site 218493021854 active site 218493021855 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218493021856 dimer interface [polypeptide binding]; other site 218493021857 active site 218493021860 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 218493021861 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 218493021862 putative active site [active] 218493021863 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 218493021866 phosphoglycerol transferase I; Provisional; Region: PRK03776 218493021867 signal peptide predicted for SBG3952 by SignalP 2.0 HMM (Signal peptide probabilty 0.709) with cleavage site probability 0.387 between residues 18 and 19 218493021868 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 218493021870 4 probable transmembrane helices predicted for SBG3952 by TMHMM2.0 at aa 4-19, 26-48, 76-98 and 105-127 218493021871 signal peptide predicted for SBG3953 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.601 between residues 24 and 25 218493021872 hypothetical protein; Provisional; Region: PRK11667 218493021873 DNA replication protein DnaC; Validated; Region: PRK07952 218493021874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218493021875 Walker A motif; other site 218493021876 ATP binding site [chemical binding]; other site 218493021877 Walker B motif; other site 218493021878 primosomal protein DnaI; Provisional; Region: PRK02854 218493021880 hypothetical protein; Provisional; Region: PRK09917 218493021881 4 probable transmembrane helices predicted for SBG3958 by TMHMM2.0 at aa 7-29, 53-75, 87-109 and 129-151 218493021882 Uncharacterized conserved protein [Function unknown]; Region: COG2966 218493021883 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 218493021884 5 probable transmembrane helices predicted for SBG3959 by TMHMM2.0 at aa 129-151, 156-175, 182-204,209-231 and 244-266 218493021887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218493021888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493021889 DNA binding residues [nucleotide binding] 218493021890 dimerization interface [polypeptide binding]; other site 218493021892 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 218493021893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218493021894 DNA binding residues [nucleotide binding] 218493021896 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 218493021897 putative deacylase active site [active] 218493021899 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 218493021900 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 218493021901 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 218493021904 signal peptide predicted for SBG3964 by SignalP 2.0 HMM (Signal peptide probabilty 0.906) with cleavage site probability 0.303 between residues 49 and 50 218493021905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218493021906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218493021907 metal binding site [ion binding]; metal-binding site 218493021908 active site 218493021909 I-site; other site 218493021911 5 probable transmembrane helices predicted for SBG3964 by TMHMM2.0 at aa 21-40, 45-62, 69-86, 101-123 and 144-163 218493021912 signal peptide predicted for SBG3966 by SignalP 2.0 HMM (Signal peptide probabilty 0.907) with cleavage site probability 0.390 between residues 42 and 43 218493021913 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 218493021915 3 probable transmembrane helices predicted for SBG3966 by TMHMM2.0 at aa 19-38, 42-61 and 68-86 218493021916 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 218493021917 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 218493021918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218493021919 S-adenosylmethionine binding site [chemical binding]; other site 218493021923 DNA polymerase III subunit psi; Validated; Region: PRK06856 218493021925 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 218493021926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218493021927 Coenzyme A binding pocket [chemical binding]; other site 218493021929 dUMP phosphatase; Provisional; Region: PRK09449 218493021930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493021931 motif II; other site 218493021933 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 218493021934 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 218493021935 G1 box; other site 218493021936 putative GEF interaction site [polypeptide binding]; other site 218493021937 GTP/Mg2+ binding site [chemical binding]; other site 218493021938 Switch I region; other site 218493021939 G2 box; other site 218493021940 G3 box; other site 218493021941 Switch II region; other site 218493021942 G4 box; other site 218493021943 G5 box; other site 218493021944 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 218493021948 signal peptide predicted for SBG3972 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 28 and 29 218493021949 periplasmic protein; Provisional; Region: PRK10568 218493021950 BON domain; Region: BON; pfam04972 218493021953 signal peptide predicted for SBG3973 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.383 between residues 35 and 36 218493021954 2 probable transmembrane helices predicted for SBG3973 by TMHMM2.0 at aa 7-29 and 33-55 218493021956 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 218493021957 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 218493021958 active site 218493021959 nucleophile elbow; other site 218493021961 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218493021962 active site 218493021967 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 218493021968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218493021969 FeS/SAM binding site; other site 218493021977 hypothetical protein; Provisional; Region: PRK10977 218493021978 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 218493021979 intersubunit interface [polypeptide binding]; other site 218493021980 active site 218493021981 catalytic residue [active] 218493021983 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 218493021984 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218493021985 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 218493021986 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 218493021992 phosphopentomutase; Provisional; Region: PRK05362 218493021993 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 218493021996 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 218493021997 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 218493022001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 218493022002 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 218493022003 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 218493022004 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 218493022006 hypothetical protein; Provisional; Region: PRK11246 218493022007 signal peptide predicted for SBG3984 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.514 between residues 30 and 31 218493022008 1 probable transmembrane helix predicted for SBG3984 by TMHMM2.0 at aa 13-32 218493022009 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 218493022010 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218493022011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218493022012 motif II; other site 218493022014 DNA repair protein RadA; Region: sms; TIGR00416 218493022015 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 218493022016 Walker A motif/ATP binding site; other site 218493022017 ATP binding site [chemical binding]; other site 218493022018 Walker B motif; other site 218493022019 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 218493022022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218493022023 non-specific DNA binding site [nucleotide binding]; other site 218493022024 salt bridge; other site 218493022025 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 218493022026 sequence-specific DNA binding site [nucleotide binding]; other site 218493022027 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 218493022028 active site 218493022029 (T/H)XGH motif; other site 218493022030 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 218493022034 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 218493022035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218493022036 Walker A/P-loop; other site 218493022037 ATP binding site [chemical binding]; other site 218493022038 Q-loop/lid; other site 218493022039 ABC transporter signature motif; other site 218493022040 Walker B; other site 218493022041 D-loop; other site 218493022042 H-loop/switch region; other site 218493022043 ABC transporter; Region: ABC_tran_2; pfam12848 218493022044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218493022050 lytic murein transglycosylase; Provisional; Region: PRK11619 218493022051 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218493022052 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218493022053 catalytic residue [active] 218493022057 Trp operon repressor; Provisional; Region: PRK01381 218493022059 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 218493022061 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218493022062 catalytic core [active] 218493022065 1 probable transmembrane helix predicted for SBG3992 by TMHMM2.0 at aa 146-168 218493022067 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 218493022068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218493022069 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 218493022074 hypothetical protein; Provisional; Region: PRK10756 218493022075 signal peptide predicted for SBG3994 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.969 between residues 21 and 22 218493022076 CreA protein; Region: CreA; pfam05981 218493022078 DNA-binding response regulator CreB; Provisional; Region: PRK11083 218493022079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493022080 active site 218493022081 phosphorylation site [posttranslational modification] 218493022082 intermolecular recognition site; other site 218493022083 dimerization interface [polypeptide binding]; other site 218493022084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493022085 DNA binding site [nucleotide binding] 218493022088 sensory histidine kinase CreC; Provisional; Region: PRK11100 218493022089 signal peptide predicted for SBG3996 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.587 between residues 18 and 19 218493022090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218493022091 dimerization interface [polypeptide binding]; other site 218493022092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218493022093 dimer interface [polypeptide binding]; other site 218493022094 phosphorylation site [posttranslational modification] 218493022095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218493022096 ATP binding site [chemical binding]; other site 218493022097 Mg2+ binding site [ion binding]; other site 218493022098 G-X-G motif; other site 218493022099 2 probable transmembrane helices predicted for SBG3996 by TMHMM2.0 at aa 5-27 and 184-206 218493022103 Inner membrane protein CreD; Region: CreD; cl01844 218493022104 signal peptide predicted for SBG3997 by SignalP 2.0 HMM (Signal peptide probabilty 0.947) with cleavage site probability 0.477 between residues 30 and 31 218493022106 1 probable transmembrane helix predicted for SBG3997 by TMHMM2.0 at aa 10-32 218493022107 signal peptide predicted for SBG3998 by SignalP 2.0 HMM (Signal peptide probabilty 0.862) with cleavage site probability 0.563 between residues 20 and 21 218493022108 putative major fimbrial protein SthE; Provisional; Region: PRK15292 218493022109 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 218493022111 sth fimbrial operon 218493022112 putative fimbrial protein SthD; Provisional; Region: PRK15293 218493022113 signal peptide predicted for SBG3999 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.565 between residues 27 and 28 218493022115 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 218493022116 signal peptide predicted for SBG4000 by SignalP 2.0 HMM (Signal peptide probabilty 0.841) with cleavage site probability 0.840 between residues 28 and 29 218493022117 PapC N-terminal domain; Region: PapC_N; pfam13954 218493022118 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218493022119 PapC C-terminal domain; Region: PapC_C; pfam13953 218493022122 signal peptide predicted for SBG4001 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.990 between residues 20 and 21 218493022123 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 218493022124 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218493022125 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218493022129 1 probable transmembrane helix predicted for SBG4001 by TMHMM2.0 at aa 7-29 218493022130 putative fimbrial protein SthA; Provisional; Region: PRK15296 218493022131 signal peptide predicted for SBG4002 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23 218493022133 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 218493022134 Helix-turn-helix domain; Region: HTH_36; pfam13730 218493022135 two-component response regulator; Provisional; Region: PRK11173 218493022136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218493022137 active site 218493022138 phosphorylation site [posttranslational modification] 218493022139 intermolecular recognition site; other site 218493022140 dimerization interface [polypeptide binding]; other site 218493022141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218493022142 DNA binding site [nucleotide binding] 218493022145 putative RNA methyltransferase; Provisional; Region: PRK10433 218493022146 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050